PHYMATRIX CORP
8-K, 1997-10-06
MISC HEALTH & ALLIED SERVICES, NEC
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K

                                 Current Report
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934



Date of Report (Date of earliest event reported):  October 6, 1997



                                 PHYMATRIX CORP.
              ----------------------------------------------------
             (Exact name of registrant as specified in its charter)



       Delaware                    000-27568                65-0617076
       --------                    ---------                ----------
 (State of incorporation         (Commission             (IRS Employer
   or organization)              File Number)          Identification No.)


                          Phillips Point, Suite 1000E
             777 South Flagler Drive, West Palm Beach, FL  33401
             -----------------------------------------------------
             (Address of principal executive offices)    (Zip Code)


       Registrant's telephone number, including area code: (561) 655-3500
                                                           -----------------

                                       N/A
              ----------------------------------------------------
         (Former name or former address, if changed since last report.)




<PAGE>



Item 2.  Acquisition or Disposition of Assets
         ------------------------------------
         Effective July 15, 1997, PhyMatrix Corp., a Delaware corporation (the
"Company"), entered into the Amended and Restated Agreement and Plan of Merger
(the "Merger Agreement") by and among the Company, PhyMatrix Acquisition I,
Inc., a Delaware corporation ("PhyMatrix Acquisition"), Clinical Studies Ltd., a
Delaware corporation ("CSL"), Dr. Michael Rothman, Dr. Walter Brown, Michael T.
Heffernan and Ronald Phillips as Trustee of The Alexander Rothman 1993 Qualified
Sub-Chapter S Trust and as Trustee of The Julie Rothman 1993 Qualified
Sub-Chapter S Trust. Pursuant to the Merger Agreement, PhyMatrix Acquisition, a
wholly-owned subsidiary of PhyMatrix, will merge with and into CSL (the
"Acquisition"), and CSL will become a wholly-owned subsidiary of PhyMatrix. CSL
is a site management organization conducting clinical research for
pharmaceutical companies and clinical research organizations at 22 centers
located in 11 states.

         PhyMatrix currently anticipates that, subject to the satisfaction of
certain remaining conditions to closing set forth in the Merger Agreement, the
Acquisition will be consummated on or about October 14, 1997. The Acquisition
will be treated for accounting purposes as a pooling of interests.

         The purchase price for CSL will be paid to the stockholders of CSL in
shares of PhyMatrix Common Stock. The number of shares of PhyMatrix Common Stock
to be issued in the Acquisition is based upon the average last reported sale
price per share for the five business days preceding the business day prior to
the closing of the Acquisition (the "Last Reported Sale Price"). Based upon the
current market price of PhyMatrix Common Stock (the closing price of PhyMatrix
Common Stock on October 1, 1997 was $15.625), PhyMatrix currently anticipates
that it will issue approximately 5.2 million shares of Common Stock under the
Merger Agreement to the stockholders of CSL. If the Last Reported Sale Price is
less than $13.50 or greater than $16.50, the Merger Agreement provides that the
number of shares to be issued to the stockholders of CSL would increase or
decrease, respectively. If the Last Reported Sale Price is $12.00 or less, each
of PhyMatrix and CSL has the option to terminate the Merger Agreement.

         Following the Acquisition, PhyMatrix has agreed to use its best efforts
to register under the Securities Act of 1933, as amended, the resale of the
shares of PhyMatrix Common Stock acquired in the Acquisition.

         In connection with the Acquisition, the management of PhyMatrix has
agreed to recommend Michael T. Heffernan, the Chief Executive Officer of CSL,
for election to the Board of Directors of PhyMatrix, and PhyMatrix and Mr.
Heffernan expect to enter into an employment agreement relating to Mr.
Heffernan's continued services as Chief Executive Officer of CSL.


                                       -2-

<PAGE>



Item 7.  Financial Statements and Exhibits.
         ---------------------------------
         (a)  Financial statements of business acquired.

         Included as a part of this Report are:

         (i)      Combined financial statements of CSL as of and for the years
                  ended December 31, 1996 and December 31, 1995 and Independent
                  Auditors' Report.

         (ii)     Combined financial statements of CSL as of and for the year
                  ended December 31, 1994 and Independent Auditors' Report.

         (b)  Pro forma financial information.

         Included as a part of this Report are:

         (i)      The Company's Unaudited Pro Forma Combined Balance Sheet as
                  of July 31, 1997, Unaudited Pro Forma Combined Statements of
                  Operations for the Six Months ended July 31, 1997, the year
                  ended January 31, 1997 and the years ended December 31, 1995
                  and December 31, 1994, respectively.


         (c)  Exhibits.

         The following exhibits are filed herewith.
+
         2.1      Amended and Restated Agreement and Plan of Merger dated as of
                  July 15, 1997 by and among the Company, PhyMatrix Acquisition
                  I, Inc., a Delaware corporation ("PhyMatrix Acquisition"),
                  Clinical Studies Ltd., a Delaware corporation ("CSL"), Dr.
                  Michael Rothman, Dr. Walter Brown, Michael T. Heffernan and
                  Ronald Phillips as Trustee of The Alexander Rothman 1993
                  Qualified Sub-Chapter S Trust and as Trustee of The Julie
                  Rothman 1993 Qualified Sub-Chapter S Trust.

         23.1     Consent of Deloitte & Touche LLP

         23.2     Consent of Sansiveri, Kimball & McNamee, L.L.P.

         27.1     Financial Data Schedule

                                       -3-


<PAGE>


CLINICAL STUDIES LTD.
AND CLINICAL MARKETING LTD.

COMBINED FINANCIAL STATEMENTS 
FOR THE YEARS ENDED DECEMBER 31, 1996 AND 1995 AND
INDEPENDENT AUDITORS' REPORT


TABLE OF CONTENTS
- --------------------------------------------------------------------------------

                                                                  Page

INDEPENDENT AUDITORS' REPORT                                        1

COMBINED FINANCIAL STATEMENTS FOR THE YEARS ENDED
  DECEMBER 31, 1996 AND 1995:

  Combined Balance Sheets                                           2

  Combined Statements of Operations                                 3

  Combined Statements of Stockholders' Equity                       4

  Combined Statements of Cash Flows                                 5

  Notes to Combined Financial Statements                          6-15



<PAGE>



<TABLE>
<CAPTION>
<S>                                 <C>                                              <C>
[LETTERHEAD]                        -----------------------------------------------------------------------------------------------
[LOGO Deloitte & Touche LLP]                125 Summer Street                        Telephone: (617) 261-8000
                                    Boston, Massachusetts 02110-1617                 Facsimile: (617) 261-8111
</TABLE>

INDEPENDENT AUDITORS' REPORT

To the Stockholders of
   Clinical Studies Ltd. And Clinical Marketing Ltd.
Providence, RI

We have audited the accompanying combined balance sheets of Clinical Studies
Ltd. ("CSL") and Clinical Marketing Ltd. ("CML") (collectively the "Companies")
as of December 31, 1996 and 1995, and the related combined statements of
operations, stockholders' equity and cash flows for the years then ended. These
financial statements are the responsibility of the Companies' management. Our
responsibility is to express an opinion on these financial statements based on
our audits.

We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

In our opinion, such combined financial statements present fairly, in all
material respects, the combined financial position of Clinical Studies Ltd. and
Clinical Marketing Ltd. as of December 31, 1996 and 1995, and the results of
their combined operations and their combined cash flows for the years then ended
in conformity with generally accepted accounting principles.


/s/ Deloitte & Touche LLP
May 28, 1997


- ---------------
Deloitte Touche
Tohmatsu
International
- -------------


<PAGE>



CLINICAL STUDIES LTD. AND CLINICAL MARKETING LTD.

COMBINED BALANCE SHEETS
DECEMBER 31, 1996 AND 1995
<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------------------------
ASSETS                                                                     1996                   1995
<S>                                                                    <C>                     <C> 
CURRENT ASSETS:
  Cash and cash equivalents                                            $ 1,428,276             $3,595,454
  Contract receivables (net of allowance for contract
    adjustments of $278,000 and $236,000 in 1996
    and 1995, respectively)                                              5,897,469              2,210,028
                                                                       -----------             ----------

        Total current assets                                             7,325,745              5,805,482
                                                                       -----------             ----------

PROPERTY AND EQUIPMENT:
  Furniture and office equipment                                           407,892                255,425
  Medical equipment                                                        343,138                285,249
  Vehicles                                                                  12,758                 12,758
                                                                       -----------             ----------

        Total                                                              763,788                553,432

  Less accumulated depreciation and amortization                          (302,019)              (178,669)
                                                                       -----------             ----------

        Property and equipment, net                                        461,769                374,763
                                                                       -----------             ----------

INTANGIBLE ASSETS, Net                                                   7,257,298                     --
                                                                       -----------             ----------

OTHER ASSETS                                                               141,546                 99,949
                                                                       -----------             ----------

TOTAL                                                                  $15,186,358             $6,280,194
                                                                       ===========             ==========

LIABILITIES AND STOCKHOLDERS'
  EQUITY                                                     

CURRENT LIABILITIES:
  Current portion of long-term debt                                    $    90,069             $   44,581
  Accounts payable and accrued expenses                                  1,707,955              1,432,086
  Deferred revenue                                                       1,182,224              1,940,180
                                                                       -----------             ----------

        Total current liabilities                                        2,980,248              3,416,847
                                                                       -----------             ----------

LONG-TERM DEBT-Less current portion                                      7,317,740                104,484
                                                                       -----------             ----------

COMMITMENTS AND CONTINGENCIES

STOCKHOLDERS' EQUITY: 
  Common stock: Clinical Studies Limited, no par value-
    authorized, 1,000 shares; issued
    and outstanding, 100 shares                                                100                    100
  Clinical Marketing Limited, no par value-
    authorized, 8,000 shares; issued
    and outstanding, 235 shares in 1996 and
    200 shares in 1995                                                     627,840                    200
  Additional paid-in capital                                               120,000                120,000
  Retained earnings                                                      4,140,430              2,638,563
                                                                       -----------             ----------

        Total stockholders' equity                                       4,888,370              2,758,863
                                                                       -----------             ----------

TOTAL                                                                  $15,186,358             $6,280,194
                                                                       ===========             ==========
</TABLE>

See notes to combined financial statements.

                                      -2-



<PAGE>




CLINICAL STUDIES LTD. AND CLINICAL MARKETING LTD.

COMBINED STATEMENTS OF OPERATIONS
YEARS ENDED DECEMBER 31, 1996 AND 1995
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------

                                                                           1996                       1995
<S>                                                                    <C>                        <C>
REVENUE                                                                $18,040,124                $13,351,843

OPERATING EXPENSES                                                      14,738,292                 10,444,639
                                                                       -----------                -----------

INCOME FROM OPERATIONS                                                   3,301,832                  2,907,204
                                                                       -----------                -----------

OTHER INCOME (EXPENSE):
  Interest income                                                           75,833                     42,242
  Interest expense                                                        (144,206)                   (18,271)
                                                                       -----------                -----------

        Total other income (expense)                                       (68,373)                    23,971
                            
                                           -----------                -----------

NET INCOME                                                             $ 3,233,459                $ 2,931,175
                                                                       ===========                ===========
</TABLE>

See notes to combined financial statements.


                                      -3-


<PAGE>


CLINICAL STUDIES LTD. AND CLINICAL MARKETING LTD.

COMBINED STATEMENTS OF STOCKHOLDERS' EQUITY
YEARS ENDED DECEMBER 31, 1996 AND 1995
- --------------------------------------------------------------------------------
<TABLE>
<CAPTION>

                                                              CSL               CML
                                                             No Par            No Par
                                                              Value             Value    Additional     Retained           Total
                                                    CSL      Common     CML    Common      Paid-in      Earnings       Stockholders'
                                                   Shares     Stock    Shares   Stock      Capital      (Deficit)          Equity
<S>                                                <C>       <C>       <C>     <C>       <C>            <C>           <C>
  
BALANCE, JANUARY 1, 1995                            100       $100       --   $     --    $120,000     $  (72,612)      $   47,488

  Issuance of common stock                           --         --      200        200          --             --              200

  Net income                                         --         --       --         --          --      2,931,175        2,931,175

  Dividends                                          --         --       --         --          --       (220,000)        (220,000)
                                                    ---        ---      ---   --------    --------     ----------        ---------

BALANCE, DECEMBER 31, 1995                          100        100      200        200     120,000      2,638,563        2,758,863
 
  Issuance of common stock (see Note 5)              --         --       35    627,640          --             --          627,640

  Net income                                         --         --       --         --          --      3,233,459        3,233,459

  Dividends                                          --         --       --         --          --     (1,731,592)      (1,731,592)
                                                    ---        ---      ---   --------    --------     ----------        ---------

BALANCE, DECEMBER 31, 1996                          100       $100      235   $627,840    $120,000     $4,140,430       $4,888,370
                                                    ===       ====      ===   ========    ========     ==========       ==========
</TABLE>

See notes to combined financial statements.


                                      -4-
<PAGE>


CLINICAL STUDIES LTD. AND CLINICAL MARKETING LTD.

COMBINED STATEMENTS OF CASH FLOWS
YEARS ENDED DECEMBER 31, 1996 AND 1995
- --------------------------------------------------------------------------------

<TABLE>
<CAPTION>

                                                                                 1996              1995
<S>                                                                          <C>               <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net income                                                                 $ 3,233,459       $ 2,931,175
  Adjustments to reconcile net income to net cash (used for) provided by
    operating activities:
      Depreciation and amortization                                              237,078            92,992
      Issuance of common stock as compensation                                   627,640                --
      Increase (decrease) in cash from:
        Contract receivables                                                  (3,687,441)       (1,995,853)
        Other assets                                                             (41,597)          (86,016)
        Accounts payable and accrued expenses                                    275,869         1,131,453
        Deferred revenue                                                        (757,956)        1,882,780
                                                                             -----------        -----------

          Net cash (used for) provided by operating activities                  (112,948)        3,956,531
                                                                             -----------        -----------

CASH FLOWS FROM INVESTING ACTIVITIES:
  Amount paid for acquired operations                                         (3,200,000)               --
  Purchase of equipment, net                                                    (210,356)         (211,400)
                                                                             -----------         -----------

          Net cash used for investing activities                              (3,410,356)         (211,400)
                                                                             -----------        -----------

CASH FLOWS FROM FINANCING ACTIVITIES:
  Borrowings under revolving bank line-of-credit, net                          3,132,300                --
  Payments on:
    Note payable                                                                  (2,750)           (1,144)
    Obligations under capital leases                                             (41,832)          (36,135)
  Dividends to stockholders                                                   (1,731,592)         (220,000)
  Issuance of common stock                                                  `         --               200
                                                                             -----------        -----------

          Net cash provided by (used for) financing activities                 1,356,126          (257,079)
                                                                             -----------        -----------

(DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS                              (2,167,178)        3,488,052

CASH AND CASH EQUIVALENTS, BEGINNING OF YEAR                                   3,595,454           107,402
                                                                             -----------        -----------

CASH AND CASH EQUIVALENTS, END OF YEAR                                       $ 1,428,276       $ 3,595,454
                                                                             ===========       ===========

SUPPLEMENTAL CASH FLOW INFORMATION-Interest payments                         $   121,082       $    18,000
                                                                             ===========       ===========

SUPPLEMENTAL NONCASH INVESTING AND FINANCING ACTIVITIES:
    CSL issued $3,950,000 of notes payable in 1996 in connection with
    acquisitions. CSL accrued $221,025 of contingent payments in 1996 in
    connection with acquisitions. CML issued 35 shares of common stock as
    compensation in 1996 at a value of $627,640
</TABLE>

See notes to combined financial statements.


                                      -5-


<PAGE>




CLINICAL STUDIES LTD. AND CLINICAL MARKETING LTD.

NOTES TO COMBINED FINANCIAL STATEMENTS
- --------------------------------------------------------------------------------


1.  NATURE OF BUSINESSES AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

    Nature of Businesses-Clinical Studies Ltd. ("CSL") performs clinical
    research studies sponsored by pharmaceutical companies and managed by
    contract research organizations. CSL enrolls patients, administers
    medications and submits data to sponsors for analysis. CSL operates in Rhode
    Island, Massachusetts, Florida, Arizona and Pennsylvania.

    Clinical Marketing Ltd. ("CML"), which began operations on September 1,
    1995, provides advertising and mixed media promotion services, primarily for
    CSL.

    CSL and CML have common owners.

    Principles of Combination-The combined financial statements include the
    accounts of CSL and CML (collectively the "Companies"). All significant
    intercompany accounts and transactions are eliminated in combination.

    Property and Equipment-Property and equipment are recorded at cost. Capital
    lease property and equipment is recorded at the lower of fair market value
    at the inception of the lease or the present value of the minimum lease
    payments required. Depreciation and amortization are provided using the
    straight-line method over the estimated useful lives of the related assets
    or, in the case of capital lease property and equipment and leasehold
    improvements, over the lesser of the life of the lease or the estimated
    useful life of the asset, as follows:

                                                                   Life

    Furniture and office equipment                                5 years
    Medical equipment                                             5 years
    Vehicles                                                      4 years

    Intangible Assets-Intangible assets consist primarily of goodwill,
    noncompete agreements and trained workforces acquired in the purchase of
    clinical site operations during 1996. The purchase price in excess of net
    assets acquired (goodwill) is amortized on a straight-line basis over twenty
    years. The Company evaluates the carrying value of goodwill based upon
    current and anticipated net income and undiscounted cash flows, and
    recognizes an impairment when it is probable that such estimated future net
    income and/or cash flows will be less than the carrying value of goodwill.
    Measurement of the amount of impairment, if any, is based upon the
    difference between carrying value and fair value. The costs allocated to
    noncompete agreements and the trained workforces are amortized on a
    straight-line basis over five and three years, respectively. Accumulated
    amortization amounted to approximately $114,000 for all intangible assets at
    December 31, 1996. There were no intangible assets recorded through 1995.


                                      -6-



<PAGE>




1.  NATURE OF BUSINESSES AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
    (CONTINUED)


    Income Taxes-The Companies, with the consent of their stockholders, have
    elected to be treated as S Corporations as provided under the Internal
    Revenue Code (the "Code"), whereby income taxes are the responsibility of
    the stockholders. Accordingly, the Companies' combined statements of
    operations do not include provisions for income taxes. Dividends are
    primarily intended to reimburse stockholders for income tax liabilities
    incurred.

    Revenue Recognition-CSL generates revenue based on contracts to perform
    clinical studies. Generally, these contracts specify the fees to be received
    as services are provided to patients enrolled in the studies. Revenues are
    recognized as patient visits are conducted and such services are provided.
    Costs related to the studies are expensed as incurred. Payments received
    prior to providing services are recorded as deferred revenue.

    CML generates revenue, primarily from CSL, based upon reimbursement of
    actual advertising and marketing expenses incurred plus a markup. Such
    revenue is eliminated in the combined financial statements.

    Cash and Cash Equivalents-Cash and cash equivalents include demand deposits
    held at financial institutions and short-term investments purchased with
    remaining maturities of three months or less.

    Use of Estimates-Preparation of the Companies' financial statements in
    conformity with generally accepted accounting principles requires management
    to make estimates and assumptions that affect the reported amounts of assets
    and liabilities and disclosure of contingent assets and liabilities at the
    balance sheet dates. The primary estimates underlying the Companies'
    combined financial statements include allowances for contract adjustments,
    deferred revenue, useful lives of long-lived assets and the amount of future
    earnings of acquisitions having contingent earnouts payable. Management
    bases its estimates on certain assumptions, which they believe are
    reasonable in the circumstances, and while actual results could differ from
    those estimates, management does not believe that changes in those
    assumptions in the near term would have a material effect on the Companies'
    combined financial position or results of operations.

    During 1996, the Companies revised their estimate of future employee
    benefits. Based on an analysis of actual employee activities, management
    revised their estimate of accrued nonvesting sick-pay benefits. The revision
    resulted in an increase in net income for the year ended December 31, 1996
    of approximately $190,000.

    Risks and Uncertainties-The Companies' businesses could be impacted by the
    failure of key customers, increasing competition in the pharmaceutical drug
    testing industry, federal and state legislation in the area of
    pharmaceutical drug testing and the departure of key trial investigators.
    Also, for a number of clinical trial programs, the Companies believe that
    industry protocols have resulted in final settlement of contract receivables
    being prolonged due to delays in the finalization of the testing program and
    data analysis. Changes in these areas could adversely impact the Companies'
    operations in the future.

                                      -7-


<PAGE>


1.  NATURE OF BUSINESSES AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
    (CONTINUED)

    Business and Credit Concentrations-The Companies are involved in the
    performance of clinical research trials for pharmaceutical companies and
    contract research organizations. Credit is granted without collateral to
    these customers. During the year ended December 31, 1996, revenue from three
    customers represented 21%, 12% and 11% of combined revenue. During the year
    ended December 31, 1995, revenue from one customer represented 35% of
    combined revenue. The Companies' largest ten customers accounted for 65% of
    total accounts receivable at December 31, 1996, of which two customer
    balances represented 14% and 13%. No other customer balances exceeded 10% of
    total accounts receivable at December 31, 1996.

    Accounting Pronouncements--Effective January 1, 1996, the Companies adopted
    Statement of Financial Accounting Standards ("SFAS") No. 121, "Accounting
    for the Impairment of Long-Lived Assets and for Long-Lived Assets to Be
    Disposed Of," and SFAS No. 123, "Accounting for Stock-Based Compensation."
    In accordance with the provisions of SFAS No. 123, the Companies elected to
    account for stock-based compensation under the provisions of APB 25. The
    adoption of SFAS Nos. 121 and 123 did not have a material impact on the
    Companies' combined financial statements.


2.  CONTRACT RECEIVABLES

    Contract receivables consisted of the following at December 31:

                                                         1996           1995

     Contracts in progress:
       Billed                                         $  678,445     $       --
       Unbilled                                        5,497,024      2,446,028
     Less: allowance for contract adjustments           (278,000)      (236,000)
                                                      ----------     -----------
                                                      $5,897,469     $2,210,028
                                                      ==========     ===========

    Substantially all of the Companies' contracts are subject to final
    adjustment upon close-out of the contracts with customers. Management
    estimates that such adjustments, if any, will not be materially different
    than the allowance recorded.

                                       -8-



<PAGE>



3.  LONG-TERM DEBT

    Long-term debt consisted of the following at December 31:

                                                         1996           1995

     Revolving bank line-of-credit                    $3,132,300     $       --
     Acquisition notes payable                         3,950,000             --
     Acquisition earnouts payable                        221,025             --
     Other note payable                                    8,203         10,953
     Capital lease obligations                            96,281        138,112
                                                      ----------     -----------
     Total                                             7,407,809        149,065

     Less current portion                                 90,069         44,581
                                                      ----------     -----------
     Long-term portion                                $7,317,740     $  104,484
                                                      ==========     ===========

    Revolving Bank Line-of-Credit-On October 1, 1996, CSL entered into a
    $5,000,000 revolving line-of-credit agreement with a bank. Interest, payable
    monthly, is computed at 1/4% above the bank's base rate (7.86% at 
    December 31, 1996). Such agreement is collateralized by a security interest 
    in all assets and the stock of both CSL and CML. The agreement expires on 
    September 30, 1999. In connection with this line-of-credit agreement, CSL is
    subject to certain restrictive loan covenants, which provide for, among
    other things, the maintenance of certain financial ratios. The most
    restrictive financial covenants are the requirement to combined net income
    of $100,000 per quarter and maintain a minimum net worth of $2.45 million at
    all times.

    Acquisition Notes Payable-In connection with the acquisitions during 1996
    (see Note 8), CSL issued uncollateralized promissory notes with maturity
    dates as follows:

       Amount                                                   Due Date

     $  250,000                                             January 1, 1998
        500,000                                             January 1, 1999
      1,000,000                                            November 2, 1999
      2,000,000                                             October 3, 2001
        100,000                                             August 31, 2001
        100,000                                             August 31, 2000

    Interest on all acquisition notes payable is paid quarterly in arrears at an
    annual interest rate of 7%.

    In the event of a public offering of its shares by the Companies, these
    notes are convertible into common stock at the option of the note holders.

                                       -9-


<PAGE>


3.  LONG-TERM DEBT (CONTINUED)

    Acquisition Earnouts Payable-In connection with one of the business
    acquisitions in 1996 (see Note 8), minimum earnout payments of $221,025 were
    established in the purchase agreement and have been accrued in the
    accompanying combined financial statements. These minimum payments are due
    as follows:

     Year                                                         Amount

     1997                                                       $ 40,000
     1998                                                         42,000
     1999                                                         44,100
     2000                                                         46,305
     2001                                                         48,620
                                                                --------
     Total                                                      $221,025
                                                                ========


    Other Note Payable-CSL has a note payable, collateralized by a vehicle, with
    a financing company. Such note requires monthly payments of approximately
    $300 for principal and interest through September 1999 and is collateralized
    by the vehicle.

    Scheduled maturities of the note payable at December 31, 1996 are as
    follows:

     Year                                                         Amount

     1997                                                         $2,978
     1998                                                          3,225
     1999                                                          2,000
                                                                  ------
     Total                                                        $8,203
                                                                  ======

                                      -10-



<PAGE>



3.  LONG-TERM DEBT (CONTINUED)

    Capital Leases-CSL leases certain equipment under capital leases. At
    December 31, 1996 and 1995 the cost of this equipment was $210,000.
    Accumulated amortization at December 31, 1996 and 1995 was approximately
    $126,000 and $84,000, respectively. The future minimum lease payments under
    the capital leases, together with the present value of the net minimum lease
    payments as of December 31, 1996, are as follows:

     Year                                                         Amount

     1997                                                       $ 55,943
     1998                                                         47,974
     1999                                                          2,811
     2000                                                          1,727
                                                                --------
     Net minimum lease payments                                  108,455

     Less amount representing interest                            12,174
                                                                --------
     Present value of net minimum lease payments                  96,281

     Less current portion                                         47,091
                                                                --------
     Long-term portion of obligation under capital lease        $ 49,190
                                                                ========
4.  EMPLOYEE BENEFIT PLAN

    The Companies participate in a profit-sharing plan (the "plan") for all
    employees which qualifies under Section 401(k) of the Code. The plan covers
    all employees who have completed six months of service and have atttained
    age twenty-one. The Companies allow eligible employees to contribute up to
    15% of their compensation and the Companies may match up to 20% of the
    employees' first 5% of covered compensation. The Companies may elect to make
    additional contributions at the discretion of the Board of Directors. The
    Companies made contributions to the plan of approximately $14,500 and
    $34,000 for the years ended December 31, 1996 and 1995, respectively.

