ILEX ONCOLOGY INC
SC 13G, 1998-02-17
MEDICAL LABORATORIES
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<PAGE>
                              UNITED STATES
                     SECURITIES AND EXCHANGE COMMISSION
                          Washington, D.C. 20549

                              SCHEDULE 13G

                 Under the Securities Exchange Act of 1934
                          (Amendment No.       )*
                                         ------

                            Ilex Oncology, Inc.
                     ----------------------------------
                              (Name of Issuer)

                        Common Stock $.01 par value
                     ----------------------------------
                       (Title of Class of Securities)

                                0004519231
                     ----------------------------------
                              (CUSIP Number)


   *The remainder of  this cover  page  shall  be  filled  out  for a reporting
person's  initial  filing on this  form with  respect to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter the disclosures provided in a prior page.

   The information  required in the  remainder of this  cover page shall not be
deemed to be "filed"  for the purpose of  Section 18 of the Securities Exchange
Act of 1934  ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however, see
the Notes).





<PAGE>

           

- -------------------------------------------------------------------------------
 (1) Name of Reporting Person S.S. or I.R.S. Identification No. of Above
     Person

     Cross Atlantic Partners K/S
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization
     Denmark
- -------------------------------------------------------------------------------
Number of Shares              (5) Sole Voting Power 
 Beneficially                      -0- shares
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                       759,940 shares
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  -0- shares
                             --------------------------------------------------
                              (8) Shared Dispositive Power
                                  759,940 shares
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     759,940 shares
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*

- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row (9)
     6.2%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*
     PN
- -------------------------------------------------------------------------------

                              Page 2  of  15  Pages
<PAGE>

               

- -------------------------------------------------------------------------------
 (1) Name of Reporting Person  S.S. or I.R.S. Identification No. of Above
     Person

     Cross Atlantic Partners K/S II
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization
     Denmark
- -------------------------------------------------------------------------------
Number of Shares              (5) Sole Voting Power
 Beneficially                     -0- shares
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                      759,940 shares
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  -0- shares
                             --------------------------------------------------
                              (8) Shared Dispositive Power
                                  759,940 shares
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     759,940 shares
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*

- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row (9)
     6.2%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*
     PN
- -------------------------------------------------------------------------------

                              Page  3   of 15  Pages


<PAGE>

                                      
- -------------------------------------------------------------------------------
 (1) Name of Reporting Person  S.S. or I.R.S. Identification No. of Above
     Person

     CAP/Hambro, L.P.
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization
     Delaware
- -------------------------------------------------------------------------------
Number of Shares              (5) Sole Voting Power
 Beneficially                      -0-
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                      759,940 shares
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  -0-
                             --------------------------------------------------
                              (8) Shared Dispositive Power
                                  759,940 shares
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     759,940 shares
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*

- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row (9)
     6.2%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*
     PN
- -------------------------------------------------------------------------------

                              Page 4   of 15  Pages
<PAGE>

                                    
- -------------------------------------------------------------------------------
 (1) Name of Reporting Person  S.S. or I.R.S. Identification No. of Above
     Person

     CAP/Hambro, Inc.
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization
     Delaware
- -------------------------------------------------------------------------------
Number of Shares              (5) Sole Voting Power
 Beneficially                     -0-    
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                      759,940 shares
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  -0- 
                             --------------------------------------------------
                              (8) Shared Dispositive Power
                                  759,940 shares
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     759,940 shares
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*

- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row (9)
     6.2%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*
     CO
- -------------------------------------------------------------------------------

                              Page 5   of 15  Pages
<PAGE>

                                     
- -------------------------------------------------------------------------------
 (1) Name of Reporting Person  S.S. or I.R.S. Identification No. of Above
     Person

     Hambro America, Inc.
- -------------------------------------------------------------------------------
 (2) Check the Appropriate Box if a Member     (a)  / /
     of a Group*                               (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC Use Only

- -------------------------------------------------------------------------------
 (4) Citizenship or Place of Organization
     New York
- -------------------------------------------------------------------------------
Number of Shares              (5) Sole Voting Power
 Beneficially                     -0-
 Owned by                    --------------------------------------------------
 Each Reporting               (6) Shared Voting Power
 Person With                      759,940 shares
                             --------------------------------------------------
                              (7) Sole Dispositive Power
                                  -0-
                             --------------------------------------------------
                              (8) Shared Dispositive Power 
                                  759,940 shares
- -------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person
     759,940 shares
- -------------------------------------------------------------------------------
(10) Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*

- -------------------------------------------------------------------------------
(11) Percent of Class Represented by Amount in Row (9)
     6.2%
- -------------------------------------------------------------------------------
(12) Type of Reporting Person*
     CO
- -------------------------------------------------------------------------------
           
                              Page  6  of 15  Pages

<PAGE>

NOTE:  This Statement on Schedule 13G is being filed on behalf of Cross 
Atlantic Partners K/S, Cross Atlantic Partners K/S II, CAP/Hambro, L.P., 
CAP/Hambro, Inc. and Hambro America, Inc. CAP/Hambro, L.P. is the sole 
general partner of Cross Atlantic Partners, K/S and Cross Atlantic Partners 
K/S II. CAP/Hambro, Inc. is the sole general partner of CAP/Hambro, L.P. 
Hambro America, Inc. is the sole shareholder of CAP/Hambro, Inc.

