COMBICHEM INC
DEF 14A, 1999-04-06
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1
 
                            SCHEDULE 14A INFORMATION
                                (Rule 14a-101)
 
                  PROXY STATEMENT PURSUANT TO SECTION 14(A) OF
             THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )
 
Filed by the Registrant [X]
 
Filed by a Party other than the Registrant [ ]
 
Check the appropriate box:
 
[ ]  Preliminary Proxy Statement                
[ ]  Confidential, for Use of the Commission Only
     (as permitted by Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to sec.240.14a-11(c) or sec.240.14a-12
 
                                CombiChem, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
[X]  No fee required.
 
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
 
     (1)  Title of each class of securities to which transaction applies:
 
     (2)  Aggregate number of securities to which transaction applies:
 
     (3)  Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined):
 
     (4)  Proposed maximum aggregate value of transaction:
 
     (5)  Total fee paid:
 
[ ]  Fee paid previously with preliminary materials.
 
[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
 
     (1)  Amount Previously Paid:
 
     (2)  Form, Schedule or Registration Statement No.:
 
     (3)  Filing Party:
 
     (4)  Date Filed:
<PAGE>   2
 
                                COMBICHEM, INC.
                              9050 CAMINO SANTA FE
                          SAN DIEGO, CALIFORNIA 92121
 
                                 April 6, 1999
 
Dear fellow stockholder:
 
     You are cordially invited to attend the Annual Meeting of Stockholders of
CombiChem, Inc., which will be held in the Delphi Room at the Hyatt Regency La
Jolla Aventine, 3777 La Jolla Village Drive, San Diego, California on May 6,
1999 at 10:00 a.m.
 
     Details of the business to be conducted at the Annual Meeting are given in
the attached Notice of Annual Meeting of Stockholders and Proxy Statement which
you are urged to read carefully.
 
     Whether or not you plan to attend the Annual Meeting, please sign, date and
return the enclosed proxy promptly in the accompanying reply envelope. If you
decide to attend the Annual Meeting and wish to change your proxy vote, you may
do so automatically by voting in person at the Annual Meeting.
 
     We look forward to seeing you on May 6, 1999.
 
                                           Sincerely,
                                           /s/ VICENTE ANIDO, JR.
 
                                           Vicente Anido, Jr.
                                           President, Chief Executive Officer
                                           and Director
 
                             YOUR VOTE IS IMPORTANT
 
     In order to assure your representation at the meeting, you are requested to
complete, sign and date the enclosed proxy as promptly as possible and return it
in the enclosed envelope. No postage need be affixed if mailed in the United
States.
<PAGE>   3
 
                                COMBICHEM, INC.
                              9050 CAMINO SANTA FE
                          SAN DIEGO, CALIFORNIA 92121
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
 
                             TO BE HELD MAY 6, 1999
 
     The Annual Meeting of Stockholders of CombiChem, Inc. ("CombiChem" or the
"Company") will be held in the Delphi Room at the Hyatt Regency La Jolla
Aventine, 3777 La Jolla Village Drive, San Diego, California on Thursday, May 6,
1999 at 10:00 a.m. for the following purposes:
 
     1. To elect two directors to hold office for a term of three years or until
        their respective successors are elected and qualified.
 
     2. To approve an amendment to the Company's 1997 Stock Incentive Plan to
        increase the authorized number of shares of Common Stock available for
        issuance under the Plan by 1,000,000 shares.
 
     3. To ratify the appointment of Ernst & Young LLP as the Company's
        independent auditors for the fiscal year ending December 31, 1999.
 
     4. To transact such other business which may properly come before the
        Annual Meeting or any adjournment(s) thereof.
 
     The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice. All stockholders of record at the close of
business on March 31, 1999 will be entitled to vote at the Annual Meeting and at
any adjournment thereof. The transfer books will not be closed. A list of
stockholders entitled to vote at the Annual Meeting will be available for
inspection at the offices of the Company.
 
                                          By Order of the Board of Directors
                                          /s/ FAYE H. RUSSELL
 
Dated: April 6, 1999                      Faye H. Russell
                                          Secretary
 
     ABSTENTIONS AND BROKER NONVOTES WILL BE COUNTED FOR PURPOSES OF DETERMINING
WHETHER A QUORUM IS PRESENT AT THE ANNUAL MEETING. ABSTENTIONS WILL HAVE THE
EFFECT OF NEGATIVE VOTES. WHETHER OR NOT YOU PLAN TO ATTEND THE ANNUAL MEETING,
PLEASE COMPLETE, SIGN AND DATE THE ACCOMPANYING PROXY AND RETURN IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE, WHICH REQUIRES NO POSTAGE IF MAILED IN THE UNITED
STATES. YOU MAY REVOKE YOUR PROXY IN THE MANNER DESCRIBED IN THE ACCOMPANYING
PROXY STATEMENT. IF YOU ATTEND THE MEETING, YOU MAY VOTE IN PERSON, IF YOU WISH
TO DO SO, EVEN IF YOU HAVE PREVIOUSLY SENT IN YOUR PROXY.
<PAGE>   4
 
                                COMBICHEM, INC.
                              9050 CAMINO SANTA FE
                          SAN DIEGO, CALIFORNIA 92121
 
                                PROXY STATEMENT
 
                         ANNUAL MEETING OF STOCKHOLDERS
 
                             TO BE HELD MAY 6, 1999
 
     The enclosed proxy is solicited on behalf of the Board of Directors of
CombiChem, Inc., a Delaware corporation ("CombiChem" or the "Company"), for use
at the annual meeting of stockholders to be held on May 6, 1999, and at any
adjournment or postponement of the annual meeting (the "Annual Meeting"). The
Annual Meeting will be held at 10:00 a.m. in the Delphi Room at the Hyatt
Regency La Jolla Aventine, 3777 La Jolla Village Drive, San Diego, California.
All stockholders of record on March 31, 1999 will be entitled to notice of and
to vote at the Annual Meeting. This Proxy Statement and accompanying proxy (the
"Proxy") were first mailed to stockholders on or about April 6, 1999.
 
     The mailing address of the principal executive office of the Company is
9050 Camino Santa Fe, San Diego, California 92121.
 
                               PURPOSE OF MEETING
 
     The specific proposals to be considered and acted upon at the Annual
Meeting are summarized in the accompanying Notice of Annual Meeting of
Stockholders (collectively, the "Proposals"). Each Proposal is described in more
detail in this Proxy Statement.
 
                         VOTING RIGHTS AND SOLICITATION
 
VOTING
 
     On March 31, 1999, there were 13,450,421 shares of Common Stock
outstanding. Each holder of Common Stock is entitled to one vote on all matters
brought before the Annual Meeting. Stockholders may not cumulate votes in the
election of directors.
 
     Abstentions and broker non-votes will be counted for purposes of
determining whether a quorum is present at the Annual Meeting. Abstentions will
have the effect of negative votes and broker non-votes will not be counted in
determining whether any Proposal has been approved.
 
REVOCABILITY OF PROXIES
 
     Any person giving a proxy has the power to revoke it at any time before its
exercise. It may be revoked by filing with the Secretary of the Company at the
Company's principal executive office, 9050 Camino Santa Fe, San Diego,
California 92121, a notice of revocation or another signed proxy with a later
date. You may also revoke your proxy by attending the Annual Meeting and voting
in person.
 
SOLICITATION
 
     The Company will bear the entire cost of solicitation, including the
preparation, assembly, printing and mailing of this Proxy Statement, the proxy
and any additional soliciting materials furnished to stockholders. Copies of
solicitation materials will be furnished to brokerage houses, fiduciaries and
custodians holding shares in their names that are beneficially owned by others
so that they may forward the solicitation materials to such beneficial owners.
In addition, the Company may reimburse such persons for their costs of
forwarding the solicitation materials to such beneficial owners. The original
solicitation of proxies by mail may be supplemented by solicitation by
telephone, telegram or other means by directors, officers, employees or agents
 
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of the Company. No additional compensation will be paid to these individuals for
any such services. Except as described above, the Company does not presently
intend to solicit proxies other than by mail.
 
                                   PROPOSAL 1
 
                             ELECTION OF DIRECTORS
 
     The Board of Directors of the Company is currently composed of seven
members. The Board of Directors is classified into three classes of directors
serving staggered three-year terms, with one class of directors to be elected at
each annual meeting of stockholders. At the meeting, two directors will be
elected to hold office for three years or until their successors are elected and
qualified. Peter L. Myers, Ph.D. and Michael J. Pazzani, Ph.D., who are
presently serving as directors, have been nominated for re-election by the Board
of Directors. Unless the enclosed proxy withholds authority to vote for one or
more of the nominees or is a broker non-vote, the shares represented by such
proxy will be voted for the election of the directors as the Board's nominee. If
either nominee is unable to serve, which is not expected, the shares represented
by the enclosed proxy will be voted for such other candidate as may be nominated
by the Board of Directors.
 
VOTE REQUIRED
 
     The two candidates receiving the highest number of affirmative votes of the
stockholders entitled to vote at the Annual Meeting will be elected directors of
CombiChem. Unless otherwise instructed, the proxyholders will vote each returned
proxy for the nominees named below, for election to the class indicated below,
or for as many nominees of the Board of Directors as possible, such votes to be
distributed among such nominees in the manner as the proxyholders see fit.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
     The Board of Directors unanimously recommends a vote FOR Dr. Myers and Dr.
Pazzani.
 
NOMINEES FOR ELECTION TO TERMS WHICH EXPIRE AT THE ANNUAL MEETING OF
STOCKHOLDERS IN 2002
 
     PETER L. MYERS, PH.D., 55. Dr. Myers has served as a Director, Vice
President and Chief Scientific Officer of the Company since joining the Company
in March 1995. Dr. Myers has also served as Chief Operating Officer of the
Company since September 1995 and served as the acting Chief Executive Officer
from September 1995 to March 1996. Prior to joining the Company, Dr. Myers
served as Vice President, Drug Discovery and Development at Onyx Pharmaceuticals
Inc. from November 1993 through March 1995, where he was responsible for all
aspects of drug discovery and development leading to potential novel classes of
anti-cancer drugs. Prior to that, Dr. Myers served as Vice President, Chemistry
Research of Glaxo Inc. Research Institute from January 1991 through December
1993. Dr. Myers holds a B.S. in Chemistry and a Ph.D. in Organic Chemistry from
Leeds University.
 
     MICHAEL J. PAZZANI, PH.D., 40. Dr. Pazzani has served as a Director of the
Company since March 1999. Dr. Pazzani is Chair of the Department of Information
and Computer Science and a Professor of Information & Computer Science and
Cognitive Science at the University of California, Irvine. He has been
affiliated with the University of California, Irvine, since 1988. Dr. Pazzani
holds B.S. and M.S. degrees in Computer Engineering from the University of
Connecticut and a Ph.D. in Computer Science from the University of California,
Los Angeles.
 
DIRECTORS WHOSE TERMS EXPIRE AT THE ANNUAL MEETING OF STOCKHOLDERS IN 2000
 
     PHILIPPE O. CHAMBON, M.D., PH.D., 40. Dr. Chambon has served as a Director
of the Company since August 1995. Dr. Chambon is a General Partner of the Sprout
Group. He joined Sprout in May 1995. From May 1993 to April 1995, Dr. Chambon
served as Manager in the Healthcare Practice of The Boston Consulting Group, a
leading management consulting firm. Previously, Dr. Chambon was an executive
with Sandoz Pharmaceuticals Corporation, a leading pharmaceutical company, from
September 1987 to April 1993. In his last capacity there, he was the Executive
Director of New Product Management. He is currently a
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director of Transcend Therapeutics and of several private companies. Dr. Chambon
received an M.D. (with honors) and Ph.D. from the University of Paris and an
M.B.A. from Columbia University. Dr. Chambon currently serves as a member of the
Company's Audit Committee.
 
     WILLIAM SCOTT, PH.D., 58. Dr. Scott has served as a Director of the Company
since January 1997. Since March 1997, Dr. Scott has served as the Chief
Executive Officer of Physiome Sciences, Inc. From 1983 until December 1996, Dr.
Scott served in various executive positions with Bristol-Myers Squibb
Pharmaceutical Research Institute and as its Senior Vice President, Drug
Discovery Research since 1991. Dr. Scott received a B.S. in Chemistry from the
University of Illinois and a Ph.D. in Biochemistry from the California Institute
of Technology and was an NIH Postdoctoral Fellow at The Rockefeller University.
Dr. Scott serves on the Board of Directors of a private company. Dr. Scott
currently serves as a member of the Company's Compensation Committee.
 
DIRECTORS WHOSE TERMS EXPIRE AT THE ANNUAL MEETING OF STOCKHOLDERS IN 2001
 
     VICENTE ANIDO, JR., PH.D., 46. Dr. Anido has served as President and Chief
Executive Officer and as a Director of the Company since joining the Company in
March 1996. Prior to that, Dr. Anido served as President of the Americas Region
at Allergan, Inc. from June 1993, where he was responsible for that company's
commercial operations for North and South America with approximately $500
million in revenue. Prior to that, Dr. Anido spent almost 18 years at Marion
Laboratories and Marion Merrell Dow, Inc. and served as Vice President, Business
Management of its U.S. Prescription Products Division from 1991 until June 1993.
Dr. Anido holds a B.S. in Pharmacy from West Virginia University, an M.S. in
Pharmaceutical Sciences from West Virginia University and a Ph.D. in Pharmacy
Administration from the University of Missouri, Kansas City.
 
     ARTHUR REIDEL, 48. Mr. Reidel has served as a Director of the Company since
September 1997. He currently serves as President, Chief Executive Officer and
Chairman of the Board of Pharsight Corporation, a privately held software
corporation, a position he has held since April 1996, and as a director from
April 1995. Prior to that, he was a private investor/consultant from April 1995
to March 1996. From October 1994 to March 1995, he served as Vice President,
Business Development of Viewlogic Systems, Inc., a publicly held software firm.
Mr. Reidel served as a director of MacNeil-Schwendler from December 1993 until
June 1998 and he is currently a director of Formation Systems, Inc., a position
he has held since 1996. Mr. Reidel has also served as President and Chief
Executive Officer, Sunrise Test Systems, Inc., a privately held software firm,
from December 1992 to March 1994 (Viewlogic Systems, Inc. acquired Sunrise Test
Systems, Inc. in September 1994), and Vice President of Weitek Corporation from
July 1991 to December 1992. Mr. Reidel received a B.S. in mathematics from
Massachusetts Institute of Technology. Mr. Reidel currently serves as a member
of the Company's Compensation Committee.
 
BOARD MEETINGS AND COMMITTEES
 
     The Company's Board of Directors met a total of six times and acted by
unanimous written consent a total of two times during the year ended December
31, 1998. Each of the directors nominated for re-election attended at least 75%
of the aggregate of (i) total meetings of the Board and (ii) the total number of
meetings held by all committees of the Board on which he served (during the
periods that he served).
 
     The Company has a standing Audit Committee currently composed of Dr.
Chambon and Mr. Pierre Lamond. Mr. Lamond is not standing for re-election at the
annual meeting. The Audit Committee met one time in 1998. The Audit Committee
assists in selecting the independent auditors, designating the services they are
to perform and in maintaining effective communication with those auditors.
 
     The Company also has a standing Compensation Committee currently composed
of Mr. Reidel and Dr. Scott. The Compensation Committee met four times and acted
by unanimous written consent one time in 1998. The Compensation Committee
reviews and acts on matters relating to compensation levels and benefit plans
for executive officers and key employees of the Company, including salary and
stock options. The Compensation Committee is also responsible for granting stock
awards, stock options and stock appreciation rights and other awards to be made
under the Company's existing incentive compensation plans.
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<PAGE>   7
 
     Additionally, the Company established a standing Nominating Committee in
February 1999. Dr. Anido and Dr. Chambon were appointed to serve on such
committee. The Nominating Committee is responsible for putting forth names of
suitable nominees to be elected to serve as directors of the Corporation.
 
DIRECTOR COMPENSATION
 
     The Company reimburses its directors for all reasonable and necessary
travel and other incidental expenses incurred in connection with their
attendance at meetings of the Board. Directors are not currently compensated for
serving on the Board. Each individual who becomes a non-employee Board member
will receive a 20,000-share option grant on the date such individual joins the
Board. In addition, each such non-employee Board member who continues to serve
as a non-employee Board member will automatically be granted an option to
purchase 5,000 shares of Common Stock at each subsequent annual meeting,
provided such individual has served on the Board for at least six months. These
options will have an exercise price equal to 100% of the fair market value of
the Common Stock on the grant date. The shares subject to each 20,000-share
automatic option grant will vest over a four-year period, with 25% of the option
shares vesting upon completion of one year of Board service from the grant date
and the balance of the option shares vesting in equal monthly installments over
the optionee's continued period of Board service over the next three years. The
shares subject to each 5,000-share annual automatic option will vest upon the
optionee's completion of one year of Board service measured from the grant date.
In May 1998, Dr. Chambon and Mr. Lamond each received a 20,000-share grant
exercisable at $8.00 per share. In March 1999, Dr. Pazzani received a 20,000-
share grant exercisable at $4.25 per share.
 
                                   PROPOSAL 2
 
             APPROVAL OF AMENDMENT TO THE 1997 STOCK INCENTIVE PLAN
 
     The Company's stockholders are being asked to approve an amendment to the
Company's 1997 Stock Incentive Plan (the "1997 Plan") that will increase the
maximum number of shares of Common Stock authorized for issuance over the term
of the 1997 Plan by an additional 1,000,000 shares to 2,072,170 shares. The
proposed share increase will assure that a sufficient reserve of Common Stock is
available under the 1997 Plan to attract and retain the services of key
individuals essential to the Company's long-term growth and success.
 
     The 1997 Plan was adopted by the Board of Directors and stockholders in
October 1997 as the successor to the Company's 1995 Stock Option Plan (the "1995
Plan"). The 1997 Plan became effective on May 7, 1998 in connection with the
initial public offering of the Company's Common Stock, and at that time, all
outstanding options under the 1995 Plan were incorporated into the 1997 Plan and
the 1995 Plan was accordingly terminated as to all future option grants. The
amendment to the 1997 Plan for which stockholder approval is sought under this
Proposal No. Two was adopted by the Board in March 1999, subject to stockholder
approval at the Annual Meeting.
 
