PATHOGENESIS CORP
S-8, 1999-09-23
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                                     Registration No. 333-______

      As filed with the Securities and Exchange Commission on September 22, 1999
================================================================================

                      SECURITIES AND EXCHANGE COMMISSION

                             Washington, DC 20549

                         ____________________________
                                    FORM S-8

                            REGISTRATION STATEMENT

                                     Under

                          the Securities Act of 1933

                         ____________________________

                           PathoGenesis Corporation
            (Exact Name of Registrant as Specified in Its Charter)


                DELAWARE                              91-1542150
      (State or Other Jurisdiction                 (I.R.S. Employer
   of Incorporation or Organization)              Identification No.)



                            201 Elliott Avenue West
                           Seattle, Washington 98119
                    (Address of Principal Executive Offices)


                            PathoGenesis Corporation
                        1999 Employee Stock Option Plan
                            (Full Title of the Plan)

            Cameron S. Avery                          Copies to:
            General Counsel                          Woon-Wah Siu
        PathoGenesis Corporation                  Bell, Boyd & Lloyd
    5215 Old Orchard Road, Suite 900          Three First National Plaza
         Skokie, Illinois 60077                 Chicago, Illinois 60602
             (847) 583-8050                         (312) 372-1121

           (Name, Address and Telephone Number of Agents for Service)

                        ________________________________

                        CALCULATION OF REGISTRATION FEE


<TABLE>
<CAPTION>
========================================================================================================================
                                                              Proposed                Proposed
                                        Amount                Maximum                 Maximum                Amount of
       Title of Each Class of            to be             Offering Price             Aggregate             Registration
    Securities to be Registered      Registered(1)            Per Share            Offering Price                Fee
- ------------------------------------------------------------------------------------------------------------------------
<S>                                 <C>                    <C>                     <C>                      <C>
Common Stock, par value
 $.001 per share                    483,500 shares           $13.53(2)             $6,543,786(2)             $1,819(2)
- ------------------------------------------------------------------------------------------------------------------------
Common Stock, par value
 $.001 per share                    116,500 shares           $15.56(3)             $1,813,031(3)             $  504(3)
========================================================================================================================
</TABLE>
 (1)  Includes 600,000 Preferred Stock Purchase Rights evidenced by certificates
      of shares of common stock that automatically trade with such common stock.
      Also includes an indeterminate number of additional shares, and the
      associated Preferred Stock Purchase Rights, that may become issuable under
      the antidilution and other adjustment provisions of the PathoGenesis
      Corporation 1999 Employee Stock Option Plan pursuant to Rule 416(a) of the
      Securities Act of 1933, as amended.
 (2)  Based on the weighted average exercise price of currently outstanding
      options under the 1999 Employee Stock Option Plan.
 (3)  In accordance with Rule 457(h), calculated on the basis of the average of
      the high and low sale prices of the Registrant's common stock as quoted in
      the consolidated reporting system of the Nasdaq National Market on
      September 20, 1999, as reported by The Wall Street Journal (Midwest
      Edition).
================================================================================
<PAGE>

                                    PART I

             INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

Item 1.   Plan Information.

          Not required to be included herewith.

Item 2.   Registrant Information and Employee Plan Annual Information.

          Not required to be included herewith.

                                    PART II

              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.   Incorporation of Documents by Reference.

          We, PathoGenesis Corporation, are filing this registration statement
on Form S-8 to register shares of our common stock, par value $.001 per share.

          We incorporate by reference the following documents in this
registration statement:

               (a)  Our annual report on Form 10-K for the fiscal year ended
          December 31, 1998 (File No. 0-27150);

               (b)  Our quarterly reports on Form 10-Q for the quarters ended
          March 31, 1999 and June 30, 1999, (File No. 0-27150);

               (c)  The description of our common stock set forth under the
          caption "Description of Capital Stock -- Common Stock" in our
          prospectus constituting a part of the registration statement on Form
          S-1 (Reg. No. 333-22297), filed on February 25, 1997; and

               (d)  The description of our Preferred Stock Purchase Rights in
          the registration statement on Form 8-A filed on July 10, 1997, for the
          registration of those Rights under Section 12(g) of the Securities
          Exchange Act of 1934, as amended by amendment filed on April 15, 1999
          (File No. 0-27150).

