PHARMACOPEIA INC
8-K, 2000-03-09
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

           PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
                                   ACT OF 1934


         Date of Report (Date of earliest event reported): March 9, 2000

                               PHARMACOPEIA, INC.
             (Exact name of registrant as specified in its charter)



           Delaware                      0-27188                33-0557266
(State or other jurisdiction of  (Commission File Number)  (IRS Employer ID No.)
        Incorporation)


CN 5350, Princeton, New Jersey                                  08543-5350
(Address of principal executive offices)                        (Zip Code)

Registrant's telephone number, including area code:             (609) 452-3600


                                 Not Applicable

          (Former name or former address, if changed from last report)


<PAGE>

Item 5.  OTHER EVENTS

         (a) On February 29, 2000, Pharmacopeia, Inc. ("Pharmacopeia") acquired
all of the issued and outstanding shares of stock of Synopsys Scientific Systems
Limited, a privately-held company located in Leeds, England ("Synopsys") for a
total purchase price of approximately $25 million (the "Acquisition"), of which
approximately $24 million of the purchase price was cash and the balance was in
common stock of Pharmacopeia. The Acquisition was consummated pursuant to the
Share Acquisition Agreement dated as of February 29, 2000 by and between
Pharmacopeia and the Persons named therein (the "Agreement").

         A copy of the Agreement is filed as an exhibit hereto and is
incorporated herein by reference.

         A copy of the press release of Pharmacopeia announcing the completion
of its acquisition of Synopsys is filed as an exhibit hereto and is incorporated
herein by reference.

         (b) Assets constituting plant, equipment or other physical property
acquired by Pharmacopeia in the Acquisition were used by Synopsys in the design,
development, marketing and sale of software products that facilitate the design
and development of pharmaceuticals and fine chemicals. Pharmacopeia currently
intends to use these assets in the same manner in which they were used prior to
the Acquisition.

         (c) Exhibits:

<TABLE>
<CAPTION>

EXHIBIT NUMBER             DESCRIPTION
<S>                        <C>
2.1                        Share Acquisition Agreement, dated as of February 29,
                           2000, by and between Pharmacopeia and the Persons
                           named therein.

99.1                       Text of Press Release, dated February 29, 2000
</TABLE>


<PAGE>

                                   SIGNATURES

                  Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

                                        PHARMACOPEIA, INC.


                                        By:/s/ Bruce C. Myers
                                           -------------------------------------
                                           Bruce C. Myers, Chief Financial
                                           Officer

                                           (Duly Authorized Officer and Chief
                                           Accounting Officer)

Date:  March 9, 2000


<PAGE>

                                  EXHIBIT INDEX

<TABLE>
<CAPTION>

EXHIBIT
<S>                        <C>
2.1                        Share Acquisition Agreement, dated as of February 29,
                           2000 by and between Pharmacopeia and the Persons
                           named therein.

99.1                       Text of Press Release, dated February 29, 2000,
                           issued by Pharmacopeia
</TABLE>


<PAGE>

                                     EX-2.1

       SHARE ACQUISITION AGREEMENT DATED FEBRUARY 29, 2000 BY AND BETWEEN
                   PHARMACOPEIA AND THE PERSONS NAMED THEREIN


<PAGE>

DATED                                                         February 29, 2000
- --------------------------------------------------------------------------------




                  (1)      THE PERSONS WHOSE NAMES AND ADDRESSES ARE SET
                           OUT IN PART A OF THE FIRST SCHEDULE


                  (2)      PHARMACOPEIA INC







- -------------------------------------------------------------------------------

                           SHARE ACQUISITION AGREEMENT

             for the exchange of the entire issued share capital of


                           SYNOPSYS SCIENTIFIC SYSTEMS
                                     LIMITED
- -------------------------------------------------------------------------------





                     (ALPHA)(BETA)(CHI)(DELTA)(EPSILON)(PHI)
                        2 Serjeants' Inn, London EC4Y 1LT
                      Tel: 0171 583 5353 Fax: 0171 353 3683



Execution
Date: 250200
Ref: C507/303701


<PAGE>

<TABLE>
<CAPTION>

CONTENTS

CLAUSE                     HEADING
<S>                        <C>
1                          Definitions and Interpretations
2                          Sale and Purchase of the Shares
3                          Consideration
4                          Completion
5                          Warranties and Representations
6                          Breach of Warranty
7                          Limitation of liability
8                          Purchaser's Warranties
9                          Undertakings by the Vendors
10                         Restrictions on the Managing Vendors
11                         [Clause intentionally deleted]
12                         Nature of obligations
13                         Announcements
14                         General
15                         Communications
16                         Proper Law

SCHEDULE                   DESCRIPTION

1                          Details of the Vendors
2                          Particulars of the Company
3                          The Properties
4                          Warranties
5                          Protection for Vendors
6                          Tax Deed

Appendix A                 The Accounts
</TABLE>


<PAGE>

DOCUMENTS IN THE AGREED FORM

                           Disclosure Letter
                           Directors' Letter of Resignation
                           Auditors' resignation
                           Letters of release from Vendors
                           Completion Board Minutes
                           Certificate of Title


<PAGE>

THIS AGREEMENT is made on 29th February 2000 BETWEEN:-

(1)               The persons whose names and addresses are set out in Part A of
                  the first schedule ("THE VENDORS");

(2)               PHARMACOPEIA, INC a corporation incorporated in the state of
                  Delaware, United States of America and having its principal
                  office at 9685 Scranton Drive, San Diego, USA 92121-3752 ("THE
                  PURCHASER"),

RECITALS

(A)               The Purchaser has offered to purchase the Shares and the
                  shares in Synopsys Scientific Systems arising upon the
                  exercise of any options granted at the date hereof under the
                  terms of the Share Option Scheme for a Consideration to be
                  satisfied by cash and/or the issue of Consideration Shares in
                  such proportion as the holders of the Shares shall elect.

(B)               The holders of the Shares at the date of this Agreement have
                  agreed to sell the Shares to the Purchaser on the terms set
                  out in this Agreement.

(C)               Prior to the exchange of the Agreement the Company has
                  resolved to pay US$250,000 (or the sterling equivalent) to the
                  EBIT.

1                 DEFINITIONS AND INTERPRETATION
- ------------------------------------------------
1.1               In this agreement unless the context otherwise requires:-

                  "ACCOUNTS" means the published statutory accounts of the
                  Company relating to the accounting reference period ended on
                  the Balance Sheet Date together with the notes, reports and
                  other documents annexed to them in the form set out in
                  Appendix A;


                                       1

<PAGE>

                  "AGREED FORM" means in a form agreed by and signed by or on
                  behalf of the parties to this agreement;

                  "ORDINARY SHARES" means Ordinary Shares of L1 each in the
                  Company;

                  "ASSOCIATE" means any person with whom any of the Vendors may
                  be connected within the meaning of section 839 of the Taxes
                  Act or for whom any of them may be a personal representative;

                  "AUDITORS" means the auditors for the time being of the
                  Company;

                  "BALANCE SHEET DATE" means 31 March 1999;

                  "PREFERRED SHARES" means Preferred Ordinary Shares of L1 each
                  in the Company;

                  "BUSINESS DAY" means a day on which banks generally are open
                  in the City of London for the transaction of normal banking
                  business;

                  "COMPANIES ACT" means the Companies Act 1985 (as amended or
                  re-enacted by the Companies Act 1989);

                  "COMPANY" means Synopsys Scientific Systems Limited details of
                  which are set out in the second schedule;

                  "COMPLETION" means the date upon which completion of the sale
                  and purchase of the Shares takes place pursuant to this
                  agreement;

                  "CONSIDERATION" means the consideration for the Shares as
                  referred to in clause 3 and columns 4 and 5 of the First
                  Schedule;

                  "CONSIDERATION SHARES" means the Common Stock of the Purchaser
                  to be issued to the Vendors pursuant to clause 3;


                                       2

<PAGE>

                  "DISCLOSURE LETTER" means the letter in the Agreed Form from
                  the Vendors to the Purchaser dated as at the date of this
                  agreement;

                  "EBIT" means the Synopsys Scientific Systems employee benefit
                  trust established pursuant to a deed of settlement a copy of
                  which is annexed to the Disclosure Letter;

                  "EVENT" includes any act, omission, transaction or
                  circumstance (including any of such matters provided for under
                  this agreement);

                  "MANAGING VENDORS" means each and any of APF Cook, KA
                  Harrington, J Hayward, G Hopkinson and P Hoyle;

                  "OPTIONHOLDERS" means the persons whose names and addresses
                  are set out in Part B of the First Schedule and "OPTION" shall
                  refer to an option granted to an Optionholder as set out in
                  Part B of the First Schedule;

                  "PENSION SCHEME" means the Vendor's pension scheme as referred
                  to in the Fourth schedule;

                  "PROPERTIES" means the properties briefly described in the
                  Property Schedule or any part of or interest in any such
                  properties (and a reference to the "property" is to either or
                  both of those properties);

                  "PROPERTY SCHEDULE" means the Third Schedule;

                  "PURCHASER'S SOLICITORS" means Titmuss Sainer Dechert of 2
                  Serjeants' Inn, London EC4Y 1LT;

                  "REVENUE" means all fiscal authorities (national or local)
                  whether of the United Kingdom or elsewhere;


                                       3

<PAGE>

                  "SECURITIES ACT" means the Securities Act of 1933 of the
                  United States of America;

                  "SHARES" means the whole of the issued and allotted share
                  capital of the Company at Completion.;

                  "SHARE OPTION SCHEME" means the Synopsys Scientific Systems
                  Inland Revenue Approved Executive Share Option Scheme;

                  "TAXATION" means all forms of taxation, duties (including
                  stamp duty), levies, imposts, charges, withholdings, national
                  insurance and other contributions, rates and PAYE liabilities
                  (including any related or incidental penalty, fine, interest
                  or surcharge) whether of the United Kingdom or elsewhere;

                  "TAX DEED" means a deed in the form set out in the Sixth
                  Schedule duly executed by the Covenantors referred to in it;

                  "TAXES ACT" means the Income and Corporation Taxes Act 1988;

                  "TRUST VENDORS" means the trustees of the AJD Katritzky
                  Revocable Trust and KB (CI) Nominees Limited;

                  "VENDORS' SOLICITORS" means Walker Morris, of Kings Court, 12
                  King Street, Leeds, LS1 2HL;

                  "WARRANTIES" means the representations, warranties and
                  undertakings on the part of the Vendors contained in the
                  Fourth Schedule and which are made by the Vendors pursuant to
                  clause 5;

1.2               In this agreement unless the context otherwise requires:-


                                       4

<PAGE>

1.2.1             any reference to a clause, schedule or appendix (other than to
                  a schedule to a statutory provision) is a reference to a
                  clause of or schedule or appendix to this agreement; and the
                  schedules and appendices form part of and are deemed to be
                  incorporated in and in references to this agreement;

1.2.2             any reference to a statute or statutory provision includes a
                  reference to that provision as amended, re-enacted or replaced
                  and any regulations or orders made under such provisions from
                  time to time whether before or after the date of this
                  agreement and any former statutory provision replaced (with or
                  without modification) by the provision referred to except to
                  the extent that any amendment, re-enactment or replacement
                  coming into force after the date of this agreement would
                  increase or extend the liability of the parties to one
                  another;

1.2.3             any reference to persons includes a reference to firms,
                  corporations or unincorporated associations;

1.2.4             any reference to the singular includes a reference to the
                  plural and vice versa; and any reference to the masculine
                  includes a reference to the feminine and vice versa;

1.2.5             a reference to an SSAP is a reference to a Statement of
                  Standard Accounting Practice which has been adopted as an
                  accounting standard by the Accounting Standards Board;

1.2.6             any agreement, warranty, representation, indemnity, covenant
                  or undertaking on the part of two or more persons shall be
                  deemed to be given or made by such persons severally and
                  proportionately namely in



                                       5

<PAGE>

                  the proportion which the Consideration received or receivable
                  by a Vendor pursuant to this agreement bears to the total
                  Consideration;

1.2.7             any matter which shall be relevant to any of the Vendors and
                  which be known to at least one of the Vendors shall be deemed
                  to be known by the other Vendors as well;

1.2.8             words and expressions defined in the Companies Act bear the
                  same respective meanings; and

1.2.9             any reference to indemnifying any person against any
                  circumstance includes indemnifying and holding that person
                  harmless from all actions, claims, demands and proceedings of
                  any nature from time to time made against that person and all
                  losses, damages, payments, awards costs or expenses made,
                  suffered or incurred by that person as a consequence of that
                  circumstance.

1.3               Headings and titles are used for ease of reference only and do
                  not affect the interpretation of this agreement.

1.4               Unless otherwise specified in this agreement, if any statement
                  is qualified by the expression "TO THE BEST OF THE VENDORS'
                  KNOWLEDGE INFORMATION AND BELIEF" or "SO FAR AS THE VENDORS
                  ARE AWARE" or any similar expression, that expression shall be
                  deemed to include a warranty by the makers thereof that the
                  statement has been made by them after due and careful enquiry.


                                       6

<PAGE>

2                 SALE AND PURCHASE OF THE SHARES
- -------------------------------------------------
2.1               The Vendors shall sell the Shares to the Purchaser and the
                  Purchaser, relying on the Warranties and the other obligations
                  of the Vendors under this agreement, shall purchase the
                  Shares.

2.2               The Vendors shall transfer the Shares with full title
                  guarantee (except for the Trustee Vendors who shall transfer
                  the Shares owned by them with limited title guarantee) free
                  from all liens, charges, encumbrances and adverse claims (and
                  whether or not the Vendors know or could reasonably be
                  expected to know about such matters) together with all rights
                  now or hereafter attaching to them including all dividends
                  declared or payable or distributions made or proposed on or
                  after the date of this agreement.

2.3               The Vendors irrevocably and unconditionally waive (and shall
                  procure such a waiver by their nominee(s) of) all rights of
                  pre-emption or other restrictions on transfer which they or
                  such nominee(s) may have, whether under the Articles of
                  Association of the Company or otherwise, in respect of the
                  transfer to the Purchaser or its nominee(s) of the Shares or
                  any of them and shall execute and deliver (or procure the
                  execution and delivery of) all such deeds of waiver in respect
                  thereof as the Purchaser may require.

2.4               The Purchaser shall not be obliged to complete the exchange of
                  some only of the Shares unless the exchange of all the Shares
                  is completed simultaneously in accordance with the provisions
                  of this agreement.


                                       7

<PAGE>

3                 CONSIDERATION
- -------------------------------
3.1               The aggregate consideration for the sale and purchase of the
                  Shares shall be US$24,750,000 (twenty four million, seven
                  hundred and fifty thousand) to be satisfied by:

3.1.1             the issue and allotment by Pharmacopeia to the Vendors of the
                  Consideration Shares in the amounts set out in column 4 of
                  Part A of Schedule 1; and

3.1.2             the payment of cash consideration to the Vendors in the
                  amounts set out in column 5 of Part A of Schedule 1.

3.2               The cash consideration shall be payable on completion by CHAPS
                  transfer to Walker Morris client account at The Royal Bank of
                  Scotland, account number 00282443, sort code 16-23-37. Payment
                  to the above account will be good and sufficient discharge and
                  Pharmacopeia will not be further concerned as to the
                  application of the monies so paid.

3.3               The Consideration Shares shall be issued fully paid (or
                  credited as fully paid), non-assessable, and shall rank pari
                  passu in all respects with the issued and outstanding shares
                  of common stock of the Purchaser (other than in respect of
                  registration), including the right to receive all dividends or
                  distributions declared, paid or made after the date of this
                  Agreement. The parties acknowledge that the Consideration
                  Shares have not been registered pursuant to the Securities
                  Act, as amended.

3.4               No fractional Consideration Shares shall be issued and the
                  Purchaser shall, where any fractional Consideration Share
                  would result, be entitled to limit


                                       8

<PAGE>

                  the Consideration Shares to the nearest lower whole number of
                  Consideration Shares resulting.

3.5               The Purchaser agrees unconditionally to offer no later than 3
                  March 2000 to purchase all Ordinary Shares issued before that
                  date upon the exercise of an Option at the same price per
                  share as the Shareholders including cash/shares to be
                  satisfied in cash and/or Consideration Shares at the election
                  of the Optionholder On terms that the completion of such
                  purchase is completed no later than 3 March 2000 and the
                  provisions of clauses 3.2,3.3 and 3.4 shall apply.

3.6               Pharmacopeia covenants with each of the Vendors that within 7
                  days of Completion it will procure that the Company
                  contributes US$250,000 (or the Sterling equivalent of this
                  amount) to the EBIT in accordance with the resolution of the
                  board of the Company referred to in Recital (C).

3.7               The Company has been notified in writing by each of the
                  Optionholders that each Optionholder intends to exercise his
                  Option in full and to accept the offer of the Purchaser as
                  referred to in clause 3.5 when such offer is made.

3.8               The Purchaser undertakes, subject to receipt of necessary
                  information from the Vendors, to use its best endeavours to
                  file with the US Securities Exchange Commission, as soon as
                  practicable, but in no event later than thirty (30) days after
                  Completion, a registration statement to enable the resale of
                  the Consideration Shares by the Vendors, and use its
                  reasonable efforts, subject to receipt of all necessary
                  information from the Vendors, to


                                       9

<PAGE>

                  cause the registration statement to become effective as soon
                  as practicable, but in no event later than ninety (90) days
                  after Completion. The Vendors undertake to comply with the
                  applicable provisions of the Securities Act and other
                  applicable securities laws in connection with their
                  disposition of their Consideration Shares pursuant to such
                  registration statement.

4                 COMPLETION
- ----------------------------
4.1               Completion shall take place at the offices of the Purchaser's
                  Solicitors immediately after the exchange of this agreement
                  when the parties shall comply with their respective
                  obligations as set out in this clause.

4.2               The Vendors shall deliver to the Purchaser or (at the option
                  of the Purchaser) to its nominee(s):-

4.2.1             duly executed share transfers in respect of the Shares in
                  favour of the Purchaser or as it may direct, together with the
                  relevant share certificates or other documents of title and
                  any power of attorney or other authority under which such
                  transfers have been executed and an indemnity in such form as
                  the Purchaser shall require in relation to any missing
                  certificates;

4.2.2             written resignations and releases executed as deeds in the
                  Agreed Form from all persons (other than any directors or
                  secretaries remaining at the request of the Purchaser or
                  appointed at the instance of the Purchaser) who, on or
                  immediately prior to Completion, may be directors or
                  secretaries of the Company, resigning their offices and
                  releasing the Company from all claims and rights of action
                  whether by way of compensation, remuneration, redundancy
                  payments or otherwise except


                                       10

<PAGE>

                  for accrued remuneration and reasonable expenses (if any) for
                  the month then current at the respective rates disclosed in
                  the Disclosure Letter;

4.2.3             [Clause deleted]

4.2.4             the unqualified resignation with effect from Completion of the
                  present Auditors as auditors of the Company by a notice in
                  accordance with section 392 of the Companies Act which shall
                  contain a statement in accordance with section 394 of the
                  Companies Act together with confirmation that they have no
                  claims against the Company for unpaid fees or expenses;

4.2.5             the common seal, the certificates of incorporation and copies
                  of the Memorandum and Articles of Association (containing
                  copies of all such resolutions and agreements as are referred
                  to in section 380 of the Companies Act) of the Company and the
                  registers and books required by the Companies Act to be kept
                  by it all of which shall be written up to date as at
                  Completion;

4.2.6             certificate of title in the Agreed Form to the Property and
                  all deeds and documents of title relating to the Property
                  (including all insurances policies, premium receipts,
                  maintenance contracts and other documents relating to the
                  Property) and certified copies of any documents being held by
                  mortgagees;

4.2.7             a letter from the Vendors specifying the whereabouts of any
                  other documents, books and records of the Company which are
                  not held at the



                                       11

<PAGE>

                  Property and directing the holders of them to deliver them up
                  to the Purchaser's authorised representatives immediately upon
                  request;

4.2.8             service agreements in the Agreed Form between the Company and
                  each of Dr GA Hopkinson, Dr J Hayward, Mr APF Cook, Dr PLM
                  Hoyle and Dr KA Harrington signed by each of those
                  individuals;

4.2.9             powers of attorney in the Agreed Form executed by each Vendor;

4.2.10            the Tax Deed; and

4.2.11            if required by the Purchaser, evidence to the satisfaction of
                  the Purchaser that any person executing this agreement or any
                  document to be executed pursuant to it has authority to do so.

4.2.13            a deed of termination, in Agreed Form, in relation to the
                  Shareholders' Agreement relating to the Company amongst the
                  Vendors.

