ATLANTIC PHARMACEUTICALS INC
S-3, 1997-08-26
PHARMACEUTICAL PREPARATIONS
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<PAGE>

       AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON AUGUST 26, 1997
                                                 REGISTRATION NO. 333-
                                                                      ----------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                          SECURITIES AND EXCHANGE COMMISSION
                                WASHINGTON, D.C. 20549
                                ----------------------
                                       FORM S-3

                                REGISTRATION STATEMENT
                                        UNDER
                              THE SECURITIES ACT OF 1933
                              --------------------------

                            ATLANTIC PHARMACEUTICALS, INC.
                (Exact Name of Registrant as Specified in Its Charter)
                            -----------------------------

            DELAWARE                                        36-3898269
(State or Other Jurisdiction of                          (I.R.S. Employer
Incorporation or Organization)                         Identification Number)

                          1017 MAIN CAMPUS DRIVE, SUITE 3900
                            RALEIGH, NORTH CAROLINA 27606
                                    (919) 513-7020
      (Address, Including Zip Code, and Telephone Number, Including Area Code,
                      of Registrant's Principal Executive Offices


                                   JON D. LINDJORD
                        PRESIDENT AND CHIEF EXECUTIVE OFFICER
                            ATLANTIC PHARMACEUTICALS, INC.
                          1017 MAIN CAMPUS DRIVE, SUITE 3900
                            RALEIGH, NORTH CAROLINA 27606
                                    (919) 513-7020
         (Name, Address, Including Zip Code, and Telephone Number, Including
                           Area Code, of Agent for Service)
                           --------------------------------


                                      COPIES TO:
                                      ----------
                              J. STEPHAN DOLEZALEK, ESQ.
                           BROBECK, PHLEGER & HARRISON LLP
                                TWO EMBARCADERO PLACE
                                    2200 GENG ROAD
                             PALO ALTO, CALIFORNIA 94303
                                    (415) 424-0160
                                    --------------

        APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:
 AS SOON AS PRACTICABLE AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.

                                    --------------

    If the only securities being registered on this form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box:  / /

    If any of the securities being registered on this form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, as amended, check the following box:  /x/

    If this form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering:   / /

    If this form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering:  / /

    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box:   / /

                           CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>

- ------------------------------------------------------------------------------------------------------------------------------------
                                                                          Proposed
                                                                           Maximum           Proposed Maximum
Title of Shares                                           Amount to be   Aggregate Price     Aggregate Offering        Amount of
to be Registered(1)                                        Registered     Per Share(1)            Price(1)       Registration Fee(2)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                                       <C>            <C>                 <C>                 <C>
Common Stock, $0.001 par value per share ("Common Stock")   250,000          $7.00              $1,750,000            $531.00
- ------------------------------------------------------------------------------------------------------------------------------------
- ------------------------------------------------------------------------------------------------------------------------------------
FOOTNOTES ON FOLLOWING PAGE
</TABLE>

<PAGE>

(1) Estimated solely for the purpose of calculating the registration fee.  Fee
    calculated upon the basis of the average of the high and low sales prices
    of the Company's Common Stock as reported on the Nasdaq SmallCap Market on
    August 22, 1997 of $7.00, which date is within five business days prior to
    the date of the filing of this Registration Statement.
(2) Calculated pursuant to Rule 457(c) of the Securities Act based on an
    estimate of the maximum offering price.

    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT THAT SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT, OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE
ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A), MAY
DETERMINE.
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

<PAGE>

PROSPECTUS (Subject to Completion)
Dated August 26, 1997


                            ATLANTIC PHARMACEUTICALS, INC.


                           250,000 shares of Common Stock,
                      offered by certain Selling Securityholders

                                   ----------------

    This prospectus (the "Prospectus") relates to the public offering, which is
not being underwritten, of 250,000 shares (the "Shares") of Common Stock, par
value $0.001 per share (the "Common Stock"), of Atlantic Pharmaceuticals, Inc.,
a Delaware corporation ("Atlantic" or the "Company").  All of the Shares may be
offered by certain stockholders of the Company or by pledgees, donees,
transferees or other successors in interest that receive such shares as a gift,
partnership distribution or other non-sale related transfer (the "Selling
Securityholders").  The Shares were received by certain Selling Securityholders
in a private placement transaction of the Company and were issued pursuant to an
exemption from the registration requirements of the Securities Act of 1933, as
amended (the "Securities Act"), provided by Section 4(2) thereof.  The Shares
are being registered by the Company pursuant to a registration rights agreement
with certain Selling Securityholders.  See "Description of Securities" and "Plan
of Distribution."

    The Shares may be offered by the Selling Securityholders from time to time
in transactions on the Nasdaq SmallCap Market ("Nasdaq"), in privately
negotiated transactions, or by a combination of such methods of sale, at fixed
prices that may be changed, at market prices prevailing at the time of sale, at
prices related to such prevailing market prices or at negotiated prices.  The
Shares may be sold by one or more of the following:  (a) a block trade in which
the broker or dealer so engaged will attempt to sell the Shares as agent but may
position and resell a portion of the block as principal to facilitate the
transaction, (b) purchases by a broker or dealer as principal and resale by such
broker or dealer for its account pursuant to this Prospectus and (c) ordinary
brokerage transactions and transactions in which the broker solicits purchases.
The Selling Securityholders may effect such transactions by selling the Shares
to or through broker-dealers and such broker-dealers may receive compensation in
the form of discounts, concessions or commissions from the Selling
Securityholders or the purchasers of the Shares for whom such broker-dealers may
act as agent or to whom they sell as principal or both (which compensation to a
particular broker-dealer might be in excess of customary commissions).  In
addition, any securities covered by this Prospectus which qualify for sale
pursuant to Rule 144 may be sold under Rule 144 promulgated under the Securities
Act rather than pursuant to this Prospectus.  The Company will not receive any
of the proceeds from the sale of the Shares by the Selling Securityholders.  The
Company has agreed to bear certain expenses in connection with the registration
and sale of the Shares being offered by the Selling Securityholders and to
indemnify the Selling Securityholders against certain liabilities, including
liabilities under the Securities Act.  See "Plan of Distribution."

    The Units, Common Stock and Redeemable Warrants of the Company are traded
on The Nasdaq SmallCap Market tier of The Nasdaq Stock Market under the symbols
"ATLCU," "ATLC" and "ATLCW," respectively.  On August 22, 1997, the last sale
price for the Units, Common Stock and Redeemable Warrants as quoted on Nasdaq
was $8.75, $6.75 and $1.75, respectively, per security.

                                   ----------------

    The Selling Securityholders and any broker-dealers or agents that
participate with the Selling Securityholders in the distribution of the Shares
may be deemed to be "underwriters" within the meaning of Section 2(11) of the
Securities Act, and any commissions received by them and any profit on the
resale of the Shares purchased by them may be deemed to be underwriting
commissions or discounts under the Securities Act.

                                   ----------------

            THE SECURITIES OFFERED HEREBY INVOLVE A HIGH DEGREE OF RISK.
                       SEE "RISK FACTORS" BEGINNING ON PAGE 3.

                                   ----------------

    THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
         EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
            SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES
        COMMISSION PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS.
             ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.


                   The date of this Prospectus is August ___, 1997.

<PAGE>

    No dealer, salesperson or other person has been authorized to give any
information or to make any representations other than those contained in this
Prospectus and, if given or made, such information or representations must not
be relied upon as having been authorized by the Company, any Selling
Securityholders or by any other person.  This Prospectus does not constitute an
offer to sell or a solicitation of an offer to buy any securities other than the
shares of Common Stock offered hereby, nor does it constitute an offer to sell
or a solicitation of an offer to buy any of the shares offered hereby to any
person in any jurisdiction in which such offer or solicitation would be
unlawful.  Neither the delivery of this Prospectus nor any sale made hereunder
shall under any circumstances create any implication that the information
contained herein is correct as of any date subsequent to the date hereof.

                             AVAILABLE INFORMATION

    Atlantic was incorporated in the State of Delaware on May 18, 1993 and
commenced operations on July 13, 1993.  As used in this Prospectus, unless the
context requires otherwise, the "Company" means Atlantic Pharmaceuticals, Inc.
and its subsidiaries.  The Company's principal executive offices are located at
1017 Main Campus Drive, Suite 3900, Raleigh, North Carolina 27606.  The
Company's telephone number at that address is (919) 513-7020.  The Company's
Units, Common Stock, and Redeemable Warrants are quoted on Nasdaq under the
respective symbols "ATLCU," "ATLC" and "ATLCW."

    Atlantic is subject to the information requirements of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), and in accordance
therewith, is required to file periodic reports, proxy materials and other
information with the Securities and Exchange Commission (the "Commission").
Reports, proxy statements and other information can be inspected and copied at
the public reference facilities maintained by the Commission at Room 1024,
Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549, or at its
regional offices located at Suite 1400, Northwest Atrium Center, 500 West
Madison Street, Chicago, Illinois 60661 and at Room 1400, 75 Park Place, New
York, New York 10007.  Copies of such materials may also be obtained from the
Public Reference Section of the Commission, 450 Fifth Street, N.W., Washington,
DC 20549, at prescribed rates.  In addition, the Commission maintains a World
Wide Web site that contains reports, proxy and information statements and other
information regarding issuers, including the Company, that file electronically
with the Commission.  Such Web site can be found at http://www.sec.gov.  The
materials described above may also be inspected at the offices of Nasdaq
Operations, 1735 K Street, N.W., Washington, DC 20006.

    This Prospectus, which constitutes a part of a Registration Statement on
Form S-3 (the "Registration Statement") filed by the Company with the Commission
under the Securities Act, omits certain of the information set forth in the
Registration Statement and the exhibits and schedules thereto.  For further
information with respect to the Company and the Shares offered hereby, reference
is made to the Registration Statement and the exhibits and schedules filed as a
part thereof.  Statements contained in this Prospectus concerning the contents
of any contract or any other document referred to are not necessarily complete;
reference is made in each instance to the copy of such contract or document
filed as an exhibit to the Registration Statement.  Each such statement is
qualified in all respects by such reference to such exhibit.  The Registration
Statement, including all exhibits and schedules thereto, may be inspected
without charge of the Commission's principal office in Washington, D.C., and
copies of all or any part thereof may be obtained from such office after payment
of fees prescribed by the Commission.

                     INFORMATION INCORPORATED BY REFERENCE

    The following documents filed by the Company with the Commission (File No.
0-19750) pursuant to the Exchange Act are incorporated by reference in this
Prospectus:

    1.   The Company's Annual Report on Form 10-KSB for the fiscal year ended
         December 31, 1996, Quarterly Report on Form 10-QSB for the fiscal
         quarter ended March 31, 1997, Current Report on Form 8-K filed with
         the Commission on June 9, 1997, and Quarterly Report on Form 10-QSB
         for the fiscal quarter ended June 30, 1997;

    2.   The Company's definitive Proxy Statement dated May 8, 1997 filed in
         connection with the Company's 1997 Annual Meeting of Stockholders;

    3.   The description of the Company's securities contained in the Company's
         Registration Statement on Form 8-A filed under the Exchange Act on
         November 27, 1995, including any amendment or report filed for the
         purpose of updating such description.

    All documents filed by the Company pursuant to Sections 13(a), 13(c), 14 or
15(d) of the Exchange Act subsequent to the date of this Prospectus but prior to
the termination of the offering to which this Prospectus relates shall be deemed
to be incorporated by reference in this Prospectus and to be part hereof from
the date of filing of such documents.  Any statement contained in a document
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this Prospectus to the extent that a statement contained herein
or in any other subsequently filed document which also is incorporated herein
modifies or supersedes such statement.  Any statement so modified or superseded
shall not be deemed, in its unmodified form, to constitute a part of this
Prospectus.

    Upon written or oral request, the Company will provide without charge to
each person to whom a copy of the Prospectus is delivered a copy of the
documents incorporated by reference herein (other than exhibits to such
documents unless such exhibits are specifically incorporated by reference
therein).  Requests should be submitted in writing or by telephone at (919)
513-7020 to Director of Investor Relations, Atlantic Pharmaceuticals, Inc., at
the principal executive offices of the Company, 1017 Main Campus Drive, Suite
3900, Raleigh, North Carolina 27606.