                                                               

ITEM 1(A).  NAME OF ISSUER Ilex Oncology, Inc.
- -------------------------------------------------------------------------------


ITEM 1(B).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES
            11550 IH-10 West Suite 300
            San Antonio, TX 78230
- -------------------------------------------------------------------------------


     ITEM 2(A).                        Item 2(b)               Item 2(c)

                                                           Citizenship or Place
NAME OF PERSON FILING                   Address              of Organization 

Cross Atlantic Partners K/S, a       c/o Hambro Health           Denmark
Danish limited partnership           International, Inc.
                                     650 Madison Avenue
                                     New York, NY  10022

Cross Atlantic Partners K/S II, a    c/o Hambro Health           Denmark
Danish limited partnership           International, Inc.
                                     650 Madison Avenue
                                     New York, NY  10022

CAP/Hambro, L.P., the sole           c/o Hambro Health            Delaware
 general partner of Cross            International, Inc.
 Atlantic Partners K/S and           650 Madison Avenue 
 Cross Atlantic Partners K/S II      New York, NY  10022

CAP/Hambro, Inc., the sole general   c/o Hambro Health            Delaware
 partner of CAP/Hambro, L.P.,        International, Inc.
 which is wholly-owned by            650 Madison Avenue
 Hambro America, Inc.                New York, NY  10022

Hambro America, Inc., the parent     c/o Hambro Health            New York
 corporation of CAP/Hambro,          International, Inc.
  Inc.                               650 Madison Avenue
                                     New York, NY  10022

ITEM 2(D).  TITLE OF CLASS OF SECURITIES Common Stock $.01 par value.

ITEM 2(E).  CUSIP NUMBER 0004519231

ITEM 3.  IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b), OR 13d-2(b),
         CHECK WHETHER THE PERSON FILING IS A

         (a) / / Broker or Dealer registered under Section 15 of the 
                 Securities Exchange Act of 1934 (the "Act").

         (b) / / Bank as defined in section 3(a)(6) of the Act.

                             Page  7 of  15  Pages

<PAGE>


         (c) / / Insurance Company as defined in section 3(a)(19) of the Act.

         (d) / / Investment Company registered under section 8 of the 
                 Investment Company Act of 1940.

         (e) / / Investment Adviser registered under section 203 of the 
                 Investment Advisers Act of 1940.

         (f) / / Employee Benefit Plan, Pension Fund which is subject to the
                 provisions of the Employee Retirement Income Security Act of 
                 1974 or Endowment Fund; see Rule 13d-1(b)(1)(ii)(F) of the Act.

         (g) / / Parent Holding Company, in accordance with 
                 Rule 13d-1(b)(ii)(G).
                
         (h) / / Group, in accordance with Rule 13d-1(b)(1)(ii)(H).

         None of the above.

ITEM 4.  OWNERSHIP

    (a) Amount Beneficially Owned: As of December 31, 1997, each of the 
        following is the owner of record of the number of shares of Common 
        Stock set forth next to its name:
 
        Cross Atlantic Partners K/S          699,505 shares
        Cross Atlantic Partners K/S II       36,883 shares
        CAP/Hambro, L.P.                          0 shares
        CAP/Hambro, Inc.                          0 shares
        Hambro America, Inc.                      0 shares

        Additionally, Cross Atlantic Partners K/S and Cross Atlantic Partners
        K/S II hold presently exerciseable warrants to purchase 14,468 shares
        and 9,084 shares, respectively, of Common Stock. Therefore, CAP/Hambro
        L.P., CAP/Hambro, Inc., and Hambro America, Inc. (collectively the
        "Entities") may be deemed to beneficially own the shares and
        exerciseable warrants owned by Cross Atlantic Partners K/S and Cross 
        Atlantic Partners K/S II.  Hence Cross Atlantic Partners K/S, Cross
        Atlantic Partners K/S II and the Entities may be deemed to own 
        beneficially an aggregate of 759,940 shares  (Common Stock and 
        Warrants).

