IMPATH INC
S-3, 1998-03-13
MEDICAL LABORATORIES
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<PAGE>
 
     As filed with the Securities and Exchange Commission on March 13, 1998.
                                                           Registration No. 333-
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                   IMPATH INC.
             (Exact name of registrant as specified in its charter)

             Delaware                               13-3459685
  (State or other jurisdiction                   (I.R.S. Employer
 of incorporation or organization)            Identification Number)

                              521 West 57th Street
                            New York, New York 10019
                                 (212) 698-0300
               (Address, including zip code, and telephone number,
        including area code, of registrant's principal executive offices)

                               Anu D. Saad, Ph.D.
                                  President and
                             Chief Executive Officer
                                   IMPATH Inc.
                              521 West 57th Street
                            New York, New York 10019
                                 (212) 698-0300

                                    Copy to:

                              John J. Butler, Esq.
                                 Haythe & Curley
                                 237 Park Avenue
                            New York, New York 10017
                                 (212) 880-6000

            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                  Approximate date of commencement of proposed
                sale to the public: As soon as practicable after
                 this Registration Statement becomes effective.

         If the only securities  being registered on this Form are to be offered
pursuant to dividend or interest  reinvestment plans, please check the following
box. |_|

         If any of the  securities  being  registered  on  this  Form  are to be
offered  on a  delayed  or  continuous  basis  pursuant  to Rule 415  under  the
Securities Act of 1933,  other than  securities  offered only in connection with
dividend or interest reinvestment plans, check the following box. |X|

         If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list  the  Securities  Act  registration  statement  number  of the  earlier
effective registration statement for the same offering. |_| Not applicable.

         If this  Form is a  post-effective  amendment  filed  pursuant  to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act  registration   statement  number  of  the  earlier  effective  registration
statement for the same offering. |_| Not applicable.

<TABLE>
<CAPTION>
                                                  CALCULATION OF REGISTRATION FEE
====================================================================================================================================

                                                                    Proposed              
                                                                    maximum               
Title of each class of                          Amount to be     offering price      aggregate offering         Amount of
securities to be registered                      registered      per share(1)            price(1)           registration fee
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                             <C>              <C>                 <C>                     <C>    
Common Stock ($.005 par value)...........          20,000
                                                   shares            $34.1875                 $683,750               $201.71
====================================================================================================================================
</TABLE>

(1) Computed in  accordance  with Rule 457(c) under the  Securities  Act of 1933
based upon the average of the high and low prices for the registrant's shares of
Common  Stock  ($.005 par value) as  reported on the Nasdaq  National  Market on
March 6, 1998.

         The registrant hereby amends this  Registration  Statement on such date
or dates as may be necessary to delay its  effective  date until the  registrant
shall file a further amendment which specifically  states that this Registration
Statement shall  thereafter  become effective in accordance with Section 8(a) of
the Securities  Act of 1933 or until this  Registration  Statement  shall become
effective on such date as the Commission,  acting pursuant to said Section 8(a),
may determine.
<PAGE>
 
================================================================================
Information   contained  herein  is  subject  to  completion  or  amendment.   A
registration  statement  relating  to these  securities  has been filed with the
Securities  and Exchange  Commission.  These  securities may not be sold nor may
offers to buy be accepted prior to the time the registration  statement  becomes
effective.  This  prospectus  shall  not  constitute  an  offer  to  sell or the
solicitation of an offer to buy nor shall there be any sale of these  securities
in any State in which such offer,  solicitation  or sale would be unlawful prior
to registration or qualification under the securities laws of any such State.
================================================================================


                 Subject to Completion, dated March 13, 1998
 
Prospectus

                                  20,000 Shares

                                   IMPATH INC.

                                  Common Stock
                                ($.005 par value)







The 20,000  shares of Common  Stock,  $.005 par value (the "Common  Stock"),  of
IMPATH Inc.  ("IMPATH" or the "Company") offered hereby may be sold from time to
time by certain  security  holders of the Company (the "Selling  Stockholders").
See "Selling  Stockholders." All of such shares are issuable upon the conversion
of currently exercisable warrants held by the Selling Stockholders.



The Company  will not receive any proceeds  from the sale of the shares  offered
hereby by the Selling  Stockholders,  except that it will receive  $348,750 upon
the exercise of the  warrants.  All expenses  incurred in  connection  with this
offering are being borne by the Company, other than any commissions or discounts
paid or allowed by the Selling Stockholders to underwriters, dealers, brokers or
agents.



The Selling  Stockholders have not advised the Company of any specific plans for
the  distribution of the shares offered hereby,  but it is anticipated  that the
shares may be sold from time to time in  transactions  (which may include  block
transactions)   on  the  Nasdaq  National  Market  at  the  market  prices  then
prevailing.  Sales  of the  shares  offered  hereby  may  also be  made  through
negotiated  transactions or otherwise.  The Selling Stockholders and the brokers
and dealers through which the sales of the shares offered hereby may be made may
be deemed to be "underwriters" within the meaning of the Securities Act of 1933,
as amended (the "Securities Act"), and their commissions and discounts and other
compensation  may be  regarded  as  underwriters'  compensation.  See  "Plan  of
Distribution."