     The following is a summary of the principal features of the 1997 Plan as
amended, together with the applicable tax and accounting implications for the
Company and the participants. However, the summary does not purport to be a
complete description of all the provisions of the 1997 Plan. Any stockholder of
the Company who wishes to obtain a copy of the actual plan document may do so
upon written request to the Company's Chief Financial Officer at the Company's
principal executive offices in San Diego, California.
 
EQUITY INCENTIVE PROGRAMS
 
     The 1997 Plan is divided into five separate components: (i) the
Discretionary Option Grant Program under which eligible individuals in the
Company's employ or service (including officers, non-employee Board members and
consultants) may, at the discretion of the Plan Administrator, be granted
options to purchase shares of Common Stock at an exercise price not less than
100% of their fair market value on the grant date, (ii) the Stock Issuance
Program under which such individuals may, in the Plan Administrator's
discretion, be issued shares of Common Stock directly, through the purchase of
such shares at a price not less than 100% of their fair market value at the time
of issuance or as a bonus tied to the performance of services, (iii) the Salary
 
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Investment Option Grant Program which may, in the Plan Administrator's sole
discretion, be activated for one or more calendar years and, if so activated,
will allow executive officers and other highly compensated employees the
opportunity to apply a portion of their base salary to the acquisition of
special below-market stock option grants, (iv) the Automatic Option Grant
Program under which option grants will automatically be made at periodic
intervals to eligible non-employee Board members to purchase shares of Common
Stock at an exercise price equal to 100% of their fair market value on the grant
date and (v) the Director Fee Option Grant Program which may, in the Plan
Administrator's sole discretion, be activated for one or more calendar years
and, if so activated, will allow non-employee Board members the opportunity to
apply a portion of the annual retainer fee, if any, otherwise payable to them in
cash each year to the acquisition of special below-market option grants.
 
SHARE RESERVE
 
     2,072,170 shares of Common Stock have been reserved for issuance over the
10 year term of the 1997 Plan, assuming stockholder approval of the
1,000,000-share increase, which forms part of Proposal No. Two. As of March 31,
1999, options for 851,839 shares of Common Stock were outstanding. 1,188,182
shares remain available for future option grants (assuming stockholder approval
of the 1,000,000-share increase, which forms part of Proposal No. Two) and
32,449 shares have been issued under the 1997 Plan. Without the proposed
increase, only 188,182 shares would be available for future grant.
 
     Should any option terminate prior to exercise in full, the shares subject
to the unexercised portion of that option will be available for subsequent
option grants. In addition, any unvested shares issued under the Plan and
subsequently repurchased by the Company at the option exercise or direct issue
price paid per share pursuant to the Company's repurchase rights under the Plan
will be added back to the number of shares of Common Stock reserved for issuance
under the Plan and will accordingly be available for reissuance through one or
more subsequent option grants or direct stock issuances made under the Plan.
However, shares subject to any option surrendered in accordance with the stock
appreciation right provisions of the 1997 Plan will not be available for
subsequent issuance.
 
     In no event may any one participant in the 1997 Plan be granted stock
options, separately exercisable stock appreciation rights and direct stock
issuances for more than 500,000 shares in the aggregate per calendar year under
the 1997 Plan.
 
CHANGES IN CAPITALIZATION
 
     In the event any change is made to the outstanding shares of Common Stock
by reason of any recapitalization, stock dividend, stock split, combination of
shares, exchange of shares or other change in corporate structure effected
without the Company's receipt of consideration, appropriate adjustments will be
made to (i) the maximum number and class of securities issuable under the 1997
Plan, (ii) the maximum number and class of securities for which any one
participant may be granted stock options, separately exercisable stock
appreciation rights and direct stock issuances under the 1997 Plan, (iii) the
number and class of securities for which option grants will subsequently be made
under the Automatic Option Grant Program to each newly-elected or continuing
non-employee Board member and (iv) the number and class of securities and the
exercise price per share in effect under each outstanding option under the Plan.
All such adjustments will be designed to preclude the enlargement or dilution of
participant rights and benefits under the Option Plan.
 
ELIGIBILITY
 
     Employees, non-employee Board members, and independent consultants and
advisors to the Company and its subsidiaries (whether now existing or
subsequently established) will be eligible to participate in the Discretionary
Option Grant and Stock Issuance Programs. Non-employee members of the Board will
also be eligible to participate in the Automatic Option Grant Program.
 
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<PAGE>   9
 
     As of March 31, 1999, six executive officers, five non-employee Board
members and approximately 91 other employees were eligible to participate in the
1997 Plan, and the five non-employee Board members were also eligible to
participate in the Automatic Option Grant Program.
 
VALUATION
 
     The fair market value per share of Common Stock on any relevant date under
the 1997 Plan will be the closing selling price per share on that date on the
Nasdaq National Market. On March 31, 1999, the closing selling price of the
Company's Common Stock was $3.75 per share.
 
DISCRETIONARY OPTION GRANT AND STOCK ISSUANCE PROGRAMS
 
     The Discretionary Option Grant Program and the Stock Issuance Program will
be administered by the Compensation Committee of the Company. The Compensation
Committee as Plan Administrator will have complete discretion to determine which
eligible individuals are to receive option grants or stock issuances under those
programs, the time or times when such option grants or stock issuances are to be
made, the number of shares subject to each such grant or issuance, the status of
any granted option as either an incentive stock option or a non-statutory stock
option under the Federal tax laws, the vesting schedule to be in effect for the
option grant or stock issuance and the maximum term for which any granted option
is to remain outstanding. The Compensation Committee will also have the
exclusive authority to select the executive officers and other highly
compensated employees who may participate in the Salary Investment Option Grant
Program in the event that program is activated for one or more calendar years,
but neither the Compensation Committee nor the Board will exercise any
administrative discretion with respect to option grants under the Salary
Investment Option Grant Program or under the Automatic Option Grant or Director
Fee Option Grant Program for the non-employee Board members. All grants under
those three latter programs will be made in strict compliance with the express
provisions of each such program.
 
     The exercise price for the shares of Common Stock subject to option grants
made under the 1997 Plan may be paid in cash or in shares of Common Stock valued
at fair market value on the exercise date. The option may also be exercised
through a same-day sale program without any cash outlay by the optionee. In
addition, the Plan Administrator may provide financial assistance to one or more
optionees in the exercise of their outstanding options or the purchase of their
unvested shares by allowing such individuals to deliver a full-recourse,
interest-bearing promissory note in payment of the exercise price and any
associated withholding taxes incurred in connection with such exercise or
purchase.
 
     The Plan Administrator will have the authority, with the consent of the
affected option holders, to effect the cancellation of outstanding options under
the Discretionary Option Grant Program (including options incorporated from the
1995 Plan) in return for the grant of new options for the same or different
number of option shares with an exercise price per share based upon the fair
market value of the Common Stock on the new grant date.
 
     Stock appreciation rights are authorized for issuance under the
Discretionary Option Grant Program which provide the holders with the election
to surrender their outstanding options for an appreciation distribution from the
Company equal to the excess of (i) the fair market value of the vested shares of
Common Stock subject to the surrendered option over (ii) the aggregate exercise
price payable for such shares. Such appreciation distribution may be made in
cash or in shares of Common Stock. None of the incorporated options from the
1995 Plan contain any stock appreciation rights.
 
     In the event that the Company is acquired by merger or asset sale, each
outstanding option under the Discretionary Option Grant Program which is not to
be assumed by the successor corporation will automatically accelerate in full,
and all unvested shares under the Discretionary Option Grant and Stock Issuance
Programs will immediately vest, except to the extent the Company's repurchase
rights with respect to those shares are to be assigned to the successor
corporation. The Plan Administrator will have complete discretion to grant one
or more options under the Discretionary Option Grant Program which will become
fully exercisable for all the option shares in the event those options are
assumed in the acquisition and the optionee's service with the Company or the
acquiring entity terminates within a designated period following
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<PAGE>   10
 
such acquisition. The vesting of outstanding shares under the Stock Issuance
Program may be accelerated upon similar terms and conditions. The Plan
Administrator will also have the authority to grant options which will
immediately vest upon an acquisition of the Company, whether or not those
options are assumed by the successor corporation. The Plan Administrator is also
authorized under the Discretionary Option Grant and Stock Issuance Programs to
grant options and to structure repurchase rights so that the shares subject to
those options or repurchase rights will immediately vest in connection with a
change in control of the Company (whether by successful tender offer for more
than 50% of the outstanding voting stock or a change in the majority of the
Board by reason of one or more contested elections for Board membership), with
such vesting to occur either at the time of such change in control or upon the
subsequent termination of the individual's service within a designated period
following such change in control. The options incorporated from the 1995 Plan
will similarly accelerate and immediately vest upon an acquisition of the
Company by merger or asset sale, unless those options are assumed by the
successor entity.
 
SALARY INVESTMENT OPTION GRANT PROGRAM
 
     In the event the Plan Administrator elects to activate the Salary
Investment Option Grant Program for one or more calendar years, each executive
officer and other highly compensated employee of the Company selected for
participation may elect, prior to the start of the calendar year, to reduce his
or her base salary for that calendar year by a specified dollar amount not less
than $10,000 nor more than $50,000. If such election is approved by the Plan
Administrator, the individual will automatically be granted, on the first
trading day in January of the calendar year for which that salary reduction is
to be in effect, a non-statutory option to purchase that number of shares of
Common Stock determined by dividing the salary reduction amount by two-thirds of
the fair market value per share of Common Stock on the grant date. The option
will be exercisable at a price per share equal to one-third of the fair market
value of the option shares on the grant date. As a result, the total spread on
the option shares at the time of grant (the fair market value of the option
shares on the grant date less the aggregate exercise price payable for those
shares) will be equal to the amount of salary invested in that option. The
option will vest in a series of 12 equal monthly installments over the calendar
year for which the salary reduction is to be in effect and will be subject to
full and immediate vesting upon certain changes in the ownership or control of
the Company.
 
AUTOMATIC OPTION GRANT PROGRAM
 
     The Company has previously granted to certain non-employee Board members an
option to purchase 20,000 shares of Common Stock, and each non-employee Board
member who is serving as such on the Plan Effective Date and who has not
received such a grant will automatically receive an option at that time to
purchase 20,000 shares of Common Stock. Each individual who first becomes a
non-employee Board member at any time after the Plan Effective Date will also
receive a 20,000-share option grant on the date such individual joins the Board.
In addition and on the date of each Annual Stockholders Meeting held after the
Plan Effective Date, each such non-employee Board member who is to continue to
serve as a non-employee Board member will automatically be granted an option to
purchase 5,000 shares of Common Stock, provided such individual has served on
the Board for at least six months.
 
     Each automatic grant for the non-employee Board members will have a term of
10 years, subject to earlier termination following the optionee's cessation of
Board service. Each automatic option will be immediately exercisable for all of
the option shares; however, any unvested shares purchased under the option will
be subject to repurchase by the Company, at the exercise price paid per share,
should the optionee cease Board service prior to vesting in those shares. The
shares subject to each initial 20,000-share automatic option grant will vest
over a four-year period, as follows: (i) 25% of the option shares upon the
optionee's completion of one year of Board service measured from the grant date
and (ii) the balance of the option shares in a series of 36 successive equal
monthly installments upon the optionee's completion of each additional month of
service measured from the first anniversary of the grant date. The shares
subject to each annual 5,000-share grant will vest upon the optionee's
completion of one year of Board service measured from the grant date. However,
the shares subject to each automatic option grant will immediately vest in full
upon certain changes in control or ownership of the Company or upon the
optionee's death or disability while a Board member.
 
                                        7
<PAGE>   11
 
DIRECTOR FEE OPTION GRANT PROGRAM
 
     Should the Director Fee Option Grant Program be activated in the future,
each non-employee Board member will have the opportunity to apply all or a
portion of any annual retainer fee otherwise payable in cash to the acquisition
of a below-market option grant. The option grant will automatically be made on
the first trading day in January in the year for which the retainer fee would
otherwise be payable in cash. The option will have an exercise price per share
equal to one-third of the fair market value of the option shares on the grant
date, and the number of shares subject to the option will be determined by
dividing the amount of the retainer fee applied to the program by two-thirds of
the fair market value per share of Common Stock on the grant date. As a result,
the total spread on the option (the fair market value of the option shares on
the grant date less the aggregate exercise price payable for those shares) will
be equal to the portion of the retainer fee invested in that option. The option
will become exercisable for the option shares in a series of 12 equal monthly
installments over the calendar year for which the election is to be in effect.
However, the option will become immediately exercisable for all the option
shares upon (i) certain changes in the ownership or control of the Company or
(ii) the death or disability of the optionee while serving as a Board member.
 
GENERAL PROVISIONS
 
     Acceleration. The shares subject to each option under the Salary Investment
Option Grant, Automatic Option Grant and Director Fee Option Grant Programs will
immediately vest upon (i) an acquisition of the Company by merger or asset sale
or (ii) the successful completion of a tender offer for more than 50% of the
Company's outstanding voting stock or a change in the majority of the Board
effected through one or more contested elections for Board membership.
 
     Stock Appreciation Rights. Limited stock appreciation rights will
automatically be included as part of each grant made under the Automatic Option
Grant, Salary Investment Option Grant and Director Fee Option Grant Programs and
may be granted to one or more officers of the Company as part of their option
grants under the Discretionary Option Grant Program. Options with such a limited
stock appreciation right may be surrendered to the Company upon the successful
completion of a hostile tender offer for more than 50% of the Company's
outstanding voting stock. In return for the surrendered option, the optionee
will be entitled to a cash distribution from the Company in an amount per
surrendered option share equal to the excess of (i) the highest price per share
of Common Stock paid in connection with the tender offer over (ii) the exercise
price payable for such share.
 
     Financial Assistance. The Plan Administrator may institute a loan program
to assist one or more participants in financing the exercise of outstanding
options or the purchase of shares under the Discretionary Option Grant or Stock
Issuance Program. The Plan Administrator will have complete discretion to
determine the terms of any such financial assistance. However, the maximum
amount of financing provided any individual may not exceed the cash
consideration payable for the issued shares plus all applicable taxes. Any such
financing may be subject to forgiveness in whole or in part, at the discretion
of the Plan Administrator, over the participant's period of service.
 
     Special Tax Election. The Plan Administrator may provide one or more
holders of options or unvested shares with the right to have the Company
withhold a portion of the shares otherwise issuable to such individuals in
satisfaction of the tax liability incurred by such individuals in connection
with the exercise of those options or the vesting of those shares.
Alternatively, the Plan Administrator may allow such individuals to deliver
previously acquired shares of Common Stock in payment of such tax liability.
 
     Amendment and Termination. The Board may amend or modify the 1997 Plan at
any time, subject to any required stockholder approval. The 1997 Plan will
terminate on the earliest of (i) October 31, 2007, (ii) the date on which all
shares available for issuance under the 1997 Plan have been issued as fully
vested shares or (iii) the termination of all outstanding options in connection
with certain changes in control or ownership of the Company.
 
                                        8
<PAGE>   12
 
STOCK AWARDS
 
     During the period from May 8, 1998 (the effective date of the Company's
initial public offering) through March 31, 1999, under the 1997 Plan, the
Company granted to non-employee Board members, Dr. Chambon, Mr. Lamond and Dr.
Pazzani, options to purchase 20,000 shares of stock at exercise prices of $4.25
to $8.00 per share. The Company granted to executive officer, Dennis Smith,
options to purchase 75,000 shares of stock at an exercise price of $4.13 per
share, and to all employees (excluding non-employee directors and executive
officers) and consultants as a group, options to purchase 274,000 shares of
stock at exercise prices of $4.00 to $6.00 per share. No options were granted to
the Company's Chief Executive Officer and each of the other four most highly
compensated officers of the Company (reference pg. 15, Summary Compensation
Table, for a listing of the "Named Executive Officers").
 
NEW PLAN BENEFITS
 
     As of March 31, 1999, no options have been granted and no direct stock
issuances have been made on the basis of the proposed share increase, which
forms part of this Proposal No. Two.
 
FEDERAL INCOME TAX CONSEQUENCES
 
     Options granted under the 1997 Plan may be either incentive stock options
which satisfy the requirements of Section 422 of the Internal Revenue Code or
non-statutory options which are not intended to meet such requirements. The
Federal income tax treatment for the two types of options differs as follows:
 
     Incentive Options. No taxable income is recognized by the optionee at the
time of the option grant, and no taxable income is generally recognized at the
time the option is exercised. The optionee will, however, recognize taxable
income in the year in which the purchased shares are sold or otherwise made the
subject of a taxable disposition. For Federal tax purposes, dispositions are
divided into two categories: qualifying and disqualifying. A qualifying
disposition occurs if the sale or other disposition is made after the optionee
has held the shares for more than two (2) years after the option grant date and
more than one (1) year after the exercise date. If either of these two holding
periods is not satisfied, then a disqualifying disposition will result.
 
     Upon a qualifying disposition, the optionee will recognize long-term
capital gain in an amount equal to the excess of (i) the amount realized upon
the sale or other disposition of the purchased shares over (ii) the exercise
price paid for the shares. If there is a disqualifying disposition of the
shares, then the excess of (i) the fair market value of those shares on the
exercise date over (ii) the exercise price paid for the shares will be taxable
as ordinary income to the optionee. Any additional gain or loss recognized upon
the disposition will be recognized as a capital gain or loss by the optionee.
 
     If the optionee makes a disqualifying disposition of the purchased shares,
then the Company will be entitled to an income tax deduction, for the taxable
year in which such disposition occurs, equal to the excess of (i) the fair
market value of such shares on the option exercise date over (ii) the exercise
price paid for the shares. If the optionee makes a qualifying disposition, the
Company will not be entitled to any income tax deduction.
 