    (b) Percent of Class:

        Cross Atlantic Partners K/S            6.2%
        Cross Atlantic Partners K/S II         6.2%
        CAP/Hambro, L.P.                       6.2%
        CAP/Hambro, Inc.                       6.2%
        Hambro America, Inc.                   6.2%

        The foregoing percentages are calculated based on the 12,278,500 shares
        of Common Stock reported to be outstanding in the Quarterly Report on 
        Form 10-Q of Ilex Oncology, Inc. for the quarter ended September 30, 
        1997, as adjusted pursuant to Rule 13d-3 (d)(1) of the Act.

    (c) Number of shares as to which such person has:


                              Page  8  of 15 Pages

<PAGE>
  


          (i) sole power to vote or to direct the vote
          
              Cross Atlantic Partners K/S       0 shares
              Cross Atlantic Partners K/S II    0 shares
              CAP/Hambro, L.P.                  0 shares
              CAP/Hambro, Inc.                  0 shares
              Hambro America, Inc.              0 shares

         (ii) shared power to vote or to direct the vote

              Cross Atlantic Partners K/S       759,940 shares
              Cross Atlantic Partners K/S II    759,940 shares
              CAP/Hambro, L.P.                  759,940 shares
              CAP/Hambro, Inc.                  759,940 shares
              Hambro America, Inc.              759,940 shares

        (iii) sole power to dispose or to direct the disposition of

              Cross Atlantic partners K/S       0 shares
              Cross Atlantic Parnters K/S II    0 shares
              CAP/Hambro, L.P.                  0 shares
              CAP/Hambro, Inc.                  0 shares
              Hambro America, Inc.              0 shares


         (iv) shared power to dispose or to direct the disposition of

              Cross Atlantic Partners K/S       759,940 shares
              Cross Atlantic Partners K/S II    759,940 shares
              CAP/Hambro, L.P.                  759,940 shares
              CAP/Hambro, Inc.                  759,940 shares
              Hambro America, Inc.              759,940 shares

              Cross Atlantic Partners K/S, Cross Atlantic Partners K/S II, 
              CAP/Hambro, L.P., CAP/Hambro, Inc., and Hambro America, Inc. 
              expressly disclaim beneficial ownership of any shares of Common
              Stock of Ilex Oncology, Inc., except any shares held directly
              of record.

ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

         If this statement is being filed to report the fact that as of the 
         date hereof the reporting person has ceased to be the beneficial 
         owner of more than five percent of the class of securities, check 
         the following.  / /


ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

         Not applicable
- -------------------------------------------------------------------------------


ITEM 7.  IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
         THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

         Not applicable
- -------------------------------------------------------------------------------


ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                           Page  9  of 15 Pages
<PAGE>


         Not applicable. Cross Atlantic Partners K/S, Cross Atlantic Partners 
         K/S II, CAP/Hambro, L.P., CAP/Hambro, Inc., and Hambro America, Inc.
         expressly disclaim membership in a "group" as defined in Rule 13d-1(b)
         (ii)(H).
- -------------------------------------------------------------------------------


ITEM 9.  NOTICE OF DISSOLUTION OF GROUP

         Not applicable
- -------------------------------------------------------------------------------


ITEM 10. CERTIFICATION

         Not applicable. This statement on Schedule 13G is not filed pursuant 
         to Rule 13d-1(b).

Attached as Exhibit 1 hereto is a Joint Filing Agreement executed by each of 
the filing persons pursuant to Rule 13d-1(f) under  Section 13(d) of the Act.

                                Page  10  of 15 Pages
<PAGE>



                         Signature
                                
     After reasonable inquiry and to the best of his, her or its knowledge 
and belief, each of the undersigned certifies that the information set forth 
in this statement is true, complete and correct.  We also hereby agree to 
file this   statement jointly pursuant to the agreement set forth as   
Exhibit 1 hereto.

Dated:  February 13, 1998
                ---

                              
                                       CROSS ATLANTIC PARTNERS K/S
                              
                                       By:  CAP/HAMBRO, L.P.
                                            Its General Partner
                              
                                       By:  CAP/HAMBRO, INC.
                                            Its General Partner
                              
                                       By:          *            
                                            ------------------------------
                                            Charles L. Dimmler, III
                                            Authorized Officer
                              
                                        CROSS ATLANTIC PARTNERS K/S II
                              
                                        By:  CAP/HAMBRO, L.P.
                                             Its General Partner
                              
                                        By:  CAP/HAMBRO, INC.
                                             Its General Partner
                              
                                        By:          *            
                                             -----------------------------
                                             Charles L. Dimmler, III
                                             Authorized Officer
                              
                                             CAP/HAMBRO, L.P.
                              
                                        By:  CAP/HAMBRO, INC.
                                             Its General Partner
                              
                                        By:          *            
                                             -----------------------------
                                             Charles L. Dimmler, III
                                             Authorized Officer
                              
                                             CAP/HAMBRO, INC.
                              
