<PAGE> PAGE 1
000 B000000 12/31/98
000 C000000 0001002624
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 3.0.a
000 J000000 A
001 A000000 T. ROWE PRICE HEALTH SCIENCES FUND, INC
001 B000000 811-07381
001 C000000 4103452000
002 A000000 100 EAST PRATT STREET
002 B000000 BALTIMORE
002 C000000 MD
002 D010000 21202
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
008 A000001 T. ROWE PRICE ASSOCIATES, INC
008 B000001 A
008 C000001 801-856
008 D010001 BALTIMORE
008 D020001 MD
008 D030001 21202
011 A000001 T. ROWE PRICE INVESTMENT SERVICES, INC.
011 B000001 8-25130
011 C010001 BALTIMORE
011 C020001 MD
011 C030001 21202
012 A000001 T. ROWE PRICE SERVICES, INC.
012 B000001 84-1079
012 C010001 BALTIMORE
012 C020001 MD
012 C030001 21202
013 A000001 PRICEWATERHOUSECOOPERS LLP
013 B010001 BALTIMORE
013 B020001 MD
<PAGE> PAGE 2
013 B030001 21202
014 A000001 T. ROWE PRICE INVESTMENT SERVICES, INC
014 B000001 8-25130
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02110
015 E010001 X
015 A000002 THE CHASE MANHATTEN BANK, NA
015 B000002 C
015 C010002 LONDON
015 D010002 ENGLAND
015 D020002 ECZP 2HD
015 E040002 X
018 000000 Y
019 A000000 Y
019 B000000 87
019 C000000 TROWEPRICE
020 A000001 MORGAN STANLEY
020 B000001 13-2655998
020 C000001 39
020 A000002 BT ALEX BROWN
020 B000002 13-3311934
020 C000002 20
020 A000003 GOLDMAN SACHS
020 B000003 13-5108880
020 C000003 19
020 A000004 MERRILL LYNCH
020 B000004 13-5674085
020 C000004 15
020 A000005 PAINE WEBBER GROUP
020 B000005 13-2638166
020 C000005 15
020 A000006 SG COWEN SECURITIES
020 B000006 13-5616116
020 C000006 13
020 A000007 LEHMAN BROTHERS
020 B000007 13-2518466
020 C000007 13
020 A000008 BRIDGE TRADING
020 B000008 43-1450530
020 C000008 12
020 A000009 DRESDNER KLEINWORT BENSON N.A.
020 B000009 13-3894311
020 C000009 11
020 A000010 DAIN RAUCHER
020 B000010 41-1416330
020 C000010 10
021 000000 310
022 A000001 AB WATLEY
<PAGE> PAGE 3
022 B000001 11-1898284
022 C000001 0
022 D000001 1177
022 A000002 PIPER JAFFRAY
022 B000002 41-0953246
022 C000002 12952
022 D000002 11923
022 A000003 MORGAN STANLEY
022 B000003 13-2655998
022 C000003 9625
022 D000003 14839
022 A000004 NATIONSBANC MONTGOMERY SECURITIES
022 B000004 56-1684171
022 C000004 7638
022 D000004 13713
022 A000005 CIBC OPPENHEIMER & CO.
022 B000005 13-2798343
022 C000005 3443
022 D000005 10060
022 A000006 DONALDSON LUFKIN & JENRETTE
022 B000006 13-2741729
022 C000006 5123
022 D000006 7850
022 A000007 GOLDMAN SACHS
022 B000007 13-5108880
022 C000007 7547
022 D000007 5197
022 A000008 C.S. FIRST BOSTON
022 B000008 13-5659485
022 C000008 7725
022 D000008 3101
022 A000009 MERRILL LYNCH
022 B000009 13-5674085
022 C000009 7923
022 D000009 2138
022 A000010 SALOMON SMITH BARNEY
022 B000010 13-1912900
022 C000010 2814
022 D000010 7137
023 C000000 96791
023 D000000 123336
024 000000 N
025 D000001 0
025 D000002 0
025 D000003 0
025 D000004 0
025 D000005 0
025 D000006 0
025 D000007 0
025 D000008 0
026 A000000 N
<PAGE> PAGE 4
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 Y
027 000000 Y
028 A010000 7161
028 A020000 0
028 A030000 0
028 A040000 12008
028 B010000 6459
028 B020000 0
028 B030000 0
028 B040000 13182
028 C010000 6805
028 C020000 0
028 C030000 0
028 C040000 6553
028 D010000 5916
028 D020000 0
028 D030000 0
028 D040000 8233
028 E010000 6657
028 E020000 0
028 E030000 0
028 E040000 6937
028 F010000 10844
028 F020000 12127
028 F030000 0
028 F040000 10481
028 G010000 43842
028 G020000 12127
028 G030000 0
028 G040000 57394
028 H000000 0
029 000000 N
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
034 000000 N
035 000000 0
036 B000000 0
037 000000 N
038 000000 0
<PAGE> PAGE 5
039 000000 N
040 000000 N
041 000000 N
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 N
048 000000 0.000
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 Y
053 A000000 N
054 A000000 N
054 B000000 N
054 C000000 N
054 D000000 Y