5.  RELATED-PARTY TRANSACTIONS

    Included in operating expenses are discretionary management fees paid or
    accrued to the principal shareholders of CSL for management-related
    services. Approximately $987,000 and $1,700,000 of such management fees were
    incurred for the years ended December 31, 1996 and 1995, respectively, and
    are included in operating expenses.

    A key officer of CSL entered into an employment agreement with CSL, dated
    January 1995, which entitled him to additional compensation of 5.5% of
    annual net profits and, in the event of an IPO or sale of CSL, 5% of the
    proceeds from any such transaction.

                                      -11-



<PAGE>



5.  RELATED-PARTY TRANSACTIONS (CONTINUED)

    In June of 1996, the principal shareholders in CSL decided to formalize
    their arrangement with this officer as to his equity participation in the
    business. To effect this decision, the employee was granted a 15% equity
    interest in CML, which was merged into CSL effective January 1, 1997. Based
    on an independent appraisal, the Company valued the transaction at $627,640
    and recorded the amount as a 1996 operating expense. On January 1, 1997, the
    officer entered into a new employment agreement with CSL, with no provisions
    as to the sharing of profits, or proceeds, in the event of an IPO or sale of
    CSL.

6.  COMMITMENTS

    Operating Leases-The Companies lease office space under renewable operating
    leases expiring through the year 2004. Such operating leases require the
    payment of monthly rent and certain operating expenses.

    As of December 31, 1996, the lease agreements require approximate annual
    lease payments as follows:

    Year                                                          Amount

    1997                                                      $1,113,000
    1998                                                       1,203,000
    1999                                                       1,153,000
    2000                                                         827,000
    2001                                                         472,000
    Thereafter                                                   318,000
                                                              ----------
    Total                                                     $5,086,000
                                                              ==========

    Total rent expense was approximately $820,000 and $598,000 for the years
    ended December 31, 1996 and 1995, respectively.

7.  PROFIT-SHARING AGREEMENT

    CSL has a profit-sharing agreement with a consultant to the Company. Such
    agreement provides for payments to be made to the individual based on 10% of
    income of the sites in existence at June 15, 1996, before taxes and certain
    management fees paid to officers of CSL, for the year. Amounts charged to
    expenses related to such agreements totaled approximately $314,000 and
    $433,000 for 1996 and 1995, respectively (see Note 10).

    Under the same agreement, in the event that a majority interest in the
    common stock of CSL is sold by CSL's stockholders, CSL is obligated to pay
    to the former consultant an amount up to a combined total of 10% of the
    consideration received by the stockholders.

                                      -12-



<PAGE>


8.  ACQUISITONS

    All acquisitions have been accounted for using the purchase method of
    accounting, and operations of the acquired businesses have been included in
    the accompanying combined financial statements from their respective dates
    of acquisition. The excess of purchase price over the fair value of the net
    assets acquired is allocated to goodwill, noncompete covenants and trained
    workforces. Most purchase agreements provide for contingent payments based
    on targeted annual income of the acquired business, for a period of up to
    five years. Any such future payments are generally capitalized as goodwill
    when paid.

    On August 31, 1996, CSL acquired the business and certain assets of a single
    site clinical research company in Sarasota, Florida for $300,000 plus
    contingent consideration based on profitability measures over the next five
    years. The purchase price consisted of $100,000 of cash and the issuance of
    two subordinated promissory notes of $100,000 each. The contingent payments
    will equal 15% of the increase in adjusted income before tax, of the
    acquired business, over the prior year's amount. In no event shall the
    contingent payments be less than $221,025. The full amount of the minimum
    payments was accrued for at the date of the acquisition.


    On October 4, 1996, CSL acquired the business and certain assets of a
    multi-site clinical research company in Pennsylvania for $6,850,000 plus
    contingent consideration based on profitability measures over the next five
    years. The purchase price consisted of $3,100,000 of cash and the issuance
    of two subordinated promissory notes of $2,000,000 and $1,750,000,
    respectively. The contingent payments will equal 15% of the excess of
    adjusted income before tax over $2,000,000 per year for five years and, in
    the case of an initial public offering of the Companies' stock, $750,000 of
    such stock.

    The cost of the acquisitions was preliminarily allocated on the basis of the
    estimated fair value of the assets acquired and the liabilities assumed.
    This allocation resulted in goodwill of $6,966,000, noncompete agreements of
    $355,000 and trained workforces of $50,000.

9.  STOCK OPTIONS

    In 1996, the Board of Directors of CSL (the "Board") adopted the 1996 Equity
    Incentive Plan, under which incentive and nonqualified options to purchase
    up to 10 shares of CSL's common stock may be granted over a ten-year period
    to directors, officers, employees and consultants. All option grants, prices
    and vesting periods are determined by the Board. Incentive stock options may
    be granted at a price not less than fair market value on the date of grant,
    as determined by the Board.


                                      -13-



<PAGE>




9.  STOCK OPTIONS (CONTINUED)

    A summary of stock option activity is as follows:

                                                                  Weighted
                                                 Number            Average
                                                   of             Exercise
                                                Options            Price

    Outstanding at December 31, 1995               --              $  --

    Granted                                       2.31              147,597
                                                --------           --------
    Outstanding at December 31, 1996              2.31              147,597
                                                --------           --------
    Exercisable at December 31, 1996            $0.634             $147,597
                                                ========           ========

    The following table sets forth information regarding options outstanding at
    December 31, 1996:

<TABLE>
<CAPTION>
                                                                   Options Exercisable
                                                               -------------------------
                 Options Outstanding                                           Weighted
- ---------------------------------------------------------                       Average
                                  Weighted      Weighted                       Exercise
                                   Average       Average        Number         Price for
Number of          Exercise       Remaining      Exercise      Currently       Currently
Options             Price           Life          Price       Exercisable     Exercisable
  <S>              <C>            <C>           <C>              <C>            <C>
  2.31             $147,597       9 years       $147,597         0.634          $147,597
</TABLE>

    CSL uses the intrinsic value method to measure compensation expense
    associated with grants of stock options to employees. Because the option
    exercise price significantly exceeds the estimated fair value of the
    Company's stock at the grant date, the weighted average fair value of
    options granted in 1996 was $0. Accordingly, had CSL used the fair value
    method to measure compensation, reported net income (before distributions)
    would not have changed for 1996.

    The fair value of options on their grant date was measured using the
    Black-Scholes option pricing model. Key assumptions used to apply this
    pricing model are as follows:

                                                                         1996
    Risk-free interest rate                                              5.5%
    Expected life of option grants                                     10 years
    Expected volatility of underlying stock                               --
    Expected dividend payment rate, as a percentage of the stock
      price on the date of grant                                          --

    The option pricing model used was designed to value readily tradeable stock
    options with relatively short lives. The options granted to employees are
    not tradeable and have contractual lives of up to ten years. However,
    management believes that the assumptions used to value the options and the
    model applied yield a reasonable estimate of the fair value of the grants
    made under the circumstances.


                                      -14-


<PAGE>


10. SUBSEQUENT EVENTS

    On January 1, 1997, CSL and CML merged operations into one Delaware
    Subchapter S Corporation, also named Clinical Studies Ltd. Each share of CSL
    and CML was converted to 5,324.53 shares and 1,562.27 shares, respectively,
    of the new entity.

    On March 12, 1997, the shareholders of CSL signed a letter of intent to
    exchange the stock of CSL for stock of PhyMatrix Corp. ("PhyMatrix"), a
    publicly traded company. The purchase price will be determined based on the
    average five-day trading price of the PhyMatrix stock prior to closing, less
    any closing adjustments. The transaction is subject to the approval and the
    satisfaction of certain conditions.

    On April 9, 1997, CSL acquired the business and certain assets of
    Neuropsychiatric Services of Greater Washington, Inc. for $725,000 plus
    contingent consideration based on revenue and profitability measures over
    the next five years. The contingent payments will equal 10% of the excess
    gross revenue, as defined, provided the gross operating margins of the
    acquired business exceed 30%.

    The Company is in negotiations to settle its obligations to a consultant
    under a profit-sharing agreement (see Note 7). On April 23, 1997, CSL
    received a letter of understanding from the consultant proposing to settle
    the obligations under his profit-sharing agreement. Under the terms of the
    proposed settlement, the consultant would receive $2.5 million in cash and a
    promissory note for approximately $2,000,000.


                                   * * * * * *


                                      -15-

<PAGE>



CLINICAL STUDIES, LTD.
FINANCIAL STATEMENTS AND
SUPPLEMENTAL SCHEDULE
FOR THE YEAR ENDED
DECEMBER 31, 1994 AND 
INDEPENDENT AUDITORS' REPORT



<PAGE>

                      Sansiveri, Kimball & McNamee, L.L.P.
                      ------------------------------------
                          CERTIFIED PUBLIC ACCOUNTANTS
                              BUSINESS CONSULTANTS

                                                          Michael A. DeCataldo
                                                          M. Douglas Fay
                                                          Joseph H. Kimball, Jr.
                                                          Stephen P. Massed
                                                          John J. McNamee
                                                          John L. Pucci
                                                          Jerry A. Sansiveri




                          INDEPENDENT AUDITORS' REPORT

To the Stockholders of 
Clinical Studies Ltd.:

We have audited the accompanying balance sheet of Clinical Studies Ltd. as of
December 31, 1994, and the related statements of operations and deficit and cash
flows for the year then ended. This financial statement is the responsibility of
the Company's management. Our responsibility is to express an opinion on this
financial statement based on our audit.

We conducted our audit in accordance with generally accepted auditing standards.
Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether the financial statement is free of material
misstatement. An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statement. An audit also includes
assessing the accounting principles used and significant estimates made by
management, as well as evaluating the overall financial statement presentation.
We believe that our audit provides a reasonable basis for our opinion. 

In our opinion, the financial statement referred to above presents fairly, in
all material respects, the financial position of Clinical Studies Ltd. as of
December 31, 1994, and the results of its operations and its cash flows for the
year then ended in conformity with generally accepted accounting principles. 

Our audit was made for the purpose of forming an opinion on the basic
consolidated financial statements taken as a whole. The accompanying
supplemental schedule is presented for the purpose of additional analysis and is
not a required part of the basic consolidated financial statements. Such
information has been subjected to the auditing procedures applied in the audits
of the basic consolidated financial statements and, in our opinion, is fairly
stated in all material respects in relation to the basic consolidated financial
statements taken as a whole.



/s/ Sansiveri, Kimball & McNamee, L.L.P.

April 14, 1997 (except for Note 7, 
which is dated April 23, 1997)






55 Dorrance Street, Providence, RI 02903-2220 o Providence o Newport o Westerly
           401/331-0500, Fax 401/331-9040, E-Mail: [email protected]

        Member of Division for CPA Firms/AICPA, SEC Practice Section and
                      Associated Regional Accounting Firms.


<PAGE>
                             CLINICAL STUDIES LTD.

                                 BALANCE SHEET
                               DECEMBER 31, 1994
- --------------------------------------------------------------------------------

                                    -ASSETS-

- --------------------------------------------------------------------------------

CURRENT ASSETS (Notes 2 and 5):
  Cash and cash equivalents  ................................   $ 107,402
  Accounts receivable-contracts  ............................     214,175
                                                                ---------
      Total current assets  .................................     321,577
                                                                ---------

PROPERTY AND EQUIPMENT - At cost (Note 2):
  Furniture and office equipment  ...........................      87,379
  Medical equipment  ........................................      27,612
  Leasehold improvements  ...................................       4,800
                                                                ---------
      Total  ................................................     119,791
  Less accumulated depreciation and amortization  ...........      42,542
                                                                ---------
    Property and equipment, net  ............................      77,249

LEASED PROPERTY UNDER CAPITAL LEASE - Less accumulated
  amortization of $43,134 (Notes 2 and 6)  ..................     155,935
OTHER ASSET - Deposits  .....................................      13,933
                                                                ---------

      TOTAL  ................................................   $ 568,694
                                                                =========



- --------------------------------------------------------------------------------

                     -LIABILITIES AND STOCKHOLDERS' EQUITY-

- --------------------------------------------------------------------------------

CURRENT LIABILITIES:
  Current portion of obligation under capital lease 
    (Note 4)  ...............................................   $  35,460
  Accounts payable - trade  .................................      86,420
  Deferred revenue  .........................................      57,400
  Accrued liabilities:
    Payroll and payroll taxes  ..............................     118,284
    Consulting fees  ........................................      95,929
                                                                ---------
      Total current liabilities  ............................     393,493

OBLIGATION UNDER CAPITAL LEASE - Less current portion
  (Note 4)  .................................................     127,713
                                                                ---------

COMMITMENTS (Note 4)

STOCKHOLDERS' EQUITY:
  Common stock - no par value; authorized 1,000 shares;
    issued and outstanding, 100 shares  ....................          100
  Additional paid in capital (Notes 4 and 6)  ..............      120,000
  Deficit  .................................................      (72,612)
                                                                ---------
      Total stockholders' equity  ..........................       47,488
                                                                ---------
      TOTAL  ...............................................     $568,694
                                                                =========



                       See notes to financial statement.

<PAGE>

- --------------------------------------------------------------------------------


                              CLINICAL STUDIES LTD.

                  STATEMENT OF OPERATIONS AND RETAINED DEFICIT
                      FOR THE YEAR ENDED DECEMBER 31, 1994
- --------------------------------------------------------------------------------


- --------------------------------------------------------------------------------

REVENUE (Note 5)  ................................................  $ 4,921,285
OPERATING EXPENSES  ..............................................    5,019,282
                                                                    -----------
LOSS FROM OPERATIONS  ............................................      (97,997)
                                                                    -----------

OTHER INCOME (DEDUCTION):
  Interest income  ...............................................          461
  Interest expense  ..............................................       (1,166)
                                                                    -----------
    Other deduction, net  ........................................         (705)
                                                                    -----------

NET LOSS  .........................................................     (98,702)
RETAINED EARNINGS, JANUARY 1, 1994  ...............................      26,090
                                                                    -----------
DEFICIT, DECEMBER 31, 1994  .......................................   $ (72,612)
                                                                    ===========

                        See notes to financial statement.


- --------------------------------------------------------------------------------
<PAGE>


                             CLINICAL STUDIES LTD.

                            STATEMENT OF CASH FLOWS
                      FOR THE YEAR ENDED DECEMBER 31, 1994
- --------------------------------------------------------------------------------

RECONCILIATION OF CASH FLOWS FROM OPERATING
ACTIVITIES:
  Net loss ........................................................   $ (98,702)
  Noncash expenses and revenue included in net income -
    depreciation and amortization .................................      58,851
  Changes in operating assets and liabilities:
    Accounts receivable ...........................................     (29,427)
    Accounts payable and accrued expenses .........................     209,870
    Deferred revenue ..............................................    (221,065)
                                                                     ----------
NET CASH USED BY OPERATING ACTIVITIES ............................      (80,473)
                                                                     ----------
CASH FLOWS FROM INVESTING ACTIVITIES:
  Purchases of equipment .........................................      (73,916)
  Payments received on notes receivable - shareholder  ...........       70,000
  Payments received on notes receivable - other  .................       90,000
                                                                     ----------
NET CASH PROVIDED BY INVESTING ACTIVITIES  .......................       86,084
                                                                     ----------
CASH FLOWS FROM FINANCING ACTIVITIES:
  Payments on obligations under capital leases  ..................      (35,896)
  Payments on note payable - stockholder  ........................      (21,000)
  Payments on note payable - related party  ......................      (39,780)
                                                                     ----------
NET CASH USED BY FINANCING ACTIVITIES  ...........................      (96,676)
                                                                     ----------
DECREASE IN CASH AND CASH EQUIVALENTS  ...........................      (91,065)

CASH AND CASH EQUIVALENTS, JANUARY 1, 1994  ......................      198,467
                                                                     ----------
CASH AND CASH EQUIVALENTS, DECEMBER 31, 1994  ....................    $ 107,402
                                                                     ==========

                       See notes to financial statements.


<PAGE>





                              CLINICAL STUDIES LTD.

                          NOTES TO FINANCIAL STATEMENT

                                 ---------------


1. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

     Operations 
     ----------

     Clinical Studies Ltd. (the Company) performs clinical research studies
     sponsored by pharmaceutical companies and clinical research organizations
     (sponsors). The Company enrolls patients, administers medications and
     submits data to the sponsors for analysis. The Company operates in Rhode
     Island, Massachusetts, Florida, Arizona, and Pennsylvania.

     Cash and Cash Equivalents
     -------------------------

     Cash and cash equivalents include demand deposits held at financial
     institutions and short-term investments with original maturities of less
     than three months. 

     Accounts Receivable - Contracts
     -------------------------------

     Accounts receivable - contracts represents amounts owed to the Company by
     sponsors for work performed in accordance with contracts with such
     sponsors. 

     Deferred Revenue
     ----------------

     Deferred revenue represents payments received in advance by the Company for
     performing work in accordance with contracts with sponsors.

     Revenue Recognition
     -------------------

     The company generates revenue based on contracts it enters into to perform
     clinical studies. Generally these contracts specify a fee to be received
     for patients enrolled in the study. Revenues are recognized as patient
     visits are conducted. Costs related to the studies are generally expensed
     as incurred. Payments received in excess of revenue recognized are reported
     as deferred revenue.



<PAGE>



     Depreciation and Amortization

     Depreciation and amortization of equipment, leasehold improvements, and
     leased property under capital leases are computed using the straight-line
     method over 5 to 7 years, 31-1/2 years, and 5 years, respectively, for
     financial reporting purposes. Accelerated methods of depreciation and
     amortization are used for income tax purposes.

     Income Taxes
     ------------

     The Company, with the consent of its stockholders, has elected to be
     treated as an S Corporation as provided under the Internal Revenue Code,
     whereby income taxes are the liability of the stockholders. Accordingly,
     the accompanying balance sheet does not include a liability for Federal or
     state taxes and the statement of operations and retained deficit does not
     include a provision for such income taxes. 

     Employee Benefit Plans
     ----------------------

     As of January 1, 1995, the Company began participating in a profit sharing
     plan for all employees. Such plan qualifies under section 401(k) of the
     Internal Revenue Code. The profit sharing plan covers all employees who
     have completed six months of service and have attained age twenty-one. The
     Company allows eligible employees to contribute up to 15% of their
     compensation and the Company may match up to 20% of the employee's
     contribution for the first 5% of covered compensation. In addition, the
     Company may elect to make additional contributions at the discretion of the
     Board of Directors. 

     Estimates
     ---------

     Preparation of financial statements in conformity with generally accepted
     accounting principles requires management to make estimates and assumptions
     that affect the reported amounts of assets and liabilities and disclosure
     of contingent assets and liabilities at the date of the balance sheet.
     Actual results could differ from those estimates.

     Advertising
     -----------

     The Company expenses its advertising costs in the period in which such
     costs are incurred. 


2. SHORT-TERM FINANCING ARRANGEMENT 

     The Company has a line-of-credit agreement with a bank. The line-of-credit
     has maximum available borrowings of $175,000 and requires monthly payment
     of interest at the bank's prime rate plus 1%. Such note requires a 5%
     compensating cash balance and is 



                                       2


<PAGE>





     collateralized by all business assets and the personal guarantees of a
     stockholder and an officer of the Company. As of December 31, 1994, the
     Company had no outstanding borrowings on such line of credit.
 
     On October 1, 1996, the Company entered into a $5,000,000 revolving
     line-of-credit agreement with a bank. Interest, payable monthly, is
     computed at .25% above the bank's base rate. Such agreement is
     collateralized by a security interest in all assets and the stock of
     Clinical Studies Ltd. and Clinical Marketing Ltd., a company related
     through common ownership. The agreement expires on September 30, 1999. In
     connection with this line-of-credit agreement, Clinical Studies Ltd. is
     subject to certain restrictive covenants, which provide for, among other
     things, the maintenance of certain financial ratios. The most restrictive
     financial covenants are the requirement to earn combined net income of
     $100,000 per quarter and maintain a net worth of $2.45 million at all
     times. 

3. RELATED PARTY TRANSACTIONS 

     Management fees consist of amounts paid for management related services to
     a stockholder and an officer of the Company who is related to the
     stockholders. Approximately $802,000 of such management fees were incurred
     for the year ended December 31, 1994. 

4. COMMITMENTS 

     Operating Leases
     ----------------

     The Company leases office space under various operating leases that expire
     at varying dates through the year 1999. Such operating leases require the
     payment of monthly rent and certain operating expenses.

     As of December 31, 1994, the lease agreements require approximate annual
     base rental payments as follows:

                                Year                          Amount
                               ------                         ------
           1995    ........................................  $161,000
           1996    ........................................   165,000
           1997    ........................................   136,000
           1998    ........................................   143,000
           1999    ........................................   111,000


     Rent expense for the year ended December 31, 1994 was approximately
     $305,000.



                                       3

<PAGE>





     Capital Lease
     -------------

     The Company leases certain equipment under a capital lease. The future
     minimum lease payments under the capital lease, together with the present
     value of the net minimum lease payments as of December 31, 1994 are as
     follows:

                                    Year                         Amount
                                    ----                         ------
           1995  ............................................   $53,133
           1996  ............................................    53,133
           1997  ............................................    53,133
           1998  ............................................    45,163
                                                                -------
           Net minimum lease payments  ......................   204,562
           Less amount representing interest  ...............    41,389
                                                                -------
           Present value of net minimum lease payments  .....   163,173
           Less current portion  ............................    35,460
                                                                -------
           Long-term portion of obligation under 
             capital lease  .................................  $127,713
                                                               ========

     Consulting Agreement
     --------------------

     The Company has an agreement with a consultant whereby for consideration
     paid in the amount of $120,000, the consultant is to receive up to 10% of
     income, before taxes and certain management fees paid to officer of the
     Company for the year. The payment is limited to that percentage of net
     income (as specified in the agreement) of sites in existence on June 15,
     1996. In the event that a majority interest in the Company is sold, such
     consultant is entitled up to 10% of the proceeds of the sale.

     Contingent Obligations
     ----------------------

     As of December 31, 1995, in the event that a majority interest in the
     common stock of Clinical Studies Ltd. is sold by the Company's
     stockholders, Clinical Studies Ltd. is obligated to pay to one of its
     officers and another party an amount up to a combined total of 15% of the
     consideration received by the stockholders. Alternatively, in the event
     that Clinical Studies Ltd. registers a class of its equity securities under
     the Securities Act of 1933, the officer of Clinical Studies Ltd. will be
     entitled to receive 5% of such class of equity securities.


5. CONCENTRATIONS OF CREDIT RISK

     Financial instruments which potentially subject the Company to
     concentrations of credit risk consist principally of cash in the bank in
     excess of FDIC insurance limits and 



                                       4

<PAGE>


     accounts receivable - contracts. As of December 31, 1994, the Company has
     approximately $69,000 in the bank in excess of FDIC insurance limits. These
     funds are on deposit with a high credit quality financial institution.
     Management believes that credit risk with respect to accounts receivable -
     contracts is limited due to the large number of customers comprising the
     Company's customer base and the credit worthiness of its customer base. The
     Company has not experienced any significant credit losses.
 
     At December 31, 1994, two customers accounted for 100% of accounts
     receivable - contracts.

     Contract revenue associated with three pharmaceutical companies accounted
     for approximately 59% of revenue for the year ended December 31, 1994.

6.  SUPPLEMENTAL CASH FLOW INFORMATION

     The accompanying statement of cash flows excludes the effect of the
     following noncash transactions:

     o During 1994, the lease of certain equipment resulted in an asset and
       obligation under capital lease of approximately $199,000;

     o During 1994, the Company entered into an agreement whereby a consultant
       receives 10% of the net profits of the company in exchange for
       consideration of $120,000. This consideration was an amount of a 
       liability which was due to such consultant. The effect of this 
       transaction was an increase of additional paid in capital and a reduction
       of deferred revenue of $120,000.

7.  SUBSEQUENT EVENTS


     Clinical Marketing Ltd., a company owned by a shareholder and a relative of
     another shareholder of Clinical Studies, Ltd., began operations on
     September 1, 1995 and provides advertising and mixed media promotion
     services for the Company.
  
     On August 31, 1996, the Company acquired the business and certain assets of
     a single site clinical research company in Sarasota, Florida for $300,000
     plus contingent consideration based on profitability measures over the next
     five years. The contingent payments will equal 15% of the increase in
     adjusted income before tax, of the acquired business, over the prior year's
     amount. In no event shall the contingent payments be less than $221,025.




                                       5



<PAGE>





     On October 4, 1996, the Company acquired the business and certain assets of
     a multi-site clinical research company in Pennsylvania for approximately
     $6,850,000 plus contingent consideration based on profitability measures
     over the next five years. The contingent payments will equal 15% of the
     excess of adjusted income before tax over $2,000,000.

     On January 1, 1997, the Company and Clinical Marketing Ltd. merged
     operations into one Delaware Subchapter S Corporation, also named Clinical
     Studies Ltd. Each share of the Company and Clinical Marketing Ltd. was
     converted to 5,324.53 shares and 1,562.27 shares, respectively, of the new
     entity.

     On March 12, 1997, the shareholders of the Company signed a letter of
     intent to sell Clinical Studies Ltd. to PhyMatrix Corp. (PhyMatrix), a
     publicly traded company. The purchase price will be determined based on the
     average five-day trading price of the PhyMatrix stock prior to closing,
     less any closing adjustments. The transaction is subject to the approval
     and the satisfaction of certain conditions.

     On April 9, 1997, the Company acquired the business and certain assets of
     Neuropsychiatric Services of Greater Washington, Inc. for $725,000 plus
     contingent consideration based on revenue and profitability measures over
     the next five years. The contingent payments will equal 10% of the excess
     gross revenue, as defined, provided the gross operating margins of the
     acquired business exceed 30%.

     On April 23, 1997, the Company received a letter of understanding from a
     former consultant (see Note 4) to settle the obligations under his
     profit-sharing agreement. Under the terms of the proposed settlement, the
     former consultant will receive $2.5 million in cash and a promissory note
     for approximately $2,000,000. 