4.3               The Vendors shall on the Completion Date:-

4.3.1             procure that none of them or any of their Associates has any
                  claims or rights of action against the Company and that the
                  Company is not in any way obligated or indebted to any of them
                  or to any such Associates save in relation to their terms of
                  employment with the Company; and

4.3.2             procure that each of them and their Associates shall have
                  repaid to the Company all sums which may be owed by any of
                  them to the Company on any account whatsoever, whether or not
                  such sums shall be due and payable on or before the Completion
                  Date;

4.3.3             deliver to the Purchaser's Solicitors letters executed as
                  deeds in the Agreed Form confirming that they have complied
                  with clauses 4.3.1 and


                                       12

<PAGE>

                  4.3.2 and irrevocably and unconditionally releasing the
                  Company from all obligations and liabilities as contemplated
                  by clause 4.3.1.

4.4               The Vendors shall procure that a Board Meeting of the Company
                  will be held which will transact the matters referred to in
                  the board minutes of the Company in the Agreed Form.

4.5               Subject to the conclusion of the matters referred to in the
                  previous provisions of this clause:-

4.5.1             the Purchaser shall pay to the Vendors the cash consideration
                  and allot and issue the Consideration Shares to the Vendors
                  and deliver to the Vendors' Solicitors:-

4.5.1.1           the Vendors shall be entered in the Purchaser's Stock Transfer
                  Books as the holders of those shares and definitive share
                  certificates in the names of the Vendors in respect of the
                  Consideration Shares shall be delivered as soon as practical
                  after Completion;

4.5.1.2           a counterpart Tax Deed duly executed by the Purchaser;

5                 WARRANTIES AND REPRESENTATIONS
- ------------------------------------------------
5.1               The Vendors represent and warrant to and undertake with the
                  Purchaser that, save only as and to the extent fairly
                  disclosed to the Purchaser in this agreement or in the
                  Disclosure Letter, each of the Warranties:-

5.1.1             is true and accurate; and

5.1.2             is not affected or limited by any previous or other
                  disclosures, express or implied, to the Purchaser, its
                  officers, representatives or professional advisers.


                                       13

<PAGE>

5.2               Each of the Warranties, covenants, indemnities and
                  undertakings set out in this agreement or the Tax Deed is
                  separate and independent.

5.3               The Vendors agree with the Purchaser for itself and as trustee
                  for the Company and each of their respective officers and
                  employees to irrevocably and unconditionally waive any rights
                  remedies or claims which they may have in respect of any
                  misrepresentation in or omission from any information or
                  advice supplied or given by the Company or its respective
                  officers, employees or agents and on which they have relied in
                  giving the Warranties, unless such misrepresentation or
                  omission was made fraudulently in preparing the Disclosure
                  Letter or in agreeing to give the Tax Deed.

6                 BREACH OF WARRANTY
- ------------------------------------
6.1               Without restricting the rights or the ability of the Purchaser
                  to claim damages on any basis if it shall be found that any
                  matter which is the subject of any of the Warranties is not as
                  represented, warranted or undertaken then, if the Purchaser
                  shall so elect by notice in writing to them, the Vendors shall
                  on demand pay to the Purchaser a sum equal to the amount by
                  which the value (or amount) at the date of this agreement of
                  any asset or liability of the Company (computed for this
                  purpose on the basis that full provision was made for the
                  facts and circumstances in relation to which such breach
                  arose) was less or, in the case of a liability, greater than
                  the value (or amount) at the date of this agreement
                  respectively of such asset or liability (computed for this
                  purpose on the


                                       14

<PAGE>

                  assumption that the facts and circumstances had been such as
                  to involve no such breach) and including all costs and
                  expenses incurred by the Company and/or the Purchaser as a
                  result of such breach, subject to the limitations on liability
                  specified in clause 7 and the Fifth Schedule of this
                  agreement.

6.2.1             Each of the Vendors will forthwith notify (in writing) the
                  Purchaser of any matter or thing which becomes known to the
                  relevant Vendor after the date of this agreement (whether or
                  not prior to Completion) which is inconsistent with any of the
                  Warranties or would or is likely to give rise to a claim under
                  the Warranties or the Tax Deed of an amount in excess of
                  L5,000.

6.2.2             Any matter or thing notified under clause 6.2.1 shall not be
                  and shall not be deemed to be a disclosure for the purpose of
                  qualifying or limiting the liability of the Vendors pursuant
                  to this agreement or the Tax Deed.

7                 LIMITATION OF LIABILITY
- -----------------------------------------
7.1               The following provisions of this clause 7 and the Fifth
                  Schedule shall operate to limit the liability of the Vendors
                  under the Agreement, the Warranties and/or the Tax Deed and
                  references to "BREACH", "CLAIM" and "LIABILITY" (and any
                  similar expression) shall, unless the context otherwise
                  requires, be references to a breach of or a claim or liability
                  arising under the Warranties and/or the Tax Deed
                  notwithstanding any other provisions contained in this
                  agreement.


                                       15

<PAGE>

7.2               No claim shall be made under the Warranties or under the Tax
                  Deed unless the Vendors shall have been given written notice
                  of that claim specifying in reasonable detail the matter which
                  gives rise to the breach or claim, the nature of the breach or
                  claim and the amount claimed as soon as practicable just after
                  the Purchaser becomes aware of the breach by or on behalf of
                  the Purchaser prior to the first anniversary of Completion
                  other than such a liability which shall arise from fraud or
                  wilful default in which case there shall be no limitation.
                  Provided that the Vendors liability in respect of any claim
                  shall absolutely determine (if such claim has not been
                  satisfied settled or withdrawn) if legal proceedings in
                  respect of such claim have not been commenced within six
                  months (or in the case of a liability relating to Taxation, 18
                  months) of the service of the notice of such claim and for
                  this purpose proceedings shall not be deemed to have commenced
                  unless they have been properly issued and reasonable steps
                  have been taken to validly serve them on the Vendors.

8                 PURCHASER'S WARRANTIES
- ----------------------------------------
                  The Purchaser warrants to the Vendors as follows:

8.1               The Purchaser has the full power and authority to issue and
                  allot the Consideration Shares.

8.2               The Purchaser has full power and authority to enter into this
                  agreement and the other documents to be executed in connection
                  with it all of which constitute or will immediately after
                  Completion constitute legal and valid binding obligations on
                  the Purchaser enforceable in accordance with their respective
                  terms.


                                       16

<PAGE>

8.3               The Purchaser is a corporation duly organised and validly
                  existing under the laws of its state of incorporation with
                  full corporate power and authority to effect the transactions
                  contemplated by this agreement.

8.4               The Purchaser is duly qualified to do business and is in good
                  standing in each jurisdiction in which the nature of the
                  business conducted by it or the property it owns, leases or
                  operates requires it to so qualify, and where the failure to
                  so qualify will have a material adverse effect on the
                  Purchaser.

8.5               The Purchaser has all requisite corporate power and authority
                  to enter into and deliver this Agreement to perform its
                  obligations hereunder and to consummate the transactions
                  contemplated by this Agreement. The execution and delivery of
                  this Agreement and the consummation of the transactions
                  contemplated hereby by the Purchaser have been duly authorised
                  by all necessary corporate action on the part of the
                  Purchaser.

8.6               This Agreement has been duly executed and delivered by the
                  Purchaser and constitutes the legal, valid and binding
                  obligation of the Purchaser enforceable against it in
                  accordance with its terms.

8.7               Neither the execution and delivery of this Agreement by the
                  Purchaser nor the consummation of the transactions
                  contemplated hereby will:

8.7.1             conflict with, or result in a breach of any provision of the
                  Purchaser Articles or the Purchaser By-Laws;

8.7.2             violate, or conflict with, or result in a breach of any
                  provision of, or constitute a default (or an Event that, with
                  the giving of notice, the passage of time or otherwise, would
                  constitute a default) to terminate, accelerate,


                                       17

<PAGE>

                  modify or call a default under, or resulting in the creation
                  of any lien, security interest, charge or encumbrance upon any
                  of the properties or assets of the Purchaser or any of its
                  subsidiaries under, any of the terms, conditions or provisions
                  of any note, bond, mortgage, indenture, deed of trust,
                  license, contract, undertaking, agreement, lease or other
                  instrument or obligation to which the Purchaser or any of its
                  subsidiaries is a party, except for such breaches, defaults or
                  other occurrences which would not, individually or in the
                  aggregate, have a material adverse effect;

8.7.3             violate any order, writ, injunction or decree, except for such
                  violations, individually or in the aggregate, which would not
                  have a material adverse effect on the Purchaser and its
                  subsidiaries taken as a whole;

8.7.4             require any action or consent or approval of, or review by, or
                  registration or filing by the Purchaser or any of its
                  affiliates with any third party or any local, domestic,
                  foreign or multi-national court, arbitral, tribunal,
                  administrative agency or commission or other governmental or
                  regulatory body, agency, instrumentality or authority (a
                  "GOVERNMENTAL Authority").

8.8               The Purchaser has filed with the Securities and Exchange
                  Commission (the "COMMISSION") all forms, reports, schedules,
                  statement and other documents required to be filed by it since
                  1 January 1996 under the Exchange Act or the Securities Act
                  (such documents as supplemented and amended since the time of
                  filing, collectively, the PURCHASER'S SEC DOCUMENTS). The
                  Purchaser's SEC Documents, including, without


                                       18

<PAGE>

                  limitation, any financial statements or schedules included
                  therein, at the time filed (and, in the case of registration
                  statements and proxy statements, on the dates of effectiveness
                  and the dates of mailing, respectively and in the case of any
                  of the Purchaser's SEC Documents amended or superseded by a
                  filing prior to the date of this Agreement, then on the date
                  of such amending or superseding filing):

8.8.1             did not contain any untrue statement of a material fact or
                  omit to state a material fact required to be stated therein or
                  necessary in order to make the statements therein, in light of
                  the circumstances under which they were made, not misleading;
                  and

8.8.2             complied in all material respects with the applicable
                  requirements of the Securities and Exchange Act of 1934
                  (together with the rules and regulations thereunder, the
                  EXCHANGE ACT) and the Securities Act, as the case may be. The
                  financial statements of the Purchaser included in the
                  Purchaser SEC Documents at the time filed (and, in the case of
                  registration statements and proxy statements, on the dates of
                  effectiveness and the dates of mailing, respectively, and, in
                  the case of any of the Purchaser's SEC Documents amended or
                  superseded by a filing prior to the date of the Agreement then
                  on the date of such amending or superseding filing) (i)
                  complied as to form in all material respects with the
                  published rules and regulations of the Commission with respect
                  thereto, (ii) were prepared in accordance with generally
                  accepted accounting principles applied on a consistent basis
                  during the periods involved


                                       19

<PAGE>

                  (except as may be indicated in the notes thereto or, in the
                  case of unaudited statements, as permitted by Form 10-Q of the
                  Commission), and except that unaudited financial statements
                  may not contain footnotes and are subject to year-end
                  adjustments which will not individually or in the aggregate,
                  be material in magnitude, and (iii) fairly present (subject in
                  the case of unaudited statements, to normal, recurring audit
                  adjustments) the consolidated financial position of the
                  Purchaser and its consolidated subsidiaries as at the dates
                  thereof and the consolidated results of their operations for
                  the periods then ended.

8.9               The Purchaser and each of its subsidiaries is in compliance,
                  and at all times since 1 January 1996 has been in compliance,
                  with all applicable laws, statutes, orders, rules,
                  regulations, policies or guidelines promulgated, or
                  judgements, decisions or orders entered by an Governmental
                  Authority (collectively, APPLICABLE LAWS) relating to the
                  Purchaser and each of its subsidiaries or their respective
                  business or properties, except where the failure to be in
                  compliance with such Applicable Laws (individually or in the
                  aggregate) would not have a material adverse effect on the
                  business, results of operations or financial condition on the
                  Purchaser. No investigation or review by any Governmental
                  Authority with respect to the Purchaser or any of its
                  subsidiaries is pending, or, to the knowledge of the
                  Purchaser, threatened, nor has any Governmental Authority
                  indicated in writing an intention to conduct the same other
                  than those the outcome of which would not have a


                                       20

<PAGE>

                  material adverse effect on the business, results of operations
                  or financial condition on the Purchaser.

8.10.1            Except as stated in the Purchaser's SEC Documents, there is no
                  suit, claim, action, proceeding, hearing, notice of violation,
                  demand letter or investigation (an ACTION) pending or, to the
                  knowledge of the Purchaser (or its executive officers or
                  directors), threatened against the Purchaser, any of its
                  subsidiaries or any of their respective executive officers or
                  directors that, individually or in the aggregate, would have a
                  material adverse effect on the business, or financial
                  condition of the Purchaser. Neither the Purchaser nor any of
                  its subsidiaries is subject to any outstanding order, writ,
                  injunction or decree that, individually or in the aggregate,
                  that would have a material adverse effect on the Purchaser and
                  its subsidiaries, taken as whole.

8.10.2            There is no Action presently pending or to the knowledge of
                  the Purchaser (or its executive officers or directors),
                  threatened against the Purchaser or any of its subsidiaries
                  relating to any alleged hazard or alleged defect in design,
                  manufacture, materials or workmanship, including without
                  limitation any failure to warn or alleged breach of express or
                  implied warranty or representation, relating to any produce
                  manufactured, distributed or sold by or on behalf of the
                  Purchaser or any of its subsidiaries which, if adversely
                  determined, would have a material adverse effect on the
                  business, results of operations or financial condition of the
                  Purchaser.


                                       21

<PAGE>

8.11              Since 30 September 1999, there has been no material adverse
                  change in the business, results of operations or financial
                  condition of the Purchaser other than any Event, occurrences
                  and developments that would not, individually or in the
                  aggregate, have or reasonably be expected to have a material
                  adverse effect on the business, results of operations or
                  financial condition of the Purchaser or a material adverse
                  effect on the liability of the Purchaser to consummate the
                  transaction contemplated hereby.

8.12              The Board of Directors of the Purchaser, at a meeting duly
                  called and held, has determined that this Agreement and the
                  transactions contemplated hereby, including the Acquisition,
                  taken together are in the best interests of the Purchaser and
                  its stockholders.

9                 UNDERTAKINGS BY THE VENDORS
- ---------------------------------------------
9.1               The Vendors undertake to the Purchaser that as soon as
                  possible following Completion they will procurethe execution
                  of any document which the Purchaser may reasonably require
                  them to have executed so as to vest effectively the beneficial
                  and legal ownership of the Shares in the Purchaser or as it
                  may direct free from all liens, charges, encumbrances and
                  adverse claims and otherwise to give effect to the terms of
                  this agreement;

9.2               Subject to clause 7 and the Fifth Schedule, the Vendors shall
                  indemnify the Company against all claims which may be made
                  against it by any person whose resignation from office or
                  relinquishment of rights the Vendors may be obliged to procure
                  in order to comply with this agreement


                                       22

<PAGE>

                  by reason of the resignation or removal from office or
                  termination of employment of such person and against all costs
                  incurred by it which are incidental to any such claim.

9.3               The Vendors undertake with the Purchaser that, if and for so
                  long as they remain the registered holders of any of the
                  Shares after Completion, they will hold the Shares and the
                  dividends and other distributions of profits or surplus or
                  other assets in respect of such Shares and all rights arising
                  out of or in connection with them in trust for the Purchaser
                  and will at all times after Completion deal with and dispose
                  of such Shares, dividends, distributions and rights as the
                  Purchaser shall direct and (if so requested by the Purchaser)
                  execute all instruments of proxy or other documents which may
                  be necessary or proper to enable the Purchaser to attend and
                  vote at any meeting of the Company.

10.               RESTRICTIONS ON THE MANAGING VENDORS
- ------------------------------------------------------
10.1              In this clause:-

                  "BUSINESS" means the business of the development, licensing
                  and maintenance of chemical database, software systems and
                  chemical data content and the provision of consultancy
                  services to support pharmaceutical discovery research or any
                  part thereof now carried on by the Company;

                  "DIRECTLY OR INDIRECTLY" means (without prejudice to the
                  generality of the expression) either alone or jointly or in
                  partnership with any other person, firm or company or (except
                  as the holder for investment purposes only of


                                       23

<PAGE>

                  securities in any company not exceeding 3 per cent in nominal
                  value of the securities of that class in issue or shares) as
                  the holder of any interest in or as an employee director agent
                  or representative of or consultant to any other person firm or
                  company; and

                  "RESTRICTION AREA" means any or all of the following:

                  -   United Kingdom

                  -   the European Union (other than the United Kingdom); and

                  -   the USA

                  -   Japan;

                  "RESTRICTION PERIOD" means the period of 3 years from
                  Completion.

10.2              Each of the Managing Vendors severally undertakes to the
                  Purchaser (for itself and for the benefit of the Company) that
                  he will not (other than for and on behalf of the Company)
                  without the prior written consent of the Purchaser directly or
                  indirectly:-

10.2.1            at any time during the Restriction Period in the Restriction
                  Area be engaged or concerned or interested or participate in
                  or carry on any business which is in competition with the
                  Business anywhere in the Restricted Area;

10.2.2            at any time during the Restriction Period in the Restriction
                  Area in relation to a business which is the same as or in
                  competition with the Business, canvass, solicit or entice the
                  custom of or deal with or supply any goods or services which
                  are the same as or in competition with the goods and services
                  of the Business to any person who at the date of this
                  agreement or at any time during the period of two years prior
                  to Completion has been a


                                       24

<PAGE>

                  customer or client of or in the habit of dealing with the
                  Business in respect of such goods and services and with whom
                  the Vendor shall have had personal contact during such two
                  year period; or

10.2.3            at any time during the Restriction Period offer employment to
                  or employ or offer or conclude any contract for services with
                  any person who as at Completion shall be a director, employee,
                  consultant or agent of the Company entitled to emoluments
                  (including commission if any) exceeding the annual rate of
                  L25,000; or

10.2.4            at any time during the Restriction Period in the Restriction
                  Area knowingly assist any competitor of the Company to a
                  material extent in carrying on or developing any business
                  which is in competition with the Business; or

10.2.5            at any time during the Restriction Period in the Restriction
                  Area seek to contract with or engage any person who has been
                  contracted with or engaged to manufacture, assemble, supply or
                  deliver products, goods, materials or services to the Company
                  in respect of such goods and services at any time during the
                  period of twelve months prior to Completion; or

10.2.6            at any time employ, solicit or entice or endeavour to entice
                  any employee earning in excess of L25,000 of the Company away
                  from the Company; or

10.2.7            at any time entice or endeavour to entice any person to breach
                  his contract for services with the Company;

10.2.8            except as required by law at any time disclose to any person
                  or use for his own benefit (or that of any other person) any
                  information or know-how of


                                       25

<PAGE>

                  a confidential nature concerning and relating to the goodwill
                  of the Company including (without limitation) information and
                  know-how as to products, processes, techniques, suppliers,
                  customers, finances, business policy and expansion or forward
                  planning programmes which he shall have acquired before
                  Completion; or

10.2.9            at any time falsely represent himself as being connected with
                  or interested in the Company; or

10.2.10           except as required by law at any time do or say anything
                  likely or calculated to lead any person, firm or company to
                  withdraw from or cease to continue offering to the Company any
                  rights (whether of purchase, sale, import, distribution,
                  agency or otherwise) then enjoyed by it or in any other way to
                  cease to do business or reduce the amount of business it
                  transacts with the Company or any member of the Company's
                  group; or

10.2.11           at any time carry on a business under the name "Synopsys
                  Scientific Systems" or any part combination or abbreviation
                  thereof or any similar or other name likely to confuse or
                  mislead any part of the public.

10.3              Each of the Managing Vendors acknowledges and agrees with the
                  Purchaser that:-

10.3.1            each of the sub-clauses contained in clause 10.2 constitutes
                  an entirely separate severable and independent covenant by and
                  restriction on him;

10.3.2            the duration, extent and application of each of the
                  restrictions contained in clause 10.2 are no greater than is
                  necessary for the protection of the


                                       26

<PAGE>

                  goodwill and trade connections of the Business and the value
                  of the Company; and

10.3.3            if any restriction contained in clause 10.2 shall be found
                  void but would be valid if some part thereof were deleted such
                  restriction shall apply with any such deletion as may be
                  necessary to make it valid and effective].

11.               CLAUSE DELETED INTENTIONALLY

12                NATURE OF OBLIGATIONS

12.1              Each of the obligations, representations, warranties,
                  indemnities and undertakings entered into or made by or on
                  behalf of any of the parties to this agreement (excluding any
                  obligation fully performed at Completion) shall continue in
                  full force and effect notwithstanding Completion taking place.

12.2              The rights and remedies of the Purchaser in respect of a
                  breach of any provision of this agreement or pursuant to the
                  Tax Deed shall not be affected by Completion or by whether the
                  matters constituting such breach or other matters were known
                  or could have been known by the Purchaser prior to Completion
                  and no such actual or constructive knowledge shall in any way
                  constitute a waiver of any of the Purchaser's rights.

12.3              Any right or remedy of the Purchaser in respect of a breach of
                  any provision of this agreement shall be in addition and
                  without prejudice to all other rights and remedies of the
                  Purchaser and the exercise or failure to exercise any such
                  right or remedy by the Purchaser shall not constitute a waiver
                  or by the Purchaser of that or of any of its other rights or
                  remedies.


