XENOMETRIX INC \DE\
SC 13D/A, 1998-01-29
LABORATORY ANALYTICAL INSTRUMENTS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                        AMENDED AND RESTATED SCHEDULE 13D
                                (Amendment No. 2)

                    Under the Securities Exchange Act of 1934


                                Xenometrix, Inc.
                         ------------------------------
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                    -------------------------------------------
                         (Title of Class of Securities)

                                    984109108
                         ------------------------------
                                 (CUSIP Number)


Paramount Capital Asset Management, Inc.
c/o Lindsay A. Rosenwald, M.D.
787 Seventh Avenue
New York, NY 10019
(212) 554-4300
                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
New York, NY 10019
(212) 554-4372

    (Name, Address and Telephone Number of Person Authorized to Receive Notices
and Communications)


                                January 12, 1998
             (Date of Event which Requires Filing of this Statement)


                                        1

<PAGE>

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the  subject of this  Statement  because of Rule 13d-
1(b)(3) or (4), check the following:
                                                                       [_]

Check the following box if a fee is being paid with this Statement:
                                                                       [_]



                                        2


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 984109108              13D                   Page 3 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Paramount Capital Asset Management, Inc.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]


- -------------------------------------------------------------------------------
    3      SEC USE ONLY



- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 563,994
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          563,994
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           563,994
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           16.2%
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           CO
- -------------------------------------------------------------------------------


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 984109108              13D                   Page 4 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Aries Domestic Fund, L.P.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]


- -------------------------------------------------------------------------------
    3      SEC USE ONLY



- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware

- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 192,332
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          194,332
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           192,332
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           6.1%
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           PN
- -------------------------------------------------------------------------------


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 984109108              13D                   Page 5 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           The Aries Trust
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]


- -------------------------------------------------------------------------------
    3      SEC USE ONLY


- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           Cayman Islands

- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          None
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 371,662
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   None 
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          371,662
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           371,662
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           11.2%
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           CO
- -------------------------------------------------------------------------------


<PAGE>

- --------------------------                       -------------------------------
CUSIP No. 984109108              13D                   Page 6 of 11 Pages
- --------------------------                       -------------------------------

- -------------------------------------------------------------------------------
    1      NAMES OF REPORTING PERSONS
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Lindsay A. Rosenwald, M.D.
- -------------------------------------------------------------------------------
    2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP    (a)   [_]
                                                               (b)   [_]


- -------------------------------------------------------------------------------
    3      SEC USE ONLY



- -------------------------------------------------------------------------------
    4      SOURCE OF FUNDS*

           OO (see Item 3)
- -------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED 
           PURSUANT TO ITEM 2(d) or 2(e)
                                                                     [_]
- -------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION

           United States

- -------------------------------------------------------------------------------
                                   7      SOLE VOTING POWER

                                          155,607**
                 NUMBER OF         --------------------------------------------
                  SHARES           8      SHARED VOTING POWER    
               BENEFICIALLY
                 OWNED BY                 719,422**
                   EACH            --------------------------------------------
                REPORTING          9      SOLE DISPOSITIVE POWER 
                  PERSON
                   WITH                   155,607**
                                   --------------------------------------------
                                   10     SHARED DISPOSITIVE POWER

                                          719,422**
- -------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           719,422**
- -------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW 11 EXCLUDES CERTAIN SHARES*

                                                                     [_]
- -------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

           20.5%**
- -------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON*

           IN
- -------------------------------------------------------------------------------


- ----------------------------
**   Includes  9,090  shares of Common  Stock of the Issuer  held by June Street
     Company, of which Dr. Rosenwald is the President and 9,090 shares of Common
     Stock of the  Issuer  held by  Huntington  Street  Company,  of  which  Dr.
     Rosenwald is the President.  Includes  25,733  warrants to purchase  common
     stock  held by  Paramount  Capital,  Inc.,  of which Dr.  Rosenwald  is the
     Chairman  and sole  shareholder.  Does not include an  aggregate  of 65,858
     shares  owned by Dr.  Rosenwald's  wife and trusts  for the  benefit of his
     minor children, of which Dr. Rosenwald disclaims beneficial ownership.


<PAGE>

Item 1.           Security and Issuer.