                                       6


<PAGE>





                                                                        Schedule
                                                                        --------

                              CLINICAL STUDIES LTD.
                         SCHEDULE OF OPERATING EXPENSES
                      FOR THE YEAR ENDED DECEMBER 31, 1994

- --------------------------------------------------------------------------------

Payroll ..................................................     $1,548,800
Management fees ..........................................        802,000
Consulting fees ..........................................        742,280
Advertising ..............................................        482,315
Rent .....................................................        305,647
Office expense ...........................................        179,303
Payroll taxes ............................................        131,598
Employee benefits ........................................        133,354
Travel and entertainment .................................         95,461
Telephone ................................................         96,598
Insurance ................................................         29,159
Professional fees ........................................         73,467
Depreciation and amortization ............................         58,851
Patient travel ...........................................         97,572
Postage ..................................................         30,425
Utilities ................................................         27,625
Supplies .................................................         98,742
Dues and subscriptions ...................................          3,409
Taxes ....................................................         14,247
Administrative ...........................................         42,500
Repairs and maintenance ..................................          3,867
Donations ................................................          1,905
Education ................................................          3,808
Licenses and fees ........................................          5,592
Miscellaneous ............................................         10,757
                                                               -----------
Total ....................................................     $5,019,282
                                                               ==========






<PAGE>
               UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION


The merger is to be accounted for in accordance with the pooling of interests
method of accounting pursuant to APB Opinion No. 16. The pooling of interests
method of accounting assumes that PhyMatrix Corp. ("PhyMatrix") and Clinical
Studies, Ltd. and Clinical Marketing Ltd. (collectively "CSL") have been merged
since their inception, and the historical consolidated financial statements for
periods prior to consummation of the merger are restated as though the companies
have been combined since January 1, 1994. Accordingly, the accompanying
Unaudited Pro Forma Combined Financial Information gives effect to the
transaction in accordance with pooling of interests accounting.

The following Unaudited Pro Forma Combined Statements of Operations for the six
months ended July 31, 1997 and the years ended December 31, 1994 and 1995 and
January 31, 1997 have been prepared to reflect the merger with CSL as if it had
been completed on January 1, 1994. Adjustments have been made as described to
record income tax expense on CSL's historical Statements of Operations. The
Unaudited Pro Forma Combined Balance Sheet at July 31, 1997 gives effect to the
merger with CSL as if such merger had occurred on July 31, 1997.

The Unaudited Pro Forma Combined Financial Information has been prepared based
on the audited and unaudited historical financial statements of PhyMatrix and
CSL, which statements are included herein. The Unaudited Pro Forma Combined
Financial Information is not indicative of the results that would have occurred
if the acquisition of CSL had occurred on the dates indicated or which may be
realized in the future.

The Unaudited Pro Forma Combined Financial Information should be read in
conjunction with (i) PhyMatrix' consolidated historical financial statements and
related notes contained in the annual, quarterly and other reports filed by
PhyMatrix with the Securities and Exchange Commission, (ii) CSL's audited
historical combined financial statements for the years ended December 31, 1994,
1995 and 1996, and (iii) CSL's unaudited historical combined financial
statements for the six months ended July 31, 1997.

The Unaudited Pro Forma Combined Financial Information has been prepared in
accordance with generally accepted accounting principles. These principles
require management to make extensive use of estimates and assumptions that
affect the reported amounts of assets and liabilities and disclosure of
contingent assets and liabilities at the date of the consolidated financial
statements and the reported amounts of revenues and expenses during the
reporting period. Actual results could differ from those estimates. The
Unaudited Pro Forma Combined Statements of Operations are not necessarily
indicative of future operating results.


<PAGE>
                        PRO FORMA COMBINED BALANCE SHEETS
                               As of July 31, 1997
                                   (Unaudited)
<TABLE>
<CAPTION>

                                                          PhyMatrix        Clinical                                  Pro Forma
                                                            Corp.           Studies             Adjustments          Combined
                                                            -----           -------             -----------          --------
<S>                                                     <C>               <C>               <C>                   <C>
 ASSETS                                                 
 Current assets                                         
         Cash and cash equivalents                      $ 58,638,326      $   744,772       $  (10,150,000)(A)    $  49,233,098
         Receivables:                                    
                 Accounts receivable, net of allowances   48,949,768        7,631,640                                56,581,408
                 Other receivables                         3,440,009                -                                 3,440,009
                 Notes receivable                          2,364,537                -                                 2,364,537
          Prepaid expenses and other current assets        5,538,993                -                   -             5,538,993
                                                           ---------         ---------          ---------           ----------- 
                         Total current assets            118,931,633        8,376,412          (10,150,000)         117,158,045
                                                         
                                                         
 Property, plant and equipment, net                       40,214,895          631,317                                40,846,212
 Notes receivable                                          7,884,700                -                                 7,884,700
 Goodwill, net                                            84,355,699        7,708,913                                92,064,612
 Management service agreements, net                       56,078,028                -                                56,078,028
 Investment in affiliates                                  3,517,934                -                                 3,517,934
 Other assets (including restricted cash)                 12,400,247          200,293                    -           12,600,540
                                                           ---------         ---------          ---------           -----------
                                                        $323,383,136      $16,916,935       $   (10,150,000)      $ 330,150,071
                         Total assets                      =========       ===========         ============         ===========
                                                         
 LIABILITIES AND SHAREHOLDERS' EQUITY       
 Current liabilities                       

         Current portion of debt and capital leases     $  3,522,190      $    87,091                             $   3,609,281
         Accounts payable                                  7,449,454          664,297                                 8,113,751
         Accrued compensation                              1,002,940          417,882                                 1,420,822
         Accrued and other current liabilities            12,353,045        1,603,125              478,000 (B)       14,434,170
                                                           ---------         ---------          ---------           -----------  

                         Total current liabilities        24,327,629        2,772,395              478,000           27,578,024 
                                                         
                                                         
 Long-term debt and capital leases, less current         
 portion                                                   7,863,224        9,019,191                                16,882,415
 Convertible subordinated debentures                     100,000,000                -                               100,000,000
 Other long term liabilities                              11,759,706                -                                11,759,706
 Deferred tax liability                                            -                                     -                      
 Minority interest                                         1,854,455                -                    -            1,854,455
                                                           ---------         ---------          ---------           -----------  
                         Total liabilities               145,805,014       11,791,586              478,000          158,074,600
                                                         
                                                         
 Commitments and contingencies                           
 Shareholders' equity:                                   
         Common stock                                        239,269          627,940                                   867,209
         Additional paid in capital                      169,160,700          120,000                               169,280,700
         Retained earnings                                 8,178,153        4,377,409          (10,628,000)(A)(B)     1,927,562
                                                           ---------         ---------          ---------           -----------   
                         Total shareholders' equity      177,578,122        5,125,349          (10,628,000)         172,075,471
                                                           ---------         ---------          ---------           -----------   
  Total liabilities and shareholders' equity            $323,383,136      $16,916,935       $  (10,150,000)        $ 330,150,071
                                                         ============     ===========         ============          ===========
                                                         
</TABLE>
<PAGE>
                   PRO FORMA COMBINED STATEMENTS OF OPERATIONS

                         Six Months Ended July 31, 1997
                                   (Unaudited)



<TABLE>
<CAPTION>
                                                                             Clinical                                Pro Forma
                                                           PhyMatrix          Studies             Adjustments         Combined
                                                           ---------          -------             -----------         ---------
                                                              (C)                 (D)

<S>                                                       <C>                <C>                  <C>              <C>
Net revenues from services                               $ 69,961,529       $13,128,176                           $ 83,089,705
Net revenue from management service agreements             75,685,223                 -                  -          75,685,223
                                                          -----------       -----------          -----------       -------------
                Total revenue                             145,646,752        13,128,176                  -         158,774,928
                                                          -----------       -----------          -----------       -------------
                                                         
                                                         
Operating costs and administrative expenses:             
        Cost of affiliated physician management services   33,534,991                 -                             33,534,991
        Salaries, wages and benefits                       33,811,558         5,320,912                             39,132,470
        Professional fees                                   3,140,177         1,114,546                              4,254,723
        Supplies                                           19,719,512           180,932                             19,900,444
        Utilities                                           1,877,154           230,295                              2,107,449
        Depreciation and amortization                       4,533,310           323,684                              4,856,994
        Rent                                                6,521,290           635,456                              7,156,746
        Other                                              28,797,025         4,401,509                  -          33,198,534 (E)
                Total operating costs and                 -----------       -----------          -----------       -------------
                       administrative expenses            131,935,017        12,207,334                  -         144,142,351
                                                          -----------       -----------          -----------       -------------
        Operating income                                   13,711,735           920,842                  -          14,632,577
                                                                                                                             -
                                                         
Interest expense, net                                       1,382,600           291,363                              1,673,963
Income from investment in affiliates                         (412,985)                -                  -            (412,985)
                                                          -----------       -----------          -----------       -------------
                                                         
Income before provision for income taxes                   12,742,120           629,479                  -          13,371,599
Income tax expense                                          4,545,904                 -            251,792 (F)       4,797,696
                                                          -----------       -----------          -----------       -------------
                                                         
Net income (loss)                                        $  8,196,216        $  629,479          $(251,792)        $ 8,573,903
                                                          ===========       ===========          ===========       =============
                    
Net income per weighted average share                    $       0.34                                              $      0.29
                                                          -----------                                              ------------
Weighted average number of shares outstanding (I)          23,863,289                                               29,108,722
                                                           ===========                                              =============
</TABLE>
        
<PAGE>
                   PRO FORMA COMBINED STATEMENTS OF OPERATIONS

                                   (Unaudited)


<TABLE>
<CAPTION>
                                                                                Clinical            
                                                              PhyMatrix         Studies             Adjustments
                                                              Year Ended        Year Ended          Year Ended
                                                              January 31,       December 31,        January 31,      Combined
                                                                 1997              1996                1997          Pro Forma
                                                              ---------           -------           -----------      ---------
                                                                (C)                (D)
<S>                                                          <C>              <C>                <C>                <C>           
 Net revenues from services                                  $ 99,773,277     $ 18,040,124                       $  117,813,401
 Net revenue from management service agreements                90,187,458                -              -            90,187,458
                                                               ----------       ----------        ----------         ----------
                 Total revenue                                189,960,735       18,040,124              -           208,000,859
                                                               ----------       ----------        ----------         ----------
                                                            
 Operating costs and administrative expenses:               
         Cost of affiliated physician management services      42,245,211                -                           42,245,211
         Salaries, wages and benefits                          52,313,062        6,037,786                           58,350,848 (E)
         Professional fees                                      4,119,161        3,202,688                            7,321,849 (E)
         Supplies                                              26,939,628          263,277                           27,202,905
         Utilities                                              2,562,328          306,156                            2,868,484
         Depreciation and amortization                          7,144,588          237,875                            7,382,463
         Rent                                                   7,653,298          865,514                            8,518,812
         Provision for bad debt                                 4,607,888                -                            4,607,888
         Other                                                 22,534,066        3,824,996              -            26,359,062 (E)
                                                               ----------       ----------        ----------         ----------
                 Total operating costs and                  
                        administrative expenses               170,119,230       14,738,292              -           184,857,522
                                                               ----------       ----------        ----------         ----------
          Operating income                                     19,841,505        3,301,832                           23,143,337
                                                            
                                                            
 Interest expense, net                                          1,288,837           68,373                            1,357,210
 Interest expense, shareholder                                    369,366                -                              369,366
 Income from investment in affiliates                            (709,295)               -              -              (709,295)
                                                               ----------       ----------        ----------         ----------
                                                            
 Income before provision for income taxes                      18,892,597        3,233,459                           22,126,056
 Income tax expense                                             6,836,066                -       1,293,385 (F)        8,129,451
                                                               ----------       ----------        ----------         ----------
                                                                                                                             -
                                                                                       
 Net income (loss)                                           $ 12,056,531     $   3,233,459    $(1,293,385)       $  13,996,605
                                                              ===========        ==========     ==========           ========== 
 Net income per weighted average share                       $       0.54                                         $        0.50
                                                              -----------                                            ==========
 Weighted average number of shares outstanding (I)             22,511,448                                            27,756,881
                                                              ===========                                            ==========
                                                            
</TABLE>

<PAGE>
                   PRO FORMA COMBINED STATEMENTS OF OPERATIONS

                          Year Ended December 31, 1995
                                   (Unaudited)



<TABLE>
<CAPTION>
                                                                                           Clinical              Combined
                                                                     PhyMatrix              Studies              Pro Forma
                                                                     ---------              -------              ---------
                                                                       (C)                    (D)

<S>                                                                <C>                   <C>                  <C>       
 Net revenues from services                                        $ 48,360,716          $ 13,351,843         $  61,712,559
 Net revenue from management service agreements                      22,372,566                     -            22,372,566
                                                                    -----------           -----------            ----------
                 Total revenue                                       70,733,282            13,351,843            84,085,125
                                                                    -----------           -----------            ----------
                                                            
                                                            
 Operating costs and administrative expenses:               
         Cost of affiliated physician management services             9,655,973                     -             9,655,973
         Salaries, wages and benefits                                29,708,554             3,832,215            33,540,769
         Salaries, wages and benefits - related party                 2,267,891                     -             2,267,891
         Professional fees                                            2,571,459             1,895,438             4,466,897 (E)
         Professional fees - related party                              273,941                     -               273,941
         Supplies                                                    11,864,514               252,848            12,117,362
         Utilities                                                    1,307,564               191,191             1,498,755
         Depreciation and amortization                                3,862,519                92,992             3,955,511
         Rent                                                         4,043,465               598,679             4,642,144
         Rent - related party                                           459,732                     -               459,732
         Earnout payment                                              1,271,000                     -             1,271,000
         Provision for closure loss                                   2,500,000                     -             2,500,000
         Provision for bad debt                                         744,111                     -               744,111
         Other                                                        5,409,676             3,581,276             8,990,952 (E)
         Other - related party                                          728,116                     -               728,116
                                                                    -----------           -----------            ----------
                 Total operating costs and                                                                    
                        administrative expenses                      76,668,515            10,444,639            87,113,154
                                                                    -----------           -----------            ----------
          Operating income (loss)                                    (5,935,233)            2,907,204            (3,028,029)
                                                            
                                                                                                                          -
                                                            
 Interest expense, net                                                3,144,027               (23,971)            3,120,056
 Interest expense, shareholder                                        1,708,174                     -             1,708,174
 Minority interest                                                      806,637                     -               806,637
 Income from investment in affiliates                                  (569,156)                    -              (569,156)
                                                                    -----------           -----------            ----------

 Income (loss) before provision for income taxes                    (11,024,915)            2,931,175            (8,093,740)
                                                            
 Income tax expense (G)                                                      -                      -                     -
                                                                    -----------           -----------            ----------
                                                            
                                                                                                                          -
 Net income (loss)(H)                                              $(11,024,915)         $  2,931,175         $  (8,093,740)
                                                                   ============            ==========           ===========

</TABLE>

<PAGE>
                   PRO FORMA COMBINED STATEMENTS OF OPERATIONS

                          Year Ended December 31, 1994
                                   (Unaudited)


<TABLE>
<CAPTION>
                                                                                             Clinical             Pro Forma
                                                                    PhyMatrix                 Studies             Combined
                                                                   ----------               ----------            ---------
                                                                     (C)                      (D)
<S>                                                                <C>                     <C>                   <C>       
 Net revenues from services                                        $2,446,821              $4,921,285            $7,368,106
 Net revenue from management service agreements                             -                       -                     -
                                                                   ----------              ----------            ----------
                 Total revenue                                      2,446,821               4,921,285             7,368,106
                                                                   ----------              ----------            ----------

 Operating costs and administrative expenses:
         Cost of affiliated physician management services                   -                                             -
         Salaries, wages and benefits                               1,207,750               1,813,752             3,021,502
         Salaries, wages and benefits - related party                 934,200                       -               934,200
         Professional fees                                             58,665                 815,747               874,412(E)
         Professional fees - related party                            253,995                       -               253,995
         Supplies                                                     404,911                 278,045               682,956
         Utilities                                                     77,416                 124,223               201,639
         Depreciation and amortization                                107,387                  58,851               166,238
         Rent                                                          56,244                 305,647               361,891
         Rent - related party                                         192,242                       -               192,242
         Other                                                         53,665               1,623,017             1,676,682(E)
         Other - related party                                        249,316                       -               249,316
                                                                   ----------               ---------             ---------
            Total operating costs and administrative expenses       3,595,791               5,019,282             8,615,073
                                                                   ----------               ---------             ---------
           Operating loss                                          (1,148,970)                (97,997)           (1,246,967)
                                                                                                                          -
 Interest expense, net                                                 95,069                     705                95,774
  Minority interest                                                    52,698                       -                52,698
                                                                   ----------               ---------             ---------
 Loss before provision for income taxes                            (1,296,737)                (98,702)           (1,395,439)
 Income tax expense (G)                                                     -                       -                     -
                                                                   ----------               ---------             ---------
 Net loss (H)                                                       
                                                                  $(1,296,737)               $(98,702)          $(1,395,439)
                                                                  ===========               =========           ===========
</TABLE>

<PAGE>


           NOTES TO UNAUDITED PRO FORMA COMBINED FINANCIAL INFORMATION




A.   To record estimated transaction expenses and the one-time costs to buy out
     a consulting contract as shown below:
<TABLE>
<CAPTION>
                                                    Clinical
                                                     Studies                PhyMatrix                   Total
                                                ------------------      -------------------      --------------------
<S>                                                    <C>                        <C>                    <C>
Legal                                                  $  200,000                 $300,000                $  500,000
Accounting                                                200,000                  175,000                   375,000
Investment Banking                                      3,600,000                  325,000                 3,925,000
Other                                                     250,000                  100,000                   350,000
                                                ------------------      -------------------      --------------------
     Subtotal transaction expenses                      4,250,000                  900,000                 5,150,000
                                                ------------------      -------------------      --------------------
CNS Consulting (1)                                      5,000,000                        0                 5,000,000
                                                ==================      ===================      ====================
     Total                                             $9,250,000                 $900,000               $10,150,000
                                                ==================      ===================      ====================
</TABLE>

(1)      Represents buyout of consulting contract.

NOTE:    The transaction will be accounted for using the pooling of interests
         method of accounting and, therefore, these transaction expenses and the
         one-time costs to buy out a consulting contract will be recorded as a
         one-time charge on PhyMatrix' Statement of Operations during the
         quarter in which the transaction closes.

B.   Represents the estimated remaining dividends to be paid in connection with
     CSL's shareholders' S corporation tax liability for the period ended July
     31, 1997.

C.   Derived from the audited combined statements of operations of PhyMatrix for
     the period from June 24, 1994 (inception) to December 31, 1994 and the year
     ended December 31, 1995 and the audited consolidated statement of
     operations for the year ended January 31,1997, and the unaudited six months
     ended July 31, 1997. In January 1996, the Company changed its fiscal year
     end from December 31, to January 31.

D.   Derived from the audited combined statements of operations of CSL for the
     years ended December 31, 1994, 1995 and 1996, including certain
     reclassifications to conform to the PhyMatrix presentation and the
     unaudited six months ended July 31, 1997. The audited combined financial
     statements of CSL for the years ended December 31, 1994, 1995 and 1996 are
     attached as Annex D.



<PAGE>



E.   The following items reflect noncontinuing charges incurred by CSL during
     the respective periods:

<TABLE>
<CAPTION>
                                                                                                                        Six
                                                                                                                       Months
                                                                              Year Ended                               Ended
                                                         ------------------------------------------------------
                                                          December 31,       December 31,        December 31,         July 31,
                                                              1994               1995                1996               1997
                                                         ---------------     --------------     ---------------     -------------
                                                          (unaudited)         (unaudited)        (unaudited)        (unaudited)
<S>                                                        <C>                <C>               <C>                  <C>
Salaries expense related to the equity interest            $        -         $        -           $  628,000        $        -
granted to an officer of CSL.  During January     
1997, the officer entered into an employment
agreement with no provisions for sharing of profits
or proceeds.

Consulting fees based on a profit sharing                      120,000            433,000             314,000                 -
arrangement.  The profit sharing arrangement was
terminated during 1997.

Management fees paid to the principal shareholders             802,000          1,700,000             987,000           907,000
of CSL
                                                         ---------------     --------------     ---------------     -------------

Total nonrecurring items                                       922,000          2,133,000           1,929,000           907,000

After tax impact of nonrecurring items                         922,000          2,133,000           1,157,400           544,200

PhyMatrix pro forma net income (loss)                       (1,395,439)        (8,093,740)         13,996,605(1)      8,573,903

PhyMatrix pro forma net income (loss) adjusted for         $  (473,439)       $(5,960,740)        $15,154,005        $9,118,103
nonrecurring items

PhyMatrix pro forma EPS adjusted for nonrecurring                    -                  -               $0.55             $0.31
items(I)
</TABLE>

(1)    Represents the PhyMatrix pro forma net income 
       for the year ended January 31, 1997.


F.   Represents an adjustment of $1,293,385 and $251,792 during the year ended
     January 31, 1997 and the six months ended July 31, 1997 for income taxes on
     the adjusted CSL net income at an estimated tax rate of 40%. No income
     taxes were provided in the historical financial statements of CSL because
     CSL had elected to be treated as an S Corp.

G.   Provisions for income taxes have not been reflected for the years ended
     December 31, 1994 and 1995 because there is no taxable income on a combined
     basis.

H.   Prior to January 23, 1996 (date of PhyMatrix' initial public offering),
     there were no outstanding shares of Common Stock and, accordingly, no
     earnings per share.

I.   Pro forma combined weighted average number of shares outstanding includes
     5,245,433 shares estimated to be issued to the stockholders of CSL 
     pursuant to the merger. The actual shares to be issued will be determined
     based on the average closing price of the Common Stock for the five 
     business days prior to the merger.


<PAGE>
                                    SIGNATURE

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                          PHYMATRIX CORP.


                                          By: /s/ Frederick R. Leathers
                                             ---------------------------------
                                               Frederick R. Leathers,
                                               Chief Financial Officer


Date:  October 6, 1997




                                       -4-

<PAGE>




                                  EXHIBIT INDEX


Exhibit No.                Exhibit Item
- -----------                -----------------------------------

2.1                        Amended and Restated Agreement and Plan of Merger
                           dated as of July 15, 1997 by and among the Company,
                           PhyMatrix Acquisition I, Inc., a Delaware corporation
                           ("PhyMatrix Acquisition"), Clinical Studies Ltd., a
                           Delaware corporation ("CSL"), Dr. Michael
                           Rothman, Dr. Walter Brown, Michael T. Heffernan and
                           Ronald Phillips as Trustee of The Alexander Rothman
                           1993 Qualified Sub-Chapter S Trust and as Trustee of
                           The Julie Rothman 1993 Qualified Sub-Chapter S Trust.

23.1                       Consent of Deloitte & Touche LLP

23.2                       Consent of Sansiveri, Kimball & McNamee, L.L.P.

27.1                       Financial Data Schedule





                                       -5-







- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
                              AMENDED AND RESTATED
                          AGREEMENT AND PLAN OF MERGER

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                                      Among

                     CLINICAL STUDIES LTD., PHYMATRIX CORP.,
                     DR. MICHAEL ROTHMAN, DR. WALTER BROWN,
                MICHAEL T. HEFFERNAN, RONALD PHILLIPS AS TRUSTEE
                     OF THE ALEXANDER ROTHMAN 1993 QUALIFIED
                    SUB-CHAPTER S TRUST AND AS TRUSTEE OF THE
                JULIE ROTHMAN 1993 QUALIFIED SUB-CHAPTER S TRUST
                        AND PHYMATRIX ACQUISITION I, INC.



                          With Respect to the Merger of

                          PHYMATRIX ACQUISITION I, INC.

                                  With and Into

                             CLINICAL STUDIES, LTD.



