MILLENNIUM PHARMACEUTICALS INC
424B3, 2000-11-16
PHARMACEUTICAL PREPARATIONS
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<PAGE>


                                                 Filed pursuant to Rule 424B3

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED APRIL 27, 2000)

                        MILLENNIUM PHARMACEUTICALS, INC.

       $400,000,000 Principal Amount 5.50% Convertible Subordinated Notes
                              Due January 15, 2007

     9,507,840 Shares of Common Stock issuable upon conversion of the Notes

      423,108 Shares of Common Stock issuable upon exercise of outstanding
                       warrants to purchase common stock

                           --------------------------

         This prospectus supplement relates to resales by selling holders of:

         -        our 5.50% Convertible Subordinated Notes due January 15, 2007;

         -        our common stock into which the notes are convertible; and

         -        our common stock issuable upon exercise of warrants to
                  purchase our common stock held by GATX Capital Corporation and
                  MM Ventures

         This prospectus supplement should be read in conjunction with the
prospectus dated April 27, 2000, which is to be delivered with this prospectus
supplement.

         SEE "RISK FACTORS" BEGINNING ON PAGE 6 OF THE PROSPECTUS TO READ ABOUT
FACTORS YOU SHOULD CONSIDER BEFORE BUYING THE NOTES OR OUR COMMON STOCK.

                                              ---------------------

         Neither the Securities and Exchange Commission nor any other regulatory
body has approved or disapproved of these securities or passed upon the accuracy
or adequacy of this prospectus. Any representation to the contrary is a criminal
offense.

                              ---------------------

         The information in the table appearing in the prospectus under the
heading "Selling Holders" is superseded in part by the information appearing in
the following table:

<TABLE>
<CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>
Amoco Corp.               656         656            0            0        15,592      15,592              0              0
Master Trust

Arkansas                2,132       2,132            0            0        50,676      50,676              0              0
Teachers
Retirement
System

<PAGE>


<CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>

Associated                450         450            0            0        10,696      10,696              0              0
Electric & Gas
Insurance
Services Limited

Baptist Health            103         103            0            0         2,448       2,448              0              0
of South Florida

Boston Museum              83          83            0            0         1,972       1,972              0              0
of Fine Arts

Champion                  393         393            0            0         9,341       9,341              0              0
International
Corp.

City University            87          87            0            0         2,067       2,067              0              0
of New York

Credit Suisse           2,818       2,818            0            0        66,982      66,982              0              0
First Boston
Corporation

David Lipscomb            105         105            0            0         2,495       2,495              0              0
University
General
Endowment

Deephaven              10,886      10,886            0            0       258,755     258,755              0              0
Domestic
Convertible
Trading Ltd

Deutsche Bank          30,700      30,700            0            0       729,726     729,726              0              0
Securities Inc.

Donaldson,                575         575            0            0        13,667      13,667              0              0
Lufkin &
Jenrette
Securities Corp.

Engineers Joint           289         289            0            0         6,869       6,869              0              0
Pension Fund

EQAT Alliance           2,955       2,955            0            0        70,239      70,239              0              0
Growth & Income


                                       2
<PAGE>


 <CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>

Equitable Life          1,925       1,925            0            0        45,756      45,756              0              0
Assurance
Separate
Account -
Convertible

EQAT Alliance           1,605       1,605            0            0        38,150      38,150              0              0
Growth Investors

Fidelity                8,250       8,250            0            0       196,099     196,099              0              0
Financial
Trust:
Fidelity
Convertible &
Securities Fund

Forest                    109         109            0            0         2,590       2,590              0              0
Alternative
Strategies
Fund II LP A5M

Forest Fulcrum            900         900            0            0        21,392      21,392              0              0
Fund LP

Forest Global           6,625       6,625            0            0       157,473     157,473              0              0
Convertible
Fund A-5

Goldman Sachs          16,276      16,276            0            0       386,874     386,874              0              0
and Company

Grady Hospital            136         136            0            0         3,232       3,232              0              0

Helix                   1,065       1,065            0            0        25,314      25,314              0              0
Convertible
Opportunities
Fund Ltd.

Helix                   3,095       3,095            0            0        73,566      73,566              0              0
Convertible
Opportunities,
L.P.

HBK Master Fund         2,500       2,500            0            0        59,424      59,424              0              0
L.P.

Jeffries & Co.            656         656            0            0        15,592      15,592              0              0
Inc.