          Incorporation by reference means that we are making the documents
listed above a part of this registration statement by referring to them and
declaring that you should consider them to be part of this registration
statement as if they were fully copied in this registration statement. We also
incorporate by reference all documents we subsequently file under Sections
13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, before we
file a post-effective amendment to indicate that all shares of common stock
offer by this registration statement have been sold or to deregister all the
shares then remaining unsold. For purposes of this registration statement, you
should consider any statement contained in a document incorporated by reference
in this registration statement to be modified or superseded to the extent that a
statement contained in this registration statement or in any other subsequently
filed document which also is incorporated by reference in this registration
statement modifies or replaces such statement. You should not consider any
statement so modified or superseded, except as so modified or superseded, to be
a part of this registration statement.

Item 4.   Description of Securities.

          Not applicable.

                                       1
<PAGE>

Item 5.   Interests of Named Experts and Counsel.

          Not applicable.

Item 6.   Indemnification of Directors and Officers.

          Section 145 of the Delaware General Corporation Law authorizes a
Delaware corporation to indemnify any director or officer against expenses,
judgments, fines and settlements actually and reasonably incurred by such person
in connection with any action, suit or proceeding, if such director or officer
acted in good faith and in a manner such person reasonably believed to be in or
not opposed to the best interests of the corporation and, with respect to any
criminal action or proceeding, had no reasonable cause to believe his or her
conduct was unlawful, except that no indemnification shall be made in connection
with any action by or in the right of the corporation if such person is adjudged
to be liable to the corporation, unless the court determines that despite the
adjudication of liability such person is fairly and reasonably entitled to
indemnity for such expense that the court shall deem proper. Said section
further provides that to the extent that any such person is successful on the
merits or otherwise in defense of any action such director or officer shall be
indemnified against expenses actually and reasonably incurred by him or her. In
addition, a Delaware corporation is authorized to purchase insurance on behalf
of its directors and officers against liabilities whether or not in the
circumstances the corporation would have the power to indemnify against such
liabilities under said section.

          The Company's Amended and Restated Certificate of Incorporation
provides for indemnification of the Company's directors, officers, employees and
agents, to the fullest extent permitted by the Delaware General Corporation Law,
against all expense, liability and loss reasonably incurred or suffered by each
such person in connection with any action, suit, or proceeding to which such
person was or is made a party or is threatened to be a party by reason of the
fact that such person is a director, officer, employee or agent of the Company;
provided, however, except as provided in the Amended and Restated Certificate of
Incorporation with respect to proceedings to enforce rights to indemnification,
the Company shall indemnify any such person in connection with a proceeding
initiated by such person if the proceeding was authorized by the board of
directors of the Company. The Company has obtained directors and officers
insurance covering its directors and executive officers.

          The Company's Amended and Restated Certificate of Incorporation
eliminates, to the fullest extent permitted by Delaware law, liability of a
director to the Company or its stockholders for monetary damages for breach of
the director's fiduciary duty of care except for liability where the director
(a) breaches his or her duty of loyalty to the Company or its shareholders, (b)
fails to act in good faith or engages in intentional misconduct or knowing
violation of law, (c) authorized a payment of an illegal dividend or stock
repurchase, or (d) obtains an improper personal benefit. While liability for
monetary damages has been eliminated, equitable remedies such as injunctive
relief or rescission remain available. In addition, a director is not relieved
of his or her responsibilities under any other law, including the federal
securities laws.

          Insofar as indemnification by the Company for liabilities arising
under the Securities Act, may be permitted to directors, officers, and
controlling persons of the Company pursuant to the foregoing, the Company has
been advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.

Item 7.   Exemption From Registration Claimed.

          Not applicable.

                                       2
<PAGE>

Item 8.   Exhibits.

          We incorporate by reference the Exhibit Index which appears at the end
of this registration statement. That Index lists the exhibits to this
registration statement.

Item 9.   Undertakings.