                                  July 15, 1997

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

<PAGE>


                                TABLE OF CONTENTS

<TABLE>
<CAPTION>

                                                                            PAGE
<S>            <C>                                                            <C>
ARTICLE I      THE MERGER                                                      1

     1.1       Execution, Filing and Effective Time                            1
     1.2       Constituent and Surviving Corporations; Effect of Merger        2
     1.3       Certificate of Incorporation and Bylaws                         2
     1.4       Officers and Boards of Directors                                2
     1.5       Conversion of Stock and Other Securities of the                 2
                 Constituent Corporations
     1.6       Exchange of Shares                                              4
     1.7       Dissenting Shares                                               6
            
ARTICLE II     CLOSING                                                         6

     2.1       The Closing Date                                                6
     2.2       The Closing                                                     6
     2.3       Filing Certificate of Merger                                    6
     2.4       Payment of Deductible Expenses                                  7
            
ARTICLE III    REPRESENTATIONS AND WARRANTIES                                  7
                    OF THE COMPANY

     3.1       Organization and Qualification                                  7
     3.2       The Subsidiaries of the Company                                 7
     3.3       Capitalization                                                  7
     3.4       Corporate Power and Authority                                   8
     3.5       No Violation                                                    8
     3.6       Financial Statements                                            9
     3.7       Books and Records                                               9
     3.8       Absence of Undisclosed Liabilities                              9
     3.9       Conduct of Business Since the Balance Sheet Date               10
     3.10      Tangible Properties                                            11
     3.11      Premises                                                       12
     3.12      Licenses and Permits                                           12
     3.13      Company Proprietary Assets                                     13
     3.14      Outstanding Commitments                                        14
     3.15      Litigation                                                     14


                                      -i-
<PAGE>

     3.16      Compliance with Law                                            15
     3.17      Labor and Employee Relations                                   16
     3.18      Certain Employees                                              16
     3.19      Employee Benefits                                              16
     3.20      Insurance                                                      18
     3.21      Transactions with Affiliates                                   18
     3.22      Taxes                                                          18
     3.23      Brokers                                                        19
     3.24      Environmental Laws                                             19
     3.25      Accounts Receivable                                            20
     3.26      SEC Filings                                                    21
     3.27      Disclosure                                                     21
            
ARTICLE IV     REPRESENTATIONS AND WARRANTIES
                    OF ACQUISITION AND PHMX                                   21

     4.1       Organization                                                   21
     4.2       Power and Authority                                            22
     4.3       No Violation                                                   22
     4.4       SEC Reports                                                    22
     4.5       Broker                                                         22
     4.6       Proxy Statement                                                23
     4.7       Disclosure                                                     23
     4.8       Form S-3                                                       23
            
ARTICLE V      COVENANTS OF THE COMPANY                                       23

     5.1       Best Efforts Cooperation                                       23
     5.2       Access                                                         24
     5.3       Insurance                                                      24
     5.4       Compliance with Laws                                           24
     5.5       Keeping of Books and Records                                   24
     5.6       Conduct of Business                                            24
     5.7       Litigation                                                     26
     5.8       Continued Effectiveness of Representations and Warranties      26
     5.9       No Negotiations                                                26
     5.10      Monthly Statements; Daily Census                               27
     5.11      Covenant Not To Compete                                        27
     5.12      Non-Disturbance Agreements                                     27
     5.13      Further Assurances                                             27
     5.14      Certain Agreements                                             28
     5.15      Pension, Profit Sharing and other Retirement Plans             28



                                      -ii-

<PAGE>


ARTICLE VI     COVENANTS OF ACQUISITION AND PHMX                              28

     6.1       Best Efforts Cooperation                                       28
     6.2       Registration of PHMX Common Stock                              28
     6.3       Special Report on Form 8-K                                     28

ARTICLE VII    MUTUAL COVENANTS                                               29

     7.1       General Covenants                                              29
     7.2       Proxy Statement                                                29
     7.3       Shareholder Approval                                           30
     7.4       Public Announcements                                           30
     7.5       Confidentiality                                                31
     7.6       Additional Covenants of the Founders,
               Mr. Heffernan and the Trustee                                  31
             
ARTICLE VIII   CONDITIONS TO ACQUISITION'S OBLIGATIONS                        32

     8.1       Representations and Warranties True                            32
     8.2       Performance                                                    32
     8.3       Consents                                                       32
     8.4       No Material Adverse Change                                     32
     8.5       No Actions, Suits or Proceedings                               32
     8.6       Opinion of Counsel                                             33
     8.7       Accountants                                                    33
     8.8       SEC Determination of Pooling of Interests                      33
     8.9       Approval of Acquisition and Its Counsel                        33
     8.10      Closing Documents                                              33
     8.11      Fairness Opinion                                               34
     8.12      Corporate Approvals                                            34
     8.13      Dissenting Shareholders                                        34
     8.14      Minimum Net Worth                                              34
     8.15      Mendels Release                                                35

ARTICLE IX     CONDITIONS TO THE COMPANY'S OBLIGATIONS                        35

     9.1       Representations and Warranties to be True and Correct          35
     9.2       No Actions, Suits or Proceedings                               35
     9.3       Opinion of Acquisition's Counsel                               35
     9.4       Performance                                                    35


                                     -iii-


<PAGE>

     9.5       Closing Documents                                              35
     9.6       Approval of the Company and their Counsel                      

     9.7       No Material Adverse Change                                     36
     9.8       Employees of the Company                                       36

ARTICLE X      MUTUAL CONDITIONS                                              36

    10.1       No Injunctions or Restraints; Illegality                       36
    10.2       Pooling of Interests                                           36
    10.3       Shareholder Agreement                                          36
    10.4       Registration of Merger Consideration Post-Closing              37
    10.5       No Material Adverse Economic Event                             37

ARTICLE XI     SURVIVAL                                                       37

ARTICLE XII    INDEMNIFICATION                                                38

    12.1       Indemnification by the Company, the Founders, the
                Trustee and Mr. Heffernan                                     38
    12.2       Indemnification by PHMX                                        39
    12.3       Indemnification Procedures                                     40
    12.4       Indemnification Concerning Mendels                             41
             
ARTICLE XIII   TERMINATION                                                    41

    13.1       Termination                                                    41
    13.2       Effect of Termination                                          42
             
ARTICLE XIV    MISCELLANEOUS                                                  43

    14.1       Certain Definitions                                            43
    14.2       Notices                                                        47
    14.3       Entire Agreement                                               48
    14.4       Modifications and Amendments                                   49
    14.5       Waivers and Consents                                           49
    14.6       Assignment                                                     49
    14.7       Parties in Interest                                            49
    14.8       Governing Law                                                  50
    14.9       Jurisdiction and Service of Process                            50
    14.10      Severability                                                   50
    14.11      Interpretation                                                 50
    14.12      Headings and Captions                                          50


                                      -iv-


<PAGE>

    14.13      Choice of Remedies and Enforcement                             51
    14.14      Expenses                                                       51
    14.15      Counterparts                                                   51

                                    EXHIBITS

      1.1     -   Certificate of Merger
      8.6     -   Opinion of Counsel of the Company
      9.3     -   Opinion of Acquisition's Counsel
      9.8     -   Employees of the Company
     10.3     -   Shareholder Agreement
     10.4     -   Registration Agreement

                                    SCHEDULES

      3.1     -   Organization and Qualification
      3.2     -   The Subsidiaries of the Company
      3.3     -   Capitalization
      3.5     -   No Violation
      3.6     -   Financial Statements
      3.9     -   Conduct of Business Since the Balance Sheet Date
      3.10(a) -   Tangible Properties
      3.10(b) -   Tangible Properties -- Valuation
      3.11    -   Premises
      3.12(a) -   Licenses
      3.12(b) -   Permits
      3.13    -   Company Propriety Assets
      3.14    -   Outstanding Commitments
      3.15    -   Litigation
      3.16    -   Compliance with Law
      3.18    -   Certain Employees
      3.19    -   Employee Benefits
      3.20    -   Insurance
      3.21    -   Transactions with Affiliates
      3.22    -   Taxes
      3.23    -   Brokers
      3.24    -   Environmental Matters
      3.25    -   Accounts Receivable

      4.3     -   SEC Reports
      4.5     -   Broker
</TABLE>


                                      -4-

<PAGE>
                              AMENDED AND RESTATED
                          AGREEMENT AND PLAN OF MERGER

                 This Amended and Restated Agreement and Plan of Merger is made
and entered into effective as of July 15, 1997 by and among PhyMatrix Corp., a
Delaware corporation ("PHMX"), PhyMatrix Acquisition I, Inc., a Delaware
corporation ("Acquisition"), Clinical Studies, Ltd., a Delaware corporation (the
"Company"), Dr. Michael Rothman, a resident of Newton Lower Falls, Massachusetts
("Rothman"), Dr. Walter Brown, a resident of Tiverton, Rhode Island ("Brown,"
and collectively with Rothman, the "Founders"), Michael T. Heffernan, a resident
of Hingham, Massachusetts ("Heffernan") and Ronald Phillips as Trustee of The
Alexander Rothman 1993 Qualified Sub-Chapter S Trust and as Trustee of The Julie
Rothman 1993 Qualified Sub-Chapter S Trust (in his capacity as Trustee of each
aforesaid trust, and not individually, the "Trustee").

                                   BACKGROUND

                 A. The Company is a site management organization conducting
clinical research for pharmaceutical companies and for clinical research
organizations (collectively, with all activities incidental thereto, the
"Business") at 20 centers located in eight states (the "Centers").

                 B. Pursuant to the Merger, the holders of shares of common
stock, par value $.0001 per share, of the Company (the "Company Common Stock")
will receive shares of PHMX common stock, par value $.01 per share (the "PHMX
Common Stock"), in the manner set forth in Article I of this Agreement and upon
the terms and conditions otherwise set forth in this Agreement.

                 C. The Board of Directors of each of the Company and
Acquisition has determined that the Merger is fair and in the best interests of
their respective stockholders, has approved and adopted this Agreement and the
transactions contemplated hereby and has resolved to recommend to the
stockholders of their respective corporations that they approve this Agreement
and the Merger.

                 NOW, THEREFORE, in consideration of the foregoing premises and
of the mutual agreements hereinafter contained, the parties hereto agree as
follows:

                                    ARTICLE I
                                   THE MERGER

                 1.1 Execution, Filing and Effective Time. On the Closing Date
(as hereinafter defined) and subject to the terms and conditions hereinafter set
forth, the parties hereto agree to cause the Merger to be consummated by filing
with the Delaware Secretary of State a Certificate of Merger (the "Certificate
of Merger") in the form set forth in Exhibit 1.1 hereto, duly executed and
acknowledged by the Company, and taking all such further actions as may be
required by law to make the Merger effective. The Merger shall become effective
when the Certificate of Merger is so filed in accordance with the Delaware
General Corporation Law (the


<PAGE>

"Delaware Law"), and the time at which the Merger becomes effective is referred
to herein as the "Effective Time."

                 1.2 Constituent and Surviving Corporations; Effect of Merger.
The Company and Acquisition shall be the constituent corporations in the Merger,
and the Company shall be the surviving corporation in the Merger (in such
capacity, the Company is sometimes hereinafter referred to as the "Surviving
Corporation"). At the Effective Time, the Merger shall have the effect set forth
in Section 259 of the Delaware Law.

                 1.3 Certificate of Incorporation and Bylaws. At the Effective
Time, the Certificate of Incorporation of Acquisition shall be the Certificate
of Incorporation of the Surviving Corporation and the By-laws of Acquisition as
in effect at the Effective Time shall constitute the By-laws of the Surviving
Corporation.

                 1.4 Officers and Boards of Directors.

                 (a) At the Effective Time, each of the members of the Board of
Directors and each of the officers of the Company immediately prior to the
Effective Time shall resign or be removed from office and, concurrently with
such removal or resignation, the directors and officers of Acquisition shall
become the directors and officers of the Surviving Corporation, each to serve in
accordance with the By-laws of the Surviving Corporation until his successor is
duly elected and qualified.

                 (b) Prior to the Effective Time, the management of PHMX will
recommend Mr. Heffernan for election to the Board of Directors of PHMX.

                 1.5 Conversion of Stock and Other Securities of the Constituent
Corporations. At the Effective Time, without any action on the part of the
holder thereof:

                 (a) Each share of Company Common Stock issued and outstanding
immediately prior to the Effective Time that is not then held in the treasury of
the Company shall be cancelled and extinguished and be converted into the right
to receive, upon surrender to the Surviving Corporation of the Certificate (as
defined herein) representing such share, such shares of PHMX Common Stock as set
forth below (the "Merger Consideration"):

                           (i) Each share of Company Common Stock shall be
         converted into a right to receive such number of shares of PHMX Common
         Stock equal to the Aggregate Share Pool (as defined herein) divided by
         the total number of shares of Company Common Stock outstanding
         immediately prior to the Closing on a fully diluted basis, taking into
         account all shares of Company Common Stock issuable upon exercise of
         the Employee Stock Options (as defined herein) whether or not such
         Employee Stock Options are currently vested.



                                      -2-
<PAGE>

                           (ii) The "Aggregate Share Pool" shall be determined
         based upon the average last reported sale price of PHMX Common Stock as
         quoted on Nasdaq (as defined herein) for the five (5) business days
         preceding the last business day prior to the Closing (the "Average
         Closing Price Per Share" or "ACPPS") in accordance with the following
         terms:

                                     (x) if the Average Closing Price Per Share
                  is greater than Sixteen Dollars and Fifty Cents ($16.50), the
                  Aggregate Share Pool shall equal Eighty-Seven Million Eight
                  Hundred Forty-Four Thousand Six Hundred Thirty-Eight
                  (87,844,638) divided by the ACPPS;

                                     (y) if the Average Closing Price Per Share
                  is greater than or equal to Thirteen Dollars and Fifty Cents
                  ($13.50) and less than or equal to Sixteen Dollars and Fifty
                  Cents ($16.50), the Aggregate Share Pool shall equal Five
                  Million Eight Hundred Sixty-Six Thousand Six Hundred
                  Sixty-Seven (5,866,667) minus the quotient of 8,955,362
                  divided by the ACPPS; or

                                     (z) if the Average Closing Price Per Share
                  is less than Thirteen Dollars and Fifty Cents ($13.50), then
                  the Aggregate Share Pool shall equal Seventy Million Two
                  Hundred Forty-Four Thousand Six Hundred Thirty-Eight
                  (70,244,638) divided by the ACPPS.

                 (b) Each share of the common stock, $.01 par value, of
Acquisition issued and outstanding immediately prior to the Effective Time shall
be converted into the right to receive, upon the surrender to the Surviving
Corporation of the certificate representing such share, one (1) fully paid and
nonassessable share of common stock of the Surviving Corporation (i.e., one
share of Company Common Stock), which shares of the Surviving Corporation
thereupon shall constitute all of the issued and outstanding shares of capital
stock of the Surviving Corporation.

                 (c) As soon as practicable following the date of this
Agreement, but in no event later than thirty (30) days following the Effective
Time, the Board of Directors of the Surviving Corporation (or, if appropriate,
any committee administering the Stock Plan (as defined below)) shall adopt such
resolutions or take other actions as may be required to effect the following:

                           (i) adjust the terms of all outstanding employee
         stock options to purchase Company Common Stock ("Employee Stock
         Options") granted under the Clinical Studies 1996 Equity Incentive Plan
         (the "Stock Plan"), to provide that, at the Effective Time, each
         Employee Stock Option outstanding immediately prior to the Effective
         Time shall be deemed to constitute an option to acquire, on the same
         terms and conditions as were applicable under such Employee Stock
         Option, the same number of shares of PHMX Common Stock as the holder of
         such Employee Stock Option would have been entitled



                                      -3-
<PAGE>

         to receive pursuant to the Merger had such holder exercised such
         Employee Stock Option in full immediately prior to the Effective Time
         at a price per share equal to the exercise price per share of each
         Employee Stock Option immediately prior to the Merger divided by the
         Conversion Rate (as defined herein).

                 (d) As soon as practicable after the Effective Time, but in no
event later than thirty (30) days following the Effective Time, PHMX shall
deliver to the holders of Employee Stock Options appropriate notices setting
forth such holders' rights pursuant to the Stock Plan and the agreements
evidencing the grants of such Employment Stock Options appropriate notices
setting forth such holders' rights pursuant to the Stock Plan and the agreements
evidencing the grants of such Employee Stock Options shall continue in effect on
the same terms and conditions (subject to the adjustments required by this
Section 1.5 after giving effect to the Merger). PHMX shall comply with the terms
of the Stock Plan and ensure, to the extent required by, and subject to the
provisions of, such Stock Plan, that the Employee Stock Options which qualified
as ISOs prior to the Effective Time continue to qualify as ISOs after the
Effective Time.

                 (e) PHMX shall take all corporate action necessary to reserve
for issuance a sufficient number of shares of PHMX Common Stock for delivery
upon exercise of the Employee Stock Options for delivery upon purchase as
provided in paragraph (c) above assumed in accordance with this Section 1.5.
With respect to those individuals who subsequent to the Merger will be subject
to the reporting requirements under Section 16(a) of the Exchange Act, where
applicable, PHMX shall administer the Stock Plan assumed pursuant to this
Section 1.5 in a manner that complies with Rule 16b-3 promulgated under the
Exchange Act to the extent the Stock Plan complied with such rule prior to the
Merger.

                 1.6 Exchange of Shares.

                 (a) At the Closing and on behalf of the Company Shareholders
(as defined herein), the Company shall deliver to PHMX certificates representing
all of the outstanding shares of Company Common Stock (the "Certificates") and a
schedule including the address and social security or taxpayer identification
number of each holder of a Certificate (each a "Company Shareholder").

                 (b) No later than fifteen (15) days following the receipt of a
Certificate following the Effective Time, PHMX shall instruct its transfer agent
(the "Exchange Agent") to deliver to each of the Company Shareholders, as
applicable, a certificate representing that number of whole shares of PHMX
Common Stock to which such Company Shareholder shall have become entitled
pursuant to the provisions of Article I hereof. Simultaneously therewith, the
PHMX shall deliver a check representing the amount of cash in lieu of any
fractional share that such Company Shareholder has the right to receive pursuant
to the provisions of Article I hereof. The Certificate(s) so surrendered shall
forthwith be canceled. No interest will be paid or accrued on the cash paid in
lieu of any fractional share to holders of Certificates.



                                      -4-
<PAGE>

                 (c) No dividends or other distributions declared after the
Effective Time with respect to PHMX Common Stock shall be paid to the holder of
any unsurrendered Certificate until the holder thereof shall surrender such
Certificate in accordance with this Article I. After the surrender of a
Certificate in accordance with this Article I, the record holder thereof shall
be entitled to receive any such dividends or other distributions, without any
interest thereon, which theretofore had become payable with respect to shares of
PHMX Common Stock represented by such Certificate after the Effective Time.

                 (d) If any certificate representing shares of PHMX Common Stock
is to be issued in a name other than that in which the Certificate surrendered
in exchange therefor is registered, it shall be a condition of the issuance
thereof that the Certificate so surrendered shall be properly endorsed (or
accompanied by an appropriate instrument of transfer) and otherwise in proper
form for transfer, and that the person requesting such exchange shall pay to the
PHMX in advance any transfer or other taxes required by reason of the issuance
of a certificate representing shares of PHMX Common Stock in any name other than
that of the registered holder of the Certificate surrendered, or required for
any other reason, or shall establish to the satisfaction of the PHMX that such
tax has been paid or is not payable.

                 (e) After the Effective Time, there shall be no transfers on
the stock transfer books of the Company of the shares of Company Common Stock
which were issued and outstanding immediately prior to the Effective Time. If,
after the Effective Time, Certificates representing such shares are presented
for transfer to the PHMX, they shall be canceled and exchanged for certificates
representing shares of PHMX Common Stock as provided in this Article I.

                 (f) Notwithstanding anything to the contrary contained herein,
no certificates or scrip representing fractional shares of PHMX Common Stock
shall be issued upon the surrender for exchange of Certificates, no dividend or
distribution with respect to PHMX Common Stock shall be payable on or with
respect to any fractional share and such fractional share interests shall not
entitle the owner thereof to vote or to any other rights of a stockholder of
PHMX. In lieu of the issuance of any such fractional shares, PHMX shall pay to
each former Company Shareholder who otherwise would be entitled to receive a
fractional share of PHMX Common Stock (after taking into account all shares of
PHMX Common Stock into which such stockholder's shares of Company Common Stock
were converted pursuant to Article I) an amount in cash (rounded to the nearest
whole cent) determined by multiplying (i) the Average Closing Price Per Share by
(ii) the fraction of a share of PHMX Common Stock which such holder would
otherwise be entitled to receive pursuant to Section 1.5 hereto.

                 (g) None of PHMX, Acquisition, the Company, the Exchange Agent
or any other person shall be liable to any former holder of shares of the
Company Common Stock for any amount properly delivered to a public official
pursuant to applicable abandoned property, escheat or similar laws.



                                      -5-
<PAGE>

                 (h) In the event any Certificate shall have been lost, stolen
or destroyed, upon the making of an affidavit of that fact by the person
claiming such Certificate to be lost, stolen or destroyed and, if required by
PHMX, the posting by such person of a bond in such amount as PHMX may determine
is reasonably necessary as indemnity against any claim that may be made against
it with respect to such Certificate, the Exchange Agent will issue in exchange
for such lost, stolen or destroyed Certificate the shares of PHMX Common Stock
and cash in lieu of any fractional share deliverable in respect thereof pursuant
to this Agreement.

                 1.7 Dissenting Shares. Notwithstanding Section 1.5(a), shares
of Company Common Stock outstanding immediately prior to the Effective Time that
are held by a holder who has not voted in favor of the Merger or consented
thereto in writing and who has demanded appraisal for such shares in accordance
with the Delaware Law shall not be converted into a right to receive the Merger
Consideration, unless such holder fails to perfect or withdraws or otherwise
loses such holder's right to appraisal under the Delaware Law. If, after the
Effective Time, such holder fails to perfect or withdraws or loses his right to
appraisal, such shares shall be treated as though they had been converted as of
the Effective Time into a right to receive the Merger Consideration, without
interest.


                                   ARTICLE II
                                     CLOSING

                 2.1 The Closing Date. Subject to the satisfaction or waiver of
each of the conditions contained in Articles VIII, IX and X of this Agreement,
the closing of the Merger and the other transactions contemplated by this
Agreement (the "Closing") shall take place at the offices of Nutter, McClennen &
Fish, LLP, One International Place, Boston, Massachusetts at 10:00 a.m. on a
date agreeable to the parties within five (5) business days after the
satisfaction or waiver of all conditions to Closing set forth in Articles VIII,
IX and X, or on such other date or at such other location or time as may be
agreed upon by the parties (such date and time being called the "Closing Date"),
but in no event later than the Termination Date (as defined in Section 13.1(d)).

                 2.2 The Closing. At the Closing, the Company, Acquisition and
PHMX shall each deliver to each other, as applicable, such certificates,
instruments, documents and opinions as are set forth in Articles VIII, IX and X,
each of which shall be fully executed and completed, as appropriate.

                 2.3 Filing Certificate of Merger. Contemporaneous with the
Closing, the duly executed Certificate of Merger shall be filed with the
Delaware Secretary of State.



                                      -6-
<PAGE>

                 2.4 Payment of Deductible Expenses. At the Closing, upon
presentation of appropriately detailed invoices by the Company, PHMX shall pay
to the applicable parties all Deductible Expenses incurred by the Company.


                                   ARTICLE III
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

                 The Company, each of the Founders, the Trustee and Mr.
Heffernan hereby represent and warrant to Acquisition and PHMX as follows:

                 3.1 Organization and Qualification. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware. The Company is qualified, or is in the process of
qualifying, to do business as a foreign corporation in each jurisdiction where
it is required to be so qualified and each such jurisdiction and the status of
its qualification is set forth on Schedule 3.1 hereto. As of the Closing Date,
the Company will be qualified to do business as a foreign corporation in each
jurisdiction where it is required to be so qualified. The Company has previously
furnished to PHMX true and complete copies of its Certificate of Incorporation
and By-laws, as amended to date.

                 3.2 The Subsidiaries of the Company. Except as set forth on
Schedule 3.2, Clinical Marketing, Ltd., a Delaware corporation (the
"Subsidiary"), is the Company's sole subsidiary corporation. The Subsidiary is
qualified to do business as a foreign corporation in each jurisdiction where it
is required to be so qualified. All issued and outstanding shares of the
Subsidiary are duly authorized, validly issued, fully paid and nonassessable and
the Company is the sole owner of all such issued and outstanding shares. There
are no outstanding or authorized options, warrants, purchase rights,
subscription rights, conversion rights, exchange rights or other contracts or
commitments that require the Subsidiary to issue, sell or otherwise cause to
become outstanding any of its capital stock or other securities. There are no
outstanding or authorized stock appreciation, phantom stock, profit
participation or similar rights with respect to the Subsidiary. There are no
stockholders' agreements, voting trusts, proxies or other agreements or
understandings with respect to the voting or ownership of the capital stock of
the Subsidiary. The Company does not control directly or indirectly or have any
direct or indirect equity participation in any corporation, partnership, joint
venture, trust or other business association other than the Subsidiary.

                 3.3 Capitalization. The authorized capital stock of the Company
consists of 1,000,000 shares of Company Common Stock of which 900,039.51 shares
are outstanding. All of the outstanding shares of the capital stock of the
Company have been validly issued and are fully paid and nonassessable. Except as
set forth in Schedule 3.3, there are no outstanding options, warrants, rights,
or other agreements or commitments obligating the Company to issue or sell
shares of its capital stock or any securities or obligations convertible into or
exchangeable




                                      -7-
<PAGE>

for any shares of its capital stock. Schedule 3.3 is a true and correct summary
of the exercise or conversion price, vesting schedule and amount of underlying
securities, with respect to all such options, warrants, rights, agreements or
commitments or securities or obligations convertible into or exchangeable for
shares of the Company's capital stock and attached to such Schedule are all
plans and agreements relating thereto. The Company has no obligation to register
any shares of its capital stock under the Securities Act (as defined herein).
Except as set forth on Schedule 3.3, the Company is not obligated directly,
indirectly or contingently to purchase or redeem any shares of its capital
stock.

                 3.4 Corporate Power and Authority. The Company and its
Subsidiary have full corporate power and authority to carry on the Business and
any other activities related thereto as now being conducted and to own, operate
and lease their properties in the places where such Business or other activities
related thereto are now conducted and such properties are now owned, leased or
operated. This Agreement, the Merger and the other transactions contemplated
hereby have been duly and unanimously approved by the Board of Directors of the
Company. The Company has full corporate power and authority to enter into this
Agreement and to consummate the Merger and the other transactions contemplated
hereby, and this Agreement and each of the other agreements to be executed and
delivered by the Company in connection herewith constitute the legal, valid and
binding obligations of the Company enforceable against it in accordance with
their respective terms.

                 3.5 No Violation. Neither the execution and delivery of this
Agreement and the other documents and instruments contemplated hereby and the
consummation of the Merger and the other transactions contemplated hereby, nor
the performance of this Agreement and such other documents and instruments in
compliance with the terms and conditions hereof and thereof, except as set forth
in Schedule 3.5, will (i) violate, conflict with or result in any breach of any
trust agreement, charter document, by-law, judgment, decree, order, statute or
regulation applicable to the Company or its Subsidiary, (ii) require any
consent, approval, authorization or permit of, or filing with or notification
to, any Governmental Authority (as defined herein) (other than filing the
Certificate of Merger with the Delaware Secretary of State), (iii) violate,
conflict with or result in a breach, default or termination or give rise to any
right of termination, cancellation or acceleration of the maturity of any
payment date of any obligation of the Company or its Subsidiary or increase or
otherwise affect the obligations of the Company or its Subsidiary under any Law
or Permit (each as defined herein) or any of the terms, conditions or provisions
of any mortgage, indenture, note, license, agreement or other instrument or
obligation related to the Company or its Subsidiary or to the Company's ability
to consummate the Merger and the other transactions contemplated hereby, except
for such defaults (or rights of termination, cancellation or acceleration) as to
which requisite waivers or consents, in form and substance satisfactory to PHMX,
have been or will be obtained in writing and provided to PHMX at or prior to the
Closing, (iv) violate any order, writ, injunction, decree, statute, rule or
regulation applicable to the Company or its Subsidiary, or (v) result in the
creation of any Claim (as defined herein) upon or against the properties of the
Company or its Subsidiary.



                                      -8-
<PAGE>

                 3.6 Financial Statements. The Company has previously furnished
to PHMX the following financial statements of the Company which are attached
hereto in Schedule 3.6: (i) financial statements as of and for the year ending
December 31, 1994 audited by Sansivieri, Kimball and McNamee, and for the years
ending December 31, 1995 and 1996, audited by Deloitte & Touche LLP, consisting
of balance sheets, statements of income, statements of retained earnings and
statements of cash flows, and (ii) financial statements as of and for the three
months ended March 31, 1997, prepared internally by the Company, consisting of a
balance sheet and income statement (collectively, the "the Company Financial
Statements"). The balance sheet of the Company dated March 31, 1997 and included
among the Company Financial Statements is referred to herein as the "Balance
Sheet." All the Company Financial Statements were prepared from the books and
records of the Company, which books and records are complete and correct. The
Company Financial Statements fairly present the financial position of the
Company as of the dates thereof and the results of the Company's operations for
the periods presented therein, as the case may be, all in conformity with GAAP
(as defined herein), consistently applied, subject, in the case of the financial
statements for the three months ended March 31, 1997, to normal year-end
adjustments.

