MILLENNIUM PHARMACEUTICALS INC
8-K, 1997-02-20
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 --------------


                                    FORM 8-K


                                 Current Report
                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934



       Date of Report (Date of earliest event reported): February 10, 1997


                        Millennium Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)


                                    Delaware
- --------------------------------------------------------------------------------
                 (State or other jurisdiction of incorporation)


                0-28494                                   04-3177038
         ------------------------              ---------------------------------
         (Commission File Number)              (IRS Employer Identification No.)


640 Memorial Drive, Cambridge, Massachusetts                 02139
- --------------------------------------------------------------------------------
 (Address of principal executive offices)                  (Zip Code)



       Registrant's telephone number, including area code: (617) 679-7000
                                                           --------------
- --------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)


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         Item 2.   ACQUISITION OF DISPOSITION OF ASSETS
         ------

              On February 10, 1997, Millennium Pharmaceuticals, Inc.
         ("Millennium") acquired (the "Acquisition") all of the issued capital
         stock of ChemGenics Pharmaceuticals Inc., a Delaware corporation
         ("ChemGenics"), by means of a merger of CPI Acquisition Corp., a
         Delaware corporation and a wholly-owned subsidiary of Millennium (the
         "Transitory Subsidiary"), with and into ChemGenics. The Acquisition
         took place pursuant to the terms of an Agreement and Plan of Merger,
         dated as of January 20, 1997 (the "Merger Agreement"), among
         Millennium, the Transitory Subsidiary and ChemGenics. Under the terms
         of the Merger Agreement, the stockholders of ChemGenics received an
         aggregate of 4,783,688 shares of Millennium's Common Stock, $.001 par
         value ("Millennium Common Stock") in exchange for their capital stock.
         In addition, each outstanding option to purchase a share of Common
         Stock, $.001 par value of ChemGenics ("ChemGenics Common Stock") was
         exchanged for an option to purchase 0.2374 shares of Millennium Common
         Stock at an exercise price equal to the exercise price prior to the
         Acquisition divided by 0.2374. Warrants to purchase an aggregate of
         177,038 shares of Series A Convertible Preferred Stock, $.01 par value,
         of ChemGenics and a warrant to purchase up to 4,896,335 shares of
         ChemGenics Common Stock were surrendered for payments of $511,000 and
         $1,000,000, respectively. The consideration for the capital stock,
         options and warrants of ChemGenics was determined by arm's length
         negotiation between the parties as to the fair market value of
         ChemGenics as a going concern.

              ChemGenics is located in Cambridge, Massachusetts and is in the
         business of antifungal and antibacterial drug discovery.

         Item 7.   FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND 
         ------    EXHIBITS

              (a)  Financial Statements of Business Acquired.
                   -----------------------------------------

              It is impracticable to provide the required financial statements
         at the time of the filing of this Current Report on Form 8-K. Required
         financial statements will be filed on a Form 8-K/A as soon as
         practicable after the date hereof, but not later than April 21, 1997.

              (b)  Pro Forma Financial Information.
                   -------------------------------

              It is impracticable to provide the required financial statements
         at the time of the filing of this Current Report on Form 8-K. Required
         pro forma financial statements will be filed on a Form 8-K/A as soon as
         practicable after the date hereof, but not later than April 21, 1997.

              (c)  Exhibits.
                   --------

              See Exhibit Index attached hereto.

<PAGE>   3




                                     SIGNATURES



              Pursuant to the requirements of the Securities Exchange Act of
         1934, the registrant has duly caused this report to be signed on its
         behalf by the undersigned hereunto duly authorized.



                                       MILLENNIUM PHARMACEUTICALS, INC.
                                       (Registrant)



         Date:  February 20, 1997      By: /s/ Mark J. Levin
                                           -------------------------------------
                                           Mark J. Levin
                                           Chief Executive Officer


<PAGE>   4



                                   EXHIBIT INDEX
                                   -------------


         (2)       Agreement and Plan of Merger dated January 20, 1997 by and
                   among Millennium Pharmaceuticals, Inc., CPI Acquisition Corp.
                   and ChemGenics Pharmaceuticals Inc. Millennium will furnish
                   supplementally a copy of any omitted Exhibit or Schedule to
                   the Securities and Exchange Commission upon request.

         (99.1)    Press Release dated January 20, 1997.

         (99.2)    Press Release dated February 11, 1997.



<PAGE>   1
                                                                       EXHIBIT 2

                            AGREEMENT AND PLAN OF MERGER


              Agreement entered into as of January 20, 1997 by and among
         Millennium Pharmaceuticals, Inc., a Delaware corporation (the "Buyer"),
         CPI Acquisition Corp., a Delaware corporation and a wholly-owned
         subsidiary of the Buyer (the "Transitory Subsidiary"), and ChemGenics
         Pharmaceuticals Inc., a Delaware corporation (the "Company"). The
         Buyer, the Transitory Subsidiary and the Company are referred to
         collectively herein as the "Parties."

              This Agreement contemplates a tax-free merger of the Transitory
         Subsidiary into the Company. In such merger, the stockholders of the
         Company will receive capital stock of the Buyer in exchange for their
         capital stock of the Company.

              Now, therefore, in consideration of the representations,
         warranties and covenants herein contained, the Parties agree as
         follows.

                                      ARTICLE I

                                     THE MERGER

              1.1 THE MERGER. Upon and subject to the terms and conditions of
         this Agreement, the Transitory Subsidiary shall merge with and into the
         Company (with such merger referred to herein as the "Merger") at the
         Effective Time (as defined below). From and after the Effective Time,
         the separate corporate existence of the Transitory Subsidiary shall
         cease and the Company shall continue as the surviving corporation in
         the Merger (the "Surviving Corporation"). The "Effective Time" shall be
         the time at which the Company and the Transitory Subsidiary file the
         certificate of merger or other appropriate documents prepared and
         executed in accordance with the relevant provisions of the Delaware
         General Corporation Law (the "Certificate of Merger") with the
         Secretary of State of the State of Delaware. The Merger shall have the
         effects set forth in Section 259 of the Delaware General Corporation
         Law.

              1.2 THE CLOSING. The closing of the transactions contemplated by
         this Agreement (the "Closing") shall take place at the offices of Hale
         and Dorr LLP, 60 State Street, Boston MA, commencing at 9:00 a.m. local
         time as soon as practicable, and in any event no later than three
         business days, after the satisfaction or waiver of all conditions set
         forth in Article V hereof to the obligations of the Parties to
         consummate the transactions contemplated hereby (the "Closing Date").





<PAGE>   2



              1.3 ACTIONS AT THE CLOSING. At the Closing, (a) the Company shall
         deliver to the Buyer and the Transitory Subsidiary the various
         certificates, instruments and documents referred to in Section 5.2, (b)
         the Buyer and the Transitory Subsidiary shall deliver to the Company
         the various certificates, instruments and documents referred to in
         Section 5.3, (c) the Company and the Transitory Subsidiary shall file
         with the Secretary of State of the State of Delaware the Certificate of
         Merger, (d) each Stockholder of record of the Company (the "Company
         Stockholders") may deliver to the Buyer for cancellation such Company
         Stockholder's certificate or certificates representing Company Shares,
         (e) the Buyer shall deliver the appropriate number of Merger Shares (as
         defined below) to each Company Stockholder who shall have delivered its
         certificate or certificates representing Company Shares pursuant to the
         foregoing clause (d), and (f) the Buyer shall deliver a certificate for
         the Merger Shares, other than those delivered pursuant to the foregoing
         clause (e), to a bank or trust company appointed by the Buyer to act as
         the exchange agent (the "Exchange Agent") in accordance with Section
         1.7.

              1.4 ADDITIONAL ACTION. The Surviving Corporation may, at any time
         after the Effective Time, take any action, including executing and
         delivering any document, in the name and on behalf of either the
         Company or the Transitory Subsidiary, in order to consummate the
         transactions contemplated by this Agreement.

              1.5 CONVERSION OF SHARES. At the Effective Time, by virtue of the
         Merger and without any action on the part of any Party or the holder of
         any of the following securities:

                   (a) Each share of common stock, $.001 par value per share
         (the "Company Common Stock"), and of convertible preferred stock, $.01
         par value per share (the "Company Convertible Preferred Stock"), of the
         Company (collectively, "Company Shares") issued and outstanding
         immediately prior to the Effective Time (other than Company Shares
         owned beneficially by the Buyer or the Transitory Subsidiary,
         Dissenting Shares (as defined below) and Company Shares held in the
         Company's treasury) shall be converted into and shall represent the
         right to receive such number of shares of common stock, $.001 par value
         per share, of the Buyer ("Buyer Common Stock") as is equal to the
         Conversion Ratio. The "Conversion Ratio" shall initially be equal to a
         fraction expressed as a decimal carried out to four places, the
         numerator of which is 4,782,825 and the denominator of which is the
         total number of issued and outstanding Company Shares at the Effective
         Time. The Conversion Ratio shall be subject to equitable adjustment in
         the event of any stock split, stock dividend, reverse stock split or
         similar event affecting the Buyer Common Stock between the date of this
         Agreement and the Effective Time.



                                         -2-




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         The shares of Buyer Common Stock issued pursuant to this Section 1.5(a)
         are referred to herein as the "Merger Shares."

                   (b) Each Company Share held in the Company's treasury
         immediately prior to the Effective Time and each Company Share owned
         beneficially by the Buyer or the Transitory Subsidiary shall be
         cancelled and retired without payment of any consideration therefor.

                   (c) Each share of common stock, $.001 par value per share, of
         the Transitory Subsidiary issued and outstanding immediately prior to
         the Effective Time shall be converted into and thereafter evidence one
         share of common stock, $.001 par value per share, of the Surviving
         Corporation.

              1.6  Dissenting Shares.
                   -----------------

                   (a) For purposes of this Agreement, "Dissenting Shares" means
         Company Shares held as of the Effective Time by a Company Stockholder
         who has not voted such Company Shares in favor of (or consented by
         written action to) the adoption of this Agreement and approval of the
         Merger and with respect to which appraisal shall have been duly
         demanded and perfected in accordance with Section 262 of the Delaware
         General Corporation Law and not effectively withdrawn or forfeited.
         Dissenting Shares shall not be converted into or represent the right to
         receive Merger Shares, unless such Company Stockholder shall have
         forfeited his right to appraisal under the Delaware General Corporation
         Law or withdrawn, with the consent of the Company, his demand for
         appraisal. If such Company Stockholder has so forfeited or withdrawn
         his right to appraisal of Dissenting Shares, then as of the occurrence
         of such event, such holder's Dissenting Shares shall cease to be
         Dissenting Shares and shall be converted into and represent the right
         to receive the Merger Shares issuable in respect of such Company Shares
         pursuant to Section 1.5(a).

                   (b) The Company shall give the Buyer (i) prompt notice of any
         written demands for appraisal of any Company Shares, withdrawals of
         such demands, and any other instruments that relate to such demands
         received by the Company and (ii) the opportunity to direct all
         negotiations and proceedings with respect to demands for appraisal
         under the Delaware General Corporation Law. The Company shall not,
         except with the prior written consent of the Buyer, make any payment
         with respect to any demands for appraisal of Company Shares or offer to
         settle or settle any such demands.



                                         -3-




<PAGE>   4


              1.7  Exchange of Shares.
                   ------------------

                   (a) Prior to the Effective Time, the Buyer shall appoint the
         Exchange Agent to effect the exchange for the Merger Shares of
         certificates that, immediately prior to the Effective Time, represented
         Company Shares converted into Merger Shares pursuant to Section 1.5
         (including any Company Shares referred to in the last sentence of
         Section 1.6(a)) ("Certificates"). On the Closing Date, or as soon
         thereafter as reasonably practicable, the Buyer shall deliver to the
         Exchange Agent, in trust for the benefit of holders of Certificates, a
         stock certificate (issued in the name of the Exchange Agent or its
         nominee) representing the Merger Shares, as described in Section
         1.5(a), other than those issued pursuant to Section 1.3(e) hereof. As
         soon as practicable after the Effective Time, the Buyer shall cause the
         Exchange Agent to send a notice and a transmittal form to each holder
         of a Certificate (other than those surrendered and exchanged at the
         Closing) advising such holder of the effectiveness of the Merger and
         the procedure for surrendering to the Exchange Agent such Certificate
         in exchange for the Merger Shares issuable pursuant to Section 1.5(a).
         Each holder of a Certificate, upon proper surrender thereof to the
         Exchange Agent in accordance with the instructions in such notice (or
         surrender at Closing pursuant to Section 1.3(e) hereof), shall be
         entitled to receive in exchange therefor (subject to any taxes required
         to be withheld) the Merger Shares issuable pursuant to Section 1.5(a).
         Until properly surrendered, each such Certificate shall be deemed for
         all purposes to evidence only the right to receive the Merger Shares
         issuable pursuant to Section 1.5(a). Holders of Certificates shall not
         be entitled to receive certificates for the Merger Shares to which they
         would otherwise be entitled until such Certificates are properly
         surrendered.

                   (b) If any Merger Shares are to be issued in the name of a
         person other than the person in whose name the Certificate surrendered
         in exchange therefor is registered, it shall be a condition to the
         issuance of such Merger Shares that (i) the Certificate so surrendered
         shall be transferable, and shall be properly assigned, endorsed or
         accompanied by appropriate stock powers, (ii) such transfer shall
         otherwise be proper and (iii) the person requesting such transfer shall
         pay to the Exchange Agent any transfer or other taxes payable by reason
         of the foregoing or establish to the satisfaction of the Exchange Agent
         that such taxes have been paid or are not required to be paid.
         Notwithstanding the foregoing, neither the Exchange Agent nor any Party
         shall be liable to a holder of Company Shares for any Merger Shares
         issuable to such holder pursuant to Section 1.5(a) that are delivered
         to a public official pursuant to applicable abandoned property, escheat
         or similar laws.




