XENOMETRIX INC \DE\
S-8, 1997-12-16
LABORATORY ANALYTICAL INSTRUMENTS
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<PAGE>   1
   As filed with the Securities and Exchange Commission on December 16, 1997
                                                 Registration No. 333-__________
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            --------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933

                            --------------------

                                XENOMETRIX, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)

                                     
        DELAWARE                                      04-3166089
(State of Incorporation)                 (I.R.S. Employer of Identification No.)

                              2425 N. 55TH STREET
                            BOULDER, COLORADO  80301
                                 (303) 447-1773
         -------------------------------------------------------------
         (Address and telephone number of principal executive offices)

                     AMENDED AND RESTATED STOCK OPTION PLAN
                 1993 NON-EMPLOYEE DIRECTORS STOCK OPTION PLAN
                 ---------------------------------------------
                           (Full title of the plans)

                               RONALD L. HENDRICK
                EXECUTIVE VICE PRESIDENT OF OPERATIONS, FINANCE
                AND ADMINISTRATION, AND CHIEF FINANCIAL OFFICER
                                XENOMETRIX, INC.
                              2425 N. 55TH STREET
                           BOULDER, COLORADO   80301
                                 (303) 447-1773
 ------------------------------------------------------------------------------
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                            --------------------

                                   Copies to:
                           JAMES C.T. LINFIELD, ESQ.
                               COOLEY GODWARD LLP
                        2595 CANYON BOULEVARD, SUITE 250
                        BOULDER, COLORADO    80302-6737
                                 (303) 546-4000 

                            --------------------

<PAGE>   2
                        CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
======================================================================================================================
                                                     PROPOSED MAXIMUM         PROPOSED MAXIMUM
  TITLE OF SECURITIES         AMOUNT TO BE          OFFERING PRICE PER       AGGREGATE OFFERING         AMOUNT OF
   TO BE REGISTERED            REGISTERED                SHARE (1)                PRICE (1)          REGISTRATION FEE
- ----------------------------------------------------------------------------------------------------------------------
<S>                           <C>                   <C>                      <C>                     <C>
Stock Options and                820,955                  $4.125                 $2,183,106                $644
Common Stock (par
value $.001)
======================================================================================================================
</TABLE>

(1)      Estimated solely for the purpose of calculating the amount of the
         registration fee, pursuant to Rule 457(h) under the Securities Act of
         1933, as amended (the "Act")   The offering price per share and
         aggregate offering price are based on (a) the weighted average
         exercise price for shares subject to options and stock previously
         granted under the Registrant's Amended and Restated Stock Option Plan,
         as amended and (b) the price per share and aggregate offering price
         based upon the closing price of Registrant's Common Stock on December
         9, 1997 as reported on the Nasdaq Small-Cap Market for options and
         shares to be granted under the Amended and Restated Stock Option Plan
         and 1993 Non-Employee Directors Stock Option Plan, as amended.  The
         following chart illustrates the calculation of the registration fee:

<TABLE>
<CAPTION>
======================================================================================================================
    TYPE OF SHARES           NUMBER OF SHARES        OFFERING PRICE PER       AGGREGATE OFFERING     REGISTRATION FEE
                                                            SHARE                   PRICE
- ----------------------------------------------------------------------------------------------------------------------
<S>                      <C>                        <C>                    <C>                       <C>
Shares issuable          362,542                    $4.125 (a)             $1,495,486                $441
pursuant to options
outstanding under the
Amended and Restated
Stock Option Plan, as
amended
- ----------------------------------------------------------------------------------------------------------------------
Shares issuable upon
exercise of options      258,413                    $1.50 (b)              387,620                   114
available for grant
under the Amended and
Restated Stock Option
Plan, as amended
- ----------------------------------------------------------------------------------------------------------------------
Shares issuable upon
exercise of options      200,000                    $1.50 (b)              300,000                   89
available for grant
under the 1993 Non-
Employee Directors
Stock Option Plan, as
amended
======================================================================================================================
</TABLE>

         (a)     Weighted average exercise price.
         (b)     Nasdaq Small-Cap Market closing price of the Registrant's
                 Common Stock on December 10, 1997.

================================================================================

         Approximate date of commencement of proposed sale to the public:  As
soon as practicable after this Registration Statement becomes effective.