JAS Securities          1,500       1,500            0            0        35,654      35,654              0              0


                                       3
<PAGE>


<CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>

J.P. Morgan             7,054       7,054            0            0       167,670     167,670              0              0
Securities Inc.

KBC Financial           2,000       2,000            0            0        47,539      47,539              0              0
Products

Key Asset                 350         350            0            0         8,319       8,319              0              0
Management,
Inc., as Agent
for the Victory
Convertible
Securities Fund

Lehman                    148         148            0            0         3,517       3,517              0              0
Brothers, Inc.

Local                      56          56            0            0         1,331       1,331              0              0
Initiatives
Support
Corporation

Lord Abbett             7,600       7,600            0            0       180,648     180,648              0              0
Bond Debenture
Fund

Lyxor Master            1,000       1,000            0            0        23,769      23,769              0              0
Fund c/o Forest
Investment
Management LLC

Maryland State          3,397       3,397            0            0        80,745      80,745              0              0
Retirement
System

McMahan                   530         530            0            0        12,597      12,597              0              0
Securities
Co.,  L.P.

MFS Total               2,000       2,000            0            0        47,539      47,539              0              0
Return Fund

New Orleans               139         139            0            0         3,303       3,303              0              0
Firefighters


                                       4
<PAGE>


<CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>

Nicholas-Applegate        738         738            0            0        17,541      17,541              0              0
Convertible Fund

Occidental                240         240            0            0         5,704       5,704              0              0
Petroleum

Physicians Life           226         226            0            0         5,371       5,371              0              0

Pilgrim                 2,765       2,765            0            0        65,722      65,722              0              0
Convertible Fund

Q Opportunity           3,500       3,500            0            0        83,193      83,193              0              0
Fund Ltd.

Robertson               8,000       8,000            0            0       190,156     190,156              0              0
Stephens

S G Cowen               7,000       7,000            0            0       166,387     166,387              0              0
Securities Corp.

Sagamore Hill           6,250       6,250            0            0       148,560     148,560              0              0
Hub Fund Ltd.

San Diego City            580         580            0            0        13,786      13,786              0              0
Retirement

San Diego               1,408       1,408            0            0        33,467      33,467              0              0
County
Convertible

Shell Pension             376         376            0            0         8,937       8,937              0              0
Trust

The Common Fund           560         560            0            0        13,310      13,310              0              0
FAO Absolute
Return Fund

The Frist                 285         285            0            0         6,774       6,774              0              0
Foundation

Tribeca                29,000      24,000            0            0       570,470     570,470              0              0
Investments LLC

Trusco Capital          1,400       1,400            0            0        33,277      33,277              0              0
Management


                                       5
<PAGE>


<CAPTION>

                                                                         Number of
                                                                         Shares of                      Number of     Percentage
                                                         Percentage     Common Stock                    Shares of    of Shares of
                     Notes                    Notes      of the Notes   Beneficially   Number of       Common Stock   Common Stock
                  Beneficially   Notes     Beneficially  Beneficially      Owned       Shares of       Beneficially   Beneficially
  Selling         Owned Prior    Offered   Owned After   Owned After     Prior to     Common Stock     Owned After    Owned After
Securityholder    to Offering    Hereby    Offering (1)  the Offering    Offering    Offered Hereby    Offering(1)    Offering(1)
                  (in $1,000)  (in $1,000) (in $1,000)
<S>               <C>          <C>         <C>           <C>            <C>          <C>               <C>            <C>

TQA Master Fund         1,700       1,700            0            0        40,408      40,408              0              0

TQA Master Plus         1,175       1,175            0            0        27,929      27,929              0              0
Fund

Wake Forest               692         692            0            0        16,448      16,448              0              0
University

Writers                   179         179            0            0         4,254       4,254              0              0
Guild-Industry
Health Fund

Zurich HFR                570         570            0            0        13,548      13,548              0              0
Master Hedge
Fund Index, Ltd.
</TABLE>


         (1) We do not know if, when or in what amounts a selling securityholder
may offer securities for sale and we do not know that the selling
securityholders will sell any or all of the securities offered hereby. Because
the selling securityholders may offer all or some of the securities pursuant to
this prospectus, and because there are currently no other agreements,
arrangements or understandings with respect to the sale of any of the securities
that will be held by the selling securityholders, no estimate can be given as to
the amount of the securities that will be held by the selling securityholders
after completion of the offering made by this prospectus. However, for purposes
of this table, we have assumed that, after completion of the offering, no
securities will be held by the selling securityholders.



          The date of this prospectus supplement is November 16, 2000.



                                       6



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