                                         -4-




<PAGE>   5



                   (c) In the event any Certificate shall have been lost, stolen
         or destroyed, upon the making of an affidavit of that fact by the
         person claiming such Certificate to be lost, stolen or destroyed, the
         Buyer shall issue in exchange for such lost, stolen or destroyed
         Certificate the Merger Shares issuable in exchange therefor pursuant to
         Section 1.5(a). The Board of Directors of the Buyer may, in its
         reasonable discretion and as a condition precedent to the issuance
         thereof, require the owner of such lost, stolen or destroyed
         Certificate to give the Buyer a bond in such sum as it may direct as
         indemnity against any claim that may be made against the Buyer with
         respect to the Certificate alleged to have been lost, stolen or
         destroyed.

                   (d) Promptly following the date which is six months after the
         Closing Date, the Exchange Agent shall return to the Buyer all Merger
         Shares in its possession, and the Exchange Agent's duties shall
         terminate. Thereafter, each holder of a Certificate may surrender such
         Certificate to the Buyer and, subject to applicable abandoned property,
         escheat and similar laws, receive in exchange therefor the Merger
         Shares issuable with respect thereto pursuant to Section 1.5(a).

                   (e) Notwithstanding anything in this Section 1.7 to the
         contrary, if the number of Merger Shares to be delivered to the
         Exchange Agent as provided in Section 1.3(f) is less than 2,000,000
         shares, the Buyer need not appoint an Exchange Agent, but instead may
         itself perform all of the duties and obligations of the Exchange Agent
         provided for in this Agreement.
        
              1.8 DIVIDENDS. No dividends or other distributions that are
         payable to the holders of record of Buyer Common Stock as of a date on
         or after the Closing Date shall be paid to former Company Stockholders
         entitled by reason of the Merger to receive Merger Shares until such
         holders surrender their Certificates in accordance with Section 1.7.
         Upon such surrender, the Buyer shall pay or deliver to the persons in
         whose name the certificates representing such Merger Shares are issued
         any dividends or other distributions that are payable to the holders of
         record of Buyer Common Stock as of a date on or after the Closing Date
         and which were paid or delivered between the Effective Time and the
         time of such surrender; provided that no such person shall be entitled
         to receive any interest on such dividends or other distributions.

              1.9 FRACTIONAL SHARES. No certificates or script representing
         fractional Merger Shares shall be issued to former Company Stockholders
         upon the surrender for exchange of Certificates, and such former
         Company Stockholders shall not be entitled to any voting rights, rights
         to receive any dividends or distributions or other rights as a
         stockholder of the Buyer with respect to any fractional Merger Shares
         that would otherwise be



                                         -5-



<PAGE>   6



         issued to such former Company Stockholders. In lieu of any fractional
         Merger Shares that would otherwise be issued, each former Company
         Stockholder that would have been entitled to receive a fractional
         Merger Share shall, upon proper surrender of such person's
         Certificates, receive such whole number of Merger Shares as is equal to
         the precise number of Merger Shares to which such person would be
         entitled, rounded up or down to the nearest whole number.

             1.10  Options and Warrants.
                   --------------------

                   (a) As of the Effective Time, all options to purchase Company
         Shares issued by the Company pursuant to its 1992 Employee, Director
         and Consultant Stock Option Plan ("Options"), whether vested or
         unvested, shall be assumed by the Buyer and shall be deemed to be
         Options granted pursuant to the Buyer's 1996 Equity Incentive Plan.
         Immediately after the Effective Time, each Option outstanding
         immediately prior to the Effective Time shall be deemed to constitute
         an option to acquire, on the same terms and conditions as were
         applicable under such Option at the Effective Time, such number of
         shares of Buyer Common Stock as is equal to the number of Company
         Shares subject to the unexercised portion of such Option multiplied by
         the Conversion Ratio (with any fraction resulting from such
         multiplication to be rounded up or down to the nearest whole number or,
         in the case of .5, to the nearest odd number). The exercise price per
         share of each such assumed Option shall be equal to the exercise price
         of such Option immediately prior to the Effective Time, divided by the
         Conversion Ratio. The term, exercisability, vesting schedule, status as
         an "incentive stock option" under Section 422 of the Internal Revenue
         Code of 1986 (as amended, the "Code"), if applicable, and all of the
         other terms of the Options shall otherwise remain unchanged. Each
         assumed Option shall be covered by an effective Registration Statement
         on Form S-8.

                   (b) As soon as practicable after the Effective Time, the
         Buyer or the Surviving Corporation shall deliver to the holders of
         Options appropriate notices setting forth such holders' rights pursuant
         to such Options, as amended by this Section 1.10, and the agreements
         evidencing such Options shall continue in effect on the same terms and
         conditions (subject to the amendments provided for in this Section 1.10
         and such notice).

                   (c) The Buyer shall take all corporate action necessary to
         reserve for issuance a sufficient number of shares of Buyer Common
         Stock for delivery upon exercise of the Options assumed in accordance
         with this Section 1.10.


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<PAGE>   7



                  (d) Subject to, and simultaneously with the occurrence of,
         the Closing, each of PerSeptive Biosystems, Inc. ("PBS"), and Comdisco,
         Inc. ("Comdisco"), shall surrender to the Company the respective
         warrants to purchase shares of capital stock of the Company
         ("Warrants") held by them in consideration of specified cash payments,
         all as provided in the respective letter agreements of even date
         herewith by and among the Buyer, the Company and PBS and by and among
         the Buyer, the Company and Comdisco.

             1.11 CERTIFICATE OF INCORPORATION. The Certificate of Incorporation
         of the Surviving Corporation shall be the same as the Certificate of
         Incorporation of the Transitory Subsidiary immediately prior to the
         Effective Time, except that the name of the corporation set forth
         therein shall be changed to the name of the Company.

             1.12 BY-LAWS. The By-laws of the Surviving Corporation shall be the
         same as the By-laws of the Transitory Subsidiary immediately prior to
         the Effective Time, except that the name of the corporation set forth
         therein shall be changed to the name of the Company.

             1.13 DIRECTORS AND OFFICERS. The directors of the Transitory
         Subsidiary shall become the directors of the Surviving Corporation as
         of the Effective Time. The officers of the Company shall remain as
         officers of the Surviving Corporation after the Effective Time,
         retaining their respective positions, except as specified by the Buyer
         pursuant to Section 5.2(g).

             1.14 NO FURTHER RIGHTS. From and after the Effective Time, no
         Company Shares shall be deemed to be outstanding, and holders of
         Certificates shall cease to have any rights with respect thereto,
         except as provided herein or by law.

             1.15 CLOSING OF TRANSFER BOOKS. At the Effective Time, the stock
         transfer books of the Company shall be closed and no transfer of
         Company Shares shall thereafter be made. If, after the Effective Time,
         Certificates are presented to the Surviving Corporation or the Exchange
         Agent, they shall be cancelled and exchanged for Merger Shares in
         accordance with Section 1.5(a), subject to applicable law in the case
         of Dissenting Shares.

             1.16 BOARD SEAT. The Company and the Buyer agree that the Company
         shall have the right to designate an individual to serve on the Board
         of Directors of the Buyer, such individual to be acceptable to the
         Buyer. The Buyer agrees to use reasonable efforts to cause such
         individual to be elected to the Board of Directors of the Buyer as soon
         as reasonably practicable after such individual is agreed upon by the
         Buyer and the Company. The




                                         -7-



<PAGE>   8




         Buyer shall have no further obligations under this Section 1.16 from
         and after December 31, 1997.

                                     ARTICLE II

                   REPRESENTATIONS AND WARRANTIES OF THE COMPANY

              The Company represents and warrants to the Buyer that the
         statements contained in this Article II are true and correct, except as
         set forth in the disclosure schedule attached hereto (the "Disclosure
         Schedule"). The Disclosure Schedule shall be initialed by the Parties
         and shall be arranged in paragraphs corresponding to the numbered and
         lettered paragraphs contained in this Article II, and the disclosures
         in any paragraph of the Disclosure Schedule shall be deemed to qualify
         other paragraphs in this Article II if it is reasonably clear from a
         reading of the disclosure that such disclosure is applicable to such
         other paragraphs.

              2.1 ORGANIZATION, QUALIFICATION AND CORPORATE POWER. The Company
         is a corporation duly organized, validly existing and in corporate and
         tax good standing under the laws of the state of its incorporation. The
         Company is duly qualified to conduct business and is in corporate and
         tax good standing under the laws of each jurisdiction in which the
         nature of its businesses or the ownership or leasing of its properties
         requires such qualification, other than any such failures to be so
         qualified or in corporate and tax good standing that do not, either
         individually or in the aggregate, have a material adverse effect on the
         assets, business, financial condition, results of operations or future
         prospects (other than prospects relating to the economy in general or
         the biotechnology or pharmaceutical industries in general) of the
         Company (a "Material Adverse Effect"). The Company has all requisite
         corporate power and authority to carry on the businesses in which it is
         engaged and to own and use the properties owned and used by it. The
         Company has furnished to the Buyer true and complete copies of its
         Certificate of Incorporation and By-laws, each as amended and as in
         effect on the date hereof. The Company is not in default under or in
         violation of any provision of its Certificate of Incorporation or
         By-laws.

              2.2 CAPITALIZATION. The authorized capital stock of the Company,
         as of the date of this Agreement, consists of (i) 13,441,667 shares of
         convertible preferred stock, $.01 par value per share, of which
         6,400,000 shares are designated Series A Convertible Preferred Stock,
         6,150,732 shares of which are issued and outstanding, 1,100,000 shares
         are designated Series B Convertible Preferred Stock, 1,063,366 shares
         of which are issued and outstanding, 775,000 shares are designated
         Series C



                                         -8-




<PAGE>   9



         Convertible Preferred Stock, 767,739 shares of which are issued and
         outstanding, 3,000,000 shares are designated Series D Convertible
         Preferred Stock, all of which are issued and outstanding, and 2,166,667
         shares are designated Series E Convertible Preferred Stock, 833,334
         shares of which are issued and outstanding, and (ii) 33,866,667 shares
         of common stock, $.001 par value per share, 8,335,079 shares of which
         are issued and outstanding and no shares of which are held in the
         treasury of the Company. Section 2.2 of the Disclosure Schedule sets
         forth as of the date of this Agreement, a complete and accurate list of
         (i) all stockholders of the Company, indicating (by class and series)
         the number of Company Shares held by each stockholder, and (ii) all
         holders of Options and Warrants, indicating (by class and series) the
         number of Company Shares subject to each Option and Warrant. All of the
         issued and outstanding Company Shares are, and all Company Shares that
         may be issued upon exercise of Options and Warrants will be, duly
         authorized, validly issued, fully paid, nonassessable and free of all
         preemptive rights. There are no outstanding or authorized options,
         warrants, rights, agreements or commitments to which the Company is a
         party or which are binding upon the Company providing for the issuance,
         disposition or acquisition of any of its capital stock, other than the
         Options and Warrants listed in Section 2.2 of the Disclosure Schedule.
         There are no outstanding or authorized stock appreciation, phantom
         stock or similar rights with respect to the Company. There are no
         agreements, voting trusts, proxies, or understandings with respect to
         the voting, or registration under the Securities Act of 1933, as
         amended (the "Securities Act"), of any Company Shares. To the knowledge
         of the Company, all of the issued and outstanding Company Shares were
         issued in compliance with applicable federal and state securities laws.

              2.3 AUTHORIZATION OF TRANSACTION. The Company has all requisite
         power and authority to execute and deliver this Agreement and to
         perform its obligations hereunder. The execution and delivery of this
         Agreement and, subject to the adoption of this Agreement and the
         approval of the Merger by (i) the holders of 60% of the issued and
         outstanding shares of Company Convertible Preferred Stock voting as a
         single class and (ii) the holders of a majority of the issued and
         outstanding shares of Company Common Stock and Company Convertible
         Preferred Stock, voting together as a single class (the "Requisite
         Stockholder Approval"), the performance by the Company of this
         Agreement and the consummation by the Company of the transactions
         contemplated hereby have been duly and validly authorized by all
         necessary corporate action on the part of the Company. This Agreement
         has been duly and validly executed and delivered by the Company and
         constitutes a valid and binding obligation of the Company, enforceable
         against the Company in accordance with its terms.




                                         -9-

<PAGE>   10

              2.4  NONCONTRAVENTION. Subject to compliance with the applicable
         requirements of the Securities Act and any applicable state securities
         laws, and the filing of the Certificate of Merger as required by the
         Delaware General Corporation Law, neither the execution and delivery of
         this Agreement by the Company, nor the consummation by the Company of
         the transactions contemplated hereby, will:

                   (a) conflict with or violate any provision of the charter or 
         By-laws of the Company;

                   (b) require on the part of the Company any filing with, or
         any permit, authorization, consent or approval of, any court,
         arbitrational tribunal, administrative agency or commission or other
         governmental or regulatory authority or agency (a "Governmental
         Entity"), other than any filing, permit, authorization, consent or
         approval which if not obtained or made would not have a Material
         Adverse Effect or materially adversely affect the ability of the
         Parties to consummate the transactions contemplated by this Agreement;

                   (c) conflict with, result in a breach of, constitute (with or
         without due notice or lapse of time or both) a default under, result in
         the acceleration of, create in any party the right to accelerate,
         terminate, modify or cancel, or require any notice, consent or waiver
         under, any contract, lease, sublease, license, sublicense, franchise,
         permit, indenture, agreement or mortgage for borrowed money, instrument
         of indebtedness, Security Interest (as defined below) or other
         arrangement to which the Company is a party or by which the Company is
         bound or to which any of its assets is subject, other than any
         conflict, breach, default, acceleration, termination, modification or
         cancellation which individually or in the aggregate would not have a
         Material Adverse Effect or materially adversely affect the ability of
         the Parties to consummate the transactions contemplated by this
         Agreement;

                   (d) result in the imposition of any Security Interest upon 
         any assets of the Company; or

                   (e) violate any order, writ, injunction, decree, statute,
         rule or regulation applicable to the Company or any of its properties
         or assets.

         For purposes of this Agreement, "Security Interest" means any mortgage,
         pledge, security interest, encumbrance, charge, or other lien (whether
         arising by contract or by operation of law), other than (i) mechanic's,
         materialmen's, and similar liens, (ii) liens arising under worker's
         compensation, unemployment insurance, social security, retirement, and
         similar legislation, and


                                         -10-

<PAGE>   11


         (iii) liens on goods in transit incurred pursuant to documentary
         letters of credit, in each case arising in the ordinary course of
         business consistent with past custom and practice ("Ordinary Course of
         Business") of the Company and not material to the Company.