         (a)      Common Stock, $.001 par value ("Shares")

                  Xenometrix, Inc.
                  2425 North 55th Street
                  Boulder, Colorado 97224
                  303-447-1773

Item 2.           Identity and Background.

         Names of Persons Filing:

         (a)      This  statement is filed on behalf of Paramount  Capital Asset
                  Management,  Inc. ("Paramount Capital"),  Aries Domestic Fund,
                  L.P. ("Aries  Domestic"),  The Aries Trust ("Aries Trust") and
                  Dr. Lindsay A. Rosenwald ("Dr.  Rosenwald",  and  collectively
                  with  the  Aries  Trust  and  Aries  Domestic,   the"Reporting
                  Parties").  See  attached  Exhibit  A which is a copy of their
                  agreement in writing to file this  statement on behalf of each
                  of them.

         (b)      The business address of Paramount Capital,  Aries Domestic and
                  Dr.  Rosenwald's is 787 Seventh Avenue,  48th Floor, New York,
                  New York,  10019.  The business address for Aries Trust is c/o
                  MeesPierson (Cayman) Limited,  P.O. Box 2003, British American
                  Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

         (c)      Dr.  Rosenwald is an investment  banker,  venture  capitalist,
                  fund manager and sole shareholder of  Paramount  Capital,/1/ a
                  Subchapter  S  corporation   incorporated   in  the  State  of
                  Delaware.  Paramount  Capital is the General  Partner of Aries
                  Domestic,/2/ a limited partnership
- --------
/1/  Please  see  attached  Exhibit B  indicating  the  executive  officers  and
     directors  of Paramount  Capital and  providing  information  called for by
     Items 2-6 of this statement as to said officers and directors. Exhibit B is
     herein incorporated by reference.

/2/  Please see  attached  Exhibit C  indicating  the  general  partner of Aries
     Domestic and the general  partner's  executive  officers and  directors and
     providing  information called for by Items 2-6 of this statement as to said
     general partners, officers and directors.  Exhibit C is herein incorporated
     by reference.


                                        7

<PAGE>

                    incorporated   in   Delaware.   Paramount   Capital  is  the
                    Investment  Manager  to Aries  Trust,/3/  a  Cayman  Islands
                    Trust.

         (d)        Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries
                    Trust  and their  respective  officers,  directors,  general
                    partners,  investment managers, or trustees have not, during
                    the five years prior to the date hereof, been convicted in a
                    criminal proceeding (excluding traffic violations or similar
                    misdemeanors).

         (e)        Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries
                    Trust  and their  respective  officers,  directors,  general
                    partners,  investment  managers,  or trustees have not been,
                    during the five years prior to the date hereof, parties to a
                    civil  proceeding  of a judicial or  administrative  body of
                    competent jurisdiction, as a result of which such person was
                    or is subject to a judgment, decree or final order enjoining
                    future violations of, or prohibiting or mandating activities
                    subject to, Federal or State  securities laws or finding any
                    violation with respect to such laws.

         (f)        Dr. Rosenwald is a citizen of the United States.

Item 3.             Source and Amount of Funds or Other Consideration.

                    Since the date of the last  filing on October 30,  1997,  on
                    December 15, 1997 and on January 12, 1998 (each a "Draw Down
                    Date"),  Aries  Domestic  used its general funds to extend a
                    line of credit  (the "Line of  Credit") to the Issuer in the
                    aggregate  amount  of  $165,000  ($82,500  on each Draw Down
                    Date) for which Aries Domestic  received warrants (the "Line
                    of Credit  Warrants")to  purchase an aggregate 55,000 shares
                    of common stock,  par value $.001 (the "Common  Stock"),  of
                    the  Issuer  (27,500  shares on each  Draw Down  Date) at an
                    exercise price equal to $2.14816 and on the same dates,  the
                    Aries  Trust  used its  general  funds  to  extend a Line of
                    Credit to the  Issuer in the  aggregate  amount of  $335,000
                    ($167,500  on each Draw Down Date) for which the Aries Trust
                    received  Line of Credit  Warrants to purchase an  aggregate
                    111,666  shares of Common Stock (55,833  shares on each Draw
                    Down Date) at an exercise price equal to $2.14816.

Item 4.             Purpose of Transaction.

                    The Reporting Parties acquired shares of Common Stock of the
                    Issuer as an investment in the Issuer.