                                          2

<PAGE>

                                 RISK FACTORS

    AN INVESTMENT IN THE SECURITIES OFFERED HEREBY IS SPECULATIVE IN NATURE,
INVOLVES A HIGH DEGREE OF RISK AND SHOULD NOT BE MADE BY AN INVESTOR WHO CANNOT
AFFORD THE LOSS OF HIS ENTIRE INVESTMENT.  THE FOLLOWING RISK FACTORS SHOULD BE
CONSIDERED CAREFULLY IN ADDITION TO THE OTHER INFORMATION CONTAINED OR
INCORPORATED BY REFERENCE IN THIS PROSPECTUS BEFORE PURCHASING THE SECURITIES
OFFERED HEREBY.  IN ADDITION TO THE HISTORICAL INFORMATION CONTAINED HEREIN, THE
DISCUSSION IN THIS PROSPECTUS CONTAINS CERTAIN FORWARD-LOOKING STATEMENTS,
WITHIN THE MEANING OF SECTION 27A OF THE SECURITIES ACT AND SECTION 27E OF THE
EXCHANGE ACT, THAT INVOLVE RISKS AND UNCERTAINTIES, SUCH AS STATEMENTS OF THE
COMPANY'S PLANS, OBJECTIVES, EXPECTATIONS AND INTENTIONS.  THE CAUTIONARY
STATEMENTS MADE IN THIS PROSPECTUS SHOULD BE READ AS BEING APPLICABLE TO ALL
RELATED FORWARD-LOOKING STATEMENTS WHEREVER THEY APPEAR IN THIS PROSPECTUS.  THE
COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY FROM THOSE DISCUSSED HEREIN.
FACTORS THAT COULD CAUSE OR CONTRIBUTE TO SUCH DIFFERENCES INCLUDE THOSE
DISCUSSED BELOW AS WELL AS THOSE CAUTIONARY STATEMENTS AND OTHER FACTORS SET
FORTH ELSEWHERE HEREIN.

DEVELOPMENT STAGE COMPANIES; HISTORY OF OPERATING LOSSES; ACCUMULATED DEFICIT;
UNCERTAINTY OF FUTURE PROFITABILITY

The technologies and products under development by the Company are in the
research and development stage and no operating revenue, outside of grant
revenues, have been generated to date.  The Company does not expect to generate
any revenues in the near future.  As a result, the Company must be evaluated in
light of the problems, delays, uncertainties and complications encountered in
connection with newly established businesses.  The Company has incurred
operating losses since its inception.  As of June 30, 1997, the Company's
working capital and accumulated deficit were $1,988,899 and $11,276,353,
respectively.  Operating losses have resulted principally from costs incurred in
identifying and acquiring the technologies under development, research and
development activities and from general and administrative costs.  The Company
expects to incur significant operating losses over the next several years,
primarily due to continuation and expansion of its research and development
programs, including preclinical studies and clinical trials for its
pharmaceutical products under development.  The Company's ability to achieve
profitability depends upon its ability to develop pharmaceutical and medical
device products, obtain regulatory approval for its proposed products and enter
into agreements for product development, manufacturing and commercialization.
There can be no assurance that the Company will ever achieve significant
revenues or profitable operations from the sale of its proposed products.

QUALIFICATION OF AUDITOR'S OPINION

The Company's independent accountants have included an explanatory paragraph in
their report on the Company's financial statements at December 31, 1996,
included in the Company's 1996 Annual Report on Form 10-KSB, which states that
the Company has suffered recurring losses from operations and has limited
capital resources, both of which raise substantial doubt about the Company's
ability to continue as a going concern.

NEED FOR ADDITIONAL FINANCING; ISSUANCE OF SECURITIES BY THE COMPANY AND ITS
SUBSIDIARIES; FUTURE DILUTION

The Company will require, and is constantly considering potential sources for,
substantial additional financing to continue its research, to complete its
product development and to manufacture and market any products that may be
developed.  Based solely upon its currently existing consulting, license,
sponsored research and employment agreements, the Company currently anticipates
that it will spend all of its current cash reserves by late 1999.  There can be
no assurance, however, that the Company's current cash reserves will not be
expended prior to that time.  The Company anticipates that further funds may be
raised at any time through additional public or private debt or equity
financings conducted either by the Company or by one or more of its
subsidiaries, or through collaborative ventures entered into between the Company
or one or more of its subsidiaries and a corporate partner.  There can be no
assurance that the Company will be able to obtain additional financing or that
such financing, if available, can be obtained on terms acceptable to the
Company.  If additional financing is not otherwise available, the Company will
be required to modify its business development plans or reduce or cease certain
or all of its operations.  In such event, holders of securities of the Company
will, in all likelihood, lose their entire investment.

Although the Company and each of its subsidiaries will seek to enter into
collaborative ventures with corporate sponsors to fund some or all of such
activities, as well as to manufacture or market the products which may be
successfully developed, neither the Company nor any of its subsidiaries
currently has any such arrangements with corporate sponsors, and there can be no
assurance that the Company or any of its subsidiaries will be able to enter into
such ventures on favorable terms, if at all.  In addition, no assurance can be
given that the Company or any of its subsidiaries will be able to complete a
subsequent private placement or public offering of their securities.  Failure by
the Company or any of its subsidiaries to enter into such collaborative ventures
or to receive additional funding


                                          3

<PAGE>

to complete its proposed product development programs either through a public
offering or a private placement would have a material adverse effect on the
Company.

In the event that the Company obtains any additional funding, such financings
may have a dilutive effect on the holders of the Company's securities.  In
addition, if one or more of the Company's subsidiaries raises additional funds
through the issuance and sale of its equity securities, the interest of the
Company and its stockholders in such subsidiary or subsidiaries, as the case may
be, could be diluted and there can be no assurance that the Company will be able
to maintain its majority interest in any or all of its current subsidiaries.  In
addition, the interest of the Company and its stockholders in each subsidiary
will be diluted or subject to dilution to the extent any such subsidiary issues
shares or options to purchase shares of its capital stock to employees,
directors, consultants and others.  In the event that the Company's voting
interest in any of its current subsidiaries falls below 50%, the Company may not
be able to exercise an adequate degree of control over the affairs and policies
of such subsidiary as currently being exercised.  In addition, the Company has
outstanding currently exercisable warrants to purchase 3,826,750 shares of its
Common Stock at exercise prices ranging from $5.50 to $10.00, and the exercise
price for most of such warrants is below the per share price of the Common Stock
as currently quoted on the Nasdaq SmallCap Market ("Nasdaq").  The exercise of
such warrants, if any, may dilute the value of the Common Stock.

NO DEVELOPED OR APPROVED PRODUCTS

To achieve profitable operations, the Company, alone or with others, must
successfully develop, obtain regulatory approval for, introduce and market its
products under development.  The great majority of the preclinical and clinical
development work for the products under development of the Company remains to be
completed.  The Company has not generated, nor is it expected to generate in the
near future, any operating revenues.  In addition, the Company has no
manufacturing or marketing facilities nor any contracts with any commercial
manufacturing or marketing entities.  No assurance can be given that any of its
product development efforts will be successfully completed, that required
regulatory approvals will be obtained, or that any such products, if developed
and introduced, will be successfully marketed or achieve market acceptance.

TECHNOLOGICAL UNCERTAINTY AND EARLY STAGE OF PRODUCT DEVELOPMENT

The technologies and products which the Company intends to develop are in the
early stages of development, require significant further research, development
and testing and are subject to the risks of failure inherent in the development
of products based on innovative or novel technologies.  These risks include the
possibility that any or all of the Company's proposed technologies and products
will be found to be ineffective or unsafe, that such technologies and products
once developed, although effective, are uneconomical to market, that third
parties hold proprietary rights that preclude the Company from marketing such
technologies and products or that third parties market superior or equivalent
technologies and products.

The Company's agreements with licensors do not contain any representations by
the licensors as to the safety or efficacy of the inventions or discoveries
covered thereby.  The Company is unable to predict whether the research and
development activities it is funding will result in any commercially viable
products or applications.  Further, due to the extended testing required before
marketing clearance can be obtained from the United States Food and Drug
Administration (the "FDA") or other similar agencies, the Company is not able to
predict with any certainty, when, if ever, the Company will be able to
commercialize any of its proposed technologies or products.

GOVERNMENT REGULATION; NO ASSURANCE OF PRODUCT APPROVAL

The Company's proposed products and technologies are in very early stages of
development.  The research, preclinical development, clinical trials, product
manufacturing and marketing to be conducted by the Company is subject to
regulation by the FDA and similar health authorities in foreign countries.  FDA
approval of the Company's products, as well as the manufacturing processes and
facilities, if any, used to produce such products will be required before such
products may be marketed in the U.S. The process of obtaining approvals from the
FDA is costly, time consuming and often subject to unanticipated delays.  There
can be no assurance that approvals of the Company's proposed products, processes
or facilities will be granted on a timely basis, or at all.  In addition, new
government regulations may be established that could delay or prevent regulatory
approval of the Company's products under development.  Any future failure to
obtain or delay in obtaining any such approval will materially and adversely
affect the ability of the Company to market its proposed products and the
business, financial condition and results of operations of the Company.

Even if regulatory approval of the Company's proposed products is granted, such
approval may include significant limitations on indicated uses for which any
such products could be marketed.  Further, even if such regulatory


                                          4

<PAGE>

approvals are obtained, a marketed drug or device and its manufacturer are
subject to continued review, and later discovery of previously unknown problems
may result in restrictions on such product or manufacturer, including withdrawal
of the product from the market.  Failure of the Company to obtain and maintain
regulatory approval of its proposed products, processes or facilities would have
a material adverse effect on the business, financial condition and results of
operations of the Company.

The Company's proposed products and technologies may also be subject to certain
other federal, state and local government regulations, including, but not
limited to, the Federal Food, Drug and Cosmetic Act, the Environmental
Protection Act, the Occupational Safety and Health Act and state, local and
foreign counterparts to certain of such acts.  The Company intends to develop
its business to strategically address regulatory needs.  However, the Company
cannot predict the extent of the adverse effect on its business or the financial
and other costs that might result from any government regulations arising out of
future legislative, administrative or judicial action.

SECURITIES LAW RESTRICTIONS ON THE EXERCISE OF REDEEMABLE WARRANTS

A holder of Redeemable Warrants will have the right to exercise such Redeemable
Warrants for the purchase of shares of Common Stock only if the Company has
filed with the Securities and Exchange Commission a current prospectus meeting
the requirements of the Securities Act covering the issuance of such shares of
Common Stock issuable upon exercise of the Redeemable Warrants and only if the
issuance of such shares has been registered or qualified, or is deemed to be
exempt from registration or qualification under, the securities laws of the
state of residence of the holder of the Redeemable Warrant.  The Company has
undertaken and intends to file and keep effective and current a prospectus which
will permit the purchase and sale of the Common Stock underlying the Redeemable
Warrants, but there can be no assurance that the Company will be able to do so.
Although the Company intends to seek to qualify for sale the shares of Common
Stock underlying the Redeemable Warrants in those states in which the securities
are to be offered, no assurance can be given that such qualification will occur.
The Redeemable Warrants may be deprived of any value if a prospectus covering
the shares issuable upon the exercise thereof is not kept effective and current
or if such underlying shares are not, or cannot be, registered in the applicable
states.  See "Description of Securities--Redeemable Warrants."

DEPENDENCE ON LICENSE AND SPONSORED RESEARCH AGREEMENTS

The Company depends on license agreements that form the basis of its proprietary
technology, and, with the exception of its majority-owned subsidiary, Optex
Opthalmologics, Inc., a Delaware corporation ("Optex"), the Company relies on
sponsored research agreements for its research and development efforts.  The
license agreements that have been entered into by the Company typically require
the use of due diligence in developing and bringing products to market and the
payment of certain milestone amounts that in some instances may be substantial.
With the exception of Optex, the Company is also obligated to make royalty
payments on the sales, if any, of products resulting from such licensed
technology and, is responsible for the costs of filing and prosecuting patent
applications and maintaining issued patents.  With the exception of Optex, the
Company does not currently have laboratory facilities, and, accordingly, certain
research and development activities of the Company is intended to be conducted
by universities or other institutions pursuant to sponsored research agreements.
The sponsored research agreements entered into and contemplated to be entered
into by the Company generally require periodic payments on an annual, quarterly
or monthly basis.

If the Company does not meet its financial, development or other obligations
under either its license agreements or its sponsored research agreements in a
timely manner, the Company could lose the rights to its proprietary technology
or the right to have the applicable university or institution conduct its
research and development efforts.  If the rights of the Company under its
license or sponsored research agreements are terminated, such termination could
have a material adverse effect on the business and research and development
efforts of the Company.