The Common Stock is quoted on the Nasdaq National Market under the symbol
"IMPH."

SEE "RISK  FACTORS" ON PAGES 4 TO 8 FOR A  DISCUSSION  OF CERTAIN  FACTORS  THAT
SHOULD BE  CONSIDERED  BY  PROSPECTIVE  INVESTORS  IN THE COMMON  STOCK  OFFERED
HEREBY.



THESE  SECURITIES  HAVE NOT BEEN APPROVED OR  DISAPPROVED  BY THE SECURITIES AND
EXCHANGE  COMMISSION OR ANY STATE  SECURITIES  COMMISSION NOR HAS THE SECURITIES
AND  EXCHANGE  COMMISSION  OR ANY STATE  SECURITIES  COMMISSION  PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.








March   , 1998.
<PAGE>
 
                             ADDITIONAL INFORMATION

     The Company has filed with the  Securities  and  Exchange  Commission  (the
"Commission"),  Washington, D.C., a Registration Statement on Form S-3 under the
Securities  Act of 1933 (the  "Securities  Act")  with  respect to the shares of
Common Stock  offered  hereby (as amended and  supplemented,  the  "Registration
Statement").  This  Prospectus does not contain all of the information set forth
in the Registration  Statement and the exhibits thereto. For further information
pertaining  to the  Company  and the  shares of  Common  Stock  offered  hereby,
reference is made to such Registration  Statement,  including the exhibits filed
therewith.  All of these documents may be inspected without charge at the Public
Reference  Section of the principal office of the Commission at Judiciary Plaza,
450  Fifth  Street,  N.W.,  Room  1024,  Washington,   D.C.  20549  and  at  the
Commission's  regional offices located at Seven World Trade Center,  Suite 1300,
New York,  New York  10048 and  Northwestern  Atrium  Center,  500 West  Madison
Street, Suite 1400, Chicago,  Illinois 60661, and copies may be obtained by mail
from the Public  Reference  Section of the  Commission at Judiciary  Plaza,  450
Fifth Street, N.W., Room 1024,  Washington,  D.C. 20549 at prescribed rates. The
Commission  also  maintains a Web site at  http://www.sec.gov  that contains the
Registration  Statement and the exhibits  thereto.  The statements  contained in
this  Prospectus  concerning  any  contract  or  document  are  not  necessarily
complete;   where  such  contract  or  other  document  is  an  exhibit  to  the
Registration Statement,  each such statement is qualified in all respects by the
provisions of such exhibit.

                                   ----------

     The Company  furnishes  its  stockholders  with annual  reports  containing
financial statements audited by independent accountants for each fiscal year and
quarterly  reports for the first three fiscal  quarters of each year  containing
unaudited summary financial information.


                                   ----------

     The Company is subject to the informational  requirements of the Securities
Exchange Act of 1934 (the  "Exchange  Act") and in  accordance  therewith  files
reports,  proxy  and  information  statements  and  other  information  with the
Commission. Such reports, proxy and information statements and other information
can be inspected  and copied at the Public  Reference  Section of the  principal
office of the Commission at Judiciary Plaza, 450 Fifth Street,  N.W., Room 1024,
Washington,  D.C. 20549, and at the Commission's regional offices at Seven World
Trade  Center,  Suite 1300,  New York,  New York 10048 and  Northwestern  Atrium
Center, 500 West Madison Street, Suite 1400, Chicago, Illinois 60661, and copies
of such  materials  may be  obtained  from the Public  Reference  Section of the
Commission at Judiciary Plaza, 450 Fifth Street, N.W., Washington, D.C. 20549 at
prescribed rates. The Commission also maintains a Web site at http://www.sec.gov
that contains  reports,  proxy and information  statements and other information
regarding  the Company.  The Common Stock of the Company is traded on the Nasdaq
National Market and, in accordance therewith,  the Company files reports,  proxy
statements and other information with The Nasdaq Stock Market, Inc.

                 INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

     The Company's  Annual  Report on Form 10-K for the year ended  December 31,
1997  and  the  description  of the  Common  Stock  contained  in the  Company's
Registration  Statement on Form 8-A, as amended, all of which have been filed by
the  Company  with  the  Commission,  are  incorporated  by  reference  in  this
Prospectus.

     In addition,  all documents filed by the Company pursuant to Section 13(a),
13(c), 14 or 15(d) of the Exchange Act subsequent to the date of this Prospectus
and prior to the termination of the offering of the Common Stock hereunder shall
be deemed to be  incorporated  herein by reference  and to be a part hereof from
the date of filing of such  documents.  Any statement  contained in any document
incorporated or deemed to be incorporated by reference herein shall be deemed to
be modified or superseded  for purposes of this  Prospectus to the extent that a
statement  contained  herein or in any other  subsequently  filed document which
also  is or is  deemed  to be  incorporated  by  reference  herein  modifies  or
supersedes such statement. Any such statement so

                                       2
<PAGE>
 
modified or superseded shall not be deemed, except as modified or superseded, to
constitute a part of this Prospectus.