              2.5 SUBSIDIARIES. The Company does not, directly or indirectly,
         have the power to vote or direct the voting of sufficient securities to
         elect a majority of the directors of any corporation and does not have
         a similar or analogous power with respect to any other type of business
         entity, including without limitation a trust, partnership or limited
         liability company.

              2.6 REGISTRATION STATEMENT AND FINANCIAL STATEMENTS. The Company
         has previously furnished to the Buyer complete and accurate copies, as
         amended or supplemented (including without limitation Amendment No. 1
         dated January 14, 1997), of its Registration Statement on Form S-1 (as
         initially filed with the Securities and Exchange Commission (the "SEC")
         on December 18, 1996) (the "Company Registration Statement"). As of
         January 14, 1997, the Company Registration Statement did not contain
         any untrue statement of a material fact or omit to state a material
         fact required to be stated therein or necessary to make the statements
         therein, in light of the circumstances under which they were made, not
         misleading. The financial statements of the Company included in the
         Company Registration Statement (the "Financial Statements") (i) comply
         as to form in all material respects with applicable accounting
         requirements and the published rules and regulations of the SEC with
         respect thereto, (ii) have been prepared in accordance with United
         States generally accepted accounting principles ("GAAP") applied on a
         consistent basis throughout the periods covered thereby (except as may
         be indicated therein or in the notes thereto), (iii) fairly present the
         financial condition, results of operations and cash flows of the
         Company as of the respective dates thereof and for the periods referred
         to therein, and (iv) are consistent with the books and records of the
         Company.

              2.7 ABSENCE OF CERTAIN CHANGES. Since December 31, 1996, (a) there
         has not been any material adverse change in the assets, business,
         financial condition, results of operations or future prospects (other
         than (i) prospects relating to the economy in general or the
         biotechnology or pharmaceutical industries in general or (ii) any
         circumstances or events arising out of or resulting from the execution
         or performance of this Agreement, including without limitation any
         action by Pfizer, Inc. or Wyeth-Ayerst or any departure of any key
         employees) of the Company, and (b) the Company has not taken (except
         with the prior written consent of the Buyer) any of the actions set
         forth in paragraphs (a) through (n) of Section 4.4, except that the
         Company



                                         -11-


<PAGE>   12



         has incurred costs, expenses and obligations in connection with the
         Company Registration Statement.

              2.8 UNDISCLOSED LIABILITIES. The Company does not have any
         material liability (whether known or unknown, whether absolute or
         contingent, whether liquidated or unliquidated and whether due or to
         become due), except for (a) liabilities shown on its balance sheet
         dated December 31, 1996 included in the Company Registration Statement
         (the "Most Recent Balance Sheet"), (b) liabilities which have arisen
         since December 31, 1996 in the Ordinary Course of Business or in
         connection with the public offering contemplated by the Company
         Registration Statement and (c) liabilities incurred in the Ordinary
         Course of Business which are not required by GAAP to be reflected on a
         balance sheet or in the notes thereto.

              2.9 TAX MATTERS. The Company has filed all tax returns that it was
         required to file and, to the knowledge of the Company, all such tax
         returns were correct and complete in all material respects. The Company
         is not a party to any tax allocation or sharing agreement. The Company
         is not and has not ever been a member of an "affiliated group" of
         corporations (within the meaning of Section 1504 of the Code).

             2.10 Intellectual Property.
                  ---------------------

                  (a) To the knowledge of the Company, the Company owns, or is
         licensed or otherwise possesses legally enforceable rights to use, all
         patents, trademarks, trade names, service marks, copyrights (and any
         applications for such patents, trademarks, trade names, service marks
         and copyrights), schematics, technology, know-how, computer software
         programs or applications and tangible or intangible proprietary
         information or material (collectively, "Intellectual Property") that
         are material to the conduct of its business as currently conducted or
         planned to be conducted (as described in the Company Registration
         Statement). Section 2.10 of the Disclosure Schedule lists (i) all
         material written licenses, sublicenses and other agreements to which
         the Company is a party and pursuant to which any third party is
         authorized to use any Intellectual Property rights of the Company or
         pursuant to which the Company assigns Intellectual Property rights to
         any third party, and (ii) all material written licenses, sublicenses
         and other agreements to which the Company is a party and pursuant to
         which the Company is authorized to use any third party patents,
         trademarks, copyrights (including software) or other Intellectual
         Property.

                  (b) The Company has not been named in any suit, action or
         proceeding which involves a claim of infringement by the Company of any
         Intellectual Property right of any third party, which, if determined
         adversely to the Company, would reasonably



                                         -12-




<PAGE>   13




         foreseeably have a material adverse effect on the assets, business,
         financial condition, results of operations or future prospects of the
         Company, and the Company has not received any written threat as to the
         institution by a third party of any such suit, action or proceeding.
         The Company is a party to agreements that provide that the Company will
         own all Intellectual Property rights in any developments made by any of
         its employees or contractors. To the knowledge of the Company, the
         conduct of its business as currently conducted and planned to be
         conducted (as described in the Company Registration Statement) does not
         infringe any Intellectual Property rights of a third party, other than
         infringements that do not and will not, individually or in the
         aggregate, have a Material Adverse Effect. To the knowledge of the
         Company, the Intellectual Property rights of the Company are not being
         infringed by activities, products or services of any third party in a
         manner that has a Material Adverse Effect.

             2.11 MATERIAL CONTRACTS. Item 16 of the Company Registration
         Statement lists each contract to which the Company is a party which is
         material to the Company (a "Material Contract"). The Company has
         delivered to the Buyer a correct and complete copy of each Material
         Contract. As to each Material Contact, neither the Company nor, to the
         knowledge of the Company, the other party thereto is in breach or
         default thereunder, other than breaches or defaults which do not,
         either individually or in the aggregate, have a Material Adverse
         Effect.

             2.12 LITIGATION. Section 2.12 of the Disclosure Schedule
         identifies, and contains a brief description of, (a) any unsatisfied
         judgement, order, decree, stipulation or injunction and (b) any claim,
         complaint, action, suit, proceeding, hearing or investigation of or
         before any Governmental Entity or before any arbitrator to which the
         Company is a party or, to the knowledge of the Company, is threatened
         to be made a party that reasonably could be expected to have a Material
         Adverse Effect.

             2.13 EMPLOYEES. To the knowledge of the Company, as of the date of
         this Agreement, no key employee of the Company or group of employees of
         the Company has any plans to terminate employment with the Company,
         which terminations, either individually or in the aggregate, have a
         Material Adverse Effect. The Company is not a party to or bound by any
         collective bargaining agreement.

             2.14 Employee Benefits and Contracts.
                  -------------------------------

                  (a) The Disclosure Schedule lists all employee benefit plans
         (as defined in Section 3(3) of the Employee Retirement Income Security
         Act of 1974, as amended ("ERISA")) maintained by the Company. Each of
         such employee benefit plans complies in all material respects with
         applicable requirements of ERISA or the


                                         -13-









<PAGE>   14




         Code, and no "reportable event" or "prohibited transaction" (as such
         terms are defined in ERISA) has occurred with respect to any such plan,
         and no termination, if it has occurred or were to occur before the
         Effective Date, would present a risk of liability to any Governmental
         Entity or other persons that would have a Material Adverse Effect.

                   (b) The Company has never maintained an employee benefit plan
         subject to Section 412 of the Code or Title IV of ERISA. Each employee
         benefit plan of the Company intended to be qualified under Section
         401(a) of the Code has received a favorable determination letter from
         the Internal Revenue Service confirming such qualification. The Company
         has never had an obligation to contribute to a "multiemployer plan" as
         defined in Section 4001(a)(3) of ERISA. There are no unfunded
         obligations under any employee benefit plan of the Company providing
         benefits after termination of employment to any employee or former
         employee, including but not limited to retiree health coverage and
         deferred compensation, but excluding continuation of health coverage
         required to be continued under Section 4980(B) of the Code. Each
         employee benefit plan of the Company may be amended or terminated by
         the Company without the consent or approval of any other person. Except
         for Section 1.10(a) of this Agreement, there is no employee benefit
         plan, stock option plan, stock appreciation right plan, restricted
         stock plan, stock purchase plan, or severance benefit plan of the
         Company, any of the benefits of which will be increased or the vesting
         of the benefits under which will be accelerated by the occurrence of
         any of the transactions contemplated by this Agreement or the benefits
         under which will be calculated on the basis of the transactions
         contemplated by this Agreement.

                   (c) The Company is not obligated to make any parachute
         payment, as defined in Section 280G(b)(2) of the Code, nor will any
         parachute payment be deemed to have occurred as a result of or arising
         out of any of the transactions contemplated by this Agreement. The
         Company has no contract, agreement, obligation or arrangement with any
         employee or other person, any of the benefits of which will be
         increased or the vesting of the benefits under which will be
         accelerated by any change of control of the Company or the occurrence
         of any of the transactions contemplated by this Agreement or the
         benefits under which will be calculated on the basis of the
         transactions contemplated by this Agreement (other than those
         transactions contemplated by Section 1.10(a) hereof).

             2.15  Environmental Matters.
                   ---------------------

                   (a) The Company has complied with all applicable
         Environmental Laws (as defined below), except for violations of
         Environmental Laws that do not and will not, individually or in



                                         -14-









<PAGE>   15










         the aggregate, have a Material Adverse Effect. There is no pending or,
         to the knowledge of the Company, threatened civil or criminal
         litigation, written notice of violation, formal administrative
         proceeding, or investigation, inquiry or information request by any
         Governmental Entity, relating to any Environmental Law involving the
         Company, except for litigation, notices of violations, formal
         administrative proceedings or investigations, inquiries or information
         requests that will not, individually or in the aggregate, have a
         Material Adverse Effect. For purposes of this Agreement, "Environmental
         Law" means any federal, state or local law, statute, rule or regulation
         or the common law relating to the environment or occupational health
         and safety.

                   (b) To the knowledge of the Company, there have been no
         releases of any Materials of Environmental Concern (as defined below)
         into the environment at any parcel of real property or any facility
         formerly or currently owned, operated or controlled by the Company,
         other than releases that do not and will not, individually or in the
         aggregate, have a Material Adverse Effect. For purposes of this
         Agreement, "Materials of Environmental Concern" means any chemicals,
         pollutants or contaminants, hazardous substances (as such term is
         defined under CERCLA), solid wastes and hazardous wastes (as such terms
         are defined under the federal Resources Conservation and Recovery Act),
         toxic materials, oil or petroleum and petroleum products, or any other
         material subject to regulation under any Environmental Law.

                   (c) Set forth in Section 2.15(c) of the Disclosure Schedule
         is a list of all of the solid and hazardous waste transporters and
         treatment, storage and disposal facilities that have been utilized by
         the Company. The Company is not aware of any material environmental
         liability of any such transporter or facility.

             2.16  LEGAL COMPLIANCE. The Company and the conduct and operations
         of its business, are in compliance with each law (including rules and
         regulations thereunder) of any federal, state, local or foreign
         government, or any Governmental Entity, which (a) affects or relates to
         this Agreement or the transactions contemplated hereby or (b) is
         applicable to the Company or its business, except for any violations of
         or defaults under a law referred to in clause (b) above which do not
         and will not, individually or in the aggregate, have a Material Adverse
         Effect.

             2.17  PERMITS. The Company holds all permits, licenses,
         registrations, certificates, orders or approvals from any Governmental
         Entity (including without limitation those issued or required under
         Environmental Laws and those relating to the occupancy or use of owned
         or leased real property) ("Permits")




                                         -15-










<PAGE>   16










         material to the conduct of its business. Each such Permit is in full
         force and effect and, to the knowledge of the Company, will continue in
         full force and effect following the Closing.

             2.18 BROKERS' FEES. The Company does not have any liability or
         obligation to pay any fees or commissions to any broker, finder or
         agent with respect to the transactions contemplated by this Agreement.

             2.19 COMPANY ACTION. The Board of Directors of the Company, at a
         meeting duly called and held, has by the unanimous vote of all
         directors present (i) determined that the Merger is fair and in the
         best interests of the Company and its stockholders, (ii) adopted this
         Agreement in accordance with the provisions of the Delaware General
         Corporation Law, and (iii) directed that this Agreement and the Merger
         be submitted to the Company Stockholders for their adoption and
         approval and resolved to recommend that Company Stockholders vote in
         favor of the adoption of this Agreement and the approval of the Merger.

             2.20 COMPANY STOCKHOLDERS. As of the date of this Agreement, the
         Company has 52 stockholders of record. Based solely upon
         representations made to the Company by such stockholders, 24 of such
         stockholders are "accredited investors" (as defined in Regulation D
         promulgated under the Securities Act ("Regulation D")), and 28 of such
         stockholders are not "accredited investors" under Regulation D.


                                     ARTICLE III

                    REPRESENTATIONS AND WARRANTIES OF THE BUYER
                           AND THE TRANSITORY SUBSIDIARY

              Each of the Buyer and the Transitory Subsidiary represents and
         warrants to the Company as follows:

              3.1 ORGANIZATION. Each of the Buyer and the Transitory Subsidiary
         is a corporation duly organized, validly existing and in good standing
         under the laws of the state of its incorporation. The Buyer has all
         requisite corporate power and authority to carry on the businesses in
         which it is engaged and to own and use the properties owned and used by
         it. The Buyer is not in default under or in violation of any provision
         of its Certificate of Incorporation, as amended, or By-laws.

              3.2 CAPITALIZATION. The authorized capital stock of the Buyer, as
         of January 14, 1997, consists of (i) 100,000,000 shares of Buyer Common
         Stock, of which 23,924,063 shares were issued and outstanding and none
         were held in the treasury of the Buyer and




                                         -16-






<PAGE>   17










         (ii) 5,000,000 of authorized blank check preferred stock, $.01 par
         value per share, none of which have been designated. All of the issued
         and outstanding shares of Buyer Common Stock are duly authorized,
         validly issued, fully paid, nonassessable and free of all preemptive
         rights. All of the Merger Shares will be, when issued in accordance
         with this Agreement, duly authorized, validly issued, fully paid,
         nonassessable and free of all preemptive rights.