UNCERTAINTY REGARDING PATENTS AND PROPRIETARY RIGHTS

The success of the Company will depend in large part on its or its licensors'
ability to obtain patents, defend their patents, maintain trade secrets and
operate without infringing upon the proprietary rights of others, both in the
United States and in foreign countries.  The patent position of firms relying
upon biotechnology is highly uncertain and involves complex legal and factual
questions.  To date there has emerged no consistent policy regarding the breadth
of claims allowed in biotechnology patents or the degree of protection afforded
under such patents.  The Company relies on certain United States patents and
pending United States and foreign patent applications relating to various
aspects of its products and processes.  All of these patents and patent
applications are owned by third parties and are licensed or sublicensed to the
Company.  The patent application and issuance process can be expected to take
several years and entail considerable expense to the Company, as it is
responsible for such costs under the terms of such


                                          5
<PAGE>

license agreements.  There can be no assurance that patents will issue as a
result of any such pending applications or that the existing patents and any
patents resulting from such applications will be sufficiently broad to afford
protection against competitors with similar technology.  In addition, there can
be no assurance that such patents will not be challenged, invalidated, or
circumvented, or that the rights granted thereunder will provide competitive
advantages to the Company.  The commercial success of the Company will also
depend upon avoiding infringement of patents issued to competitors.  A United
States patent application is maintained under conditions of confidentiality
while the application is pending, so the Company cannot determine the inventions
being claimed in pending patent applications filed by its competitors.
Litigation may be necessary to defend or enforce the Company's patent and
license rights or to determine the scope and validity of others' proprietary
rights.  Defense and enforcement of patent claims can be expensive and time
consuming, even, in those instances in which the outcome is favorable to the
Company, and can result in the diversion of substantial resources from the
Company's other activities.  An adverse outcome could subject the Company to
significant liabilities to third parties, require the Company to obtain licenses
from third parties, or require the Company to alter its products or processes,
or cease altogether any related research and development activities or product
sales, any of which may have a material adverse effect on the Company's
business, results of operations and financial condition.

The Company has certain licenses from third parties and in the future may
require additional licenses from other parties to develop, manufacture and
market commercially viable products effectively.  The Company's commercial
success will depend in part on obtaining and maintaining such licenses.  There
can be no assurance that such licenses can be obtained or maintained on
commercially reasonable terms, if at all, that the patents underlying such
licenses will be valid and enforceable or that the proprietary nature of the
patented technology underlying such licenses will remain proprietary.

The Company relies substantially on certain technologies that are not patentable
or proprietary and are therefore available to its competitors.  The Company also
relies on certain proprietary trade secrets and know-how that are not
patentable.  Although the Company has taken steps to protect its unpatented
trade secrets and know-how, in part through the use of confidentiality
agreements with its employees, consultants and contractors, there can be no
assurance that these agreements will not be breached, that the Company would
have adequate remedies for any breach, or that the Company's trade secrets will
not otherwise become known or be independently developed or discovered by
competitors.

The success of the Company is also dependent upon the skills, knowledge and
experience of its scientific and technical personnel.  The management and
scientific personnel of the Company has been recruited primarily from other
scientific companies, pharmaceutical companies and academic institutions.  In
some cases, these individuals may be continuing research in the same areas with
which they were involved prior to joining the Company.  Although the Company has
not received any notice of any claims and knows of no basis for any claims, it
could be subject to allegations of violation of trade secrets and similar claims
which could, regardless of merit, be time consuming, expensive to defend, and
have a material adverse effect on the Company's business, results of operations
and financial condition.

UNCERTAINTY OF PRODUCT PRICING AND REIMBURSEMENT; HEALTH CARE REFORM AND RELATED
MEASURES

The levels of revenues and profitability of pharmaceutical and/or biotechnology
products and companies may be affected by the continuing efforts of governmental
and third party payors to contain or reduce the costs of health care through
various means and the initiatives of third party payors with respect to the
availability of reimbursement.  For example, in certain foreign markets, pricing
or profitability of prescription pharmaceuticals is subject to government
control.  In the United States there have been, and the Company expects that
there will continue to be, a number of federal and state proposals to implement
similar governmental control.  Although the Company cannot predict what
legislative reforms may be proposed or adopted or what impact actions taken by
federal, state or private payors for health care goods and services in response
to any health care reform proposals or legislation may have on its business, the
existence and pendency of such proposals could have a material adverse effect on
the Company in general.  In addition, the Company's ability to commercialize
potential pharmaceutical and/or biotechnology products may be adversely affected
to the extent that such proposals have a material adverse effect on other
companies that are prospective collaborators with respect to any of the
Company's product candidates.

In addition, in both the United States and elsewhere, sales of medical products
and services are dependent in part on the availability of reimbursement to the
consumer from third party payors, such as government and private insurance
plans.  Third party payors are increasingly challenging the prices charged for
medical products and services.  If the Company succeeds in bringing one or more
products to the market, there can be no assurance that these products will be
considered cost effective and that reimbursement to the consumer will be
available or will be sufficient to allow the Company to sell its products on a
competitive basis.


                                          6

<PAGE>

DEPENDENCE UPON KEY PERSONNEL AND CONSULTANTS

The Company is highly dependent upon its officers and directors, as well as its
Scientific Advisory Board members, consultants and collaborating scientists.
Atlantic and its subsidiaries have an aggregate of only eight full-time
employees, four of whom are officers of Atlantic, and the loss of any of these
individuals would have a material adverse effect on the Company.  Although
Atlantic has entered into employment agreements with each of its officers, such
employment agreements do not contain provisions which would prevent such
employees from resigning their positions with Atlantic at any time.  The Company
does not maintain key-man life insurance policies on any of such key personnel.
Each of the Company's non-employee directors, advisors and consultants devotes
only a portion of his or her time to the Company's business.  The loss of
certain of these individuals could have a material adverse effect on the
Company.

The Company may seek to hire additional personnel.  Competition for qualified
employees among pharmaceutical and biotechnology companies is intense, and the
loss of any of such persons, or the inability to attract, retain and motivate
any additional highly skilled employees required for the expansion of the
Company's activities could have a material adverse effect on the Company.  There
can be no assurance that the Company will be able to retain its existing
personnel or to attract additional qualified employees.

The Company's scientific advisors are employed on a full time basis by unrelated
employers and some have one or more consulting or other advisory arrangements
with other entities which may conflict or compete with their obligations to the
Company.  Inventions or processes discovered by such persons, other than those
to which the licenses may relate, those to which the Company is able to acquire
licenses for or those which were invented while performing consulting services
on behalf of the Company pursuant to a proprietary information agreement or
utilizing the Company's facilities, will not become the property of the Company,
but will remain the property of such persons or of such persons' full-time
employers.  Failure to obtain needed patents, licenses or proprietary
information held by others could have a material adverse effect on the Company.

COMPETITION

The Company's business is characterized by intensive research efforts and
intense competition.  Many companies, research institutes, hospitals and
universities are working to develop products and technologies in the Company's
fields of research.  Most of these entities have substantially greater
financial, technical, manufacturing, marketing, distribution and other resources
than the Company.  Certain of such companies have experience in undertaking
testing and clinical trials of new or improved products similar in nature to
that which the Company is developing.  In addition, certain competitors have
already begun testing of similar compounds or processes and may introduce such
products or processes before the Company.  Accordingly, other companies may
succeed in developing products earlier than the Company or that are more
effective than those proposed to be developed by the Company.  Further, it is
expected that competition in the Company's fields will intensify.  There can be
no assurance that the Company will be able to compete successfully in the
future.

DEPENDENCE ON OTHERS FOR CLINICAL DEVELOPMENT OF, REGULATORY APPROVALS FOR AND
MARKETING OF PHARMACEUTICAL PRODUCTS

The Company currently does not have the resources to directly manufacture,
market or sell any of the Company's proposed products and the Company has no
current plans to acquire such resources.  The Company anticipates that it will,
in the future, enter into collaborative agreements with pharmaceutical and/or
biotechnology companies for the development of, clinical testing of, seeking of
regulatory approval for, manufacturing of, marketing of and commercialization of
certain of its proposed products.  The Company may in the future grant to its
collaborative partners rights to license and commercialize any products
developed under these collaborative agreements, and such rights would limit the
Company's flexibility in considering alternatives for the commercialization of
such products.  Under such agreements, the Company may rely on its respective
collaborative partners to conduct research efforts and clinical trials on,
obtain regulatory approvals for and manufacture, market and commercialize
certain of its products.  The Company expects that the amount and timing of
resources devoted to these activities generally will be controlled by each such
individual partner.  The inability of the Company to acquire such third party
manufacturing, distribution, marketing and selling arrangements for such
anticipated products would have a material adverse effect on the Company's
business.  There can be no assurance that the Company will be able to enter into
any arrangements for the manufacturing, marketing and selling of its products,
or that, if such arrangements are entered into, such future partners will be
successful in commercializing products or that the Company will derive any
revenues from such arrangements.


                                          7

<PAGE>

RISK OF PRODUCT LIABILITY; NO INSURANCE

Should the Company develop and market any products, the marketing of such
products, through third-party arrangements or otherwise, may expose the Company
to product liability claims.  The Company presently does not carry product
liability insurance.  Upon clinical testing or commercialization of the
Company's proposed products, certain of the licensors require that the Company
obtain product liability insurance.  There can be no assurance that the Company
will be able to obtain such insurance or, if obtained, that such insurance can
be acquired in sufficient amounts to protect the Company against such liability
or at a reasonable cost.  The Company is required to indemnify the Company's
licensors against any product liability claims incurred by them as a result of
the products developed by the Company.  None of the Company's licensors has
made, and are not expected to make, any representations as to the safety or
efficacy of the inventions covered by the licenses or as to any products which
may be made or used under rights granted therein or thereunder.

CONTROL BY EXISTING STOCKHOLDERS

Two principal stockholders of the Company beneficially own approximately 27% of
the outstanding shares of Common Stock.  Accordingly, such holders, if acting
together, may have the ability to exert significant influence over the election
of the Company's Board of Directors and other matters submitted to the Company's
stockholders for approval.  The voting power of these holders may discourage or
prevent any proposed takeover of the Company.

NO ASSURANCE OF IDENTIFICATION OF ADDITIONAL PROJECTS

The Company is engaged in the development and commercialization of biomedical
and pharmaceutical products and technologies.  From time to time, if the
Company's resources allow, the Company may explore the acquisition and
subsequent development and commercialization of additional biomedical and
pharmaceutical products and technologies.  However, there can be no assurance
that the Company will be able to identify any additional products or
technologies and, even if suitable products or technologies are identified, the
Company does not expect to have sufficient resources to pursue any such products
or technologies in the foreseeable future.

CERTAIN INTERLOCKING RELATIONSHIPS; POTENTIAL CONFLICTS OF INTEREST

Two of the four members of the Board of Directors and one of the officers of the
Company are full-time and/or part-time officers of Paramount Capital
Investments, LLC a New York-based merchant banking and venture capital firm
specializing in biotechnology companies ("Investments").  In the regular course
of its business, Investments identifies, evaluates and pursues investment
opportunities in biomedical and pharmaceutical products, technologies and
companies.  Generally, Delaware corporate law requires that any transactions
between the Company and any of its affiliates be on terms that, when taken as a
whole, are substantially as favorable to the Company as those then reasonably
obtainable from a person who is not an affiliate in an arms-length transaction.
Nevertheless, neither Investments nor any such directors are obligated pursuant
to any agreement or understanding with the Company to make any additional
products or technologies available to the Company, nor can there be any
assurance, and the Company does not expect and security holders should not
expect, that any biomedical or pharmaceutical product or technology identified
by Investments or any such directors in the future will be made available to the
Company.  In addition, certain of the officers and directors of the Company may
from time to time serve as officers or directors of other biopharmaceutical or
biotechnology companies.  There can be no assurance that such other companies
will not, in the future, have interests in conflict with those of the Company.

The Company has entered into several agreements with Investments pursuant to
which Investments provides financial advisory services to the Company.

RISKS ASSOCIATED WITH PENDING LITIGATION

In November 1996 and February 1997, related complaints alleging claims under the
Securities Exchange Act of 1934, as amended, and common law causes of action
were filed against the Company in the United States District Court for the
District of Delaware and the Delaware Chancery Court, respectively.  The parties
have reached a settlement with respect to such complaints, pursuant to which an
existing stockholder of the Company owning greater than five percent of the
Company's capital stock transferred to plaintiff an aggregate of 5,000 shares of
the Company's Common Stock.