     The Company hereby  undertakes to provide  without charge to each person to
whom a copy of this Prospectus is delivered, upon the written or oral request of
any such person, a copy of any of the above  documents.  Such requests should be
addressed to the  Director of Investor  Relations,  IMPATH  Inc.,  521 West 57th
Street, New York, New York 10019 (Telephone: 212-698-0300).


                                   THE COMPANY

     The Company is a Delaware  corporation  with executive  offices at 521 West
57th Street,  New York, New York 10019, and its telephone number at that address
is 212-698-0300.

                                       3
<PAGE>
 
                                  RISK FACTORS

     Prospective  investors in the shares of Common Stock offered  hereby should
consider  carefully  the  following  risk  factors,  in  addition  to the  other
information contained,  or incorporated by reference,  in this Prospectus.  This
Prospectus   contains   forward-looking   statements  which  involve  risks  and
uncertainties.  The Company's actual results may differ  significantly  from the
results discussed in the  forward-looking  statements.  Factors that might cause
such a  difference  include,  but are not limited to,  those  discussed in "Risk
Factors",  as well as those discussed  elsewhere or incorporated by reference in
this  Prospectus.  Readers are  cautioned  not to place undue  reliance on these
forward-looking statements,  which speak only as of the date hereof. The Company
undertakes  no  obligation  to release  publicly the results of any revisions to
these  forward-looking  statements  which  may be  made  to  reflect  events  or
circumstances   after  the  date  hereof  or  to  reflect  the   occurrence   of
unanticipated events.


RISKS ASSOCIATED WITH MANAGING GROWTH

     The Company  has  experienced  significant  growth as total  revenues  have
increased at an average annual growth rate of approximately 50% between 1993 and
1997.  The  Company's   continued  growth  of  case  volume,   addition  of  new
technologies  and  expansion  into the  outpatient  market  have  placed and may
continue  to place  significant  demands on the  Company's  technical  services,
support operations,  sales and administrative  personnel and other resources. To
manage this  growth  effectively,  the  Company  will be required to continue to
improve  its  operational,   financial  and  management   information   systems,
procedures  and controls,  and to hire and train new  executive,  scientific and
other  personnel  without  adversely  affecting  the  quality  of the  Company's
services. There can be no assurance that the Company will be able to continue to
manage its growth  successfully,  and any failure to do so could have a material
adverse effect on the Company's business and financial  performance.  There also
can be no assurance  that the Company  will be able to maintain  its  historical
rate of growth.

RISKS ASSOCIATED WITH ACQUISITION STRATEGY

         The  Company's  objective is to become the leading  provider of a broad
range of  cancer  management  information  services,  including  diagnostic  and
prognostic analyses.  To date, the Company's business has consisted primarily of
providing patient-specific  diagnostic and prognostic information based upon the
testing of tissue  specimens and the  customized  analysis of test results.  The
Company intends to pursue strategic  acquisitions if such  acquisitions  further
aspects of the Company's  strategic objective outlined above. To the extent that
the Company's strategy is dependent upon acquisitions, there can be no assurance
that suitable  acquisition  candidates  will be identified by the Company in the
future,  that, if required,  suitable financing for any such acquisitions can be
obtained  by the  Company,  or that any such  acquisitions  will  occur.  If the
Company  successfully  completes a strategic  acquisition or  acquisitions,  the
financial performance of the Company will be subject to various risks associated
with the  acquisition of  businesses.  In addition,  if the businesses  acquired
operate outside of the United States,  such  operations  would be subject to the
risks normally  associated with foreign operations,  including,  but not limited
to, currency  fluctuations  and the modification or introduction of governmental
policies with potentially  adverse effects.  There can be no assurance that such
acquisitions  will not have an  adverse  effect on the  business  operations  or
profitability of the Company.

DEPENDENCE ON KEY MANAGEMENT AND QUALIFIED PERSONNEL

         The Company is dependent  upon the efforts of its  executive  officers,
key employees and medical professionals. The loss of the services of one or more
members of its senior  management  or one or more  medical  professionals  could
impede the achievement of the Company's development objectives. In addition, the
Company's  growth  strategy will require  additional  skill and  expertise,  the
addition of new management personnel and the development of additional expertise
by existing management personnel. The loss of, or

                                       4
<PAGE>
 
failure to recruit, scientific,  technical and managerial personnel could have a
material adverse effect on the Company.

REIMBURSEMENT

         The  Company  typically  bills  third-party  payors,  such  as  private
insurance plans, managed care plans and governmental programs (i.e.,  Medicare),
as well as  hospitals,  for its  services.  Although  these  third-party  payors
currently  generate higher  reimbursement  rates per case, they are increasingly
negotiating  prices  with the goal of lowering  unit  reimbursement  rates.  The
Company expects these pricing  pressures to cause reduced pricing on average for
tests in future periods.