054 E000000 Y
054 F000000 Y
054 G000000 N
<PAGE> PAGE 6
054 H000000 N
054 I000000 N
054 J000000 N
054 K000000 N
054 L000000 N
054 M000000 N
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 2500
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
063 A000000 0
063 B000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 Y
066 D000000 N
066 E000000 N
066 F000000 N
066 G000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
<PAGE> PAGE 7
070 B020000 N
070 C010000 N
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 N
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 N
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 N
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 N
070 R020000 N
071 A000000 230701
071 B000000 248335
071 C000000 269116
071 D000000 86
072 A000000 12
072 B000000 1218
072 C000000 1392
072 D000000 0
072 E000000 0
072 F000000 1926
072 G000000 0
072 H000000 0
072 I000000 1039
072 J000000 34
072 K000000 47
072 L000000 72
072 M000000 7
072 N000000 89
<PAGE> PAGE 8
072 O000000 0
072 P000000 0
072 Q000000 65
072 R000000 11
072 S000000 2
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 41
072 X000000 3333
072 Y000000 0
072 Z000000 -723
072AA000000 14931
072BB000000 0
072CC010000 43907
072CC020000 0
072DD010000 0
072DD020000 0
072EE000000 12484
073 A010000 0.0000
073 A020000 0.0000
073 B000000 0.6600
073 C000000 0.0000
074 A000000 0
074 B000000 0
074 C000000 26052
074 D000000 0
074 E000000 0
074 F000000 300952
074 G000000 0
074 H000000 0
074 I000000 0
074 J000000 1323
074 K000000 0
074 L000000 1212
074 M000000 12
074 N000000 329551
074 O000000 11475
074 P000000 95
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 1408
074 S000000 0
074 T000000 316573
074 U010000 19771
074 U020000 0
074 V010000 16.01
074 V020000 0.00
074 W000000 0.0000
<PAGE> PAGE 9
074 X000000 33784
074 Y000000 0
075 A000000 286656
075 B000000 0
076 000000 0.00
077 A000000 Y
077 B000000 Y
078 000000 N
080 A000000 ICI MUTUAL INSURANCE COMPANY
080 C000000 60000
081 A000000 Y
081 B000000 125
082 A000000 N
082 B000000 0
083 A000000 N
083 B000000 0
084 A000000 N
084 B000000 0
085 A000000 Y
085 B000000 N
086 A010000 0
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
SIGNATURE JAMES RIEPE
TITLE VICE-PRESIDENT
<TABLE> <S> <C>
<ARTICLE> 6
<CIK> 0001002624
<NAME> T. ROWE PRICE HEALTH SCIENCES FUND, INC.
<S> <C>
<PERIOD-TYPE> YEAR
<FISCAL-YEAR-END> DEC-31-1998
<PERIOD-END> DEC-31-1998
<INVESTMENTS-AT-COST> 261897
<INVESTMENTS-AT-VALUE> 327004
<RECEIVABLES> 2547
<ASSETS-OTHER> 0
<OTHER-ITEMS-ASSETS> 0
<TOTAL-ASSETS> 329551
<PAYABLE-FOR-SECURITIES> 11475
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 1503
<TOTAL-LIABILITIES> 12978
<SENIOR-EQUITY> 0
<PAID-IN-CAPITAL-COMMON> 242159
<SHARES-COMMON-STOCK> 19771
<SHARES-COMMON-PRIOR> 19868
<ACCUMULATED-NII-CURRENT> 0
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 9307
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 65107
<NET-ASSETS> 316573
<DIVIDEND-INCOME> 1392
<INTEREST-INCOME> 1218
<OTHER-INCOME> 0
<EXPENSES-NET> 3333
<NET-INVESTMENT-INCOME> (723)
<REALIZED-GAINS-CURRENT> 14931
<APPREC-INCREASE-CURRENT> 43907
<NET-CHANGE-FROM-OPS> 58115
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 0
<DISTRIBUTIONS-OF-GAINS> (12484)
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 7046
<NUMBER-OF-SHARES-REDEEMED> (7954)
<SHARES-REINVESTED> 811
<NET-CHANGE-IN-ASSETS> 45222
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> 7549
<OVERDISTRIB-NII-PRIOR> 0
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 1926
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 3333
<AVERAGE-NET-ASSETS> 286656
<PER-SHARE-NAV-BEGIN> 13.66
<PER-SHARE-NII> (0.04)
<PER-SHARE-GAIN-APPREC> 3.05
<PER-SHARE-DIVIDEND> 0
<PER-SHARE-DISTRIBUTIONS> (0.66)
<RETURNS-OF-CAPITAL> 0
<PER-SHARE-NAV-END> 16.01
<EXPENSE-RATIO> 1.16
<AVG-DEBT-OUTSTANDING> 0
<AVG-DEBT-PER-SHARE> 0
</TABLE>