                                          8

<PAGE>

POTENTIAL ADVERSE EFFECT OF REDEMPTION OF REDEEMABLE WARRANTS

The Redeemable Warrants are subject to redemption commencing December 14, 1996
by the Company under certain conditions.  Redemption of the Redeemable Warrants
could encourage holders to exercise the Redeemable Warrants and pay the exercise
price at a time when it may be disadvantageous for the holders to do so, to sell
the Redeemable Warrants at the current market price when they might otherwise
wish to hold the Redeemable Warrants, or to accept the redemption price, which
may be substantially less than the market value of the Redeemable Warrants at
the time of redemption.  The holders of the Redeemable Warrants will
automatically forfeit their rights to purchase the shares of Common Stock
issuable upon exercise of such Redeemable Warrants unless the Redeemable
Warrants are exercised before they are redeemed.  The holders of Redeemable
Warrants will not possess any rights as stockholders of the Company unless and
until such Redeemable Warrants are exercised.  See "Description of
Securities--Redeemable Warrants."

NO DIVIDENDS

The Company has not paid any cash dividends on its Common Stock since its
formation and does not anticipate paying any cash dividends in the foreseeable
future.  Management anticipates that all earnings and other resources of the
Company, if any, will be retained by the Company for investment in its business.

POSSIBLE DELISTING FROM NASDAQ AND MARKET ILLIQUIDITY

Although the Common Stock is quoted on Nasdaq, continued inclusion of such
securities on Nasdaq will require that (i) the Company maintain at least
$2,000,000 in total assets and $1,000,000 in capital and surplus, (ii) the
minimum bid price for the Common Stock be at least $1.00 per share, (iii) the
public float consist of at least 100,000 shares of Common Stock, valued in the
aggregate at more than $200,000, (iv) the Common Stock have at least two active
market makers and (v) the Common Stock be held by at least 300 holders.  If the
Company is unable to satisfy such maintenance requirements, the Company's
securities may be delisted from Nasdaq.  In such event, trading, if any, in the
Common Stock would thereafter be conducted in the over-the-counter market in the
"pink sheets" or the National Association of Securities Dealers' "Electronic
Bulletin Board."  Consequently, the liquidity of the Company's securities could
be materially impaired, not only in the number of securities that can be bought
and sold at a given price, but also through delays in the timing of transactions
and reduction in security analysts' and the media's coverage of the Company,
which could result in lower prices for the Company's securities than might
otherwise be attained and could also result in a larger spread between the bid
and asked prices for the Company's securities.

In addition, if the Common Stock is delisted from trading on Nasdaq and the
trading price of the Common Stock is less than $5.00 per share, trading in the
Common Stock would also be subject to the requirements of Rule 15g-9 promulgated
under the Exchange Act.  Under such rule, broker/dealers who recommended such
low-priced securities to persons other than established customers and accredited
investors must satisfy special sales practice requirements, including a
requirement that they make an individualized written suitability determination
for the purchaser and receive the purchaser's written consent prior to the
transaction.  The Securities Enforcement Remedies and Penny Stock Reform Act of
1990 also requires additional disclosure in connection with any trades involving
a stock defined as a penny stock (generally, according to recent regulations
adopted by the Commission, any equity security not traded on an exchange or
quoted on Nasdaq that has a market price of less than $5.00 per share, subject
to certain exceptions), including the delivery, prior to any penny stock
transaction, of a disclosure schedule explaining the penny stock market and the
risks associated therewith.  Such requirements could severely limit the market
liquidity of the Common Stock.  There can be no assurance that the Common Stock
will not be delisted or treated as penny stock.

LIQUIDITY OF INVESTMENT

The Company's securities are traded on the Nasdaq SmallCap Market, and the
Company's securities lack the liquidity of securities traded on the principal
trading markets.  Accordingly, an investor may be unable to promptly liquidate
an investment in the Common Stock.

POSSIBLE VOLATILITY OF STOCK PRICE

The market price of the Company's securities, like the stock prices of many
publicly traded biotechnology and smaller pharmaceutical companies, has been and
may continue to be highly volatile.


                                          9

<PAGE>

ENVIRONMENTAL REGULATION

In connection with its research and development activities, the Company is
subject to federal, state and local laws, rules, regulations and policies
governing the use, generation, manufacture, storage, air emission, effluent
discharge, handling and disposal of certain materials and wastes.  Although the
Company believes that it has complied with these laws and regulations in all
material respects and has not been required to take any action to correct any
noncompliance, there can be no assurance that the Company will not be required
to incur significant costs to comply with environmental and health and safety
regulations in the future.

POSSIBLE ADVERSE EFFECT OF SHARES ELIGIBLE FOR FUTURE SALE

Future sales by existing stockholders could adversely affect the prevailing
market price of the Company's Common Stock.  The outstanding shares of the
Company's Common Stock are all freely tradeable, subject to volume and other
restrictions imposed by Rule 144 under the Securities Act with respect to sales
by affiliates of the Company.  An 18-month restriction on transfer applicable to
the shares of Common Stock now owned or hereafter acquired by the Company's
officers, directors and certain stockholders expired on June 14, 1997.  Sales of
substantial amounts of Common Stock may have an adverse effect on the market
price of the Company's Common Stock.

In connection with the Company's initial public offering, the Company granted 
to Joseph Stevens & Company, L.P., the underwriter that managed the Company's 
initial public offering (the "Underwriter"), warrants to purchase from the 
Company 165,000 units, each consisting of one share of Common Stock and one 
redeemable warrant to purchase one share of Common Stock at an initial 
exercise price of $6.60 per unit.  Such warrants are exercisable during the 
four year period commenced December 13, 1996.  The redeemable warrants 
issuable upon exercise of these warrants have an exercise price of $6.05 per 
share.  As long as the warrants remain unexercised, the terms under which the 
Company could obtain additional capital may be adversely affected.  The 
Company granted to holders of the warrants issued to such Underwriter the 
right on two occasions (one at the expense of the Company) to file a 
registration statement under the Securities Act covering the securities 
underlying such warrants and the additional right to include such securities 
in any registration filed by the Company under the Securities Act.

No prediction can be made as to the effect, if any, that sales of Units,
Redeemable Warrants and/or Common Stock or the availability of such securities
for sale will have on the market prices prevailing from time to time for the
Units, the Redeemable Warrants and/or the Common Stock.  Nevertheless, the
possibility that substantial amounts of such securities may be sold in the
public market may adversely affect prevailing market prices for the Company's
equity securities and could impair the Company's ability to raise capital in the
future through the sale of equity securities.

ANTITAKEOVER EFFECTS OF PROVISIONS OF THE CERTIFICATE OF INCORPORATION AND
DELAWARE LAW

    Atlantic's Certificate of Incorporation authorizes the issuance of shares
of "blank check" Preferred Stock.  The Board of Directors has the authority to
issue the Preferred Stock in one or more series and to fix the relative rights,
preferences and privileges and restrictions thereof, including dividend rights,
dividend rates, conversion rights, voting rights, terms of redemption,
redemption prices, liquidation preferences and the number of shares constituting
any series or the designation of such series.  The issuance of Preferred Stock
may have the effect of delaying, deferring or preventing a change in control of
the Company without further action by the stockholders of the Company.  The
issuance of Preferred Stock with voting and conversion rights may adversely
affect the voting power of the holders of the Common Stock, including the loss
of voting control to others.

    The Company is subject to Section 203 of the Delaware General Corporation
Law which, subject to certain exceptions, prohibits a Delaware corporation from
engaging in any business combination with any interested stockholder for a
period of three years following the date that such stockholder became an
interested stockholder.  In general, Section 203 defines an interested
stockholder as any entity or person beneficially owning 15% or more of the
outstanding voting stock of the corporation and any entity or person affiliated
with or controlling or controlled by such entity or person.  The foregoing
provisions could have the effect of discouraging others from making tender
offers for the Company's shares and, as a consequence, they also may inhibit
fluctuations in the market price of the Company's shares that could result from
actual or rumored takeover attempts.  Such provisions also may have the effect
of preventing changes in the management of the Company.


                                          10
<PAGE>

                              RECENT DEVELOPMENTS

    On May 22, 1997 and August 7, 1997, the Company completed private
placements (the "Private Placement") of an aggregate of 123.72 units, each unit
consisting of 10,000 shares of the Company's Series A Convertible Preferred
Stock (the "Series A Preferred"), for gross proceeds of approximately
$12,372,000.  Paramount Capital, Inc., a New York-based merchant banking and
venture capital firm specializing in biotechnology companies ("Paramount" or the
"Placement Agent"), acted as placement agent for the Private Placement.
Lindsay A. Rosenwald, M.D., a principal stockholder of the Company, is the
President and sole stockholder of the Placement Agent and of VentureTek, L.P., a
principal stockholder of the Company.

    In connection with the Private Placement, the Company paid to the Placement
Agent compensation in the form of cash commissions and a non-accountable expense
allowance equal to nine percent and four percent, respectively, of the gross
proceeds received by the Company from the sale of the units.  In addition, the
Company agreed to sell to Paramount or its designees, for nominal consideration,
warrants (the "Placement Warrants") to purchase an aggregate of 123,720 shares
of Series A Preferred.  For a description of the terms of the Series A Preferred
issued in the Private Placement and of the Placement Warrants, see "Description
of Securities--Preferred Stock--Series A Convertible Preferred Stock" and
"Description of Securities--Placement Warrants."

    Also in connection with the Private Placement, the Company and the
Placement Agent agreed to enter into a financial advisory agreement (the
"Agreement") pursuant to which the Placement Agent will act as the Company's
non-exclusive financial advisor.  Such engagement will provide that the
Placement Agent receive (i) a monthly retainer of $4,000 commencing on the first
of the month following the date of the Agreement (with a minimum engagement of
24 months), (ii) out-of-pocket expenses incurred in connection with services
performed under the Agreement and (iii) standard success fees in the event the
Placement Agent assists the Company in connection with certain financing and
strategic transactions.


                                          11

<PAGE>

                           SELLING SECURITYHOLDERS

    The following table sets forth certain information, as of the date hereof,
with respect to the number of shares of Common Stock beneficially owned by each
of the Selling Securityholders and as adjusted to give effect to the sale of the
Shares offered hereby.  Beneficial ownership of the shares offered hereby by
such Selling Securityholders will depend on the number of shares sold by each
Selling Securityholder in this offering.  The Shares are being registered to
permit public secondary trading of the Shares, and the Selling Securityholders
may offer the Shares for resale from time to time.  Except as indicated in this
Prospectus, none of the Selling Securityholders has had a material relationship
with the Company within the past three years other than as a result of the
ownership of the Shares or other securities of the Company.  See "Plan of
Distribution."

    The Shares offered by this Prospectus may be offered from time to time by
the Selling Securityholders named below:

<TABLE>
<CAPTION>

                                            Number of Shares
                                                Owned                                      Ownership
                                          Prior to Offering(1)      Number of           after Offering(1)
                                          --------------------       Shares             -----------------
  Name and Address of                Number of                        Being           Number of
  Selling Securityholder              Shares           Percent       Offered            Shares     Percent
  ----------------------             ---------         -------      ---------         ---------    -------
<S>                                  <C>               <C>          <C>               <C>          <C>
Dreyfus Growth and Value
  Funds, Inc., a Maryland
  corporation,--Dreyfus
  Aggressive Growth Fund(2)
    200 Park Avenue
    New York, NY  10166 . . .         140,000           4.64%        140,000              0          0%

Premier Strategic Growth
  Fund(2), a Massachusetts
  Business Trust (2)
    200 Park Avenue
    New York, NY  10166 . . .         110,000           3.65%        110,000              0          0%
                                                                     -------
         TOTAL. . . . . . . .                                        250,000
                                                                     -------
                                                                     -------
- ---------------------------

</TABLE>

(1) Percentage of beneficial ownership is calculated assuming 3,016,920 shares
    of Common Stock were outstanding as of June 30, 1997.  Beneficial ownership
    is determined in accordance with the rules of the Securities and Exchange
    Commission and generally includes voting or investment power with respect
    to securities.  Shares of Common Stock subject to options or warrants
    currently exercisable or convertible, or exercisable or convertible within
    60 days of June 30, 1997, are deemed outstanding for computing the
    percentage of the person holding such option or warrant but are not deemed
    outstanding for computing the percentage of any other person.  Except as
    indicated in the footnotes to this table and pursuant to applicable
    community property laws, the persons named in the table have sole voting
    and investment power with respect to all shares of Common Stock
    beneficially owned.
(2) The Dreyfus Corporation serves as the investment advisor for each of
    Dreyfus Growth and Value Funds, Inc., a Maryland corporation,--Dreyfus
    Aggressive Growth Fund and Premier Strategic Growth Fund, a Massachusetts
    Business Trust, and as such may be considered the beneficial owner of the
    shares of Common Stock held by such funds.