          (a)  The Company hereby undertakes:

                    (1)  To file, during any period in which offers or sales are
               being made, a post-effective amendment to this registration
               statement:

                          (i)   To include any prospectus required by Section
                    10(a)(3) of the Securities Act of 1933;

                          (ii)  To reflect in the prospectus any facts or events
                    arising after the effective date of this registration
                    statement (or the most recent post-effective amendment
                    thereof) which, individually or in the aggregate, represent
                    a fundamental change in the information set forth in this
                    registration statement. Notwithstanding the foregoing, any
                    increase or decrease in volume of securities offered (if the
                    total dollar value of securities offered would not exceed
                    that which was registered) and any deviation from the low or
                    high end of the estimated maximum offering range may be
                    reflected in the form of prospectus filed with the
                    Commission pursuant to Rule 424(b) if, in the aggregate, the
                    changes in volume and price represent no more than a 20
                    percent change in the maximum aggregate offering price set
                    forth in the "Calculation of Registration Fee" table in the
                    effective registration statement;

                         (iii)  To include any material information with respect
                    to the plan of distribution not previously disclosed in this
                    registration statement or any material change to such
                    information in this registration statement;

               provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do
               not apply if the information required to be included in a post-
               effective amendment by those paragraphs is contained in periodic
               reports filed by the Company pursuant to Section 13 or Section
               15(d) of the Securities Exchange Act of 1934 that are
               incorporated by reference in this registration statement.

                    (2)  That, for the purpose of determining any liability
               under the Securities Act of 1933, each such post-effective
               amendment shall be deemed to be a new registration statement
               relating to the securities offered therein, and the offering of
               such securities at that time shall be deemed to be the initial
               bona fide offering thereof.

                    (3)  To remove from registration by means of a post-
               effective amendment any of the securities being registered which
               remain unsold at the termination of the offering.

          (b)      The Company hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
Company's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in this
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

          (c)-(g)  Not applicable.

          (h)      Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the Company pursuant to the foregoing provisions, or otherwise, the

                                       3
<PAGE>

Company has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the
Securities Act of 1933 and is, therefore, unenforceable. In the event that a
claim for indemnification against such liabilities (other than the payment by
the Company of expenses incurred or paid by a director, officer or controlling
person of the Company in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Company will, unless in the
opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.

     (i)-(j)  Not applicable.

                                       4
<PAGE>

                                  SIGNATURES

               Pursuant to the requirements of the Securities Act of 1933, the
Company certifies that it has reasonable grounds to believe that it meets all of
the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Skokie, State of Illinois, on September 22, 1999.

                                        PATHOGENESIS CORPORATION


                                        By       /s/ Alan R. Meyer
                                           -------------------------------
                                                     Alan R. Meyer
                                                Executive Vice President

     Pursuant to the requirements of the Securities Act of 1933, this
registration statement has been signed by the following persons in the
capacities and on the dates indicated.

/s/ Alan R. Meyer        Executive Vice President, Chief      September 22, 1999
- -----------------------
Alan R. Meyer            Financial Officer and Director
                         (Principal Financial and
                          Accounting Officer)

Wilbur H. Gantz          Chairman, Chief Executive     )
                         Officer, President and        )
                         Director (Principal           )
                         Executive Officer)            )
                                                       )
John Gordon              Director                      )
                                                       )
                                                       )
Elizabeth M. Greetham    Director                      )  By:  /s/ Alan R. Meyer
                                                       )     -------------------
                                                       )        Alan R. Meyer
                                                       )       Attorney-in-Fact
Michael J. Montgomery    Director                      )      September 22, 1999
                                                       )
                                                       )
Arthur W. Nienhuis       Director                      )
                                                       )
                                                       )
Talat M. Othman          Director                      )
                                                       )
                                                       )
Eugene L. Step           Director                      )
                                                       )
                                                       )
James R. Tobin           Director                      )
                                                       )
                                                       )
Fred Wilpon              Director                      )

                                       5
<PAGE>

(Being the principal executive officer, the principal financial and accounting
officer and a majority of the directors of PathoGenesis Corporation.)