     Non-Statutory Options. No taxable income is recognized by an optionee upon
the grant of a non-statutory option. The optionee will in general recognize
ordinary income, in the year in which the option is exercised, equal to the
excess of the fair market value of the purchased shares on the exercise date
over the exercise price paid for the shares, and the optionee will be required
to satisfy the tax withholding requirements applicable to such income.
 
     If the shares acquired upon exercise of the non-statutory option are
unvested and subject to repurchase by the Company in the event of the optionee's
termination of service prior to vesting in those shares, then the optionee will
not recognize any taxable income at the time of exercise but will have to report
as ordinary income, as and when the Company's repurchase right lapses, an amount
equal to the excess of (i) the fair market value of the shares on the date the
repurchase right lapses over (ii) the exercise price paid for the shares. The
optionee may, however, elect under Section 83(b) of the Internal Revenue Code to
include as ordinary income in the year of exercise of the option an amount equal
to the excess of (i) the fair market value
                                        9
<PAGE>   13
 
of the purchased shares on the exercise date over (ii) the exercise price paid
for such shares. If the Section 83(b) election is made, the optionee will not
recognize any additional income as and when the repurchase right lapses.
 
     The Company will be entitled to an income tax deduction equal to the amount
of ordinary income recognized by the optionee with respect to the exercised
non-statutory option. The deduction will in general be allowed for the taxable
year of the Company in which such ordinary income is recognized by the optionee.
 
     Stock Appreciation Rights. An optionee who is granted a stock appreciation
right will recognize ordinary income in the year of exercise equal to the amount
of the appreciation distribution. The Company will be entitled to an income tax
deduction equal to such distribution for the taxable year in which the ordinary
income is recognized by the optionee.
 
     Direct Stock Issuance. The tax principles applicable to direct stock
issuances under the 1997 Plan will be substantially the same as those summarized
above for the exercise of non-statutory option grants.
 
DEDUCTIBILITY OF EXECUTIVE COMPENSATION
 
     The Company anticipates that any compensation deemed paid by it in
connection with the disqualifying disposition of incentive stock option shares
or the exercise of non-statutory options granted with exercise prices equal to
the fair market value of the shares on the grant date will qualify as
performance-based compensation for purposes of Code Section 162(m) and will not
have to be taken into account for purposes of the $1 million limitation per
covered individual on the deductibility of the compensation paid to certain
executive officers of the Company. Accordingly, all compensation deemed paid
under the 1997 Plan will remain deductible by the Company without limitation
under Code Section 162(m).
 
ACCOUNTING TREATMENT
 
     Option grants or stock issuances with exercise or issue prices less than
the fair market value of the shares on the grant or issue date will result in a
direct compensation expense to the Company's earnings equal to the difference
between the exercise or issue price and the fair market value of the shares on
the grant or issue date. Such expense will be accruable by the Company over the
period that the option shares or issued shares are to vest. Option grants or
stock issuances at 100% of fair market value will not result in any direct
charge to the Company's earnings. However, the fair value of those options is
required to be disclosed in the notes to the Company's financial statements, and
the Company must also disclose, in pro-forma statements to the Company's
financial statements, the impact those options would have upon the Company's
reported earnings were the value of those options at the time of grant treated
as compensation expense. Whether or not granted at a discount, the number of
outstanding options may be a factor in determining the Company's earnings per
share on a fully-diluted basis.
 
     Should one or more optionees be granted stock appreciation rights which
have no conditions upon exercisability other than a service or employment
requirement, then such rights will result in compensation expense to the
Company's earnings.
 
STOCKHOLDER APPROVAL
 
     The affirmative vote of a majority of the outstanding voting shares of the
Company present or represented and entitled to vote at the 1999 Annual Meeting
is required for approval of the amendment to the 1997 Plan. Should such
stockholder approval not be obtained, then the 1,000,000-share increase to the
share reserve will not be implemented, and any stock options granted on the
basis of the 1,000,000-share increase to the 1997 Plan will immediately
terminate without becoming exercisable for the shares of Common Stock subject to
those options, and no additional options will be granted on the basis of such
share increase. The 1997 Plan will, however, continue to remain in effect, and
option grants and direct stock issuances may continue to be made pursuant to the
provisions of the 1997 Plan in effect prior to the amendments summarized in this
Proposal No. Two until the available reserve of Common Stock as last approved by
the stockholders has been issued pursuant to option grants and direct stock
issuances made under the 1997 Plan.
 
                                       10
<PAGE>   14
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
     The Board of Directors recommends that the stockholders vote FOR the
amendment to the 1997 Plan.
 
                                   PROPOSAL 3
 
                 APPROVAL OF SELECTION OF INDEPENDENT AUDITORS
 
     The Company is asking the stockholders to ratify the selection of Ernst &
Young LLP as the Company's independent auditors for the year ending December 31,
1999.
 
VOTE REQUIRED
 
     The affirmative vote of a majority of the stockholders represented and
voting at the Annual Meeting will be required to ratify the selection of Ernst &
Young LLP. In the event the stockholders fail to ratify the appointment, the
Board of Directors will reconsider its selection. Even if the selection is
ratified, the Board of Directors, in its discretion, may direct the appointment
of a different independent accounting firm at any time during the year if it
believes such a change would be in CombiChem's and its stockholders' best
interests.
 
     Representatives of Ernst & Young LLP are expected to be present at the
Annual Meeting, will have an opportunity to make a statement if they desire to
do so and will be available to respond to appropriate questions.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
     The Board of Directors unanimously recommends a vote FOR the ratification
and approval of the selection of Ernst & Young LLP to serve as CombiChem's
independent auditors for the year ending December 31, 1999.
 
                                       11
<PAGE>   15
 
                            OWNERSHIP OF SECURITIES
 
     The following table sets forth certain information known to the Company
regarding the beneficial ownership of the Common Stock as of March 31, 1999, by
(i) all persons who are beneficial owners of 5% or more of the Company's Common
Stock, (ii) each director of the Company, (iii) each of the Company's officers
named under "Executive Compensation and Other Information -- Summary of Cash and
Certain Other Compensation" and (iv) all directors and executive officers of the
Company as a group. Except as indicated in the footnotes to this table, the
persons named in the table have sole voting and investment power with respect to
all shares of Common Stock shown as beneficially owned by them. Share ownership
in each case includes shares issuable upon exercise of certain outstanding
options as described in the footnotes below. The address for those individuals
for which an address is not otherwise indicated is: 9050 Camino Santa Fe, San
Diego, CA 92121. Percentage of ownership is calculated pursuant to Commission
Rule 13d-3(d)(1).
 
<TABLE>
<CAPTION>
                                                                             PERCENTAGE
                                             SHARES                          OF SHARES
                                          BENEFICIALLY       OPTIONS        BENEFICIALLY
  NAME AND ADDRESS OF BENEFICIAL OWNER       OWNED        EXERCISABLE(1)       OWNED
  ------------------------------------    ------------    --------------    ------------
<S>                                       <C>             <C>               <C>
Sprout Capital VII, L.P. and affiliated
  entities(2)...........................   1,501,727           20,000           11.3%
  3000 Sand Hill Road
  Building 3, Suite 170
  Menlo Park, CA 94025
Sequoia Capital VI and affiliated
  entities(3)...........................   1,237,999           20,000            9.3%
  3000 Sand Hill Road
  Building 4, Suite 280
  Menlo Park, CA 94025
Elan International Services Ltd.........   1,250,000                0            9.3%
  102 St. James Court
  Flatts Smiths, FL04
  Bermuda
Brinson MAP Venture Capital Fund III and
  affiliated entities(4)................     956,452                0            7.1%
  209 S. LaSalle Street
  Chicago, IL 60604-1295
Sorrento Growth Partners I, L.P. and
  affiliated entities(5)................     750,867                0            5.6%
  4370 La Jolla Village Dr., Suite 1040
  San Diego, CA 92122
Pierre R. Lamond........................   1,237,999           20,000            9.3%
Philippe O. Chambon, M.D., Ph.D. .......   1,501,727           20,000           11.3%
Michael Pazzani, Ph.D...................           0           20,000              *
Arthur Reidel...........................      20,000           20,000              *
William Scott, Ph.D. ...................           0           20,000              *
Vicente Anido, Jr., Ph.D. ..............     480,417          100,001            4.3%
Karin Eastham...........................      91,875                0              *
Klaus Gubernator, Ph.D. ................      52,500                0              *
Lee R. McCracken(6).....................      93,750           15,000              *
Peter L. Myers, Ph.D. ..................     222,500           50,001            2.0%
All directors and executive officers as
  a group (10 persons)..................   3,700,770          340,002           29.3%
</TABLE>
 
- ---------------
 *  Represents beneficial ownership of less than 1% of the outstanding shares of
    the Company's Common Stock.
 
(1) Represents options exercisable within 60 days of March 31, 1999.
 
(2) Includes 1,386,329 shares purchased by Sprout Capital VII, L.P., which are
    held in a voting trust of which First Union Trust Company, National
    Association ("First Union"), is the voting trustee. First Union has sole
    voting power of these shares. The address for First Union is One Rodney
    Square,
                                       12
<PAGE>   16
 
    920 King Street, Wilmington, Delaware 19801. Also includes 115,398 shares
    purchased by DLJ Capital Corporation. DLJ Capital Corporation is the
    managing general partner of Sprout Capital VII, L.P. Dr. Chambon is a
    Director of the Company, a general partner of Sprout Capital VII, L.P. and
    Divisional Vice President of DLJ Capital Corporation. Dr. Chambon disclaims
    beneficial ownership of the 1,386,329 shares and the 115,398 shares except
    to the extent of his pecuniary interest therein.
 
(3) Includes 1,109,962 shares held by Sequoia Capital VI, 60,988 shares held by
    Sequoia Technology Partners VI, 33,012 shares held by Sequoia XXIV and
    15,780 shares held by Sequoia 1995, each of which is affiliated with Sequoia
    Partners. Sequoia Partners is the general partner of Sequoia Capital VI.
    Sequoia Partners has eight general partners, who are also the general
    partners of Sequoia Technology Partners VI. Also includes 16,613 shares, 913
    shares and 731 shares held by Sequoia Capital VI, Sequoia Technology
    Partners VI and Sequoia XXIV, respectively, issuable upon exercise of
    warrants exercisable within 60 days of February 28, 1998. Mr. Lamond is a
    Director of the Company and a general partner of Sequoia Partners. Mr.
    Lamond disclaims beneficial ownership of such shares except to the extent of
    his pecuniary interest therein.
 
(4) Includes 134,113 shares purchased by the First National Bank of Chicago as
    Custodian to the Brinson Trust Company as Trustee of the Brinson MAP Venture
    Capital Fund III and 822,340 shares purchased by The First National Bank of
    Chicago as Custodian to the Brinson Venture Capital Fund III, L.P.
 
(5) Includes 249,803 shares held by Sorrento Ventures II, L.P. and 501,064
    shares held by Sorrento Growth Partners I, L.P.
 
(6) Includes 8,750 shares held by the Rufus L. McCracken Trust, dated 6/21/91,
    of which Mr. McCracken is the sole Trustee.
 
                                       13
<PAGE>   17
 
                                   MANAGEMENT
 
     The executive officers of the Company as of March 31, 1999, are as follows:
 
<TABLE>
<CAPTION>
           NAME             AGE                     POSITION
           ----             ---                     --------
<S>                         <C>   <C>
Vicente Anido, Jr., Ph.D.   46    President, Chief Executive Officer and
                                  Director
Peter L. Myers, Ph.D.       55    Vice President, Chief Scientific Officer,
                                  Chief Operating Officer and Director
Lee R. McCracken            41    Senior Vice President, Corporate Development
                                  and New Business Ventures
Karin Eastham               49    Vice President, Finance and Administration
                                  and Chief Financial Officer
Klaus Gubernator, Ph.D.     45    Vice President, Special Projects
Dennis H. Smith, Ph.D.      56    Vice President, Software R&D
</TABLE>
 
     VICENTE ANIDO, JR., PH.D. Dr. Anido is a director of the Company. See
"Election of Directors" for a discussion of Dr. Anido's business experience.
 
     PETER L. MYERS, PH.D. Dr. Myers is a director of the Company. See "Election
of Directors" for a discussion of Dr. Myers' business experience.
 
     LEE R. MCCRACKEN. Mr. McCracken has served as Senior Vice President,
Corporate Development and New Business Ventures since January 1999. Previously,
Mr. McCracken held the position of Vice President, Business Development, a
position he held since joining the Company in May 1996. Prior to joining the
Company, Mr. McCracken served as Vice President, Business Development at Watson
Laboratories, the operating subsidiary of Watson Pharmaceuticals, from January
1996 through May 1996. Prior to that, Mr. McCracken served as Managing Director
of Pacific Pharma and as Director, Business Development, for the Americas Region
at Allergan, Inc. from May 1992 through December 1995. Prior to entering the
pharmaceutical industry, Mr. McCracken was a venture capitalist with 3i Capital
and Union Venture Corporation. Mr. McCracken received a B.S. in Marketing from
Santa Clara University, an M.S. in Computer Science from the University of
Dayton and an M.B.A. from The Anderson School at UCLA.
 
     KARIN EASTHAM. Ms. Eastham joined the Company as Vice President, Finance
and Administration and Chief Financial Officer in April 1997. Prior to joining
the Company, Ms. Eastham served as Vice President, Finance and Administration
and Chief Financial Officer of Cytel Corporation, a drug research and
development company, from October 1992 through April 1997. Prior to that, Ms.
Eastham was Vice President, Finance and Administration of Pritsker Corporation,
a simulation-based computer software company, from May 1990 through October
1992. Ms. Eastham received a B.S. in Accounting and an M.B.A. from Indiana
University. She is a Certified Public Accountant.
 
     KLAUS GUBERNATOR, PH.D. Dr. Gubernator joined the Company in August 1997 as
Vice President, Special Projects. Prior to joining the Company, he served as
Research Section Head in Pharmaceutical Research at F. Hoffmann-La Roche Ltd. in
Basel, Switzerland from January 1987 to June 1997, contributing to
cardiovascular and antibacterial projects as well as developing structure-based
design and bioinformatics technologies. Dr. Gubernator received his
undergraduate in 1979, and his Ph.D. degree in 1982, in Chemistry from the
University of Heidelberg.
 
     DENNIS H. SMITH, PH.D. Dr. Smith joined the Company in October 1998 as Vice
President, Software R&D. Prior to joining the Company, Dr. Smith held a variety
of senior research and development management positions with MDL Information
Systems, Inc. from 1986 through October, 1998, including his most recent
position of Senior Vice President and Chief Scientist. MDL provides software
systems, databases and other services to help producers and users of chemical
and biological products manage and analyze research data. While at MDL, Dr.
Smith led major product development efforts, aimed at providing chemical
database software and systems for pharmaceutical, agrochemical and biotechnology
companies around the world. Dr. Smith received his Ph.D. in Chemistry at the
University of California, Berkeley. He received his B.S. in Chemistry from the
Massachusetts Institute of Technology.
 
                                       14
<PAGE>   18
 
                  EXECUTIVE COMPENSATION AND OTHER INFORMATION
 
SUMMARY OF CASH AND CERTAIN OTHER COMPENSATION
 
     The following table sets forth the aggregate compensation earned by the
Company's President and Chief Executive Officer and each of the other four most
highly compensated executive officers whose salary and bonus for 1998 exceeded
$100,000 (the "Named Executive Officers") for services rendered in all
capacities to the Company for the year ended December 31, 1998:
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                     LONG-TERM
                                                                                   COMPENSATION
                                                                                      AWARDS
                                                  ANNUAL                          ---------------
                                               COMPENSATION          OTHER          SECURITIES
                                            -------------------      ANNUAL         UNDERLYING       ALL OTHER
    NAME AND PRINCIPAL POSITION      YEAR   SALARY(1)    BONUS    COMPENSATION    OPTIONS/SARs(#)   COMPENSATION
    ---------------------------      ----   ---------   -------   ------------    ---------------   ------------
<S>                                  <C>    <C>         <C>       <C>             <C>               <C>
VICENTE ANIDO, JR., PH.D. (2)....... 1998   $287,712    $64,735     $48,691(3)(4)           0          $2,240(5)
  President, Chief Executive Officer 1997    273,593     58,227           0           100,001               0
  and Director                       1996    200,417     55,226           0           422,417               0
PETER L. MYERS, PH.D.(6)............ 1998    234,605     52,786          --                 0           3,855(5)
  Vice President, Chief Scientific   1997    225,582     42,297           0            50,001           3,855(5)
  Officer, Chief Operating Officer   1996    215,250     43,050          --                 0           4,960(5)
  and Director
LEE R. McCRACKEN(7)................. 1998    158,036     23,705      34,872(4)              0               0
  Senior Vice President,             1997    150,510     33,112      59,739(8)         12,500               0
  Corporate Development and          1996    101,740     16,917          --            72,500               0
  New Business Ventures
KARIN EASTHAM(9).................... 1998    192,200     30,752          --                 0               0
  Vice President, Finance and        1997    133,181     26,350           0            91,875               0
  Administration and Chief Financial
  Officer
KLAUS GUBERNATOR, Ph.D.(10)......... 1998    143,961     28,792          --                 0               0
  Vice President, Special Projects   1997     51,974     10,575           0            52,500               0
</TABLE>
 
- ---------------
 (1) Includes amounts deferred under the Company's 401(k) Plan.
 
 (2) Dr. Anido was hired in March 1996.
 
 (3) Includes $48,000 related to the forgiveness of debt.
 
 (4) Includes amounts reimbursed for the payment of taxes.
 
 (5) Payments for life insurance premiums.
 
 (6) Dr. Myers served as the Company's acting Chief Executive Officer from
     August 1995 until March 1996.
 
 (7) Mr. McCracken was hired in May 1996.
 
 (8) Payments to cover relocation expenses.
 
 (9) Ms. Eastham was hired in April 1997.
 
(10) Dr. Gubernator was hired in July 1997.
 
STOCK OPTIONS
 
     No stock options or stock appreciation rights ("SARs") were granted to, or
exercised by, Named Executive Officers during 1998.
 