              3.3 AUTHORIZATION OF TRANSACTION. Each of the Buyer and the
         Transitory Subsidiary has all requisite power and authority to execute
         and deliver this Agreement and to perform its obligations hereunder.
         The execution and delivery of this Agreement by the Buyer and the
         Transitory Subsidiary and the performance by the Buyer and the
         Transitory Subsidiary of this Agreement and the consummation of the
         transactions contemplated hereby and thereby by the Buyer and the
         Transitory Subsidiary have been duly and validly authorized by all
         necessary corporate action on the part of the Buyer and Transitory
         Subsidiary. This Agreement has been duly and validly executed and
         delivered by the Buyer and the Transitory Subsidiary and constitutes a
         valid and binding obligation of the Buyer and the Transitory
         Subsidiary, enforceable against them in accordance with its terms. No
         vote of the holders of any class or series of Buyer capital stock is
         necessary to approve this Agreement or the Merger, and no such vote
         will be sought by Buyer.

              3.4 NONCONTRAVENTION. Subject to compliance with the applicable
         requirements of the Securities Act and any applicable state securities
         laws, the Securities Exchange Act of 1934, as amended (the "Exchange
         Act") and the filing of the Certificate of Merger as required by the
         Delaware General Corporation Law, neither the execution and delivery of
         this Agreement by the Buyer or the Transitory Subsidiary, nor the
         consummation by the Buyer or the Transitory Subsidiary of the
         transactions contemplated hereby, will (a) conflict or violate any
         provision of the charter or By-laws of the Buyer or the Transitory
         Subsidiary, (b) require on the part of the Buyer or the Transitory
         Subsidiary any filing with, or permit, authorization, consent or
         approval of, any Governmental Entity, other than any filing, permit,
         authorization, consent or approval which if not obtained or made would
         not have a material adverse effect on the assets, business, financial
         condition, results of operations or future prospects (other than
         prospects relating to the economy in general or the biotechnology or
         pharmaceutical industries in general) of the Buyer (a "Buyer Material
         Adverse Effect") or on the ability of the Parties to consummate the
         transactions contemplated by this Agreement, (c) conflict with, result
         in breach of, constitute (with or without due notice or lapse of time
         or both) a default under, result in the acceleration of, create in any
         party any right to






                                         -17-








<PAGE>   18










         accelerate, terminate, modify or cancel, or require any notice, consent
         or waiver under, any contract, lease, sublease, license, sublicense,
         franchise, permit, indenture, agreement or mortgage for borrowed money,
         instrument of indebtedness, Security Interest or other arrangement to
         which the Buyer or Transitory Subsidiary is a party or by which either
         is bound or to which any of their assets are subject, other than any
         conflict, breach, default, acceleration, termination, modification or
         cancellation which individually or in the aggregate would not have a
         Buyer Material Adverse Effect or have a material adverse effect on the
         ability of the Parties to consummate the transactions contemplated by
         this Agreement, or (d) violate any order, writ, injunction, decree,
         statute, rule or regulation applicable to the Buyer or the Transitory
         Subsidiary or any of their properties or assets.

              3.5  Reports and Financial Statements.
                   --------------------------------

                   (a) The Buyer has previously furnished to the Company
         complete and accurate copies, as amended or supplemented, of its (a)
         Prospectus dated May 6, 1996, as filed with the SEC (the "Buyer
         Prospectus"), and (b) all reports filed by the Buyer under Section 13
         of the Exchange Act with the SEC since May 6, 1996 (such reports are
         collectively referred to herein as the "Buyer Reports"). As of their
         respective dates, the Buyer Reports did not contain any untrue
         statement of a material fact or omit to state a material fact required
         to be stated therein or necessary to make the statements therein, in
         light of the circumstances under which they were made, not misleading.
         The audited financial statements and unaudited interim financial
         statements of the Buyer included in the Buyer Reports (i) comply as to
         form in all material respects with applicable accounting requirements
         and the published rules and regulations of the SEC with respect
         thereto, (ii) have been prepared in accordance with GAAP applied on a
         consistent basis throughout the periods covered thereby (except as may
         be indicated therein or in the notes thereto, and in the case of
         quarterly financial statements, as permitted by Form 10-Q under the
         Exchange Act), (iii) fairly present the consolidated financial
         condition, results of operations and cash flows of the Buyer as of the
         respective dates thereof and for the periods referred to therein, and
         (iv) are consistent with the books and records of the Buyer.

                   (b) As to each contract that is material to the Buyer's
         business and which has been filed by the Buyer as an exhibit to any of
         the Buyer Reports, neither the Buyer nor, to the knowledge of the
         Buyer, the other party thereto is in breach or default thereunder,
         other than breaches or defaults which do not, either individually or in
         the aggregate, have a Buyer Material Adverse Effect.





                                         -18-








<PAGE>   19










                  (c) The Buyer has filed in a timely manner all documents that
         the Buyer was required to file under the Exchange Act.

              3.6 ABSENCE OF MATERIAL ADVERSE CHANGES. Since September 30, 1996,
         there has not been any material adverse change in the assets, business,
         financial condition, results of operations or future prospects (other
         than (i) prospects relating to the economy in general or the
         biotechnology or pharmaceutical industries in general or (ii) any
         circumstances or events arising out of or resulting from the execution
         or performance of this Agreement) of the Buyer.

             3.7 BROKERS' FEES. Except as to Robertson, Stephens & Co. LLP,
         neither the Buyer nor the Transitory Subsidiary has any liability or
         obligation to pay any fees or commissions to any broker, finder or
         agent with respect to the transactions contemplated by this Agreement.

              3.8 BUYER COMMON STOCK. At the Effective Time, the Merger Shares
         and shares of Buyer Common Stock issuable upon exercise of the Options
         will not be subject to preemptive rights and will not be subject to any
         restriction on transfer imposed by the Buyer, except (i) restrictions
         on resale of the Merger Shares under the Securities Act and applicable
         state securities laws (because the Merger Shares will not have been
         registered thereunder); (ii) as provided in agreements of certain of
         the Company Stockholders referred to in Section 4.8 of this Agreement
         not to sell, transfer or convey such shares for a specified period of
         time after the Closing Date; and (iii) with respect to the Merger
         Shares issued to PerSeptive BioSystems, Inc. ("PBIO"), the repurchase
         option described in Section 5 of the Consulting and Services Agreement
         dated June 28, 1996 by and between the Company and PBIO, as amended
         from time to time.

              3.9 LITIGATION. The Buyer is not a party to or threatened to be
         made a party to (a) any unsatisfied judgment, order, decree,
         stipulation or injunction or (b) any claim, complaint, action, suit,
         proceeding, hearing or investigation of or before any Governmental
         Entity or before any arbitrator to which the Buyer is a party or, to
         the knowledge of the Buyer, is threatened to be made a party that
         reasonably could be expected to have a Buyer Material Adverse Effect.





                                         -19-



<PAGE>   20




                                     ARTICLE IV

                                     COVENANTS

              4.1 BEST EFFORTS. Each of the Parties shall use its best efforts,
         to the extent commercially reasonable, to take all actions and to do
         all things necessary, proper or advisable to consummate the
         transactions contemplated by this Agreement (including without
         limitation making the representations referenced in Section 5.2(h) and
         Section 5.3(f)); provided, however, that notwithstanding anything in
         this Agreement to the contrary, the Buyer shall not be required to sell
         or dispose of or hold separately (through a trust or otherwise) any of
         its assets or businesses.

              4.2 NOTICES AND CONSENTS. The Company shall use its best efforts
         to obtain, at its expense, all such waivers, permits, consents,
         approvals or other authorizations from third parties and Governmental
         Entities, and to effect all such registrations, filings and notices
         with or to third parties and Governmental Entities, as may be required
         by or with respect to the Company in connection with the transactions
         contemplated by this Agreement (including without limitation those
         listed in Section 2.4 of the Disclosure Schedule).

              4.3 Confidential Offering Memorandum and Information Statement.
                  ----------------------------------------------------------

                  (a) As promptly as reasonably practicable following the
         execution of this Agreement, the Buyer and the Company shall jointly
         prepare appropriate materials for the purpose of making disclosure of
         the Merger to and soliciting the written consents of Company
         Stockholders in favor of the adoption of this Agreement and approval of
         the Merger. Such materials shall be in the form of a joint confidential
         offering memorandum and information statement (the "Offering
         Memorandum/Information Statement") which shall contain the information
         concerning the Buyer, the Transitory Subsidiary and the Company
         required under Regulation D (including without limitation, Rule
         502(b)(2) thereof) and a form of written consent soliciting written
         consents from Company Stockholders in favor of the approval of the
         Merger and adoption of this Agreement.

                  (b) Promptly following preparation of the Offering
         Memorandum/Information Statement, the Company will circulate to each
         Company Stockholder the Offering Memorandum/Information Statement
         (which may include by reference, Buyer's Reports and other materials
         filed by the Buyer under the Exchange Act previously sent to Company
         Stockholders) and, pursuant thereto and in accordance with the Delaware
         General Corporation Law, shall




                                         -20-


<PAGE>   21


         solicit written consents from Company Stockholders in favor of the
         adoption of this Agreement and the approval of the Merger along with
         such other instruments and documents (including, without limitation,
         investor questionnaires and investment representations) as shall be
         required for the offering and sale of Merger Shares to be exempt from
         the registration requirements of the Securities Act pursuant to Rule
         506 of Regulation D.

                   (c) The Company shall comply with all applicable provisions
         of and rules under the Securities Act and the Delaware General
         Corporation Law in the preparation and distribution of the Offering
         Memorandum/Information Statement and the solicitation of written
         consents thereunder. Without limiting the foregoing, the Company shall
         ensure that the information in the Offering Memorandum/Information
         Statement relating to the Company or furnished by the Company in
         writing for inclusion therein does not, as of the date on which it is
         distributed to Company Stockholders, and as of the date of taking of
         action by written consent, contain any untrue statement of a material
         fact or omit to state a material fact necessary in order to make the
         statements made, in light of the circumstances under which they were
         made, not misleading (provided that the Company shall not be
         responsible for the accuracy or completeness of any information
         relating to the Buyer or any other information furnished by the Buyer
         in writing for inclusion therein).

                   (d) The Buyer shall comply with all applicable provisions of
         and rules under the Securities Act in the preparation and distribution
         of the Offering Memorandum/ Information Statement and the offering and
         issuance of the Merger Shares. Without limiting the foregoing, the
         Buyer shall ensure that the Offering Memorandum/Information Statement
         does not, as of the date on which it is distributed to Company
         Stockholders, and as of the date of the taking of action by written
         consent, contain any untrue statement of a material fact or omit to
         state a material fact necessary in order to make the statements made,
         in light of the circumstances under which they were made, not
         misleading (provided that the Buyer shall not be responsible for the
         accuracy or completeness of any information relating to the Company or
         any other information furnished by the Company in writing for inclusion
         therein).

                   (e) The Company, acting through its Board of Directors, shall
         include in the Offering Memorandum/Information Statement the
         recommendation of its Board of Directors that the Company Stockholders
         consent to the adoption of this Agreement and the approval of the
         Merger, and shall otherwise use its best efforts to obtain the
         Requisite Stockholder Approval. Notwithstanding the foregoing, the
         obligations set forth in this paragraph (e) shall not apply (and the
         Board of Directors shall be permitted to modify



                                         -21-











<PAGE>   22










         or withdraw any such recommendation previously made) if (i) the Company
         receives a bona fide written offer, subject only to customary
         conditions (excluding any financing condition), for an acquisition of
         all or substantially all of the Company on terms more favorable in the
         aggregate, from a financial point of view, to Company Stockholders than
         the terms of the Merger (a "Higher Offer") and (ii) the Board of
         Directors of the Company is advised in a written opinion from outside
         legal counsel (a copy of which is furnished to the Buyer) that the
         fiduciary duties of the Board of Directors under applicable law
         prohibit it from fulfilling the foregoing obligations.

              4.4  OPERATION OF BUSINESS. Except as contemplated by this
         Agreement, during the period from the date of this Agreement to the
         Effective Time, the Company shall conduct its operations in the
         Ordinary Course of Business and in compliance in all material respects
         with applicable laws and regulations and, to the extent consistent
         therewith, use reasonable efforts to preserve intact its current
         business organization, keep its physical assets in good working
         condition, keep available the services of its current officers and
         employees and preserve its relationships with customers, suppliers and
         others having business dealings with it to the end that its goodwill
         and ongoing business shall not be impaired in any material respect.
         Without limiting the generality of the foregoing, prior to the
         Effective Time, the Company shall not, without the written consent of
         the Buyer:

                   (a) issue, sell, deliver or agree or commit to issue, sell or
         deliver (whether through the issuance or granting of options, warrants,
         commitments, subscriptions, rights to purchase or otherwise) or
         authorize the issuance, sale or delivery of, except as set forth in
         Section 1.10(d) hereto, or redeem or repurchase, any stock of any class
         or any other securities or any rights, warrants or options to acquire
         any such stock or other securities (except pursuant to the conversion
         or exercise of convertible securities or Options outstanding on the
         date hereof), except as set forth in Section 1.10(d) hereto, or amend
         any of the terms of any convertible securities, Options or Warrants;

                   (b) split, combine or reclassify any shares of its capital
         stock; declare, set aside or pay any dividend or other distribution
         (whether in cash, stock or property or any combination thereof) in
         respect of its capital stock;

                   (c) create, incur or assume any debt not currently
         outstanding (including obligations in respect of capital leases);
         assume, guarantee, endorse or otherwise become liable or responsible
         (whether directly, contingently or otherwise) for the obligations of
         any other person or entity; or make any loans,




                                         -22-








<PAGE>   23










         advances or capital contributions to, or investments in, any other
         person or entity;

                   (d) except for the executive bonuses, not to exceed in the
         aggregate $300,000, enter into, adopt or amend any employee benefit
         plan or any employment or severance agreement or arrangement of the
         type described in Section 2.14 or (except for normal increases in the
         Ordinary Course of Business) increase in any manner the compensation or
         fringe benefits of, or materially modify the employment terms of, its
         directors, officers or employees, generally or individually, or pay any
         benefit not required by the terms in effect on the date hereof of any
         existing employee benefit plan;

                   (e) acquire, sell, lease, encumber or dispose of any assets
         or property, other than purchases and sale of assets in the Ordinary
         Course of Business;

                   (f)  amend its charter or By-laws;

                   (g) change in any material respect its accounting methods,
         principles or practices, except insofar as may be required by a
         generally applicable change in GAAP;

                   (h) discharge or satisfy any Security Interest or pay any
         obligation or liability (including without limitation any payment,
         other than accounting expenses, printing expenses and legal fees,
         relating to the offering that is the subject of the Company
         Registration Statement) other than in the Ordinary Course of Business;

                   (i) mortgage or pledge any of its property or assets or
         subject any such assets to any Security Interest;

                   (j) sell, assign, transfer or license any Intellectual
         Property;

                   (k) enter into, amend (in a manner that is adverse to the
         Company or the Buyer), terminate, take or omit to take any action that
         would constitute a material violation of or material default under, or
         waive any rights under, any Material Contract;

                   (l) make or commit to make any capital expenditure in excess
         of $50,000 per item;

                   (m) take any action or fail to take any action permitted by
         this Agreement with the knowledge that such action or failure to take
         action would result in (i) any of the representations and warranties of
         the Company set forth in this



                                         -23-









<PAGE>   24










         Agreement becoming untrue or (ii) any of the conditions to the Merger
         set forth in Article V not being satisfied; or

                   (n) except as set forth in Section 1.10(d) hereto, agree in
         writing or otherwise to take any of the foregoing actions.