                                       27

<PAGE>

12.4              None of the rights or obligations referred to in this
                  agreement may be assigned or transferred to any other person
                  without the prior written consent of all the parties to this
                  agreement.

13                ANNOUNCEMENTS

                  None of the parties to the agreement will either before or
                  after Completion, and in relation to the Purchaser only for a
                  period of 1 year after Completion, make any announcement or
                  issue any circular to the press or shareholders or the
                  employees, suppliers or customers of the Company (otherwise
                  than as required by law or in accordance with the requirements
                  of The Stock Exchange or the Panel on Takeovers and Mergers or
                  the US Securities and Exchange Commission) or the employees,
                  suppliers or customers of the Company concerning the terms and
                  conditions of this agreement without the text of such
                  announcement or circular first being approved by the other
                  parties (such approval not to be unreasonably withheld or
                  delayed) but nothing shall restrict the Vendors from making
                  such disclosures to the directors of the Company as may be
                  reasonably necessary for the proper performance by such
                  directors of their duties.

14                GENERAL

14.1              This agreement together with any other documents which this
                  agreement expressly requires shall be signed shall constitute
                  the entire understanding and agreement between the parties to
                  it in relation to the subject matter of this agreement.


                                       28

<PAGE>

14.2              Any variation of this agreement shall be binding only if it is
                  recorded in a document signed by or on behalf of the parties
                  to this agreement.

14.3              Each party shall pay its own costs in relation to the
                  negotiations leading up to the sale of the Shares and to the
                  preparation, execution and carrying into effect of this
                  agreement and of all the other documents referred to in it.

14.5              Time shall be of the essence of this agreement.

14.6              This agreement may be signed in any number of separate
                  counterparts but shall not take effect until each party has
                  signed at least one counterpart.

15                COMMUNICATIONS

15.1              All communications between the parties with respect to this
                  agreement shall be in writing and delivered by hand or sent by
                  pre-paid post, (first class if inland, airmail if overseas) or
                  facsimile telecopier ("FAX") to the address of the addressee
                  as set out in this agreement, or to such other address or fax
                  number in England as the addressee may from time to time have
                  notified for the purposes of this clause [or as specified in
                  clause 15.2].

15.2              Communications shall be deemed to have been received:-

15.2.1            if delivered by hand, on the day of delivery;

15.2.2            if sent by first class post, two Business Days after posting
                  exclusive of the day of posting (or five Business Days in the
                  case of a posting to an address outside the United Kingdom);


                                       29

<PAGE>

15.2.3            if sent by fax at the time of transmission or, if the time of
                  transmission is not during the addressee's normal business
                  hours, at 9.30 a.m. on the next Business Day;

15.3              Communications addressed to the Vendors shall be sent to:

                  Walker Morris, Kings Court, 12 King Street, Leeds,

                  Fax No.0113 245 9412

                  and marked for the attention of "Ian Gilbert";

                  Communications addressed to the Purchaser shall be sent to:

                  1.       Titmuss Sainer Dechert, 2 Serjeants' Inn,
                           London EC4Y 1LT
                           Fax No. 0171 353 3683/2830
                           and marked for the attention of "David Vogel"

                  2.       Dechert Price & Rhoads, Princeton Pike Corporate
                           Center, PO Box 5218, Princeton, NJ 08543-5218, USA
                           Fax No. (609) 620 3259
                           and marked for the attention of "James Marino".

                  3.       The Purchaser, 9685 Scranton Road, San Diego, CA
                           92121-3752, USA
                           Fax No. 001 619 450 5041
                           and marked for the attention of "Tom Carney"

15.4              In proving service:-

15.4.1            by delivery by hand, it shall be necessary only to produce a
                  receipt for the communication signed by or on behalf of the
                  addressee;


                                       30

<PAGE>

15.4.2            by post, it shall be necessary only to prove that the
                  communication was contained in an envelope which was duly
                  addressed and posted in accordance with this clause; and

15.4.3            by fax it shall be necessary only for the communication or a
                  confirmatory letter to have been delivered by hand or sent by
                  first class post on the same day but failure of the addressee
                  to receive such confirmation shall not invalidate the relevant
                  communication deemed given by fax.

16                PROPER LAW
- ----------------------------
16.1              This agreement shall be governed by English Law and the
                  parties irrevocably submit to the non-exclusive jurisdiction
                  of the English Courts provided, however, that the issuance
                  sale, resale or transfer of any of the Consideration Shares
                  shall be governed by the US Federal Securities Laws to the
                  extent applicable.

16.2              The Vendors irrevocably nominate and instruct the Vendors'
                  Solicitors and the Purchaser irrevocably nominates and
                  instructs the Purchaser's Solicitors to receive service of any
                  notice or proceedings required to be served upon or given to
                  them or any of them pursuant to this agreement.


                                       31

<PAGE>

<TABLE>
<CAPTION>

FIRST SCHEDULE
- ----------------------

PART A - THE VENDORS
- ----------------------

COLUMN 1                            COLUMN 2                COLUMN 3              COLUMN 4                 COLUMN 5
- --------                            --------                --------              --------                 --------
Name and address                    Number of Ordinary      Number of Preferred   Consideration Shares     US$ Cash
                                    Shares held             Shares held           to be                    Consideration
                                                                                  issued
<S>                                 <C>                     <C>                   <C>                      <C>
ANTHONY PETER                       4,000                   Nil                   Nil                      3,266,895
FENDICK COOK
63 St Annes Road
Leeds
West Yorkshire
LS6 3NY

KEITH ANTHONY                       2,500                   Nil                   Nil                      2,041,810
HARRINGTON
9 Rochester Grove
Hazelgrove
Stockport
Cheshire
SK7 4JD

JULIAN HAYWARD                      4,500                   Nil                   Nil                      3,675,257
18 Nursery Grove
Alwoodly
Leeds
West Yorkshire
LS17 7AL

GLEN ANTHONY                        5,500                   Nil                   12,454                   3,799,808
HOPKINSON
"Stoneycroft"
27 Croftway
Sherburn-in-Elmet
Leeds
LS25 6BW


                                       32

<PAGE>

COLUMN 1                            COLUMN 2                COLUMN 3              COLUMN 4                 COLUMN 5
- --------                            --------                --------              --------                 --------
PAUL LEON                           3,500                   Nil                   Nil                      2,858,533
MARINUS HOYLE
Holme Farm Cottage
Wothersome
Wetherby
Leeds
West Yorkshire
LS23 6NA

AGNES JULIENNE DIETLINDE            Nil                     3,033                 Nil                      2,477,123
KATRITZKY REVOCABLE TRUST
1221 South West
21 Street
Gainsville
Florida
32601
USA

K B (CI) NOMINEES LTD               Nil                     3,034                 6,688                    2,106,249
West Centre
St Helier
Jersey

UNIVERSITY OF LEEDS INNOVATIONS     Nil                     1,214                 Nil                      991,503
LTD
175 Woodhouse Lane
Leeds
West Yorkshire
LS2 3AR


- ---------------------------------------------------------------------------------------------------------------------
TOTAL                               20,000                  7,281                 19,142                   21,217,178
</TABLE>


                                       33

<PAGE>

<TABLE>
<CAPTION>

PART B  THE OPTIONHOLDERS
- -------------------------

COLUMN 1                             NO. OF SHARES/        COLUMN 2              COLUMN 3          COLUMN 4
- --------                                 OPTIONS           --------              --------          --------
                                     ---------------
Name                                                        2000 Options         2002 Options      $ Cash Value
<S>                                   <C>                   <C>                  <C>               <C>
IAN BUCHAN                            401                   401                  175               470,433
ANTHONY PETER FENDICK                 175                                        150               122,509
COOK*
CHRISTOPHER HARDY                     150                   361                                    294,837
KEITH ANTHONY                         361                                        150               122,509
HARRINGTON*
JULIAN HAYWARD*                       150                                        150               122,509
GLEN ANTHONY                          150                                        150               122,509
HOPKINSON*
PAUL LEON MARINUS                     150                                        150               122,509
HOYLE*
JUDITH MADELEY                        375                                        375               306,271
GARETH OWEN                           361                   361                                    294,837
DANIEL THOMAS                         200                                        200               163,345
ALEC WESTLEY                          150                                        150               122,509
OMARA WILLIAMS                        250                                        250               204,181
- -----------------------------------------------------------------------------------------------------------
TOTAL                                 3023                  1123                 1900              2468,958
</TABLE>


                                       34

<PAGE>

<TABLE>
<CAPTION>

SECOND SCHEDULE
- ---------------

THE COMPANY
- -----------

<S>                                              <C>
Registered number:-                              02708693
Date of Incorporation:-                          22 April 1992

Incorporated under the Companies Acts 1985       1985 and 1989
and 1989

Registered Office:-                              5 North Hill Road
                                                 Headingley
                                                 Leeds
                                                 West Yorkshire
                                                 LS6 2EN

                                                 Authorised Capital:-

Issued Capital:-                                 L27,281 divided into 20,000
                                                 Ordinary Shares
                                                 7,281 Preference Shares

Shareholders:-                                   See First Schedule

Directors:-                                      Anthony Peter Fendick
                                                 Cook
                                                 Robert Kenyon Grantham
                                                 Dr. Keith Anthony Harrington
                                                 Dr. Julian Hayward
                                                 Dr.Glen Anthony Hopkinson
                                                 Dr. Paul Leon Marinus Hoyle
                                                 Dr. Ederyn Williams
                                                 Raymond Wolfson

Secretary:-                                      Keith Anthony Harrington

Accounting Reference Date:-                      31 March

Subsisting Mortgages and Charges:-               Debenture to Fixed and Floating
                                                 Lloyds Bank PLC
                                                 8 December 1997
</TABLE>


                                       35

<PAGE>

THIRD SCHEDULE

THE PROPERTIES



1.    BRIEF DESCRIPTION: LAND AND BUILDINGS KNOWN AS 5 NORTH HILL ROAD
      HEADINGLY SHOWN EDGED RED ON THE ATTACHED PLAN.

2.    TENURE: FREEHOLD

3.    REGISTERED TITLE NUMBER: WYK 401148


                                       36

<PAGE>

FOURTH SCHEDULE

WARRANTIES

GENERAL

1.1               THE VENDORS

1.1.1             The Vendors are the beneficial and legal owners of the Shares
                  as set out in the First Schedule and are entitled to sell the
                  Shares to the Purchaser free from all liens charges and
                  encumbrances without the consent of any third party.

1.1.2             Each of the Vendors has full power and authority to enter into
                  this agreement and the other documents to be executed in
                  connection with it, all of which constitute (or will when
                  executed constitute) legal and valid binding obligations on
                  them enforceable in accordance with their respective terms.

1.1.3             No bankruptcy order has been made in respect of any of the
                  Vendors or a petition for such an order presented.

1.1.4             No application has been made in respect of any of the Vendors
                  for an interim order under section 253 Insolvency Act 1986.

1.1.5             None of the Vendors is unable to pay any debt as that
                  expression is defined in section 268 Insolvency Act 1986.

1.1.6             No person has been appointed by the court to prepare a report
                  in respect of any of the Vendors under section 273 Insolvency
                  Act 1986.

1.1.7             No interim receiver has been appointed of the property of any
                  of the Vendors under section 286 Insolvency Act 1986.


                                       37

<PAGE>

1.1.8             None of the Vendors has ever been disqualified from acting as
                  a director.

1.2               THE SHARES

1.2.1             The Shares will at Completion constitute the whole of the
                  issued and allotted share capital of the Company and are fully
                  paid or credited as fully paid.

1.2.2             There are no options, rights to subscribe for, calls or
                  contracts for the issue of any shares in the Company available
                  to any person and all options outstanding immediately
                  preceding the date of this Agreement have been exercised and
                  the underlying shares issued other than as specified in Part B
                  of the First Schedule.

1.3               ACCURACY OF DISCLOSURE LETTER

                  All statements of fact and information in the Disclosure
                  Letter contained or referred to in the Disclosure Letter are
                  true and not misleading, all documents annexed to the
                  Disclosure Letter are true copies and all statements of
                  opinion in the Disclosure Letter have been made after due and
                  careful enquiry and are reasonably believed to be correct and
                  nothing has been omitted from the Disclosure Letter which
                  renders any of such statements incomplete, inaccurate or
                  misleading.

1.4               LICENCES  TO PURCHASE SHARES

                  All necessary licences, authorisations, orders, grants,
                  consents, permissions and approvals to the purchase of the
                  Shares by the Purchaser have been obtained and remain in full
                  force and effect and there are no circumstances which indicate
                  that any of such licences, authorisations,


                                       38

<PAGE>

                  orders, grants, consents, permissions or approvals may be
                  revoked or not renewed, in whole or in part.

1.5               CONSIDERATION SHARES

1.5.1             Each Vendor understands that the offer and sale of the
                  Consideration Shares being issued pursuant to this agreement
                  has not been registered but that Pharmacopeia will use its
                  best endeavours in the terms set out in Clause 3.8.

1.5.2             Each Vendor acknowledges receipt of and has read, carefully
                  considered and fully understands this agreement and
                  Purchaser's Annual Report on Form 10-K for the year ended 31
                  December 1998, Purchaser's Quarterly Reports on Form 10-Q for
                  the first three quarters ended 30 September 1999 and the
                  Purchaser's Notice of 1999 Annual Meeting and Proxy Statement
                  and all other documents, including exhibits, related to
                  Purchaser and its consolidated operations requested by and
                  furnished to such Vendor (such documents are herein
                  collectively referred to as the "Purchaser Information"). No
                  Vendor has been furnished with or solicited by any offering
                  literature, leaflet, public promotional meeting, circular,
                  newspaper or magazine article, radio or television
                  advertisement, or any other form of general advertising.

1.5.3             Each Vendor is able to (i) bear the economic risk of its
                  investment in the Consideration Shares and (ii) hold the
                  Consideration Shares for an indefinite period of time.


                                       39

<PAGE>

1.5.4             Each Vendor understands the business in which Purchaser is
                  engaged and has such knowledge and experience in financial and
                  business matters that it is capable of evaluating the merits
                  and risks of his investment in the Consideration Shares and of
                  making an informed investment decision with respect thereto.
                  Each Vendor has obtained sufficient information to evaluate
                  the merits and risks of its investment and to make such a
                  decision.

1.5.5             In making its decision to invest in the Consideration Shares,
                  each Vendor has relied upon independent investigations made by
                  it and by its professional advisors. Each Vendor and its
                  advisors have been given the opportunity to obtain information
                  and to examine this agreement and the exhibits hereto and to
                  ask questions of, and to receive answers from, Purchaser or
                  any person acting on its behalf concerning the Consideration
                  Shares, Purchaser and terms and conditions of this investment,
                  and to obtain any additional information to verify the
                  accuracy of any information previously furnished. All such
                  questions have been answered to such Vendor's full
                  satisfaction.

1.5.6             Save as set out in this Agreement, each Vendor confirms that
                  neither Purchaser nor any of its affiliates or agents have
                  made any representations or warranties (oral or written)
                  concerning such Vendor's investment in the Consideration
                  Shares, Purchaser, its business, prospects or anticipated
                  financial results, or other matters.


                                       40

<PAGE>

1.5.7             The Consideration Shares are being purchased solely for such
                  Vendor's own account, as principal, for investment and not for
                  the interest of any other Person or entity and not with a view
                  to, or in connection with, any resale, distribution,
                  subdivision, or fractionalisation of the Consideration Shares.

1.5.8             Each Vendor who receives Consideration Shares understands
                  that:

1.5.8.1           such Vendor must bear the economic risk of the investment for
                  an indefinite period of time because the Consideration Shares
                  cannot be resold unless such sale is subsequently registered
                  under the Securities Act and state securities laws or unless
                  an exemption from such registration is available, as
                  established by an opinion of counsel satisfactory to
                  Purchaser;

1.5.8.2           the certificate(s) evidencing each of the Consideration Shares
                  will bear the following legend:

                  "The Securities represented by this certificate have not been
                  registered under the Securities Act of 1933, as amended (the
                  "Act"), or any state securities or "blue sky" laws, and may
                  not be offered, sold, assigned, transferred, pledged or
                  otherwise disposed of unless registered pursuant to the
                  provisions of such act and blue sky laws or an exemption
                  therefrom is available as established by a written opinion of
                  counsel acceptable to the Company.

1.5.8.3           no federal or state agency has passed on or made any
                  recommendations or endorsements of the investment in the
                  Consideration Shares.


                                       41

<PAGE>

1.5.8.4           each Vendor's investment in Purchaser involves certain risks
                  in that, among other factors, successful operation of
                  Purchaser may depend on factors beyond the control of
                  Purchaser.



THE COMPANY

2.1               THE COMPANY

2.1.1             The Company is a private company limited by shares
                  incorporated in England and the information set out in the
                  second schedule is correct.

2.1.2             The Company's sole business is that of the development,
                  licencing and maintenance of chemical databases, software
                  systems and chemical data content and the provision of
                  consultancy services to support pharmaceutical discovery
                  research and it has never carried on any other business.

2.2               SUBSIDIARIES

                  The Company does not have and never has had any subsidiaries
                  or subsidiary undertakings and nor does the Company control or
                  take part in the management of any other company or business
                  organisation and it has never done so or agreed to do so, and
                  the Company is not, never has been and has not agreed to
                  become the registered holder or beneficial owner of any share
                  or loan capital in any company.

2.3               DIRECTORS

                  The Company does not have any directors, shadow directors or
                  alternate or associate directors other than the persons listed
                  in the second schedule.

2.4               TRADING NAMES ETC


                                       42

<PAGE>

                  The Company uses (and since its incorporation has used) no
                  name other than its corporate name for any purpose.

2.5               AGENTS

2.5.1             No person is authorised to act as agent for the Company or to
                  bind the Company otherwise than the directors of the Company
                  acting as the Board.

2.5.2             There are no powers of attorney given by the Company which are
                  in force.

2.6               OVERSEAS AGENCIES

                  The Company does not have any branch, agency or any permanent
                  establishment outside the United Kingdom.

2.7               SHARE CAPITAL

2.7.1             Since the Balance Sheet Date, no share or convertible
                  securities or options for any such securities of the Company
                  (or any rights or interests therein) have been created,
                  allotted or issued or agreed to be created, allotted or
                  issued.

2.7.2             There are no outstanding rights to call for the creation,
                  allotment, issue, transfer or conversion at any time of any
                  share or loan capital of the Company (or any rights or
                  interests therein).

2.7.3             No shares in the capital of the Company have been issued and
                  no transfer of shares in the capital of the Company has been
                  registered otherwise than in accordance with the Articles of
                  Association of the Company from time to time in force and all
                  such transfers have been duly stamped.

2.8               STATUTORY AND OTHER REGULATIONS


                                       43

<PAGE>

2.8.1             The Company has at all times carried on business and conducted
                  its affairs in all respects in accordance with its Memorandum
                  and Articles of Association for the time being in force.

2.8.2             All licences, authorisations, orders, grants, consents,
                  permissions and approvals necessary to the proper carrying on
                  of the business of the Company have been obtained and:-

2.8.2.1           the Vendors are not aware of any material breach of any of
                  their terms or conditions; and

2.8.2.2           the Company has not received any notice and the Vendors are
                  not aware of any circumstances which indicate that any of them
                  may be revoked or not renewed, in whole or in part.

2.8.3             So far as the Vendors are aware the Company nor any of its
                  officers is not in material breach of or has failed to comply
                  in full with any statutory or municipal rules, regulations and
                  provisions applying to or affecting the business or activities
                  of the Company.

2.8.4             All documents required by the Companies Act or any other
                  legislation to be filed with the Registrar of Companies in
                  respect of the Company have been duly filed and were correct
                  and due compliance has been made with all other legal
                  requirements in connection with the formation of the Company
                  and its conduct and all issues and allotments of shares,
                  debentures and other securities.


                                       44

<PAGE>

2.8.5             So far as the Vendors are aware, there are no investigations
                  or enquiries (pending, threatened or in existence) by or on
                  behalf of any governmental or other body in respect of the
                  affairs of the Company.

2.9               DATA PROTECTION ACT

                  The Company has complied with all material requirements of the
                  Data Protection Act 1984 and in particular:-

2.9.1             has registered as a data user under that Act for all purposes
                  for which registration is required by the business as carried
                  on by the Company;

2.9.2             has complied with the data protection principles; and

2.9.3             the Company has not received any notice letter or complaint
                  alleging a breach by it of the provisions of the Data
                  Protection Act 1984 and has no reason to believe that
                  circumstances exist which may give rise to such a notice
                  letter or complaint.

2.10              STATUTORY BOOKS AND MEMORANDA AND ARTICLES OF ASSOCIATION

2.10.1            The Register of Members and other books required by the
                  Companies Act to be kept by the Company contain an accurate
                  and complete record of the matters with which they should deal
                  and there has been no notice of any proceedings to correct or
                  rectify any such books.