                                       2.
<PAGE>   3



                    INCORPORATION BY REFERENCE OF CONTENTS
              OF REGISTRATION STATEMENT ON FORM S-8 NO. 33-80889

         The contents of Registration Statement on Form S-8 No. 33-80889 filed
with the Securities and Exchange Commission on December 26, 1995 are
incorporated by reference herein.

                                    EXHIBITS

     EXHIBIT
     NUMBER
     -------
     5.1            Opinion of Cooley Godward LLP.

     10.30          Amendment to Registrant's Amended and Restated  Stock
                    Option Plan.

     10.31          Amendment to Registrant's 1993 Non-Employee Directors Stock
                    Option Plan.

     23.1           Consent of Price Waterhouse LLP.

     23.2           Consent of Cooley Godward LLP is contained in Exhibit 5.1
                    to this Registration Statement.

     24.1           Power of Attorney is contained on the signature pages.





                                       3.
<PAGE>   4



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as
amended, the Registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Boulder, State of
Colorado, on December 16, 1997.

                                       XENOMETRIX, INC.



                                       By:  /s/ Ronald L. Hendrick       
                                            -----------------------------------
                                            Ronald L. Hendrick
                                            Executive Vice President of 
                                            Operations, Finance and 
                                            Administration, and Chief Financial
                                            Officer



                               POWER OF ATTORNEY

         KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Stephen J. Sullivan and Ronald L.
Hendrick, and each or any one of them, his true and lawful attorney-in-fact and
agent, with full power of substitution and resubstitution, for him and in his
name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary to be done in connection therewith, as fully to all intents and
purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents, or any of them, or their or his
substitutes or substitute, may lawfully do or cause to be done by virtue
hereof.





                                       4.
<PAGE>   5



         Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated.

<TABLE>
<CAPTION>
SIGNATURE                                           TITLE                                  DATE
            <S>                                     <C>                                        <C>
             /s/ Stephen J. Sullivan                Chief Executive Officer, President         December 16, 1997
- -----------------------------------------------     and Director (Principal Executive
               Stephen J. Sullivan                  Officer)                         
                                                    


              /s/ Ronald L. Hendrick                Executive Vice President of                December 16, 1997
- -----------------------------------------------     Operations, Finance and            
                Ronald L. Hendrick                  Administration, and Chief Financial
                                                    Officer (Principal Financial and   
                                                    Accounting Officer)                
                                                                                       
                                                    

             /s/ Walter M. Lovenberg                Director                                   December 16, 1997
- -----------------------------------------------
               Walter M. Lovenberg


            /s/ John K.A. Prendergast               Director                                   December 16, 1997
- -----------------------------------------------
              John K.A. Prendergast


             /s/ Randal P. Schumacher               Director                                   December 16, 1997
- -----------------------------------------------
               Randal P. Schumacher


              /s/ Ralph Z. Sorenson                 Director                                   December 16, 1997
- -----------------------------------------------
                Ralph Z. Sorenson

</TABLE>




                                       5.
<PAGE>   6



                                EXHIBIT INDEX


EXHIBIT
NUMBER                     DESCRIPTION                   SEQUENTIAL PAGE NUMBER

5.1         Opinion of Cooley LLP.

10.30       Amendment to Registrant's Amended and 
            Restated Stock Option Plan.

10.31       Amendment to 1993 Registrant's Non-Employee 
            Directors Stock Option Plan.

23.1        Consent of Price Waterhouse LLP.

23.2        Consent of Cooley Godward LLP is contained 
            in  Exhibit 5.1 to this Registration Statement.

24.1        Power of Attorney is contained on the 
            signature pages.






<PAGE>   1
                                                                     EXHIBIT 5.1

                   [COOLEY GODWARD LLP LOGO AND LETTERHEAD]


December 16, 1997

Xenometrix, Inc.
2425 N. 55th Street
Boulder, CO  80301

Ladies and Gentlemen:

You have requested our opinion with respect to certain matters in connection
with the filing by Xenometrix, Inc. (the "Company") of a Registration Statement
on Form S-8 (the "Registration Statement") with the Securities and Exchange
Commission covering the offering of up to 620,955 shares of the Company's
Common Stock, $.001 par value, pursuant to its Amended and Restated Stock
Option Plan, as amended (the "Stock Option Plan"), and 200,000 shares of the
Company's Common Stock, $.001 par value, pursuant to its 1993 Non-Employee
Directors Stock Option Plan (the "Directors' Plan") (collectively, the
"Shares").