                                       15
<PAGE>   19
 
     The following table provides information concerning the value of
unexercised options held by each of the Named Executive Officers as of December
31, 1998. No SARs were exercised during 1998 or outstanding as of December 31,
1998.
 
               AGGREGATE OPTION EXERCISES IN LAST FISCAL YEAR AND
                         FISCAL YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                   NUMBER OF SECURITIES
                                                        UNDERLYING                  VALUE OF UNEXERCISED
                                                  UNEXERCISED OPTIONS AT          IN-THE-MONEY OPTIONS AT
                                                    DECEMBER 31, 1998               DECEMBER 31, 1998(2)
                                              ------------------------------   ------------------------------
                    NAME                      EXERCISABLE(1)   UNEXERCISABLE   EXERCISABLE(1)   UNEXERCISABLE
                    ----                      --------------   -------------   --------------   -------------
<S>                                           <C>              <C>             <C>              <C>
Vicente Anido, Jr., Ph.D. ..................     100,001             0            $31,300            $0
Peter L. Myers, Ph.D. ......................      50,001             0             15,650             0
Lee R. McCracken............................           0             0                  0             0
Karin Eastham...............................           0             0                  0             0
Klaus Gubernator, Ph.D. ....................           0             0                  0             0
</TABLE>
 
- ---------------
(1) The options are immediately exercisable, but any shares purchased thereunder
    will be subject to repurchase by the Company, at the original option
    exercise price paid per share, should the employee leave the Company prior
    to vesting in the shares. As of December 31, 1998, none of these shares had
    vested.
 
(2) "Value" is calculated in this table as the fair market price of the Common
    Stock at fiscal year-end ($4.31) less exercise price.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     During the year ended December 31, 1998, the Compensation Committee of the
Company's Board established the levels of compensation for the Company's
executive officers. The current members of the Company's Compensation Committee
are Mr. Reidel and Dr. Scott. See "Certain Transactions."
 
EMPLOYMENT ARRANGEMENTS AND CHANGE OF CONTROL ARRANGEMENTS
 
     In March 1996, the Company and Dr. Anido entered into an agreement whereby
Dr. Anido is employed as President and Chief Executive Officer of the Company.
Pursuant to his agreement, Dr. Anido was to receive an annual base salary of
$260,000 (his current salary is $302,092), which would be reviewed annually by
the Board of Directors, and would be eligible for a bonus of up to 25%
(currently 35%) of his annual base salary to be awarded at the discretion of the
Board of Directors. In the event the Company terminates Dr. Anido's employment
without "cause," Dr. Anido will be entitled to receive an aggregate severance
benefit of 12 months of his base salary and benefits less amounts received by
Dr. Anido from other full-time employment during that period. In addition,
pursuant to his employment agreement Dr. Anido received options to purchase
420,000 shares of Common Stock with an exercise price of $0.30 per share. The
shares subject to the option vest over Dr. Anido's four-year period of service
with the Company measured from the option grant date. Dr. Anido's employment
agreement also provides Dr. Anido with a right to maintain his pro rata interest
in the Company by purchasing new securities issued in a financing other than a
public offering, subject to certain exceptions.
 
     In March 1995, the Company and Dr. Myers entered into an agreement whereby
Dr. Myers is employed as Chief Scientific Officer and Chief Operating Officer of
the Company. Pursuant to his agreement, Dr. Myers (i) received a signing bonus
of $26,250 towards the purchase of Company stock, (ii) was to receive an annual
base salary of $210,000 (his current annual salary is $250,324), which would be
reviewed annually by the President and Chief Executive Officer, and (iii) would
be eligible for a bonus of up to 25% of his annual base salary to be awarded at
the discretion of the Board of Directors. In connection with the employment
agreement, Dr. Myers was provided a home loan. In the event the Company
terminates Dr. Myers' employment without "cause," Dr. Myers will be entitled to
receive an aggregate severance benefit of nine months of his base salary and
benefits, unless he obtains full-time employment prior to the end of that
 
                                       16
<PAGE>   20
 
period, and nine months accelerated vesting to be applied to any vesting
requirements under any stock option or stock purchase agreements outstanding
between Dr. Myers and the Company at the time of his termination without cause.
Simultaneous with the execution of Dr. Myers' employment agreement, the Company
and Dr. Myers entered into a Stock Purchase Agreement whereby Dr. Myers
purchased 87,500 shares of Common Stock at $0.30 per share. Those shares vest
over Dr. Myers' four-year period of service with the Company measured from the
option grant date.
 
     In May 1996, the Company and Mr. McCracken entered into an agreement
whereby he is employed as Vice President, Business Development of the Company.
Pursuant to his agreement, Mr. McCracken received a signing bonus of $10,000 and
was to receive an annual base salary of $145,000 (his current salary is
$195,000), which would be reviewed annually by the President and Chief Executive
Officer. In addition, Mr. McCracken would be eligible for a bonus of up to 20%
of his annual base salary. In the event the Company terminates Mr. McCracken's
employment without "cause," Mr. McCracken will be entitled to receive an
aggregate severance benefit of nine months of his base salary and benefits.
Simultaneous with the execution of Mr. McCracken's employment agreement, the
Company and Mr. McCracken entered into a stock option agreement granting Mr.
McCracken an option to purchase 72,500 shares of Common Stock with an exercise
price of $0.30 per share. The shares subject to the option vest over Mr.
McCracken's four-year period of service measured from the option grant date.
 
     In March 1997, the Company and Ms. Eastham entered into an agreement
whereby she is employed as Vice President, Finance and Administration and Chief
Financial Officer. Pursuant to her agreement, Ms. Eastham (i) was to receive an
annual base salary of $186,000 (her current salary is $201,810), which would be
reviewed annually by the Chief Executive Officer and Board of Directors, and
(ii) would be eligible for a bonus of up to 20% of her annual base salary to be
awarded at the discretion of the Board of Directors. In the event the Company
terminates Ms. Eastham's employment without "cause" within two years after her
date of hire, Ms. Eastham will be entitled to receive an aggregate severance
benefit of her base salary and benefits for six months, unless she obtains
full-time employment prior to the end of that six-month period. Simultaneous
with the execution of Ms. Eastham's employment agreement, the Company and Ms.
Eastham entered into a Stock Option Agreement granting her an option to purchase
87,500 shares of Common Stock with an exercise price of $0.40 per share. The
shares subject to the option vest over her four-year period of service with the
Company measured from the grant date.
 
     In connection with an acquisition of the Company by merger or asset sale,
each outstanding option held by individuals in the Company's employ or service,
including the Chief Executive Officer and the other Named Executive Officers,
under the 1997 Stock Incentive Plan will automatically accelerate in full,
except to the extent such options are to be assumed by the successor
corporation. In addition, the Compensation Committee as Plan Administrator has
provided for the accelerated vesting of the shares of Common Stock subject to
outstanding options, or any unvested shares of Common Stock subject to direct
issuances, in connection with the termination of employment following: (i) a
merger or asset sale in which these options are assumed or the repurchase rights
applicable to those shares are assigned or (ii) certain changes in control of
the Company.
 
     The following Board Compensation Committee Report on Executive Compensation
and the Performance Graph on page 20 should not be considered to be part of this
proxy statement and any current or future cross references to this proxy
statement in filings with the SEC under either the Securities Act or the
Securities Exchange Act shall include the report or the graph reproduced below.
 
         BOARD COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION
 
     The Compensation Committee presents this report regarding compensation for
the Company's executive officers and the Chief Executive Officer of the Company.
 
GENERAL COMPENSATION POLICY
 
     The Company's primary objective is to maximize the value of the Company's
shares over time. Accomplishing this objective requires achieving specific
Company milestones and developing and ultimately
                                       17
<PAGE>   21
 
marketing superior technologies that accelerate the discovery process. The
overall goal of the Compensation Committee is to develop compensation practices
that will allow the Company to attract and retain the people needed to achieve
the Company's objectives.
 
     The Company compensates its executive officers with a combination of salary
and incentives designed to focus and balance their efforts on maximizing both
the near-term and long-term financial performance of the Company. In addition,
the Company's compensation structure rewards individual performance that
furthers Company goals. Elements of each officer's compensation include the
following:
 
     - Base Salary
 
     - Annual Incentives
 
     - Long-term Incentives
 
     - Benefits
 
     Each officer's compensation package is designed to provide an appropriately
weighted mix of these elements which cumulatively provides a level of
compensation roughly equivalent to that paid by companies of similar size and
complexity in similar industries.
 
     Base Salary. Base salary and increases in base salary are determined by
individual performance and the salary levels in effect for companies of similar
size and complexity in similar industries. The Compensation Committee attempts
to keep the base salaries of the Company's officers at a level broadly in line
with the median of the salaries of officers in comparative companies. The
Compensation Committee also evaluates individual experience and performance and
specific issues particular to the Company, such as success in raising capital,
creation of stockholder value and achievement of specific Company milestones.
 
     Annual Incentives. Annual Incentives are paid under an incentive
compensation program. Bonus awards are set at a level competitive among peer
group companies and early-stage high growth technology companies. Potential cash
incentive compensation paid under this plan is set as a significant percentage
of each officers' base salary. All of the incentive compensation is directly
tied to performance and is at risk. Each officer earns incentive compensation
based upon a mix of Company performance and personal performance. Company
performance is measured by achievement of specific Company milestones.
Compensation for personal performance under this plan is awarded by the
Compensation Committee based upon both an objective and subjective evaluation of
the performance of each officer. No incentive compensation is paid for Company
performance or personal performance unless specific Company and individual goals
are achieved during the fiscal year. In 1998, incentive compensation earned by
executive officers averaged 20% of base salary.
 
     Long-Term Incentives. Long-term incentive compensation in the form of stock
options is expected to be the largest element of total compensation over time.
Grants of stock options are designed to align the long-term interests of each
officer with the long-term interests of the Company and its stockholders. Stock
options provide each officer with a significant incentive to manage the Company
from the perspective of an owner with an equity stake in the business. The size
of the option grant to each officer is based on the officer's current and
expected future contributions to the business and vesting position. Awards of
stock options are designed to have an expected aggregate exercise value over
time equal to a multiple of salary which will create a significant opportunity
for stock ownership, motivation to remain with the Company and incentive to
increase stockholder value.
 
     Benefits. Benefits offered to the Company's officers are substantially the
same as those offered to all the Company's regular employees and are consistent
with industry practice.
 
                                       18
<PAGE>   22
 
CEO COMPENSATION
 
     In setting compensation payable to the Company's Chief Executive Officer,
Dr. Anido, we have sought to be competitive with companies of similar size and
complexity in similar industries. Dr. Anido's incentive compensation is
dependent upon the Company's performance and our evaluation of his personal
contribution to the Company's performance. No incentive compensation is paid to
Dr. Anido unless progress is made toward specific Company goals or these goals
are achieved during the fiscal year. In 1998, incentive compensation earned by
Dr. Anido was approximately 22% of base salary.
 
     We conclude our report with the acknowledgement that no member of the
Compensation Committee is a current officer or employee of CombiChem or any of
its subsidiaries.
 
     Submitted by the Compensation Committee of the Company's Board of
Directors.
 
                             COMPENSATION COMMITTEE
 
                                 ARTHUR REIDEL
                                 WILLIAM SCOTT
 
                                       19
<PAGE>   23
 
PERFORMANCE GRAPH
 
     The following graph compares total stockholder returns since the Company
became a reporting company under the Exchange Act to the Nasdaq Composite Index
for the Nasdaq Stock Market and the Nasdaq Biotech Index. The total return for
each of the Company's Common Stock, the Nasdaq Composite Index and the Nasdaq
Biotech Index assumes the reinvestment of dividends, although dividends have not
been declared on the Company's Common Stock. The Nasdaq Composite Index tracks
the aggregate price performance of equity securities traded on the Nasdaq. The
Nasdaq Biotech Index tracks approximately 25 domestic stocks in the
biotechnology sector; companies comprising the Nasdaq Biotech Index are
available upon written request to Investor Relations at the Company's executive
offices. The stockholder return shown on the graph below is not necessarily
indicative of future performance and the Company will not make or endorse any
predictions as to future stockholder returns.
 
<TABLE>
<CAPTION>
                                                                                 NASDAQ BIOTECH             NASDAQ COMPOSITE
                                                     COMBICHEM, INC.                  INDEX                       INDEX
                                                     ---------------             --------------             ----------------
<S>                                             <C>                         <C>                         <C>
'5/8/98'                                                   100                         100                         100
'6/30/98'                                                   87                          94                         102
'9/30/98'                                                   50                          95                          91
'12/31/98'                                                  54                         118                         130
'3/31/99'                                                   47                         132                         180
</TABLE>
 
                                       20
<PAGE>   24
 
                              CERTAIN TRANSACTIONS
 
     In May 1998, the Company sold 250,000 shares of its Common Stock to Elan
International Services Ltd. in connection with the Company's initial public
offering.
 
     In February 1997 as incentive for employment, and in June 1997 under an
employee loan program provided for the exercise of options, the Company made
loans in the amounts of $96,000 and $23,044, respectively, to Dr. Anido, the
President, Chief Executive Officer and a Director of the Company, for an
aggregate indebtedness as of March 31, 1999 of $63,822, which includes accrued
interest. Each loan is secured by shares of Common Stock held by Dr. Anido. The
loan for $96,000 is represented by a promissory note which is due and payable on
the earlier of February 23, 2002, the expiration of the 60-day period following
the date Dr. Anido ceases to remain in the service of CombiChem, or the date
that CombiChem completes the consummation of any corporate transaction, as
defined in the promissory note agreement. This loan bears no interest. In
December 1998, the Compensation Committee of the Board of Directors forgave
$48,000 of this loan. The loan for $23,044 is represented by a promissory note
which is due and payable in three annual installments and is due in full upon
the third anniversary of the loan. This loan bears an interest rate of 6.14%.
The largest amount of indebtedness outstanding since the beginning of the last
fiscal year was $119,044.
 
     In September 1995 as incentive for employment, and in June 1997 under an
employee loan program provided for the exercise of options, the Company made
loans in the amounts of $150,000 and $30,375, respectively, to Dr. Myers, the
Vice President, Chief Scientific Officer, Chief Operating Officer and a Director
of the Company, for an aggregate indebtedness as of March 31, 1999 of $201,997,
which includes accrued interest. Each loan is secured by shares of Common Stock
held by Dr. Myers. The loan for $150,000 is represented by a promissory note
which is due and payable on the earlier of April 30, 2000 or the occurrence of
certain events, such as the expiration of the 30-day period following the date
Dr. Myers ceases to remain in the employment of CombiChem. This loan bears an
interest rate equal to the applicable minimum Federal rate on the date of the
loan. The loan for $30,375 is represented by a promissory note that is due and
payable in three annual installments and is due in full upon the third
anniversary of the loan. This loan bears an interest rate of 6.14%. The largest
amount of indebtedness outstanding since the beginning of the last fiscal year
was $202,126.
 
     For information regarding employment agreements with Named Executive
Officers, see "Executive Compensation and Other Information."
 
     All of the Company's officers are employed by the Company at will. The
Company has entered into indemnification agreements with each of its directors
and executive officers.
 
     The Company expects that all future transactions between the Company and
its officers, directors and principal stockholders and their affiliates will be
approved in accordance with the Delaware General Corporation Law by a majority
of the Board, as well as by a majority of the independent and disinterested
directors of the Board, and will be on terms no less favorable to the Company
than could be obtained from unaffiliated third parties.
 
            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
     Section 16(a) of the Exchange Act requires the Company's officers and
directors, and persons who own more than 10% of a registered class of the
Company's equity securities, to file reports of ownership and changes in
ownership with the SEC and the Nasdaq National Market System. Officers,
directors and greater than 10% beneficial owners are required by SEC regulations
to furnish the Company with copies of all Section 16(a) forms they file.
 
     Based solely on review of the copies of such forms furnished to the
Company, or written representations from certain reporting persons that no Forms
5 were required, the Company believes that, during the 1998 fiscal year, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than 10% beneficial owners were satisfied.
 
                                       21
<PAGE>   25
 
                 STOCKHOLDER PROPOSALS FOR 2000 PROXY STATEMENT
 
     Proposals of stockholders of the Company that are intended to be presented
by such stockholders at the Company's 2000 Annual Meeting must be received no
later than December 8, 2000, in order that they may be included in the proxy
statement and form of proxy relating to that meeting.
 
     In addition, the proxy solicited by the Board of Directors for the year
2000 Annual Meeting of Stockholders will confer discretionary authority to vote
on any stockholder proposal presented at that meeting, unless the Company
receives notice of such proposal not later than January 7, 2000.
 
                                 ANNUAL REPORT
 
     A copy of the Annual Report of the Company for the 1998 fiscal year has
been mailed concurrently with this Proxy Statement to all stockholders entitled
to notice of and to vote at the Annual Meeting. The Annual Report is not
incorporated into this Proxy Statement and is not considered proxy solicitation
material.
 
                                   FORM 10-K
 
     The Company filed an Annual Report on Form 10-K with the Securities and
Exchange Commission on or about March 31, 1999. Stockholders may obtain a copy
of this report, without charge, by writing to the Vice President, Finance and
Administration and Chief Financial Officer of the Company, at the Company's
principal executive offices located at 9050 Camino Santa Fe, San Diego,
California, 92121
 
                                 OTHER MATTERS
 
     The Board of Directors is not aware of any matter to be presented for
action at the meeting other than the matters set forth in this Proxy Statement.
Should any other matter requiring a vote of the stockholders arise, the persons
named as proxies on the enclosed proxy card will vote the shares represented
thereby in accordance with their best judgment in the interest of the Company.
Discretionary authority with respect to such other matters is granted by the
execution of the enclosed proxy card.
 
