PATHOGENESIS CORP
4, 1998-08-10
PHARMACEUTICAL PREPARATIONS
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[  ] Check this box if no longer subject of Section 16. Form 4 or Form 5
     obligations may continue. See Instruction 1(b).

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1. Name and Address of Reporting Person*

Wilpon,                            Fred
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   (Last)                           (First)             (Middle)

c/o Sterling PathoGenesis Company
575 Fifth Avenue
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                                    (Street)

New York                           New York              10017
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   (City)                           (State)              (Zip)


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2. Issuer Name and Ticker or Trading Symbol


   PathoGenesis Corporation ("PGNS")
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3. IRS or Social Security Number of Reporting Person (Voluntary)

   
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4. Statement for Month/Year

   July 1998
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5. If Amendment, Date of Original (Month/Year)

   
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6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   [ X ]   Director                             [   ]   10% Owner
   [   ]   Officer (give title below)           [   ]   Other (specify below)



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7. Individual or Joint/Group Filing (Check applicable line)

   [ X ]   Form filed by one Reporting Person
   [   ]   Form filed by more than one Reporting Person


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           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
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<S>                                   <C>            <C>      <C>    <C>         <C>    <C>      <C>            <C>       <C>

Common Stock, par value 
  $.001 per share                                                                                  19,000       D(1)(2)
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                                      7/31/98        P              10,000        A     $28.56    765,750       I         (3)
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                                      7/31/98        P              10,000        A     $28.06
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====================================================================================================================================
</TABLE>
* If the Form is filed by more than one Reporting Person, see Instruction 
  4(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

                                                                          (Over)
                           (Print or Type Responses)             SEC 1474 (7/96)


<PAGE>


FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                          9.        10.    
                                                                                                          Number    Owner- 
                                                                                                          of        ship   
                    2.                                                                                    Deriv-    of     
                    Conver-                    5.                              7.                         ative     Deriv-   11.    
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature 
                    of                         Derivative    6.                of Underlying     8.       ities     Secur-   of     
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity;     In-    
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct 
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-  
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial 
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner- 
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship   
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>


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====================================================================================================================================
</TABLE>
Explanation of Responses:

(1) Include 9,000 shares of common stock held jointly by Reporting
    Person and his spouse.
(2) Includes 10,000 shares of common stock held jointly by the Reporting
    Person and a partner in Sterling PathoGenesis Company ("Sterling"). The
    Reporting Person disclaims beneficial ownership of such shares, except to 
    the extent of his pecuniary interest.
(3) Held by Sterling, of which the Reporting Person is managing partner. The
    Reporting Person disclaims beneficial ownership of such shares, except to 
    the extent of his pecuniary interest. Certain other partners in Sterling 
    hold securities of the Issuer outside of Sterling.

                                          /s/ Fred Wilpon              8/10/98
                                   -------------------------------     -------
                                   **Signature of Reporting Person       Date
                                   
                           

** Intentional misstatements or omissions of facts constitute Federal 
   Criminal Violations.
   See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedures.


                                                                 SEC 1474 (7/96)



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