2.10.2            The copy of the Memorandum and Articles of Association of the
                  Company attached to the Disclosure Letter is complete and
                  accurate in all respects and has embodied in it or annexed to
                  it a copy of every such resolution and agreement as is
                  referred to in section 380 of the Companies Act.


                                       45

<PAGE>

2.11              RESOLUTIONS

                  No resolutions of any kind of the Company or any class of its
                  members (other than those relating to business at an Annual
                  General Meeting which is not special business) have ever been
                  passed.

2.12              INSOLVENCY

2.12.1            The Company has never been a party to any transaction to which
                  the provisions of sections 238 to 246 (inclusive) of the
                  Insolvency Act 1986 may be applicable.

2.12.2            No order has been made or petition presented or resolution
                  passed for the winding up or administration of the Company, no
                  receiver or administrator or administrative receiver has been
                  appointed or could lawfully be appointed by any person of the
                  Company's business or assets or any part thereof, the Company
                  is not insolvent and has not stopped payment and is not unable
                  to pay its debts (within the meaning of section 123 of the
                  Insolvency Act 1986) and the Company is capable of meeting its
                  liabilities as and when they fall due and for the foreseeable
                  future.

2.13              PURCHASE OF SHARES

2.13.1            No person is entitled to receive from the Company any fees,
                  brokerages or other commissions in connection with the
                  purchase or sale of shares in the Company.

2.13.2            The Company has not at any time acted in breach of section 151
                  of the Companies Act and nor has it ever given financial
                  assistance in connection


                                       46

<PAGE>

                  with the acquisition of its own or any holding company's
                  shares in accordance with the provisions of section 155 of the
                  Companies Act.

2.13.3            The Company has never reduced, purchased or redeemed its share
                  capital or agreed to do so.

2.14              REGISTRATION OF CHARGES

                  All charges in favour of the Company have (if appropriate)
                  been registered in accordance with the Companies Act.

2.15              POSSESSION OF DOCUMENTS

                  All title deeds relating to the assets of the Company and an
                  executed copy of all agreements to which Company is a party
                  and the original copies of all other documents which are owned
                  by, or which ought to be in the possession of, the Company are
                  in its possession.

2.16              SEAL

                  The Company has a common seal.

2.17              FINANCIAL SERVICES ACT

                  The Company does not carry on or purport to carry on in the
                  United Kingdom any investment business within the meaning of
                  the Financial Services Act 1986.

3.                THE ACCOUNTS
- ------------------------------
3.1               THE ACCOUNTS

                  The Accounts:-

3.1.1             have been prepared in accordance with the historical cost
                  convention;


                                       47

<PAGE>

3.1.2             comply with the requirements of the Companies Act, all other
                  relevant statutes, all relevant SSAP's, all pronouncements
                  issued or adopted by the Accounting Standards Board and other
                  generally accepted accounting principles ("GAAP") applicable
                  to a United Kingdom company and have been audited in
                  accordance with the Auditing Standards issued by the Auditing
                  Practices Board;

3.1.3             have been prepared on the same bases and policies of
                  accounting as the published statutory accounts of the Company
                  for the preceding three accounting reference periods (and in
                  particular there has been no change in any practice or policy
                  or in any methods or bases of valuation or any accountancy
                  treatment relating to the keeping of any such accounts);

3.1.4             give a true and fair view of the state of affairs of the
                  Company at the Balance Sheet Date and of its profit or loss
                  for the financial period ended on the Balance Sheet Date;

3.1.5             disclose all the assets and liabilities of the Company as at
                  the Balance Sheet Date;

3.1.6             contain proper provision or reserves or appropriate notes in
                  respect of all liabilities (whether actual or contingent,
                  quantified or disputed) of the Company as at the Balance Sheet
                  Date;

3.1.7             contain proper provision or reserves for Taxation assessed or
                  liable to be assessed on the Company or for which it is or may
                  become liable up to the Balance Sheet Date and any liability
                  to pay Taxation which has been deferred for any reason;


                                       48

<PAGE>

3.1.8             contain proper provision for depreciation and for any
                  obsolescence of assets (all rates of depreciation being
                  consistent over the three financial years preceding the
                  Balance Sheet Date) and the policy of depreciation has been
                  applied in accordance with SSAP 12;

3.1.9             contain proper and adequate provision or reserves for any
                  foreseeable losses which may arise on completion and/or on
                  realisation of stock or work-in-progress (the method and bases
                  of valuing of which have been accepted by the Revenue); and
                  the value attributed to the remaining stock and the raw
                  materials included in work in progress and finished stock did
                  not exceed the lower of cost and net realisable value as at
                  the Balance Sheet Date;

3.1.10            fully disclose all capital and leasing commitments of the
                  Company; and

3.1.11            are not affected by any extraordinary or non-recurring items.

3.2               PAST ACCOUNTS

                  The published statutory accounts of the Company for the three
                  accounting reference periods preceding the period to which the
                  Accounts relate comply with the same criteria as described in
                  relation to the Accounts in paragraph 3.1 in relation to the
                  periods in respect of which and the date to which they were
                  each prepared.

3.3               BOOK DEBTS SHOWN IN THE ACCOUNTS

                  The debts shown in the Accounts (less the amount of any
                  provision or reserve in the Accounts calculated on the same
                  basis as that applied in the published statutory accounts of
                  the Company for the preceding three


                                       49

<PAGE>

                  accounting reference periods) were good and collectable in
                  full in the ordinary and normal course of business and have
                  realised the net amount thereof and none of those debts:-

3.3.1             was at the Balance Sheet Date subject to any counter-claim or
                  set off (except to the extent of any such provision or
                  reserve); or

3.3.2             has subsequently been released on terms that any debtor pays
                  less than the full book value of his debt or has been written
                  off or has proved to any extent irrecoverable or is now
                  regarded as irrecoverable (in whole or in part).

3.4               ACCOUNTING RECORDS

                  All accounts, books, ledgers, financial and other records of
                  whatsoever kind of the Company are in the possession of the
                  Company have been properly kept in accordance with good
                  business practice and completed in accordance with generally
                  accepted accounting principles and standards and statutory
                  requirements, and disclose with reasonable accuracy the
                  current financial and contractual position of the Company and
                  contain a record of its assets and liabilities.

3.5               MANAGEMENT ACCOUNTS

                  The Management Accounts for the period from the Balance Sheet
                  Date to 31 January 2000 a copy of which is annexed to the
                  Disclosure Letter have been prepared by the Company with due
                  care and attention in accordance with the same accounting
                  policies as the Accounts and show a reasonably accurate and
                  fair view of the state of affairs and profit or loss of the



                                       50

<PAGE>

                  Company as at the date and for the period in respect of which
                  they have been prepared and are not affected by any
                  exceptional or non-recurring items; but it is hereby
                  acknowledged that they have not been prepared on a statutory
                  basis nor have they been audited and nor do they address
                  taxation arising on profits of the Company for the current
                  accounting period.

4.                THE PROPERTIES
- --------------------------------
4.1               The Property comprises all the properties owned, occupied or
                  otherwise used in connection with their business by the
                  Company.

4.2               The information supplied by the Company on which the
                  Certificates of Title is based is true, complete and accurate
                  in all respects and is not misleading.

4.3               The Certificate of Title provided on behalf of the Vendors is
                  true, complete and accurate in all respects and not
                  misleading.

5.                FIXED AND CURRENT ASSETS

5.1               OWNERSHIP OF ASSETS

                  The Company is the sole owner with good and marketable title
                  free from all liens, charges, encumbrances, options or adverse
                  claims (including any hiring, licensing or rental agreements
                  or reservations of title) of all the assets included in the
                  Accounts or acquired after the Balance Sheet Date which it
                  owns or reputedly owns (subject to sales of current assets in
                  the ordinary and normal course of its trading) or which are
                  now in its possession or under its control or which it uses in
                  its business and the


                                       51

<PAGE>

                  Company has not agreed to create or grant any lien, charge,
                  option or other encumbrance over such assets.

5.2               ASSETS USED IN THE BUSINESS

5.2.1             The assets owned by the Company together with any assets held
                  under any hire or hire purchase rental or leasing agreement
                  (the material details of which are contained in the Disclosure
                  Letter) comprise all the assets necessary for the continuation
                  of the Company's business as now carried on.

5.2.2             The Company does not use and there is no necessity for it to
                  use in the course of its business any asset which belongs to
                  or is hired, leased or licenced to or is otherwise in the
                  possession or under the control of the Vendors (or any of
                  them) or any of their Associates.

5.3               PLANT AND MACHINERY

5.3.1             The plant, machinery, vehicles and other equipment owned by or
                  used in connection with the business of the Company ("PLANT
                  AND MACHINERY"):-

5.3.1.1           are in a good and safe state of repair and condition, having
                  regard to its age and usage;

5.3.1.2           are in the possession and (save for those items the subject of
                  the hire, hire purchase, rental or leasing agreements listed
                  in the Disclosure Letter) control of the Company; and

5.3.2             The plant registers of the Company comprise a complete and
                  accurate record of all the Plant and Machinery.


                                       52

<PAGE>

5.3.3             Maintenance contracts are in full force and effect in respect
                  of all Plant and Machinery which is of a kind which is normal
                  or prudent to have maintained by independent or specialist
                  contractors;

5.4               COMPUTER EQUIPMENT AND SOFTWARE

5.4.1             The Company has in force maintenance contracts for all items
                  of computer hardware (including operating systems) and
                  software support contracts for all items of software which it
                  uses and there is no reason to believe that these maintenance
                  and support contracts will not be renewed by the other
                  contracting party upon their expiry (if so required by the
                  Company) upon substantially similar terms to those now
                  applicable.

5.4.2             The Company did not suffer any failures or breakdowns of or
                  bugs in the computer hardware or software which it now uses
                  during the year preceding the date of this agreement which had
                  a material effect on the business of the Company.

5.4.3             The Company has operated and used all items of computer
                  hardware used by it in accordance with the manufacturers
                  recommendations including (without limitation) any
                  recommendations as to environmental conditions and power
                  supply.

5.5               COMPUTER SOFTWARE

5.5.1             In this paragraph and paragraphs 5.6 and 5.7:-

                  "SOFTWARE" means the computer software owned by the Company
                  listed in the Disclosure Letter including all programs and
                  data in such software and all manuals and operator guides
                  relating to such software;


                                       53

<PAGE>

                  "THIRD PARTY SOFTWARE" means the computer software licensed to
                  the Company listed in the Disclosure Letter (each a "Software
                  Licence") including all programs and data in such software and
                  all manuals and operator guides relating to such software; and

                  "SOURCE CODES" means the source codes which are included in or
                  relate to the Software and the source codes which are included
                  in or relate to the Third Party Software in each case
                  deposited on magnetic media, all information in human readable
                  form necessary to enable a reasonably skilled programmer or
                  analyst to maintain or enhance the Software and the Third
                  Party Software without the assistance of any other person or
                  reference to any other materials, including, all maintenance
                  tools (test programs and program specifications), proprietary
                  or third party system utilities (compiler and assembler
                  descriptions), a description of the system/program generation
                  and all comments, logic manuals and flow charts made by
                  developers of such source codes which relate to such source
                  codes.

5.5.2             The Software and the Third Party Software is all the computer
                  software owned, used, required or supplied by the Company in
                  connection with its business.

5.5.3             The Company has in force software support contracts for all
                  items of Third Party Software, the terms of which have been
                  disclosed in the Disclosure Letter and there is no reason to
                  believe that these software support contracts will not be
                  renewed by the other contracting party upon


                                       54

<PAGE>

                  their expiry (if so required by the Company) upon
                  substantially similar terms to those now applicable.

5.5.4             The Company did not suffer any failures or bugs in or
                  breakdowns of the Software or the Third Party Software during
                  the year preceding the date of this agreement which has had a
                  material effect on the business of the Company or which
                  otherwise has had a material and continuing effect on the
                  Software or Third Party Software.

5.5.5             None of the Company's employees or independent contractors
                  involved in the development of the Software were, during the
                  period of such development, under any obligation to any third
                  party (whether in relation to any previous service contract or
                  contract for services or otherwise) which would or might have
                  an adverse effect on the Company's claim to ownership of the
                  Software or the Source Codes of the Software.

5.5.6             The Company has complied in all material respects with all its
                  obligations pursuant to any arrangements which require the
                  Company to develop or supply any of the Software or the Third
                  Party Software. In particular, any Software or Third Party
                  Software so developed or supplied conforms in all material
                  respects to the specifications contained or referred to in the
                  relevant arrangement and is fully capable of performing all
                  tasks and functions for which it has been developed or
                  supplied.

5.5.7             The Company has used all reasonable care and skill in the
                  development of the Software and has carried out reasonable
                  investigations and taken all other steps which may be
                  reasonable so as to ensure that any Third Party


                                       55

<PAGE>

                  Software which the Company supplies with or for use in
                  conjunction with any of the Software is capable of being used
                  for the particular tasks and functions for which it is
                  supplied.

5.5.8             All manuals and operator guides relating to the Software and
                  the Third Party Software are sufficient to enable the
                  Purchaser to make full, proper and efficient use of the
                  Software and the Third Party Software.

5.5.9             The Company owns and is in possession of up to date and
                  accurate copies of the Source Codes of the Software. The
                  Company is either in possession of up to date and accurate
                  copies of the Source Codes of the Third Party Software or has
                  in force escrow agreements in respect of such Source Codes the
                  terms of which have been fully disclosed in the Disclosure
                  Letter and such agreements are enforceable by the Company in
                  accordance with their terms and there has not been any default
                  (or any Event which with notice or lapse of time or both would
                  constitute a default) under any of them by the Company or by
                  any party to such agreements.

5.5.10            The Software Licences authorise the Company to use the
                  computer software that is not owned by the Company in the ways
                  in which they are in fact used or are required to be used in
                  connection with the business of the Company as it is now
                  carried on.

5.5.11            The Software Licences are enforceable by the Company in
                  accordance with their terms and there has not been any default
                  (or any Event which with notice or lapse of time or both would
                  constitute a default) under any of them by the Company or by
                  any other party to such Software Licences.


                                       56

<PAGE>

5.5.12            No licence of Software by the Company contains any obligation
                  other than the provision of support for the Software licensed.

5.6               INTEGRITY OF COMPUTER SYSTEMS

5.6.1             The Company has taken proper precautions to preserve the
                  availability confidentiality and integrity of its computer
                  systems and has had such systems reviewed on a regular basis
                  by independent experts in the field.

5.6.2             All computer software (including all programs and data in such
                  software) used by the Company is reliable and readable. All
                  media on which such software is stored are in good readable
                  condition and contain no programs or data which are either
                  intended to or which may have the effect of modifying,
                  deleting or otherwise impairing such software (or any of the
                  programs or data in such software) or any other programs or
                  data which are either intended to or which may have the effect
                  of impairing any computer hardware.

5.6.3             The Vendors are not aware of any case where unauthorised
                  access to the Company's computer systems has taken place, or
                  where any of the software or data in those computer systems
                  has been modified without the Company's express authority or
                  where fraud has been committed against the Company by use or
                  abuse of its computer systems whether alone or in conjunction
                  with any third party.

5.6.4             No event has occurred which indicates the Company's computer
                  systems have been adversely affected by the advent of the year
                  2000 and so far as the Vendors are aware the Company's
                  computer systems are fully


                                       57

<PAGE>

                  "millennium compliant". For the purposes of this warranty,
                  "millennium compliant" means that neither performance nor
                  functionality is or will be affected by dates prior to, during
                  or after the year 2000.

5.7               LEASED ASSETS

                  No circumstance has arisen or is likely to arise in relation
                  to any asset held by the Company, under a lease or similar
                  agreement, whereby the rental payable has been, or is likely
                  to be, increased and, in particular, all such assets have at
                  all relevant times been used for a qualifying purpose for the
                  purposes of sections 39, 40 and 42 Capital Allowances Act
                  1990.

5.8               BOOK DEBTS

5.8.1             None of the debts which are due to the Company at the date of
                  this agreement and which shall have arisen after the Balance
                  Sheet Date are now or have at any time been overdue by more
                  than [twelve] weeks nor have any of those debts been written
                  off or to the knowledge of the Vendors will prove to be
                  irrecoverable to any extent.

5.8.2             So far as the Vendors are aware the full amount of all debts
                  which shall be owing to the Company at Completion (whenever
                  arising) will be recovered in full free of any counter-claim
                  or set off (less the amount of any provision or reserve which
                  has been calculated on the same basis as that applied in the
                  Accounts or disclosed in the Disclosure Letter) in the
                  ordinary and normal course of business and in any event not
                  later than twelve weeks after Completion.


                                       58

<PAGE>

5.8.3             So far as the Vendors are aware since the Balance Sheet Date
                  no other obligations due to the Company have been written off
                  or written down or have proved to be irrecoverable in whole or
                  in part or are now regarded as irrecoverable nor has there
                  been any agreement for the release of any person under any
                  liability to the Company.

INTELLECTUAL PROPERTY



6.1               DEFINITIONS

                  In this Part 6:-

                  "INTELLECTUAL PROPERTY RIGHTS" includes patents, trade marks,
                  service marks, registered designs, design rights,
                  semi-conductor, topography rights, copyrights, database
                  rights, know-how, get up, confidential information, business
                  names, internet domain names and any other similar protected
                  rights in any country together with pending applications for
                  registration or recording thereof;

                  "LICENSED RIGHTS" means the Intellectual Property Rights not
                  owned by the Company but used or required by the Company in
                  connection with its businesses including the Intellectual
                  Property Rights in the Third Party Software and the Source
                  Codes of the Third Party Software;

                  "SOFTWARE", "THIRD PARTY SOFTWARE" and "SOURCE CODES" shall
                  bear the same meanings given to those expressions in paragraph
                  5.5.

6.2.1             Full details of the Licensed Rights have been disclosed in the
                  Disclosure Letter to the Purchaser. The Company has a licence
                  to use the Licensed Rights. All such licences are in full
                  force and effect, the terms of such licences have been fully
                  disclosed in the Disclosure Letter and such


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                  licences are enforceable by the Company in accordance with the
                  terms and there has not been any default (or any Event which
                  with notice or lapse of time or both would constitute a
                  default) under any of them by the Company or by any other
                  party to such licences.

6.2.2             The Company is the sole beneficial owner the Intellectual
                  Property Rights in the Software and the Source Codes of the
                  Software, free from liens, charges and encumbrances, each of
                  such Rights is valid and enforceable and none of them is being
                  claimed, opposed or attacked by any other person.

6.2.3             All formulae, processes and other information forming part of
                  the Licensed Rights (including know-how and confidential
                  information) are adequately documented and to the extent that
                  they are confidential or material to the business of the
                  Company have not been (and nor is there any agreement that
                  they will be) disclosed to any third party.

6.2.4             All documents material to the originals of all licences to the
                  Licensed Rights are in the possession of the Company.

6.3               NO INFRINGEMENTS

                  The business of the Company (and of any licensee under a
                  licence granted by the Company) as now carried on does not and
                  is not likely to infringe any Intellectual Property Rights of
                  any other person or give rise to a liability to pay
                  compensation pursuant to sections 40 and 41 Patents Act 1977.

6.4               NO RIGHTS GRANTED BY THE COMPANY


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<PAGE>

6.4.1             No right has been granted by or on behalf of the Company or
                  any of the Vendors to any person to do any thing which would
                  or might otherwise infringe the Licensed Rights and no act has
                  been done or omission occurred whereby they or any of them
                  have ceased or might cease to be valid and enforceable.

6.4.2             No right has been granted by or on behalf of the Company or
                  any of the Vendors to any person to do any thing which would
                  or might otherwise infringe the Intellectual Property Rights
                  in the Software otherwise by way of a non-exclusive licence to
                  use the Software granted on a commercial basis in the ordinary
                  course of the business of the Company.

6.4.3             The terms of any licence granted by or on behalf of the
                  Company or any of the Vendors to use the Software have been
                  fully disclosed in the Disclosure Letter and such licences are
                  enforceable by the Company in accordance with their terms and
                  there has not been any default (or any Event which with notice
                  or lapse of time or both would constitute a default) under any
                  of them by the Company or by any other party to such licences.

6.4.4             Every copy of the Software supplied pursuant to the licences
                  referred to in paragraph 6.4.3 has included appropriate
                  copyright notices and effective protection against copying and
                  against access to the Source Codes of the Software.

6.4.5             No right has been granted by or on behalf of the Company or
                  any of the Vendors to any person to do any thing which would
                  or might otherwise


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                  infringe the Intellectual Property Rights in the Source Codes
                  of the Software and no act has done or omission occurred
                  whereby they or any of them have ceased or might cease to be
                  valid and enforceable.