                                          By Order of the Board of Directors
                                          /s/ FAYE H. RUSSELL
 
Dated: April 6, 1999                      Faye H. Russell
                                          Secretary
 
                                       22
<PAGE>   26
                                 COMBICHEM, INC.
                            1997 STOCK INCENTIVE PLAN


                                   ARTICLE ONE

                               GENERAL PROVISIONS


I.   PURPOSE OF THE PLAN

     This 1997 Stock Incentive Plan is intended to promote the interests of
CombiChem, Inc., a Delaware corporation, by providing eligible persons with the
opportunity to acquire a proprietary interest, or otherwise increase their
proprietary interest, in the Corporation as an incentive for them to remain in
the service of the Corporation.

     Capitalized terms shall have the meanings assigned to such terms in the
attached Appendix.

II.  STRUCTURE OF THE PLAN

     A.   The Plan shall be divided into five separate equity programs:

          -    the Discretionary Option Grant Program under which eligible
               persons may, at the discretion of the Plan Administrator, be
               granted options to purchase shares of Common Stock,

          -    the Salary Investment Option Grant Program under which eligible
               employees may elect to have a portion of their base salary
               invested each year in special option grants,

          -    the Stock Issuance Program under which eligible persons may, at
the discretion of the Plan Administrator, be issued shares of Common Stock
directly, either through the immediate purchase of such shares or as a bonus for
services rendered the Corporation (or any Parent or Subsidiary),

          -    the Automatic Option Grant Program under which eligible
non-employee Board members shall automatically receive option grants at periodic
intervals to purchase shares of Common Stock, and

          -    the Director Fee Option Grant Program under which non-employee
Board members may elect to have all or any portion of their annual retainer fee
otherwise payable in cash applied to a special option grant.

     B.   The provisions of Articles One and Seven shall apply to all equity
programs under the Plan and shall govern the interests of all persons under the
Plan.

<PAGE>   27

III. ADMINISTRATION OF THE PLAN

     A.   The Primary Committee shall have sole and exclusive authority to
administer the Discretionary Option Grant and Stock Issuance Programs with
respect to Section 16 Insiders. Administration of the Discretionary Option Grant
and Stock Issuance Programs with respect to all other persons eligible to
participate in those programs may, at the Board's discretion, be vested in the
Primary Committee or a Secondary Committee, or the Board may retain the power to
administer those programs with respect to all such persons.

     B.   Members of the Primary Committee or any Secondary Committee shall
serve for such period of time as the Board may determine and may be removed by
the Board at any time. The Board may also at any time terminate the functions of
any Secondary Committee and reassume all powers and authority previously
delegated to such committee.

     C.   Each Plan Administrator shall, within the scope of its administrative
functions under the Plan, have full power and authority (subject to the
provisions of the Plan) to establish such rules and regulations as it may deem
appropriate for proper administration of the Discretionary Option Grant and
Stock Issuance Programs and to make such determinations under, and issue such
interpretations of, the provisions of such programs and any outstanding options
or stock issuances thereunder as it may deem necessary or advisable. Decisions
of the Plan Administrator within the scope of its administrative functions under
the Plan shall be final and binding on all parties who have an interest in the
Discretionary Option Grant and Stock Issuance Programs under its jurisdiction or
any option or stock issuance thereunder.

     D.   The Primary Committee shall have the sole and exclusive authority to
determine which Section 16 Insiders and other highly compensated Employees shall
be eligible for participation in the Salary Investment Option Grant Program for
one or more calendar years. However, all option grants under the Salary
Investment Option Grant Program shall be made in accordance with the express
terms of that program, and the Primary Committee shall not exercise any
discretionary functions with respect to the option grants made under that
program.

     E.   Service on the Primary Committee or the Secondary Committee shall
constitute service as a Board member, and members of each such committee shall
accordingly be entitled to full indemnification and reimbursement as Board
members for their service on such committee. No member of the Primary Committee
or the Secondary Committee shall be liable for any act or omission made in good
faith with respect to the Plan or any option grants or stock issuances under the
Plan.

     F.   Administration of the Automatic Option Grant and Director Fee Option
Grant Programs shall be self-executing in accordance with the terms of those
programs, and no Plan Administrator shall exercise any discretionary functions
with respect to any option grants or stock issuances made under those programs.

IV.  ELIGIBILITY

     A.   The persons eligible to participate in the Discretionary Option Grant
and Stock Issuance Programs are as follows:

<PAGE>   28

          (i)  Employees,

          (ii) non-employee members of the Board or the board of directors of
     any Parent or Subsidiary, and

          (iii) consultants and other independent advisors who provide services
     to the Corporation (or any Parent or Subsidiary).

     B.   Only Employees who are Section 16 Insiders or other highly compensated
individuals shall be eligible to participate in the Salary Investment Option
Grant Program.

     C.   Each Plan Administrator shall, within the scope of its administrative
jurisdiction under the Plan, have full authority to determine, (i) with respect
to the option grants under the Discretionary Option Grant Program, which
eligible persons are to receive option grants, the time or times when such
option grants are to be made, the number of shares to be covered by each such
grant, the status of the granted option as either an Incentive Option or a
Non-Statutory Option, the time or times when each option is to become
exercisable, the vesting schedule (if any) applicable to the option shares and
the maximum term for which the option is to remain outstanding and (ii) with
respect to stock issuances under the Stock Issuance Program, which eligible
persons are to receive stock issuances, the time or times when such issuances
are to be made, the number of shares to be issued to each Participant, the
vesting schedule (if any) applicable to the issued shares and the consideration
for such shares.

     D.   The Plan Administrator shall have the absolute discretion either to
grant options in accordance with the Discretionary Option Grant Program or to
effect stock issuances in accordance with the Stock Issuance Program.

     E.   The individuals who shall be eligible to participate in the Automatic
Option Grant Program shall be limited to (i) those individuals serving as
non-employee Board members on the Underwriting Date who have not previously
received a stock option grant from the Corporation, (ii) those individuals who
first become non-employee Board members after the Underwriting Date, whether
through appointment by the Board or election by the Corporation's stockholders,
and (iii) those individuals who continue to serve as non-employee Board members
at one or more Annual Stockholders Meetings held after the Underwriting Date. A
non-employee Board member who has previously been in the employ of the
Corporation (or any Parent or Subsidiary) shall not be eligible to receive an
option grant under the Automatic Option Grant Program at the time he or she
first becomes a non-employee Board member, but shall be eligible to receive
periodic option grants under the Automatic Option Grant Program while he or she
continues to serve as a non-employee Board member.

     F.   All non-employee Board members shall be eligible to participate in the
Director Fee Option Grant Program.

V.   STOCK SUBJECT TO THE PLAN

     A.   The stock issuable under the Plan shall be shares of authorized but
unissued or reacquired Common Stock, including shares repurchased by the
Corporation on the open market. The maximum number of shares of Common Stock
initially reserved for issuance 

<PAGE>   29

over the term of the Plan shall not exceed 2,072,170 shares of Common Stock.
Such share reserve includes an increase of 1,000,000 shares authorized by the
Board on March 24, 1999, subject to stockholder approval at the 1999 Annual
Meeting. To the extent any unvested shares of Common Stock outstanding under the
Predecessor Plan as of the Plan Effective Time are subsequently repurchased by
the Corporation, at the option exercise price paid per share, in connection with
the holder's termination of service prior to vesting in the shares, those
repurchased shares shall be added to the reserve of Common Stock available for
issuance under the Plan.

     B.   No one person participating in the Plan may receive options,
separately exercisable stock appreciation rights and direct stock issuances for
more than 500,000 shares of Common Stock in the aggregate per calendar year,
beginning with the 1997 calendar year.

     C.   Shares of Common Stock subject to outstanding options (including
options incorporated into this Plan from the Predecessor Plan) shall be
available for subsequent issuance under the Plan to the extent (i) those options
expire or terminate for any reason prior to exercise in full or (ii) the options
are cancelled in accordance with the cancellation-regrant provisions of Article
Two. Unvested shares issued under the Plan and subsequently cancelled or
repurchased by the Corporation (including unvested shares issued under the
Predecessor Plan and repurchased by the Corporation at or after the Plan
Effective Time), at the original issue price paid per share, pursuant to the
Corporation's repurchase rights under the Plan shall be added back to the number
of shares of Common Stock reserved for issuance under the Plan and shall
accordingly be available for reissuance through one or more subsequent option
grants or direct stock issuances under the Plan. However, should the exercise
price of an option under the Plan be paid with shares of Common Stock or should
shares of Common Stock otherwise issuable under the Plan be withheld by the
Corporation in satisfaction of the withholding taxes incurred in connection with
the exercise of an option or the vesting of a stock issuance under the Plan,
then the number of shares of Common Stock available for issuance under the Plan
shall be reduced by the gross number of shares for which the option is exercised
or which vest under the stock issuance, and not by the net number of shares of
Common Stock issued to the holder of such option or stock issuance. Shares of
Common Stock underlying one or more stock appreciation rights exercised under
Section IV of Article Two of the Plan shall NOT be available for subsequent
issuance under the Plan.

     D.   If any change is made to the Common Stock by reason of any stock
split, stock dividend, recapitalization, combination of shares, exchange of
shares or other change affecting the outstanding Common Stock as a class without
the Corporation's receipt of consideration, appropriate adjustments shall be
made to (i) the maximum number and/or class of securities issuable under the
Plan, (ii) the number and/or class of securities for which any one person may be
granted stock options, separately exercisable stock appreciation rights and
direct stock issuances under the Plan per calendar year, (iii) the number and/or
class of securities for which grants are subsequently to be made under the
Automatic Option Grant Program to new and continuing non-employee Board members,
(iv) the number and/or class of securities and the exercise price per share in
effect under each outstanding option under the Plan and (v) the number and/or
class of securities and price per share in effect under each outstanding option
incorporated into this Plan from the Predecessor Plan. Such adjustments to the
outstanding options are to be effected in a manner which shall preclude the
enlargement or dilution of rights 

<PAGE>   30

and benefits under such options. The adjustments determined by the Plan
Administrator shall be final, binding and conclusive.


                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM


I.   OPTION TERMS

     Each option shall be evidenced by one or more documents in the form
approved by the Plan Administrator; provided, however, that each such document
shall comply with the terms specified below. Each document evidencing an
Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

     A.   EXERCISE PRICE.

          1.   The exercise price per share shall be fixed by the Plan
Administrator but shall not be less than one hundred percent (100%) of the Fair
Market Value per share of Common Stock on the option grant date.

          2.   The exercise price shall become immediately due upon exercise of
the option and shall, subject to the provisions of Section I of Article Six and
the documents evidencing the option, be payable in one or more of the forms
specified below:

               (i)  cash or check made payable to the Corporation,

               (ii) shares of Common Stock held for the requisite period
     necessary to avoid a charge to the Corporation's earnings for financial
     reporting purposes and valued at Fair Market Value on the Exercise Date, or

               (iii) to the extent the option is exercised for vested shares,
     through a special sale and remittance procedure pursuant to which the
     Optionee shall concurrently provide irrevocable instructions to (a) a
     Corporation-designated brokerage firm to effect the immediate sale of the
     purchased shares and remit to the Corporation, out of the sale proceeds
     available on the settlement date, sufficient funds to cover the aggregate
     exercise price payable for the purchased shares plus all applicable
     Federal, state and local income and employment taxes required to be
     withheld by the Corporation by reason of such exercise and (b) the
     Corporation to deliver the certificates for the purchased shares directly
     to such brokerage firm in order to complete the sale.

          Except to the extent such sale and remittance procedure is utilized,
payment of the exercise price for the purchased shares must be made on the
Exercise Date.

     B.   EXERCISE AND TERM OF OPTIONS. Each option shall be exercisable at such
time or times, during such period and for such number of shares as shall be
determined by the 

<PAGE>   31

Plan Administrator and set forth in the documents evidencing the option.
However, no option shall have a term in excess of ten (10) years measured from
the option grant date.

     C.   EFFECT OF TERMINATION OF SERVICE.

          1.   The following provisions shall govern the exercise of any options
held by the Optionee at the time of cessation of Service or death:

               (i)  Any option outstanding at the time of the Optionee's
     cessation of Service for any reason shall remain exercisable for such
     period of time thereafter as shall be determined by the Plan Administrator
     and set forth in the documents evidencing the option, but no such option
     shall be exercisable after the expiration of the option term.

               (ii) Any option exercisable in whole or in part by the Optionee
     at the time of death may be subsequently exercised by the personal
     representative of the Optionee's estate or by the person or persons to whom
     the option is transferred pursuant to the Optionee's will or in accordance
     with the laws of descent and distribution.

               (iii) Should the Optionee's Service be terminated for Misconduct,
     then all outstanding options held by the Optionee shall terminate
     immediately and cease to be outstanding.

               (iv) During the applicable post-Service exercise period, the
     option may not be exercised in the aggregate for more than the number of
     vested shares for which the option is exercisable on the date of the
     Optionee's cessation of Service. Upon the expiration of the applicable
     exercise period or (if earlier) upon the expiration of the option term, the
     option shall terminate and cease to be outstanding for any vested shares
     for which the option has not been exercised. However, the option shall,
     immediately upon the Optionee's cessation of Service, terminate and cease
     to be outstanding to the extent the option is not otherwise at that time
     exercisable for vested shares.

          2.   The Plan Administrator shall have complete discretion,
exercisable either at the time an option is granted or at any time while the
option remains outstanding, to:

               (i)  extend the period of time for which the option is to remain
     exercisable following the Optionee's cessation of Service from the limited
     exercise period otherwise in effect for that option to such greater period
     of time as the Plan Administrator shall deem appropriate, but in no event
     beyond the expiration of the option term, and/or

               (ii) permit the option to be exercised, during the applicable
     post-Service exercise period, not only with respect to the number of vested
     shares of Common Stock for which such option is exercisable at the time of
     the Optionee's cessation of Service but also with respect to one or more

<PAGE>   32

     additional installments in which the Optionee would have vested had the
     Optionee continued in Service.

     D.   STOCKHOLDER RIGHTS. The holder of an option shall have no stockholder
rights with respect to the shares subject to the option until such person shall
have exercised the option, paid the exercise price and become a holder of record
of the purchased shares.

     E.   REPURCHASE RIGHTS. The Plan Administrator shall have the discretion to
grant options which are exercisable for unvested shares of Common Stock. Should
the Optionee cease Service while holding such unvested shares, the Corporation
shall have the right to repurchase, at the exercise price paid per share, any or
all of those unvested shares. The terms upon which such repurchase right shall
be exercisable (including the period and procedure for exercise and the
appropriate vesting schedule for the purchased shares) shall be established by
the Plan Administrator and set forth in the document evidencing such repurchase
right.

     F.   LIMITED TRANSFERABILITY OF OPTIONS. During the lifetime of the
Optionee, Incentive Options shall be exercisable only by the Optionee and shall
not be assignable or transferable other than by will or by the laws of descent
and distribution following the Optionee's death. Non-Statutory Options shall be
subject to the same restrictions, except that a Non-Statutory Option may, in
connection with the Optionee's estate plan, be assigned in whole or in part
during the Optionee's lifetime to one or more members of the Optionee's
immediate family or to a trust established exclusively for one or more such
family members. The assigned portion may only be exercised by the person or
persons who acquire a proprietary interest in the option pursuant to the
assignment. The terms applicable to the assigned portion shall be the same as
those in effect for the option immediately prior to such assignment and shall be
set forth in such documents issued to the assignee as the Plan Administrator may
deem appropriate.

II.  INCENTIVE OPTIONS

     The terms specified below shall be applicable to all Incentive Options.
Except as modified by the provisions of this Section II, all the provisions of
Articles One, Two and Seven shall be applicable to Incentive Options. Options
which are specifically designated as Non-Statutory Options when issued under the
Plan shall not be subject to the terms of this Section II.

     A.   ELIGIBILITY. Incentive Options may only be granted to Employees.

     B.   EXERCISE PRICE. The exercise price per share shall not be less than
one hundred percent (100%) of the Fair Market Value per share of Common Stock on
the option grant date.

     C.   DOLLAR LIMITATION. The aggregate Fair Market Value of the shares of
Common Stock (determined as of the respective date or dates of grant) for which
one or more options granted to any Employee under the Plan (or any other option
plan of the Corporation or any Parent or Subsidiary) may for the first time
become exercisable as Incentive Options during any one calendar year shall not
exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the
Employee holds two (2) or more such options which become exercisable for the
first time in the same calendar year, the foregoing limitation on the
exercisability of such options as Incentive Options shall be applied on the
basis of the order in which such options are granted.

<PAGE>   33

     D.   10% STOCKHOLDER. If any Employee to whom an Incentive Option is
granted is a 10% Stockholder, then the exercise price per share shall not be
less than one hundred ten percent (110%) of the Fair Market Value per share of
Common Stock on the option grant date, and the option term shall not exceed five
(5) years measured from the option grant date.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL

     A.   In the event of any Corporate Transaction, each outstanding option
shall automatically accelerate so that each such option shall, immediately prior
to the effective date of the Corporate Transaction, become fully exercisable
with respect to the total number of shares of Common Stock at the time subject
to such option and may be exercised for any or all of those shares as fully
vested shares of Common Stock. However, an outstanding option shall NOT become
exercisable on such an accelerated basis if and to the extent: (i) such option
is, in connection with the Corporate Transaction, to be assumed by the successor
corporation (or parent thereof) or (ii) such option is to be replaced with a
cash incentive program of the successor corporation which preserves the spread
existing at the time of the Corporate Transaction on any shares for which the
option is not otherwise at that time exercisable and provides for subsequent
payout in accordance with the same exercise/vesting schedule applicable to those
option shares or (iii) the acceleration of such option is subject to other
limitations imposed by the Plan Administrator at the time of the option grant.

     B.   All outstanding repurchase rights shall automatically terminate, and
the shares of Common Stock subject to those terminated rights shall immediately
vest in full, in the event of any Corporate Transaction, except to the extent:
(i) those repurchase rights are to be assigned to the successor corporation (or
parent thereof) in connection with such Corporate Transaction or (ii) such
accelerated vesting is precluded by other limitations imposed by the Plan
Administrator at the time the repurchase right is issued.

     C.   Immediately following the consummation of the Corporate Transaction,
all outstanding options shall terminate and cease to be outstanding, except to
the extent assumed by the successor corporation (or parent thereof).