              4.5  FULL ACCESS; INTERIM FINANCIAL STATEMENTS. The Company shall
         permit representatives of the Buyer to have full access (at all
         reasonable times, and in a manner so as not to interfere with the
         normal business operations of the Company) to all premises, properties,
         financial and accounting records, contracts, other records and
         documents, and personnel, of or pertaining to the Company. Promptly
         following the end of each month between the date of this Agreement and
         the Closing Date, the Company shall prepare and furnish to the Buyer
         financial statements of the Company as of and for the month and year to
         date period ending on the last day of such month, all in a manner
         consistent with the Company's past practice.

              4.6  NOTICE OF BREACHES. The Company shall promptly deliver to the
         Buyer written notice of any event or development that would (a) render
         any statement, representation or warranty of the Company in this
         Agreement (including the Disclosure Schedule) inaccurate or incomplete
         in any material respect, or (b) constitute or result in a breach by the
         Company of, or a failure by the Company to comply with, any agreement
         or covenant in this Agreement applicable to such party. The Buyer or
         the Transitory Subsidiary shall promptly deliver to the Company written
         notice of any event or development that would (i) render any statement,
         representation or warranty of the Buyer or the Transitory Subsidiary in
         this Agreement inaccurate or incomplete in any material respect, or
         (ii) constitute or result in a breach by the Buyer or the Transitory
         Subsidiary of, or a failure by the Buyer or the Transitory Subsidiary
         to comply with, any agreement or covenant in this Agreement applicable
         to such party. No such disclosure shall be deemed to avoid or cure any
         such misrepresentation or breach.

              4.7  EXCLUSIVITY. The Company shall not, and the Company shall use
         its best efforts to cause its Affiliates and each of its officers,
         directors, employees, representatives and agents not to, directly or
         indirectly, (a) encourage, solicit, initiate, engage or participate in
         discussions or negotiations with any person or entity (other than the
         Buyer) concerning any merger, consolidation, sale of material assets,
         tender offer, recapitalization, accumulation of Company Shares, proxy
         solicitation or other business combination involving the Company, any
         subsidiary or any division of the Company or any subsidiary (an
         "Acquisition Transaction") or (b) provide any non-public





                                         -24-








<PAGE>   25










         information concerning the business, properties or assets of the
         Company or any subsidiary to any person or entity (other than the
         Buyer). Notwithstanding the foregoing, the Company may furnish or cause
         to be furnished non-public information concerning the business,
         properties or assets of the Company to any other person or entity, and
         may engage in discussions or negotiations with another person or
         entity, if in either case (i) such person or entity has submitted a
         Higher Offer to the Company prior to the receipt of Requisite
         Stockholder Approval and (ii) the Board of Directors of the Company is
         advised in a written opinion from outside legal counsel (a copy of
         which is furnished to the Buyer) that the fiduciary duties of the Board
         of Directors under applicable law so require. The Company shall
         immediately notify the Buyer of, and shall disclose to the Buyer all
         details of, any inquiries, discussions or negotiations of the nature
         described in the first sentence of this Section 4.7.

              4.8  AGREEMENTS FROM CERTAIN COMPANY STOCKHOLDERS. In order to
         induce the Buyer and the Transitory Subsidiary to enter into this
         Agreement, the Company Stockholders listed on Schedule 4.8 hereto have
         each entered into a Stockholder Agreement by and among such
         Stockholder, the Company and the Buyer in the form of Exhibit A. The
         Company agrees to use its best efforts to assure that all such
         Stockholder Agreements remain in full force and effect through and
         including the Effective Time.

             4.9  LISTING OF MERGER SHARES. The Buyer shall use its best efforts
         to list the Merger Shares on the Nasdaq National Market at the time
         that the Registration Statement (as defined in Section 4.1(b)) is
         declared effective by the SEC.

             4.10 INDEMNIFICATION. The Buyer shall not, for a period of six
         years after the Effective Time, take any action to alter to impair any
         exculpatory or indemnification provisions now existing in the Amended
         and Restated Certificate of Incorporation or By-Laws of the Company for
         the benefit of any individual who served as a director or officer of
         the Company at any time prior to the Effective Time, except for any
         changes which may be required to conform with changes in applicable law
         and any changes which do not affect the application of such provisions
         to acts or omissions of such individuals prior to the Effective Time.

             4.11 Registration of Buyer Common Stock Comprising the Merger 
                  -------------------------------------------------------
                  Shares.
                  ------

                  (a) For purposes of this Agreement, "Registrable Shares"
         shall mean the shares of Buyer Common Stock issued in the Merger (and
         any shares received in respect of such shares because of a stock split,
         stock dividend, recapitalization, classification or other live event),
         but excluding shares of Buyer Common Stock



                                         -25-








<PAGE>   26


         issued in the Merger that have been sold or otherwise transferred by
         the Company Stockholders who initially received such shares in the
         Merger (collectively, the "Holders"); provided however, that a
         distribution of shares of Buyer Common Stock issued in the Merger
         without additional consideration, to underlying beneficial owners (such
         as the general and limited partners, shareholders or trust
         beneficiaries of a Holder) shall not be deemed such a sale or transfer
         for purposes of this Section 4.11 and such underlying beneficial owners
         shall be entitled to the same rights under this Section 4.11 as the
         initial Holder from which the Registrable Shares were received and
         shall be deemed a Holder for the purposes of this Section 4.11.

                   (b) On or before June 2, 1997, the Buyer shall file, and
         shall use its best efforts to have declared effective as promptly as
         practicable thereafter, a "shelf" registration statement (the
         "Registration Statement") on Form S-3 (or such successor or other
         appropriate form) pursuant to Rule 415 (or similar rule that may be
         adopted by the SEC under the Securities Act) for the resale of the
         Registrable Shares; provided, that in the event that the Buyer is not
         eligible to utilize a Form S-3 registration statement, Buyer's
         obligations under this sentence shall instead require the filing of a
         Registration Statement on Form S-1 or Form S-2, it being understood by
         the parties that at such time as the Buyer becomes eligible to use Form
         S-3 it shall be entitled to convert any registration statement on Form
         S-1 or S-2 to a registration statement on Form S-3. Except as set forth
         below, the Buyer agrees to use its best efforts to keep the
         Registration Statement effective for a period of three years (or such
         shorter period of time to which the three-year period specified in Rule
         144(k) may be shortened at any time after the date of this Agreement)
         after the Effective Time or, if shorter, when (i) all the Registrable
         Shares have been sold pursuant to the Registration Statement or (ii)
         the first date on which each Holder may sell all of the Registrable
         Shares held by such Holder without registration pursuant to Rule 144 of
         the SEC within a three-month period.

                   (c) The Buyer shall use its best efforts to qualify all
         Registrable Shares under any applicable state securities laws;
         PROVIDED, HOWEVER, that Buyer shall not be required to qualify as a
         foreign corporation or execute a general consent to service of process
         in any jurisdiction.

                   (d) From time to time, the Buyer will amend or supplement the
         Registration Statement and any prospectus contained therein to the
         extent necessary to comply with the Securities Act and any applicable
         state securities statute or regulations. The Buyer will also promptly
         provide the Holders with as many copies



                                         -26-










<PAGE>   27





         of the prospectus contained in the Registration Statement as Holders
         may reasonably request.

                   (e) The Buyer shall be entitled to (i) postpone the filing or
         effectiveness of the Registration Statement or (ii) if effective, elect
         that the Registration Statement not be usable and require each Holder
         seeking to sell Registrable Shares pursuant to the Registration
         Statement to suspend sales or purchases pursuant to any prospectus
         contained therein, for a reasonable period of time, but not in excess
         of 60 days (a "Blackout Period"), if the Buyer determines in good faith
         that the registration and distribution of Registrable Shares (or the
         use of the Registration Statement or any related prospectus) would
         interfere with any pending material acquisition, material corporate
         reorganization or any other material corporate development involving
         the Buyer or any of its subsidiaries or would require premature
         disclosure thereof. If circumstances beyond the control of the Buyer
         require a Black-Out Period, the Buyer agrees to use its best efforts to
         (i) cause such filings to be made or the registration statement to be
         declared effective and/or to (ii) lift such suspension as soon as
         possible after the commencement of a Black-Out Period. The Buyer shall
         promptly give each Holder seeking to sell or purchase Registrable
         Shares pursuant to the Registration Statement written notice of such
         determination and an approximation of the anticipated delay; PROVIDED,
         HOWEVER, that the aggregate number of days included in all Blackout
         Periods during any consecutive 12 months shall not exceed 120 days.

                   (f) Each Holder seeking to sell Registrable Shares pursuant
         to the Registration Statement shall provide in writing all information
         reasonably requested by the Buyer for inclusion in or in connection
         with the Registration Statement and any such information shall not
         contain any untrue statement of a material fact or omit to state a
         material fact required to be stated therein or necessary in order to
         make the statements therein, in light of the circumstances under which
         they were made, not misleading.

                   (g) The Buyer will indemnify and hold harmless each holder of
         Registrable Shares (including any broker or dealer through whom such
         shares may be sold) and each person, if any, who controls such holder
         or any such broker or dealer within the meaning of Section 15 of the
         Securities Act from and against any and all losses, claims, damages,
         expenses or liabilities, joint or several, to which they or any of them
         become subject under the Securities Act, applicable state securities
         laws or under any other statute or at common law or otherwise, as
         incurred, and, except as hereinafter provided, will reimburse each such
         holder and each such controlling person, if any, for any legal or other
         expenses reasonably incurred by them or any of them in connection



                                         -27-










<PAGE>   28










         with investigating or defending any actions whether or not resulting in
         any liability insofar as such losses, claims, damages, expenses,
         liabilities or actions arise out of or are based upon any untrue
         statement or alleged untrue statement of a material fact contained in
         the Registration Statement, in any preliminary or amended preliminary
         prospectus or in the final prospectus (or the Registration Statement or
         any such prospectus as from time to time amended or supplemented by the
         Buyer), or arise out of or are based upon the omission or alleged
         omission to state therein a material fact required to be stated therein
         or necessary in order to make the statements therein, in the light of
         the circumstances in which they were made, not misleading, or any
         violation by the Buyer of any rule or regulations promulgated under the
         Securities Act or any state securities laws applicable to the Buyer and
         relating to action or inaction required of the Buyer in connection with
         such registration. Notwithstanding the foregoing, the Buyer shall have
         no obligation to indemnify any such holder or controlling person if:
         (i) such untrue statement or omission was made in such Registration
         Statement, preliminary or amended preliminary prospectus or final
         prospectus in reliance upon and in conformity with information
         furnished in writing to the Buyer in connection therewith by such
         holder of Registrable Shares (in the case of indemnification of such
         holder) or such controlling person (in the case of indemnification of
         such controlling person) expressly for use therein, or (ii) such untrue
         statement or alleged untrue statement or omission or alleged omission
         was contained in a preliminary prospectus and corrected in a final or
         amended prospectus copies of which were delivered to such holder of
         Registrable Shares on a timely basis, and such holder of Registrable
         Shares failed to deliver a copy of the final or amended prospectus at
         or prior to the confirmation of the sale of the Registrable Shares to
         the person asserting any such loss, claim, damage or liability in any
         case where such delivery is required by the Securities Act.

                   (h) Each holder of the Registrable Shares so registered will
         indemnify and hold harmless the Buyer, each of its directors, each of
         its officers who have signed or otherwise participated in the
         preparation of the Registration Statement and each person, if any, who
         controls the Buyer within the meaning of Section 15 of the Securities
         Act from and against any and all losses, claims, damages, expenses or
         liabilities, joint or several, to which they or any of them may become
         subject under the Securities Act, applicable state securities law or
         under any other statute or at common law or otherwise, and, except as
         hereinafter provided, will reimburse the Buyer and each such director,
         officer, or controlling person for any legal or other expenses
         reasonably incurred by them or any of them in connection with
         investigating or defending any actions whether or not resulting in any
         liability, insofar as such losses, claims, damages, expenses,





                                         -28-









<PAGE>   29










         liabilities or actions arise out of or are based upon any untrue
         statement of a material fact contained in the Registration Statement,
         in any preliminary or amended preliminary prospectus or in the final
         prospectus (or in the Registration Statement or any such prospectus as
         from time to time amended or supplemented) or arise out of or are based
         upon the omission to state therein a material fact required to be
         stated therein or necessary in order to make the statements therein not
         misleading, but only to the extent that such statement or omission was
         made in reliance upon and in conformity with information furnished in
         writing to the Buyer in connection therewith by such holder of
         Registrable Shares expressly for use therein. Each Holder's obligations
         hereunder shall be limited to an amount equal to the proceeds received
         by such Holder sold in any such registration.