                  Although  the  Reporting   Parties  have  not  formulated  any
                  definitive  plans,  they may  from  time to time  acquire,  or
                  dispose of, Common
- --------
/3/  Please see attached  Exhibit D  indicating  the  investment  manager of the
     Aries Trust and the investment  manager's executive officers and direc tors
     and providing  information  called for by Items 2-6 of this statement as to
     said  investment  manager and officers and  directors.  Exhibit D is herein
     incorporated by reference.


                                        8

<PAGE>

                    Stock and/or other securities of the Issuer if and when they
                    deem it  appropriate.  The  Reporting  Parties may formulate
                    other purposes,  plans or proposals  relating to any of such
                    securities of the Issuer to the extent  deemed  advisable in
                    light of market  conditions,  investment  policies and other
                    factors.

                    Except as indicated  in this  Schedule  13D,  the  Reporting
                    Parties  currently have no plans or proposals that relate to
                    or  would  result  in  any  of  the  matters   described  in
                    subparagraphs (a) through (j) of Item 4 of Schedule 13D.

Item 5.  Interest in Securities of the Issuer.

               (a)  As of January  12, 1998 Aries  Domestic,  Aries  Trust,  Dr.
                    Rosenwald   and   Paramount   Capital   beneficially   owned
                    securities of the Issuer as follows:

                                              Amount Owned     Percentage
                                              ------------     ----------
                           Aries Domestic     192,332 Shares         6.1%
                           Aries Trust        371,662 Shares        11.2%
                           Paramount Capital  563,994 Shares        16.2%
                           Dr. Rosenwald      719,422 Shares        20.5%

               (b)  Dr. Rosenwald and Paramount  Capital share the power to vote
                    or  to  direct  the  vote,  to  dispose  or  to  direct  the
                    disposition  of those shares owned by each of Aries Domestic
                    and Aries Trust. Dr. Rosenwald has the sole power to vote or
                    direct,  to  dispose or to direct  the  disposition  102,876
                    shares held by Dr. Rosenwald  personally,  9,090 shares held
                    by June  Street  Company,  of  which  Dr.  Rosenwald  is the
                    President,  and  9,090  shares  held  by  Huntington  Street
                    Corporation,  of which Dr.  Rosenwald is the President.  Dr.
                    Rosenwald will have the sole power to vote, direct the vote,
                    dispose or direct the disposition of 25,733 shares of common
                    stock of the  Issuer  that are  issuable  upon the  exercise
                    warrants  held by  Paramount  Capital,  Inc.,  of which  Dr.
                    Rosenwald is the Chairman and sole shareholder.

               (c)  In addition to those transactions reported in a Schedule 13D
                    filed on October 7, 1997 and a Schedule 13D Amendment, filed
                    on October 30,  1997,  on December  15, 1997 and January 12,
                    1998 Aries  Domestic used its general funds to extend a line
                    of  credit  (the  "Line of  Credit")  to the  Issuer  in the
                    aggregate  amount  of  $165,000  ($82,500  on each Draw Down
                    Date) for which Aries Domestic  received warrants (the "Line
                    of Credit  Warrants")to  purchase an aggregate 55,000 shares
                    of common stock,  par value $.001 (the "Common  Stock"),  of
                    the  Issuer  (27,500  shares on each  Draw Down  Date) at an
                    exercise price equal to $2.14816 and on the same dates,  the
                    Aries  Trust  used its  general  funds  to  extend a Line of
                    Credit to the  Issuer in the  aggregate  amount of  $335,000
                    ($167,500  on each Draw Down Date) for which the Aries Trust
                    received Line of Credit


                                        9

<PAGE>



                    Warrants to purchase an aggregate  111,666  shares of Common
                    Stock (55,833  shares on each Draw Down Date) at an exercise
                    price equal to $2.14816.

                    Other than as set forth  herein the  Reporting  Parties have
                    not engaged in any  transactions  in the Common Stock of the
                    Issuer during the past 60 days.

               (d) & (e)         Not applicable.