         In 1995, 1996 and 1997,  approximately 24%, 25% and 25%,  respectively,
of the  Company's  net revenues for  diagnostic  and  prognostic  services  were
derived from analyses  performed for  beneficiaries  under the Medicare program.
The Company accepts Medicare  reimbursement as payment in full for its services,
subject to applicable  co-payments and deductibles.  Medicare may  retroactively
audit and review its payments to the  Company,  and may  determine  that certain
payments for services must be returned.  Significant disapprovals of payment for
any of the Company's services by various carriers,  including Medicare,  private
insurance  and  managed  care,  reductions  or  delays in the  establishment  of
reimbursement  rates,  and carrier  limitations on the coverage of the Company's
services could have a material  adverse effect on the Company's future revenues.
The services  furnished by the Company are characterized for the purposes of the
Medicare program as physician pathology services.

         Any  future   changes  in  government  and  other   third-party   payor
reimbursement  which may come  about as a result  of  enactment  of health  care
reform or of  deficit-reduction  legislation will also be likely to continue the
downward pressure on prices, and make the market for cancer analytical  services
more  competitive.  Because of the uncertainties  about the nature,  content and
timing of any reform initiative,  the Company is currently unable to predict the
ultimate impact thereof on the Company.

GOVERNMENT REGULATION

         As a provider of  health-care-related  services, the Company is subject
to  extensive  and  frequently  changing  federal,  state and local  regulations
governing licensure,  billing,  financial relationships,  referrals,  conduct of
operations,   purchases  of  existing   businesses,   cost-containment,   direct
employment of licensed  professionals by business corporations and other aspects
of the Company's  business  relationships.  Federal and state  certification and
licensure  programs  establish   standards  for  the  day-to-day   operation  of
facilities such as the Company's.  Compliance with such standards is verified by
periodic inspections and requires participation in proficiency testing programs.
No assurances  can be given that the Company's  facilities  will pass all future
inspections  conducted to ensure compliance with federal or any other applicable
licensure or certification laws.

         Existing federal laws governing federal health care programs, including
Medicare,  as  well  as  some  state  laws,  regulate  certain  aspects  of  the
relationship  between health care  providers,  including the Company,  and their
referral sources,  including  physicians,  hospitals and other  facilities.  The
Social Security Act, and the anti-kickback  and self-referral  rules thereunder,
prohibit  providers and others from soliciting,  offering,  receiving or paying,
directly or indirectly,  any remuneration in return for either making a referral
for a service or item which is covered  under any federal  health  care  program
(including Medicare),  or ordering any such covered service or item and prohibit
physicians, subject to certain exceptions, from making such referrals to certain
entities  in which they have an  investment  interest  or with which they have a
compensation  arrangement.  Violation of these  prohibitions  is  punishable  by
disallowance  of submitted  claims,  civil  monetary and criminal  penalties and
exclusion from the Medicare and other federally financed programs.

                                       5
<PAGE>
 
         The laws of many states prohibit  physicians from sharing  professional
fees  with  non-physicians  and  prohibit  non-physician  entities,  such as the
Company,  from  practicing  medicine  (including  pathology)  and from employing
physicians to practice medicine (including pathology).  The Company believes its
current and planned  activities do not constitute  fee-splitting  or violate any
prohibition against the corporate practice of medicine. However, there can be no
assurance that future  interpretations  of such laws will not require structural
or organizational modifications of the Company's existing business.

COMPETITION

         The Company provides  services in a segment of the health care industry
that is highly  fragmented and extremely  competitive.  The Company's  actual or
potential  competitors  include large  university or teaching  hospitals;  large
clinical  laboratories that have  substantially  greater  financial,  marketing,
logistical  and  laboratory   resources  than  the  Company;   special   purpose
laboratories  that have limited test offerings and a highly focused  product and
marketing  strategy;  and the Company's customers or potential customers who may
choose to perform  services  similar to those  performed by the  Company.  It is
anticipated  that  competition  will continue to increase due to such factors as
the perceived  potential for commercial  applications of  biotechnology  and the
continued   availability  of  investment  capital  and  government  funding  for
cancer-related  research. There can be no assurance that competition in existing
or new  markets  will  not  have a  material  adverse  effect  on the  Company's
operating  results.  Changes in the regulatory  environment in which the Company
operates  could also affect the basis for  competition  and could thereby have a
material adverse effect on the Company's operating results.

ACCESS TO NEW TECHNOLOGIES; LACK OF PROPRIETARY TECHNOLOGY

         To date, the Company has not engaged in the development or patenting of
its own technologies for use in the analytical services it provides,  and access
to new technologies  developed by third parties has been an important element in
the Company's current business as well as the Company's long-term  strategy.  If
the Company's access to critical technologies were substantially diminished, the
Company's business could be adversely affected.