     D.   Each option which is assumed in connection with a Corporate
Transaction shall be appropriately adjusted, immediately after such Corporate
Transaction, to apply to the number and class of securities which would have
been issuable to the Optionee in consummation of such Corporate Transaction had
the option been exercised immediately prior to such Corporate Transaction.
Appropriate adjustments to reflect such Corporate Transaction shall also be made
to (i) the exercise price payable per share under each outstanding option,
provided the aggregate exercise price payable for such securities shall remain
the same, (ii) the maximum number and/or class of securities available for
issuance over the remaining term of the Plan and (iii) the maximum number and/or
class of securities for which any one person may be granted stock options,
separately exercisable stock appreciation rights and direct stock issuances
under the Plan per calendar year.

     E.   The Plan Administrator shall have the discretionary authority to
provide for the automatic acceleration of one or more outstanding options under
the Discretionary Option Grant Program upon the occurrence of a Corporate
Transaction, whether or not those options are 

<PAGE>   34

to be assumed in the Corporate Transaction, so that each such option shall,
immediately prior to the effect date of such Corporate Transaction, become fully
exercisable with respect to the total number of shares of Common Stock at the
time subject to that option and may be exercised for any or all of those shares
as fully vested shares of Common Stock. In addition, the Plan Administrator
shall have the discretionary authority to structure one or more of the
Corporation's repurchase rights under the Discretionary Option Grant Program so
that those rights shall not be assignable in connection with such Corporate
Transaction and shall accordingly terminate upon the consummation of such
Corporate Transaction, and the shares subject to those terminated rights shall
thereupon vest in full.

     F.   The Plan Administrator shall have full power and authority,
exercisable either at the time the option is granted or at any time while the
option remains outstanding, to provide for the automatic acceleration of one or
more outstanding options under the Discretionary Option Grant Program in the
event the Optionee's Service is subsequently terminated by reason of an
Involuntary Termination within a designated period (not to exceed eighteen (18)
months) following the effective date of any Corporate Transaction in which those
options are assumed and do not otherwise accelerate. Any options so accelerated
shall remain exercisable for fully vested shares until the earlier of (i) the
expiration of the option term or (ii) the expiration of the one (1) year period
measured from the effective date of the Involuntary Termination. In addition,
the Plan Administrator may provide that one or more of the Corporation's
outstanding repurchase rights with respect to shares held by the Optionee at the
time of such Involuntary Termination shall immediately terminate, and the shares
subject to those terminated repurchase rights shall accordingly vest in full.

     G.   The Plan Administrator shall have the discretionary authority to
provide for the automatic acceleration of one or more outstanding options under
the Discretionary Option Grant Program upon the occurrence of a Change in
Control so that each such option shall, immediately prior to the effect date of
such Change in Control, become fully exercisable with respect to the total
number of shares of Common Stock at the time subject to that option and may be
exercised for any or all of those shares as fully vested shares of Common Stock.
In addition, the Plan Administrator shall have the discretionary authority to
structure one or more of the Corporation's repurchase rights under the
Discretionary Option Grant Program so that those rights shall terminate
automatically upon the consummation of such Change in Control, and the shares
subject to those terminated rights shall thereupon vest in full. Alternatively,
the Plan Administrator may condition the automatic acceleration of one or more
outstanding options under the Discretionary Option Grant Program and the
termination of one or more of the Corporation's outstanding repurchase rights
under such program upon the subsequent termination of the Optionee's Service by
reason of an Involuntary Termination within a designated period (not to exceed
eighteen (18) months) following the effective date of such Change in Control.
Each option so accelerated shall remain exercisable for fully vested shares
until the earlier of (i) the expiration of the option term or (ii) the
expiration of the one (1) year period measured from the effective date of
Optionee's cessation of Service.

     H.   The portion of any Incentive Option accelerated in connection with a
Corporate Transaction or Change in Control shall remain exercisable as an
Incentive Option only to the extent the applicable One Hundred Thousand Dollar
($100,000) limitation is not exceeded. To the extent such dollar limitation is
exceeded, 

<PAGE>   35

the accelerated portion of such option shall be exercisable as a Nonstatutory
Option under the Federal tax laws.

     I.   The outstanding options shall in no way affect the right of the
Corporation to adjust, reclassify, reorganize or otherwise change its capital or
business structure or to merge, consolidate, dissolve, liquidate or sell or
transfer all or any part of its business or assets.

IV.  CANCELLATION AND REGRANT OF OPTIONS

     The Plan Administrator shall have the authority to effect, at any time and
from time to time, with the consent of the affected option holders, the
cancellation of any or all outstanding options under the Discretionary Option
Grant Program (including outstanding options incorporated from the Predecessor
Plan) and to grant in substitution new options covering the same or different
number of shares of Common Stock but with an exercise price per share based on
the Fair Market Value per share of Common Stock on the new grant date.

V.   STOCK APPRECIATION RIGHTS

     A.   The Plan Administrator shall have full power and authority to grant to
selected Optionees tandem stock appreciation rights and/or limited stock
appreciation rights.

     B.   The following terms shall govern the grant and exercise of tandem
stock appreciation rights:

          (i)  One or more Optionees may be granted the right, exercisable upon
     such terms as the Plan Administrator may establish, to elect between the
     exercise of the underlying option for shares of Common Stock and the
     surrender of that option in exchange for a distribution from the
     Corporation in an amount equal to the excess of (a) the Fair Market Value
     (on the option surrender date) of the number of shares in which the
     Optionee is at the time vested under the surrendered option (or surrendered
     portion thereof) over (b) the aggregate exercise price payable for such
     shares.

          (ii) No such option surrender shall be effective unless it is approved
     by the Plan Administrator, either at the time of the actual option
     surrender or at any earlier time. If the surrender is so approved, then the
     distribution to which the Optionee shall be entitled may be made in shares
     of Common Stock valued at Fair Market Value on the option surrender date,
     in cash, or partly in shares and partly in cash, as the Plan Administrator
     shall in its sole discretion deem appropriate.

          (iii) If the surrender of an option is not approved by the Plan
     Administrator, then the Optionee shall retain whatever rights the Optionee
     had under the surrendered option (or surrendered portion thereof) on the
     option surrender date and may exercise such rights at any time prior to the
     later of (a) five (5) business days after the receipt of the rejection
     notice or (b) the last day on which the option is otherwise exercisable in
     accordance with the terms of the 

<PAGE>   36

     documents evidencing such option, but in no event may such rights be
     exercised more than ten (10) years after the option grant date.

     C.   The following terms shall govern the grant and exercise of limited
stock appreciation rights:

          (i)  One or more Section 16 Insiders may be granted limited stock
     appreciation rights with respect to their outstanding options.

          (ii) Upon the occurrence of a Hostile Take-Over, each individual
     holding one or more options with such a limited stock appreciation right
     shall have the unconditional right (exercisable for a thirty (30)-day
     period following such Hostile Take-Over) to surrender each such option to
     the Corporation, to the extent the option is at the time exercisable for
     vested shares of Common Stock. In return for the surrendered option, the
     Optionee shall receive a cash distribution from the Corporation in an
     amount equal to the excess of (A) the Take-Over Price of the shares of
     Common Stock which are at the time vested under each surrendered option (or
     surrendered portion thereof) over (B) the aggregate exercise price payable
     for such shares. Such cash distribution shall be paid within five (5) days
     following the option surrender date.

          (iii) The grant of such limited stock appreciation right shall
     automatically constitute pre-approval by the Plan Administrator of any
     subsequent exercise of that right in accordance with the terms of this
     Paragraph C. Accordingly, no further approval of the Plan Administrator or
     the Board shall be required at the time of the actual option surrender and
     cash distribution.

          (iv) The balance of the option (if any) shall remain outstanding and
     exercisable in accordance with the documents evidencing such option.


                                  ARTICLE THREE

                     SALARY INVESTMENT OPTION GRANT PROGRAM


I.   OPTION GRANTS

     The Primary Committee shall have the sole and exclusive authority to
determine the calendar year or years (if any) for which the Salary Investment
Option Grant Program is to be in effect and to select the Section 16 Insiders
and other highly compensated Employees eligible to participate in the Salary
Investment Option Grant Program for those calendar year or years. Each selected
individual who elects to participate in the Salary Investment Option Grant
Program must, prior to the start of each calendar year of participation, file
with the Plan Administrator (or its designate) an irrevocable authorization
directing the Corporation to reduce his or her base salary for that calendar
year by an amount not less than Ten Thousand Dollars ($10,000.00) nor more than
Fifty Thousand Dollars ($50,000.00). The Primary Committee shall have complete
discretion to determine whether to approve the filed authorization in whole or
in 

<PAGE>   37

part. To the extent the Primary Committee approves the authorization, the
individual who filed that authorization shall automatically be granted an option
under the Salary Investment Grant Program on the first trading day in January of
the calendar year for which the salary reduction is to be in effect.

II.  OPTION TERMS

     Each option shall be a Non-Statutory Option evidenced by one or more
documents in the form approved by the Plan Administrator; provided, however,
that each such document shall comply with the terms specified below.

     A.   EXERCISE PRICE.

          1.   The exercise price per share shall be thirty-three and one-third
percent (33-1/3%) of the Fair Market Value per share of Common Stock on the
option grant date.

          2.   The exercise price shall become immediately due upon exercise of
the option and shall be payable in one or more of the alternative forms
authorized under the Discretionary Option Grant Program. Except to the extent
the sale and remittance procedure specified thereunder is utilized, payment of
the exercise price for the purchased shares must be made on the Exercise Date.

     B.   NUMBER OF OPTION SHARES. The number of shares of Common Stock subject
to the option shall be determined pursuant to the following formula (rounded
down to the nearest whole number):

          X = A divided by (B x 66-2/3%), where

          X is the number of option shares,

          A is the dollar amount of the approved reduction in the Optionee's
     base salary for the calendar year, and

          B is the Fair Market Value per share of Common Stock on the option
     grant date.

     C.   EXERCISE AND TERM OF OPTIONS. The option shall become exercisable in a
series of twelve (12) successive equal monthly installments upon the Optionee's
completion of each calendar month of Service in the calendar year for which the
salary reduction is in effect. Each option shall have a maximum term of ten (10)
years measured from the option grant date.

     D.   EFFECT OF TERMINATION OF SERVICE. Should the Optionee cease Service
for any reason while holding one or more options under this Article Three, then
each such option shall remain exercisable, for any or all of the shares for
which the option is exercisable at the time of such cessation of Service, until
the earlier of (i) the expiration of the ten (10)-year option term or (ii) the
expiration of the three (3)-year period measured from the date of such cessation
of Service. Should the Optionee die while holding one or more options under this
Article Three, then each such option may be exercised, for any or all of the
shares for which the option is 

<PAGE>   38

exercisable at the time of the Optionee's cessation of Service (less any shares
subsequently purchased by Optionee prior to death), by the personal
representative of the Optionee's estate or by the person or persons to whom the
option is transferred pursuant to the Optionee's will or in accordance with the
laws of descent and distribution. Such right of exercise shall lapse, and the
option shall terminate, upon the earlier of (i) the expiration of the ten
(10)-year option term or (ii) the three (3)-year period measured from the date
of the Optionee's cessation of Service. However, the option shall, immediately
upon the Optionee's cessation of Service for any reason, terminate and cease to
remain outstanding with respect to any and all shares of Common Stock for which
the option is not otherwise at that time exercisable.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

     A.   In the event of any Corporate Transaction while the Optionee remains
in Service, each outstanding option held by such Optionee under this Salary
Investment Option Grant Program shall automatically accelerate so that each such
option shall, immediately prior to the effective date of the Corporate
Transaction, become fully exercisable with respect to the total number of shares
of Common Stock at the time subject to such option and may be exercised for any
or all of those shares as fully-vested shares of Common Stock. Each such
outstanding option shall be assumed by the successor corporation (or parent
thereof) in the Corporate Transaction and shall remain exercisable for the
fully-vested shares until the earlier of (i) the expiration of the ten (10)-year
option term or (ii) the expiration of the three (3)-year period measured from
the date of the Optionee's cessation of Service.

     B.   In the event of a Change in Control while the Optionee remains in
Service, each outstanding option held by such Optionee under this Salary
Investment Option Grant Program shall automatically accelerate so that each such
option shall immediately become fully exercisable with respect to the total
number of shares of Common Stock at the time subject to such option and may be
exercised for any or all of those shares as fully-vested shares of Common Stock.
The option shall remain so exercisable until the earlier of (i) the expiration
of the ten (10)-year option term, (ii) the expiration of the three (3)-year
period measured from the date of the Optionee's cessation of Service or (iii)
the surrender of the option in connection with a Hostile Take-Over.

     C.   Upon the occurrence of a Hostile Take-Over, the Optionee shall have a
thirty (30)-day period in which to surrender to the Corporation each outstanding
option granted him or her under the Salary Investment Option Grant Program. The
Optionee shall in return be entitled to a cash distribution from the Corporation
in an amount equal to the excess of (i) the Take-Over Price of the shares of
Common Stock at the time subject to the surrendered option (whether or not the
Optionee is otherwise at the time vested in those shares) over (ii) the
aggregate exercise price payable for such shares. Such cash distribution shall
be paid within five (5) days following the surrender of the option to the
Corporation. The Primary Committee shall, at the time the option with such
limited stock appreciation right is granted under the Salary Investment Option
Grant Program, pre-approve any subsequent exercise of that right in accordance
with the terms of this Paragraph C. Accordingly, no further approval of the
Primary Committee or the Board shall be required at the time of the actual
option surrender and cash distribution.

<PAGE>   39

     D.   The grant of options under the Salary Investment Option Grant Program
shall in no way affect the right of the Corporation to adjust, reclassify,
reorganize or otherwise change its capital or business structure or to merge,
consolidate, dissolve, liquidate or sell or transfer all or any part of its
business or assets.

III. REMAINING TERMS

     The remaining terms of each option granted under the Salary Investment
Option Grant Program shall be the same as the terms in effect for option grants
made under the Discretionary Option Grant Program.


                                  ARTICLE FOUR

                             STOCK ISSUANCE PROGRAM

I.   STOCK ISSUANCE TERMS

     Shares of Common Stock may be issued under the Stock Issuance Program
through direct and immediate issuances without any intervening option grants.
Each such stock issuance shall be evidenced by a Stock Issuance Agreement which
complies with the terms specified below.

     A.   PURCHASE PRICE.

          1.   The purchase price per share shall be fixed by the Plan
Administrator, but shall not be less than one hundred percent (100%) of the Fair
Market Value per share of Common Stock on the issuance date.

          2.   Subject to the provisions of Section I of Article Seven, shares
of Common Stock may be issued under the Stock Issuance Program for any of the
following items of consideration which the Plan Administrator may deem
appropriate in each individual instance:

               (i)  cash or check made payable to the Corporation, or

               (ii) past services rendered to the Corporation (or any Parent or
     Subsidiary).

     B.   VESTING PROVISIONS.

          1.   Shares of Common Stock issued under the Stock Issuance Program
may, in the discretion of the Plan Administrator, be fully and immediately
vested upon issuance or may vest in one or more installments over the
Participant's period of Service or upon attainment of specified performance
objectives. The elements of the vesting schedule applicable to any unvested
shares of Common Stock issued under the Stock Issuance Program, namely:

               (i)  the Service period to be completed by the Participant or the
     performance objectives to be attained,

<PAGE>   40

               (ii) the number of installments in which the shares are to vest,

               (iii) the interval or intervals (if any) which are to lapse
     between installments, and



               (iv) the effect which death, Permanent Disability or other event
     designated by the Plan Administrator is to have upon the vesting schedule,

shall be determined by the Plan Administrator and incorporated into the Stock
Issuance Agreement.

          2.   Any new, substituted or additional securities or other property
(including money paid other than as a regular cash dividend) which the
Participant may have the right to receive with respect to the Participant's
unvested shares of Common Stock by reason of any stock dividend, stock split,
recapitalization, combination of shares, exchange of shares or other change
affecting the outstanding Common Stock as a class without the Corporation's
receipt of consideration shall be issued subject to (i) the same vesting
requirements applicable to the Participant's unvested shares of Common Stock and
(ii) such escrow arrangements as the Plan Administrator shall deem appropriate.

          3.   The Participant shall have full stockholder rights with respect
to any shares of Common Stock issued to the Participant under the Stock Issuance
Program, whether or not the Participant's interest in those shares is vested.
Accordingly, the Participant shall have the right to vote such shares and to
receive any regular cash dividends paid on such shares.

          4.   Should the Participant cease to remain in Service while holding
one or more unvested shares of Common Stock issued under the Stock Issuance
Program or should the performance objectives not be attained with respect to one
or more such unvested shares of Common Stock, then those shares shall be
immediately surrendered to the Corporation for cancellation, and the Participant
shall have no further stockholder rights with respect to those shares. To the
extent the surrendered shares were previously issued to the Participant for
consideration paid in cash or cash equivalent (including the Participant's
purchase-money indebtedness), the Corporation shall repay to the Participant the
cash consideration paid for the surrendered shares and shall cancel the unpaid
principal balance of any outstanding purchase-money note of the Participant
attributable to the surrendered shares.

          5.   The Plan Administrator may in its discretion waive the surrender
and cancellation of one or more unvested shares of Common Stock which would
otherwise occur upon the cessation of the Participant's Service or the
non-attainment of the performance objectives applicable to those shares. Such
waiver shall result in the immediate vesting of the Participant's interest in
the shares of Common Stock as to which the waiver applies. Such 

<PAGE>   41

waiver may be effected at any time, whether before or after the Participant's
cessation of Service or the attainment or non-attainment of the applicable
performance objectives.

II.  CORPORATE TRANSACTION/CHANGE IN CONTROL

          A.   All of the Corporation's outstanding repurchase rights under the
Stock Issuance Program shall terminate automatically, and all the shares of
Common Stock subject to those terminated rights shall immediately vest in full,
in the event of any Corporate Transaction, except to the extent (i) those
repurchase rights are to be assigned to the successor corporation (or parent
thereof) in connection with such Corporate Transaction or (ii) such accelerated
vesting is precluded by other limitations imposed in the Stock Issuance
Agreement.