                 3.7 Books and Records. The books of account, minute books,
stock record books, and other records of the Company and its Subsidiary, all of
which have been made available to PHMX, are complete and correct and have been
maintained in accordance with sound business practices and the requirements of
Section 13(b)(2) of the Exchange Act (as defined herein) (regardless of whether
or not the Company or its Subsidiary is subject to that Section), including the
maintenance of an adequate system of internal controls. The minute books of the
Company and its Subsidiary contain accurate and complete records of meetings
held of, and corporate action taken by, the stockholders, the Boards of
Directors and committees of the Boards of Directors of the Company and its
Subsidiary, and all corporate action requiring approval of the Board of
Directors or the stockholders of either the Company or its Subsidiary has been
so approved and confirmed, as required by the by-laws of each and by Delaware
Law, and such approval and confirmation has been so noted in such minute books.
As of the Closing Date, all of the books and records referenced in this Section
3.7 will be in the possession of the Company.

                 3.8 Absence of Undisclosed Liabilities. Except as set forth or
reserved against in the Balance Sheet as of March 31, 1997 (the "Balance Sheet
Date") included in the Company Financial Statements and except as set forth on
Schedule 3.9, the Company (i) did not have as of the Balance Sheet Date any
liability or obligation of any nature, whether accrued, absolute, contingent, or
otherwise and whether due or to become due, including, without limitation,
liabilities that may become known or arise after the date hereof and which
relate to transactions entered into or any state of facts existing on or before
the Balance Sheet Date which would be required under GAAP to be shown in such
balance sheet or referenced in the notes thereto, and (ii) has not incurred
since the Balance Sheet Date any such liability or obligation except in the
Ordinary Course of Business (as defined herein).



                                      -9-
<PAGE>

                 3.9 Conduct of Business Since the Balance Sheet Date. Since the
Balance Sheet Date, except as set forth on Schedule 3.9, there has been no
Material Adverse Change (as hereinafter defined) with respect to the Company,
and no such Material Adverse Change is threatened, contemplated or anticipated.
(As used herein, the term "Material Adverse Change" shall mean, with respect to
the Company, a material adverse change in the financial condition (including,
but not limited to, net worth and working capital), results of operations,
assets, liabilities, business or prospects of the Company or its Subsidiary,
and, with respect to any other Person, a material adverse change in the
financial condition (including, but not limited to, net worth and working
capital), results of operations, assets, liabilities, business prospects of such
Person). Since the Balance Sheet Date, except as set forth on Schedule 3.9,
neither the Company nor its Subsidiary has taken or agreed to take any action
that would obligate the Company or its Subsidiary to have:

                 (a) taken any action or entered into or agreed to enter into
         any transaction, agreement or commitment other than in the Ordinary
         Course of Business;

                 (b) entered into or agreed to enter into any transaction,
         agreement or commitment, or suffered the occurrence of any event or
         events (i) that has interfered or is reasonably likely to interfere
         with the normal and usual operations of the Business of the Company or
         its Subsidiary or (ii) that, singly or in the aggregate, has resulted
         or is reasonably likely to result in a Material Adverse Change with
         respect to the Company;

                 (c) incurred any indebtedness for borrowed money, or assumed,
         guaranteed, endorsed or otherwise become responsible for the
         obligations of any other Person, (except to endorse checks for
         collection for deposit in the Ordinary Course of Business), or made any
         loan or advance to any Person;

                 (d) mortgaged, pledged, or otherwise encumbered, or, other than
         in the Ordinary Course of Business, sold, transferred or otherwise
         disposed of, any of the properties or assets of the Company or its
         Subsidiary, including any cancelled, released, hypothecated or assigned
         indebtedness owed to the Company or its Subsidiary, or any Claims held
         by the Company or its Subsidiary;

                 (e) made any investment of a capital nature or entered into a
         commitment for such investment either by purchase of stock or
         securities, contributions to capital, property transfer or otherwise,
         or by the purchase of any property or assets of any other Person;

                 (f) declared, set aside, or paid any dividend or other
         distribution (whether in cash, stock or property, or any combination
         thereof) in respect of the capital stock of the Company, or redeemed or
         otherwise acquired, directly or indirectly, any shares of capital stock
         of the Company;



                                      -10-
<PAGE>

                 (g) paid any long-term liability, otherwise than in accordance
         with its terms;

                 (h) paid any bonus compensation to any officer, director,
         stockholder or employee of the Company or its Subsidiary or otherwise
         increased the compensation paid or payable to any of the foregoing;

                 (i) sold, assigned or transferred any Proprietary Assets or
         other intangible assets;

                 (j) entered into any material agreement, contract, lease,
         indenture or commitment (whether written or oral) or any amendment,
         waiver or modification to any existing agreement, contract, lease,
         indenture or commitment (whether written or oral);

                 (k) contracted with or committed to any third party (i) to sell
         any capital stock of the Company, (ii) to sell any assets of the
         Company or its Subsidiary other than in the Ordinary Course of
         Business, (iii) to effect any merger, consolidation or other
         reorganization of the Company or its Subsidiary, or (iv) to enter into
         any agreement with respect thereto; or

                 (l) paid any expenses or fees of counsel, accountants or
         consultants for services in preparation for or in connection with this
         Agreement or the transactions contemplated hereunder.

                 3.10 Tangible Properties. Schedule 3.10(a) contains a true and
complete list of all fixed assets, fixtures, furnishings, furniture, office
supplies, computer hardware and software, automobiles, tools, machinery,
equipment, spare parts and other tangible personal property owned or leased by
the Company or its Subsidiary (the "Tangible Personal Property"). Except as
listed on Schedule 3.10(a) with respect to leased Tangible Personal Property,
the Company and its Subsidiary have good and marketable title free and clear of
all Claims to the Tangible Personal Property owned by the Company or its
Subsidiary. With respect to any Tangible Personal Property leased by the Company
or its Subsidiary, all leases, conditional sale contracts, franchises or
licenses pursuant to which the Company or its Subsidiary may hold or use (or
permit others to hold or use) such Tangible Personal Property are valid and in
full force and effect, and there is not under any of such instruments any
existing default or event of default or event which with notice or lapse of time
or both would constitute such a default; and the Company's or its Subsidiary's
possession and use of such property has not been disturbed and no claim has been
asserted against the Company or its Subsidiary adverse to their rights in such
leasehold interests. All Tangible Personal Property is adequate and usable for
the purposes for which it is currently used and each item of Tangible Personal
Property, whether owned or leased, is in good operating condition, reasonable
wear and tear excepted, and has been properly maintained and repaired. The
Tangible Personal Property comprises all the equipment necessary for the
continuing operation of the Centers in the manner in which they have been
operated to



                                      -11-
<PAGE>

date. Each item of Tangible Personal Property is listed on Schedule 3.10(b) with
its book value and such value is true and correct.

                 3.11 Premises. The real property and the leases described on
Schedule 3.11 represent all the real property leased or subleased (the "Leased
Premises") and real property leases and subleases (the "Leases") entered into or
assumed by the Company or its Subsidiary, and the descriptions of such Leased
Premises and Leases are true and complete. Each Lease is in full force and
effect, and there is not under any of the Leases any existing default or event
of default or event which with notice or lapse of time or both would constitute
such a default. Each Lease conveys good and marketable leasehold title to the
leased real estate purported to be conveyed thereunder, is enforceable by the
Company or its Subsidiary which is the lessee thereunder, provides exclusive
possession of the Leased Premises leased thereunder, and, subject to the receipt
of non-disturbance agreements with respect to such Leases, following the Merger
will continue to be enforceable in accordance with its terms. The Company or its
Subsidiary which is the lessee of each respective Leased Premises has the right
to use its respective Leased Premises in accordance with the terms of each
respective Lease free and clear of all Claims. Each of the Leased Premises is
adequately maintained, fully equipped with all necessary utilities and is in
reasonably satisfactory condition and repair, consistent with the uses to which
it is presently being put or intended to be put. To the Company's Knowledge, all
structures, improvements and fixtures on the Leased Premises and the current
uses of the Leased Premises conform in all material respects to any and all
Laws, the failure to conform with which would have a material adverse effect on
the Company. To the Company's Knowledge, there is no violation of any material
covenant, restriction or other agreement or understanding, oral or written,
affecting or relating to title or use of any Leased Premises. The Company has
received no notice of any pending or threatened condemnation or similar
proceedings or assessments affecting any of the Leased Premises, nor to the best
of the Company's Knowledge is any such condemnation or assessment contemplated
by any Governmental Authority. The Company has delivered to PHMX true and
correct copies of all Leases, as amended to date. Neither the Company nor its
Subsidiary owns or has any ownership interest in any real property.

                 3.12 Licenses and Permits. Schedule 3.12(a) lists all licenses,
permits, pending applications, consents, approvals and authorizations of or from
any Governmental Authority held by the Company, the Subsidiary and each
physician employed by or under contract with the Company or its Subsidiary (each
a "Licensed Party") or used in or otherwise necessary for the conduct of the
Business (collectively, the "Permits") together with any conditions imposed
thereon. The Company and its Subsidiary have complied with all conditions and
requirements imposed by the Permits and neither the Company nor its Subsidiary
has received any notice of, or has any reason to believe, that any appropriate
authority intends to cancel, terminate or suspend any of the Permits or that
valid grounds for such cancellation, termination or suspension exist. Except as
set forth on Schedule 3.12(b), no other licenses, permits, consents, approvals
or authorizations of or from any Governmental Authority other than the Permits
are necessary to operate the Business. The Company, its Subsidiary and each
Licensed Party own or have the



                                      -12-
<PAGE>

right to use the Permits in accordance with the terms thereof without any
conflict or alleged conflict or infringement with the rights of others and
subject to no Claim. Each Permit is and immediately after the Merger will be
valid and in full force and effect and no Permit will be subject to termination
or be terminated or adversely affected by the Merger.

                 3.13 Company Proprietary Assets.

                 (a) Schedule 3.13 identifies and provides a brief description
of all Proprietary Assets (as hereinafter defined) owned or licensed to, or
otherwise used by, the Company, including, without limitation, any
pharmaceutical product utilized in the conduct of the Company's Business as well
as any plan or system utilized by the Company regarding the standards and
methods of operating the Business (collectively, the "Company Proprietary
Assets"). Schedule 3.13 lists each Person for which the Company has provided
services in connection with the Business since December 31, 1994 and provides
for each such client, the name, address, telephone number and name of contact.
Schedule 3.13 lists each trademark and service mark owned by or licensed to, or
otherwise used by, either Company and states with respect to each such trademark
or service mark, whether it is registered with the U.S. Patent and Trademark
Office or any state Governmental Agency. Except as set forth in Schedule 3.13,
the Company has good, valid and marketable title to all of the Company
Proprietary Assets identified therein, free and clear of all Encumbrances, and
have a valid right to use all such Company Proprietary Assets. Except as set
forth in Schedule 3.13, the Company is not obligated to make any payment to any
person or entity for the use of any Company Proprietary Asset. Except as set
forth in Schedule 3.13, neither Company nor its Subsidiary has developed jointly
with any other Person any Company Proprietary Asset with respect to which such
other Person has any rights.

                 (b) The Company has taken reasonably prudent steps to protect
and maintain the confidentiality and secrecy of all Company Proprietary Assets
(except Company Proprietary Assets whose value would be unimpaired by public
disclosure) and otherwise to maintain and protect the value of all Company
Proprietary Assets.

                 (c) To the best of the Company's Knowledge, none of the Company
Proprietary Assets infringes or conflicts with any Proprietary Asset owned or
used by any other Person. The Company is not infringing, misappropriating or
making any unlawful use of, and the Company has not at any time infringed,
misappropriated or made any unlawful use of, or received any notice or other
communication (in writing or otherwise) of any actual, alleged, possible or
potential infringement, misappropriation or unlawful use of, any Proprietary
Asset owned or used by any other Person. To the Knowledge of the Company, no
other Person is infringing, misappropriating or making any unlawful use of, and
no Proprietary Asset owned or used by any other person or entity infringes or
conflicts with, any Company Proprietary Asset.



                                      -13-
<PAGE>

                 (d) The Company Proprietary Assets constitute all the
Proprietary Assets necessary to enable the Companies to conduct the Business in
the manner in which the Business has been and is being conducted. Except as set
forth in Schedule 3.13: (i) neither Company nor its Subsidiary has licensed any
of the Company Proprietary Assets to any Person, and (ii) neither Company has
entered into any contract, agreement, covenant not to compete, or other
arrangement limiting its ability to exploit fully any of its Company Proprietary
Assets or to transact business in any market or geographical area or with any
Person.

                 3.14 Outstanding Commitments.

                 (a) Schedule 3.14 sets forth a list of all material existing
contracts, agreements, leases, subleases, commitments, licenses and franchises
(collectively, the "Contracts"), whether written or oral, to which the Company
or its Subsidiary is a party or which relate to the Business. The Company has
delivered or made available to PHMX true, correct and complete copies of all
written Contracts and Schedule 3.14 contains an accurate and complete
description of all Contracts which are not in writing. All of the Contracts are
in full force and effect. The Company and its Subsidiary which is a party to and
each other party to each of the Contracts have performed all the obligations
required to be performed by them to date, and there is not under any of the
Contracts any existing default or event of default or event which with notice or
lapse of time or both would constitute such a default. Neither the Company nor
its Subsidiary has (i) any present expectation or intention of not fully
performing all its obligations under each of the Contracts to which it is a
party or (ii) any Knowledge of any breach or anticipated breach by any other
party to any of the Contracts. None of the Contracts has been terminated or
notice of termination given with respect thereto, no notice has been given by
any party thereto of any alleged default thereunder by any party thereto, and
neither the Company nor its Subsidiary is aware of any intention or right of any
party to any Contract to default another party to any Contract. There exists no
actual or, to the Knowledge of the Company, threatened termination, cancellation
or limitation of the business relationship of the Company or its Subsidiary with
any party to any Contract.

                 (b) Each Contract to which the Company or its Subsidiary is a
party concerning Clinical Trials provides for indemnification of the Company and
its Subsidiary with respect to potential actions, suits, claims or proceedings
at law or in equity before any Governmental Authority or arbitration tribunal
based upon the administration of any pharmaceutical or other forms of therapy
incident to the Clinical Trials, consistent with industry practice.

                 3.15 Litigation. Except as set forth on Schedule 3.15, there is
no (i) action, suit, claim, proceeding or investigation pending or, to the best
of the Company's Knowledge, threatened against or affecting the Company or its
Subsidiary (whether or not the Company or its Subsidiary is a party or
prospective party thereto), at law or in equity, or before or by any
Governmental Authority, (ii) pending or, to the best of the Company's Knowledge,
threatened 



                                      -14-
<PAGE>

arbitration proceeding relating to the Company or its Subsidiary or (iii)
governmental inquiry, to the best of the Company's Knowledge, pending or
threatened against or involving the Company or its Subsidiary, and there is no
basis for any of the foregoing. Except as set forth on Schedule 3.15, neither
the Company nor its Subsidiary has received any opinion or memorandum or legal
advice from legal counsel to the effect that it is exposed, from a legal
standpoint, to any liability or disadvantage which may be material to the
prospects, financial condition, operations, property or affairs of the Business.
Except as set forth on Schedule 3.15, there are no outstanding orders, writs,
judgments, injunctions or decrees of any Governmental Authority or arbitration
tribunal against, involving or affecting the Company or its Subsidiary, and to
the Company's Knowledge there are no facts or circumstances which may result in
institution of any action, suit, claim or legal, administrative or arbitration
proceeding or investigation against, involving or affecting the Company or its
Subsidiary, their assets or properties, or the Merger or the transactions
contemplated hereby. Neither the Company nor its Subsidiary is in default with
respect to any order, writ, injunction or decree known to or served upon it from
any court or of any Governmental Authority. Except as set forth on Schedule
3.15, there is no action, suit or proceeding by the Company or its Subsidiary or
their affiliates pending or to the Company's Knowledge threatened against
others. Except as set forth on Schedule 3.15, none of the following has occurred
with respect to any the Company or its Subsidiary:

                 (a) Neither the Company nor its Subsidiary nor, to their
         Knowledge, any employee thereof, has been convicted in a criminal
         proceeding or has been named or is a subject of a criminal,
         governmental or other regulatory investigatory proceeding (excluding
         traffic violations);

                 (b) Neither the Company nor its Subsidiary nor, to their
         Knowledge, any employee thereof, has been or is the subject of any
         order, judgment or decree of any Governmental Authority or other
         regulatory body permanently or temporarily enjoining, barring,
         suspending or limiting it or any such person from engaging in any type
         of business or professional practice or activities; or

                 (c) Neither the Company nor its Subsidiary nor, to their
         Knowledge, any employee thereof, has been found by a court of competent
         jurisdiction in a civil action or by any Governmental Authority or
         other regulatory body to have violated any Law.

                 3.16 Compliance with Law. Neither the Company nor its
Subsidiary is subject to any judgment, order, writ, injunction or decree of any
Governmental Authority or arbitration tribunal. Except as set forth in Schedule
3.16, the Company and its Subsidiary has complied in all material respects with
and is not in default under, all Laws applicable to it, its operations,
properties, assets, products and services, the failure to comply with which
would have a material adverse effect on the Company or its Subsidiary. There is
no existing Law, and the Company is not aware of any proposed Law, which would
prohibit or materially restrict the Surviving



                                      -15-
<PAGE>

Corporation and its Subsidiary from, or otherwise materially adversely affect
the Surviving Corporation and its Subsidiary in, conducting the Business. Except
as set forth on Schedule 3.16, the Company has obtained, and as of the Closing
will have obtained, all requisite approvals and consents of, and made all
requisite filings with all Governmental Authorities and other third parties
which are necessary to be obtained or made to (i) permit the conduct of the
Business, (ii) permit the valid execution, delivery and performance by the
Company of this Agreement, including without limitation the Merger, and (iii)
prevent any Permit or agreement relating to the Business from terminating prior
to its scheduled termination as a result of the consummation of the transactions
contemplated hereby.

                 3.17 Labor and Employee Relations. Neither the Company nor its
Subsidiary is a party to or bound by any collective bargaining agreement with
any labor organization, group or association covering any of its employees, and
the Company has no Knowledge of any attempt to organize any of their employees
by any person, unit or group seeking to act as their bargaining agent. There are
no pending or, to the Company's Knowledge, threatened charges (by employees,
their representatives or governmental authorities) of unfair labor practices or
of employment discrimination or of any other wrongful action with respect to any
aspect of employment of any employee of the Company or its Subsidiary.

                 3.18 Certain Employees. Set forth on Schedule 3.18 is a list of
the names of all of the physicians, employees and consultants employed by or
under contract with the Company or its Subsidiary in connection with the
Business, together with the title or job classification of each such person and
his or her current compensation. Except as set forth on Schedule 3.18, none of
such persons has (i) an employment agreement, contract or understanding, whether
oral or written, with the Company or its Subsidiary which is not terminable on
thirty (30) days or less notice by the Company or its Subsidiary without cost or
other liability to the Company or its Subsidiary or (ii) a non-competition,
non-disclosure and/or non-solicitation agreement or understanding with the
Company or its Subsidiary, whether written or oral, and all such employment and
other agreements are set forth in Schedule 3.18 hereto. No person listed on
Schedule 3.18 has indicated that he or she intends to terminate his or her
employment with the Company or its Subsidiary or seek a material change in his
or her duties or status. Each person listed on Schedule 3.18 who is required to
be licensed by applicable state law in order to perform his or her duties is so
licensed. Set forth on Schedule 3.18 is the amount, if any, of any severance
liability of the Company or its Subsidiary with respect to each person listed on
Schedule 3.18.

                 3.19 Employee Benefits. Set forth on Schedule 3.19 is an
accurate and complete list of all plans within the meaning of the Employee
Retirement Income Security Act of 1974, as amended, 29 U.S.C. Section 1001 et
seq. ("ERISA") including, without limitation, all pension plans within the
meaning of ERISA Section 3(2)(A) ("Pension Plans"), deferred compensation, stock
purchase, stock option, incentive, bonus, vacation, severance, disability,
hospitalization, medical insurance, life insurance, fringe benefit, and other
employee benefit



                                      -16-
<PAGE>

plans within the meaning of ERISA Section 3(1) ("Welfare Plans"), and all
obligations, customary practices or programs and arrangements, whether formal or
informal, oral or written, and whether or not legally enforceable which the
Company, its Subsidiary or any entity that, together with the Company and/or its
Subsidiary would be treated as a single employer under Code Section 414 or ERISA
Section 4001(b) (an "ERISA Affiliate") sponsors, maintains, participates in,
contributes to or is obligated to contribute to or under which past or present
employees, directors, contractors, service providers, agents and representatives
of the Company, its Subsidiary or ERISA Affiliate(s) may be entitled to benefits
or the Company, its Subsidiary ERISA Affiliate(s) may have any liability
(collectively, the "Plans"). Through the Closing Date, all such Plans shall be
maintained by the Company or its Subsidiary in full force and effect. Neither
the Company, its Subsidiary nor any ERISA Affiliate contributes, has contributed
or has ever been required to contribute, to any plan subject to Title IV of
ERISA or to any multiemployer plan, as defined in section 3(37) or section
4001(a)(3) of ERISA and no withdrawal liability has been or may be assessed
under Title IV of ERISA against the Company, its Subsidiary or ERISA
Affiliate(s) based on circumstances existing on or prior to the Closing Date.

                 Each Plan has been established and administered in accordance
with its terms and in full compliance with the applicable provisions of the
Code, ERISA and other applicable laws, rules and regulations, and all
obligations of the Company, its Subsidiary and ERISA Affiliate(s) with respect
to each Plan have been satisfied. Each Plan which is intended to be qualified
within the meaning of section 401(a) of the Code is so designated on Schedule
3.19 and is so qualified and has received a favorable determination letter from
the IRS with respect to its qualification and no event has occurred which would
cause the loss of such qualification. Each Plan which is intended to meet the
requirements for tax-favored treatment under Subchapter D of Chapter 1 of
Subtitle A of the Code meets such requirements in all material respects.

                 With respect to each Plan, no actions, suits or claims (other
than claims for benefits in the ordinary course) are pending or threatened, and
no facts or circumstances exist which could give rise to any such actions, suits
or claims. No reportable event (as defined in ERISA Section 404 and its
regulations) has occurred. Neither the Company, its Subsidiary or the Founders
has engaged in a prohibited transaction, as defined under section 4975 of the
Code or section 406 of ERISA, with respect to any Plan, and, to the Company's
Knowledge, no fiduciary with respect to any Plan has breached any fiduciary duty
to such Plan under Part 4 of Title I of ERISA or other applicable law. No event
has occurred and no condition exists that has subjected or would subject the
Company, its Subsidiary or ERISA Affiliate(s) to any tax, fine or penalty
imposed by the Code, ERISA or other applicable law. All required contributions
have been made timely by the Company to each of the Plans and there is no
funding deficiency with respect to any of the Plans. All required insurance
premiums or other funding obligations have been timely made in full with respect
to the Plans. Each Plan may be amended or terminated in accordance with its
terms without obligation or liability, other than those obligations and
liabilities for which specific assets have been set aside or reserved for on the



                                      -17-
<PAGE>

balance sheet as of the Balance Sheet Date included in the Financial Statements
of the Company and those obligations and liabilities reflected by the terms of
the Plan documents. There are no unfunded obligations under any Plan providing
benefits to employees of the Company, its Subsidiary or ERISA Affiliate(s)
during employment or after termination of their employment. The consummation of
the Merger will not result in the payment, vesting or acceleration of any
benefit.

                 3.20 Insurance. The Company is, and will be through the Closing
Date, adequately insured with responsible insurers in respect of their
properties, assets and business against risks normally insured against by
companies in similar lines of business under similar circumstances. Schedule
3.20 correctly describes (by type, carrier, policy number, limits, premium and
expiration date) the insurance coverage carried by the Company and its
Subsidiary with respect to the Business, which insurance will remain in full
force and effect with respect to all events occurring prior to the Closing. The
Company and its Subsidiary (i) have not failed to give any notice or present any
claim under any such policy or binder in due and timely fashion, (ii) have not
received notice of cancellation or non-renewal of any such policy or binder,
(iii) are not aware of any threatened or proposed cancellation or non-renewal of
any such policy or binder and (iv) have not received notice of and are not
otherwise aware of any insurance premiums which will be materially increased in
the future. There are no outstanding claims under any such policy which have
gone unpaid for more than forty-five (45) days, or as to which the insurer has
disclaimed liability.

                 3.21 Transactions With Affiliates. Except as set forth in
Schedule 3.21 hereto and only with respect to transactions giving rise to
current or contingent liabilities of the Company or its Subsidiary, no current
or former holder of 5% or more of any class of capital stock of the Company or
its Subsidiary at the time such transaction was entered into, or any director,
officer or employee of the Company or its Subsidiary, or member of the family of
any such person, or any corporation, partnership, trust or other entity in which
any such person, or any member of the family of any such person, has an interest
or is an officer, director, trustee, partner or holder of any equity interest,
is a party to any transaction with the Company or its Subsidiary, including any
contract, agreement or other arrangement providing for the employment of,
furnishing of services by, rental of real or personal property from, or
otherwise requiring payments or involving other obligations to or from.

                 3.22 Taxes. The Company and its Subsidiary have filed all Tax
returns and reports required to be filed, including, without limitation, returns
and estimated returns and have paid in full all taxes shown due thereon and all
estimated Tax when due (together with all interest, penalties, assessments and
deficiencies assessed in connection therewith due through the date hereof,
whether or not shown on any Tax return). Neither the Company nor its Subsidiary
is required to pay any other Tax except as shown in such Tax returns, reports
and information filings. All such returns, reports and information filings
required to be filed, including any amendments to date, have been prepared in
good faith and without negligence or


                                      -18-
<PAGE>

misrepresentation and were correct and complete in all material respects. The
Company and its Subsidiary has either paid or, in accordance with GAAP applied
consistently with prior periods, adequately provided for, by reserves or other
proper accounting treatment shown in the records and books of account, its
liability for all Tax of every kind, for the current tax year and for all prior
years. The Company has no Knowledge of any proposed or threatened assessment or
reassessment of any Taxes. In addition, at the date hereof, the Company and its
Subsidiary have deducted and remitted all withholding tax or source deductions
when due to the appropriate governmental authority as required by Law or the
Company and its Subsidiary have adequately provided for such deductions by
reserves or other proper accounting treatment their books and records of
account. Neither the Company nor its Subsidiary (i) has executed any waiver to
extend, or otherwise taken or failed to take any action that would have the
effect of extending, the applicable statute of limitations with respect to its
Tax liabilities, (ii) is a "consenting corporation" within the meaning of
Section 341(f) of the Code, (iii) has been a member of any consolidated group
(other than with the Company and its Subsidiary) for Tax purposes or (iv) does
not have, or will fail to have, all records and information necessary for the
timely and accurate filing of any Tax returns due after the date hereof,
including any returns due after the Closing Date which relate to the period
prior to the Closing Date. Except as disclosed in Schedule 3.22, the Company has
been at all times taxable as a Subchapter S Corporation under the Code and has
filed all Tax returns consistent with this characterization. The Subsidiary is a
"Qualified Subchapter S Subsidiary" as defined under Section 1361(b)(3)(B) of
the Code, and the Company elected to treat the Subsidiary as such.