         In addition, the Company currently relies on certain technologies which
are not patentable or proprietary  and are therefore  available to the Company's
competitors.  Furthermore,  the  Company  relies on  certain  proprietary  trade
secrets and know-how,  which are not patentable.  Although the Company has taken
steps to protect its unpatented trade secrets and know-how,  principally through
the use of  confidentiality  agreements  with  its  employees,  there  can be no
assurance  that these  agreements  will not be breached,  that the Company would
have adequate  remedies for any breach or that the Company's  trade secrets will
not  otherwise  become  known or be  independently  developed or  discovered  by
competitors.  If the Company's  trade secrets become known or are  independently
developed or discovered by competitors,  it could have a material adverse effect
on the Company.

RISKS ASSOCIATED WITH DEVELOPMENT OF DATABASE

         The   confidentiality   of  patient   medical  records  is  subject  to
substantial  regulation by the state and federal governments.  State and federal
laws and  regulations  govern both the  disclosure  and the use of  confidential
patient medical record information.  Legislation governing the dissemination and
use of medical  record  information  is  continually  being proposed at both the
state and federal  levels.  For example,  the Health  Insurance  Portability and
Accountability  Act of 1996  requires  the U.S.  Secretary  of Health  and Human
Services to recommend legislation or to promulgate regulations governing privacy
standards  for  individually   identifiable   health   information.   Additional
legislation  may require that holders or users of  confidential  patient medical
information  implement measures to maintain the security of such information and
may regulate the dissemination of even anonymous patient information. Physicians
and other persons providing patient information to the Company are also required
to comply with these laws and regulations.  If a patient's  privacy is violated,
or if the Company is found to have violated any state or federal statute or

                                       6
<PAGE>
 
regulation with regard to the  confidentiality,  dissemination or use of patient
medical  information,  the Company could be liable for damages,  or for fines or
penalties.  The  Company  believes  that it is in material  compliance  with all
applicable state and federal laws and regulations governing the confidentiality,
dissemination and use of medical record  information.  However,  there can be no
assurance that differing interpretations of existing laws and regulations or the
adoption of new laws and regulations would not have a material adverse effect on
the ability of the Company to obtain or use patient  information which, in turn,
could have a  material  adverse  effect on the  Company's  plans to develop  and
market its cancer  information  database.  The  Company  intends to  continue to
monitor and review the  interpretation  and  enactment  of laws and  regulations
which impact the  Company's  plans to develop and market its cancer  information
database. In addition, the American Medical Association (the "AMA") has issued a
Current  Opinion to the effect that a physician  who does not obtain a patient's
consent to the disclosure of the patient's medical record  information  violates
the AMA's ethical standards.  While the AMA's Current Opinions are not law, they
may influence the  willingness  of physicians to obtain  patient  consents or to
disclose  patient  medical  information  to the  Company  and thus  could have a
material  adverse effect on the Company's plans to develop and market its cancer
information database.

RISKS ASSOCIATED WITH ESTABLISHING JOINT VENTURES

         The Company plans to pursue  strategic  partnerships and joint ventures
with  oncology   networks,   hospital   groups,   managed  care   companies  and
biopharmaceutical and large pharmaceutical companies, primarily for the purposes
of expanding IMPATH's diagnostic and prognostic  database,  participating in the
development of new cancer therapies and  demonstrating to the medical  community
the  importance  of the services  provided by IMPATH.  There can be no assurance
that the  Company  will be able to  negotiate  acceptable  partnership  or joint
venture  arrangements  or that  such  arrangements  will be  successful  or that
potential  partners will not pursue  alternative means of developing  treatments
for cancer.  No assurance can be given that the Company's joint venture partners
will be able to obtain regulatory approval for any new treatments, that any such
new treatments if so approved will be  commercialized  successfully  or that the
Company will realize any revenues in connection with such arrangements. Although
the Company  believes that other  parties to joint  ventures  generally  have an
economic  motivation  to  perform  their  contractual  responsibilities,   their
devotion of resources to such  activities  will not be within the control of the
Company.  Depending on the Company's  obligations  in such joint  ventures,  the
termination or cancellation of such arrangements could also adversely affect the
Company's  financial condition and results of operations.  In addition,  if such
joint  ventures  operate  outside of the United States or if the Company  enters
into a joint  venture with a foreign  partner,  the joint  venture's  operations
could be subject to the risks associated with foreign operations, including, but
not limited to, currency  fluctuations  and the  modification or introduction of
governmental policies with potentially adverse effects.