          B.   The Plan Administrator shall have the discretionary authority,
exercisable either at the time the unvested shares are issued or any time while
the Corporation's repurchase rights remain outstanding under the Stock Issuance
Program, to provide that those rights shall automatically terminate in whole or
in part, and the shares of Common Stock subject to those terminated rights shall
immediately vest, in the event the Participant's Service should subsequently
terminate by reason of an Involuntary Termination within a designated period
(not to exceed eighteen (18) months) following the effective date of any
Corporate Transaction in which those repurchase rights are assigned to the
successor corporation (or parent thereof).

          C.   The Plan Administrator shall have the discretionary authority,
exercisable either at the time the unvested shares are issued or any time while
the Corporation's repurchase rights remain outstanding under the Stock Issuance
Program, to provide that those rights shall automatically terminate in whole or
in part, and the shares of Common Stock subject to those terminated rights shall
immediately vest, in the event the Participant's Service should subsequently
terminate by reason of an Involuntary Termination within a designated period
(not to exceed eighteen (18) months) following the effective date of any Change
in Control.

III. SHARE ESCROW/LEGENDS

     Unvested shares may, in the Plan Administrator's discretion, be held in
escrow by the Corporation until the Participant's interest in such shares vests
or may be issued directly to the Participant with restrictive legends on the
certificates evidencing those unvested shares.


                                  ARTICLE FIVE

                         AUTOMATIC OPTION GRANT PROGRAM

I.   OPTION TERMS

     A.   GRANT DATES. Option grants shall be made on the dates specified below:

          1.   Each individual serving as a non-employee Board member on the
Underwriting Date shall automatically be granted at that time a Non-Statutory
Option to purchase 20,000 shares of Common Stock, provided that individual has
not previously been in the employ of the Corporation or any Parent or Subsidiary
and has not previously received a stock option grant from the Corporation.

<PAGE>   42

          2.   Each individual who is first elected or appointed as a
non-employee Board member at any time after the Underwriting Date shall
automatically be granted, on the date of such initial election or appointment, a
Non-Statutory Option to purchase 20,000 shares of Common Stock, provided that
individual has not previously been in the employ of the Corporation or any
Parent or Subsidiary.

          3.   On the date of each Annual Stockholders Meeting held after the
Underwriting Date, each individual who is to continue to serve as an Eligible
Director, whether or not that individual is standing for re-election to the
Board at that particular Annual Meeting, shall automatically be granted a
Non-Statutory Option to purchase 5,000 shares of Common Stock, provided such
individual has served as a non-employee Board member for at least six (6)
months. There shall be no limit on the number of such 5,000-share option grants
any one Eligible Director may receive over his or her period of Board service,
and non-employee Board members who have previously been in the employ of the
Corporation (or any Parent or Subsidiary) or who have otherwise received a stock
option grant from the Corporation prior to the Underwriting Date shall be
eligible to receive one or more such annual option grants over their period of
continued Board service.

     B.   EXERCISE PRICE.

          1.   The exercise price per share shall be equal to one hundred
percent (100%) of the Fair Market Value per share of Common Stock on the option
grant date.

          2.   The exercise price shall be payable in one or more of the
alternative forms authorized under the Discretionary Option Grant Program.
Except to the extent the sale and remittance procedure specified thereunder is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.

     C.   OPTION TERM. Each option shall have a term of ten (10) years measured
from the option grant date.

     D.   EXERCISE AND VESTING OF OPTIONS. Each option shall be immediately
exercisable for any or all of the option shares. However, any shares purchased
under the option shall be subject to repurchase by the Corporation, at the
exercise price paid per share, upon the Optionee's cessation of Board service
prior to vesting in those shares. Each initial 20,000-share automatic option
grant shall vest, and the Corporation's repurchase right shall lapse, as
follows: (i) twenty-five percent (25%) upon Optionee's completion of one (1)
year of Board service measured from the grant date and (ii) the balance in a
series of thirty-six (36) successive equal monthly installments upon the
Optionee's completion of each additional month of Board service over the
thirty-six (36)-month period measured from the first anniversary of the option
grant date. Each annual 5,000-share automatic option shall vest, and the
Corporation's repurchase right shall lapse, upon the Optionee's completion of
one (1) year of Board service measured from the grant date.

     E.   TERMINATION OF BOARD SERVICE. The following provisions shall govern
the exercise of any options held by the Optionee at the time the Optionee ceases
to serve as a Board member:

<PAGE>   43

          (i)  The Optionee (or, in the event of Optionee's death, the personal
     representative of the Optionee's estate or the person or persons to whom
     the option is transferred pursuant to the Optionee's will or in accordance
     with the laws of descent and distribution) shall have a twelve (12)-month
     period following the date of such cessation of Board service in which to
     exercise each such option.

          (ii) During the twelve (12)-month exercise period, the option may not
     be exercised in the aggregate for more than the number of vested shares of
     Common Stock for which the option is exercisable at the time of the
     Optionee's cessation of Board service.

          (iii) Should the Optionee cease to serve as a Board member by reason
     of death or Permanent Disability, then all shares at the time subject to
     the option shall immediately vest so that such option may, during the
     twelve (12)-month exercise period following such cessation of Board
     service, be exercised for all or any portion of those shares as
     fully-vested shares of Common Stock.

          (iv) In no event shall the option remain exercisable after the
     expiration of the option term. Upon the expiration of the twelve (12)-month
     exercise period or (if earlier) upon the expiration of the option term, the
     option shall terminate and cease to be outstanding for any vested shares
     for which the option has not been exercised. However, the option shall,
     immediately upon the Optionee's cessation of Board service for any reason
     other than death or Permanent Disability, terminate and cease to be
     outstanding to the extent the option is not otherwise at that time
     exercisable for vested shares.

II.  CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

     A.   In the event of any Corporate Transaction, the shares of Common Stock
at the time subject to each outstanding option but not otherwise vested shall
automatically vest in full so that each such option shall, immediately prior to
the effective date of the Corporate Transaction, become fully exercisable for
all of the shares of Common Stock at the time subject to such option and may be
exercised for all or any portion of those shares as fully-vested shares of
Common Stock. Immediately following the consummation of the Corporate
Transaction, each automatic option grant shall terminate and cease to be
outstanding, except to the extent assumed by the successor corporation (or
parent thereof).

     B.   In connection with any Change in Control, the shares of Common Stock
at the time subject to each outstanding option but not otherwise vested shall
automatically vest in full so that each such option shall, immediately prior to
the effective date of the Change in Control, become fully exercisable for all of
the shares of Common Stock at the time subject to such option and may be
exercised for all or any portion of those shares as fully-vested shares of
Common Stock. Each such option shall remain exercisable for such fully-vested
option shares 

<PAGE>   44

until the expiration or sooner termination of the option term or the surrender
of the option in connection with a Hostile Take-Over.

     C.   All outstanding repurchase rights shall automatically terminate, and
the shares of Common Stock subject to those terminated rights shall immediately
vest in full, in the event of any Corporate Transaction or Change in Control.

     D.   Upon the occurrence of a Hostile Take-Over, the Optionee shall have a
thirty (30)-day period in which to surrender to the Corporation each of his or
her outstanding automatic option grants. The Optionee shall in return be
entitled to a cash distribution from the Corporation in an amount equal to the
excess of (i) the Take-Over Price of the shares of Common Stock at the time
subject to each surrendered option (whether or not the Optionee is otherwise at
the time vested in those shares) over (ii) the aggregate exercise price payable
for such shares. Such cash distribution shall be paid within five (5) days
following the surrender of the option to the Corporation. No approval or consent
of the Board or any Plan Administrator shall be required in connection with such
option surrender and cash distribution.

     E.   Each option which is assumed in connection with a Corporate
Transaction shall be appropriately adjusted, immediately after such Corporate
Transaction, to apply to the number and class of securities which would have
been issuable to the Optionee in consummation of such Corporate Transaction had
the option been exercised immediately prior to such Corporate Transaction.
Appropriate adjustments shall also be made to the exercise price payable per
share under each outstanding option, provided the aggregate exercise price
payable for such securities shall remain the same.

     F.   The grant of options under the Automatic Option Grant Program shall in
no way affect the right of the Corporation to adjust, reclassify, reorganize or
otherwise change its capital or business structure or to merge, consolidate,
dissolve, liquidate or sell or transfer all or any part of its business or
assets.

III. REMAINING TERMS

     The remaining terms of each option granted under the Automatic Option Grant
Program shall be the same as the terms in effect for option grants made under
the Discretionary Option Grant Program.


                                   ARTICLE SIX

                        DIRECTOR FEE OPTION GRANT PROGRAM

I.   OPTION GRANTS

     Each non-employee Board member may elect to apply all or any portion of the
annual retainer fee otherwise payable in cash for his or her service on the
Board to the acquisition of a special option grant under this Director Fee
Option Grant Program. Such election must be filed with the Corporation's Chief
Financial Officer prior to first day of the calendar year for which the annual
retainer fee which is the subject of that election is otherwise payable. Each
non-employee Board member who files such a timely election shall automatically

<PAGE>   45

be granted an option under this Director Fee Option Grant Program on the first
trading day in January in the calendar year for which the annual retainer fee
which is the subject of that election would otherwise be payable in cash.

II.  OPTION TERMS

     Each option shall be a Non-Statutory Option governed by the terms and
conditions specified below.

     A.   EXERCISE PRICE.

          1.   The exercise price per share shall be thirty-three and one-third
percent (33-1/3%) of the Fair Market Value per share of Common Stock on the
option grant date.

          2.   The exercise price shall become immediately due upon exercise of
the option and shall be payable in one or more of the alternative forms
authorized under the Discretionary Option Grant Program. Except to the extent
the sale and remittance procedure specified thereunder is utilized, payment of
the exercise price for the purchased shares must be made on the Exercise Date.

     B.   NUMBER OF OPTION SHARES. The number of shares of Common Stock subject
to the option shall be determined pursuant to the following formula (rounded
down to the nearest whole number):

          X = A divided by (B x 66-2/3%), where

          X is the number of option shares,

          A is the portion of the annual retainer fee subject to the
     non-employee Board member's election, and

          B is the Fair Market Value per share of Common Stock on the option
     grant date.

     C.   EXERCISE AND TERM OF OPTIONS. The option shall become exercisable in a
series of twelve (12) equal monthly installments upon the Optionee's completion
of each month of Board service over the twelve (12)-month period measured from
the grant date. Each option shall have a maximum term of ten (10) years measured
from the option grant date.

     D.   TERMINATION OF BOARD SERVICE. Should the Optionee cease Board service
for any reason (other than death or Permanent Disability) while holding one or
more options under this Director Fee Option Grant Program, then each such option
shall remain exercisable, for any or all of the shares for which the option is
exercisable at the time of such cessation of Board service, until the earlier of
(i) the expiration of the ten (10)-year option term or (ii) the expiration of
the three (3)-year period measured from the date of such cessation of Board
service. However, each option held by the Optionee under this Director Fee
Option Grant Program at the time of his or her cessation of Board service shall
immediately terminate and cease to remain 

<PAGE>   46

outstanding with respect to any and all shares of Common Stock for which the
option is not otherwise at that time exercisable.

     E.   DEATH OR PERMANENT DISABILITY. Should the Optionee's service as a
Board member cease by reason of death or Permanent Disability, then each option
held by such Optionee under this Director Fee Option Grant Program shall
immediately become exercisable for all the shares of Common Stock at the time
subject to that option, and the option may be exercised for any or all of those
shares as fully-vested shares until the earlier of (i) the expiration of the ten
(10)-year option term or (ii) the expiration of the three (3)-year period
measured from the date of such cessation of Board service.

     Should the Optionee die after cessation of Board service but while holding
one or more options under this Director Fee Option Grant Program, then each such
option may be exercised, for any or all of the shares for which the option is
exercisable at the time of the Optionee's cessation of Board service (less any
shares subsequently purchased by Optionee prior to death), by the personal
representative of the Optionee's estate or by the person or persons to whom the
option is transferred pursuant to the Optionee's will or in accordance with the
laws of descent and distribution. Such right of exercise shall lapse, and the
option shall terminate, upon the earlier of (i) the expiration of the ten
(10)-year option term or (ii) the three (3)-year period measured from the date
of the Optionee's cessation of Board service.

III. CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

     A.   In the event of any Corporate Transaction while the Optionee remains a
Board member, each outstanding option held by such Optionee under this Director
Fee Option Grant Program shall automatically accelerate so that each such option
shall, immediately prior to the effective date of the Corporate Transaction,
become fully exercisable with respect to the total number of shares of Common
Stock at the time subject to such option and may be exercised for any or all of
those shares as fully-vested shares of Common Stock. Each such outstanding
option shall be assumed by the successor corporation (or parent thereof) in the
Corporate Transaction and shall remain exercisable for the fully-vested shares
until the earlier of (i) the expiration of the ten (10)-year option term or (ii)
the expiration of the three (3)-year period measured from the date of the
Optionee's cessation of Board service.

     B.   In the event of a Change in Control while the Optionee remains in
Service, each outstanding option held by such Optionee under this Director Fee
Option Grant Program shall automatically accelerate so that each such option
shall immediately become fully exercisable with respect to the total number of
shares of Common Stock at the time subject to such option and may be exercised
for any or all of those shares as fully-vested shares of Common Stock. The
option shall remain so exercisable until the earlier or (i) the expiration of
the ten (10)-year option term or (ii) the expiration of the three (3)-year
period measured from the date of the Optionee's cessation of Service.

     C.   Upon the occurrence of a Hostile Take-Over, the Optionee shall have a
thirty (30)-day period in which to surrender to the Corporation each outstanding
option granted him or her under the Director Fee Option Grant Program. The
Optionee shall in return be 

<PAGE>   47

entitled to a cash distribution from the Corporation in an amount equal to the
excess of (i) the Take-Over Price of the shares of Common Stock at the time
subject to each surrendered option (whether or not the Optionee is otherwise at
the time vested in those shares) over (ii) the aggregate exercise price payable
for such shares. Such cash distribution shall be paid within five (5) days
following the surrender of the option to the Corporation. No approval or consent
of the Board or any Plan Administrator shall be required in connection with such
option surrender and cash distribution.

     D.   The grant of options under the Director Fee Option Grant Program shall
in no way affect the right of the Corporation to adjust, reclassify, reorganize
or otherwise change its capital or business structure or to merge, consolidate,
dissolve, liquidate or sell or transfer all or any part of its business or
assets.

IV.  REMAINING TERMS

     The remaining terms of each option granted under this Director Fee Option
Grant Program shall be the same as the terms in effect for option grants made
under the Discretionary Option Grant Program.


                                  ARTICLE SEVEN

                                  MISCELLANEOUS

I.   FINANCING

     The Plan Administrator may permit any Optionee or Participant to pay the
option exercise price under the Discretionary Option Grant Program or the
purchase price of shares issued under the Stock Issuance Program by delivering a
full-recourse, interest bearing promissory note payable in one or more
installments. The terms of any such promissory note (including the interest rate
and the terms of repayment) shall be established by the Plan Administrator in
its sole discretion. In no event may the maximum credit available to the
Optionee or Participant exceed the sum of (i) the aggregate option exercise
price or purchase price payable for the purchased shares plus (ii) any Federal,
state and local income and employment tax liability incurred by the Optionee or
the Participant in connection with the option exercise or share purchase.

II.  TAX WITHHOLDING

     A.   The Corporation's obligation to deliver shares of Common Stock upon
the exercise of options or the issuance or vesting of such shares under the Plan
shall be subject to the satisfaction of all applicable Federal, state and local
income and employment tax withholding requirements.

     B.   The Plan Administrator may, in its discretion, provide any or all
holders of Non-Statutory Options or unvested shares of Common Stock under the
Plan (other than the options granted or the shares issued under the Automatic
Option Grant or Director Fee Option Grant Program) with the right to use shares
of Common Stock in satisfaction of all or part of the Taxes incurred by such
holders in connection with the exercise of their options or the vesting of 

<PAGE>   48

their shares. Such right may be provided to any such holder in either or both of
the following formats:

     Stock Withholding: The election to have the Corporation withhold, from the
shares of Common Stock otherwise issuable upon the exercise of such
Non-Statutory Option or the vesting of such shares, a portion of those shares
with an aggregate Fair Market Value equal to the percentage of the Taxes (not to
exceed one hundred percent (100%)) designated by the holder.

     Stock Delivery: The election to deliver to the Corporation, at the time the
Non-Statutory Option is exercised or the shares vest, one or more shares of
Common Stock previously acquired by such holder (other than in connection with
the option exercise or share vesting triggering the Taxes) with an aggregate
Fair Market Value equal to the percentage of the Taxes (not to exceed one
hundred percent (100%)) designated by the holder.

III. EFFECTIVE DATE AND TERM OF THE PLAN

     A.   The Plan shall become effective immediately at the Plan Effective
Time. However, the Salary Investment Option Grant Program shall not be
implemented until such time as the Primary Committee may deem appropriate.
Options may be granted under the Discretionary Option Grant or Automatic Option
Grant Program at any time at or after the Plan Effective Time. However, no
options granted under the Plan may be exercised, and no shares shall be issued
under the Plan, until the Plan is approved by the Corporation's stockholders. If
such stockholder approval is not obtained within twelve (12) months after the
Plan Effective Time, then all options previously granted under this Plan shall
terminate and cease to be outstanding, and no further options shall be granted
and no shares shall be issued under the Plan.

     B.   The Plan shall serve as the successor to the Predecessor Plan, and no
further option grants or direct stock issuances shall be made under the
Predecessor Plan after the Section 12 Registration Date. All options outstanding
under the Predecessor Plan on the Section 12 Registration Date shall be
incorporated into the Plan at that time and shall be treated as outstanding
options under the Plan. However, each outstanding option so incorporated shall
continue to be governed solely by the terms of the documents evidencing such
option, and no provision of the Plan shall be deemed to affect or otherwise
modify the rights or obligations of the holders of such incorporated options
with respect to their acquisition of shares of Common Stock.