                   (i) Each person entitled to indemnification under this
         Section 4.11 (an "Indemnitee") shall give notice to the party required
         to provide indemnification (the "Indemnitor") promptly after such
         Indemnitee has actual knowledge of any claim as to which indemnity may
         be sought, and the Indemnitor shall assume the defense of any such
         claim and any litigation resulting therefrom, including the employment
         of counsel selected by the Indemnitor (and reasonably acceptable to the
         Indemnitee) and shall assume the payment of all expenses. The
         Indemnitee shall have the right to employ separate counsel in any such
         action and to participate in the defense thereof, but the fees and
         expenses of such counsel shall be at the expense of such Indemnitee,
         except that the Indemnitor shall pay the fees and expenses of such
         counsel if dual representation would be inadvisable due to actual or
         potential differing interests between the parties. The failure of any
         Indemnitee to give notice as provided herein shall not relieve the
         Indemnitor of its obligations under this Section 4.11 except to the
         extent the Indemnitor is materially prejudiced thereby. The Indemnitor
         shall not be liable for any settlement of any such action or
         proceedings effected without its written consent, but if settled with
         its written consent, or if there be a final judgment for the plaintiff
         in any such action or proceeding, the Indemnitor shall indemnify and
         hold harmless such Indemnitee from and against any loss or liability
         (to the extent stated above) by reason of such settlement or judgment.
         Each Indemnitee shall furnish such information regarding itself or the
         claim in question as an Indemnitor may reasonably request in writing
         and as shall be reasonably required in connection with the defense of
         such claim and litigation resulting therefrom.

                   (j) In order to provide for just and equitable contribution
         to joint liability under the Securities Act in any case in which the
         Buyer or any Holder makes a claim for indemnification pursuant to this
         Section 4.11 but it is judicially determined (by the entry of a final
         judgment or decree by a court




                                         -29








<PAGE>   30










         of competent jurisdiction and the expiration of time to appeal or the
         denial of the last right of appeal) that such indemnification may not
         be enforced in such case notwithstanding that this Section 4.11
         provides for indemnification, in such case, then the Buyer and such
         Holder will contribute to the aggregate losses, claims, damages or
         liabilities to which they may be subject (after contribution from
         others) in such proportion as is appropriate to reflect the relative
         fault of the Buyer on the one hand and of the Holder on the other in
         connection with the statements or omission which resulted in such
         losses, claims, damages or liabilities, as well as any other relevant
         equitable considerations or, if the allocation provided herein is not
         permitted by applicable law, in such proportion as shall be appropriate
         to reflect the relative benefits received by the Buyer and any Holder
         from the offering of the securities covered by such Registration
         Statement. The relative fault of the Buyer on the one hand and of the
         Holder on the other shall be determined by reference to, among other
         things, whether the untrue or alleged untrue statement of a material
         fact or omission or alleged omission to state a material fact relates
         to information supplied by the Buyer on the one hand or by the Holder
         on the other, and each party's relative intent, knowledge, access to
         information and opportunity to correct or prevent such statement or
         omission; PROVIDED, HOWEVER, that, in any such case (i) no Holder will
         be required to contribute any amount in excess of the proceeds received
         by such Holder from the sale of Registrable Shares offered by it
         pursuant to the Registration Statement; and (ii) no person or entity
         guilty of fraudulent misrepresentation within the meaning of Section
         11(f) of the Securities Act will be entitled to contribution from any
         person or entity who was not guilty of such fraudulent
         misrepresentation.

                   (k) The Buyer shall bear all costs and expenses of the
         registration provided for in this Section 4.11, including, but not
         limited to, printing, legal and accounting expenses, SEC and NASD
         filing fees and all related "Blue Sky" fees and expenses, and the
         reasonable fees and expenses of one counsel for all Holders PROVIDED,
         HOWEVER, that the Buyer shall have no obligation to pay or otherwise
         bear any portion of the underwriters' or other commissions or discounts
         or brokerage fees or commissions, attributable to the Registrable
         Shares being offered and sold by the Holders.

                   (l) So long as the Registration Statement is effective
         covering the resale of the Registrable Shares, the Buyer shall file in
         a timely manner all documents that the Buyer is required to file under
         the Exchange Act and shall furnish to each Holder upon request:

                       (i)   any such documents filed by the Buyer with the SEC;




                                         -30-








<PAGE>   31




                       (ii)  upon the reasonable request of the Holder, any
                             other information concerning the Buyer that is
                             generally available to the public; and

                       (iii) an adequate number of copies of the prospectuses
                             relating to the resale of the Registrable Shares to
                             supply to any party requiring such prospectuses.


                                      ARTICLE V

                        CONDITIONS TO CONSUMMATION OF MERGER

             5.1   CONDITIONS TO EACH PARTY'S OBLIGATIONS.  The respective
         obligations of each Party to consummate the Merger are subject to the
         satisfaction of the following conditions:

                   (a) this Agreement and the Merger shall have received the
         Requisite Stockholder Approval;

                   (b) no action, suit or proceeding shall be pending or
         threatened by or before any Governmental Entity wherein an unfavorable
         judgment, order, decree, stipulation or injunction would (i) prevent
         consummation of any of the transactions contemplated by this Agreement,
         (ii) cause any of the transactions contemplated by this Agreement to be
         rescinded following consummation or (iii) affect adversely the right of
         the Buyer to own, operate or control any of the assets and operations
         of the Surviving Corporation following the Merger, and no such
         judgment, order, decree, stipulation or injunction shall be in effect;
         and

                   (c) The Buyer shall have received an opinion from Hale and
         Dorr LLP to the effect that the offering and sale of the Merger Shares
         is exempt from the registration requirements of the Securities Act.

             5.2   CONDITIONS TO OBLIGATIONS OF THE BUYER AND THE TRANSITORY
         SUBSIDIARY. The obligation of each of the Buyer and the Transitory
         Subsidiary to consummate the Merger is subject to the satisfaction of
         the following additional conditions:

                   (a) the holders of at least 95% of the total number of
         outstanding Company Shares as of the Effective Time shall have
         consented in writing to the adoption of this Agreement and the approval
         of the Merger;


                                         -31-





<PAGE>   32





                   (b) the Company shall have obtained all of the waivers,
         permits, consents, approvals or other authorizations, and effected all
         of the registrations, filings and notices, referred to in Section 4.2,
         except for any which if not obtained or effected would not have a
         material adverse effect on the assets, business, financial condition,
         results of operations or future prospects of the Company or on the
         ability of the Parties to consummate the transactions contemplated by
         this Agreement;

                   (c) the representations and warranties of the Company set
         forth in Article II shall have been true and correct when made on the
         date hereof and shall be true and correct in all material respects
         (other than those representations and warranties which are qualified as
         to materiality, which shall be true and correct in accordance with
         their terms) as of the Effective Time as if made as of the Effective
         Time, except for representations and warranties made as of a specific
         date, which shall be true and correct as of such date;

                   (d) the Company shall have performed or complied with in all
         material respects its agreements and covenants required to be performed
         or complied with under this Agreement as of or prior to the Effective
         Time (other than those agreements and covenants which are qualified as
         to materiality, which shall have been performed or complied with in
         accordance with their terms);

                   (e) the Company shall have delivered to the Buyer and the
         Transitory Subsidiary a certificate (without qualification as to
         knowledge or materiality or otherwise) to the effect that each of the
         conditions specified in clauses (a) and (b) of Section 5.1 and clauses
         (a) through (d) of this Section 5.2 is satisfied in all respects;

                   (f) the Buyer and the Transitory Subsidiary shall have
         received from counsel to the Company an opinion with respect to the
         matters set forth in EXHIBIT B attached hereto, addressed to the Buyer
         and the Transitory Subsidiary and dated as of the Closing Date;

                   (g) the Buyer and the Transitory Subsidiary shall have
         received the resignations, effective as of the Effective Time, of each
         director and officer of the Company specified by the Buyer in writing
         at least one business day prior to the Closing;

                   (h) the Buyer shall have received an opinion from Hale and
         Dorr LLP, in a form reasonably satisfactory to the Buyer, dated the
         Closing Date, based upon certain factual representations of the Company
         and the Buyer reasonably requested by such counsel,



                                         -32-









<PAGE>   33










         to the effect that the Merger will constitute a reorganization for
         federal income tax purposes within the meaning of Section 368(a) of the
         Code and no gain or loss will be recognized by the Company, the Buyer
         or the Transitory Subsidiary as a result of the Merger;

                   (i) the following agreements shall have been executed and
         delivered and shall remain in full force and effect as of the Effective
         Time: (i) the Letter Agreement dated January 18, 1997 by and between
         Comdisco Inc. and the Company; (ii) the Letter Agreement dated January
         18, 1997 by and among Comdisco, Inc., the Company and the Buyer; (iii)
         the Amendment, Consent and Waiver Agreement dated January 18, 1997 by
         and among Wyeth-Ayerst, the Company and the Buyer; (iv) the Letter
         Agreement dated January 18, 1997 by and between Pfizer, Inc. and the
         Company; (v) the Letter Agreement dated January 18, 1997 by and between
         PBIO, the Company and the Buyer; and (vi) the Stockholder Agreements
         with the holders of Company Shares set forth on Schedule 4.8;

                   (j) all actions to be taken by the Company in connection with
         the consummation of the transactions contemplated hereby and all
         certificates, opinions, instruments and other documents required to
         effect the transactions contemplated hereby shall be reasonably
         satisfactory in form and substance to the Buyer and the Transitory
         Subsidiary; and

                   (k) the holders of (i) Options covering at least 90% of the
         Company Shares subject to outstanding Options, and (ii) at least 90% of
         the total number of outstanding Company Shares as of the Effective Time
         held by employees, former employees and consultants of the Company,
         shall have signed a Lock-up Agreement by the Closing Date which shall
         have substantially identical terms to the lock-up provisions set forth
         in the Stockholders Agreement attached hereto as EXHIBIT A.
                                                          
              5.3  CONDITIONS TO OBLIGATIONS OF THE COMPANY. The obligation of
         the Company to consummate the Merger is subject to the satisfaction of
         the following additional conditions:

                   (a) the representations and warranties of the Buyer and the
         Transitory Subsidiary set forth in Article III shall have been true and
         correct when made on the date hereof and shall be true and correct in
         all material respects (other than those representations and warranties
         which are qualified as to materiality, which shall be true and correct
         in accordance with their terms) as of the Effective Time as if made as
         of the Effective Time, except for representations and warranties made
         as of a specific date, which shall be true and correct as of such date;




                                         -33-









<PAGE>   34










                   (b) each of the Buyer and the Transitory Subsidiary shall
         have performed or complied with in all material respects its agreements
         and covenants required to be performed or complied with under this
         Agreement as of or prior to the Effective Time (other than those
         agreements and covenants which are qualified as to materiality, which
         shall have been performed or complied with in accordance with their
         terms);

                   (c) each of the Buyer and the Transitory Subsidiary shall
         have delivered to the Company a certificate (without qualification as
         to knowledge or materiality or otherwise) to the effect that each of
         the conditions specified in clauses (b) and (c) of Section 5.1 and
         clauses (a) and (b) of this Section 5.3 is satisfied in all respects;

                   (d) the Company shall have obtained all of the waivers,
         permits, consents, approvals or other authorizations referred to in
         Section 4.2, except for any waivers, permits, consents, approvals or
         authorizations in whose absence the Merger could be consummated without
         materially adversely affecting the Company or the Company Stockholders;

                   (e) the Company shall have received from counsel to the Buyer
         and the Transitory Subsidiary an opinion with respect to the matters
         set forth in EXHIBIT C attached hereto, addressed to the Company and
         dated as of the Closing Date;

                   (f) the Company shall have received an opinion from Mintz,
         Levin, Cohen, Ferris, Glovsky and Popeo, P.C., addressed to the Company
         Stockholders in a form reasonably satisfactory to the Company, dated
         the Closing Date, based upon certain factual representations of the
         Company and the Buyer reasonably requested by such counsel, to the
         effect that the Merger will constitute a reorganization for federal
         income tax purposes within the meaning of Section 368(a) of the Code
         and no Company Stockholder who received Merger Shares in exchange for
         Company Shares in the Merger shall recognize taxable gain or loss upon
         such exchange; and

                   (g) all actions to be taken by the Buyer and the Transitory
         Subsidiary in connection with the consummation of the transactions
         contemplated hereby and all certificates, opinions, instruments and
         other documents required to effect the transactions contemplated hereby
         shall be reasonably satisfactory in form and substance to the Company.




                                         -34-












<PAGE>   35





                                     ARTICLE VI

                                    TERMINATION

              6.1  TERMINATION OF AGREEMENT. The Parties may terminate this
         Agreement prior to the Effective Time (whether before or after
         Requisite Stockholder Approval) as provided below:

                   (a) the Parties may terminate this Agreement by mutual 
         written consent;

                   (b) the Buyer may terminate this Agreement by giving written
         notice to the Company in the event the Company is in breach, and the
         Company may terminate this Agreement by giving written notice to the
         Buyer and the Transitory Subsidiary in the event the Buyer or the
         Transitory Subsidiary is in breach, of any material representation,
         warranty or covenant contained in this Agreement, and such breach is
         not remedied within 10 days of delivery of written notice thereof;

                   (c) any Party may terminate this Agreement by giving written
         notice to the other Parties at any time after 45 days after the mailing
         of the Offering Memorandum/Information Statement to Company
         Stockholders pursuant to Section 4.3 hereof if prior to such date the
         Company does not have the consents providing for the Requisite
         Stockholder Approval;

                   (d) the Buyer may terminate this Agreement by giving written
         notice to the Company if the Closing shall not have occurred on or
         before the 180th day following the date of this Agreement by reason of
         the failure of any condition precedent under Section 5.1 or 5.2 hereof
         (unless the failure results primarily from a breach by the Buyer or the
         Transitory Subsidiary of any representation, warranty or covenant
         contained in this Agreement);

                   (e) the Company may terminate this Agreement by giving
         written notice to the Buyer and the Transitory Subsidiary if the
         Closing shall not have occurred on or before the 180th day following
         the date of this Agreement by reason of the failure of any condition
         precedent under Section 5.1 or 5.3 hereof (unless the failure results
         primarily from a breach by the Company of any representation, warranty
         or covenant contained in this Agreement); or

                   (f) the Buyer may terminate this Agreement if (i) the Board
         of Directors of the Company withdraws its recommendation of the Merger
         or modifies such recommendation in a manner adverse to the Buyer, fails
         to reconfirm such recommendation within five business days after a
         request from the Buyer that the Board of



                                         -35-









<PAGE>   36




         Directors do so or fails to reject any proposal relating to an
         Acquisition Transaction made by a party other than the Buyer within
         five business days following the date that such proposal is made.