RISK OF LIABILITY; ADEQUACY OF INSURANCE COVERAGE

         The marketing and sale of health care services could expose the Company
to the risk of  certain  types of  litigation,  including  medical  malpractice.
Damages  assessed in  connection  with,  and the costs of  defending,  any legal
action  could be  substantial.  Although  the  Company is  presently  covered by
general  liability  insurance in the amount of $6.0 million per  occurrence  and
$7.0 million in the aggregate and has obtained professional  liability insurance
in the amount of $6.0 million per  occurrence  and $8.0 million in the aggregate
for the  Company's  Medical  Directors  and  other  physicians,  there can be no
assurance that insurance  coverage will provide  sufficient funds to satisfy any
judgments  which,  in the  future,  may be entered  against  the Company or that
liability  insurance in such amounts  will be  available  or  affordable  in the
future.  In  addition,  there  can be no  assurance  that all of the  activities
encompassed  within the  Company's  business  are  covered  under the  Company's
policies.  The  Company's  liability  insurance  covers  claims  relating to the
handling and disposal of medical  specimens and infectious and hazardous  waste,
except in the event of malfeasance or fraud by the Company.  Furthermore,  there
can be no assurance  that the Company will have other  resources  sufficient  to
satisfy any liability or litigation  expenses that may result from any uninsured
or  underinsured  claims.  Moreover,  although  the Company  maintains  personal
property

                                       7
<PAGE>
 
and  business  interruption  insurance  and has  taken  what it  believes  to be
adequate safeguards, the catastrophic loss of the Company's tissue library could
have a material adverse effect on the continued development of its database in a
manner which would not be fully compensated by insurance.

ANTI-TAKEOVER MEASURES

         The Company's  certificate of  incorporation  authorizes the Company to
issue  preferred  stock,  the  terms  of  which  may be  fixed  by the  Board of
Directors.  No  shares  of  preferred  stock  are  currently  outstanding.  Such
provisions  could have the effect of delaying,  deferring or preventing a change
of control of the Company.

POSSIBLE VOLATILITY OF STOCK PRICE

         There has been a history of significant volatility in the market prices
for shares of companies engaged in the health care and biotechnology fields, and
it may be expected  that the market price of the shares of Common Stock  offered
hereby may be highly  volatile.  Factors such as  fluctuations  in the Company's
quarterly  revenues  and  operating  results,   announcements  of  technological
innovations or new analytical  services by the Company or its  competitors,  and
changes in  third-party  reimbursement  and  governmental  regulation may have a
significant effect on the market price of the Common Stock.

DIVIDENDS

         The Company does not  currently  pay  dividends on its Common Stock and
does not  anticipate  paying any  dividends  in the  foreseeable  future.  It is
anticipated  that the terms of any  future  debt  financings  may  restrict  the
payment of dividends.

                                       8
<PAGE>
 
                             SELLING SECURITYHOLDERS

                  THE  FOLLOWING  TABLE SETS  FORTH  CERTAIN  INFORMATION  AS OF
JANUARY  31,  1998 (AND AS  ADJUSTED TO REFLECT THE SALE OF ALL OF THE SHARES OF
COMMON STOCK  OFFERED  HEREBY BY THE SELLING  STOCKHOLDERS)  WITH RESPECT TO THE
BENEFICIAL  OWNERSHIP  OF THE COMMON STOCK BY THE SELLING  STOCKHOLDERS.  ALL OF
SUCH SHARES OF COMMON STOCK ARE OWNED WITH SOLE VOTING AND INVESTMENT POWER.

<TABLE>
<CAPTION>


                                                                                      
                                                 
                                                    Beneficial Ownership                                  Beneficial Ownership
                                                    Prior to Offering(1)                                   After Offering(1)(2)
                                           -------------------------------------     Number of       --------------------------
                                                                 Percentage of       Shares of                        Percentage of
                           Title of          Number of          Shares of Class     Common Stock      Number of      Shares of Class

     Name                   Class             Shares             Outstanding(1)      to be Sold         Shares        Outstanding(1)

- -----------------       ------------       --------------     ------------------    ------------     -----------     --------------
<S>                     <C>                <C>                <C>                   <C>              <C>             <C>

Michael Abels and       Common Stock         20,000(3)                 *                20,000               0                    *
Jackeline Abels

</TABLE>

- ------------------

*         Less than one percent.

(1)       Includes  any  shares  that the named  person is  entitled  to receive
          within 60 days through the exercise of any option, warrant, conversion
          right or similar arrangement.

(2)       Assumes the sale of all shares of Common Stock offered hereby.

(3)       Consists  of 20,000  shares  which the named  persons  are is entitled
          jointly to receive  through  the  exercise  of  currently  exercisable
          warrants.

                                       9
<PAGE>
 
                              PLAN OF DISTRIBUTION

         The shares  offered hereby may be offered and sold from time to time by
the  Selling  Stockholders,   or  by  pledgees,  donees,  transferees  or  other
successors  in  interest.  Such  offers  and sales may be made from time to time
through the Nasdaq  National  Market or  otherwise,  at prices and on terms then
prevailing  or at  prices  related  to  the  then-current  market  price,  or in
negotiated  transactions.  The  methods  by  which  the  shares  may be sold may
include,  but are not limited to, the following:  (a) a block trade in which the
broker or dealer so  engaged  will  attempt  to sell the shares as agent but may
position  and  resell a portion  of the block as  principal  to  facilitate  the
transaction; (b) purchases by a broker or dealer as principal and resale by such
broker or dealer for its account;  (c) an exchange  distribution  in  accordance
with  the  rules of such  exchange;  (d)  ordinary  brokerage  transactions  and
transactions in which the broker solicits  purchasers;  (e) privately negotiated
transactions;  (f) short  sales;  and (g) a  combination  of any such methods of
sale. In effecting sales, brokers or dealers engaged by the Selling Stockholders
may receive  commissions or discounts from the Selling  Stockholders or from the
purchasers  in  amounts  to be  negotiated  immediately  prior to the sale.  The
Selling  Stockholders may also sell shares in accordance with Rule 144 under the
Securities Act.