FINANCIAL POSITION



7.1               EVENTS SINCE THE BALANCE SHEET DATE

                  Since the Balance Sheet Date:-



7.1.1             there has been no adverse change in the financial or trading
                  position of the Company;

7.1.2             the business of the Company has been carried on in the
                  ordinary and normal course, without any interruption and
                  without any alteration in its nature, conduct, scale, scope or
                  manner and no unusual or abnormal contract differing from the
                  ordinary contracts necessitated by the nature of its business
                  has been entered into by the Company;

7.1.3             there has been no change in:-

7.1.3.1           the manner or time of payment of creditors or the issue of
                  invoices or collection of debts; or

7.1.3.2           the policy of reserving for debtors;

7.1.4             no substantial supplier or customer of the Company (being a
                  supplier who, during the period covered by the Accounts
                  supplied more than 5% of the invoice value of all of the
                  Company's purchases or a customer who during the period
                  covered by the Accounts purchased more than 5% of the invoice
                  value of all of the Company's sales) has ceased or
                  substantially reduced its trade with the Company;


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7.1.5             no asset has been acquired or disposed of or has been agreed
                  to be acquired or disposed of (save for assets acquired or
                  disposed of in the ordinary and normal course of business on
                  arm's length terms) and no contract involving expenditure by
                  it on capital account has been entered into by the Company;

7.1.6             the Company has not paid or become liable to pay any
                  management, service or other such charges to the Vendors or to
                  any person with whom the Vendors are connected (within the
                  meaning of section 839 Taxes Act) other than in respect of
                  goods and services supplied in the ordinary and normal course
                  of business on commercial terms;

7.1.7             the Company has neither disbursed nor received any cash except
                  in the ordinary and normal course of its business and all
                  amounts received by or on behalf of the Company have been
                  deposited with its bankers and appear in the appropriate books
                  of account;

7.1.8             the Company has not declared, paid or made any dividends or
                  other distributions within the meaning of the Taxes Act;

7.1.9             the Company has not made any loans or incurred any borrowings
                  except in the ordinary and normal course of its business; and

7.1.10            the accounting reference period of the Company has not ended
                  or been extended.

7.2               AMOUNTS DUE TO CREDITORS

7.2.1             The amounts now due by the Company to its creditors do not
                  exceed L750,000.


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7.2.2             The aged creditor analysis annexed to the Disclosure Letter
                  accurately shows the amounts owed by the Company to its trade
                  creditors as at 31 January 2000 and the dates of the invoices
                  pursuant to which such debts shall be due.

7.2.3             There are no sums due by, or liabilities or obligations of,
                  the Company to any of the Vendors or the Vendors' associates
                  or affiliates.

7.4               BANK AND OTHER BORROWINGS

7.4.1             Full details of all limits on the Company's bank overdraft and
                  other borrowing facilities together with true, complete and
                  accurate copies of all letters of credit, guarantees and other
                  financial instruments issued on behalf of or for the benefit
                  of the Company and which remain in force are contained in the
                  Disclosure Letter.

7.4.2             The total amount borrowed by the Company does not exceed any
                  limitation on its borrowing contained in its Memorandum or
                  Articles of Association or in any other document which it is a
                  party and the amount borrowed from its bankers does not exceed
                  its overdraft facilities (if any).

7.4.3             No overdraft or other financial facilities of the Company are
                  dependent upon a guarantee of, or a security provided by, the
                  Vendors or any third party.

7.4.4            The Company does not have outstanding and has not agreed to
                 create or issue any loan capital; nor has it factored or
                 discounted any of its debts (or agreed to do so), or been
                 engaged in financing of a type which would not require to be
                 shown or reflected in the Accounts; or borrowed any money


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<PAGE>

                  which it has not repaid (save for borrowings not exceeding the
                  amounts shown in the Accounts).

7.4.5             The Company has not since the Balance Sheet Date, repaid, or
                  become liable to repay, any loan or indebtedness in advance of
                  its stated maturity.

7.4.6             Neither the acquisition of the Shares by the Purchaser nor the
                  compliance of any terms of this agreement will entitle (and no
                  other Event has occurred which would entitle) any third party
                  (with or without the giving of notice) to call for the
                  repayment of any indebtedness of the Company prior to its
                  normal maturity date.

TAXATION



8.1               DEFINITIONS

                  In this Part 8:

                  "ACT" means advance corporation tax;

                  "CAA" means the Capital Allowances Act 1990;

                  "IHTA" means the Inheritance Tax Act 1984;

                  "TCGA" means the Taxation of Chargeable Gains Act 1992;

                  "TMA" means the Taxes Management Act 1970;

                  "VAT" means value added tax;

                  "VATA" means the Value Added Tax Act 1994.

8.2               GENERAL

8.2.1             All returns, amended returns, computations and payments which
                  should be or should have been made by the Company for any
                  fiscal purpose have been prepared on a proper basis and
                  submitted within the prescribed time limits and are up to date
                  and correct and none of them is now the subject


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<PAGE>

                  or likely to be the subject of any dispute with the Inland
                  Revenue or HM Customs and Excise or other authority concerned
                  and will not give rise to any disallowance of relief,
                  forfeiture, loss of allowance or credit, assessment,
                  adjustment or set off (including any claim for interest on
                  unpaid Taxation) by the Revenue.

8.2.2             All particulars furnished to the Revenue in connection with
                  the application for any consent or clearance on behalf of the
                  Company accurately disclosed all facts and circumstances
                  material to the decision of the Revenue, any such consent or
                  clearance is valid and effective and any such transaction for
                  which such consent or clearance has previously been obtained
                  has been carried into effect only in accordance with the terms
                  of the relevant application and consent for clearance.

8.2.3             The Company is not the subject of a back duty investigation or
                  in-depth enquiry by any fiscal authority and there are no
                  known facts which may give rise to the same.

8.2.4             All income tax under the PAYE system and payments due in
                  respect of employees' contributions to national insurance and
                  graduated state pension have been properly deducted by the
                  Company and (together with any employer's contribution) have
                  been fully and correctly paid to the appropriate authority and
                  proper records thereof have been maintained.

8.2.5             All Taxation required to be deducted from any payments made by
                  the Company which it is obliged or entitled to make has been
                  deducted and accounted in full to the appropriate authority.


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<PAGE>

8.2.6             The Company has never been requested to furnish information
                  pursuant to notices served under section 745 or 778 Taxes Act.

8.2.7             No transactions have been undertaken falling within sections
                  765 or 765A Taxes Act.

8.2.8             The Company is not and has at no time been an investment
                  company, a close investment company or an investment trust
                  company for Taxation purposes.

8.2.9             The Company has not since the Balance Sheet Date taken any
                  action which has had, or might have, the result of altering or
                  prejudicing or in any way disturbing any arrangement or
                  agreement which it has previously negotiated with the Revenue.

8.2.10            The Taxation computations for all accounting periods of the
                  Company ended on or before the last accounts date to which tax
                  computations have been agreed with the Revenue or if not known
                  the last accounts date of the Company, have been agreed with
                  the Revenue.

8.2.11            The Company is and has always been resident only in the United
                  Kingdom for Taxation purposes and has never carried on any
                  trade, business or other activities outside the United Kingdom
                  other than the export of its goods and/or services in the
                  ordinary and normal course of its business.

8.3               TAXABLE PROFITS



8.3.1             The Company has not directly or indirectly paid any
                  remuneration, emoluments or compensation for loss of office or
                  made any gratuitous payment or transferred any assets to any
                  of its present or former directors


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<PAGE>

                  or employees, the cost of which will not be deductible for
                  Taxation purposes.

8.3.2             The Company has not made and is under no obligation pursuant
                  to which it is or at any time may become liable to make any
                  payment of interest, annuity or other annual payment such as
                  may be disallowed as a deduction as a set-off or as a charge
                  on income or otherwise be unrelieved for corporation tax
                  purposes whether by virtue of section 125 or section 787 Taxes
                  Act or otherwise.

8.3.3             No transactions or arrangements involving the Company have
                  taken place or are in existence such that the provisions of
                  section 770 Taxes Act could be or have been applied.

8.3.4             There have been no Events or circumstances such that sections
                  343 or 768 Taxes Act have been or could be applied.

8.4               CAPITAL ASSETS

8.4.1             Save as provided for in the Accounts the values attributed to
                  each of the assets of the Company as at the Balance Sheet Date
                  is such that on any disposal of any of those assets which is
                  treated for Taxation purposes as being for a consideration
                  equal to such value (ignoring any reliefs and allowances
                  available to the Company other than amounts falling to be
                  deducted under section 38 TCGA) no chargeable gain or
                  allowable loss would arise.


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<PAGE>

8.4.2             Since the Balance Sheet Date no asset has been acquired
                  otherwise than by way of a bargain made at arm's length and
                  for a consideration equal to its market value.

8.4.3             The Company is not subject to any contingent liability as is
                  mentioned in section 49 TCGA.

8.4.4             The Company has not effected or been a party to any demerger
                  such as is mentioned in sections 213 to 218 Taxes Act.

[8.4.5            The Company has never made a claim pursuant to sections 23 or
                  24 TCGA.

8.4.6             The Company has never been a party to a transaction falling
                  within section 17 TCGA.

8.4.7             The Company has not received any asset by way of gift as
                  mentioned in section 282 TCGA.

8.4.8             The Company does not own any shares or securities acquired as
                  a "new holding" under the provisions of sections 126 to 130
                  TCGA.

8.4.9             Neither the Company nor any company which was a member of the
                  same group of companies at the relevant time has made any
                  claim under sections 152, 153 or 247 TCGA.

8.4.10            The Company has not been a party to or involved in any share
                  for share exchange nor any scheme of reconstruction or
                  amalgamation such as are mentioned in sections 135 and 136
                  TCGA.

8.4.11            The Company has not been a party to any depreciatory
                  transactions within the meaning of sections 176 and 177 TCGA.


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<PAGE>

8.4.12            The Company has not been subject to any claim or election
                  under section 35 or Schedule 4 TCGA, whether made by itself or
                  any other person.

8.4.13            The Company has never made an election under paragraph 4 of
                  Schedule 2 TCGA.

8.4.14            The Company will not be subject to corporation tax on the
                  disposal of any debt owing to the Company.

8.4.15            Each and every loan made by the Company is a "qualifying loan"
                  for the purpose of section 253 TCGA.

8.4.16            The Company is not entitled to any loss to which section 18
                  TCGA applies.

8.4.17            The Company does not own and has not owned and has never
                  issued any relevant discounted securities or qualifying
                  corporate bonds (as defined in Schedule 13 Finance Act 1996 or
                  section 117 TCGA respectively).

8.4.18            The Company has sufficient information contained in its
                  records to calculate any chargeable gain or allowable loss
                  which may arise as the result of the disposal of assets owned
                  by the Company at the Balance Sheet Date.

8.5               CAPITAL ALLOWANCES

8.5.1             The book value of each of the assets of the Company in or
                  adopted for the purposes of the Accounts on which capital
                  allowances are calculated separately does not exceed the
                  written down value of such asset for the purposes of the CAA
                  and the aggregate book value of plant and machinery for which
                  capital allowances have been claimed under Part II of that Act


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<PAGE>

                  does not exceed the written down value of the qualifying
                  expenditure under that Act.

8.5.2             The Company has not been a party to or involved in any
                  transaction whereby a balancing allowance would be denied or
                  reduced by virtue of section 5 CAA.

8.5.3             No allowances have been claimed by the Company which are
                  liable to be reduced or withdrawn by virtue of sections 1(6),
                  42 or 47 CAA.

8.5.4             No capital expenditure has been incurred which is subject to
                  the provisions of section 75 CAA.

8.6               GROUP ARRANGEMENTS

8.6.1             The Company has never been a member of any group of companies
                  for any Taxation purpose.

8.6.2             The Company has not ceased to be a member of a group of
                  companies for the purposes of sections 178 and 179 TCGA and
                  will not cease to be a member of such a group as a result of
                  Completion.

8.6.3             The Company has not at any time within the period of six years
                  ending with the date of this agreement, acquired any assets
                  other than trading stock from any company which, at the time
                  of the acquisition, was a member of the same group (as defined
                  in section 170 TCGA) as the Company.

8.6.4             The Disclosure Letter sets out full details of any surrender
                  or agreement to surrender, or acceptance or agreement to
                  accept the surrender, by the Company of any amount by way of
                  group relief under the provisions of sections 402, 403 and 407
                  to 413 Taxes Act.


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<PAGE>

8.6.5             All claims for group relief made by the Company were valid and
                  have been or will be allowed by way of relief from corporation
                  tax and the Company is not and will not, as a result of
                  anything done before the date of this agreement, become liable
                  to make any payment for an amount surrendered by any other
                  company under or in connection in with the provisions of
                  section 402 Taxes Act.

8.6.6             The Company is not and has not at any time been party to any
                  arrangement falling within section 410 Taxes Act.

8.6.7             The Company has not made or purported to make any election
                  under section 247 Taxes Act.

8.6.8             The Company has not made nor received nor purported to make or
                  receive any surrender of the benefit of ACT under section 240
                  Taxes Act.

8.6.9             The Company is not liable to be assessed to any Taxation under
                  the provisions of section 190 TCGA.

8.7               DISTRIBUTIONS AND ADVANCE CORPORATION TAX

8.7.1             The Company has not at any time done anything which could be
                  treated as a distribution for the purposes of sections 209 or
                  210 Taxes Act.

8.7.2             No Event or series of Events has occurred which might cause
                  the disallowance of the carry forward of losses or excess
                  charges or such that any of sections 245 or 245A or 245B Taxes
                  Act have applied or could apply.

8.7.3             The Company has not issued any share capital to which the
                  provisions of section 249 Taxes Act or section 141 TCGA could
                  apply nor does it own


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<PAGE>

                  any such share capital nor granted options or rights to any
                  person which entitles that person to require the issue of any
                  share capital.

8.7.4             The Company will be entitled in respect of any qualifying
                  distribution made by it to a full set off of its corresponding
                  payment of ACT under section 239(1) Taxes Act or in so far as
                  there is no set off under section 239(1) or in so far as any
                  set off is restricted under section 239(3).

8.7.5             The Company has not received a capital distribution to which
                  the provisions of section 189 TCGA could apply.

8.7.6             The Company has not made or received any distribution which is
                  an exempt distribution within sections 213 to 218(I)
                  (inclusive) Taxes Act.

8.8               STAMP DUTY

8.8.1             All instruments (other than those which have ceased to have a
                  legal effect) executed by the Company (and which are or were
                  subject to stamp duty) have been duly stamped and the Company
                  has not executed any other instrument relating to any property
                  situate in, or to any matter or thing done or to be done in,
                  any part of the United Kingdom.

8.8.2             The Company has no liability to stamp duty reserve tax.

8.8.3             No relief or exemption has been obtained from stamp duty under
                  section 42 Finance Act 1930 or sections 75-79 (inclusive)
                  Finance Act 1986.

8.9               ANTI-AVOIDANCE

8.9.1             The Company has not entered into or been a party to any
                  pre-ordained series of transactions, composite transactions or
                  any other schemes or arrangements into which steps were
                  inserted which served no purpose other than the saving of
                  Taxation.



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<PAGE>

8.9.2             The Company has not been party to any other transaction or
                  arrangement of any nature which could give rise to a charge to
                  Taxation under Part XVII Taxes Act.

8.10              CLOSE COMPANY

8.10.1            The Company has never been a close company for the purposes of
                  the Taxes Act.

8.10.2            The Company has no loan outstanding to which the provisions of
                  sections 419 and 420 Taxes Act would apply.

8.10.3            The Company has not held and does not hold shares in a company
                  not being another member of a group of companies (including
                  the Company) as defined in section 170 TCGA which has made any
                  such transfer as was referred to in section 125 TCGA.

8.10.4            The Company is not liable to be assessed to inheritance tax by
                  virtue of section 202 IHTA.

8.10.5            There is no potential liability or any unsatisfied liability
                  to inheritance tax attached or attributable to the shares in
                  or to any assets of the Company such that they are or may
                  hereafter become subject to an Inland Revenue charge as
                  mentioned in section 237 and 238 IHTA.

8.10.6            No liability to inheritance tax attributable to the shares in
                  or to any assets of the Company is being settled by
                  installments.

8.10.7            The Company is not entitled to any interest in possession in
                  settled property.

8.10.8            No person is actually or potentially liable to inheritance tax
                  attributable to the value of any of the shares and in
                  consequence no person has or may


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<PAGE>

                  acquire the power to raise the amount of such tax by sale or
                  mortgage of or by a terminal charge on any of the shares as
                  mentioned in section 212 IHTA.

8.10.9            The Company has not made any transfers of value within section
                  94 IHTA.

8.11              EVENTS SINCE THE BALANCE SHEET DATE
                  Since the Balance Sheet Date:-

8.11.1            the Company has not disposed of any asset (including trading
                  stock) or made any supply of any service or business facility
                  of any kind (including a loan of money or the letting, hiring
                  or licensing of any property whether tangible or intangible)
                  in circumstances where the consideration actually received or
                  receivable for such disposal or supply is less than the
                  consideration which could be deemed to have been received for
                  the purposes of Taxation;

8.11.2            no Event has occurred which gives rise to a liability to
                  Taxation to the Company on deemed (as opposed to actual)
                  income, profits or gains or which results in the Company
                  becoming liable to pay or bear a liability to Taxation
                  directly or primarily chargeable against or attributable to
                  another person, firm or company;

8.11.3            the Company has not made or received any distributions for any
                  Taxation purpose;

8.11.4            the Company has not surrendered or claimed any ACT under
                  Chapter V Taxes Act or any losses by way of group relief under
                  the Taxes Act;


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<PAGE>

8.11.5            the Company has not paid any remuneration (including
                  emoluments as defined by section 131 and sections 153-168
                  Taxes Act) to any officer, director or employee or to any
                  member of his family or household in excess of such amount as
                  will be deductible in computing the taxable profits of the
                  Company;

8.11.6            no payment has been made by the Company which will not be
                  deductible for the purposes of corporation tax (or any
                  corresponding tax on profits in any relevant foreign
                  jurisdiction), either in computing the profits of the Company
                  or in computing the corporation tax or corresponding tax
                  chargeable on it; and

8.11.7            no accounting period (as defined in section 12 Taxes Act) of
                  the Company has ended as referred to in section 12(3) of that
                  Act.

8.12              VALUE ADDED TAX

8.12.1            In relation to VAT the Company has complied with all statutory
                  provisions, rules, regulations, orders and directions and made
                  all necessary returns; and within the prescribed time limits
                  provided all necessary information and documents to HM Customs
                  and Excise and paid all amounts due to the proper person.

8.12.2            The Company has at all times kept and preserved in all
                  material respects complete correct and up-to-date records,
                  invoices and other documents required for the purposes of VAT.

8.12.3            The Company has not been required by HM Customs and Excise to
                  give security under paragraph 4 of schedule 11 to the VATA.


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<PAGE>

8.12.4            All VAT payable upon the importation of goods and all duties
                  of customs and excise payable in respect of any assets
                  (including trading stock) imported or owned by the Company
                  have been paid in full.

8.12.5            The Company is not liable and will not (in respect of anything
                  done before Completion) be liable to any interest, penalty or
                  surcharge in respect of VAT and in particular (but without
                  prejudice to the generality of the foregoing) the Company is
                  and will not be so liable to any penalty, interest or
                  surcharge pursuant to sections 59, 63 to 70 and 74 VATA.

8.12.6            The Company is not and has not at any time been a member of a
                  group of companies for VAT purposes.

8.12.7            The Company is not and has not agreed to become an agent,
                  manager or factor for the purposes of sections 47 or 48 VATA
                  of any person who is not resident in the United Kingdom.

8.12.8            The Company has not incurred any expenditure in the ten years
                  preceding Completion on capital items such that the provisions
                  of Part XV of The Value Added Tax Regulations 1995 may apply
                  to the Company.

8.12.9            The Company obtains credit for all input tax paid or suffered
                  by it.

8.13              VAT ON PROPERTY

8.13.1            The Company does not own the fee simple in any building or
                  civil engineering work which is uncompleted or which was
                  completed (within the meaning of Note (2) to Group 1 Schedule
                  9 VATA) less than three years before the date of this
                  agreement.

8.13.2            The Disclosure Letter contains full particulars of:


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8.13.2.1          any election under paragraph 2 Schedule 10 VATA to waive
                  exemption from VAT in relation to any land made by the Company
                  or by any member or former member of any group of companies of
                  which the Company is or was registered for VAT purposes; and

8.13.2.2          any agreement or other arrangement to which the Company is a
                  party whereby the Company has agreed not to waive exemption
                  from VAT pursuant to paragraph 2 Schedule 10 VATA in relation
                  to any land.

8.13.3            he Company has not given or accepted any certificate as to
                  zero-rating under the provisions referred to in section 62
                  VATA.