                 3.23 Brokers. Except as set forth on Schedule 3.23, no agent,
person or firm acting on behalf of the Company and its Subsidiary or under their
authority is or will be entitled to a financial advisory fee, brokerage
commission, finder's fee or like payment in connection with the transactions
contemplated hereby.

                 3.24 Environmental Laws.

                 (a) The Company and its Subsidiary have operated and continue
to operate the Centers and the Business in compliance in all material respects
with all Laws relating to (i) pollution or protection of the environment,
natural resources or human health from any Hazardous Substances (as hereinafter
defined) or (ii) nuisance, trespass or "toxic tort," including, without
limitation, Laws relating to emissions, discharges, releases or threatened
releases of any Hazardous Substance or otherwise relating to the manufacture,
processing, importation, distribution, use, generation, treatment, storage,
disposal, transportation or handling of any Hazardous Substance (collectively,
"Environmental Laws") where the failure to comply would have a material adverse
effect on the Company or its Subsidiary.

                 (b) To the Company's Knowledge, no Leased Premises nor any real
property contiguous thereto, is or has been designated by any state, local or
federal agency or body as



                                      -19-
<PAGE>

a hazardous waste disposal site or a site or location requiring investigation
concerning, or management, clean-up or removal of, any Hazardous Substance.

                 (c) There is no civil, criminal or investigative action, suit,
litigation, hearing, communication (written or oral), demand, claim, citation,
notice or notice of violation, warning, consent decree, judgment or order by any
Person or Governmental Authority alleging, claiming, concerning or finding
liability or potential liability arising out of, based on or resulting from, in
whole or in part, (a) the actual or alleged presence, threatened release,
release, emission, disposal, storage, treatment, transportation, generation,
manufacture or use of any Hazardous Substance at or from any location or (b)
circumstances forming the basis of any violation, or alleged violation, of any
Environmental Laws (collectively, "Environmental Claims"), pending or threatened
against the Company or its Subsidiary or against any Person whose liability for
any Environmental Claim the Company or its Subsidiary has or may have retained
or assumed either contractually or by operation of Law. There are no past or
present actions, activities, circumstances, conditions, events, incidents or
practices, including, without limitation, the release, threatened release,
emission, discharge, disposal, storage, treatment, transportation, generation,
manufacture or use of any Hazardous Substance that could form the basis of any
Environmental Claim against the Company or its Subsidiary or, to the Company's
Knowledge, against any Person whose liability for any Environmental Claim the
Company or its Subsidiary has or may have retained or assumed either
contractually or by operation of Law.

                 (d) All Waste (as hereinafter defined) generated in connection
with the Business, operations, Assets and properties of the Company and its
Subsidiary has been (i) treated, stored or disposed of by or at facilities duly
licensed pursuant to applicable Environmental Laws and (ii) transported to such
facilities by transporters duly licensed pursuant to applicable Environmental
Laws. The Company has maintained true and complete records relating to the
generation, transportation, treatment, storage and disposal of Waste generated
in connection with the business, operations, assets and properties of the
Company and its Subsidiary.

                 (e) The Company has delivered to PHMX all environmental
inspection reports ("Environmental Reports") prepared by any person or entity
concerning compliance with applicable Environmental Laws of the Company's
Business, operations, assets or properties or the use, manufacture, importation,
processing, storage, treatment, transportation, release or disposal therefrom,
therein or thereon of any Hazardous Substance. All such Environmental Reports
are listed on Schedule 3.24.

                 3.25 Accounts Receivable. All of the accounts receivable of the
Company and its Subsidiary shown or reflected on the Balance Sheet in the
Company Financial Statements, less the reserve for doubtful accounts in the
amount shown on such Balance Sheet, are valid and enforceable claims and subject
to no set off or counterclaim, except for adjustments based on revisions to
study participation and enrollment in accordance with the applicable Clinical
Trial


                                      -20-
<PAGE>

protocol. Except as set forth on Schedule 3.25, the Company has no accounts or
loans receivable from any of its directors, officers or employees.

                 3.26 SEC Filings. If PHMX is required by Nasdaq to seek the
approval of its stockholders prior to the consummation of the Merger, the
Company Financial Statements and other information relating to the Company
furnished in writing by the Company to PHMX for inclusion in the Proxy
Statement, at the time of the mailing of the Proxy Statement to PHMX's
stockholders and at the time of the meeting of PHMX's stockholders, will not
contain any untrue statement of a material fact or omit to state a material fact
concerning the Company or its Subsidiary or omit to state a material fact
required or necessary to be stated therein in order to make the statements
contained therein concerning the Company, in light of the circumstances under
which they are made, not misleading. Information relating to the Company and its
Subsidiary furnished in writing by the Company to PHMX for inclusion in any
registration statement or other voluntary or required filing pursuant to the
Securities Act or the Exchange Act (collectively, an "SEC Filing"), at the time
of filing with the SEC, will not contain any untrue statement of a material fact
or omit to state a material fact concerning the Company or its Subsidiary or
omit to state a material fact required or necessary to be stated therein in
order to make the statements contained therein concerning the Company or its
Subsidiary, in light of the circumstances under which they are made, not
misleading; except that the Company, the Founders, the Trustee and Mr. Heffernan
make no representation or warranty with respect to any statement, information or
omission relating to PHMX or its affiliates provided to the Company, the
Founders, the Trustee or Mr. Heffernan, either orally or in writing, for
inclusion in any SEC Filing.

                 3.27 Disclosure. All documents and schedules delivered or to be
delivered by or on behalf of the Company and its Subsidiary in connection with
this Agreement, the Merger and the transactions contemplated hereby are true,
complete and correct in all material respects. Neither this Agreement, nor any
Schedule or Exhibit to this Agreement contains any untrue statement of a
material fact or omits a material fact necessary to make the statements
contained herein or therein, in light of the circumstances in which made, not
misleading.

                                   ARTICLE IV
             REPRESENTATIONS AND WARRANTIES OF ACQUISITION AND PHMX

                 Acquisition and PHMX jointly and severally represent and
warrant to the Company as follows:

                 4.1 Organization. Acquisition is a corporation duly
incorporated, validly existing and in good standing under the laws of the State
of Delaware. PHMX is a corporation duly incorporated, validly existing and in
good standing under the laws of the State of Delaware. PHMX owns all of the
issued and outstanding shares of capital stock of Acquisition.


                                      -21-
<PAGE>

                 4.2 Power and Authority. Acquisition and PHMX each have full
corporate power and authority to carry on their businesses as now being
conducted and to own, operate and lease their respective properties in the
places where such businesses are now conducted and such properties are now
owned, leased or operated. This Agreement and the transactions contemplated
hereby have been duly approved by the Boards of Directors of Acquisition and
PHMX. Acquisition and PHMX each have full corporate power and authority to enter
into this Agreement and to consummate the transactions contemplated hereby, and
this Agreement and all other agreements to be executed and delivered by
Acquisition and PHMX in connection herewith constitute the legal, valid and
binding obligations of Acquisition and PHMX enforceable against them in
accordance with their respective terms.

                 4.3 No Violation. Neither the execution and delivery of this
Agreement and the other documents and instruments contemplated hereby, the
consummation of the transactions contemplated hereby or thereby, nor the
performance of this Agreement and such other documents and instruments in
compliance with the terms and conditions hereof and thereof will (i) conflict
with or result in any breach of any trust agreement, charter documents, by-law,
judgment, decree, order, statute or regulation applicable to Acquisition or
PHMX, (ii) require any consent, approval, authorization or permit of, or filing
with or notification to, any governmental or regulatory authority, (iii) result
in a breach of or default (or give rise to any right of termination,
cancellation or acceleration) under any Law or any of the terms, conditions or
provisions of any mortgage, indenture, note, license, agreement or other
instrument to which Acquisition or PHMX is a party or (v) violate any order,
writ, injunction, decree, statute, rule or regulation applicable to Acquisition
or PHMX.

                 4.4 SEC Reports. PHMX has previously made available to the
Company an accurate and complete copy of each final registration statement,
prospectus, report, schedule and definitive proxy statement (including any
amendment or supplement thereto) filed since January 23, 1996 by PHMX with the
SEC pursuant to the Securities Act or the Exchange Act (the "PHMX Reports"), and
no such PHMX Report contained as of its date of filing with the SEC any untrue
statement of a material fact or omitted, as of its date of filing with the SEC,
to state any material fact required to be stated therein or necessary in order
to make the statements therein, in light of the circumstances in which they were
made, not misleading, except that information as of a later date shall be deemed
to modify information as of an earlier date. Schedule 4.4 contains a complete
list of all PHMX Reports. Since January 29, 1996, PHMX has timely filed all
reports, registration statements and other filings required to be filed with the
SEC under the Securities Act and the Exchange Act.

                 4.5 Broker. Except as set forth on Schedule 4.5, no agent,
broker, person or firm acting on behalf of Acquisition or PHMX or under its
authority is or will be entitled to a financial advisory fee, brokerage
commission, finder's fee or like payment in connection with any of the
transactions contemplated hereby.


                                      -22-
<PAGE>

                 4.6 Proxy Statement. If a vote of the shareholders of PHMX is
required by Nasdaq prior to the Closing, the Proxy Statement to be mailed to
stockholders of PHMX in connection with the solicitation of proxies on behalf of
PHMX's Board of Directors for the meeting of stockholders of PHMX to be held to
seek the approval of this Agreement and the Merger (the "Proxy Statement"), at
the time of its mailing to such stockholders and at the time of such meeting,
will not contain any untrue statement of a material fact or omit to state a
material fact concerning PHMX or the Merger or omit to state a material fact
required or necessary to be stated therein in order to make the statements
contained therein concerning PHMX, or the Merger, in light of the circumstances
under which they are made, not misleading; except that, PHMX makes no
representation or warranty with respect to any statement, information or
omission relating to the Company or its affiliates provided to either orally or
in writing for inclusion in the Proxy Statement.

                 4.7 Disclosure. The representations and warranties made by
Acquisition and PHMX in this Agreement do not contain any untrue statement of a
material fact or omit to state a material fact necessary to make the statements
contained herein, in light of the circumstances in which they are made, not
misleading.

                 4.8 Form S-3. As of the date hereof, the Company is eligible
under the Securities Act to file a registration statement registering PHMX
Common Stock on Form S-3.

                                    ARTICLE V
                            COVENANTS OF THE COMPANY

                 The Company, each of the Founders, the Trustee and Mr.
Heffernan covenant and agree with Acquisition and PHMX as follows:

                 5.1 Best Efforts Cooperation. Until the Closing, the Company
shall use its best efforts in good faith to perform and fulfill, or cause to be
performed and fulfilled, all conditions and obligations to be fulfilled, or
performed by it hereunder, to the end that the transactions contemplated hereby
will be fully and timely consummated; provided, however, if and to the extent
that the Board of Directors of the Company determines in its good faith
judgment, based upon the written advice of outside counsel, that its fiduciary
duties under applicable Delaware Law require such action, the Company and each
officer, director, employee, consultant, advisor, agent or investment banker of
the Company and its Subsidiary may, in response to unsolicited requests, provide
information concerning the Company and the Business, and participate in
discussions and negotiate with any other corporation, partnership, person or
other entity or group concerning a proposal for any merger, sale of all or
substantially all of the assets of the Company, or other transaction involving
the transfer of effective control of the Company (an "Alternative Transaction").


                                      -23-
<PAGE>

                 5.2 Access. Until the Closing, the Company shall give
Acquisition and PHMX, and their attorneys, accountants and other authorized
representatives complete access, upon reasonable notice and at reasonable times,
to the Company's and its Subsidiary's offices, suppliers, employees, business
and financial records, contracts, business plans, budgets and projections,
agreements and commitments and other documents and information concerning the
Business and persons employed by or doing business with the Company and its
Subsidiary, except such documents covered by the attorney-client privilege. In
order that Acquisition and PHMX may have full opportunity to make such
examination and investigation as they may desire of the Business, the Company
and its Subsidiary will furnish Acquisition and PHMX and their representatives
during such period with all such information as such representatives may
reasonably request and cause the respective officers, employees, consultants,
agents, accountants and attorneys of the Company and its Subsidiary to cooperate
fully with the representatives of Acquisition and PHMX in connection with such
review and examination and to make full disclosure to Acquisition and PHMX of
all material facts affecting the Company's financial condition and the
operations, properties and prospects of the Business; provided, however, that
Acquisition and PHMX will, unless the Closing occurs, hold the documents and
information concerning the Company and the Business confidential in accordance
with Section 7.6 hereof.

                 5.3 Insurance. Until the Closing, the Company and its
Subsidiary shall maintain with financially sound and reputable insurers,
insurance against such casualties and contingencies and of such types and in
such amounts as is customary for companies similarly situated.

                 5.4 Compliance with Laws. Until the Closing, the Company shall
conduct the Business in compliance with all applicable Laws.

                 5.5 Keeping of Books and Records. Until the Closing, the
Company shall keep adequate records and books of account, in which complete
entries will be made in accordance with GAAP consistently applied, reflecting
all financial transactions and in which all proper reserves for depreciation,
depletion, obsolescence, amortization, taxes, bad debts and other purposes in
connection with the Business shall be made.

                 5.6 Conduct of Business. Prior to the Effective Time, unless
Acquisition shall have consented in writing thereto, the Company:

                 (a) shall, and shall cause its Subsidiary to, conduct its
         operations according to its usual, regular and ordinary course in
         substantially the same manner as heretofore conducted;

                 (b) shall use its reasonable efforts, and shall cause its
         Subsidiary to use its reasonable efforts, to preserve intact its
         business organization and goodwill, keep



                                      -24-
<PAGE>

         available the services of its officers and employees, and maintain
         satisfactory relationships with those persons having business
         relationships with it;

                 (c) shall not, and shall not permit its Subsidiary to, amend
         its Certificate of Incorporation or By-laws, except as provided for in
         this Agreement;

                 (d) shall promptly notify Acquisition of any material emergency
         or other material change in its or its Subsidiary's condition
         (financial or otherwise), business, properties, assets, liabilities,
         prospects or the Ordinary Course of Business of it or its Subsidiary or
         in the operation of its or its Subsidiary's properties and of any
         litigation or governmental complaints, investigations or hearings (or
         communications indicating that the same may be contemplated);

                 (e) shall not, and shall not permit its Subsidiary to, (i)
         except pursuant to the exercise of options, warrants, conversion rights
         and other contractual rights existing on the date hereof and listed on
         Schedule 3.3, issue any shares of its capital stock, effect any stock
         split or otherwise change its capitalization as it exists on the date
         hereof, (ii) grant, confer or award any option, warrant, conversion
         right or other right to acquire any shares of its capital stock not
         existing on the date hereof and listed on Schedule 3.3, (iii)
         accelerate the vesting or exercisability of any option, warrant,
         conversion right or other right to acquire any shares of its capital
         stock, (iv) increase, or permit any of its Subsidiary to increase, any
         compensation or enter into or amend any employment agreement with any
         of its present or future officers, directors or employees except for
         the payment of cash bonuses to officers, directors or employees
         pursuant to and consistent with existing plans or programs described on
         Schedules 3.18 and 3.19, (v) adopt any new employee benefit plan
         (including any stock option, stock benefit or stock purchase plan) or
         amend any existing employee benefit plan in any respect or (vi) sell,
         lease or otherwise dispose of any of its assets which are material,
         individually or in the aggregate, except in the Ordinary Course of
         Business;

                 (f) shall not, and shall not permit its Subsidiary to, (i)
         incur or obligate itself to incur any capital expenditure in excess of
         $50,000, incur any long-term indebtedness in addition to that
         outstanding on the date hereof or any other indebtedness or liability
         other than in the Ordinary Course of Business; (ii) make any loans,
         advances or capital contributions to, or investments in, any other
         person, other than travel or other advances to employees consistent
         with past practice; or (iii) assume, guarantee, endorse or otherwise
         become liable or responsible (whether directly, contingently, or
         otherwise) for the obligations of any other Person, except to endorse
         checks for collection or deposit in the Ordinary Course of Business;
         provided, however, that the Company is permitted to incur such
         indebtedness as is necessary to satisfy the Company's Subchapter S tax
         liability for the year ended December 31, 1996 and the Stub Period
         Subchapter S Tax Liability (as defined herein);


                                      -25-
<PAGE>

                 (g) declare or pay any dividend or distribution on any shares
         of its capital stock, other than with respect to and to the extent of
         the Company Shareholders' aggregate Subchapter S tax liability for the
         year ended December 31, 1996 and the Stub Period Subchapter S Tax
         Liability; or

                 (h) agree, or permit its Subsidiary to agree, in writing or
         otherwise to take any of the foregoing actions or any action that would
         make any representation or warranty in this Agreement untrue or
         incorrect as of the date hereof or as of the Effective Time, as if made
         as of such time.

                 5.7 Litigation. Until the Closing, the Company will promptly
notify Acquisition of any lawsuits, claims, proceedings or investigations which
are threatened or commenced against or by the Company and its Subsidiary or
their affiliates, or against any employee, consultant or director of the Company
or its Subsidiary.

                 5.8 Continued Effectiveness of Representations and Warranties.
From the date hereof up to and including the Closing Date, (i) the Company and
its Subsidiary will conduct the Business in a manner such that the
representations and warranties contained herein shall continue to be true and
correct on and as of the Closing Date as if made on and as of the Closing Date,
except for changes and events arising as a consequence of the Merger, or actions
in the Ordinary Course of Business after the date hereof which would not have an
adverse effect on the properties, assets, operations or condition (financial or
otherwise) or prospects of the Business; and (ii) the Company will advise
Acquisition promptly in writing of any condition or circumstance occurring from
the date hereof up to and including the Closing Date which could cause any
representations or warranties of the Company to become untrue.

                 5.9 No Negotiations. Until the Closing, or the earlier
termination of this Agreement in accordance with its terms, the Company and each
officer, director, employee, consultant, advisor, agent or investment banker of
the Company and its Subsidiary shall not, directly or indirectly, initiate,
solicit or continue discussions with, engage in negotiations with, or provide
any information to any corporation, partnership, person or other entity or group
involving the possible sale, directly or indirectly, transfer or joint venture
of any part of the Business or the stock or assets of the Company or its
Subsidiary to any person or entity other than Acquisition; provided, however, if
and to the extent that the Board of Directors of the Company determines in its
good faith judgment, based upon the written advice of outside counsel, that its
fiduciary duties under applicable Delaware law require such action, upon written
notice to PHMX, the Company and each officer, director, employee, consultant,
advisor, agent or investment banker of the Company and its Subsidiary may, in
response to unsolicited requests, provide information concerning the Company or
the Business, participate in discussions and negotiate with any other
corporation, partnership, person or other entity or group concerning an
Alternative Transaction.


                                      -26-
<PAGE>

                 5.10 Monthly Statements; Daily Census. Until the Closing, the
Company will deliver to PHMX (i) monthly financial statements for the Company
and each Center within thirty (30) days after the end of each month and (ii)
weekly patient census reports for each Center for the preceding business week.

                 5.11 Covenant Not To Compete. For a period of five (5) years
following the Closing Date, each of the Founders covenants and agrees that
neither of them nor any affiliate, directly or indirectly, (i) shall engage or
become interested in, as owner, employee, partner, through stock ownership
(except for ownership of less than one (1) percent interest of any class of
securities which are listed for trading on a national securities exchange),
investment of capital, lending of money or property, rendering of services or
otherwise, either alone or in association with others, in the operation,
management or supervision of any type of business or enterprise which is engaged
conduct substantially similar to the Business within one hundred (100) miles of
any Center or any future facility or location at which PHMX or the Surviving
Corporation conduct the Business or (ii) solicit any employee of the Business
employed (other than an executive officer of the Company) to leave the Company's
employ or negotiate for the employment of any such employee. Notwithstanding the
foregoing, nothing contained in this Section 5.11 shall prohibit either of the
Founders from (i) engaging in academic research and writing, whether or not he
receives compensation therefor, involving reviewing, analyzing and interpreting
the results of clinical tests performed by others solely for publication in
scholarly journals; provided, however, that under no circumstances may either
Founder be actively or passively involved in the conduct of any Clinical Trials
in competition with PHMX or any of its subsidiaries, including, without
limitation, the Surviving Corporation, (ii) undertaking the clinical testing of
a medical or therapeutic device developed or conceived by the Founders.

                 5.12 Non-Disturbance Agreements. The Company shall use its best
efforts to obtain and deliver to Acquisition at the Closing non-disturbance
agreements executed and delivered by each mortgagee of each Leased Premises
listed on Schedule 3.11, in form and substance satisfactory to Acquisition.

                 5.13 Further Assurances. The Company will use its best efforts
to have all present officers and directors of the Company and its Subsidiary
execute whatever minutes of meetings or other instruments and take whatever
action as may be necessary or desirable to effect, perfect or confirm of record
of otherwise, in the Surviving Corporation, full right, title and interest in
and to the Business, properties and assets now conducted or owned by the
Company, free and clear of all restrictions, liens, encumbrances, rights, title
and interests in others, or to collect, realize upon, gain possession of, or
otherwise acquire full right, title and interest in and to such business,
properties and assets, or to carry out the intent and purposes of the
transactions contemplated hereby.


                                      -27-
<PAGE>

                 5.14 Certain Agreements. Neither the Company nor its Subsidiary
will agree to do or cause to be done any of the acts which the Company has
covenanted not to do under this Article V.

                 5.15 Pension, Profit Sharing and other Retirement Plans. The
Company shall have commenced the termination or suspension of its Plans.

                                   ARTICLE VI
                        COVENANTS OF ACQUISITION AND PHMX

                 6.1 Best Efforts Cooperation. Acquisition and PHMX covenant and
agree that they shall use their best efforts in good faith to perform and
fulfill all conditions and obligations to be fulfilled or performed by them
hereunder to the end that the transactions contemplated hereby will be fully and
timely consummated.

                 6.2 Registration of PHMX Common Stock. In accordance with and
subject to the terms of the Registration Agreement and the Shareholder Agreement
(as defined herein), PHMX covenants and agrees to file with the SEC within two
(2) business days following the Closing Date a Registration Statement on Form
S-3 concerning the resale of the Merger Consideration and to use its best
efforts to diligently pursue the registration of the resale of the Merger
Consideration with the SEC under the Securities Act.

                 6.3 Special Report on Form 8-K. Upon consummation of the
Merger, promptly following the first calendar month of combined operations of
the Company and PHMX (the "Combined Operations"), but in no event more than
forty-five (45) days after such calendar month, PHMX shall file a Special Report
on Form 8-K (the "Special Report") with the SEC reporting the results of the
Combined Operations; provided, however, that if pursuant to this Section 6.3,
PHMX would be obligated to file a Special Report less than two (2) weeks prior
to its filing with the SEC of a Quarterly Report on Form 10-Q, then PHMX may, at
its option, file the results of the Combined Operations on such Quarterly Report
on Form 10-Q in lieu of the Special Report, and shall thereby be deemed to have
satisfied its obligations pursuant to this Section 6.3.



                                      -28-
<PAGE>

                                   ARTICLE VII
                                MUTUAL COVENANTS

                 7.1 General Covenants. Following the execution of this
Agreement, Acquisition, PHMX and the Company agree:

                 (a) If any event should occur, either within or without the
         knowledge or control of any party, which would prevent fulfillment of
         the conditions to the obligations of any party hereto to consummate the
         transactions contemplated by this Agreement, to use its or their
         reasonable efforts to cure the same as expeditiously as possible;

                 (b) To cooperate fully with each other in preparing, filing,
         prosecuting, and taking any other actions which are or may be
         reasonable and necessary to obtain the consent of any governmental
         instrumentality or any third party to accomplish the transactions
         contemplated by this Agreement;

                 (c) To deliver such other instruments of title, certificates,
         consents, endorsements, assignments, assumptions and other documents or
         instruments, in form reasonably acceptable to the party requesting the
         same and its counsel, as may be reasonably necessary to carry out
         and/or to comply with the terms of this Agreement and the transactions
         contemplated herein;

                 (d) To confer on a regular basis with the other, report on
         material operational matters and promptly advise the other orally and
         in writing of any change or event resulting in, or which, insofar as
         can reasonably be foreseen could result in, a Material Adverse Change
         on such party or which would cause or constitute a material breach of
         any of the representations, warranties or covenants of such party
         contained herein;

                 (e) To file all reports required to be filed by each of them or
         their affiliates with the Commission between the date hereof and the
         Closing Date and to deliver to the other (or its counsel) copies of all
         such reports promptly after the same are filed; and

                 (f) To promptly provide the other (or its counsel) with copies
         of all other filings made by such party with any state or federal
         governmental entity in connection with this Agreement or the
         transactions contemplated hereby.

                 7.2 Proxy Statement. Following the execution of this Agreement
and if PHMX is required by Nasdaq to seek shareholder approval of the Merger,
Acquisition, PHMX, the Company, the Founders and Mr. Heffernan agree:

                 (a) PHMX shall use its best efforts in good faith to prepare
         and file with the SEC, within thirty (30) days after the date hereof,
         the Proxy Statement;


                                      -29-
<PAGE>

                 (b) PHMX, Acquisition and the Company shall take any action
         required to be taken under the Delaware Law and the laws, rules and
         regulations of the SEC in connection with the consummation of the
         transactions contemplated by this Agreement;

                 (c) The Company, each of the Founders and Mr. Heffernan shall
         cooperate in the preparation and filing of the Proxy Statement and all
         information furnished for use therein by either party shall be
         reasonably satisfactory to the other; provided, however, that neither
         party shall have any liability to the other or to any third party for
         any information contained therein which is furnished in writing by the
         other party for inclusion in the Proxy Statement;

                 (d) Prior to the approval of the Merger by PHMX's shareholders,
         the Company shall correct any material information provided by it to be
         used in the Proxy Statement that shall have become false or misleading
         in any material respect and PHMX shall take all steps necessary to file
         with the SEC and have cleared by the SEC any amendment or supplement to
         the Proxy Statement and to cause the same as so corrected to be
         disseminated to the shareholders of PHMX, to the extent required by
         applicable law; provided, however, that prior to the dissemination
         thereof, (i) PHMX and the Company shall consult with each other with
         respect to such amendment or supplement and (ii) PHMX shall afford the
         Company with a reasonable opportunity to comment on disclosure relating
         to the Company or its affiliates and shall ensure that such disclosure
         is reasonably satisfactory to the Company; and

                 (e) PHMX and the Company shall promptly furnish to each other
         all information, and take such other actions as may reasonably be
         requested in connection with any action by either of them in
         furtherance of the provisions of this Section 7.2.

