ATLANTIC PHARMACEUTICALS INC
5, 2000-02-15
PHARMACEUTICAL PREPARATIONS
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
FORM 5
              ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

|_| Check box if no longer subject to Section 16.  Form 4 or Form 5
    obligations may continue. See Instruction 1(b).
|_| Form 3 Holdings Reported
|_| Form 4 Transactions Reported

1. Name and Address of Reporting Person
   Rudick, A. Joseph
   150 Broadway Avenue, Suite 1110
   New York, New York  10038

2. Issuer Name and Ticker or Trading Symbol

   Atlantic Pharmaceuticals, Inc. ("ATLC")

3. IRS or Social Security Number of Reporting Person (Voluntary)

4. Statement for Month/Year
   02/00

5. If Amendment, Date of Original (Month/Year)

6. Relationship  of Reporting  Person(s) to Issuer  (Check all  applicable)
   (X) Director  ( ) 10% Owner  (X)  Officer  (give  title  below)
   ( ) Other  (specify below)

      President

7. Individual or Joint/Group Reporting (Check Applicable Line)
   (X) Form filed by One Reporting Person
   ( ) Form filed by More than One Reporting Person
<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------------------
 Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned                                                 |
- -----------------------------------------------------------------------------------------------------------------------------------|
1. Title of Security         |2.    |3.  |4.Securities Acquired (A)         |5.Amount of        |6.Dir |7.Nature of Indirect       |
                             |Transaction|  or Disposed of (D)              |  Securities       |ect   |  Beneficial Ownership     |
                             |Date  |Code|  (Instr.3,4 and 5)               |  Beneficially     |(D)or |  (Instr. 4)               |
                             |      |(Ins|                  | A/|           |  Owned at         |Indir |                           |
                             |      |tr.8)    Amount        | D |    Price  |  End of Year      |ect(I)|                           |
                             |           |                  |   |           |  (Instr. 3 and 4) |(Ins  |                           |
                             |           |                  |   |           |                   | tr.4)|                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
<S>                          <C>    <C>  <C>                <C> <C>         <C>                 <C>    <C>
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
                             |      |    |                  |   |           |                   |      |                           |
- -----------------------------------------------------------------------------------------------------------------------------------|
</TABLE>

*If form is filed by more than one reporting  person,  see instruction  4(b)(v).
(Over) SEC 2270(7-96)

<PAGE>

FORM 5 (continued)

  Table  II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

<TABLE>
<CAPTION>
- -----------------------------------------------------------------------------------------------------------------------------------
 Table II -- Derivative Securitites Acquired, Disposed of, or Beneficially Owned                                                   |
- -----------------------------------------------------------------------------------------------------------------------------------|
1.Title of Derivative   |2.Con   |3.   |4.  |5.Number of De |6.Date Exer|7.Title and Amount  |8.Price|9.Number    |10.|11.Nature of|
  Security              |version |Transaction rivative Secu |cisable and|  of Underlying     |of Deri|of Deriva   |Dir|Indirect    |
                        |or Exer |Date |Code| rities Acqui  |Expiration |  Securities        |vative |tive        |ect|Beneficial  |
                        |cise Pr |     |(In | red(A) or Dis |Date(Month/|  (Instr. 3 and 4   |Secu   |Securities  |(D)|Ownership   |
                        |ice  of |     |str.| posed of(D)   |Day/Year)  |                    |rity   |Benefi      |or |            |
                        |Deriva  |     | 8) | (Instr.3,4    |Date |Expir|                    |(Instr.|ficially    |Ind|            |
                        |tive    |     |    |  and 5)   | A/|Exer-|ation|   Title and Number | 5)    |Owned at    |ire|            |
                        |Secu    |     |    |           | D |cisa-|Date |   of Shares        |       |End of      |ct |            |
                        |rity    |     |    |  Amount   |   |ble  |     |                    |       |Year        |(I)|            |
                        |        |     |    |           |   |     |     |                    |       |(Instr. 4)  |(Instr. 4)      |
- -----------------------------------------------------------------------------------------------------------------------------------|
<S>                     <C>      <C>   <C>  <C>         <C> <C>   <C>   <C>           <C>    <C>     <C>          <C> <C>
                        |        |     |    |           |   |     |     |            |       |       |            |   |            |
                        |        |     |    |           |   |     |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option            |$3.25   |     |3(1)| 10,000    |   |8/7/ |8/6/ |Common      |10,000 |       |            | D |            |
(right to buy)          |        |     |    |           |   |99(2)|08   |Stock       |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option            |$1.375  |5/28/| A  | 10,000    |   |5/28/|5/27/|Common      |10,000 |       |            | D |            |
(right to buy)          |        |  99 |    |           |   |99(3)|09   |Stock       |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option            |$1.313  |8/9/ | A  | 50,000    |   | (4) |8/8/ |Common      |50,000 |       |            | D |            |
(right to buy)          |        | 99  |    |           |   |     |09   |Stock       |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option            |$1.75   |9/23/| A  |  2,000    |   |9/23/|9/22/|Common      | 2,000 |       |            | D |            |
(right to buy)          |        | 99  |    |           |   |99(5)| 09  |Stock       |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
Stock Option            |$1.50   |8/9/ | A  | 25,000    |   | (6) |10/20|Common      |25,000 |       | 97,000     | D |            |
(right to buy)          |        | 99  |    |           |   |     |09   |Stock       |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
                        |        |     |    |           |   |     |     |            |       |       |            |   |            |
                        |        |     |    |           |   |     |     |            |       |       |            |   |            |
- -----------------------------------------------------------------------------------------------------------------------------------|
</TABLE>

(1)       The reporting  person held 10,000 stock  options on May 18, 1999,  the
          date  that  the  reporting   person  became  a  director  of  Atlantic
          Pharmaceuticals, Inc.
(2)       One-third of the option became  exercisable  on August 7, 1999 and the
          balance of the option is exercisable in 24 equal monthly  installments
          thereafter.
(3)       The option vests in three equal annual  installments  beginning on May
          28, 2000.
(4)       The option vests in four equal annual installments beginning on August
          8, 2000.  The option may only be exercised if the fair market value of
          the Common Stock is equal to or greater than $3.50 per share.
(5)       The option vests on September 23, 2000
(6)       The option  vests  immediately  but may only be  exercised if the fair
          market value of the Common Stock is equal to or greater than $3.50 per
          share.

                         A. Joseph Rudick

                         /s/ A. Joseph Rudick                February 9, 2000
                        -------------------------------      ----------------
                         ** Signature of Reporting Person         Date

Note:   File three copies of this Form, one of which must be manually signed.
            If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information  contained
in this form are not  required to respond  unless the form  displays a currently
valid OMB number. Page 2


                                                                 SEC 2270 (7-96)




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