Item 6.        Contracts,  Arrangements,  Understandings  or Relationships  with
               respect to Securities of the Issuer

               Paramount  Capital is the  investment  manager of the Aries Trust
               and the General  Partner of Aries Domestic and in such capacities
               has the authority to make certain investment  decisions on behalf
               of such entities,  including decisions relating to the securities
               of the  Issuer.  In  connection  with its  investment  management
               duties,  Paramount  Capital receives certain  management fees and
               performance  allocations from the Aries Trust and Aries Domestic.
               Dr.  Rosenwald is the sole  shareholder of Paramount  Capital and
               serves as a member of the Board of Directors of the Issuer.  John
               K. A.  Prendergast,  Ph.D.,  a  Managing  Director  of  Paramount
               Capital Investments, LLC, an affiliate of Paramount Capital, Inc.
               also serves as a member of the Board of  Directors of the Issuer.
               Except as indicated in this Schedule 13D and  exhibits,  there is
               no contract,  arrangement, under standing or relationship between
               the Reporting  Parties and any other person,  with respect to any
               securities of the Issuer.

Item 7.        Material to be Filed as Exhibits:

Exhibit A -    Copy of an Agreement  between Dr. Rosenwald,  Paramount  Capital,
               Aries Domestic and Aries Trust to file this Statement on Schedule
               13D on behalf of each of them.

Exhibit B -    List of executive officers and directors of Paramount Capital and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit C -    List of executive  officers and  directors of Aries  Domestic and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.

Exhibit D -    List of  executive  officers  and  directors  of Aries  Trust and
               information called for by Items 2-6 of this statement relating to
               said officers and directors.


                                       10

<PAGE>

                                   SIGNATURES


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


                                          PARAMOUNT CAPITAL ASSET MANAGEMENT,
                                          INC.

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


                                          ARIES DOMESTIC FUND, L.P.
                                          By Paramount Capital Asset
                                          Management, Inc.
                                          General Partner

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


                                           THE ARIES TRUST
                                           By Paramount Capital Asset
                                           Management, Inc.
                                           Investment Manager

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


                                       11

<PAGE>

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D



                  The undersigned hereby agrees to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting each of the undersigned's ownership of securities of Xenometrix,  Inc.
and hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.


                                          PARAMOUNT CAPITAL ASSET MANAGEMENT,
                                          INC.

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


                                          ARIES DOMESTIC FUND, L.P.
                                          By Paramount Capital Asset
                                          Management, Inc.
                                          General Partner

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


                                           THE ARIES TRUST
                                           By Paramount Capital Asset
                                           Management, Inc.
                                           Investment Manager

Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


Dated:   January 28, 1998
         New York, NY                     By /s/Lindsay A. Rosenwald, M.D.
                                            --------------------------------
                                            Lindsay A. Rosenwald, M.D.
                                            President


<PAGE>

                                    EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                             PRINCIPAL OCCUPATION
         NAME                                OR EMPLOYMENT
         ----                                -------------

Lindsay A. Rosenwald, M.D.                   Chairman of the Board, President of
                                             Paramount Capital Asset Management,
                                             Inc., Paramount Capital Investments
                                             LLC and Paramount Capital, Inc.

Peter Morgan Kash                            Director of Paramount Capital Asset
                                             Management,  Inc.,  Senior Managing
                                             Director, Paramount Capital, Inc.

Dr. Yuichi Iwaki                             Director  of    Paramount   Capital
                                             Asset  Management, Inc., Professor,
                                             University  of Southern  California
                                             School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


<PAGE>

                                    EXHIBIT C

         The name and principal  occupation or employment of the General Partner
of Aries Domestic, which is located at 787 Seventh Avenue, 48th Floor, New York,
New York, 10019, is as follows:

                                                          PRINCIPAL OCCUPATION
         NAME                                                OR EMPLOYMENT
         ----                                                -------------

Paramount Capital Asset Management, Inc.         General Partner; Investment
Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


<PAGE>

                                    EXHIBIT D

         The name and principal  occupation or employment,  which in the case of
Paramount Capital Asset Management,  Inc. is located at 787 Seventh Avenue, 48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                    PRINCIPAL OCCUPATION
         NAME                                          OR EMPLOYMENT
         ----                                          -------------

Paramount Capital Asset Management, Inc.            Investment Manager

MeesPierson (Cayman) Limited                        Trustee
P.O. Box 2003
British American Centre
Phase 3, Dr. Roy's Drive
George Town, Grand Cayman

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.




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