                 7.3 Shareholder Approval. If PHMX is required by Nasdaq to seek
shareholder approval of this Agreement and the Merger, PHMX shall promptly
submit this Agreement and the transactions contemplated herein for the approval
of its shareholders at a meeting of shareholders. Subject to the fiduciary
duties of the Board of Directors of PHMX under applicable law, the Board of
Directors of PHMX has agreed to recommend to its shareholders approval of the
Merger.

                 7.4 Public Announcements. PHMX, Acquisition and the Company
will consult with each other before issuing, and provide each other the
opportunity to review and comment upon, any press release or other public
statements with respect to the transactions contemplated by this Agreement,
including the Merger, and shall not issue any such press release or make any
such public statement prior to such consultation, except as may be required by
applicable law (including any fiduciary duty of disclosure), court process or
the rules and regulations of The National Market. The parties agree that the
initial press release or releases to be issued with



                                      -30-
<PAGE>

respect to the transactions contemplated by this Agreement shall be mutually
agreed upon prior to the issuance thereof.

                 7.5 Confidentiality. As used herein, "Confidential Information"
means any information or data that a party has acquired from another party that
is confidential or not otherwise available to the public, whether oral or
written, including without limitation any analyses, computations, studies or
other documents prepared from such information or data by or for the directors,
officers, employees, agents or representatives of such party (collectively, the
"Representatives"), but excluding information or data which (i) the party can
demonstrate it lawfully obtained or developed prior to January 1, 1997, (ii)
became available to the public other than as a result of such party's violation
of this Agreement, (iii) became available to such party from a source other than
the other party if that source was not bound by a confidentiality agreement with
such other party and such source lawfully obtained such information or data, or
(iv) is required to be disclosed by applicable law, provided that promptly after
being compelled to disclose any such information or data, the party being so
compelled shall provide prompt notice thereof to the other party so that such
other party may seek a protective order or other appropriate remedy. Each party
covenants and agrees that it and its Representatives shall keep confidential and
shall not disclose any Confidential Information, except to its Representatives
and lenders who need to know such information and agree to keep it confidential.
Each party shall be responsible for any breach of this provision by its
Representatives. In the event that the Closing does not occur, each party will
promptly return to the other all copies of such other party's Confidential
Information.

                 7.7 Additional Covenants of the Founders, Mr. Heffernan and the
Trustee.

                 (a) Between the date hereof and the Closing Date, none of Dr.
Brown, Dr. Rothman, Mr. Heffernan or the Trustee shall sell or dispose or agree
to sell or dispose in any manner of any shares of Company Common Stock owned
directly or indirectly by such Founder as of the date hereof.

                 (b) Each of Dr. Brown, Dr. Rothman, Mr. Heffernan and the
Trustee hereby agrees to vote such Founder's respective shares of Company Common
Stock in favor of the Merger, at a meeting of the Company Shareholders to
approve the Merger or by written consent in accordance with Delaware Law, and
prior or subsequent thereto shall take such other and further action as may be
necessary or desirable to effectuate the Merger and the other transactions
contemplated by the Agreement.


                                      -31-
<PAGE>

                                  ARTICLE VIII
                CONDITIONS TO PHMX' AND ACQUISITION'S OBLIGATIONS

                 The obligation of Acquisition and PHMX to consummate the
transactions contemplated hereby is subject to the satisfaction, on or before
the Closing Date, of the following conditions each of which may be waived by
Acquisition in its sole discretion.

                 8.1 Representations and Warranties True. All of the
representations and warranties of the Company, Heffernan, the Founders and the
Trustee contained in this Agreement or in any Schedules or other documents
attached hereto or referred to herein or delivered pursuant hereto or in
connection with the transactions contemplated hereby qualified by materiality
shall be true, correct and complete and those not so qualified shall be true,
correct and complete in all material respects on and as of the date hereof and
on and as of the Closing Date, as if made on and as of the Closing Date. On the
Closing Date, the Chairman of the Board or President of the Company shall have
executed and delivered to Acquisition a certificate, in form and substance
satisfactory to Acquisition and its counsel, to such effect.

                 8.2 Performance. The Company, Heffernan, the Founders and the
Trustee shall have performed and complied with all covenants and agreements
contained herein required to be performed or complied with by them prior to or
at the Closing Date. The Chairman of the Board or President of the Company shall
have executed and delivered to Acquisition a certificate, in form and substance
satisfactory to Acquisition and its counsel, to such effect and to the further
effect that all of the conditions set forth in this Article VIII have been
satisfied.

                 8.3 Consents. The Company, Heffernan, the Founders and the
Trustee shall have obtained all requisite approvals and consents of, and made
all requisite filings with, all Governmental Authorities and third parties which
are necessary to be obtained or made to (i) permit the valid execution, delivery
and performance by the Company of this Agreement, including, without limitation,
the Merger, and (ii) prevent any Permit or agreement relating to the Business
from terminating prior to its scheduled termination as a result of the
consummation of the transactions contemplated hereby. In addition, Acquisition
and PHMX shall have received or obtained all Permits from any Governmental
Authority or any third party necessary as a result of the Merger, and any appeal
period with respect to the same shall have expired without an objection thereto
having been filed.

                 8.4 No Material Adverse Change. No Material Adverse Change with
respect to the Company or its Subsidiary shall have occurred or be threatened.

                 8.5 No Actions, Suits or Proceedings. As of the Closing Date,
no action, suit, investigation or proceeding brought by any Governmental
Authority shall be pending or, to the knowledge of the parties to this
Agreement, threatened, before any Governmental Authority (i) to restrain,
prohibit, restrict or delay, or to obtain damages or a discovery order in
respect of


                                      -32-
<PAGE>

this Agreement or the consummation of the of the Merger, (ii) which has resulted
or may result in a Material Adverse Change with respect to the Company or its
Subsidiary or (iii) which has or may adversely affect the operation of the
Business or has or may result in the imposition of liability on the Company or
its Subsidiary. No order, decree or judgment of any Governmental Authority shall
have been issued and remain in effect at the Closing restraining, prohibiting,
restricting or delaying, the consummation of the transactions contemplated by
this Agreement. No insolvency proceeding of any character including, without
limitation, bankruptcy, receivership, reorganization, dissolution or arrangement
with creditors, voluntary or involuntary, affecting the Company or its
Subsidiary shall be pending, and neither the Company nor its Subsidiary shall
have taken any action in contemplation of, or which would constitute the basis
for, the institution of any such proceedings.

                 8.6 Opinion of Counsel. PHMX shall have received the opinion of
counsel to the Company by a law firm satisfactory to PHMX in the form set forth
as Exhibit 8.6 hereto.

                 8.7 Accountants. Acquisition shall have received from the
Company's independent public accountants, a certificate or letter, dated the
Closing Date, or, in the case of Sansiveri, Kimball & McNamee, L.L.P., dated
subsequent to the date hereof, but no later than the Closing Date, to the effect
that, such accountants will consent to the inclusion or incorporation of its
report on the audited financial statements of the Company for the years ended
December 31, 1994, 1995 and 1996 in any SEC Filing, subject to such accountants
normal due diligence procedures for such a consent.

                 8.8 SEC Determination of Pooling of Interests. Acquisition
shall have received the prior written approval of the SEC to the effect that the
Merger will qualify for "pooling of interests" accounting treatment in
accordance with the applicable accounting requirements, rules and regulations of
the SEC (the "Pooling Approval").

                 8.9 Approval of Acquisition and Its Counsel. All actions,
proceedings, consents, instruments and documents required to be delivered by, or
at the behest or direction of, the Company hereunder or incident to its
performance hereunder, and all other related matters, shall be reasonably
satisfactory as to form and substance to Acquisition and its counsel.

                 8.10 Closing Documents. The Company shall have delivered all of
the resolutions, certificates, documents and instruments required by this
Agreement, including without limitation:

                 (a) Resolutions of the Boards of Directors and shareholders of
         the Company, certified by the Secretary of the Company, and other
         evidence satisfactory to Acquisition that the requisite consent of the
         Board of Directors and the Company Shareholders has been obtained;


                                      -33-
<PAGE>

                 (b) Certificates of Good Standing with respect to the Company
         and its Subsidiary issued by the Secretary of State of its state of
         incorporation and of any state where it is qualified to do business as
         a foreign corporation;

                 (c) Copies of the charter documents and By-laws of the Company
         and its Subsidiary certified by the Secretary of State of its state of
         incorporation and by its secretary;

                 (d) Resignations of all officers and directors of the Company
         and its Subsidiary effective as of the Effective Time; and

                 (e) Estoppel Certificates from the lessors under each of the
         Leases in form and substance satisfactory to Acquisition.

                 8.11 Fairness Opinion. PHMX shall have received the written
opinion of Wessels, Arnold & Henderson, L.L.C. addressed to the Board of
Directors of PHMX prior to the Closing to the effect that, as of the date of
such opinion, the Merger Consideration is fair from a financial point of view to
PHMX, and as of the Closing Date, such opinion shall not have been withdrawn.

                 8.12 Corporate Approvals. This Agreement and the Merger
contemplated hereby shall have been approved by the Board of Directors of PHMX
by no later than July 24, 1997 and, if required by The Nasdaq National Market,
by a vote of the stockholders of PHMX.

                 8.13 Dissenting Shareholders. Holders of shares of Company
Common Stock representing nine percent (9.0%) or more of the outstanding shares
of Company Common Stock shall not have demanded appraisal for their shares in
accordance with Delaware Law.

                 8.14 Minimum Net Worth. On the Closing Date, the Company and
its Subsidiary shall have a combined net worth of not less than $4,888,370 plus
income earned from the period beginning January 1, 1997 through the Closing Date
(the "Stub Period"), less (i) the Company Shareholders' aggregate Subchapter S
tax liability, (which Subchapter S tax liability shall not exceed $1,800,000 for
the year ended December 31, 1996), (ii) the actual tax liability incurred by the
Founders, Heffernan and the beneficiaries of the Trusts for the Stub Period (the
"Stub Period Subchapter S Tax Liability") and (iii) the Deductible Expenses;
provided, however, that if the Deductible Expenses exceed $8,955,362, the
Aggregate Share Pool shall be reduced by a number equal to the amount by which
the Deductible Expenses exceed $8,955,362 divided by the ACPPS; provided,
however, that if the Deductible Expenses are less than $8,955,362, the Aggregate
Share Pool shall be increased by a number equal to the amount by which the
Deductible Expenses are less than $8,955,362 divided by the ACPPS.


                                      -34-
<PAGE>

                 8.15 Mendels Release. PHMX, Acquisition and the Company shall
have received a full and complete release from Dr. Joseph Mendels ("Mendels")
and CNS Consultants, Ltd., a Pennsylvania corporation ("CNS"), for any claim
from the beginning of time through the Merger and the Closing thereof arising
from any agreement, either orally or in writing, between or among any party to
this Agreement and Mendels and CNS.


                                   ARTICLE IX
                     CONDITIONS TO THE COMPANY'S OBLIGATIONS

                 The obligation of the Company to consummate the transactions
contemplated hereby is subject to the satisfaction, on or before the Closing
Date, of the following conditions, each of which may be waived by the Company in
its sole discretion:

                 9.1 Representations and Warranties to be True and Correct. The
representations and warranties contained in Article IV shall be true, complete
and correct, on and as of the Closing Date, as if made on and as of such date,
and Acquisition shall have delivered to the Company a certificate, in form and
substance satisfactory to the Company and its counsel, to such effect.

                 9.2 No Actions, Suits or Proceedings. As of the Closing Date,
no action, suit, investigation or proceeding brought by any governmental agency
or instrumentality shall be pending or, to the knowledge of the parties to this
Agreement, threatened, before any court or governmental body to restrain,
prohibit, restrict or delay, or to obtain damages or a discovery order in
respect of this Agreement or the consummation of the transactions contemplated
hereby. No order, decree or judgment of any court or governmental body shall
have been issued and remain in effect at the Closing restraining, prohibiting,
restricting or delaying, the consummation of the transactions contemplated by
this Agreement. No insolvency proceeding of any character including without
limitation, bankruptcy, receivership, reorganization, dissolution or arrangement
with creditors, voluntary or involuntary, affecting Acquisition shall be
pending, and Acquisition shall not have taken any action in contemplation of, or
which would constitute the basis for, the institution of any such proceedings.

                 9.3 Opinion of Acquisition's Counsel. The Company shall have
received from Nutter, McClennen & Fish, LLP, an opinion dated as of the Closing
Date substantially in the form of Exhibit 9.3 hereto.

                 9.4 Performance. Acquisition shall have performed and complied
with all agreements contained herein required to be performed or complied with
by it prior to or at the Closing Date, and Acquisition shall have delivered a
certificate to the Company, in form and substance reasonably satisfactory to the
Company and its counsel to such effect.


                                      -35-
<PAGE>

                 9.5 Closing Documents. Acquisition shall have delivered all of
the resolutions, certificates, documents and instruments required to be
delivered by it by this Agreement, including the Registration Agreement.

                 9.6 Approval of the Company and their Counsel. All actions,
proceedings, consents, instruments and documents required to be delivered by, or
at the behest or direction of, Acquisition hereunder or incident to its
performance hereunder, and all other related matters, shall be reasonably
satisfactory as to form and substance to the Company and its counsel.

                 9.7 No Material Adverse Change. No Material Adverse Change with
respect to PHMX shall have occurred or be threatened.

                 9.8 Employees of the Company. In connection with the employment
by PHMX of certain employees of the Company following the Closing, the
Compensation Committee of PHMX shall have approved, contingent upon the Closing,
the grant of incentive stock options to the individuals, in the amounts and
subject to the terms set forth on Exhibit 9.8 and all such options shall be
granted by the Company at the Effective Time.


                                    ARTICLE X
                                MUTUAL CONDITIONS

                 The respective obligation of each party to effect the Merger
shall be subject to the satisfaction at or prior to the Effective Time of the
following conditions:

                 10.1 No Injunctions or Restraints; Illegality. No order,
injunction or decree issued by any court or agency of competent jurisdiction or
other legal restraint or prohibition preventing the consummation of the Merger
or any of the transactions contemplated by this Agreement shall be in effect. No
statute, rule, regulation, order, injunction or decree shall have been enacted,
entered, promulgated or enforced by any Governmental Entity which prohibits,
restricts or makes illegal consummation of the Merger or any of the transactions
contemplated by this Agreement.

                 10.2 Pooling of Interests. Acquisition and the Company shall
have received a letter from Coopers & Lybrand, L.L.P. & Deloitte & Touche LLP,
respectively, dated not earlier than five (5) days prior to the Closing Date, to
the effect that the Merger will qualify for "pooling of interests" accounting
treatment in accordance with GAAP and the applicable requirements of the SEC.

                 10.3 Shareholder Agreement. Each of the Company Shareholders
shall enter into an agreement in the form attached hereto as Exhibit 10.3 (the
"Shareholder Agreement"), prior to the delivery of the Merger Consideration,
providing, among other things, that such


                                      -36-
<PAGE>

Company Shareholder shall not sell any shares of PHMX Common Stock acquired
pursuant to this Agreement until the results of the first thirty (30) days
combined operations of PHMX and the Company have been filed with the SEC
following the Closing and that such Company Shareholder is an "accredited
investor" as such term is defined in Rule 501(a) of the Securities Act.

                 10.4 Registration of Merger Consideration Post-Closing. If, as
of the Closing Date, the issuance of the shares of PHMX Common Stock pursuant to
this Agreement are not registered under the Securities Act, PHMX and each
Company Shareholder shall enter into a registration agreement, in the form
attached hereto as Exhibit 10.4 (the "Registration Agreement"), granting to each
Company Shareholder demand and piggyback registration rights with respect to the
Merger Consideration on a registration statement on Form S-3 under the
Securities Act.

                 10.5 No Material Adverse Economic Event. There shall not have
occurred (i) any general suspension of trading in, or limitation on prices for,
or other extraordinary event affecting securities on the New York Stock Exchange
or The Nasdaq National Market, (ii) a declaration of a banking moratorium or any
suspension of payments in respect of banks in the United States, (iii) any
material limitation (whether or not mandatory) by any Governmental Authority on,
or any other event which might affect the extension of credit by, lending
institutions, or (iv) in the case of any of the foregoing existing on the date
hereof, a material acceleration or worsening thereof.


                                   ARTICLE XI
                                    SURVIVAL

                 Notwithstanding any investigation made by any party to this
Agreement, all covenants, agreements, representations and warranties (a) in
Article III made by any of the Company, its Subsidiary, each Founder, the
Trustee and Mr. Heffernan and (b) in Article IV made by any of PHMX and
Acquisition, shall survive the Closing or the termination of this Agreement
until thirty (30) days following the completion of the audit of the Company's
1997 fiscal year by the independent public accountants of PHMX (the "1997
Audit"). No representation, warranty and agreement of the parties set forth in
this Agreement or any of the rights and remedies of the other party for any one
or more breach thereof shall survive subsequent to thirty (30) days following
the completion of the 1997 Audit.



                                      -37-
<PAGE>

                                   ARTICLE XII
                                 INDEMNIFICATION

                 12.1 Indemnification by the Company, the Founders, the Trustee
and Mr. Heffernan.

                 (a) Subject to the limits set forth in this Article XII and
solely with respect to matters asserted (even though not resolved) within the
period specified in Article XI, each of the Founders, the Trustee and Mr.
Heffernan, and, if the Merger is not consummated by the Termination Date, the
Company and its Subsidiary, jointly agree to indemnify, defend and hold PHMX and
Acquisition (each a "Indemnified PHMX Party") harmless from and in respect of
any and all Adverse Consequences that such Indemnified PHMX Party may suffer
through and after the date of the claim for indemnification arising out of or
due to any of the below-listed items up to an amount equal to the number of
shares of PHMX Common Stock issued to the Company Shareholders pursuant to this
Agreement multiplied by the Average Closing Price Per Share; provided, however,
that there shall be no limit as to the amount for which indemnification may be
sought with respect to any Taxes unpaid by the Company or any act of fraud by
the Company, the Founders, the Trustee or Mr. Heffernan. Liability among each of
the Founders, the Trustee and Mr. Heffernan, pursuant to this Article XII, shall
be pro rata based upon the number of shares of PHMX Common Stock received or to
be received pursuant to this Agreement. The items for which PHMX and Acquisition
shall be entitled to indemnification under Section 12.1(a) are:

                 (i) the inaccuracy of any representation contained herein or
         the breach of any warranty contained herein in each case made as of the
         date of this Agreement by the Company, any of its Subsidiary, or any of
         the Founders, including any inaccuracy in the Schedules delivered by
         the Company and the Founders pursuant to Article III hereof (the "CSL
         Disclosure Schedule") or omission of a fact from the CSL Disclosure
         Schedule that would be necessary to make the CSL Disclosure Schedule
         not misleading;

                 (ii) the inaccuracy of any representation contained herein or
         the breach of any warranty contained herein in each case made as of the
         Closing Date by the Company or its Subsidiary, including any inaccuracy
         in the CSL Disclosure Schedule or omission of a fact from the CSL
         Disclosure Schedule that would be necessary to make the CSL Disclosure
         Schedule not misleading, if the facts underlying such inaccuracy or
         breach (had they been disclosed) would been sufficient, individually or
         in the aggregate with the facts underlying all other such breaches,
         inaccuracies or omissions, to cause a failure of a closing condition
         set forth in any of subsections 8.1 or 8.2; and

                 (iii) the breach of any covenant, undertaking or agreement of
         the Company or its Subsidiary contained in this Agreement, which breach
         has not been cured within fifteen (15) days after the Company's receipt
         of written notice thereof from the


                                      -38-
<PAGE>


         Indemnified PHMX Party (or, if such breach is not reasonably capable of
         cure within fifteen (15) days, within a reasonable time under the
         circumstances (not to exceed forty-five (45) days, provided that the
         Company is making diligent efforts to effect such cure);

provided, however, that the Company, the Subsidiary, the Founders, the Trustee
and Mr. Heffernan shall have no obligation to indemnify an Indemnified PHMX
Party from, against or in respect of any Adverse Consequences until such
Indemnified PHMX Party has suffered Adverse Consequences by reason of all
breaches and other indemnified matters aggregating in excess of $100,000 (the
"Threshold Amount"), but if and at all times after an Indemnified PHMX Party has
suffered Adverse Consequences aggregating in excess of the Threshold Amount, the
Company, its Subsidiary and the Founders, the Trustee and Mr. Heffernan shall
indemnify the Indemnified PHMX Party for the full amount of such Adverse
Consequences incurred above and beyond the Threshold Amount.

                 12.2 Indemnification by PHMX.

                 (a) Subject to the limits set forth in this Article XII and
solely with respect to matters asserted (even though not resolved) within the
period specified in Article XI, PHMX agrees to indemnify, defend and hold the
Company, the Founders, the Trustee and Mr. Heffernan (each a "Indemnified CSL
Party") harmless from and in respect of any and all actual Adverse Consequences
that such Indemnified CSL Party may suffer through and after the date of the
claim for indemnification arising out of or due to any of the below-listed items
up to an amount equal to the number of shares of PHMX Common Stock issued to the
Company Shareholders pursuant to this Agreement multiplied by the Average
Closing Price per share. The items for which the Company, the Founders, the
Trustee and Mr. Heffernan shall be entitled to indemnification under Section
12.2(a) are:

                 (i) the inaccuracy of any representation contained herein or
         the breach of any warranty contained herein in each case made as of the
         date of this Agreement by PHMX or Acquisition, including any inaccuracy
         in the Schedules delivered by PHMX or Acquisition pursuant to Article
         IV hereof (the "PHMX Disclosure Schedule") or omission of a fact from
         the Disclosure Schedule that would be necessary to make the Disclosure
         Schedule not misleading;

                 (ii) the inaccuracy of any representation contained herein or
         the breach of any warranty contained herein in each case made as of the
         Closing Date by PHMX or Acquisition, including any inaccuracy in the
         PHMX Disclosure Schedule or omission of a fact from the Disclosure
         Schedule that would be necessary to make the Disclosure Schedule not
         misleading, if the facts underlying such inaccuracy or breach (had they
         been disclosed) would been sufficient, individually or in the aggregate
         with the facts underlying all other such breaches, inaccuracies or
         omissions, to cause a failure of a closing condition set forth in any
         of subsections 9.1 or 9.2; and



                                      -39-
<PAGE>

                 (iii) the breach of any covenant, undertaking or agreement of
         PHMX or Acquisition contained in this Agreement, which breach has not
         been cured within fifteen (15) days after PHMX' receipt of written
         notice thereof from the Indemnified CSL Party (or, if such breach is
         not reasonably capable of cure within fifteen (15) days, within a
         reasonable time under the circumstances (not to exceed forty-five (45)
         days, provided that PHMX is making diligent efforts to effect such
         cure);

provided, however, that PHMX shall have no obligation to indemnify an
Indemnified CSL Party from, against or in respect of any Adverse Consequences
until such Indemnified CSL Party has suffered actual Adverse Consequences by
reason of all breaches and other indemnified matters aggregating in excess of
$100,000 (the "Threshold Amount"), but if and at all times after an Indemnified
CSL Party has suffered actual Adverse Consequences aggregating in excess of the
Threshold Amount, PHMX shall indemnify the Indemnified CSL Party for the full
amount of such actual Adverse Consequences incurred above and beyond the
Threshold Amount.

                 12.3 Indemnification Procedures.

                 (a) An Indemnified CSL Party or an Indemnified PHMX Party (each
an "Indemnified Party") seeking indemnification pursuant to this Article XII
shall give notice to the party from whom such indemnification is sought (the
"Indemnifying Party") specifying in reasonable detail the basis for and the
indemnification sought and the amount of Adverse Consequences suffered by the
Indemnified Party. Not less than twenty (20) business days after receipt of such
demand from the Indemnified Party, the Indemnifying Party shall notify the
Indemnified Party in writing whether it agrees that indemnification is required
pursuant to this Article XII and whether it agrees with the Indemnified Party's
calculation of its Adverse Consequences. If following the receipt of such
response the parties continue to disagree, each party shall be free to seek any
remedy available to it at law or in equity. If the parties contest a claim for
indemnification in any adjudicatory proceeding, all Expenses of the prevailing
party or parties shall be borne by the other party or parties.

                 (b) An Indemnified Party's knowledge prior to Closing of any
inaccuracy or breach of any representation, warranty or covenant made or to be
performed by the Company, the Subsidiary, the Founders or Mr. Heffernan shall
not limit the Indemnified Party's rights to indemnification under this Agreement
if the Merger is consummated.

                 (c) The items or matters set forth on each section of the CSL
Disclosure Schedule and the PHMX Disclosure Schedule (collectively, the
"Disclosure Schedule"), or excepted by the text of a given representation or
warranty, shall qualify or be excepted from only the representations and
warranties contained in the Section of this Agreement to which such Disclosure
Schedule section specifically applies or in which such exception is written, and
such disclosure or exception of said item or matter shall not constitute a
disclosure or exception for



                                      -40-
<PAGE>

purposes of any other Section of this Agreement unless specifically referenced
in such other Section.

                 12.4 Indemnification Concerning Mendels. Notwithstanding
anything to the contrary contained in this Agreement, the Founders, Heffernan
and the Trustee jointly and severally, without limit as to amount or duration,
agree to indemnify defend and hold harmless PHMX, Acquisition and the Company
from and in respect of any and all Adverse Consequences that such Indemnified
PHMX Party or the Company may suffer through and after the date of the claim for
indemnification arising out of or due to any claim whatsoever by Dr. Joseph
Mendels or CNS or the breach by Dr. Mendels or CNS of any agreement executed in
connection with the Merger or this Agreement. This Section 12.1(b) shall survive
the Closing of the Merger indefinitely and shall not be limited in amount and no
threshold level with respect to any Adverse Consequences need be attained before
a claim by PHMX or the Company be made for indemnification under this Section
12.1(b).