         The Selling  Stockholders and any brokers and dealers  participating in
such  sales  may be  deemed  to be  "underwriters"  within  the  meaning  of the
Securities  Act.  There can be no assurance that the Selling  Stockholders  will
sell any or all of the shares offered hereby.

         The Company is bearing all of the costs relating to the registration of
the shares,  except  commissions,  discounts  or other fees payable to a broker,
dealer, underwriter, agent or market maker in connection with the sale of any of
the shares, all of which will be borne by the Selling Stockholders.  The Company
will not  receive any of the  proceeds  from the  Offering,  except that it will
receive $348,750 upon the exercise of the warrants.

         Pursuant   to  the   registration   rights   granted  to  the   Selling
Stockholders,  the Company has agreed to indemnify the Selling  Stockholders and
any person who controls a Selling  Stockholder  against certain  liabilities and
expenses  arising out of or based upon the information set forth or incorporated
by reference in this Prospectus,  and the  Registration  Statement of which this
Prospectus  is a part,  including  liabilities  under the  Securities  Act.  Any
commissions paid or any discounts or concessions allowed to any broker,  dealer,
underwriter, agent or market maker and, if any such broker, dealer, underwriter,
agent or market  maker  purchases  any of the shares as  principal,  any profits
received  on the  resale  of  such  shares,  may be  deemed  to be  underwriting
commissions or discounts under the Securities Act.

                                  LEGAL MATTERS

                  The validity of the  securities  being offered hereby is being
passed upon for the Company by Haythe & Curley,  237 Park Avenue,  New York, New
York 10017.


                                     EXPERTS

                  The consolidated financial statements of IMPATH Inc. as of 
December 31, 1996 and 1997, and for each of the years in the three-year period 
ended December 31, 1997, have been incorporated by reference herein and in the 
registration statement in reliance upon the report of KPMG Peat Marwick LLP, 
independent certified public accountants, incorporated by reference herein, and 
upon the authority of said firm as experts in accounting and auditing.

                                       10

<PAGE>
 
                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.

         The  following  are the  estimated  expenses  in  connection  with  the
distribution of the securities being registered hereunder.

                     S.E.C. registration fee*...............             $   202
                     Accounting fees and expenses...........               2,000
                     Legal fees and expenses................               2,500
                     Miscellaneous expenses.................               1,298
                                                                         -------


                                      Total.................             $ 6,000
                                                                         =======


- ----------------

*  Actual fee


ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Article  Five,  Section  7 of the  Certificate  of  Incorporation  (the
"Certificate")  provides that, to the fullest extent permitted by Section 145 of
the Delaware  General  Corporation  Law (the "Delaware  Law"), or any comparable
successor  law, as the same may be amended and  supplemented  from time to time,
the Company (i) may  indemnify all persons whom it shall have power to indemnify
under the Delaware Law from and against any and all of the expenses, liabilities
or other matters  referred to in or covered  thereby,  (ii) shall indemnify each
such person if he is or is threatened  to be made a party to an action,  suit or
proceeding by reason of the fact that he is or was a director, officer, employee
or agent of the Company or because he was serving the Company or any other legal
entity in any capacity at the request of the Company while a director,  officer,
employee  or agent of the  Company  and (iii)  shall pay the  expenses of such a
current or former  director,  officer,  employee or agent incurred in connection
with any such action,  suit or proceeding in advance of the final disposition of
such action,  suit or  proceeding.  The  Certificate  further  provides that the
indemnification  and  advancement of expenses  provided for therein shall not be
deemed exclusive of any other rights to which those entitled to  indemnification
or advancement of expenses may be entitled under any by-law, agreement, contract
or vote of stockholders or disinterested  directors or pursuant to the direction
(however embodied) of any court of competent jurisdiction or otherwise,  both as
to action in his official  capacity and as to action in another  capacity  while
holding  such office,  and shall  continue as to a person who has ceased to be a
director,  officer,  employee  or agent and shall  inure to the  benefit  of the
heirs, executors and administrators of such a person.