     C.   One or more provisions of the Plan, including (without limitation) the
option/vesting acceleration provisions of Article Two relating to Corporate
Transactions and Changes in Control, may, in the Plan Administrator's
discretion, be extended to one or more options incorporated from the Predecessor
Plan which do not otherwise contain such provisions.

     D.   The Plan shall terminate upon the earliest to occur of (i) October 31,
2007, (ii) the date on which all shares available for issuance under the Plan
shall have been issued as fully-vested shares or (iii) the termination of all
outstanding options in connection with a Corporate Transaction. Should the Plan
terminate on October 31, 2007, then all option grants 

<PAGE>   49

and unvested stock issuances outstanding at that time shall continue to have
force and effect in accordance with the provisions of the documents evidencing
such grants or issuances.

IV.  AMENDMENT OF THE PLAN

     A.   The Board shall have complete and exclusive power and authority to
amend or modify the Plan in any or all respects. However, no such amendment or
modification shall adversely affect the rights and obligations with respect to
stock options or unvested stock issuances at the time outstanding under the Plan
unless the Optionee or the Participant consents to such amendment or
modification. In addition, certain amendments may require stockholder approval
pursuant to applicable laws or regulations.

     B.   Options to purchase shares of Common Stock may be granted under the
Discretionary Option Grant and Salary Investment Option Grant Programs and
shares of Common Stock may be issued under the Stock Issuance Program that are
in each instance in excess of the number of shares then available for issuance
under the Plan, provided any excess shares actually issued under those programs
shall be held in escrow until there is obtained stockholder approval of an
amendment sufficiently increasing the number of shares of Common Stock available
for issuance under the Plan. If such stockholder approval is not obtained within
twelve (12) months after the date the first such excess issuances are made, then
(i) any unexercised options granted on the basis of such excess shares shall
terminate and cease to be outstanding and (ii) the Corporation shall promptly
refund to the Optionees and the Participants the exercise or purchase price paid
for any excess shares issued under the Plan and held in escrow, together with
interest (at the applicable Short Term Federal Rate) for the period the shares
were held in escrow, and such shares shall thereupon be automatically cancelled
and cease to be outstanding.

     C.   On March 24, 1999, the Board amended the Plan to increase the maximum
number of shares of Common Stock authorized for issuance over the term of the
Plan from 1,072,170 shares to 2,072,170 shares. This amendment is subject to
stockholder approval at the 1999 Annual Meeting. Until such stockholder approval
is obtained, any options granted on the basis of the amendment shall not become
exercisable in whole or in part, and those options shall terminate without ever
becoming exercisable for the option shares. All option grants and direct stock
issuances made prior to the amendment shall remain outstanding in accordance
with the terms and conditions of the respective instruments evidencing those
options or issuances, and nothing in this amendment shall be deemed to modify or
in any way affect those outstanding options or issuances.

V.   USE OF PROCEEDS

     Any cash proceeds received by the Corporation from the sale of shares of
Common Stock under the Plan shall be used for general corporate purposes.

VI.  REGULATORY APPROVALS

     A.   The implementation of the Plan, the granting of any stock option under
the Plan and the issuance of any shares of Common Stock (i) upon the exercise of
any granted option or (ii) under the Stock Issuance Program shall be subject to
the Corporation's procurement of all 

<PAGE>   50

approvals and permits required by regulatory authorities having jurisdiction
over the Plan, the stock options granted under it and the shares of Common Stock
issued pursuant to it.

     B.   No shares of Common Stock or other assets shall be issued or delivered
under the Plan unless and until there shall have been compliance with all
applicable requirements of Federal and state securities laws, including the
filing and effectiveness of the Form S-8 registration statement for the shares
of Common Stock issuable under the Plan, and all applicable listing requirements
of any stock exchange (or the Nasdaq National Market, if applicable) on which
Common Stock is then listed for trading.

VII. NO EMPLOYMENT/SERVICE RIGHTS

     Nothing in the Plan shall confer upon the Optionee or the Participant any
right to continue in Service for any period of specific duration or interfere
with or otherwise restrict in any way the rights of the Corporation (or any
Parent or Subsidiary employing or retaining such person) or of the Optionee or
the Participant, which rights are hereby expressly reserved by each, to
terminate such person's Service at any time for any reason, with or without
cause.

<PAGE>   51

                                    APPENDIX


     The following definitions shall be in effect under the Plan:

     A.   AUTOMATIC OPTION GRANT PROGRAM shall mean the automatic option grant
program in effect under the Plan.

     B.   BOARD shall mean the Corporation's Board of Directors.

     C.   CHANGE IN CONTROL shall mean a change in ownership or control of the
Corporation effected through either of the following transactions:

          (i)  the acquisition, directly or indirectly by any person or related
group of persons (other than the Corporation or a person that directly or
indirectly controls, is controlled by, or is under common control with, the
Corporation), of beneficial ownership (within the meaning of Rule 13d-3 of the
1934 Act) of securities possessing more than fifty percent (50%) of the total
combined voting power of the Corporation's outstanding securities pursuant to a
tender or exchange offer made directly to the Corporation's stockholders, or

          (ii) a change in the composition of the Board over a period of
thirty-six (36) consecutive months or less such that a majority of the Board
members ceases, by reason of one or more contested elections for Board
membership, to be comprised of individuals who either (A) have been Board
members continuously since the beginning of such period or (B) have been elected
or nominated for election as Board members during such period by at least a
majority of the Board members described in clause (A) who were still in office
at the time the Board approved such election or nomination.

     D.   CODE shall mean the Internal Revenue Code of 1986, as amended.

     E.   COMMON STOCK shall mean the Corporation's common stock.

     F.   CORPORATE TRANSACTION shall mean either of the following
stockholder-approved transactions to which the Corporation is a party:

          (i)  a merger or consolidation in which securities possessing more
than fifty percent (50%) of the total combined voting power of the Corporation's
outstanding securities are transferred to a person or persons different from the
persons holding those securities immediately prior to such transaction, or

          (ii) the sale, transfer or other disposition of all or substantially
all of the Corporation's assets in complete liquidation or dissolution of the
Corporation.

<PAGE>   52

     G.   CORPORATION shall mean CombiChem, Inc., a Delaware corporation, and
its successors.

     H.   DIRECTOR FEE OPTION GRANT PROGRAM shall mean the special stock option
grant in effect for non-employee Board members under Article Six of the Plan.

     I.   DISCRETIONARY OPTION GRANT PROGRAM shall mean the discretionary option
grant program in effect under the Plan.

     J.   ELIGIBLE DIRECTOR shall mean a non-employee Board member eligible to
participate in the Automatic Option Grant Program in accordance with the
eligibility provisions of Article One.

     K.   EMPLOYEE shall mean an individual who is in the employ of the
Corporation (or any Parent or Subsidiary), subject to the control and direction
of the employer entity as to both the work to be performed and the manner and
method of performance.

     L.   EXERCISE DATE shall mean the date on which the Corporation shall have
received written notice of the option exercise.

     M.   FAIR MARKET VALUE per share of Common Stock on any relevant date shall
be determined in accordance with the following provisions:

          (i)  If the Common Stock is at the time traded on the Nasdaq National
     Market, then the Fair Market Value shall be the closing selling price per
     share of Common Stock on the date in question, as such price is reported by
     the National Association of Securities Dealers on the Nasdaq National
     Market. If there is no closing selling price for the Common Stock on the
     date in question, then the Fair Market Value shall be the closing selling
     price on the last preceding date for which such quotation exists.

          (ii) If the Common Stock is at the time listed on any Stock Exchange,
     then the Fair Market Value shall be the closing selling price per share of
     Common Stock on the date in question on the Stock Exchange determined by
     the Plan Administrator to be the primary market for the Common Stock, as
     such price is officially quoted in the composite tape of transactions on
     such exchange. If there is no closing selling price for the Common Stock on
     the date in question, then the Fair Market Value shall be the closing
     selling price on the last preceding date for which such quotation exists.

          (iii) For purposes of any option grants made on the Underwriting Date,
     the Fair Market Value shall be deemed to be equal to the price per share at
     which the Common Stock is to be sold in the initial public offering
     pursuant to the Underwriting Agreement.

     N.   HOSTILE TAKE-OVER shall mean the acquisition, directly or indirectly,
by any person or related group of persons (other than the Corporation or a
person that directly or indirectly controls, is controlled by, or is under
common control with, the Corporation) of 

<PAGE>   53

beneficial ownership (within the meaning of Rule 13d-3 of the 1934 Act) of
securities possessing more than fifty percent (50%) of the total combined voting
power of the Corporation's outstanding securities pursuant to a tender or
exchange offer made directly to the Corporation's stockholders which the Board
does not recommend such stockholders to accept.

     O.   INCENTIVE OPTION shall mean an option which satisfies the requirements
of Code Section 422.

     P.   INVOLUNTARY TERMINATION shall mean the termination of the Service of
any individual which occurs by reason of:

          (i)  such individual's involuntary dismissal or discharge by the
     Corporation for reasons other than Misconduct, or

          (ii) such individual's voluntary resignation following (A) a change in
     his or her position with the Corporation which materially reduces his or
     her duties and responsibilities or the level of management to which he or
     she reports, (B) a reduction in his or her level of compensation (including
     base salary, fringe benefits and target bonus under any
     corporate-performance based bonus or incentive programs) by more than
     fifteen percent (15%) or (C) a relocation of such individual's place of
     employment by more than fifty (50) miles, provided and only if such change,
     reduction or relocation is effected by the Corporation without the
     individual's consent.

     Q.   MISCONDUCT shall mean the commission of any act of fraud, embezzlement
or dishonesty by the Optionee or Participant, any unauthorized use or disclosure
by such person of confidential information or trade secrets of the Corporation
(or any Parent or Subsidiary), or any other intentional misconduct by such
person adversely affecting the business or affairs of the Corporation (or any
Parent or Subsidiary) in a material manner. The foregoing definition shall not
be deemed to be inclusive of all the acts or omissions which the Corporation (or
any Parent or Subsidiary) may consider as grounds for the dismissal or discharge
of any Optionee, Participant or other person in the Service of the Corporation
(or any Parent or Subsidiary).

     R.   1934 ACT shall mean the Securities Exchange Act of 1934, as amended.

     S.   NON-STATUTORY OPTION shall mean an option not intended to satisfy the
requirements of Code Section 422.

     T.   OPTIONEE shall mean any person to whom an option is granted under the
Discretionary Option Grant, Salary Investment Option Grant, Automatic Option
Grant or Director Fee Option Grant Program.

     U.   PARENT shall mean any corporation (other than the Corporation) in an
unbroken chain of corporations ending with the Corporation, provided each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination, stock possessing fifty percent (50%) or more of the total
combined voting power of all classes of stock in one of the other corporations
in such chain.

<PAGE>   54

     V.   PARTICIPANT shall mean any person who is issued shares of Common Stock
under the Stock Issuance Program.

     W.   PERMANENT DISABILITY OR PERMANENTLY DISABLED shall mean the inability
of the Optionee or the Participant to engage in any substantial gainful activity
by reason of any medically determinable physical or mental impairment expected
to result in death or to be of continuous duration of twelve (12) months or
more. However, solely for purposes of the Automatic Option Grant and Director
Fee Option Grant Programs, Permanent Disability or Permanently Disabled shall
mean the inability of the non-employee Board member to perform his or her usual
duties as a Board member by reason of any medically determinable physical or
mental impairment expected to result in death or to be of continuous duration of
twelve (12) months or more.

     X.   PLAN shall mean the Corporation's 1997 Stock Incentive Plan, as set
forth in this document.

     Y.   PLAN ADMINISTRATOR shall mean the particular entity, whether the
Primary Committee, the Board or the Secondary Committee, which is authorized to
administer the Discretionary Option Grant and Stock Issuance Programs with
respect to one or more classes of eligible persons, to the extent such entity is
carrying out its administrative functions under those programs with respect to
the persons under its jurisdiction.

     Z.   PLAN EFFECTIVE TIME shall mean the time at which the Underwriting
Agreement is executed and finally priced.

     AA.  PREDECESSOR PLAN shall mean the Corporation's pre-existing Stock
Option Plan in effect immediately prior to the Plan Effective Time hereunder.

     BB.  PRIMARY COMMITTEE shall mean the committee of two (2) or more
non-employee Board members appointed by the Board to administer the
Discretionary Option Grant and Stock Issuance Programs with respect to Section
16 Insiders and to administer the Salary Investment Option Grant Program solely
with respect to the selection of the eligible individuals who may participate in
such program.

     CC.  SALARY INVESTMENT OPTION GRANT PROGRAM shall mean the salary
investment option grant program in effect under the Plan.

     DD.  SECONDARY COMMITTEE shall mean a committee of one or more Board
members appointed by the Board to administer the Discretionary Option Grant and
Stock Issuance Programs with respect to eligible persons other than Section 16
Insiders.

     EE.  SECTION 12 REGISTRATION DATE shall mean the date on which the Common
Stock is first registered under Section 12 of the 1934 Act.

     FF.  SECTION 16 INSIDER shall mean an officer or director of the
Corporation subject to the short-swing profit liabilities of Section 16 of the
1934 Act.

<PAGE>   55

     GG.  SERVICE shall mean the performance of services for the Corporation (or
any Parent or Subsidiary) by a person in the capacity of an Employee, a
non-employee member of the board of directors or a consultant or independent
advisor, except to the extent otherwise specifically provided in the documents
evidencing the option grant or stock issuance.

     HH.  STOCK EXCHANGE shall mean either the American Stock Exchange or the
New York Stock Exchange. II. STOCK ISSUANCE AGREEMENT shall mean the agreement
entered into by the Corporation and the Participant at the time of issuance of
shares of Common Stock under the Stock Issuance Program.

     JJ.  STOCK ISSUANCE PROGRAM shall mean the stock issuance program in effect
under the Plan.

     KK.  SUBSIDIARY shall mean any corporation (other than the Corporation) in
an unbroken chain of corporations beginning with the Corporation, provided each
corporation (other than the last corporation) in the unbroken chain owns, at the
time of the determination, stock possessing fifty percent (50%) or more of the
total combined voting power of all classes of stock in one of the other
corporations in such chain.

     LL.  TAKE-OVER PRICE shall mean the greater of (i) the Fair Market Value
per share of Common Stock on the date the option is surrendered to the
Corporation in connection with a Hostile Take-Over or (ii) the highest reported
price per share of Common Stock paid by the tender offeror in effecting such
Hostile Take-Over. However, if the surrendered option is an Incentive Option,
the Take-Over Price shall not exceed the clause (i) price per share.

     MM.  TAXES shall mean the Federal, state and local income and employment
tax liabilities incurred by the holder of Non-Statutory Options or unvested
shares of Common Stock in connection with the exercise of those options or the
vesting of those shares.

     NN.  10% STOCKHOLDER shall mean the owner of stock (as determined under
Code Section 424(d)) possessing more than ten percent (10%) of the total
combined voting power of all classes of stock of the Corporation (or any Parent
or Subsidiary).

     OO.  UNDERWRITING AGREEMENT shall mean the agreement between the
Corporation and the underwriter or underwriters managing the initial public
offering of the Common Stock.

     PP.  UNDERWRITING DATE shall mean the date on which the Underwriting
Agreement is executed and priced in connection with an initial public offering
of the Common Stock.
<PAGE>   56
                                 COMBICHEM, INC.
               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                
   The undersigned hereby appoints Vicente Anido, Jr. and Faye H. Russell
jointly and severally, as proxies, with full power of substitution and
resubstitution, to vote all shares of stock which the undersigned is entitled to
vote at the Annual Meeting of Stockholders of CombiChem, Inc. to be held on
Thursday, May 6, 1999, or at any postponements or adjournments thereof, as
specified below, and to vote in his or her discretion on such other business as
may properly come before the Annual Meeting and any adjournments thereof.

         THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR PROPOSALS 1, 2 AND 3

1.    Election of Directors:

      Nominees: Michael J. Pazzani and Peter L. Myers will stand for election to
                the Board for terms to expire in 2002.

[ ]   Vote FOR all nominees above (except as withheld in the space below)

[ ]   Vote WITHHELD from all nominees

      Instruction: To withhold authority to vote for any individual nominee,
check the box "Vote FOR" and write the nominee's name on the line below.

- -------------------------------------------------------------------------------

2.    Amend Stock Incentive Plan:

      Ratification and approval to amend the Company's 1997 Stock 
      Incentive Plan.

      [ ]    Vote FOR           [ ]    Vote AGAINST            [ ]    ABSTAIN

- -------------------------------------------------------------------------------

3.    Ratification of Accountants:

      Ratification and approval of the selection of Ernst & Young LLP as
      independent accountants for the fiscal year ending December 31, 1999.

      [ ]    Vote FOR           [ ]    Vote AGAINST            [ ]    ABSTAIN

                            (Please sign and date on reverse side)

   UNLESS OTHERWISE SPECIFIED BY THE UNDERSIGNED, THIS PROXY WILL BE VOTED FOR
PROPOSALS 1, 2 AND 3 AND WILL BE VOTED BY THE PROXYHOLDERS AT THEIR DISCRETION
AS TO ANY OTHER MATTERS PROPERLY TRANSACTED AT THE MEETING OR ANY ADJOURNMENTS
THEREOF. TO VOTE IN ACCORDANCE WITH THE BOARD OF DIRECTORS' RECOMMENDATIONS JUST
SIGN BELOW, NO BOXES NEED BE CHECKED.

                                        Dated:                       , 19


                                        Signature of Stockholder


                                        Printed Name of Stockholder


                                        Title (if appropriate)

                                        Please sign exactly as name appears
                                        hereon. If signing as attorney,
                                        executor, administrator, trustee or
                                        guardian, please give full title as
                                        such, and, if signing for a corporation,
                                        give your title. When shares are in the
                                        names of more than one person, each
                                        should sign.

            CHECK HERE IF YOU PLAN TO ATTEND THE ANNUAL MEETING. [ ]


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