In connection with this opinion, we have examined the Registration Statement
and related Prospectus, your Certificate of Incorporation and By-laws, as
amended, and such other documents, records, certificates, memoranda and other
instruments as we deem necessary as a basis for this opinion.  We have assumed
the genuineness and authenticity of all documents submitted to us as originals,
the conformity to originals of all documents submitted to us as copies thereof,
and the due execution and delivery of all documents where due execution and
delivery are a prerequisite to the effectiveness thereof.

On the basis of the foregoing, and in reliance thereon, we are of the opinion
that the Shares, when sold and issued in accordance with the Stock Option Plan
or the Directors' Plan, the Registration Statement and related Prospectus, will
be validly issued, fully paid, and nonassessable (except as to shares issued
pursuant to certain deferred payment arrangements, which will be fully paid and
nonassessable when such deferred payments are made in full).

We consent to the filing of this opinion as an exhibit to the Registration
Statement.

Very truly yours,

COOLEY GODWARD LLP

By:  /s/ James H. Carroll     
     ------------------------------
     James H. Carroll






<PAGE>   1

                                                                   EXHIBIT 10.30


                                XENOMETRIX, INC.

                                  AMENDMENT TO

                     AMENDED AND RESTATED STOCK OPTION PLAN

                           EFFECTIVE NOVEMBER 1, 1992
                    AMENDED AND RESTATED SEPTEMBER 12, 1995


Effective September 9, 1997, the Board of Directors of Xenometrix, Inc. (the
"Company") adopted an amendment to the Company's Amended and Restated Stock
Option Plan (the "Plan") so that section 4 of the Plan was amended and restated
to read as follows:

"4.      SHARES SUBJECT TO THE PLAN.

         (a)     Subject to the provisions of Section 10 relating to
adjustments upon changes in stock, the stock that may be sold pursuant to
Options shall not exceed in the aggregate nine hundred sixty thousand (960,000)
shares of the Company's common stock.  If any Option shall for any reason
expire or otherwise terminate, in whole or in part, without having been
exercised in full, the stock not purchased under such Option shall revert to
and again become available for issuance under the Plan."

                                     1.

<PAGE>   1

                                                                  EXHIBIT 10.31


                                XENOMETRIX, INC.

                                  AMENDMENT TO

                 1993 NON-EMPLOYEE DIRECTORS STOCK OPTION PLAN


Effective September 9, 1997, the Board of Directors of Xenometrix, Inc. (the
"Company") adopted amendments to the Company's 1993 Non-Employee Directors
Stock Option Plan (the "Plan") so that the following sections of the Plan were
amended and restated to read as follows:

"4.      Stock Subject to Plan.

         (a)       The maximum number of shares that may be issued or 
transferred pursuant to Options are 350,000 (or the number and kind of shares
of stock or other securities which are substituted for those Shares or to which
those Shares are adjusted upon a Change in Capitalization), and the Company
shall reserve for the purposes of the Plan, out of its authorized but unissued
Shares or out of Shares held in the Company's treasury, or partly out or each,
such number of Shares as shall be determined by the Board."

"6.      Options.

         "(g)(iii)        If the Optionee ceases to be in service as a director
of the Company for any other reason, the Option (to the extent exercisable at
the time of the Optionee's cessation of service shall be exercisable for a
period of thirty (30) days following such cessation of service, and shall
thereafter terminate; provided, however, that if the Optionee dies within such
thirty-day period, the Option (to the extent exercisable at the time of the
Optionee's cessation of service) shall be exercisable by the Optionee's legal
representative, estate or other person to whom the Optionee's rights are
transferred by will or by laws of descent or distribution for a period of one
(1) year following the Optionee's death (but in no event after the expiration
date of the Option), and shall thereafter terminate."




                                       1.

<PAGE>   1
                                                                    EXHIBIT 23.1

                       CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in the Registration
Statement on Form S-8 (No. 04-3166089) of Xenometrix, Inc. of our report dated
August 28, 1997, appearing on page F-1 of the Xenometrix, Inc. Annual Report on
Form 10-K for the year ended June 30, 1997.




/s/ PRICE WATERHOUSE LLP

PRICE WATERHOUSE LLP


Boulder, Colorado
December 12, 1997

 


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