                                        By:         *            
                                             -----------------------------
                                             David Barnett
                                             Authorized Officer
                              
                                             HAMBRO AMERICA, INC.
                              
                                        By:         *            
                                             -----------------------------
                                             David Barnett
                                             Authorized Officer

                                Page  11  of 15 Pages                   

<PAGE>

                              
                              
                                       *By: /s/ Lisa C. Torch
                                            ------------------------------
                                            Lisa C. Torch
                                            Attorney-in-fact


*  This Schedule 13G was executed by Lisa C. Torch pursuant to Powers of 
Attorney attached hereto as Exhibit 2.

                                Page  12  of 15 Pages

<PAGE>


                                                                      Exhibit 1

                                     AGREEMENT
                               
          Pursuant to Rule 13d-1(f) (1) under the Securities Exchange Act 
of 1934, the undersigned hereby agree that only one statement containing 
the information required by Schedule 13G need be filed with respect to the 
ownership by each of the undersigned of shares of Common Stock of Ilex   
Oncology, Inc.
  
          This Agreement may be executed in any number of counterparts, 
each of which shall be deemed an original.
  
     EXECUTED this 13th day of February, 1998.
                  ---            

                                       CROSS ATLANTIC PARTNERS K/S
                              
                                       By:  CAP/HAMBRO, L.P.
                                            Its General Partner
                              
                                       By:  CAP/HAMBRO, INC.
                                            Its General Partner
                              
                                       By:          *            
                                            ------------------------------
                                            Charles L. Dimmler, III
                                            Authorized Officer
                              
                                       CROSS ATLANTIC PARTNERS K/S II
                              
                                       By:  CAP/HAMBRO, L.P.
                                            Its General Partner
                              
                                       By:  CAP/HAMBRO, INC.
                                            Its General Partner
                              
                                       By:          *            
                                            ------------------------------
                                            Charles L. Dimmler, III
                                            Authorized Officer
                              
                                            CAP/HAMBRO, L.P.
                              
                                        By:  CAP/HAMBRO, INC.
                                             Its General Partner
                              
                                        By:          *            
                                             -----------------------------
                                             Charles L. Dimmler, III
                                             Authorized Officer
                              
                                             CAP/HAMBRO, INC.
                              
                                        By:         *            
                                             -----------------------------
                                             David Barnett
                                             Authorized Officer 
                              
                              

                                Page  13  of 15 Pages

<PAGE> 
                             
                                             HAMBRO AMERICA, INC.
                              
                                        By:         *            
                                             -----------------------------
                                             David Barnett
                                             Authorized Officer
                              

                                       *By: /s/ Lisa C. Torch
                                            ------------------------------
                                            Lisa C. Torch
                                            Attorney-in-fact

          *  This Agreement was executed by Lisa C. Torch pursuant to Powers 
of Attorney attached hereto as Exhibit 2.




                                Page  14  of 15 Pages
<PAGE>


                                                                      Exhibit 2
                               
                      POWER OF ATTORNEY
                                
     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature 
appears below hereby constitutes and appoints Edwin A. Goodman and Lisa C. 
Torch, and each of them, with full power to act without the other, his or 
her true and lawful attorney-in-fact, with full power of substitution, to 
sign any and all instruments, certificates and documents that may be 
necessary, desirable or appropriate to be executed on behalf of himself or 
herself as an individual or in his or her capacity as a general partner 
of, or an officer of a general partner of, CAP/Hambro, L.P., CAP/Hambro, 
Inc., Hambro America, Inc., Cross Atlantic Partners K/S, Cross Atlantic 
Partners K/S II and Cross Atlantic Partners K/S III, pursuant to Section 13 
or 16 of the Securities Exchange Act of 1934, as amended (the "Exchange 
Act"), and any and all regulations promulgated thereunder, and to file the 
same, with all exhibits thereto, and any other documents in connection 
therewith, with the Securities and Exchange Commission, and with any other 
entity when and if such is mandated by the Exchange Act or by the By-laws 
of the National Association of Securities Dealers, Inc., granting unto said 
attorney-in-fact full power and authority to do and perform each and 
every act and thing necessary, desirable or appropriate, fully to all 
intents and purposes as he or she might or could do in person, thereby 
ratifying and confirming all that said attorney-in-fact, or his 
substitutes, may lawfully do or cause to be done by virtue hereto.
 
 
     IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 
13th day of February, 1998.
- --  

                                               /s/ John Cassis
                                               --------------------------
                                               John Cassis
                                   
                                               /s/ Charles L. Dimmler, III
                                               ---------------------------
                                               Charles L. Dimmler, III
  
                                               /s/ David Barnett
                                               ---------------------------
                                               David Barnett



                                Page  15  of 15 Pages
 


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