              6.2 EFFECT OF TERMINATION. Except as set forth in Section 6.3, if
         any Party terminates this Agreement pursuant to Section 6.1, all
         obligations of the Parties hereunder shall terminate without any
         liability of any Party to any other Party, except for any liability of
         any Party for breaches of this Agreement occurring prior to such
         termination.

              6.3 TERMINATION FEE. Notwithstanding Section 6.2, in the event of
         the termination of this Agreement by the Buyer pursuant to (x) Section
         6.1(b) as a result of a breach by the Company of Section 4.3(b) or
         Section 4.7 or (y) Section 6.1(f), the Company shall, immediately upon
         such termination, pay to the Buyer in cash a termination fee in the
         amount of $3,000,000, plus an amount equal to all of the Buyer's
         out-of-pocket expenses incurred in connection with the transactions
         contemplated by this Agreement (including without limitation fees and
         expenses of legal counsel, investment bankers and accountants), whether
         incurred before or after the date of this Agreement ("Buyer Expenses").
         Notwithstanding Section 6.2, in the event of the termination of this
         Agreement by the Buyer pursuant to (i) Section 6.1(b) (other than as a
         result of a breach by the Company of Section 4.3(b) or 4.7) or (ii)
         6.1(d) or by any Party pursuant to Section 6.1(c), the Company shall
         pay to the Buyer in cash, upon demand, a sum equal to the Buyer
         Expenses.


                                     ARTICLE VII

                                     DEFINITIONS

                   For purposes of this Agreement, each of the following defined
         terms is defined in the Section of this Agreement indicated below.

              Defined Term                               Section
              ------------                               -------

              Acquisition Transaction                    4.7
              Affiliate Agreement                        4.8
              Blackout Period                            4.11(e)
              Buyer                                      Introduction
              Buyer Common Stock                         1.5(a)
              Buyer Expenses                             6.3
              Buyer Material Adverse Effect              3.4
              Buyer Prospectus                           3.5(a)
              Buyer Reports                              3.5(a)







                                         -36-





<PAGE>   37










              Certificate of Merger                      1.1
              Certificates                               1.7(a)
              Closing                                    1.2
              Closing Date                               1.2
              Code                                       1.10(a)
              Comdisco                                   1.10(d)
              Company                                    Introduction
              Company Common Stock                       1.5(a)
              Company Registration Statement             2.6
              Company Shares                             1.5(a)
              Company Stockholders                       1.3
              Company Convertible Preferred Shares       1.5(a)
              Conversion Ratio                           1.5(a)
              Disclosure Schedule                        Article II
              Dissenting Shares                          1.6(a)
              Effective Time                             1.1
              Environmental Law                          2.15(a)
              ERISA                                      2.14(a)
              Exchange Act                               3.4
              Exchange Agent                             1.3
              Financial Statements                       2.6
              GAAP                                       2.6
              Governmental Entity                        2.4(b)
              Higher Offer                               4.3(e)
              Holders                                    4.11(a)
              Indemnitee                                 4.11(i)
              Indemnitor                                 4.11(i)
              Intellectual Property                      2.10(a)
              Material Adverse Effect                    2.1
              Material Contract                          2.11
              Materials of Environmental Concern         2.15(b)
              Merger                                     1.1
              Merger Shares                              1.5(a)
              Most Recent Balance Sheet                  2.8
              Offering Memorandum/Information
                 Statement                               4.3(a)
              Options                                    1.10(a)
              Ordinary Course of Business                2.4
              PBS                                        1.10(d)
              Parties                                    Introduction
              Permits                                    2.17
              Registrable Shares                         4.11(a)
              Registration Statement                     4.11(b)
              Regulation D                               2.20
              Requisite Stockholder Approval             2.3




                                         -37-







<PAGE>   38










              SEC                                        2.6
              Security Interest                          2.4
              Securities Act                             2.2
              Special Meeting                            4.3(a)
              Surviving Corporation                      1.1
              Transitory Subsidiary                      Introduction
              Warrants                                   1.10(d)


                                    ARTICLE VIII

                                   MISCELLANEOUS

              8.1 PRESS RELEASES AND ANNOUNCEMENTS. No Party shall issue any
         press release or public disclosure relating to the subject matter of
         this Agreement without the prior written approval of the other Parties;
         PROVIDED, HOWEVER, that any Party may make any public disclosure it
         believes in good faith is required by law or regulation (in which case
         the disclosing Party shall advise the other Parties and provide them
         with a copy of the proposed disclosure and a reasonable opportunity to
         comment thereon prior to making the disclosure).

              8.2 NO THIRD PARTY BENEFICIARIES. This Agreement shall not confer
         any rights or remedies upon any person other than the Parties and their
         respective successors and permitted assigns; PROVIDED, HOWEVER, that
         the provisions in Article I concerning issuance of the Merger Shares,
         in Section 4.11 concerning registration rights and in Section 5.3(f)
         concerning the tax opinion are intended for the benefit of the Company
         Stockholders, the provisions of Section 1.10 are intended for the
         benefit of the holders of Options and the provisions of Section 4.10
         are intended for the benefit of the officers and directors of the
         Company specified therein.

              8.3 ENTIRE AGREEMENT. This Agreement (including the documents
         referred to herein) constitutes the entire agreement among the Parties
         and supersedes any prior understandings, agreements, or representations
         by or among the Parties, written or oral, with respect to the subject
         matter hereof.

              8.4 SUCCESSION AND ASSIGNMENT. This Agreement shall be binding
         upon and inure to the benefit of the Parties named herein and their
         respective successors and permitted assigns. No Party may assign either
         this Agreement or any of its rights, interests, or obligations
         hereunder without the prior written approval of the other Parties;
         provided that the Transitory Subsidiary may assign its rights,
         interests and obligations hereunder to an Affiliate of the Buyer.




                                         -38-








<PAGE>   39










              8.5 NON-SURVIVAL OF REPRESENTATIONS AND WARRANTIES. The respective
         representations and warranties of the Company, the Buyer and the
         Transitory Subsidiary contained in this Agreement shall expire with,
         and be terminated and extinguished upon, the occurrence of the
         Effective Time.

              8.6 COUNTERPARTS. This Agreement may be executed in two or more
         counterparts, each of which shall be deemed an original but all of
         which together shall constitute one and the same instrument.

              8.7 HEADINGS. The section headings contained in this Agreement are
         inserted for convenience only and shall not affect in any way the
         meaning or interpretation of this Agreement.

              8.8 NOTICES. All notices, requests, demands, claims, and other
         communications hereunder shall be in writing. Any notice, request,
         demand, claim, or other communication hereunder shall be deemed duly
         delivered three business days after it is sent by registered or
         certified mail, return receipt requested, postage prepaid, or one
         business day after it is sent via a reputable nationwide overnight
         courier service, in each case to the intended recipient as set forth
         below:

                   If to the Company:                 Copy to:
                   ------------------                 --------

                   ChemGenics Pharmaceuticals         Jeffrey Wiesen, Esq.
                     Inc.                             Mintz, Levin, Cohen,
                   One Kendall Square                   Ferris, Glovsky
                   Building 300                         and Popeo, P.C.
                   Cambridge, MA  02139               One Financial Center
                   Attention:  President              Boston, MA  02111

                   If to the Buyer:                   Copy to:
                   ----------------                   --------

                   Millennium Pharmaceuticals,        Steven D. Singer,
                     Inc.                               Esq.
                   640 Memorial Drive                 Hale and Dorr LLP
                   Cambridge, MA  02139               60 State Street
                   Attention:  President              Boston, MA  02109

                   If to the Transitory Subsidiary:   Copy to:
                   --------------------------------   --------

                   CPI Acquisition Corp.
                   c/o Millennium Pharmaceuticals,    Steven D. Singer,
                     Inc.                               Esq.
                   640 Memorial Drive                 Hale and Dorr LLP
                   Cambridge, MA  02139               60 State Street
                   Attention:  President              Boston, MA  02109




                                         -39-





<PAGE>   40










         Any Party may give any notice, request, demand, claim, or other
         communication hereunder using any other means (including personal
         delivery and telecopy), but no such notice, request, demand, claim, or
         other communication shall be deemed to have been duly given unless and
         until it actually is received by the party for whom it is intended. Any
         Party may change the address to which notices, requests, demands,
         claims, and other communications hereunder are to be delivered by
         giving the other Parties notice in the manner herein set forth.

              8.9  GOVERNING LAW. This Agreement shall be governed by and
         construed in accordance with the internal laws (and not the law of
         conflicts) of the State of Delaware.

              8.10 AMENDMENTS AND WAIVERS. The Parties may mutually amend any
         provision of this Agreement at any time prior to the Effective Time;
         PROVIDED, HOWEVER, that any amendment effected subsequent to the
         Requisite Stockholder Approval shall be subject to the restrictions
         contained in the Delaware General Corporation Law. No amendment of any
         provision of this Agreement shall be valid unless the same shall be in
         writing and signed by all of the Parties. No waiver by any Party of any
         default, misrepresentation, or breach of warranty or covenant
         hereunder, whether intentional or not, shall be deemed to extend to any
         prior or subsequent default, misrepresentation, or breach of warranty
         or covenant hereunder or affect in any way any rights arising by virtue
         of any prior or subsequent such occurrence.

             8.11 SEVERABILITY. Any term or provision of this Agreement that is
         invalid or unenforceable in any situation in any jurisdiction shall not
         affect the validity or enforceability of the remaining terms and
         provisions hereof or the validity or enforceability of the offending
         term or provision in any other situation or in any other jurisdiction.
         If the final judgment of a court of competent jurisdiction declares
         that any term or provision hereof is invalid or unenforceable, the
         Parties agree that the court making the determination of invalidity or
         unenforceability shall have the power to reduce the scope, duration, or
         area of the term or provision, to delete specific words or phrases, or
         to replace any invalid or unenforceable term or provision with a term
         or provision that is valid and enforceable and that comes closest to
         expressing the intention of the invalid or unenforceable term or
         provision, and this Agreement shall be enforceable as so modified after
         the expiration of the time within which the judgment may be appealed.

             8.12 EXPENSES. Except as provided in Sections 6.2 and 6.3 hereof,
         each of the Parties shall bear its own costs and expenses (including
         legal fees and expenses) incurred in connection with this Agreement and
         the transactions contemplated hereby.





                                         -40-







<PAGE>   41










             8.13 SPECIFIC PERFORMANCE. Each of the Parties acknowledges and
         agrees that one or more of the other Parties would be damaged
         irreparably in the event any of the provisions of this Agreement are
         not performed in accordance with their specific terms or otherwise are
         breached. Accordingly, each of the Parties agrees that the other
         Parties shall be entitled to an injunction or injunctions to prevent
         breaches of the provisions of this Agreement and to enforce
         specifically this Agreement and the terms and provisions hereof in any
         action instituted in any court of the United States or any state
         thereof having jurisdiction over the Parties and the matter (subject to
         the provisions of Section 8.14), in addition to any other remedy to
         which it may be entitled, at law or in equity.

             8.14 SUBMISSION TO JURISDICTION. Each of the Parties (a) submits to
         the jurisdiction of any state or federal court sitting in the
         Commonwealth of Massachusetts in any action or proceeding arising out
         of or relating to this Agreement, (b) agrees that all claims in respect
         of the action or proceeding may be heard and determined in any such
         court, and (c) agrees not to bring any action or proceeding arising out
         of or relating to this Agreement in any other court. Each of the
         Parties waives any defense of inconvenient forum to the maintenance of
         any action or proceeding so brought and waives any bond, surety or
         other security that might be required of any other Party with respect
         thereto. Any Party may make service on another Party by sending or
         delivering a copy of the process to the Party to be served at the
         address and in the manner provided for the giving of notices in Section
         8.8. Nothing in this Section 8.14, however, shall affect the right of
         any Party to serve legal process in any other manner permitted by law.

             8.15 CONSTRUCTION. The language used in this Agreement shall be
         deemed to be the language chosen by the Parties hereto to express their
         mutual intent, and no rule of strict construction shall be applied
         against any Party. Any reference to any federal, state, local, or
         foreign statute or law shall be deemed also to refer to all rules and
         regulations promulgated thereunder, unless the context requires
         otherwise.

             8.16 INCORPORATION OF EXHIBITS AND SCHEDULES. The Exhibits and
         Schedules identified in this Agreement are incorporated herein by
         reference and made a part hereof.





                                         -41-





<PAGE>   42





              IN WITNESS WHEREOF, the Parties hereto have executed this
         Agreement as of the date first above written.


                                         MILLENNIUM PHARMACEUTICALS, INC.

                                             
                                         By: /s/ Mark J. Levin
                                            --------------------------------


                                         Title: Chief Executive Officer
                                               -----------------------------

                                         CPI ACQUISITION CORP.


                                         By: /s/ Mark J. Levin
                                            --------------------------------

                                         Title: President
                                               -----------------------------

                                         CHEMGENICS PHARMACEUTICALS INC.


                                         By: /s/ Barry A. Berkowitz, Ph.D.
                                            --------------------------------

                                         Title: Chief Executive Officer
                                               -----------------------------


              The undersigned, being the duly elected Secretary or Assistant
         Secretary of the Transitory Subsidiary, hereby certifies that this
         Agreement has been adopted by a majority of the votes represented by
         the outstanding shares of capital stock of the Transitory Subsidiary
         entitled to vote on this Agreement.