8.13.4            The Warranties contained in this paragraph 8.13 shall apply as
                  if references to the Company include not only the Company but
                  also every other company which is or was at any time a member
                  of the same group of companies for VAT purposes or for which
                  an application to become such a group member has been made
                  within the preceding three months (including without
                  limitation any parent of the Company or parent or subsidiary
                  of such parent).

8.14              EMPLOYEE SHARE SCHEMES

8.14.1            The Disclosure Letter contains full details of all share
                  schemes (including those approved by the Inland Revenue and
                  unapproved schemes) which the Company operates or in which its
                  UK employees are entitled to participate, together with copies
                  of any approvals issued by the Inland Revenue in respect of
                  such schemes and nothing has been done to prejudice the
                  approved status of any such schemes.


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<PAGE>

8.14.2            The Disclosure Letter contains full details of any issue of
                  shares or an interest in shares by the Company in the
                  circumstances described in section 77 to 89 Finance Act 1988
                  and the Company has complied with section 85 Finance Act 1988.

8.14.3            The Disclosure Letter contains a copy of the rules of any
                  profit related pay schemes which the Company operates or has
                  operated, or in which its UK employees are or have been
                  entitled to participate, in any year commencing prior to
                  Completion, together with copies of any approvals issued by
                  the Inland Revenue in respect of such schemes, and nothing has
                  been done to prejudice the approved status of any such schemes
                  which have at all times been operated in accordance with any
                  rules governing the scheme and relevant Taxation legislation.

8.15              SECONDARY LIABILITY

8.15.1            No transaction or Event has occurred in consequence of which
                  the Company is or may be held liable for any Taxation or
                  deprived of reliefs or allowances otherwise available to it or
                  may be otherwise held liable for any Taxation for which some
                  other company or person was primarily liable (whether by
                  reason of any such other company being or having been a member
                  of the same group of companies or otherwise).

8.15.2            The Company is not, nor will it become, liable to pay, or make
                  reimbursement or indemnity in respect of, any Taxation (or any
                  amount corresponding to Taxation) in consequence of the
                  failure by any other person to discharge that Taxation or
                  amount within any specified period or otherwise, where the
                  Taxation or amount relates to a profit, income or


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<PAGE>

                  gain, transaction, Event, omission or circumstances arising,
                  occurring or deemed to arise or occur (whether wholly or
                  partly) before Completion.

8.16              INHERITANCE TAX

8.16.1            No shares in or assets of the Company were acquired by it or
                  (as the case may be) the Vendors in circumstances such that
                  they continued to be subject to any Inland Revenue charge to
                  which they were subject immediately prior to such acquisition
                  or such that, if they had been subject to an Inland Revenue
                  charge immediately prior to such acquisition, they would have
                  continued to be subject to it.

8.16.2            No shares in or assets of the Company are subject to any such
                  power of sale, charge or mortgage as is mentioned in section
                  212 IHTA and there are no circumstances which might lead to
                  such a power arising.

8.17              PAYMENTS EQUIVALENT TO TAX

8.17.1            The Company has not in the previous seven years entered into
                  any indemnity, guarantee or covenant under which the Company
                  has agreed or can be procured to meet or pay a sum equivalent
                  to or by reference to another person's liability to Taxation.

8.17.2            The Company is not liable nor has any Event or omission
                  occurred in consequence of which the Company could at any time
                  become liable to make a payment to any person as a result of
                  the discharge by that person of any liability of the Company
                  to Taxation incurred on or before Completion.

8.18              LOAN RELATIONSHIPS


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                  All interest, discounts or premiums payable by the Company in
                  respect of its loan relationships within the meaning of
                  Chapter II of Part IV of the Finance Act 1996 are capable of
                  being brought into account as a debit for the purposes of that
                  Chapter as and to the extent that they are from time to time
                  recognised in the Company's accounts (assuming that the
                  accounting policies and methods adopted for the purpose of the
                  Accounts continue to be so adopted).

8.19              CUSTOMS DUTIES

                  The Company has complied with all statutory provisions, rules,
                  regulations, orders and directions and made all necessary
                  returns in relation to the collection and payment of customs
                  duties, excise duties and other charges having an equivalent
                  effect and has provided all necessary information and
                  documentation and paid all amounts due to HM Customs and
                  Excise in relation to such charges within the prescribed time
                  limits.

8.20              WITHDRAWAL OF RELIEFS

                  No relief which has been treated as an asset in preparing the
                  Accounts could or might effectively be withdrawn, postponed,
                  restricted or otherwise lost as a result of the sale and
                  purchase under this Agreement or any other Event or
                  circumstance occurring or arising at any time after the
                  Balance Sheet Date.

8.21              TAX ADMINISTRATION

                  In relation to the Company, the Disclosure Letter gives full
                  details of:

8.21.1            all determinations made under section 41A TMA;


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8.21.2            all directions reducing any amounts so determined pursuant to
                  section 41B TMA;

8.21.3            all assessments to Taxation made by the Revenue, and any such
                  determinations under section 41A TMA and directions under
                  section 41B TMA, which are subject to appeal or have otherwise
                  not become final at the date of this agreement; and

8.21.4            all payments of Taxation, and claims for repayment of
                  Taxation, made in respect of any period for which no
                  assessment to Taxation has been issued or become final (and
                  whether pursuant to section 10 Taxes Act or otherwise).

CONTRACTS AND COMMITMENTS

9.1               CAPITAL COMMITMENTS

                  The Company had no capital commitments at the Balance Sheet
                  Date and since then the Company has not made any capital
                  expenditure or incurred any capital commitments.

9.2               SUBSISTING CONTRACTS

                  The Disclosure Letter contains true, complete and accurate
                  copies (incorporating all the terms which currently apply) of
                  every contract, covenant, commitment or arrangement to which
                  the Company is a party and in respect of which any party to
                  them has or may have any outstanding liability and which:-

9.2.1             is of an unusual or abnormal nature, or outside the ordinary
                  and normal course of business;

9.2.2             is for a fixed term of more than six months;


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9.2.3             is of a long-term nature (that is, unlikely to have been fully
                  performed, in accordance with its terms, more than six months
                  after the date on which it was entered into or undertaken);

9.2.4             is incapable of termination in accordance with its terms, by
                  the Company, on sixty days' notice or less;

9.2.5             is of a loss-making nature (that is, known to be likely to
                  result in a loss to the Company on completion or performance);

9.2.6             cannot readily be fulfilled or performed by the Company on
                  time without undue, or unusual, expenditure of money, effort
                  or personnel;

9.2.7             involves payment by the Company by reference to fluctuations
                  in the index of retail prices, or any other index or in the
                  rate of exchange for any currency;

9.2.8             involve an aggregate outstanding expenditure by or an
                  aggregate outstanding payment to the Company of more than
                  L25,000;

9.2.9             involves, or is likely to involve, the supply of goods the
                  aggregate sales (or purchase) value of which will represent in
                  excess of 10 per cent of the turnover for the preceding
                  financial year of the Company;

9.2.10            is a contract for hire or rent, hire purchase, or purchase by
                  way of credit sale or periodical payment;

9.2.11            is a contract whereby the Company has been appointed to act or
                  has appointed someone else to act as an agent or as a
                  distributor or franchisee;

9.2.12            is an agreement for the supply of services (other than for
                  gas, water or electricity or maintenance contracts); or



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<PAGE>

9.2.13            is capable of being terminated or altered in any way as a
                  consequence of the Purchaser's acquisition of any Shares.

                  and (save as so disclosed) the Company has not entered into
                  any such contract, covenant, commitment or arrangement;

9.3               MORTGAGES ETC

                  The Company has not created nor has it agreed to create any
                  loan capital or any mortgage, debenture, lien, charge or other
                  similar encumbrance or security interest over all or any of
                  its property, assets, undertaking, goodwill, reserves or share
                  capital.

9.4               GUARANTEES ETC

                  There are no guarantees, suretyships, indemnities or similar
                  commitments (whether secured or unsecured) given by the
                  Company in respect of which obligations or liabilities
                  (whether actual or contingent) are still outstanding.

9.5               NO LOANS

                  The Company has not made any loans or advanced any monies or
                  credit to any person, firm or company (other than credit given
                  on normal commercial terms in the ordinary and normal course
                  of business).

9.6               NO PARTNERSHIP ETC

                  The Company is not a member of any partnership, joint venture,
                  trade association, society or other group, whether formal or
                  informal and whether or not having a separate legal identity,
                  nor is any such body relevant to nor does any such body have
                  any material influence over the business of the Company as now
                  carried on.


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9.7               DISCOUNTS, REBATES AND SIMILAR ARRANGEMENTS

                  The Disclosure Letter contains:-

9.7.1             full details of the policy and practice of the Company with
                  respect to the offer or grant by it to any of its customers of
                  discounts, over-riders, rebates, allowances and other special
                  terms or similar arrangements;

9.7.2             full details of all discounts, over-riders, rebates,
                  allowances and other special terms or similar arrangements
                  offered or granted to the Company by any of its suppliers;

9.7.3             full details of all agreements and arrangements for the
                  importing of goods from overseas together with full details of
                  arrangements with overseas distributors, agents and commission
                  houses for such importing; and

9.7.4             full details of the policy and practice of the Company with
                  respect to the offer or grant by it to any of its clients of
                  any other special terms.

9.8               FORWARD CONTRACTS

                  The Company does not have any unmatched open positions with
                  respect to forward purchases and/or sales of any commodity,
                  stock or foreign currency and none of such open positions will
                  involve the Company in a loss.

9.9               OUTSTANDING OFFERS

                  There is no offer or tender (or the like) given or made by the
                  Company which is still outstanding and capable of giving rise
                  to a contract merely by the unilateral act of any third party.

9.10              INSIDER CONTRACTS


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                  None of the Vendors nor any of their Associates nor any person
                  in which any of them has or had any interest (direct or
                  indirect, either solely or jointly with any other party and
                  whether as shareholder, employee, director, consultant or
                  otherwise) has (or has ever had) a trading relationship with
                  the Company nor have any of them ever entered into any other
                  type of transaction or arrangement with the Company (other
                  than in the capacity as a shareholder or employee of the
                  Company); and none of them provides (or has in the past
                  provided) goods or services in competition with the Company.

9.11              NON-ARMS LENGTH CONTRACTS

                  The Company is not a party to, nor have its profits or
                  financial position during the three years prior to the date
                  hereof been affected by, any contract or arrangement which is
                  not of an entirely arms-length nature made on open market
                  terms.

9.12              DEFAULTS, ETC

9.12.1            None of the obligations owed by any third party to the Company
                  is unenforceable and no Event has occurred as regards the
                  Company which would entitled any third party to terminate any
                  contract or benefit enjoyed by the Company or call in any
                  money before the normal due date therefor.

9.12.2            Neither the Company nor any other party to any agreement,
                  commitment, transaction or arrangement with the Company is in
                  default under any such agreement and there are no
                  circumstances likely to give rise to such a default.


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9.13              LIABILITIES

9.13.1            There are no liabilities (including contingent liabilities)
                  which are outstanding on the part of the Company other than
                  those liabilities disclosed in the Accounts or the Management
                  Accounts or incurred, in the ordinary and normal course of
                  trading, since the Balance Sheet Date.

9.13.2            There is no indebtedness or liability due, owing or incurred
                  by the Company to the Vendors or any of their Associates
                  whether actually or contingently, whether solely or jointly
                  with any other person and whether as principal or surety and
                  there is no such indebtedness or liability due, owing or
                  incurred to the Company by the Vendors or any of their
                  Associates.

9.13.3            There are no outstanding liabilities or commitments on the
                  Company arising from any arrangements for the disposal of any
                  shares, property or other assets (other than in the ordinary
                  and normal course of business) previously owned by the
                  Company.

9.14              PAYMENTS TO CREDITORS

                  The Company has at all times paid its creditors within the
                  times agreed with such creditors and there are no debts owing
                  by the Company which are overdue for payment.

9.15              GOVERNMENT GRANTS

9.15.1            The Company has not applied for, or received, any grant,
                  subsidy or financial assistance from any government department
                  or agency or any local or other authority, whether under any
                  of the Industry Acts, or a


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                  regional development grant, or temporary employment subsidy or
                  otherwise.

9.15.2            The Company has not done (or omitted to do) any act or thing
                  which could result in any investment grant, employment subsidy
                  or other similar payment made (or due to be made) to it,
                  becoming repayable, or being forfeited or withheld in whole or
                  in part.

9.16              RESTRICTIVE PRACTICES

                  The Company is not a party to any agreement, practice or
                  arrangement which contravenes or is subject to registration
                  under the Restrictive Trade Practices Act 1976, the Resale
                  Prices Act 1976 or the Competition Act 1980 or which
                  contravenes the provisions of the Fair Trading Act 1973 or
                  which would or might either result in a reference to a
                  "consumer trade practice" within the meaning of Section 13 of
                  the Fair Trading Act 1973 or to the Consumer Protection
                  Advisory Committee under Part II of that Act or contravene any
                  of the provisions of Article 85 or 86 of the Treaty of Rome or
                  any other anti-trust or consumer protection legislation.

9.17              NO DISCLOSURES OF CONFIDENTIAL INFORMATION

                  The Company has never disclosed to any person (save in the
                  ordinary and normal course of business or other than to the
                  Purchaser or to its professional advisers) any of its secret
                  or confidential information (including any of its know-how,
                  trade connections, price lists, lists of customers or
                  suppliers, financial information, profit margins or


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                  projections); and so far as the Vendors are aware no
                  unauthorised disclosure of such information has ever been
                  made.

9.18              NO RESTRICTIONS ON COMPANY

                  The Company is not a party to any secrecy or confidentiality
                  agreement or arrangement which may restrict the use or
                  disclosure of information nor has it given any covenants
                  limiting or excluding its right to do business and/or compete
                  in any area or field with any other person.

9.19              RELATIONSHIPS WITH THIRD PARTIES

9.19.1            No person presently doing business with the Company nor any
                  customer or supplier who is in the habit of purchasing from or
                  selling to the Company (as the case may be) is, so far as the
                  Vendors are aware, likely to cease to do so or otherwise
                  substantially reduce its purchases from or supplies to the
                  Company during the twelve calendar months following
                  Completion.

9.19.2            Neither more than 5 per cent of the aggregate amount of all
                  the purchases nor more than 5 per cent. of the aggregate
                  amount of all the sales of the Company in any trading period
                  of 52 weeks are obtained from or made to the same supplier or
                  customer (together with any person, firm or company in any way
                  connected with such supplier or customer).

9.19.3            There is no contract or arrangement (whether written or oral)
                  to which the Company is a party which will or may be
                  determined or under which any right of the Company may be
                  adversely affected (or pursuant to which any other party may
                  require the adoption of terms less favourable to the Company
                  than those subsisting in the absence of any change) by reason
                  of


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<PAGE>

                  the sale of the Shares to the Purchaser or the implementation
                  of any provision of this agreement.

10.               PENSIONS
- --------------------------
10.1              DEFINITIONS

                  For the purpose of paragraphs 10.2 to 10.5:

                  "APPROVED" means approved by the Inland Revenue for the
                  purposes of Chapter I or Part XIV of the Taxes Act and a
                  reference to "APPROVAL" is to be construed accordingly.

                  "DISCLOSED SCHEMES" means the Synopsys Scientific Systems
                  Executive Pension Scheme established pursuant to a trust deed
                  dated 26 March 1999 ("THE EXECUTIVE SCHEME"), the Group
                  Personal Pension Plan, the Group Life Assurance Plan and the
                  Group Dependants Plan; and

                  "EMPLOYEE" means a director or employee or former employee or
                  former director of the Company.

10.2              WARRANTIES

10.2.1            GENERAL PENSION WARRANTIES

                  (1)       Save for the Disclosed Schemes there is not in
                            operation, and no proposal has been announced to
                            enter into or establish, any agreement, arrangement,
                            custom or practice


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                           (whether legally enforceable or not and whether
                           Approved or not and whether funded or otherwise) for
                           the payment of, or payment of a contribution towards,
                           a pension, allowance, lump sum or other similar
                           benefit on retirement, death, termination of
                           employment (whether voluntary or not) or during
                           periods of sickness or disablement, for the benefit
                           of an Employee or an Employee's dependants.

                  (2)       All data and information disclosed in relation to
                            the Disclosed Schemes is up-to-date and complete.

10.2.2            SPECIFIC PENSION WARRANTIES

                  (1)      No discretion or power has been exercised (or
                           practice followed) under the Disclosed Schemes in
                           relation to any of the Employees to:

                           (a)      augment benefits (whether in relation to
                                    early retirement or otherwise):

                           (b)      admit to membership a person who would not
                                    otherwise have been eligible for admission
                                    to membership;

                           (c)      admit to membership a person on terms which
                                    provided for or envisaged the payment of a
                                    transfer value or transfer of assets from
                                    another scheme to the Disclosed Schemes in a
                                    case in which the payment or transfer has
                                    not been made or has not been made in full;

                           (d)      provide a benefit which would not otherwise
                                    be provided;

                           (e)      pay a contribution which would not otherwise
                                    have been paid.

                  (2)      Each benefit (except a refund of contributions)
                           payable under the Disclosed Schemes on the death of a
                           member of the Disclosed Scheme or during periods of
                           sickness or disability of the member


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<PAGE>

                           is, at the date of this Agreement, fully insured
                           under a policy effected with an insurance company of
                           good repute. To the best of the Vendors knowledge
                           each member has been covered for that insurance by
                           that insurance company at its usual rates and on its
                           usual terms for person in good health and all
                           insurance premiums payable have been paid.

                  (3)      No plan, proposal or intention to amend, discontinue
                           (in whole or in part) or exercise a discretion in
                           relation to the Disclosed Schemes has been
                           communicated to a member of the Disclosed Schemes.

                  (4)      Each employee who has been admitted to or promised
                           admission to membership of the Executive Scheme has
                           been admitted or promised admission on terms which
                           are consistent with the continued treatment of the
                           Executive Scheme as Approved and (if applicable) the
                           provisions of Part II of Schedule 6 to the Finance
                           Act 1989. The substance of the terms of admission or
                           promised admission have been communicated to the
                           Employee.

                  (5)      There has been no breach of the trusts of the
                           Executive Scheme.

                  (6)      There is no civil, criminal, arbitration,
                           administrative or other proceedings or dispute (which
                           includes, without limitation, contact with OPAS to or
                           the Pensions Ombudsman) in relation to any Employee
                           concerning the Executive Scheme by or against the
                           trustees or administrator of the Executive Scheme,
                           the Vendor or


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<PAGE>

                           the Company and none is pending or threatened. The
                           Vendor is not aware of a matter in relation to any
                           Employee which might give rise to a proceeding or
                           dispute of that type.

                  (7)      All employer and member contributions due to the
                           Executive Scheme have been paid to the trustees in
                           accordance with the payments schedule (as required
                           by, and defined in, Section 87 of the Pensions Act
                           1995).

                  (8)      All fees, charges and expenses of whatever nature
                           (including, without limitation, all levies to be paid
                           under the Pensions Act 1995) with respect to the
                           Disclosed Schemes have been paid and no services have
                           been rendered for which an account or invoice has not
                           been delivered.

                  (9)      No claim has been made or threatened against the
                           Vendor or the trustees or administrators of the
                           Disclosed Schemes, or against any person whom the
                           Vendor is or may be liable to indemnify or
                           compensate, in connection with the Disclosed Schemes
                           (other than routine claims for benefits), there are
                           no circumstances which may give rise to any such
                           claim and the Vendor has not given any indemnity to
                           any person in connection with the Disclosed Schemes.

10.2.3            COMPLIANCE

                  (1)      The Executive Scheme is Approved and there is no
                           matter which might have the Inland Revenue reason to
                           withdraw Approval.


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                  (2)      The Executive Scheme is a contracted-out scheme for
                           the purposes of the Pension Schemes Act 1993 and has
                           been administered in accordance with the
                           contracting-out requirements of that Act. The Company
                           holds a current contracting-out certificate issued in
                           relation to the Disclosed Scheme.

                  (3)      The Executive Scheme has been designed to comply
                           with, and has been administered in accordance with
                           all applicable legal and administrative requirements
                           (including, without limitation, Article 141 of the
                           Treaty of Rome as it applies to the eligibility of an
                           Employee to join the Executive Scheme) and the
                           trusts, powers and provisions of the Executive
                           Scheme.

10.2.4            THE PENSIONS ACT 1995

                  The Executive Scheme complies in all respects with the
                  provisions of the Pensions Act 1995.

10.2.5            SEX-EQUALITY

                  (1)      The Executive Scheme has been operated at all times
                           in accordance with the documents constituting the
                           same (as lawfully amended from time to time) and all
                           applicable laws and, without limitation to the
                           foregoing, all decisions made by the trustees and
                           administrators of the Executive Scheme have been made
                           in accordance with their powers and duties as the
                           trustees or administrators respectively.

                  (2)      No part-time Employee or former Employee has either:


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                           (a)      been excluded from membership of the
                                    Executive Scheme; or

                           (b)      been provided with benefits under the
                                    Executive Scheme which are different from
                                    those provided for, or in respect of,
                                    full-time Employees or former Employees or
                                    do not comply with the requirements of
                                    Article 141 of the Treaty of Rome.