ORIGINAL POWER OF ATTORNEY AUTHORIZING WILBUR H. GANTZ AND ALAN R. MEYER TO
EXECUTE THIS REGISTRATION STATEMENT FOR EACH OF MS. GREETHAM AND MESSRS. GANTZ,
GORDON, MEYER, MONTGOMERY, NIENHUIS, OTHMAN, STEP, TOBIN AND WILPON HAS BEEN
EXECUTED AND FILED WITH THE SECURITIES AND EXCHANGE COMMISSION.

                                       6
<PAGE>

                                 Exhibit Index

          The following are filed as part of this registration statement.

Exhibit Number                          Description of Document
- --------------                          -----------------------

      4.1           Composite Certificate of Incorporation of PathoGenesis
                    Corporation, as amended (incorporated reference to Exhibit
                    3.1(d) of quarterly report on Form 10-Q for the three months
                    ended March 31, 1998, File No. 0-27150).

      4.1(a)        Amended and Restated Certificate of Incorporation, as
                    amended (incorporated by reference to Exhibit 3.1 to
                    registration statement on Form S-1, Registration No.
                    333-22297).

      4.1(b)        Certificate of Amendment of Amended and Restated Certificate
                    of Incorporation (incorporated by reference to Exhibit
                    4.1(b) to registration statement on Form S-8, Registration
                    No. 333-45571).

      4.2           By-laws of the Company, as amended through June 3, 1999
                    (incorporated by reference to Exhibit 3.2 to quarterly
                    report on Form 10-Q for the three months ended June 30,
                    1999, File No. 0-27150).

      4.3           Certificate of Designations (incorporated by reference to
                    Exhibit 4.1(b) to registration statement on Form S-8,
                    Registration No. 333-45571).

      4.4           PathoGenesis Corporation 1999 Employee Stock Option Plan
                    (incorporated by reference to Exhibit 4.5 to quarterly
                    report on Form 10-Q for the three months ended March 31,
                    1999, File No. 0-27150).

      4.4(a)        Form of Stock Option Agreement for PathoGenesis Corporation
                    1999 Employee Stock Option Plan (incorporated by reference
                    to Exhibit 4.9 to quarterly report on Form 10-Q for the
                    three months ended June 30, 1999, File No. 0-27150).

      4.5           Rights Agreement, dated as of June 25, 1997, between
                    PathoGenesis Corporation and Harris Trust and Savings Bank
                    as Rights Agent, including the form of Right Certificate as
                    Exhibit B (incorporated by reference to Exhibit 1 to current
                    report on Form 8-K filed on July 10, 1997, File No.
                    0-27150).

      4.5(a)        First Amendment, dated as of March 8, 1998, to Rights
                    Agreement between PathoGenesis Corporation and Harris Trust
                    and Savings Bank, as Rights Agent (incorporated by reference
                    to Exhibit 4.1(bb) to annual report on Form 10-K for 1997,
                    File No. 0-27150).

      4.5(b)        Amendment of Rights Plan, dated as of April 13, 1999,
                    between PathoGenesis Corporation and Harris Trust and
                    Savings Bank as Rights Agent (incorporated by reference to
                    Exhibit 4.1(bbb) to amendment to registration statement on
                    Form 8-A/A, filed on April 15, 1999, File No. 0-27150).

       5            Opinion of Bell, Boyd & Lloyd.

       23.1         Consent of KPMG LLP.

       23.2         Consent of Bell, Boyd & Lloyd (included in Exhibit 5).

        24          Power of Attorney

<PAGE>

                                                                       EXHIBIT 5

                              BELL, BOYD & LLOYD
                          Three First National Plaza
                      70 West Madison Street, Suite 3300
                         Chicago, Illinois 60602-4207
                        312-372-1121 Fax: 312-372-2098


                              September 21, 1999



PathoGenesis Corporation
201 Elliott Avenue West
Seattle, Washington, 98119

           PathoGenesis Corporation 1999 Employee Stock Option Plan
                      Registration Statement on Form S-8
                  ------------------------------------------

Ladies and Gentlemen:

          We have acted as counsel to PathoGenesis Corporation, a Delaware
corporation (the "Company"), in connection with the preparation, execution and
filing of the registration statement on Form S-8 of the Company (the
"Registration Statement"), which covers 600,000 shares of common stock, par
value $.001 per share, of the Company (the "Shares"), offered under the
Company's 1999 Employee Stock Option Plan (the "Plan"). We have examined
originals, or copies certified or otherwise identified to our satisfaction, of
the Plan and such other documents, corporate and other records, certificates
and other papers as we deemed it necessary to examine for the purposes of this
opinion.