                                          12

<PAGE>

                             PLAN OF DISTRIBUTION

    The Shares offered by the Selling Securityholders are not being
underwritten.  The Company will receive no proceeds from the sale of the Shares.
The Shares offered hereby may be sold by the Selling Securityholders from time
to time in transactions (which may include block transactions ) in the
over-the-counter market, in negotiated transactions, or a combination of such
methods of sale, at fixed prices that may be changed, at market prices
prevailing at the time of sale, or at negotiated prices.  The Selling
Securityholders may effect such transactions by selling the Shares directly to
purchasers or through broker-dealers that may act as agents or principals.  Such
broker-dealers may receive compensation in the form of discounts, concessions or
commissions from the Selling Securityholders and/or the purchasers of the Shares
for whom such broker-dealers may act as agents or to whom they sell as
principals, or both (which compensation as to a particular broker-dealer might
be in excess of customary commissions).

    The Dreyfus Corporation serves as the investment advisor for each of
Dreyfus Growth and Value Funds, Inc., a Maryland corporation,--Dreyfus
Aggressive Growth Fund ("Value Fund") and Premier Strategic Growth Fund, a
Massachusetts business trust ("Growth Fund"), and as such may be considered the
beneficial owner of the shares of Common Stock held by such funds.  Value Fund
and Growth Fund together own an aggregate of eight percent of the Company's
capital stock, and therefore either fund or The Dreyfus Corporation may be
deemed affiliates of the Company.  Other than the foregoing, there are no
material relationships between any of the Selling Securityholders and the
Company or any of its predecessors or affiliates.

    The Selling Securityholders and any broker-dealers that act in connection
with the sale of the Shares as principals may be deemed to be "underwriters"
within the meaning of Section 2(11) of the Securities Act and any commission
received by them and any profit on the resale of such securities as principals
might be deemed to be underwriting discounts and commissions under the
Securities Act.  The Selling Securityholders may agree to indemnify any agent,
dealer or broker-dealer that participates in transactions involving sales of
such securities against certain liabilities, including liabilities arising under
the Securities Act.  The Company will not receive any proceeds from the sales of
the Shares.  Sales of the Shares by the Selling Securityholders, or even the
potential of such sales, would likely have an adverse effect on the market price
of the Company's outstanding Units, Common Stock and Redeemable Warrants.

    At the time a particular offer of securities is made by or on behalf of the
Selling Securityholder, to the extent required, a prospectus will be distributed
which will set forth the number of securities being offered and the terms of the
offering, including the name or names of any underwriters, dealers or agents, if
any, the purchase price paid by any underwriter for securities purchased from
the Selling Securityholder and any discounts, commissions or concessions allowed
or reallowed or paid to dealers.

    In order to comply with the securities laws of certain states, if
applicable, the Shares will be sold in such jurisdictions only through
registered or licensed brokers or dealers.  In addition, in certain states the
Shares may not be sold unless they have been registered or qualified for sale in
the applicable state or an exemption from the registration or qualification
requirement is available and is complied with.

    Under applicable rules and regulations under the Exchange Act, any person
engaged in the distribution of the Shares may not simultaneously engage in
market making activities with respect to the securities of the Company for a
period of two business days prior to the commencement of such distribution.  In
addition and without limiting the foregoing, each Selling Securityholder will be
subject to applicable provisions of the Exchange Act and the rules and
regulations thereunder, including, without limitation, Rules 10b-6 and 10b-7,
which provisions may limit the timing of purchases and sales of shares of the
Shares by the Selling Securityholders.

    The Shares were originally issued to the Selling Securityholders pursuant
to an exemption from the registration requirements of the Securities Act
provided by Section 4(2) thereof.  The Company agreed to register the Shares
under the Securities Act and to indemnify and hold such Selling Securityholders
harmless against certain liabilities under the Securities Act that could arise
in connection with the sale by such Selling Securityholders of the Shares.  The
Company has agreed to pay all reasonable fees and expenses incident to the
preparation and filing of this Prospectus and the Registration Statement on Form
S-3 of which it is a part.


                                          13
<PAGE>

                           DESCRIPTION OF SECURITIES

    The authorized capital stock of the Company consists of 80,000,000 shares
of Common Stock and 50,000,000 shares of Preferred Stock.

UNITS

    As of June 30, 1997, there were 1,872,750 Units outstanding.  Each Unit
consists of one share of Common Stock and one Redeemable Warrant.  The
securities included in each Unit trade separately.

COMMON STOCK

    As of June 30, 1997, there were 3,016,920 shares of Common Stock
outstanding, which include the shares of Common Stock composing the Units.  In
addition, as of June 30, 1997, there were outstanding options to purchase
699,155 shares of Common Stock at exercise prices ranging from $0.001 to $7.50
per share.  Such options expire on various dates through August 15, 2006.

    The holders of Common Stock are entitled to one vote per share on all
matters to be voted upon by the stockholders.  Subject to preferences that may
be applicable to any outstanding Preferred Stock, the holders of Common Stock
are entitled to receive ratably such dividends, if any, as may be declared from
time to time by the Company's Board of Directors out of funds legally available
therefor.  In the event of the liquidation, dissolution or winding up of the
Company, the holders of Common Stock are entitled to share ratably in all assets
remaining after payment of liabilities, subject to prior distribution rights of
Preferred Stock, if any, then outstanding.  The Common Stock has no preemptive
or conversion rights or other subscription rights.  There are no redemption or
sinking fund provisions applicable to the Common Stock.  All outstanding shares
of Common Stock are fully paid and nonassessable, and the shares of Common Stock
to be issued upon completion of the Offering will be fully paid and
nonassessable.

PREFERRED STOCK

    The Company's Certificate of Incorporation authorizes 50,000,000 shares of
Preferred Stock.  The Company's Board of Directors has the authority to issue
Preferred Stock in one or more series and to fix the relative rights,
preferences and privileges and restrictions thereof, including dividend rights,
dividend rates, conversion rights, voting rights, terms of redemption,
redemption prices, liquidation preferences and the number of shares constituting
any series or the designation of such series.  The issuance of Preferred Stock
may have the effect of delaying, deferring or preventing a change in control of
the Company without further action by the stockholders of the Company.  The
issuance of Preferred Stock with voting and conversion rights may adversely
affect the voting power of the holders of the Common Stock, including the loss
of voting control to others.  There are no shares of Preferred Stock currently
issued and outstanding.  See "Risk Factors--Need for Additional Financing;
Issuance of Securities by the Operating Companies; Future Dilution" and
"--Antitakeover Effects of Provisions of the Certificate of Incorporation and
Delaware Law."

    SERIES A CONVERTIBLE PREFERRED STOCK

    The Company has designated 1,375,000 shares of Preferred Stock as "Series A
Convertible Preferred Stock" (the "Series A Preferred").  As of August 15, 1997,
there were outstanding 1,237,200 shares of Series A Preferred and warrants to
purchase 123,720 shares of Series A Preferred.  The following is a brief summary
of the rights, preferences and privileges of the Series A Preferred.  A complete
description of the rights, preferences and privileges of the Series A Preferred
is set forth in the Company's Certificate of Designation with respect thereto.

         DIVIDENDS.  Holders of Series A Preferred will be entitled to receive
dividends as, when and if declared by the Board of Directors.  Commencing on
August 7, 1998, holders of Series A Preferred will be entitled to a cumulative
payment-in-kind dividend (the "PIK Dividend") payable in additional shares of
Series A Preferred at the rate of 10% per annum of the Dividend Base Amount,
payable semi-annually, unless their shares of Series A Preferred have previously
been converted into Common Stock.  The Dividend Base Amount shall be $13.00 plus
accrued and unpaid dividends (subject to antidilution adjustment).  The Company
shall not declare any dividend or distribution on any other capital stock of the
Company unless and until a special dividend or distribution of $13.00 per share
(subject to appropriate adjustment to reflect any stock split, combination,
reclassification or reorganization of the Series A Preferred) has been declared
and paid on the Series A Preferred.  No dividend or distribution, as the case
may be, shall be declared or paid on any junior stock unless the same dividend
is paid to holders of Series A


                                          14

<PAGE>

Preferred.  The Company does not intend to pay cash dividends on the Series A
Preferred or the underlying Common Stock for the foreseeable future.

         CONVERSION.  Each share of Series A Preferred is convertible at the
option of the holder thereof, at any time after the issuance thereof, into
shares of Common Stock initially at a conversion price equal to the lesser of
(i) $5.625 and (ii) 85% of the average closing bid price of the Common Stock on
Nasdaq SmallCap for the 30 consecutive trading days immediately preceding
(a) May 22, 1997 or (b) August 7, 1997, whichever is lowest.  The conversion
price is subject to adjustment upon the occurrence of certain events.  Unless
converted earlier, the Company may, at any time on or after August 7, 1998, at
its option, cause the conversion of the Series A Preferred, in whole or in part,
on a PRO RATA basis, into shares of Common Stock at the conversion price in
effect at that time if the closing bid price of the Common Stock has exceeded
200% of the then applicable conversion price for at least 20 trading days in any
30 consecutive trading day period ending three days prior to the date of notice
of conversion.

         LIQUIDATION PREFERENCE.  Upon (i) a liquidation, dissolution or
winding up of the Company, whether voluntary or involuntary, (ii) a sale or
other disposition of all or substantially all of the assets of the Company or
(iii) any consolidation, merger, combination, reorganization or other
transaction in which the Company is not the surviving entity or in which the
shares of Common Stock constituting in excess of 50% of the voting power of the
Company are exchanged for or changed into other stock or securities, cash and/or
any other property, after payment or provision for payment of the debts and
other liabilities of the Company, the holders of the Series A Preferred then
outstanding will first be entitled to receive, PRO RATA (on the basis of the
number of shares of the Series A Preferred then outstanding), and in preference
to the holders of the Common Stock and any capital stock of the Company, an
amount per share equal to $13.00 plus accrued but unpaid dividends, if any,
which in certain circumstances may be paid in securities of another corporation.

         VOTING RIGHTS.  The holders of shares of Series A Preferred have the
right at all meetings of stockholders of the Company to that number of votes
equal to the number of shares of Common Stock issuable upon conversion of the
Series A Preferred at the record date for determination of the stockholders
entitled to vote on such matters or, if no such record date is established, at
the date such vote is taken.  So long as at least 50% of the shares of Series A
Preferred remain outstanding, the affirmative vote or consent of the holders of
66.67% of the shares of Series A Preferred shall be necessary to permit, effect
or validate any one or more of the following:  (i) the amendment of the
Certificate of Incorporation or Bylaws of the Company if it adversely affects
the relative rights of the holders of the Series A Preferred, (ii) the
declaration or payment of a dividend on any securities of the Company other than
the Series A Preferred or the authorization of the repurchase of any securities
of the Company, (iii) the issuance of any security ranking senior to or on a
parity with the Series A Preferred with respect to (A) a liquidation event,
(B) the payment of dividends or (C) voting rights (except class voting rights
required by law), (iv) any liquidation, dissolution or sale of substantially all
of the assets of the Company, (v) the incorporation of any subsidiary company
and (vi) the issuance of any debt securities or incurrence of indebtedness for
borrowed money in excess of $1,000,000, PROVIDED, HOWEVER, that any issuance of
debt securities or incurrence of indebtedness for borrowed money in excess of
$500,000 shall be approved by a supermajority of the Board of Directors of the
Company.

REDEEMABLE WARRANTS

    The Redeemable Warrants were issued in the Company's initial public
offering pursuant to a warrant agreement (the "Redeemable Warrant Agreement")
among Joseph Stevens & Company, L.P. (the "Underwriter"), the Company and
Continental Stock Transfer & Trust Company (the "Warrant Agent"), and are
evidenced by warrant certificates in registered form.  The following summary is
qualified in its entirety by the text of the Redeemable Warrant Agreement, a
copy of which has been filed as an exhibit to the Registration Statement.