                  (3)       The Executive Scheme has not accepted any transfer
                            value from a pension arrangement ("the Playing
                            Scheme") in respect of an Employee or former
                            Employee where the Paying Scheme in relation to such
                            transfer value did not comply with the requirements
                            of Article 142 of the Treaty of Rome (which, for the
                            avoidance of doubt, includes obligations in respect
                            of part-timers).

OFFICERS AND EMPLOYEES

11.1              DETAILS

                  The Disclosure Letter contains an accurate and complete list
                  of all officers and employees of the Company as at the date of
                  this agreement, showing all remuneration payable and other
                  benefits provided or which the Company is bound to provide
                  either now or in the future.

11.2              STATUTORY NOTICES

                  All appropriate notices have been properly issued under the
                  Employment Rights Act 1996 to all employees (including
                  directors) of the Company.

11.3              WORKING TIME REGULATIONS


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<PAGE>

11.3.1            The Company has complied in full with its obligations under
                  the Working Time Regulations 1998 (THE "1998 REGULATIONS") in
                  relation to the business and, in particular and without
                  limitation, with its record keeping obligations under
                  Regulations 5(4) and 9 of the 1998 Regulations and the
                  requirements under Regulations 4, 6, 7 and 8 of the 1998
                  Regulations.

11.3.2            The Disclosure Letter contains true and complete copies of:-

11.3.2.1          all relevant agreements entered into pursuant to the 1998
                  Regulations (or, if in standard form, a copy of the standard
                  form) and a list of all workers covered by any such agreement;
                  and

11.3.2.2          a list of all workers whom the Company regards as falling
                  within the terms of Regulation 20 or 21 of the 1998
                  Regulations.

11.4              TERMS OF EMPLOYMENT AND CONSULTANCY

                  The Disclosure Letter contains true, complete and accurate
                  copies (incorporating all the terms which currently apply or a
                  memorandum of such terms) of all service agreements,
                  consultancy agreements and letters of engagement which have
                  been made with any employee or consultant of the Company and
                  of specimens of the standard terms of employment on which any
                  employee of the Company is now employed together with a note
                  showing which employees are employed under which type of
                  standard terms.

11.5              NO BONUS OR COMMISSION ARRANGEMENTS

                  The Company is not bound or accustomed to make periodical or
                  other payments (other than normal fixed salaries and wages) to
                  employees, ex-


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                  employees, officers, consultants or others and no employee,
                  officer or consultant has remuneration on a profit sharing or
                  commission basis or by reference to the turnover, profits,
                  sales or assets of the Company.

11.6              NO SHARE OPTION SCHEME

                  The Company does not have and never has had any share option,
                  share incentive, profit sharing or any other similar scheme
                  other than the Share Option Scheme.

11.7              INCREASES SINCE BALANCE SHEET DATE

                  Since the Balance Sheet Date:-

11.7.1            no remuneration or benefit has been paid or given or agreed to
                  be paid or given to any officer, employee or consultant of the
                  Company who is now entitled to remuneration at the rate of at
                  least L25,000 per annum except at the rates in force on that
                  date;

11.7.2            no general increase in the wages of the employees of the
                  Company or any section or class of such employees has been
                  made or agreed to be made (whether legally binding or not)
                  either with the employees or their representatives nor has any
                  negotiation or demand for such increase been entered into by
                  or made to the Company; and

11.7.3            the Company has not received or been notified of any wage
                  claim.

11.8              TERMINATION OF EMPLOYMENT

11.8.1            All contracts of employment between the Company and its
                  officers or employees are lawfully determinable by the Company
                  without


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                  compensation by notice (not exceeding the relevant statutory
                  minimum period of notice).

11.8.2            No director or executive of the Company, who is in receipt of
                  remuneration in excess of L20,000 per annum has given or
                  received notice terminating his employment, except as
                  expressly contemplated in this agreement, and no such
                  executive will be entitled to give such notice as a result of
                  the sale of the Shares to the Purchaser.

11.8.3            The Company has no reason to dismiss (nor does it wish to
                  dismiss) any of its employees who is entitled to remuneration
                  of at least L25,000 per annum.

11.9              CLAIMS BY OR AGAINST EMPLOYEES

11.9.1            The Company is not now, nor is it likely to be and has not
                  since the Balance Sheet Date been, engaged in any legal
                  proceedings or arbitration whether as plaintiff or defendant
                  with any trade union or any person who is or has at any time
                  been a director or an employee of the Company.

11.9.2            No person who is or was a director or employee of the Company
                  has any right or made any claim (which has not yet been
                  settled) to any compensation or other payment by reason of the
                  termination of his employment (whether such termination
                  constitutes unfair or wrongful dismissal redundancy or
                  otherwise) or any breach by the Company of his terms of
                  engagement or employment; there are no circumstances likely to
                  lead to any such claims being made; and no gratuitous payment
                  has been made or promised by the Company in connection with
                  the termination or


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                  proposed termination of employment of any past or present
                  director or employee.

11.9.3            No order has been or may be made for the reinstatement or
                  re-engagement of any employee of the Company.

11.10             INDUSTRIAL RELATIONS

                  There is not and never has been any strike, picket, lock-out,
                  go-slow, work-to rule or any other form of industrial dispute
                  taken or threatened against the Company and to the best of
                  knowledge, information and belief of the Vendors there are no
                  facts or circumstances which might lead to any such industrial
                  dispute.

11.11             TRADE UNION RECOGNITION

                  No claim has been made by any trade union for recognition or
                  for any improvement or amendment to the terms or conditions of
                  employment of any employees of the Company and no claim for
                  recognition has been referred to the Advisory Conciliation and
                  Arbitration Service or to the Central Arbitration Committee
                  nor is any trade union recognised by the Company in respect of
                  any class of employees for any purpose whatsoever.

INSURANCE

12.1              FULL COVER

                  The Company is and has been at all material times fully
                  covered by valid insurance against the normal risks for the
                  type of business carried on and assets and stock-in-trade
                  owned or used by it (including adequate insurance for the full
                  reinstatement value of such business, assets and


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                  stock-in-trade and against loss of profit) and nothing has
                  been done or omitted to be done which could make any policy of
                  insurance void or voidable.

12.2              DETAILS OF INSURANCE COVER

                  The Disclosure Letter contains copies of all policies of
                  insurance maintained by the Company (or which is maintained by
                  a third party but in which the Company has an interest) and
                  the cover afforded under such policies (including details of
                  current premiums, excess levels, any unusual terms or
                  conditions contained in such policies, a history of claims
                  made by the Company at any time under any insurance policies
                  and circumstances which have arisen and may give rise to a
                  claim under such policies).

12.3              PREMIUMS PAID

                  All premiums payable in respect of any insurance policy in
                  which the Company has an interest have been duly paid.

12.4              NO OUTSTANDING CLAIMS

                  There are no claims outstanding by the Company under any
                  insurance policy nor, so far as the Vendors are aware, are
                  there any circumstances likely to give rise to any such claim
                  or which would or might be required under any insurance policy
                  to be notified to the insurers or which might lead to any
                  liability under such insurance policies being avoided by the
                  insurers or the premiums being increased.

12.5              EFFECT OF THIS AGREEMENT


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                  No cover afforded by any policy of insurance which is
                  maintained by the Company or which is maintained by a third
                  party but in which the Company has an interest will terminate
                  or be terminable at the option of the insurer or any third
                  party by reason of the implementation of this agreement.

LITIGATION AND LEGAL PROCEEDINGS

13.1              DEFAULTS BY THE COMPANY

                  So far as the Vendors are aware the Company is not and since
                  the Balance Sheet Date has not been:-

13.1.1            in default under any agreement, deed, instrument, arrangement
                  or covenant to which it is a party or in respect of any other
                  obligations or restrictions binding upon it;

13.1.2            liable in respect of any representations or warranties
                  (whether express or implied) or other matters giving rise to a
                  duty of care on the part of the Company; or

13.1.3            liable to any fine or penalty as a result of committing or
                  omitting to do any act or thing which could give rise to such
                  a liability; or

13.1.4            subject to any order or judgment given by any Court or
                  government agency and has not been party to any undertaking or
                  assurance given to any Court or governmental agency which is
                  still in force; or

13.1.5            in default under any provisions existing by reason of
                  membership of any association or body.

13.2              LEGAL PROCEEDINGS


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                  The Company is not and has not since the Balance Sheet Date
                  been engaged and so far as the Vendors are aware there are no
                  circumstances likely to lead to the Company becoming engaged
                  in any legal proceedings (civil or criminal) or arbitration as
                  plaintiff, defendant or otherwise howsoever except as
                  plaintiff in normal debt collection and in respect of which
                  the aggregate amount of debts due to the Company does not
                  exceed L500.

13.3              DISPUTES WITH GOVERNMENT DEPARTMENTS

                  There is no dispute with any revenue or other government,
                  local authority, administrative, official department entity or
                  agency in the United Kingdom or elsewhere, in relation to the
                  affairs of the Company and so far as the Vendors are aware
                  there are no facts which may give rise to any such dispute.

13.4              PERSONAL INJURY CLAIMS

                  There are no claims pending or threatened against the Company
                  by an employee or third party in respect of any accident or
                  injury which are not fully covered by insurance.

13.5              DEMANDS TO PAY

                  No demand has been served upon the Company under section 123
                  of the Insolvency Act 1986 and the Company has not received
                  notice (whether formal or informal) from any lenders of money
                  to the Company requiring repayment or intimating the
                  enforcement by such lenders of any security


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                  which they may hold over any assets of the Company and there
                  are no circumstances likely to give rise to any such notice
                  being given.

13.6              ADVERTISING MATERIALS

                  So far as the Vendors are aware, all advertising and marketing
                  materials used in connection with the Company's business
                  comply with all legal requirements in all countries in which
                  these materials are used or proposed to be used. Such
                  materials are not defamatory and there are no grounds under
                  which such materials could be challenged for any reason
                  whatsoever including, without limitation, defamation, trade
                  libel or any analogous law.

14.               ENVIRONMENTAL MATTERS

                  So far as the Vendors are aware the Company has complied with,
                  all legislation (including regulations, codes of practice,
                  circulars and guidance notes made thereunder) relating to
                  environmental matters, including (but without limitation)

14.1              waste;

14.2              contaminated land;

14.3              discharges to (i) land and (ii) ground and surface water and
                  (iii) sewers;

14.4              emissions to air;

14.5              noise;

14.6              dangerous, hazardous or toxic substances and materials;

14.7              nuisance;

14.8              health and safety;


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                  and the Vendors are not aware of any actions, claims or
                  proceedings (whether actual or potential) nor has any other
                  reason to believe that the Vendor has or is likely to have any
                  liability in relation to such matters.


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FIFTH SCHEDULE

PROTECTION FOR THE VENDORS

1.                The Purchaser acknowledges that in entering into this
                  agreement:

1.1               It has not relied on any warranties, representations,
                  covenants, undertakings, indemnities or other statements
                  whatsoever (whether expressed or implied and whether written
                  or oral), other than those expressly set out in this agreement
                  and the Purchaser further acknowledges that the Vendors have
                  not given any such warranties, representations, covenants,
                  undertakings or indemnities; and

1.2               No information, advice or assurances it or anyone on its
                  behalf may have received from the Vendors, the Vendors'
                  advisers or anyone else on the Vendors' behalf in relation to
                  the Company or this agreement or its negotiation may be
                  legally relied upon in any manner, save in each case for any
                  information, advice or assurances which are expressly set out
                  or referred to in the Warranties, the Tax Deed and this
                  agreement.

2.                No right or rescission shall be available to the Purchaser by
                  reason of any breach of the Warranties or the Tax Deed nor
                  shall the Purchaser have the right to claim that any such
                  breach constitutes repudiation of the agreement.

3.                The Vendors shall not be liable under the Warranties or the
                  Tax Deed in relation to:

3.1               Any matter or Event properly and adequately provided for or
                  reserved or specifically noted in the Accounts;


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3.2               Any matter where the claim arises or is increased as a result
                  of the imposition of Taxation as a consequence of any change
                  in the law or change in any practice or procedure published by
                  any Taxation Authority coming into force after Completion with
                  retrospective effect or to the extent that that claim arises
                  or is increased by an increase in rates of Taxation after
                  Completion with retrospective effect;

3.3               Any liability for Taxation which would not have arisen but for
                  any claim, election, surrender, revocation or disclaimer made,
                  or notice or consent given after Completion (other than on the
                  giving or doing of which was taken into account in preparing
                  the Accounts) under the provision of any enactment or
                  regulation relating to Taxation;

3.4               Any claim which arises or is increased because of timing
                  differences or changes in accounting practice or policy in the
                  future accounts of the Company from those adopted in the
                  Accounts;

3.5               Any liability for Taxation which would not have arisen or
                  would have been reduced or eliminated but for a failure or
                  omission on the part of the Company or the Purchaser after
                  Completion to make any claim, election, surrender or
                  disclaimer or to give any notice or consent or do any other
                  thing under or in connection with a provision of any enactment
                  or regulation relating to Taxation;

3.6               Any claim which would not have arisen or would have been
                  reduced or eliminated but for an act, omission, Event,
                  transaction, arrangement or default performed or allowed to
                  occur by the Purchaser or the Company


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<PAGE>

                  after Completion otherwise than in the ordinary course of
                  business and which the Purchaser knew or ought reasonably to
                  have known would have given rise to a claim under this
                  agreement;

3.7               Any claim arising as a result of the Company ceasing to be
                  resident in the United Kingdom for Taxation purposes.

3.8               Any liability for Taxation which is in respect to actual
                  income, profits or gain of the Company arising in the ordinary
                  and normal course of business in the period from the Balance
                  Sheet Date to Completion.

4.                The Vendors shall not be liable for any claim under the
                  Warranties in relation to any matter or Event fairly disclosed
                  in the Disclosure Letter.

5.                The Vendors shall not be liable for any claim under the
                  Warranties in relation to any claim which has been or is made
                  good otherwise than by the Purchaser.

6.                The aggregate liability of each of the Vendors in respect of
                  all claims under the Warranties and the Tax Deed (including
                  interest and costs) shall not in any circumstances exceed ten
                  per cent of the value of the Consideration attributed to that
                  Vendor (as set out in columns 4 and 5 of Schedule 1). For the
                  purposes of this clause the value of the Consideration Shares
                  shall be an amount equal to the number of Consideration Shares
                  issued to the Vendor multiplied by US$55.575.

7.                Notwithstanding any other provisions of this agreement the
                  aggregate liability of the Vendor Trustees in respect of any
                  claim or claims for breach of the Warranties, Indemnities or
                  under the Tax Deed shall not


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                  exceed the value of (calculated in accordance with clause 8)
                  the trust assets from time to time of the trust fund of which
                  he is a trustee (and for the avoidance of doubt the relevant
                  time for assessing such value shall be the due date for
                  payment of such claim), provided that the Vendor Trustees
                  shall retain in cash or an equivalent sufficient amount to
                  meet their maximum potential liability pursuant to this
                  agreement and, in particular, clause 7 and this Fifth
                  Schedule.

8.                For the purposes of clause 7 the value of the trust assets at
                  any time shall be:

8.1               the realisable value of those assets comprised in the trust
                  assets which are in the hands or under the control of the
                  trustees less

8.2               the estimated amount of any expenses which would be incurred
                  in connection with the realisation of the assets comprised in
                  the trust assets and any liability which would arise on such
                  realisation

8.3               the amount of all liabilities incurred in the proper
                  administration of the Trusts, whether in respect of taxation
                  or otherwise (actual, future or contingent) of the trustee and
                  the trusts.

9.                If the Vendors at any time pay to the Purchaser or the Company
                  an amount pursuant to a claim in respect of the Warranties
                  and/or the Tax Deed and the Purchaser or the Company
                  subsequently becomes entitled to recover from some other
                  person any sum in respect of any matter giving rise to such
                  claim, the Purchaser shall, and shall procure that the Company
                  shall, take all necessary steps as are, in the Purchaser's
                  sole discretion,


                                      108

<PAGE>

                  commercially reasonable to enforce such recovery and shall
                  forthwith repay to the Vendors so much of the amount paid by
                  them to the Purchaser or the Company as does not exceed the
                  sum recovered from such other person less all reasonable
                  costs, charges and expenses and tax properly incurred by the
                  Purchaser or the Company in recovering that sum from such
                  other person.

10.               The Vendor shall have no liability under the Warranties or Tax
                  Deed more than once in respect of the same loss arising out of
                  or in respect of the same act, matter or thing.


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SIXTH SCHEDULE

TAX DEED

THIS DEED is made on                                       2000

BETWEEN:-

(1)               The persons whose names and addresses are set out in the
                  schedule hereto ("COVENANTORS"); and

(2)               PHARMACOPEIA, INC a company incorporated in Delaware, United
                  States of America and having its principal office at 9685
                  Scranton Drive, San Diego, USA 92121-3752 ("PURCHASER").

1.                INTRODUCTION

1.1               By an Agreement ("AGREEMENT") of even date herewith and made
                  between (1) the Covenantors and (2) the Purchaser, the
                  Purchaser agreed to purchase the Shares (as defined in the
                  Agreement).

1.2               The Agreement provides that the Covenantors will deliver today
                  a duly executed deed in this form.

2.                DEFINITIONS AND INTERPRETATION

2.1               In this deed expressions defined in the Agreement shall bear
                  the same meanings unless the context otherwise requires or
                  unless they are expressly given different meanings.

2.2               In this deed unless the context otherwise requires:-

                  "CLAIM" means any notice, demand, assessment, letter or other
                  document issued, or action taken, by or on behalf of the
                  Revenue or any other governmental or statutory authority, body
                  or official, whether of the


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<PAGE>

                  United Kingdom or elsewhere, whereby the Company is or is
                  sought to be placed under a liability to Taxation;

                  "COMPANY" means Synopsys Scientific Systems Limited
                  (registered number 02708693) and/or Synopsys Scientific
                  Systems Inc.;

                  "EVENT" includes any act, transaction or circumstance,
                  including (without limitation) any change in the residence of,
                  or the death of, any person, the execution of the Agreement
                  and Completion;

                  "PURCHASER'S RELIEF" means:

                  (i)      any Relief shown as an asset in the Accounts;

                  (ii)     any Relief of the Company arising in respect of or in
                           consequence of any Event which occurs after
                           Completion;

                  (iii)    any Relief of the Purchaser whenever arising;

                  "RELIEF" includes any loss, allowance, exemption, set-off,
                  credit or deduction relevant to the computation of any
                  Taxation or any right to repayment of Taxation;

                  "TAXATION" includes all forms of taxation, duties (including
                  stamp duty), levies, imposts, charges, withholdings, national
                  insurance and other contributions, in the nature of taxation
                  and PAYE liabilities (including any related penalty, fine,
                  interest or surcharge) whether of the United Kingdom or
                  elsewhere.

2.3               The covenants contained in this deed shall be construed as
                  separate and independent and none of them shall be affected or
                  restricted by any other except to the extent that any payment
                  made by the Covenantors and


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<PAGE>

                  received by the Purchaser in respect of one covenant shall
                  discharge the same liability under the other covenants which
                  shall arise out of the same subject matter.

3.                COVENANTS

3.1               The Covenantors jointly and severally covenant with the
                  Purchaser to pay to the Purchaser an amount equal to:-

3.1.1             any liability to Taxation of the Company in respect of, by
                  reference to or in consequence of any income, profits or gains
                  earned, accrued or received or deemed to have been earned,
                  accrued or received on or before Completion;

3.1.2             any liability to Taxation of the Company in respect of, or in
                  consequence of any Event which occurred or is deemed to have
                  occurred on or before Completion;

3.1.3             any liability to Taxation of the Company for which it is not
                  primarily liable in respect of, by reference to or in
                  consequence of any Event which occurred or is deemed to have
                  occurred on or before Completion and which is payable by the
                  Company by virtue of the person who is primarily liable
                  failing to discharge such liability;

3.1.4             any Taxation for which the Company would have become liable
                  pursuant to clauses 3.1.1 to 3.1.3 (inclusive) but for the
                  utilisation or set off of a Purchaser's Relief;

3.1.5             any Taxation incurred by the Purchaser in respect of any
                  amounts received from the Covenantors pursuant to this deed
                  provided always that this sub-


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<PAGE>

                  clause 3.1.5 shall only apply where the Purchaser is
                  Pharmacopeia, Inc and shall not apply to any successors or
                  assigns of Pharmacopeia, Inc; and

3.1.6             all reasonable costs and expenses actually and properly
                  incurred by the Purchaser in enforcing the provisions of this
                  deed.

3.2.1             All sums payable by the Covenantors under the covenants
                  contained in this deed shall be paid free and clear of all
                  deductions or withholdings or rights of counterclaim or
                  set-off unless the deduction or withholding is required by
                  law.