                                  ARTICLE XIII
                                   TERMINATION

                 13.1 Termination. This Agreement may be terminated and the
Merger may be abandoned at any time prior to the Closing:

                 (a) By mutual written consent duly authorized by the Board of
         Directors of Acquisition and the Company;

                 (b) By Acquisition or the Company if the Average Closing Price
         Per Share is less than or equal to Twelve Dollars ($12.00);

                 (c) By Acquisition or the Company if

                     (i)  any Governmental Authority of competent jurisdiction
                          shall have issued an order, decree or ruling, or taken
                          any other action, permanently restraining, enjoining
                          or otherwise prohibiting the transactions contemplated
                          by this Agreement, provided that no termination shall
                          be permitted under this paragraph unless the party
                          seeking such termination shall have used its
                          reasonable best efforts to oppose such issuance or
                          taking; or

                     (ii) the other party commits any material breach of its
                          representations, warranties or covenants set forth
                          herein and such breach has not been cured within seven
                          (7) days after notice is given to terminate this
                          Agreement as a result of such breach;


                                      -41-
<PAGE>

                 (d) By Acquisition or the Company, on or after October 15,
         1997 (the "Termination Date"); provided, however, that, notwithstanding
         the previous waiver by Nasdaq of its shareholder approval requirement,
         if Nasdaq subsequently requires PHMX to seek the approval of its
         shareholders of this Agreement and the transactions contemplated
         hereby, that the Termination Date shall be extended to such date not
         later than January 31, 1998, provided that (i) PHMX files its Proxy
         Statement with the SEC twenty-one (21) days following the Termination
         Date, (ii) PHMX mails to its stockholders the Proxy Statement one (1)
         week after it receives written approval by the SEC of its Proxy
         Statement and other Proxy Materials (the "Mailing Date"), and (iii)
         PHMX holds the meeting of its shareholders to approve the Merger no
         later than thirty (30) days following the Mailing Date. If PHMX fails
         to meet the requirements of clause (i), (ii) or (iii) of the
         immediately preceding sentence, the Company, may, at its option,
         terminate the Agreement.

                 Upon the occurrence of any of the events specified in this
Section 13.1 (other than paragraph (a) hereof), written notice of such event
shall forthwith be given to the other parties to this Agreement, whereupon this
Agreement shall terminate and the Merger shall be abandoned.

                 13.2 Effect of Termination. In the event of the termination of
this Agreement and abandonment of the Merger pursuant to Section 13.1:

                 (a) This Agreement, except for the provisions of Section 7.6
         and Articles XI, XII, XIII and XIV, shall forthwith become void and be
         of no effect, without any liability on the part of any party or its
         affiliates, directors, officers or shareholders; provided that nothing
         in this Section 13.2(a) shall relieve any party to this Agreement of
         liability for breach of this Agreement; and

                 (b) In the event that the Agreement is terminated as a result
         of (i) the failure of the shareholders of the Company to approve the
         Merger, and the Company sells all or a part of the assets or stock of
         the Business to a third party or merges with a third party within
         twelve (12) months after such termination, (ii) the refusal of the
         Company to consummate the Merger for any reason other than the failure
         of a condition to Closing set forth in Article IX (except a failure
         resulting from the actions specified in clause (i)) or the action of
         the Company pursuant to Section 13.1(e), or (iii) the action of the
         Company pursuant to Section 13.1(e), PHMX at its option may elect (X)
         to seek specific performance of this Agreement or any other equitable
         remedies available to it, provided


                                      -42-
<PAGE>

         that the Agreement is terminated for the reason set forth in clause
         (ii) above, or (Y) to have the Company pay, and in such event the
         Company shall pay on demand, to PHMX Three Million Dollars ($3,000,000)
         as full and complete liquidated damages, it being specifically
         understood and agreed that in the event of such a termination the
         damages suffered by PHMX will be difficult to ascertain.

                 (c) In the event that the Agreement is terminated by PHMX or
         Acquisition for a reason other than a failure of a condition to Closing
         set forth in Articles VIII or X, and PHMX and/or Acquisition or any
         affiliate thereof within twelve (12) months acquires a controlling
         interest in any third party site management or clinical research
         organization or other company performing functions substantially
         similar to the Business of the Company, or a hybrid of such types of
         companies, PHMX shall pay on demand to the Company Three Million
         Dollars ($3,000,000) as full and complete liquidated damages, it being
         specifically understood and agreed that in the event of such a
         termination the damages suffered by the Company will be difficult to
         ascertain.


                                   ARTICLE XIV
                                  MISCELLANEOUS

                 14.1 Certain Definitions. As used in this Agreement, the
following terms shall have the respective meanings set forth below:

         "Adverse Consequences" means all actions, suits, proceedings, hearings,
investigations, charges, complaints, claims, demands, injunctions, judgments,
orders, decrees, rulings, damages, dues, penalties, fines, costs, amounts paid
in settlement, Liabilities, obligations, Taxes, liens, losses, expenses, and
fees, including court costs and reasonable attorneys' fees and expenses, and
including costs of environmental investigations and/or cleanups ordered by
federal, state, local, or foreign governments (or any agencies thereof), all as
offset by any net tax benefit to the party so affected.

         "Affiliate" has the meaning set forth in Rule 12b-2 of the regulations
promulgated under the Securities Exchange Act.

         "Alternative Transaction" has the meaning provided in Section 5.1.

         "Average Closing Price Per Share" or "ACPPS" has the meaning provided
in Section 1.5.

         "Balance Sheet Date" has the meaning provided in Section 3.8.

         "Balance Sheet" has the meaning provided in Section 3.6.


                                      -43-
<PAGE>
RIDER A
         "Certificate" has the meaning provided in Section 1.6.

         "Claim" means liability, claim, assessment, security interest, lien,
restriction, encumbrance, or right, title or interest in others.

         "Clinical Trials" means the administration and testing of certain
pharmaceutical and other forms of therapies on human subjects in order to
determine the efficacy of such treatments, and any other activities incidental
thereto.

         "Closing" has the meaning provided in Section 2.1.

         "Closing Date" means the date on which the Closing occurs.

         "Code" means the Internal Revenue Code of 1986, as amended to date.

         "Company Financial Statements" has the meaning provided in Section 3.6.

         "Company Proprietary Asset" has the meaning provided in Section 3.13.

         "Company Shareholders" has the meaning provided in Section 1.6.

         "Confidential Information" has the meaning provided in Section 7.6.

         "Contracts" has the meaning provided in Section 3.14.

         "Conversion Rate" means the number of shares of PHMX Common Stock
composing the Merger Consideration divided by 900,039.51.

         "CNS" had the meaning provided in Section 8.15.

         "Deductible Expenses" shall be equal to (I) any and all fees and
expenses of Joseph Anton, Incorporated, James P. Redding & Associates, Deloitte
& Touche LLP, Hutchins, Wheeler & Dittmar, P.C., and Sansiveri, Kimball &
McNamee, L.L.P., in connection with the preparation and negotiation of, and
services performed in connection with, the Letter of Intent dated March 12, 1997
between the Company and PHMX, this Agreement and the Merger, as of the last
business day prior to the Closing, plus a good faith estimate of such expenses
to be incurred in connection with the Closing, plus (II) the Mendels' Expense
plus (III) $250,000.

         "Disclosure Schedule" means the schedules referenced in Articles III
and IV of this Agreement and that are attached hereto.


                                      -44-
<PAGE>

         "Encumbrance" means any charge, claim, community property interest,
condition, equitable interest, lien, option, pledge, security interest, right of
first refusal, or restriction of any kind, including, without limitation, any
restriction on use, voting, transfer, receipt of income, or exercise of any
other attribute of ownership.

         "ERISA" has the meaning provided in Section 3.19.

         "Environmental Laws" means, collectively, the Clean Air Act, the Clean
Water Act, the Resource Conservation and Recovery Act of 1976, the Hazardous
Materials Transportation Act, the Comprehensive Environmental Response,
Compensation and Liability Act of 1980, the Emergency Planning and Community
Right-to-Know Act or any other federal, state or local environmental law.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended,
including the rules and regulations promulgated thereunder.

         "GAAP" means generally accepted accounting principles.

         "Governmental Authority" means any federal, state or municipal court
and any other governmental or public department, commission, board, bureau,
agency, authority or instrumentality, domestic or foreign.

         "Hazardous Substance" means any chemical, pollutant, contaminant, waste
(including, without limitation, toxic, hazardous, infectious, sanitary, solid,
radioactive and petroleum waste collectively, "Waste"), toxic substance,
hazardous substance, extremely hazardous substance, hazardous material,
radioactive material, oil and petroleum product, as such terms, or any similar
terms, are or shall be used under any applicable laws relating to pollution or
protection of the environment, natural resources or human health.

         "IRS" means the Internal Revenue Service.

         "Knowledge" means the actual knowledge of one or more of Dr. Michael
Rothman, Dr. Walter Brown, Michael Heffernan, Donald Palazini or any person not
named above who constitutes an "Executive Officer" of the Company for purposes
of the Securities Act.

         "Law" means all federal, state, local and foreign laws, regulations,
rules, ordinances, permits (including, without limitation, authorizations,
approvals, registrations and licenses), administrative and other orders,
judicial decisions or the like.

         "Leased Premises" has the meaning provided in Section 3.11.

         "Leases" has the meaning provided in Section 3.11.

                                      -45-
<PAGE>

         "Liability" means any liability (whether known or unknown, whether
asserted or unasserted, whether absolute or contingent, whether accrued or
unaccrued, whether liquidated or unliquidated, and whether due or to become
due), including any liability for Taxes.

         "Material Adverse Change" has the meaning provided in Section 3.9.

         "Mendels" has the meaning provided in Section 8.15.

         "Mendels' Expense" means the amount, valued using the ACPPS, of any
settlement agreement between the parties to this Agreement, Mendels and CNS.

         "Nasdaq" means The Nasdaq National Market.

         "Ordinary Course of Business" means the ordinary course of business
consistent with past custom and practice (including with respect to quantity and
frequency).

         "Permits" has the meaning provided in Section 3.12.

         "Person" means an individual, a partnership, a corporation, a firm, an
association, a joint stock company, a trust, a joint venture, an unincorporated
organization, or a governmental entity (or any department, agency, or political
subdivision thereof), or any other legally recognized entity.

         "Plan" has the meaning provided in Section 3.19.

         "Pooling Approval" has the meaning provided in Section 8.8.

         "Proprietary Asset" means any (a) patent, patent application, trademark
(whether registered or unregistered), trademark application, trade name,
fictitious business name, service mark (whether registered or unregistered),
service mark application, copyright (whether registered or unregistered),
copyright application, mask work, mask work application, trade secret, know-how,
confidential information, customer list, franchise, system, computer software,
computer program, invention, design, blueprint, engineering drawing, proprietary
product, technology, proprietary right or other intellectual property right or
intangible asset; or (b) license or right to use or exploit any of the
foregoing.

         "Proxy Statement" has the meaning provided in Section 4.5.

         "Registration Agreement" has the meaning provided in Section 10.5

         "SEC" means the Securities and Exchange Commission.


                                      -46-
<PAGE>

         "Securities Act" means the Securities Act of 1933, as amended, and the
rules and regulations promulgated thereunder.

         "Shareholder Agreement" has the meaning provided in Section 10.4.

         "Stub Period Subchapter S Tax Liability" has the meaning provided in
Section 8.16.

         "Tax" means any federal, state, local, or foreign income, gross
receipts, license, payroll, employment, excise, severance, stamp, occupation,
premium, windfall profits, environmental (including taxes under Code Sec. 59A),
customs duties, capital stock, franchise, profits, withholding, social security
(or similar), unemployment, disability, real property, personal property, sales,
use, transfer, registration, value added, alternative or add-on minimum,
estimated, or other tax of any kind whatsoever, including any interest, penalty,
or addition thereto, whether disputed or not.

         "Trusts" means The Alexander Rothman 1993 Qualified Sub-Chapter S Trust
and The Julie Rothman 1993 Qualified Sub-Chapter S Trust.

         14.2 Notices. All notices, requests, consents and other communications
hereunder shall be in writing, shall be addressed to the receiving party's
address set forth below or to such other address as a party may designate by
notice hereunder, and shall be either (i) delivered by hand, (ii) made by telex,
telecopy or facsimile transmission with a confirmatory copy by regular mail,
(iii) sent by recognized overnight courier or (iv) sent by registered or
certified mail, return receipt requested, postage prepaid.

         If to Acquisition or PHMX:

         PhyMatrix Corp.
         777 South Flagler Drive, Suite 1000E
         West Palm Beach, FL  33401
         Attn:  Alberto Hernandez, Esq.
         Facsimile telephone number:  (561) 833-7175

         with a copy to:

         Michael J. Bohnen, Esq.
         Nutter, McClennen & Fish, LLP
         One International Place
         Boston, MA 02110-2699
         Facsimile telephone number: (617) 973-9748

         If to the Company or Mr. Heffernan:


                                      -47-
<PAGE>

         Clinical Studies, Ltd.
         2 Charles Street
         Providence, RI  02904
         Attn:  Michael T. Heffernan
         Facsimile telephone number: (401) 831-6758

         With a copy to:

         Frederick H. Grein, Jr., Esq.
         Andrew J. Hayden, Esq.
         Hutchins, Wheeler & Dittmar, PC
         101 Federal Street
         Boston, MA 02110
         Facsimile telephone number: (617) 951-1295

         James P. Redding, Esq.
         Redding & Associates
         170 Westminster Street
         Providence, RI  02903
         Facsimile telephone number: (401) 751-0031

         If to Dr. Brown:

         101 Driftwood Drive
         Tiverton, RI  02878

         If to Dr. Rothman or the Trustee:

         37 Grayson Lane
         Newton Lower Falls, MA  02162
         Facsimile telephone number: (617) 332-5914

All notices, requests, consents and other communications hereunder shall be
deemed to have been properly given (i) if by hand, at the time of the delivery
thereof to the receiving party at the address of such party set forth above,
(ii) if made by telex, telecopy or facsimile transmission, at the time that
receipt thereof has been acknowledged by electronic confirmation or otherwise,
(iii) if sent by overnight courier, on the next business day following the day
such notice is delivered to the courier service or (iv) if sent by registered or
certified mail, on the fifth business day following the day such mailing is
made.

                 14.3 Entire Agreement. This Agreement together with the
Exhibits and Schedules hereto and the other documents executed and to be
executed in connection herewith


                                      -48-
<PAGE>

(together, the "Documents") embodies the entire agreement and understanding
between the parties hereto with respect to the subject matter hereof and
supersedes all prior oral or written agreements and understandings relating to
the subject matter hereof. No statement, representation, warranty, covenant or
agreement of any kind not expressly set forth in the Documents shall affect, or
be used to interpret, change or restrict, the express terms and provisions of
this Agreement.

                 14.4 Modifications and Amendments. The terms and provisions of
this Agreement may be modified or amended only by written agreement executed by
all parties hereto.

                 14.5 Waivers and Consents. No failure or delay by a party
hereto in exercising any right, power or remedy under this Agreement, and no
course of dealing between the parties hereto, shall operate as a waiver of any
such right, power or remedy of the party. No single or partial exercise of any
right, power or remedy under this Agreement by a party hereto, nor any
abandonment or discontinuance of steps to enforce any such right, power or
remedy, shall preclude such party from any other or further exercise thereof or
the exercise of any other right, power or remedy hereunder. The election of any
remedy by a party hereto shall not constitute a waiver of the right of such
party to pursue other available remedies. No notice to or demand on a party not
expressly required under this Agreement shall entitle the party receiving such
notice or demand to any other or further notice or demand in similar or other
circumstances or constitute a waiver of the rights of the party giving such
notice or demand to any other or further action in any circumstances without
such notice or demand. The terms and provisions of this Agreement may be waived,
or consent for the departure therefrom granted, only by written document
executed by the party entitled to the benefits of such terms or provisions. No
such waiver or consent shall be deemed to be or shall constitute a waiver or
consent with respect to any other terms or provisions of this Agreement, whether
or not similar. Each such waiver or consent shall be effective only in the
specific instance and for the purpose for which it was given, and shall not
constitute a continuing waiver or consent.

                 14.6 Assignment. Neither this Agreement, nor any right
hereunder, may be assigned by any of the parties hereto without the prior
written consent of the other parties; provided, however, Acquisition may assign
this Agreement to any of its affiliates which it controls, is controlled by or
is under common control with.

                 14.7 Parties in Interest. This Agreement shall be binding upon
and inure solely to the benefit of each party hereto and their permitted
assigns, and nothing in this Agreement, express or implied, is intended to
confer upon any other person any rights or remedies of any nature whatsoever
under or by reason of this Agreement. Nothing in this Agreement shall be
construed to create any rights or obligations except among the parties hereto,
and no person or entity shall be regarded as a third-party beneficiary of this
Agreement.


                                      -49-
<PAGE>

                 14.8 Governing Law. This Agreement and the rights and
obligations of the parties hereunder shall be construed in accordance with and
governed by the internal laws of the State of Delaware, without giving effect to
the conflict of law principles thereof.

                 14.9 Jurisdiction and Service of Process. Any legal action or
proceeding with respect to this Agreement may be brought in the courts of the
Commonwealth of Massachusetts or the State of Delaware, or of the United States
of America for the District of Massachusetts or the District of Delaware. By
execution and delivery of this Agreement, each of the parties hereto accepts for
itself and in respect of its property, generally and unconditionally, the
jurisdiction of the aforesaid courts. The parties hereby irrevocably waive any
objection or defense that they may now or hereafter have to the assertion of
personal jurisdiction by any such court in any such action or to the laying of
the venue of any such action in any such court, and hereby waive, to the extent
not prohibited by law, and agree not to assert, by way of motion, as a defense,
or otherwise, in any such proceeding, any claim that it is not subject to the
jurisdiction of the above-named courts for such proceedings. Each of the parties
hereto irrevocably consents to the service of process of any of the
aforementioned courts in any such action or proceeding by the mailing of copies
thereof by registered mail, postage prepaid, to the party at its address set
forth in Section 13.2 hereof and irrevocably waives any objection or defense
that it may now or hereafter have to the sufficiency of any such service of
process in any such action. Nothing in this Section 13.9 shall affect the rights
of the parties to commence any such action in any other forum or to serve
process in any such action in any other manner permitted by law.

                 14.10 Severability. In the event that any court of competent
jurisdiction shall finally determine that any provision, or any portion thereof,
contained in this Agreement shall be void or unenforceable in any respect, then
such provision shall be deemed limited to the extent that such court determines
it enforceable, and as so limited shall remain in full force and effect. In the
event that such court shall determine any such provision, or portion thereof
wholly unenforceable, the remaining provisions of this Agreement shall
nevertheless remain in full force and effect.

                 14.11 Interpretation. The parties hereto acknowledge and agree
that: (i) each party and its counsel reviewed and negotiated the terms and
provisions of this Agreement and have contributed to its revision; (ii) the rule
of construction to the effect that any ambiguities are resolved against the
drafting party shall not be employed in the interpretation of this Agreement;
and (iii) the terms and provisions of this Agreement shall be construed fairly
as to all parties hereto and not in favor of or against any party, regardless of
which party was generally responsible for the preparation of this Agreement.

                 14.12 Headings and Captions. The headings and captions of the
various subdivisions of this Agreement are for convenience of reference only and
shall in no way


                                      -50-
<PAGE>

modify, or affect, or be considered in construing or interpreting the meaning or
construction of any of the terms or provisions hereof.

                 14.13 Choice of Remedies and Enforcement. The parties shall be
entitled to pursue any and all remedies available to them, in law or in equity,
in the event of a breach of this Agreement. Each of the parties hereto
acknowledges and agrees that the rights acquired by each party hereunder are
unique and that irreparable damage would occur in the event that any of the
provisions of this Agreement to be performed by the other party were not
performed in accordance with their specific terms or were otherwise breached.
Accordingly, in addition to any other remedy to which the parties hereto are
entitled at law or in equity, each party hereto shall be entitled to an
injunction or injunctions to prevent breaches of this Agreement by the other
party and to enforce specifically the terms and provisions hereof in any federal
or state court to which the parties have agreed hereunder to submit to
jurisdiction.

                 14.14 Expenses. Except as provided elsewhere herein, each of
the parties hereto shall pay its own fees and expenses (including the fees of
any attorneys, accountants, appraisers or others engaged by such party) in
connection with this Agreement and the transactions contemplated hereby whether
or not the transactions contemplated hereby are consummated.

                 14.15 Counterparts. This Agreement may be executed in one or
more counterparts, and by different parties hereto on separate counterparts,
each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

                  [Remainder of page intentionally left blank]


                                      -51-
<PAGE>

         IN WITNESS WHEREOF, Acquisition, PHMX and the Company have executed
this Agreement as of the day and year first above written.

Attest:                                   CLINICAL STUDIES LTD.


   /s/ Walter Brown                       By: /s/ Michael T. Heffernan
- ---------------------------------             ---------------------------------
   Walter Brown, Secretary                Title:  Chief Executive Officer


Attest:                                   PHYMATRIX ACQUISITION I, INC.


   /s/ Albert Hernandez                   By: /s/ Robert A. Miller
- ---------------------------------             ---------------------------------
   Albert Hernandez, Secretary            Title:  President


Attest:                                   PHYMATRIX CORP.


   /s/ Albert Hernandez                   By: /s/ Robert A. Miller
- ---------------------------------             ---------------------------------
   Albert Hernandez, Secretary            Title:  President

Witness:

   /s/                                        /s/ Michael Rothman
- ---------------------------------             ---------------------------------
                                              Michael Rothman

Witness:

   /s/                                        /s/ Walter Brown
- ---------------------------------             ---------------------------------
                                              Walter Brown

Witness:

    /s/                                       /s/ Michael T. Heffernan
- ---------------------------------             ---------------------------------
                                              Michael T. Heffernan


                                      -52-
<PAGE>

SIGNATURE PAGE CON'T:


Witness:

    /s/                                       /s/ Ronald Philips, as Trustee
- ---------------------------------             ---------------------------------
                                              Ronald Phillips, as Trustee of
                                              The Alexander Rothman 1993
                                              Qualified Sub-Chapter S Trust
Witness:

    /s/                                       /s/ Ronald Philips, as Trustee
- ---------------------------------             ---------------------------------
                                              Ronald Phillips, as Trustee of
                                              The Julie Rothman 1993
                                              Qualified Sub-Chapter S Trust

                                      -53-



                         INDEPENDENT AUDITORS' CONSENT

We consent to the incorporation by reference in Registration Statements No.
333-03853 on Form S-8, No. 333-31973 on Form S-3, No. 333-08269 on Form S-3 and
No. 333-09187 on Form S-4 of PhyMatrix Corp. of our report dated May 28, 1997
(relating to the combined financial statements of Clinical Studies Ltd. and
Clinical Marketing Ltd.) appearing in this Form 8-K Current Report of PhyMatrix
Corp.


DELOITTE & TOUCHE LLP
Boston, Massachusetts
October 1, 1997




                         INDEPENDENT AUDITORS' CONSENT

We consent to the incorporation by reference in Registration Statements No.
333-03853 on Form S-8, No. 333-31973 on Form S-3, No. 333-08269 on Form S-3 and
No. 333-09187 on Form S-4 of PhyMatrix Corp. of our report dated April 14, 1997
(except for Note 7, which is dated April 23, 1997) (relating to the financial
statements of Clinical Studies Ltd.) appearing in this Form 8-K Current Report
of PhyMatrix Corp.

SANSIVERI, KIMBALL & McNAMEE, L.L.P.
Providence, Rhode Island
October 2, 1997


<TABLE> <S> <C>

<ARTICLE> 5
<CURRENCY> U.S. DOLLARS
       
<S>                             <C>                     <C>                     <C>                     <C>
<PERIOD-TYPE>                   6-MOS                   12-MOS                   12-MOS                   12-MOS
<FISCAL-YEAR-END>                          JAN-31-1998             DEC-31-1996             DEC-31-1995             DEC-31-1994
<PERIOD-START>                             FEB-01-1997             JAN-01-1996             JAN-01-1995             JAN-01-1994
<PERIOD-END>                               JUL-31-1997             DEC-31-1996             DEC-31-1995             DEC-31-1994
<EXCHANGE-RATE>                                      1                       1                       1                       1
<CASH>                                         744,772               1,428,276               3,595,454                 107,402
<SECURITIES>                                         0                       0                       0                       0
<RECEIVABLES>                                7,631,640               6,175,469               2,446,028                 214,175
<ALLOWANCES>                                         0               (278,000)               (236,000)                       0
<INVENTORY>                                          0                       0                       0                       0
<CURRENT-ASSETS>                             8,376,412               7,325,745               5,805,482                 321,577
<PP&E>                                       1,025,476                 763,788                 553,432                 119,791
<DEPRECIATION>                               (394,159)               (302,019)               (178,669)                (42,542)
<TOTAL-ASSETS>                              16,916,935              15,186,358               6,280,194                 568,694
<CURRENT-LIABILITIES>                        2,772,395               2,980,248               3,416,847                 393,493
<BONDS>                                              0                       0                       0                       0
                                0                       0                       0                       0
                                          0                       0                       0                       0
<COMMON>                                       627,940                 627,940                     300                     100
<OTHER-SE>                                   4,497,409               4,260,430               2,758,563                  47,388
<TOTAL-LIABILITY-AND-EQUITY>                16,916,935              15,186,358               6,280,194                 568,694
<SALES>                                     13,128,176              18,040,124              13,351,843               4,921,285
<TOTAL-REVENUES>                            13,128,176              18,040,124              13,351,843               4,921,285
<CGS>                                                0                       0                       0                       0
<TOTAL-COSTS>                                        0                       0                       0                       0
<OTHER-EXPENSES>                            12,207,334              14,738,292              10,444,639               5,019,282
<LOSS-PROVISION>                                     0                       0                       0                       0
<INTEREST-EXPENSE>                             291,363                  68,373                (23,971)                     705
<INCOME-PRETAX>                                629,479               3,233,459               2,931,175                (98,702)
<INCOME-TAX>                                         0                       0                       0                       0
<INCOME-CONTINUING>                            629,479               3,233,459               2,931,175                (98,702)
<DISCONTINUED>                                       0                       0                       0                       0
<EXTRAORDINARY>                                      0                       0                       0                       0
<CHANGES>                                            0                       0                       0                       0
<NET-INCOME>                                   629,479               3,233,459               2,931,175                (98,702)
<EPS-PRIMARY>                                        0                       0                       0                       0
<EPS-DILUTED>                                        0                       0                       0                       0
        

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