    Each Redeemable Warrant entitles the registered holder thereof to purchase
one share of Common Stock at a price of $5.50 per share, subject to adjustment,
commencing on the date of issuance.  The Redeemable Warrants expire on December
13, 2000 (the "Expiration Date").  As of December 14, 1996 the Redeemable
Warrants are subject to redemption by the Company at a redemption price of $0.05
per Redeemable Warrant on 30 days' prior written notice, provided that the
average closing bid price (or last sales price) of the Common Stock as reported
on Nasdaq (or on such exchange on which the Common Stock is then traded) equals
or exceeds $8.25 per share, subject to adjustment, for any 20 trading days
within a period of 30 consecutive trading days ending on the fifth trading day
prior to the date of notice of redemption.  The holder of a Redeemable Warrant
will lose his right to purchase if such right is not exercised prior to
redemption by the Company on the date for redemption specified in the Company's
notice of redemption or any later date specified in a subsequent notice.  Notice
of redemption by the Company shall be given by first class mail to the holders
of the Redeemable Warrants at their addresses set forth in the Company's
records.


                                          15

<PAGE>

    The exercise price of the Redeemable Warrants and the number and kind of
shares of Common Stock or other securities and property to be obtained upon
exercise of the Redeemable Warrants are subject to adjustment in certain
circumstances including a stock split of, or stock division, combination or
recapitalization of, the Common Stock.  Additionally, an adjustment would be
made upon the consolidation of the Company with or the merger of the Company
with or into another corporation (other than a consolidation or merger which
does not result in any reclassification or change of the outstanding Common
Stock) so as to enable Redeemable Warrant holders to purchase the kind and
number of shares of stock or other securities or property (including cash)
receivable in such event by a holder of the number of shares of Common Stock
that might otherwise have been purchased upon exercise of such Redeemable
Warrant.  No adjustment for cash dividends, if any, will be made upon exercise
of the Redeemable Warrants.

    The exercise price of the Redeemable Warrants bears no relation to any
objective criteria of value and should not be regarded as an indication of the
future market price of the securities offered hereby.  The Redeemable Warrants
do not confer upon the holder any voting or any other rights of a stockholder of
the Company.  Upon notice to the Redeemable Warrant holders, the Company has the
right to reduce the exercise price or extend the expiration date of the
Redeemable Warrants.

    The Redeemable Warrants may be exercised upon surrender of the Redeemable
Warrant certificate on or prior to the expiration date (or earlier redemption
date) of such Redeemable Warrant at the offices of the Warrant Agent, with the
form of "Election to Purchase" on the reverse side of the Redeemable Warrant
certificate completed and executed as indicated, accompanied by payment of the
full exercise price (by cashier's or certified check payable to the order of the
Warrant Agent) for the number of Redeemable Warrants being exercised.  The
Redeemable Warrants will become void and of no value upon the Expiration Date.
A holder may sell the Redeemable Warrants instead of exercising them.  There can
be no assurance, however, that a market for the Redeemable Warrants will
continue.  If a prospectus covering the shares of Common Stock issuable upon the
exercise of Redeemable Warrants is not kept effective and current or if such
shares are not qualified for sale in certain states, holders of Redeemable
Warrants desiring to exercise the Redeemable Warrants will have no choice but
either to sell such Redeemable Warrants or let them expire.  See "Risk
Factors--Securities Law Restrictions on the Exercise of Redeemable Warrants."

    The Redeemable Warrant Agreement provides that it may be amended at any
time with the written consent of registered holders representing at least
66 2/3% of the Redeemable Warrants then outstanding.

UNDERWRITER'S WARRANTS

    In connection with the Company's initial public offering, the Company sold
to the Underwriter, for nominal consideration, Underwriter's Warrants to
purchase from the Company 165,000 Units.  The Underwriter's Warrants are
initially exercisable at a price equal to $6.60 and may be exercised at any time
during the four year period commenced December 14, 1996.  The shares of Common
Stock and Redeemable Warrants issuable upon exercise of the Underwriter's
Warrants are identical to those offered to the public pursuant to the Unit
Offering, except that the Redeemable Warrants issuable upon exercise of the
Underwriter's Warrants have an exercise price of $6.05 per share and such
Redeemable Warrants have not been approved for quotation on Nasdaq.  The
Underwriter's Warrants contain anti-dilution provisions providing for adjustment
of the number of warrants and exercise price under certain circumstances.  The
Underwriter's Warrants grant to the holders thereof certain rights of
registration for the securities issuable upon exercise of the Underwriter's
Warrants.

PLACEMENT WARRANTS

    In connection with the Private Placement, the Company sold to the Placement
Agent, for nominal consideration, Placement Warrants to purchase from the
Company 123,720 shares of Series A Preferred.  The Placement Warrants are
initially exercisable at a price equal to $11.00 per share and may be exercised
at any time during the 10-year period commencing February 7, 1998.  The rights,
preferences and privileges of the shares of Series A Preferred issuable upon
exercise of the Placement Warrants are identical to those offered to the
participants in the Private Placement.  The Placement Warrants contain
anti-dilution provisions providing for adjustment of the number of warrants and
exercise price under certain circumstances.  The Placement Warrants grant to the
holders thereof certain rights of registration for the securities issuable upon
exercise of the Placement Warrants.  See "--Registration Rights."


                                          16

<PAGE>

REGISTRATION RIGHTS

    In connection with the Private Placement, the Company has agreed to use its
best efforts to (i) on or prior to September 8, 1997, file with the Commission a
registration statement with respect to the Common Stock issuable upon conversion
of the Series A Preferred, including the Series A Preferred issuable upon
exercise of the Placement Warrants, and (ii) cause such registration statement
to remain effective until the date the holders of the Series A Preferred have
completed the distribution of such securities or until such earlier time as such
shares are no longer, by reason of Rule 144(k) promulgated under the Securities
Act, required to be registered for the sale thereof by such holders.  If
requested by the Placement Agent, and if practicable in accordance with
applicable laws, the registration statement will cover the direct sale of the
Common Stock registered thereon to the holders of such securities.

    In addition to the Series A Preferred issued in the Private Placement, the
Company may include in such registration statement up to an additional 788,951
shares of Common Stock covered by piggyback registration rights granted by the
Company to Lindsay A. Rosenwald, M.D., a principal stockholder of the Company
and the President and sole stockholder of the Placement Agent and of VentureTek,
L.P., a principal stockholder of the Company.

ANTITAKEOVER EFFECTS OF PROVISIONS OF DELAWARE LAW

    The Company is subject to Section 203 of the Delaware General Corporation
Law ("Section 203"), which, subject to certain exceptions, prohibits a Delaware
corporation from engaging in any business combination with any interested
stockholder for a period of three years following the date that such stockholder
became an interested stockholder, unless: (i) prior to such date, the board of
directors of the corporation approved either the business combination or the
transaction that resulted in the stockholder becoming an interested stockholder;
(ii) upon consummation of the transaction that resulted in the stockholder
becoming an interested stockholder, the interested stockholder owned at least
85% of the voting stock of the corporation outstanding at the time the
transaction commenced, excluding for purposes of determining the number of
shares outstanding those shares owned (x) by persons who are directors and also
officers and (y) by employee stock plans in which employee participants do not
have the right to determine confidentially whether shares held subject to the
plan will be tendered in a tender or exchange offer; or (iii) on or subsequent
to such date, the business combination is approved by the board of directors and
authorized at an annual or special meeting of stockholders, and not by written
consent, by the affirmative vote of at least 66 2/3% of the outstanding voting
stock that is not owned by the interested stockholder.

    Section 203 defines business combination to include: (i) any merger or
consolidation involving the corporation and the interested stockholder; (ii) any
sale, transfer, pledge or other disposition of 10% or more of the assets of the
corporation involving the interested stockholder; (iii) subject to certain
exceptions, any transaction that results in the issuance or transfer by the
corporation of any stock of the corporation to the interested stockholder; (iv)
any transaction involving the corporation that has the effect of increasing the
proportionate share of the stock of any class or series of the corporation
beneficially owned by the interested stockholder; or (v) the receipt by the
interested stockholder of the benefit of any loans, advances, guarantees,
pledges or other financial benefits provided by or through the corporation.  In
general, Section 203 defines an interested stockholder as any entity or person
beneficially owning 15% or more of the outstanding voting stock of the
corporation and any entity or person affiliated with or controlling or
controlled by such entity or person.

TRANSFER AGENT, REGISTRAR AND WARRANT AGENT

    The Transfer Agent and Registrar for the Shares is Continental Stock
Transfer & Trust Company ("CST&T"), 2 Broadway, New York, New York 10004.  CST&T
can be reached at (212) 509-4000.  CST&T is also the Warrant Agent for the
Redeemable Warrants.


                                          17

<PAGE>

                                 LEGAL MATTERS

    Certain legal matters with respect to the validity of the Shares offered
hereby are being passed upon for the Company by Brobeck, Phleger & Harrison LLP,
Palo Alto, California.

                                    EXPERTS

    The consolidated financial statements of the Company appearing in the 
Company's Annual Report on Form 10-KSB for the year ended December 31, 1996, 
for each of the years in the three-year period ended December 31, 1996, and 
for the period from July 13, 1993 (inception) to December 31, 1996, have been 
incorporated by reference herein in reliance upon the report of KPMG Peat 
Marwick LLP ("KPMG"), independent certified public accountants, and upon the 
authority of such firm as experts in accounting and auditing.  The report of 
KPMG covering the consolidated financial statements referred to above 
contains an explanatory paragraph that states that the Company has suffered 
recurring losses from operations and has limited capital resources which 
raise substantial doubt about its ability to continue as a going concern.  
The consolidated financial statements do not include any adjustments that 
might result from the outcome of that uncertainty.

                                          18

<PAGE>

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    No dealer, salesperson or any other person has been authorized to give any
information or to make any representations other than those contained in this
Prospectus, and, if given or made, such information or representations must not
be relied upon as having been authorized by the Company. Neither the delivery of
this Prospectus nor any sale made hereunder shall, under any circumstances,
create any implication that there has been no change in the affairs of the
Company or that the information contained herein is correct as of any time
subsequent to the date hereof. This Prospectus does not constitute an offer to
sell or a solicitation for an offer to buy any securities offered hereby by
anyone in any jurisdiction in which such offer or solicitation is not authorized
or in which the person making such offer or solicitation is not qualified to do
so or to anyone to whom it is unlawful to make such offer or solicitation.

                           -------------------------
                               TABLE OF CONTENTS
                           -------------------------
                                                                            PAGE

Available Information . . . . . . . . . . . . . . . . . . . . . . . . . .
Information Incorporated by Reference . . . . . . . . . . . . . . . . . .
Risk Factors  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Recent Developments . . . . . . . . . . . . . . . . . . . . . . . . . . .
Selling Securityholders . . . . . . . . . . . . . . . . . . . . . . . . .
Plan of Distribution. . . . . . . . . . . . . . . . . . . . . . . . . . .
Description of Securities . . . . . . . . . . . . . . . . . . . . . . . .
Legal Matters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Experts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

                                ------------


    Until           , 1997 (25 days after the date of this Prospectus), all
dealers effecting transactions in the registered securities offered hereby,
whether or not participating in this distribution, may be required to deliver a
Prospectus. This is in addition to the obligation of dealers to deliver a
Prospectus when acting as underwriters and with respect to their unsold
allotments or subscriptions.

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                            ATLANTIC PHARMACEUTICALS, INC.


                                    250,000 SHARES
                                     COMMON STOCK


                                 --------------------
                                      PROSPECTUS
                                 --------------------


                                  August ____, 1997


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- --------------------------------------------------------------------------------

<PAGE>

                                       PART II

                        INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

    All expenses incurred in connection with the issuance and distribution of
the securities being registered will be paid by the Registrant.  The following
is an itemized statement of these expenses. All amounts are estimates except the
Securities and Exchange Commission registration fee and the Nasdaq listing fee.