3.2.2             If the Covenantors are required by law to make any deduction
                  or withholding from any payment under this deed, the sum due
                  from the Covenantors in respect of such payment shall be
                  increased to the extent necessary to ensure that after the
                  making of such deduction or withholding the Purchaser receives
                  and retains a net sum equal to the sum it would have received
                  had no deduction or withholding been required to be made
                  provided always that this sub-clause 3.2.2 shall only apply
                  where the Purchaser is Pharmacopeia, Inc and shall not apply
                  to any successors or assigns of Pharmacopeia, Inc.

4.                EXCLUSIONS

4.1               The covenants in clause 3.1 shall not apply to any liability
                  to Taxation to the extent that:-

4.1.1             a specific provision or reserve in respect of it was made in
                  the Accounts; or


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<PAGE>

4.1.2             the Company is liable in respect of actual income, profits or
                  gains of the Company arising in the ordinary and normal course
                  of business in the period from the Balance Sheet Date to
                  Completion; or

4.1.3             such liability has arisen or has been increased by the
                  Purchaser's failure to comply with its obligations under this
                  deed.

4.2               For the purposes of clause 4.1 none of the following shall be
                  regarded as occurring in the ordinary and normal course of
                  business of the Company:-

4.2.1             an event giving rise to a liability under Part XVII Taxes Act;

4.2.2             a distribution within the meaning given by Part VI with
                  Section 418 Taxes Act;

4.2.3             an acquisition, disposal or supply or deemed acquisition
                  disposal or supply of assets, goods, services or business
                  facilities of any kind (including a loan of money or a
                  letting, hiring or licensing of tangible or intangible
                  property) for a consideration which is treated for Taxation
                  purposes as different from the actual consideration;

4.2.4             an event which results in the Company being liable for
                  Taxation for which it is not primarily liable; and

4.2.5             an event in respect of which Taxation arises as a result of a
                  failure by the Company to deduct, withhold, or account for
                  Taxation.

4.3               The provisions of clauses 7.2 and 7.3 and the Fifth Schedule
                  of the Agreement which refer to the Tax Deed shall apply
                  hereto as if set out in full.

5.                WAIVER


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<PAGE>

                  No delay or omission of the Purchaser in exercising any rights
                  under this deed shall prejudice such rights or be construed as
                  a waiver or partial waiver of such rights, nor shall it
                  exclude the further exercise of such rights.

6.                PAYMENT

6.1               Subject to clause 6.2 and 6.3 the Covenantors shall pay any
                  amounts due under this deed in sterling in cleared funds:

6.1.1             two Business Days prior to the date on which the Taxation in
                  question is payable to the taxation authority demanding it; or

6.1.2             if later, two Business Days prior to the date to which payment
                  of the Taxation in question is deferred following application
                  to the appropriate authority, official, court, tribunal or
                  body of the jurisdiction concerned; or

6.1.3             if later, five business days after the Purchaser serves notice
                  on the Covenantors demanding such payment.

6.2               If the Covenantors are or become liable to make a payment
                  under clause 3.1.4, the Covenantors shall pay such amount in
                  cleared, immediately available funds on or before the later of
                  the date on which the Taxation would have become payable to
                  the authority or official or person demanding it but for the
                  utilisation or set off of the relevant Relief and five
                  business days after the Purchaser serves notice on the
                  Covenantors demanding such payment.


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<PAGE>

6.3               If the Covenantors are or become liable to make a payment
                  under clause 3.1.6, the Covenantors shall pay such amount in
                  cleared, immediately available funds on or before the date
                  which is the later of:

6.3.1             two business days prior to the date on which such costs or
                  expenses are to be paid as notified by the Purchaser to the
                  Covenantors; or

6.3.2             the fifth day after the Purchaser serves written notice on the
                  Covenantors demanding such payment; or

6.3.3             the date on which the Claim to which such costs and expenses
                  relate is payable under this deed.

6.4               Any sums not paid by the Covenantors on the due date for
                  payment as specified in this clause shall bear interest (which
                  shall accrue from day to day after as well as before any
                  judgment for the same) at the annual rate of 1 percentage
                  points above the base rate of Barclays Bank plc from time to
                  time from the due date up to and including the day of actual
                  payment of such sums, such interest to be compounded quarterly
                  and paid by the Covenantors on demand by the Purchaser.

7.                CONDUCT OF CLAIMS

7.1               The Purchaser shall or shall procure that the Company shall
                  give notice to the Covenantors as soon as reasonably
                  practicable after it shall become aware of any Claim in
                  respect of which a claim may be made pursuant to this deed.

7.2               The Purchaser shall and shall procure that the Company shall
                  provide such relevant information and documentation as the
                  Covenantors may


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<PAGE>

                  reasonably request to avoid, dispute, resist, appeal,
                  compromise or defend any Claim and any adjudication in respect
                  thereof ("DISPUTE") subject to the Purchaser and the Company
                  being indemnified to the Purchaser's reasonable satisfaction
                  by the Covenantors against all losses, costs, expenses,
                  interest, penalties and surcharges thereby incurred.

7.3               Subject to the provisions of this clause 7, any dispute
                  relating to a liability to Taxation shall be conducted by the
                  Covenantors but:

7.3.1             the Covenantors shall keep the Purchaser fully informed of all
                  relevant matters and shall promptly forward or procure to be
                  forwarded to the Purchaser copies of all relevant
                  correspondence and other relevant information and
                  documentation;

7.3.2             all communications written or otherwise relating to the
                  dispute which are to be transmitted to a Taxation authority
                  shall first be submitted to the Purchaser for approval and
                  shall only be finally transmitted if such approval is given
                  (such approval not to be unreasonably withheld or delayed);

7.3.3             the appointment of solicitors or other professional advisers
                  shall be subject to the prior written approval of the
                  Purchaser;

7.3.4             the Covenantors shall make no settlement or compromise of the
                  dispute nor agree any matter in the conduct of such dispute
                  which is likely to increase the amount thereof or adversely
                  affect the future liability of the Purchaser or the Company to
                  Taxation without the prior approval of the Purchaser (such
                  approval not to be unreasonably withheld or delayed).


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<PAGE>

7.4               The Purchaser or the Company may without reference to any of
                  the Covenantors admit, settle, discharge, compromise or
                  otherwise deal with any outstanding or future Claim (without
                  prejudice to their rights under this deed) if:

7.4.1             the Covenantors serve a notice on the Company or the Purchaser
                  to the effect that in relation to any such dispute the
                  Covenantors do not wish to take up or continue the conduct
                  thereof;

7.4.2             a period of 10 business days has expired following the service
                  of notice by the Purchaser or, as the case may be, the Company
                  on the Covenantors pursuant to clause 7.1 where either the
                  Covenantors have not made a request to the Purchaser in
                  accordance with clause 7.2 or the Covenantors have made such a
                  request but have failed to provide a duly executed indemnity
                  in the manner stipulated by the Purchaser within the said
                  period;

7.4.3             a period of 10 business days has expired following the service
                  of notice (other than a notice under clause 7.1) by the
                  Purchaser or the Company on the Covenantors to the effect that
                  the Covenantors are not properly and effectively conducting
                  the dispute, if by the expiry of that period the Covenantors
                  have not taken reasonable steps so to conduct the dispute; or

7.5               The Covenantors shall be bound to accept for the purposes of
                  the covenants contained in this deed any admission,
                  settlement, discharge or compromise of any Claim and the
                  outcome of any proceedings relating



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<PAGE>

                  thereto made or arrived at in accordance with the procedures
                  set out in clause 7.4.

7.6               If the Covenantors do not exercise their right to request the
                  Purchaser to take action pursuant to clause 7.2, they shall
                  supply the Company and the Purchaser free of charge with all
                  relevant information, books, papers and other documents in the
                  possession or under the control of all or any of them and
                  shall give or procure the giving (as appropriate) of such
                  statements and other reasonable co-operation by the
                  Covenantors as the Company or the Purchaser may reasonably
                  request or require for the purpose of resisting any Claim.

8.                CORRESPONDING BENEFITS

8.1               If any liability to Taxation which has resulted in payment
                  having been made or becoming due from the Covenantors under
                  this deed gives rise to a Relief or right to a repayment of
                  Taxation for the Company which would not otherwise have
                  arisen, then, as and when the liability of the Company to make
                  an actual payment of or in respect of Taxation is reduced by
                  reason of that Relief or, in the case of a repayment of
                  Taxation, as and when the repayment is received, the amount by
                  which the liability is reduced or the amount of the repayment
                  (the RELEVANT AMOUNT) shall be dealt with as follows:

8.1.1             the Relevant Amount shall first be set off against any payment
                  then due from the Covenantors under this deed; and


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<PAGE>

8.1.2             to the extent that there is any excess, a refund shall be made
                  forthwith to the Covenantors of any previous payment or
                  payments made by the Covenantors under this deed and not
                  previously refunded under this paragraph up to the amount of
                  such excess, and

8.1.3             to the extent that the excess referred to in paragraph 8.1.2
                  is not exhausted under that paragraph, the remainder of the
                  excess shall be carried forward for set off against any future
                  payment or payments which becomes due from the Covenantors
                  under this deed.

8.2               If, at any time, the Purchaser or the Company become aware of
                  any Relief, repayment or excessive provision for taxation to
                  which paragraph 8.1 may apply, the Purchaser shall as soon as
                  reasonably practicable give full details in writing to the
                  Covenantors.

9.                PURCHASERS COVENANT

9.1               The Purchaser agrees with and undertakes to the Covenantors to
                  pay to the Covenantors an amount equal to any Taxation payable
                  by any of the Covenantors or any company controlled by any of
                  the Covenantors (other than the Company) arising as a result
                  of or in respect of any failure by the Company or the
                  Purchaser to pay any Taxation which is the primary liability
                  of the Company and/or the Purchaser save where such Taxation
                  gives rise to a liability of the Covenantors under clause 3
                  above which the Covenantors have not satisfied.


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<PAGE>

9.2               The provisions of paragraphs 6 and 7 shall apply to the
                  covenant in paragraph 9.1 as they apply to the covenants in
                  paragraph 3 mutatis mutandis.

10.               REDUCTION OF PURCHASE PRICE

                  Any amounts payable pursuant to this deed shall be deemed to
                  constitute a reduction in the Consideration.

11.               ASSIGNMENT

                  The provisions of clause 12.4 of the Agreement shall apply
                  equally to this deed.

12.               NOTICES

                  The provisions of clause 15 and 16.2 of the Agreement shall
                  apply equally to this deed.

13.               LAW

                  The provisions of clause 16 of the Agreement shall apply
                  equally to this deed.


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<PAGE>

                                    SCHEDULE

                                   COVENANTORS

Anthony Peter Fendick Cook
63 St Annes Road
Leeds
West Yorkshire
LS6  3NY

Keith Anthony Harrington
9 Rochester Grove
Hazelgrove
Stockport
Cheshire
SK7 4JD

Julian Hayward
18 Nursery Grove
Alwoodly
Leeds
West Yorkshire
LS17 7AL

Glen Anthony Hopkinson
"Stoneycroft"
27 Croftway
Sherburn-in-Elmet
Leeds
North Yorkshire
LS25 6BW

Paul Leon Marinus Hoyle
Holme Farm Cottage
Wothersome
Wetherby
West Yorkshire
LS23 6NA

Agnes Julienne Dietlinde Katritzky
Revocable Trust
1221 South West
21 Street
Gainsville
Florida 32601
USA


                                      122

<PAGE>

K B (CI) Nominees Ltd
West Centre
St Helier
Jersey

University of Leeds
Innovations Ltd
175 Woodhouse Lane
Leeds
West Yorkshire
LS2 3AR


                                      123

<PAGE>

SIGNED AS A DEED by                          )

ANTHONY PETER FENDICK COOK                   ) /s/ ANTHONY PETER FENDICK COOK

in the presence of:-                         )





SIGNED AS A DEED by                          )

KEITH ANTHONY HARRINGTON                     ) /s/ KEITH ANTHONY HARRINGTON

in the presence of:-                         )





SIGNED AS A DEED by                          )

JULIAN HAYWARD                               ) /s/ JULIAN HAYWARD

in the presence of:-                         )





SIGNED AS A DEED by                          )

GLEN ANTHONY HOPKINSON                       ) /s/ GLEN ANTHONY HOPKINSON

in the presence of:-                         )





SIGNED AS A DEED by                          )

PAUL LEON MARINUS HOYLE                      ) /s/ PAUL LEON MARINUS HOYLE

in the presence of:-                         )


                                      124
<PAGE>

SIGNED AS A DEED by the trustee(s) of        )

AGNES JULIENNE DIETLINDE                     ) /s/ AGNES JULIENNE DIETLINDE

KATRITZKY REVOCABLE TRUST                    ) KATRITZKY REVOCABLE TRUST

in the presence of:-                         )





EXECUTED AS A DEED by                        )

K B (CI) NOMINEES LTD                        ) /s/ K B (CI) NOMINEES LTD

acting by                                    )
                                             )
and                                          )
                                             )
Director:

Director/Secretary:


EXECUTED AS A DEED by                        )

UNIVERSITY OF LEEDS                          ) /s/ UNIVERSITY OF LEEDS

INNOVATIONS LTD                              ) /s/ INNOVATIONS LTD

acting by                                    )
                                             )
and                                          )
                                             )
Director:

Director/Secretary:


                                      125

<PAGE>

EXECUTED AS A DEED by                        )

PHARMACOPEIA, INC.                           ) PHARMACOPEIA

acting by                                    ) /s/ JOSEPH A. MOLLECA
                                             )

President and Chief Executive Officer:


                                      126

<PAGE>


EXECUTED AS A DEED by
PHARMACOPEIA INC.
acting by

/s/ JOSEPH A. MOLLICA
- -------------------------------------
President and Chief Executive Officer




EXECUTED AS A DEED by
KB(CI) NOMINEES LIMITED
acting by

- ---------------------------------------       -----------------------------
Director                                      Director



EXECUTED AS A DEED by
UNIVERSITY OF LEEDS INNOVATIONS LIMITED
acting by

- ---------------------------------------       -----------------------------
Director                                      Director



EXECUTED AS A DEED by
Or for and on behalf of                   )



ANTHONY PETER FENDICK COOK                      /s/ ANTHONY PETER FENDICK COOK
                                                --------------------------------
                                                                        APF Cook


KEITH ANTHONY HARRINGTON                        /s/ KEITH ANTHONY HARRINGTON
                                                --------------------------------
                                                                   KA Harrington


JULIAN HAYWARD                                  /s/ JULIAN HAYWARD
                                                --------------------------------
                                                                       J Hayward


GLEN A. HOPKINSON                               /s/ GLEN A. HOPKINSON
                                                --------------------------------
                                                                    GA Hopkinson


                                      127

<PAGE>


PAUL LEON MARINUS HOYLE                         /s/ PAUL L. M. HOYLE
                                                --------------------------------
                                                                       PLM Hoyle


AGNES JULIENNE DIETLINDE
KATRITZKY TRUST                                 /s/ AGNES J. DIETLINDE
                                                --------------------------------
                                                                         Trustee

in the presence of this witness
- -------------------------------                 Witness full name
- -------------------------------
- -------------------------------                 Address
- -------------------------------
- -------------------------------
- -------------------------------                 Occupation


                                      128


<PAGE>

                                     EX-99.1

                      PRESS RELEASE DATED FEBRUARY 29,2000


<PAGE>

                                                                    Exhibit 99.1

                    [On the letterhead of Pharmacopeia, Inc.]



FOR IMMEDIATE RELEASE

CONTACTS:

Cynthia A. Rossi
Investor Relations
Pharmacopeia, Inc.
(609) 452-3600
[email protected]


PHARMACOPEIA ENHANCES CHEMINFORMATICS POSITION THROUGH
ACQUISITION OF SYNOPSYS SCIENTIFIC SYSTEMS

Princeton, NJ, February 29, 2000 - Pharmacopeia, Inc. (Nasdaq: PCOP) today
announced that it has acquired all of the outstanding stock of privately-held
Synopsys Scientific Systems Ltd. ("Synopsys") in a transaction valued at
approximately $25 million, consisting primarily of cash.

Synopsys provides high-quality scientific solutions, including chemical database
software, chemical data content and systems integration services, to the
pharmaceutical, biotechnology, fine-chemical, and agrochemical industries.
Synopsys' products and services are used worldwide by research scientists and
information professionals for the design and development of pharmaceuticals and
fine chemicals. Synopsys' software and databases provide customers with timely
access to important sources of chemical information. Component-based software
tools offered by Synopsys allow users to store, search, and analyze chemical
data using industry standard applications from companies such as Oracle and
Microsoft. Customers of Synopsys' systems integration services receive
assistance in the implementation of complete integrated solutions for their
chemical information needs.

As a result of this acquisition, Pharmacopeia has gained a cheminformatics
technology base, its supporting intellectual property, and more than 30 highly
skilled scientists and software and database developers. Synopsys is a
profitable company and generates current annual revenues of approximately $3
million. Excluding the effects of in-process research and development write-offs
and goodwill amortization, Pharmacopeia expects the acquisition of Synopsys to
have a neutral effect on earnings per share in 2000 and an accretive effect
thereafter.

"Pharmacopeia's strategy is to offer an integrated set of science and
technology-based products and services that enable our life science customers to
accelerate the drug discovery process from target identification to human
clinical trials," said Joseph A. Mollica, Ph.D., Chairman,


<PAGE>

President, and CEO of Pharmacopeia. "The acquisition of Synopsys is a critical
step in the execution of this strategy. With the concurrent explosion in the
number of chemical compounds available for drug discovery and targets emerging
from genomics, an enormous amount of chemical data is being generated. Synopsys'
products and services specifically address this issue by allowing researchers to
store, search, access, and analyze this important data."

"With the acquisition of Synopsys, we gain enhanced expertise in the important
area of cheminformatics, augmenting the high-quality portfolio of products and
services we currently offer," continued Dr. Mollica. "Not only will this
acquisition benefit our life sciences customers, it could support our on-going
deployment of informatics technology to service chemists, formulators, and
materials scientists in the chemicals industry. The addition of Synopsys
augments our existing research and development capabilities and we're looking
forward to combining our various strengths, resources and talents to more
effectively assist our customers in their drug discovery efforts."

"Recognizing the trend towards component-based software and Internet
technologies, we formed Synopsys to address the critical need for the management
of chemical information emerging from the research and development process,"
said Dr. Glen A. Hopkinson, Managing Director of Synopsys. "Combining with a
company such as Pharmacopeia creates great opportunity because we share many of
the same customers and our technology offerings are complementary. As Synopsys'
products and services benefit from an integration with Pharmacopeia's products
and services, and also from their global sales force, I am optimistic that we
can contribute to the company's future growth and together we can provide an
integrated informatics platform to support drug discovery."

Synopsys is now a wholly owned subsidiary of Pharmacopeia and will be integrated
into Pharmacopeia's Life Sciences group. This group offers science and
technology-based products and services that enable pharmaceutical and
biotechnology companies to discover drugs more quickly and less expensively.
Glen Hopkinson, Managing Director of Synopsys, has been named Vice President of
Pharmacopeia's Life Sciences Cheminformatics Division and will report to Saiid
Zarrabian, Pharmacopeia's Chief Operating Officer. Synopsys is based in Leeds,
United Kingdom.

Pharmacopeia (http://www.pcop.com) is a leader in enabling science and
technology that accelerates drug discovery and chemical development.
Pharmacopeia's drug discovery services segment integrates informatics, small
molecule combinatorial chemistry, and high-throughput screening. Using ECLiPSTM,
its proprietary combinatorial chemistry technology, Pharmacopeia has generated
more than 6 million diverse, small molecules. Pharmacopeia tests these molecules
using state-of-the-art high-throughput screening. Pharmacopeia's software
segment, which includes MSI (http://www.msi.com) and Synopsys
(http://www.synopsys.co.uk), develops and commercializes molecular modeling,
simulation, and informatics software and services. The drug discovery services
and software technologies are integrated to support: 1) software sales and
systems integration services for pharmaceutical, biotechnology, and chemical
research, and 2) lead identification and optimization services for drug
discovery. Pharmacopeia employs


<PAGE>

approximately 550 people and is headquartered in Princeton, NJ. Major regional
operations are in San Diego, CA, Cambridge, England, and Tokyo, Japan.

                                       ###

Except for the historical information contained herein, this statement may
contain projections or other forward-looking statements regarding future events
or the future financial performance of the Company. Pharmacopeia wishes to
caution you that such statements are just predictions and that actual events or
results may differ materially. Pharmacopeia refers you to the documents that it
files from time to time with the Securities and Exchange Commission,
specifically the Company's last filed Annual Report on Form 10-K and subsequent
Quarterly Reports on Form 10-Q. These documents contain and identify important
factors, including risk factors that could cause the actual results to differ
materially from those contained in the projections or forward-looking
statements.


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