                                         /s/ Steven D. Singer
                                         -----------------------------------
                                         Secretary or Assistant Secretary


              The undersigned, being the duly elected Secretary or Assistant
         Secretary of the Company, hereby certifies that this Agreement has been
         adopted by a majority of the votes represented by the outstanding
         Company Shares entitled to vote on this Agreement.

                                         /s/ Barry A. Berkowitz, Ph.D.
                                         -----------------------------------
                                         Secretary or Assistant Secretary




                                         -42-


<PAGE>   1
                                                                  EXHIBIT 99.1

                [MILLENNIUM PHARMACEUTICALS, INC. LETTERHEAD]
                       

FOR RELEASE JANUARY 20, 1997 4:30 PM EST
- ----------------------------------------

<TABLE>
<S>                                                    <C>
CONTACT: BEVERLY HOLLEY                                ALAN CRANE
         Director of Investor and Public Relations     VP Business Development
         Millennium Pharmaceuticals, Inc.              ChemGenics Pharmaceuticals Inc.
         (617) 679-7480                                (617) 374-9090

         NOONAN/RUSSO COMMUNICATIONS                   FEINSTEIN PARTNERS
         Anthony J. Russo, Ph.D. ext. 202              Robert Gottlieb
         (212) 696-4455                                (617) 577-8110
</TABLE>

                    MILLENNIUM PHARMACEUTICALS AND CHEMGENICS
                         PHARMACEUTICALS AGREE TO MERGE
  -ChemGenics' Technology Platforms Enhance and Forward Integrate Millennium's
                          Drug Discovery Capabilities--

CAMBRIDGE, MA-JANUARY 20, 1997-Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM)
and ChemGenics Pharmaceuticals Inc. today jointly announced that they have
signed a definitive merger agreement whereby Millennium will acquire
privately-held ChemGenics Pharmaceuticals. Both companies view this merger as an
important step in realizing their joint vision of becoming a world leader in
drug discovery, employing an integrated high-throughout drug discovery platform
from gene identification to drug lead.

In addition to a broad technology base in drug discovery, the merged companies
will have seven strategic alliances with five pharmaceutical partners, and a
pipeline of targets and drug leads in a wide range of major disease areas.

Under the terms of the merger agreement, which is expected to close in February
1997, shareholders of ChemGenics will receive approximately 4.8 million
unregistered shares of Millennium common stock in exchange for all of ChemGenics
outstanding stock. In addition, PerSeptive Biosystems, a principal ChemGenics
shareholder, will receive $4.0 million in settlement of a promissory note and
purchase of warrants. ChemGenics shareholders have agreed to a lock-up
arrangement with regard to the Millennium shares to be received in the merger,
which expires in installments through September 30, 1997. Registration of the
shares is expected to occur in June.

"There is remarkable synergy between our companies," said Mark Levin, Chief
Executive Officer of Millennium. "The merged company will have an integrated
drug discovery platform that spans gene discovery to drug lead compounds. Our
merged technologies and respective pipelines create a wealth of new business
opportunities that encompass genes, targets, leads and technology." He noted,
"The merger is the first of several steps designed to build value in areas where
Millennium has retained rights, including small

                                      l of 4

<PAGE>   2


MILLENNIUM AND CHEMGENICS AGREE TO MERGE

molecule drugs, biologics and predictive medicine. Specifically, over the last
several years Millennium has retained significant rights to small molecule
targets across all disease areas, and this will allow us to begin screening our
own targets with our own libraries this year," he added.

Mr. Levin continued, "Barry Berkowitz and Bill Timberlake have built a premier,
experienced scientific and drug discovery team at ChemGenics and we expect them
and other members of the team to play important roles at Millennium."

"The merger of these two companies will allow us to accelerate the drug
discovery process across an enormous range of therapeutic areas," commented
Barry Berkowitz, Ph.D., President and Chief Executive Officer of ChemGenics.
"Combining our technologies and people with Millennium's outstanding
organization will position us to be world leaders in drug discovery genomics
with strong proprietary assets and an outstanding set of pharmaceutical
alliances," he said. "Through these strategic alliances, Millennium will have
over $300 million in committed funding, and a total of over $400 million in
funding, including payments for the achievement of milestones."

The key synergies expected to be generated by the merger include:

DRUG LEAD DISCOVERY. ChemGenics brings to Millennium state-of-the-art, high
throughout screening capabilities that will allow Millennium to integrate
forward toward the development of small molecule drug leads in all of the areas
where the company has retained rights. In collaboration with its pharmaceutical
partners, ChemGenics has validated its screening technology in combinatorial,
synthetic chemical and natural products libraries.

PROPRIETARY DRUG SOURCE. ChemGenics has a proprietary natural products drug
source and access to compound libraries through corporate alliances. These
complement the combinatorial and pharmaceutical compound libraries that
Millennium has accessed through its collaborations with Eli Lilly and
Wyeth-Ayerst. The natural products drug source is based primarily on a large
(over 50,000), diverse collection of fungi, historically one of the most
productive sources of new therapeutic compounds. ChemGenics has developed
biocombinatorial methods involving genetic engineering to enhance chemical
diversity.

BROADENED STRATEGIC ALLIANCES AND PIPELINE. The merger broadens the scope of
Millennium's therapeutic research to include anti-infectives. ChemGenics has a
major strategic alliance with Pfizer in the area of human antifungal drugs and
in December 1996 entered into a major collaboration with Wyeth-Ayerst in the
area of antibacterial drugs.

                                     2 of 4

<PAGE>   3



MILLENNIUM AND CHEMGENICS AGREE TO MERGE

The two-year old Pfizer collaboration has resulted in the discovery both of
novel antifungal targets and early lead compounds. ChemGenics also has drug
discovery programs in peptic ulcer disease (H. pylori) and in areas that are
complementary to Millennium's established efforts, including cancer,
inflammation and immunoregulation.

GENE AND DRUG TARGET DISCOVERY. ChemGenics adds to Millennium microbial genetics
technologies that have application in gene and target discovery across all
disease states. Along with Millennium's expertise in human and mouse genetics,
the microbial gene technologies will significantly enhance Millennium's ability
to identify genes, elucidate valuable drug targets and configure drug screening
assays. ChemGenics' scientists and advisors include worldwide leaders in
microbial molecular biology and genetics, including scientific advisory board
members, Gerald R. Fink, Ph.D., Director of the Whitehead Institute for
Biomedical Research, and Richard Losick, Ph.D., Chairman, Department of
Molecular and Cellular Biology at Harvard; and William Timberlake, Ph.D.,
ChemGenics' Executive Vice President for Research.

DRUG DISCOVERY TECHNOLOGY RELATIONSHIPS. Millennium's vision of integrated, high
throughout drug discovery (gene to lead compound) incorporates a wide range of
new technologies to increase the capacity and quality and reduce important
bottlenecks in the process. ChemGenics has an agreement with PerSeptive
Biosystems through which it acquired assets and technology, including royalty
free licenses to all present and future PerSeptive technology for application in
drug discovery. PerSeptive is a leading developer and supplier of technology,
advanced workstations, chemistry and other tools for the biotechnology industry.
Millennium plans to incorporate these and future technologies through
relationships with others.

Millennium employs large-scale genetics, genomics, and bioinformatics in an
integrated, broad-based drug discovery program applicable to all major human
diseases. Independently and in strategic alliances with leading pharmaceutical
companies, the Company has focused its research efforts on identifying and
elucidating the function of genes responsible for diseases that affect millions
of individuals and are underserved by current therapeutic alternatives. These
diseases include obesity, type II diabetes, atherosclerosis, asthma, cancer and
diseases of the central nervous system. Millennium's principal objective is to
use its drug discovery platform to enable and accelerate the discovery and
development of new, proprietary therapeutic and diagnostic products capable of
addressing these diseases at their root causes, rather than simply identifying
and treating their symptoms. Headquartered in Cambridge, Massachusetts,
Millennium currently employs over 275 people. Subsequent to the merger, the
combined company will employ over 345 people.

                                     3 of 4

<PAGE>   4


This press release contains forward-looking statements that involve a number of
risks and uncertainties. Among the factors that could cause actual results to
differ materially from those indicated in such forward looking statements
include: difficulties that may be encountered in integrating the businesses,
technologies and personnel of Millennium and ChemGenics following the merger;
uncertainties relating to the gene identification, drug discovery and clinical
development processes; changes in relationships with strategic partners and
uncertainties relating to the performance by strategic partners of critical
activities under the collaborative agreements with Millennium and ChemGenics;
uncertainties related to governmental regulation; and other risk factors
detailed from time to time in the Company's periodic reports and registration
statements filed with the Securities and Exchange Commission.

                                       ###

  

<PAGE>   1
                                                                   EXHIBIT 99.2


                [MILLENNIUM PHARMACEUTICALS, INC. LETTERHEAD]
                     

FOR IMMEDIATE RELEASE
- ---------------------

CONTACT: BEVERLY HOLLEY                                HARRY ARADER 
         Director of Investor and Public Relations     Chief Financial Officer 
         (617) 679-7480                                (617) 679-7165

             MILLENNIUM REPORTS 1996 FINANCIAL RESULTS AND ANNOUNCES
              COMPLETION OF MERGER WITH CHEMGENICS PHARMACEUTICALS

CAMBRIDGE, MA--FEBRUARY 11, 1997--Millennium Pharmaceuticals, Inc. (Nasdaq:
MLNM) today reported financial results for the fourth quarter and year ended
December 31, 1996, and announced completion of its merger with ChemGenics
Pharmaceuticals Inc.

For the quarter, Millennium reported a net loss of $3,772,000 or $0.16 a share,
compared to net income of $8,806,000 or $0.46 per share in the fourth quarter of
1995. Revenues under the Company's strategic alliances were $9,524,000 for the
fourth quarter of 1996, compared to $14,880,000 for the same period in 1995. The
fourth quarter 1995 revenues were high due to license fees associated with
Millennium's research collaborations. Interest income increased to $627,000 for
the fourth quarter of 1996, compared to $182,000 for the fourth quarter of 1995.
Expenditures on research and development for the fourth quarter of 1996 were
$10,831,000 versus $5,235,000 for the fourth quarter of 1995.

For the year-ended December 31, 1996, the Company reported a net loss of
$8,768,000 or $0.39 per share, compared to net income of $1,284,000 or $0.07 per
share for the year-ended December 31, 1995. Revenues from strategic alliances
increased to $31,764,000 compared to $22,880,000 in 1995, reflecting the
financial commitments from Millennium's multiple strategic partners. Interest
income increased to $3,131,000 for the year, compared to $358,000 in 1995,
primarily due to the influx of cash from the Company's initial public offering
in May of 1996. Expenditures on research and development increased to
$34,803,000, compared to $17,838,000 in 1995. The Company ended 1996 with
$64,967,000 in cash, cash equivalents and investments.

Payments under strategic alliance and licensing arrangements have historically
and will continue to be subject to significant fluctuations in both timing and
amounts. This will result in periods of profitability and periods of losses
making it difficult to compare results of operations from one period to another.

"Our financial performance in 1996 was in line with our strategic plan,"
commented Harry F. Arader, Jr., Chief Financial Officer. "In 1996 we completed
an initial public offering with net proceeds of approximately $58 million, and
signed strategic alliances with Wyeth-Ayerst and Eli Lilly. We also committed
significant resources to the development of our drug discovery platform, an
investment that we expect will yield an increasingly broad array of drug
development candidates in the future."

                                     1 of 3



  
<PAGE>   2

MILLENNIUM ANNOUNCES 1996 FINANCIAL RESULTS AND COMPLETION 
OF MERGER WITH CHEMGENICS

Separately, the Company also announced today that it has completed a merger with
ChemGenics Pharmaceuticals Inc. of Cambridge, MA. The transaction will be
recorded as a purchase for accounting purposes and will result in a substantial
charge to first quarter operating results due to the write-off of acquired
in-process research and development.

The merger, which was announced on January 20, 1997, was consummated by the
exchange of 0.2374 shares of common stock of Millennium for each outstanding
share of common stock of ChemGenics. Millennium issued approximately 4.8 million
shares of common stock in exchange for all outstanding shares of common stock of
ChemGenics. The Millennium shares will be unregistered when issued and will be
subject to certain restrictions on sale which expire in increments through
September, 1997. The Company expects to file a registration statement in June
1997 relating to the shares being issued to ChemGenics. In addition, PerSeptive
Biosystems, a principal shareholder of ChemGenics, received $4.0 million from
ChemGenics in settlement of a promissory note and repurchase of warrants
previously issued by ChemGenics to PerSeptive.

Millennium employs large-scale genetics, genomics, high throughput screening and
bioinformatics in an integrated, broad-based drug discovery program applicable
to all major human diseases. Independently and in strategic alliances with
leading pharmaceutical companies, the Company has focused its research efforts
on diseases that affect millions of individuals and are underserved by current
therapeutic alternatives. These diseases include obesity, type II diabetes,
atherosclerosis, asthma, cancer, diseases of the central nervous system,
bacterial diseases and fungal diseases. Millennium's principal objective is to
use its drug discovery platform to enable and accelerate the discovery and
development of new, proprietary therapeutic and diagnostic products capable of
addressing these diseases at their root causes, rather than simply identifying
and treating their symptoms. Headquartered in Cambridge, Massachusetts,
Millennium currently employs over 350 people.

This press release contains forward-looking statements that involve a number of
risks and uncertainties. Among the factors that could cause actual results to
differ materially from those indicated in such forward looking statements
include: difficulties that may be encountered in integrating the businesses,
technologies and personnel of Millennium and ChemGenics following the merger;
uncertainties relating to the gene identification, drug discovery and clinical
development processes; changes in relationships with strategic partners and
uncertainties relating to the performance by strategic partners of critical
activities under the collaborative agreements with Millennium and ChemGenics;
uncertainties related to governmental regulation; and other risk factors
detailed from time to time in the Company's periodic reports and registration
statements filed with the Securities and Exchange Commission.

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