    SEC registration fee . . . . . . . . . . . . . . . . .      $      531
    Nasdaq listing fee . . . . . . . . . . . . . . . . . .           5,000
    Printing and Engraving . . . . . . . . . . . . . . . .          10,000
    Legal fees and expenses of the Registrant. . . . . . .          30,000
    Accounting fees and expenses . . . . . . . . . . . . .           5,000
    Miscellaneous. . . . . . . . . . . . . . . . . . . . .           4,469
                                                                    ------
                Total. . . . . . . . . . . . . . . . . . .      $   55,000
                                                                    ------
                                                                    ------

ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

    Section 145 of the Delaware General Corporation Law ("Section 145")
authorizes a court to award or a corporation's Board of Directors to grant
indemnification to directors and officers in terms sufficiently broad to permit
such indemnification under certain circumstances for liabilities (including
reimbursement for expenses incurred) arising under the Securities Act.  Article
Tenth of the Registrant's Certificate of Incorporation provides for mandatory
indemnification by the Registrant of all persons the Registrant may indemnify
under Section 145 to the maximum extent permitted by the Delaware General
Corporation Law.  Article Ninth of the Registrant's Certificate of Incorporation
provides that the liability of its directors is eliminated to the fullest extent
permitted by the Delaware General Corporation Law.  These provisions in the
Certificate of Incorporation do not eliminate the directors' fiduciary duty, and
in appropriate circumstances equitable remedies such as injunctive or other
forms of non-monetary relief will remain available under Delaware law.  In
addition, each director will continue to be subject to liability for breach of
the director's duty of loyalty to the Registrant for acts or omissions not in
good faith or involving intentional misconduct, for knowing violations of law,
for actions leading to improper personal benefit to the director, and for
payment of dividends or approval of stock repurchases or redemptions that are
unlawful under Delaware law.  The provision also does not affect a director's
responsibilities under any other law, such as the federal securities laws or
state or federal environmental laws.  Reference is made to Articles Ninth and
Tenth of the Registrant's Certificate of Incorporation and Article VII of the
Registrant's Bylaws, indemnifying the Registrant's directors and officers
against certain liabilities, and Section 1.10 of the Investors' Rights Agreement
dated July 1995, among the Registrant, Dr. Lindsay A. Rosenwald and VentureTek,
L.P., indemnifying certain of the Registrant's stockholders against certain
liabilities.  The Registrant has obtained liability insurance for its directors
and officers.  At the Registrant's 1997 Annual Meeting of Stockholders, the
stockholders of the Registrant approved a form of indemnification agreement to
be entered into by and between the Registrant and its directors and officers,
which agreements grant indemnification under certain circumstances to such
officers and directors for liabilities (including reimbursement for expenses
incurred) arising out of their duties as officers and directors of the
Registrant.

    In addition, the Registrant has entered into financial advisory and other
agreements with Paramount Capital, Inc. ("Paramount"), a merchant banking and
venture capital firm specializing in biotechnology companies that is wholly
owned by a greater than five percent stockholder of the Registrant, pursuant to
which the Registrant will indemnify Paramount and its affiliates against
liabilities (including reimbursement for expenses incurred) arising out of its
provision of services to the Registrant.


                                         II-1
<PAGE>


ITEM 16.  EXHIBITS

Exhibit No.    Description

3.1 (1)        Certificate of Incorporation of the Registrant,
               as amended to date.
3.2 (1)        Bylaws of the Registrant, as amended to date.
3.3 (5)        Certificate of Designations of Series A
               Convertible Preferred Stock.
3.4            Certificate of Increase of Series A Convertible
               Preferred Stock.
4.2 (1)        Form of Unit certificate.
4.3 (1)        Specimen Common Stock certificate.
4.4 (1)        Form of Redeemable Warrant certificate.
4.5 (1)        Form of Redeemable Warrant Agreement, by and
               between the Registrant and Continental Stock
               Transfer & Trust Company.
4.6 (1)        Form of Underwriter's Warrant certificate.
4.7 (1)        Form of Underwriter's Warrant Agreement by and
               between the Registrant and Joseph Stevens &
               Company, L.P
4.8 (1)        Form of Subscription Agreement, by and between
               the Registrant and the Selling Securityholders.
4.9 (1)        Form of Bridge Note.
4.10 (1)       Form of Bridge Warrant.
4.11 (2)       Investors' Rights Agreement by and among the
               Registrant, Dreyfus Growth and Value Funds,
               Inc. and Premier Strategic Growth Fund.
4.12 (2)       Common Stock Purchase Agreement by and among
               the Registrant, Dreyfus Growth and Value Funds,
               Inc. and Premier Strategic Growth Fund
5.1            Opinion of Brobeck, Phleger & Harrison LLP.
10.1 (1)       The Registrant's 1995 Stock Option Plan.
10.2 (1)       Employment Agreement, dated July 7, 1995,
               between the Registrant and Jon D. Lindjord.
10.3 (1)       Employment Agreement, dated September 21, 1995,
               between the Registrant and Dr. Stephen R.
               Miller.
10.4 (1)       Employment Agreement, dated September 21, 1995,
               between the Registrant and Margaret A. Schalk.
10.5 (1)       Letter Agreement, dated August 31, 1995,
               between the Registrant and Dr. H. Lawrence
               Shaw.
10.6 (1)       Consulting Agreement, dated January 1, 1994,
               between the Registrant and John K.A.
               Prendergast.
10.7 (1)       (Reserved)
10.8 (1)       Investors' Rights Agreement, dated July, 1995,
               between the Registrant, Dr. Lindsay A.
               Rosenwald and VentureTek, L.P.
10.9 (1)       License and Assignment Agreement, dated March
               25, 1994, between Optex Ophthalmologics, Inc.,
               certain inventors and NeoMedix Corporation, as
               amended.
10.10 (1)      License Agreement, dated May 5, 1994, between
               Gemini Gene Therapies, Inc. and The Cleveland
               Clinic Foundation.
10.11 (1) +    License Agreement, dated June 16, 1994, between
               Channel Therapeutics, Inc., the University of
               Pennsylvania and certain inventors, as amended.
10.12 (1) +    License Agreement, dated March 28, 1994,
               between Channel Therapeutics, Inc. and Dr.
               Sumner Burstein.
10.13 (1)      Form of Financial Advisory and Consulting
               Agreement by and between the Registrant and
               Joseph Stevens & Company, L.P.
10.14 (1)      Employment Agreement, dated November 3, 1995,
               between the Registrant and Shimshon Mizrachi.


                                         II-2

<PAGE>

10.15 (3)      Financial agreement between the Registrant and
               Paramount dated September 4, 1996 (effective
               date of April 15, 1996).
10.16 (3)      Financial agreement between the Registrant,
               Paramount and UI USA dated June 23, 1996.
10.17 (3)      Consultancy agreement between the Registrant
               and Dr. Yuichi Iwaki dated July 31, 1996.
10.18 (3)      1995 Stock Option Plan, as amended.
10.19 (3)      Warrant to purchase 25,000 shares of Common
               Stock issued to Paramount Capital, Inc.
10.20 (3)      Warrant to purchase 25,000 shares of Common
               Stock issued to Paramount Capital, Inc.
10.21 (3)      Warrant to purchase 12,500 shares of Common
               Stock issued to Paramount Capital, Inc.
10.22 (4)      Letter of Agreement between the Registrant and
               Paramount Capital, Inc. dated February 26,
               1997.
10.23 (4)      Agreement and Plan of Reorganization by and
               among Atlantic Pharmaceuticals, Inc., Channel
               Therapeutics, Inc. and New Channel, Inc. dated
               February 20, 1997.
10.24 (4)      Warrant issued to John Prendergast to purchase
               37,500 shares of the Registrant's Common Stock.
10.25 (4)      Warrant issued to Ms. Dian Griesel to purchase
               24,000 shares of the Registrant's Common Stock.
21.1 (1)       Subsidiaries of the Registrant.
23.1*          Consent of KPMG Peat Marwick LLP.
23.2           Consent of Brobeck, Phleger & Harrison LLP
               (included in the opinion filed as Exhibit 5.1).
24.1           Power of Attorney (included in Part II of this
               Registration Statement under the caption
               "Signatures").
27.1           Financial Data Schedule.

- ------------------

 *  To be filed by amendment.
(1) Incorporated by reference to exhibits of the Registrant's Registration
    Statement on Form SB-2, No. 33-98478, as filed with the Securities and
    Exchange Commission (the "Commission") on October 24, 1995, and as amended
    by Amendment No. 1, Amendment No. 2, Amendment No. 3, Amendment No. 4 and
    Amendment No. 5, as filed with the Commission on November 9, 1995,
    December 5, 1995, December 12, 1995, December 13, 1995 and December 14,
    1995, respectively.
(2) Incorporated by reference to exhibits of the Registrant's Current Report on
    Form 8-KSB, as filed with the Commission on August 30, 1996.
(3) Incorporated by reference to exhibits of the Registrant's Quarterly Report
    on Form 10-QSB for the period ended September 30, 1996.
(4) Incorporated by reference to exhibits of the Registrant's Quarterly Report
    on Form 10-QSB for the period ended March 31, 1997.
(5) Incorporated by reference to exhibits of the Registrant's Report on Form
    8-KSB, as filed with the Commission on June 9, 1997.
+   Confidential treatment has been granted with respect to certain portions of
    this Exhibit.


                                         II-3
<PAGE>

ITEM 17.  UNDERTAKINGS

    The Registrant hereby undertakes that it will:

         (1)  File, during any period in which it offers or sells securities, a
    post-effective amendment to this Registration Statement to:

         (i)  Include any prospectus required by Section 10(a)(3) of the
         Securities Act;

         (ii) Reflect in the prospectus any facts or events which, individually
         or together, represent a fundamental change in the information in the
         Registration Statement.  Notwithstanding the foregoing, any increase
         or decrease in volume of securities offered (if the total dollar value
         of securities offered would not exceed that which was registered) and
         any deviation from the low or high end of the estimated maximum
         offering range may be reflected in the form of prospectus filed with
         the Commission pursuant to Rule 424(b) if, in the aggregate, the
         changes in volume and price represent no more than a 20 percent change
         in the maximum aggregate offering price set forth in the "Calculation
         of Registration Fee" table in the effective Registration Statement;
         and

         (iii)     Include any additional or changed material information on
         the plan of distribution.

         (2)  For determining liability under the Securities Act, treat each
    post-effective amendment as a new registration statement of the securities
    offered, and the offering of such securities at that time to be the initial
    BONA FIDE offering.

         (3)  File a post-effective amendment to remove from registration any
    of the securities that remain unsold at the end of the offering.

    Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the Delaware General Corporation Law, the Certificate of
Incorporation or the Bylaws of the Registrant, or otherwise, the Registrant has
been advised that in the opinion of the Securities and Exchange Commission such
indemnification is against public policy as expressed in the Securities Act, and
is, therefore, unenforceable.  In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer, or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered hereunder, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of
appropriate jurisdiction the question of whether such indemnification by it is
against public policy as expressed in the Securities Act and will be governed by
the final adjudication of such issue.

    The Registrant hereby undertakes that:

         (1)  For determining any liability under the Securities Act, treat the
    information omitted from the form of Prospectus filed as part of this
    Registration Statement in reliance upon Rule 430A and contained in a form
    of prospectus filed by the Registrant pursuant to Rule 424(b)(1) or (4) or
    497(h) under the Securities Act shall be deemed to be part of this
    Registration Statement as of the time the Commission declared it effective.

         (2)  For determining any liability under the Securities Act, treat
    each post-effective amendment that contains a form of prospectus as a new
    registration statement for the securities offered in the registration
    statement, and that offering of the securities at that time as the initial
    BONA FIDE offering of those securities.



                                         II-4

<PAGE>

                                      SIGNATURES

    Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and authorized this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Raleigh, State of North Carolina, on this 25th day of
August, 1997.

                                           ATLANTIC PHARMACEUTICALS, INC.

                                           By: /s/ Jon D. Lindjord
                                               ---------------------------------
                                                   Jon D. Lindjord
                                           President and Chief Executive Officer

                                  POWER OF ATTORNEY

    KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints, jointly and severally, Jon D. Lindjord
and Margaret A. Schalk, and each one of them, his true and lawful
attorneys-in-fact and agents, each with full power of substitution, for him and
in his name, place and stead, in any and all capacities, to sign any and all
amendments (including post-effective amendments) to this Registration Statement,
and to sign any registration statement for the same offering covered by this
Registration Statement that is to be effective upon filing pursuant to Rule
462(b) promulgated under the Securities Act of 1933, and all post-effective
amendments thereto, and to file the same, with all exhibits thereto and all
documents in connection therewith, with the Securities and Exchange Commission,
granting unto said attorneys-in-fact and agents, and each of them full power and
authority to do and perform each and every act and thing requisite and necessary
to be done in and about the premises, as fully to all intents and purposes as he
might or could do in person, hereby ratifying and confirming that each of said
attorneys-in-fact and agents or any of them, or his or their substitute or
substitutes, may lawfully do or cause to be done by virtue hereof.

    IN WITNESS WHEREOF, each of the undersigned has executed this Power of
Attorney as of the date indicated.

    Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the persons whose signatures
appear below, which persons have signed such Registration Statement in the
capacities and on the dates indicated:

<TABLE>
<CAPTION>

         Signature                              Title                          Date
         ---------                              -----                          ----
<S>                                     <C>                                <C>
 /s/ Jon D. Lindjord                   President and Chief Executive      August 25, 1997
- ----------------------------------     Officer (Principal Executive
    Jon D. Lindjord                    Officer) and a Director

 /s/ Shimshon Mizrachi                 Controller (Principal Financial    August 25, 1997
- ----------------------------------     and Accounting Officer)
    Shimshon Mizrachi

 /s/ John K.a. Prendergast             Director                           August 25, 1997
- ----------------------------------
    John K.A. Prendergast, Ph.D.

                                       Director                           August   , 1997
- ----------------------------------
    Steve H. Kanzer

 /S/ Yuichi Iwaki                      Director                           August 25, 1997
- ----------------------------------
    Yuichi Iwaki, M.D.

</TABLE>


                                         II-5

<PAGE>

                                    EXHIBIT INDEX

Exhibit No.    Description                                           Page Number

3.1 (1)       Certificate of Incorporation of the Registrant,
              as amended to date.
3.2 (1)       Bylaws of the Registrant, as amended to date.
3.3 (5)       Certificate of Designations of Series A
              Convertible Preferred Stock.
3.4           Certificate of Increase of Series A Convertible
              Preferred Stock.
4.2 (1)       Form of Unit certificate.
4.3 (1)       Specimen Common Stock certificate.
4.4 (1)       Form of Redeemable Warrant certificate.
4.5 (1)       Form of Redeemable Warrant Agreement, by and
              between the Registrant and Continental Stock
              Transfer & Trust Company.
4.6 (1)       Form of Underwriter's Warrant certificate.
4.7 (1)       Form of Underwriter's Warrant Agreement by
              and between the Registrant and Joseph Stevens &
              Company, L.P
4.8 (1)       Form of Subscription Agreement, by and between
              the Registrant and the Selling Securityholders.
4.9 (1)       Form of Bridge Note.
4.10 (1)      Form of Bridge Warrant.
4.11 (2)      Investors' Rights Agreement by and among the
              Registrant, Dreyfus Growth and Value Funds, Inc.
              and Premier Strategic Growth Fund.
4.12 (2)      Common Stock Purchase Agreement by and among the
              Registrant, Dreyfus Growth and Value Funds, Inc.
              and Premier Strategic Growth Fund
5.1           Opinion of Brobeck, Phleger & Harrison LLP.
10.1 (1)      The Registrant's 1995 Stock Option Plan.
10.2 (1)      Employment Agreement, dated July 7, 1995, between
              the Registrant and Jon D. Lindjord.
10.3 (1)      Employment Agreement, dated September 21, 1995,
              between the Registrant and Dr. Stephen R. Miller.
10.4 (1)      Employment Agreement, dated September 21, 1995,
              between the Registrant and Margaret A. Schalk.
10.5 (1)      Letter Agreement, dated August 31, 1995, between
              the Registrant and Dr. H. Lawrence Shaw.
10.6 (1)      Consulting Agreement, dated January 1, 1994,
              between the Registrant and John K.A. Prendergast.
10.7 (1)      (Reserved)
10.8 (1)      Investors' Rights Agreement, dated July, 1995,
              between the Registrant, Dr. Lindsay A. Rosenwald
              and VentureTek, L.P.
10.9 (1)      License and Assignment Agreement, dated
              March 25, 1994, between Optex Ophthalmologics,
              Inc., certain inventors and NeoMedix Corporation,
              as amended.
10.10 (1)     License Agreement, dated May 5, 1994, between
              Gemini Gene Therapies, Inc. and The Cleveland
              Clinic Foundation.
10.11 (1) +   License Agreement, dated June 16, 1994,
              between Channel Therapeutics, Inc., the University
              of Pennsylvania and certain inventors, as amended.
10.12 (1) +   License Agreement, dated March 28, 1994, between
              Channel Therapeutics, Inc. and Dr. Sumner Burstein.
10.13 (1)     Form of Financial Advisory and Consulting Agreement
              by and between the Registrant and Joseph Stevens &
              Company, L.P.
10.14 (1)     Employment Agreement, dated November 3, 1995,
              between the Registrant and Shimshon Mizrachi.
10.15 (3)     Financial agreement between the Registrant
              and Paramount dated September 4, 1996 (effective
              date of April 15, 1996).
10.16 (3)     Financial agreement between the Registrant, Paramount
              and UI USA dated June 23, 1996.


                                         II-6
<PAGE>

10.17 (3)     Consultancy agreement between the Registrant and
              Dr. Yuichi Iwaki dated July 31, 1996.
10.18 (3)     1995 Stock Option Plan, as amended.
10.19 (3)     Warrant to purchase 25,000 shares of Common Stock
              issued to Paramount Capital, Inc.
10.20 (3)     Warrant to purchase 25,000 shares of Common Stock
              issued to Paramount Capital, Inc.
10.21 (3)     Warrant to purchase 12,500 shares of Common Stock
              issued to Paramount Capital, Inc.
10.22 (4)     Letter of Agreement between the Registrant and
              Paramount Capital, Inc. dated February 26, 1997.
10.23 (4)     Agreement and Plan of Reorganization by and among
              Atlantic Pharmaceuticals, Inc., Channel Therapeutics,
              Inc. and New Channel, Inc. dated February 20, 1997.
10.24 (4)     Warrant issued to John Prendergast to purchase 37,500
              shares of the Registrant's Common Stock.
10.25 (4)     Warrant issued to Ms. Dian Griesel to purchase
              24,000 shares of the Registrant's Common Stock.
21.1 (1)      Subsidiaries of the Registrant.
23.1*         Consent of KPMG Peat Marwick LLP.
23.2          Consent of Brobeck, Phleger & Harrison LLP (included
              in the opinion filed as Exhibit 5.1).
24.1          Power of Attorney (included in Part II of this
              Registration Statement under the caption
              "Signatures").
27.1          Financial Data Schedule.

- --------------------

 *  To be filed by amendment.
(1) Incorporated by reference to exhibits of the Registrant's Registration
    Statement on Form SB-2, No. 33-98478, as filed with the Securities and
    Exchange Commission (the "Commission") on October 24, 1995, and as amended
    by Amendment No. 1, Amendment No. 2, Amendment No. 3, Amendment No. 4 and
    Amendment No. 5, as filed with the Commission on November 9, 1995,
    December 5, 1995, December 12, 1995, December 13, 1995 and December 14,
    1995, respectively.
(2) Incorporated by reference to exhibits of the Registrant's Current Report on
    Form 8-KSB, as filed with the Commission on August 30, 1996.
(3) Incorporated by reference to exhibits of the Registrant's Quarterly Report
    on Form 10-QSB for the period ended September 30, 1996.
(4) Incorporated by reference to exhibits of the Registrant's Quarterly Report
    on Form 10-QSB for the period ended March 31, 1997.
(5) Incorporated by reference to exhibits of the Registrant's Report on Form
    8-KSB, as filed with the Commission on June 9, 1997.
+   Confidential treatment has been granted with respect to certain portions of
    this Exhibit.


                                         II-7

<PAGE>

                               CERTIFICATE OF INCREASE
                                          OF
                         SERIES A CONVERTIBLE PREFERRED STOCK
                                          OF
                            ATLANTIC PHARMACEUTICALS, INC.

                PURSUANT TO SECTION 151 OF THE GENERAL CORPORATION LAW
                               OF THE STATE OF DELAWARE


         Atlantic Pharmaceuticals, Inc. (the "Corporation"), a corporation
organized and existing under the General Corporation Law of the State of
Delaware, in accordance with the provisions of Section 151(g) thereof, DOES
HEREBY CERTIFY:

         That pursuant to the authority conferred upon the Board of Directors
by Section B of Article Four of the Restated Certificate of Incorporation, the
Board of Directors of the Corporation adopted on August 7, 1997 the following
resolution increasing the number of authorized shares of Series A Convertible
Preferred Stock, par value $0.001 per share, of the Corporation:


              RESOLVED, that the number of shares of Series A
              Convertible Preferred Stock, par value $0.001 per
              share, of the Corporation be increased from
              1,100,000 to 1,375,000, and that the appropriate
              officers of the Corporation be, and each of them
              hereby is, authorized to prepare or cause to be
              filed with the Secretary of State of the State of
              Delaware a Certificate of Increase increasing the
              number of shares constituting Series A Convertible
              Preferred Stock, par value $0.001 per share, from
              1,100,000 to 1,375,000.


         IN WITNESS WHEREOF, the Corporation has caused this certificate to be
duly executed this 7th day of August, 1997.


                             ATLANTIC PHARMACEUTICALS, INC.


                             By: /s/ Jon D. Lindjord
                                 -------------------
                                  Jon D. Lindjord,
                                  President and Chief Executive Officer

<PAGE>

                   [LETTERHEAD OF BROBECK, PHLEGER & HARRISON LLP]

                                   August 25, 1997



Atlantic Pharmaceuticals, Inc.
North Carolina State University
1017 Main Campus Drive
Suite 3900
Raleigh, North Carolina  27606

Ladies and Gentlemen:

         We have acted as counsel to Atlantic Pharmaceuticals, Inc., a Delaware
corporation (the "Company"), in connection with the registration of up to Two
Hundred Fifty Thousand (250,000) shares of the Company's Common Stock (the
"Shares"), as described in the Company's Registration Statement on Form S-3
filed with the Securities and Exchange Commission on August 25, 1997 under the
Securities Act of 1933, as amended (the "Registration Statement").  

         We have examined originals or copies of (i) the Amended and Restated
Certificate of Incorporation of the Company; (ii) the Certificate of
Designations of Preferences of Series A Preferred Stock of the Company;
(iii) the Certificate of Increase of Series A Preferred Stock of the Company;
(iv) the Bylaws of the Company; (v) certain resolutions of the Board of
Directors of the Company; and (vi) such other documents and records as we have
deemed necessary and relevant for the purposes hereof.  In addition, we have
relied on certificates of officers of the Company and certificates of public
officials as to certain matters of fact relating to this opinion and have made
such investigations of law as we have deemed necessary and relevant as a basis
hereof.  

         We have assumed the genuineness of all signatures, the authenticity of
all documents, certificates and records submitted to us as originals, the
conformity to authentic original documents, certificates and records of all such
documentation submitted to us as copies and the truthfulness of all statements
of facts contained therein.  Based on the foregoing and subject to the
limitations set forth herein and having due regard for such legal considerations
as we deem relevant, we are of the opinion that the Shares, when issued and sold
in the manner described in the Registration Statement, will be validly issued,
fully paid and nonassessable shares of the Common Stock.  

<PAGE>

Atlantic Pharmaceuticals, Inc.                                  August 25, 1997
                                                                          Page 2

         The foregoing opinion is based on and limited to the General
Corporation Law of the State of Delaware and the relevant federal laws of the
United States, and we express no opinion with respect to the laws of any other
jurisdiction.  

         We consent to the use of this opinion as an exhibit to the
Registration Statement, and further consent to the use of our name wherever
appearing in the Registration Statement, including the prospectus constituting a
part thereof, and in any amendment or supplement thereto.  

                                  Very truly yours,

                                  /s/ Brobeck, Phleger & Harrison LLP

                                  BROBECK, PHLEGER & HARRISON LLP

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM FINANCIAL
STATEMENTS FOR THE PERIOD ENDED JUNE 30, 1997 AND IS QUALIFIED IN ITS ENTIRETY
BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          JUN-30-1997
<PERIOD-END>                               JUN-30-1997
<CASH>                                       2,310,163
<SECURITIES>                                         0
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                             2,353,286
<PP&E>                                         288,939
<DEPRECIATION>                                  88,328
<TOTAL-ASSETS>                               2,538,897
<CURRENT-LIABILITIES>                          364,387
<BONDS>                                              0
                                0
                                        230
<COMMON>                                         3,017
<OTHER-SE>                                  13,415,844
<TOTAL-LIABILITY-AND-EQUITY>                 2,538,897
<SALES>                                              0
<TOTAL-REVENUES>                                 2,288
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                             2,763,940
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                            (45,073)
<INCOME-PRETAX>                            (2,837,693)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                        (2,837,693)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                               (2,837,693)
<EPS-PRIMARY>                                    (.97)
<EPS-DILUTED>                                    (.97)
        

</TABLE>


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