          Based upon the foregoing, we are of the opinion that:

          1.   The Company is a corporation duly organized and legally existing
               under the law of the State of Delaware.

          2.   The Company has taken all action necessary to authorize (i) the
               Plan, (ii) the offer for sale of the Shares pursuant to the Plan,
               and (iii) the issuance of the shares of its common stock, $.001
               par value, in accordance with the Plan.

          3.   The Shares when issued in accordance with the Plan will, upon
               such issuance, constitute legally issued, fully paid and
               nonassessable shares of common stock, $.001 par value, of the
               Company.

<PAGE>

PathoGenesis Corporation
September 21, 1999
Page 2

          We hereby consent to the filing of this Opinion Letter as an exhibit
to the Registration Statement for the registration of the Shares under the
Securities Act of 1933. In giving this consent, we do not admit that we are
within the category of persons whose consent is required by Section 7 of the
Securities Act of 1933.


                                              Very truly yours,

                                              BELL, BOYD & LLOYD



<PAGE>

                                                                    EXHIBIT 23.1
                                                                    ------------

              Consent of Independent Certified Public Accountants
              ---------------------------------------------------

The Board of Directors
PathoGenesis Corporation

We consent to the use of our report in this registration statement on Form S-8
of our report dated January 25, 1999, except as to note 11, which is as of March
29, 1999, relating to the consolidated balance sheets of PathoGenesis
Corporation and subsidiary as of December 31, 1998 and 1997, and the related
consolidated statements of operations, stockholders' equity, and cash flows for
each of the years in the three-year period ended December 31, 1998, which report
appears in the December 31, 1998, annual report on Form 10-K of PathoGenesis
Corporation, incorporated herein by reference.


                                KPMG LLP
Seattle, Washington
September 22, 1999

<PAGE>

                                                                      EXHIBIT 24

                               POWER OF ATTORNEY

     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints Wilbur H. Gantz and Alan R. Meyer, or any one of
them, his/her true and lawful attorney-in-fact and agent, with full power of
substitution and resubstitution, for him/her and in his/her name, place, and
stead, in any and all capacities, to sign any and all pre- or post-effective
amendments to this Registration Statement, and to file the same with all
exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange commission, granting unto said attorney-in-fact and
agent, full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises, as fully to all
intents and purposes as he/she might or could do in person, hereby ratifying and
confirming all that said attorney-in-fact and agent, or their, his/her
substitutes, may lawfully do or cause to be done by virtue hereof.

<TABLE>
<CAPTION>
      SIGNATURE                                TITLE                            DATE
      ---------                                -----                            ----
<S>                              <C>                                       <C>
/s/ Wilbur H. Gantz              Chairman, Chief Executive Officer,        August 26, 1999
- ------------------------
Wilbur H. Gantz                  President and Director
                                 (Principal Executive Officer)

/s/ Alan R. Meyer                Executive Vice President, Chief           August 26, 1999
- ------------------------
Alan R. Meyer                    Financial Officer and Director
                                 (Principal Financial and
                                 Accounting Officer)

/s/ John Gordon                  Director                                  August 26, 1999
- ------------------------
John Gordon

/s/ Elizabeth M. Greetham        Director                                  August 26, 1999
- --------------------------
Elizabeth M. Greetham

/s/ Michael J. Montgomery        Director                                  August 26, 1999
- ---------------------------
Michael J. Montgomery

/s/ Arthur W. Nienhuis           Director                                  September 6, 1999
- ---------------------------
Arthur W. Nienhuis

/s/ Talat M. Othman              Director                                  August 26, 1999
- ---------------------------
Talat M. Othman

/s/ Eugene L. Step               Director                                  August 26, 1999
- ---------------------------
Eugene L. Step

/s/ James R. Tobin               Director                                  August 26, 1999
- ---------------------------
James R. Tobin

/s/ Fred Wilpon                  Director                                  September 2, 1999
- ---------------------------
Fred Wilpon
</TABLE>


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