         The  Company  has  entered  into  indemnification  agreements  with all
directors and executive  officers of the Company.  These agreements provide that
the directors and executive officers will be indemnified to the fullest possible
extent  permitted  by Delaware law against all  expenses  (including  attorneys'
fees),  judgments,  fines,  penalties,  taxes  and  settlement  amounts  paid or
incurred by them in any action or proceeding,  including any action by or in the
right of the Company or any of its  subsidiaries  or  affiliates,  on account of
their service as directors,  officers,  employees,  fiduciaries or agents of the
Company  or any of its  subsidiaries  or  affiliates,  and their  service at the
request of the Company or any of its  subsidiaries  or  affiliates as directors,
officers, employees, fiduciaries or agents of another corporation,  partnership,
joint venture, trust, employee benefit plan or other enterprise.

                                      II-1
<PAGE>
 
         The  Company  maintains   liability  insurance  for  its  officers  and
directors,  insuring them against  certain losses arising from claims or charges
made against them while acting in their  capacities  as officers or directors of
the Company.

         Article Five, Section 6 of the Certificate  provides that a director of
the Company  shall not be personally  liable to the Company or its  stockholders
for  monetary  damages for breach of  fiduciary  duty as a director,  except for
liability (i) for any breach of the director's duty of loyalty to the Company or
its stockholders,  (ii) for acts or omissions not in good faith or which involve
intentional  misconduct  or a knowing  violation of law,  (iii) for the unlawful
payment of  dividends  or  unlawful  stock  purchases  under  Section 174 of the
Delaware Law, or (iv) for any  transaction  from which the director  derived any
improper personal  benefit.  If the Delaware Law is amended to eliminate further
or limit the personal  liability of directors,  then the liability of a director
of the Company shall be eliminated or limited to the fullest extent permitted by
the Delaware Law, as so amended. Any repeal or modification of such provision of
the Certificate by the stockholders of the Company shall be prospective only and
shall not adversely  affect any right or protection of a director of the Company
existing at the time of such repeal or modification.

         While the  Certificate  provides  directors with protection from awards
for monetary  damages for breaches of their duty of care,  it does not eliminate
such duty. Accordingly,  the Certificate will have no effect on the availability
of equitable  remedies such as an injunction or rescission based on a director's
breach of his or her duty of care. The provisions of the  Certificate  described
above apply to an officer of the Company  only if he or she is a director of the
Company and is acting in his or her  capacity as  director,  and do not apply to
officers of the Company who are not directors.

ITEM 16. EXHIBITS.

         The  Exhibits  required  to be  filed  as  part  of  this  Registration
Statement are listed in the attached Index to Exhibits.

ITEM 17. UNDERTAKINGS

         The  undersigned  Registrant  hereby  undertakes,  except as  otherwise
specifically  provided in the rules of the  Securities  and Exchange  Commission
promulgated under the Securities Act of 1933:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement;

          (i) To include  any  prospectus  required  by Section  10(a)(3) of the
Securities Act of 1933;


     (ii) To reflect in the  prospectus  any facts or events  arising  after the
effective date of this Registration Statement (or the most recent post-effective
amendment  hereof)  which,  individually  or  in  the  aggregate,   represent  a
fundamental change in the information set forth in this Registration  Statement;

     (iii) To  include  any  material  information  with  respect to the plan of
distribution  not  previously  disclosed in this  Registration  Statement or any
material change to such information in this  Registration  Statement;  provided,
however,  that paragraphs  (1)(i) and (1)(ii) do not apply if this  Registration
Statement is on Form S-3 or Form S-8 and the information required to be included
in a  post-effective  amendment  by those  paragraphs  is  contained in periodic
reports filed by the  Registrant  pursuant to Section 13 or Section 15(d) of the
Securities  Exchange  Act of 1934 that are  incorporated  by  reference  in this
Registration Statement;

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration  statement relating to the securities offered herein, and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof; and

                                      II-2
<PAGE>
 
         (3) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

         The  undersigned  registrant  hereby  undertakes  that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  Section  15(d)  of  the
Securities  Exchange  Act of 1934) that is  incorporated  by  reference  in this
Registration  Statement  shall  be  deemed  to be a new  registration  statement
relating to the securities  offered herein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 (the "Act") may be permitted to directors,  officers and controlling
persons of the  registrant  pursuant to the  provisions  of its  Certificate  of
Incorporation or By-laws or the laws of the State of Delaware, or otherwise, the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore,  unenforceable. In the event that a claim for indemnification
against such  liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.

                                      II-3
<PAGE>
 
                                POWER OF ATTORNEY

         The  registrant  and each person whose  signature  appears below hereby
appoints each of Anu D. Saad,  Ph.D.  and John P.  Gandolfo as  attorney-in-fact
with full power of substitution, severally, to execute in the name and on behalf
of the  registrant  and each such  person,  individually,  and in each  capacity
stated below, one or more amendments  (including  post-effective  amendments) to
this Registration  Statement (or any other  Registration  Statement for the same
offering that is to be effective  upon filing  pursuant to Rule 462(b) under the
Securities  Act of 1933) as the  attorney-in-fact  acting in the premises  deems
appropriate and to file the same with the Securities and Exchange Commission.

                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  City of New  York,  State of New  York,  on the 11th day of
March, 1998.

                           IMPATH INC.


                           By                  /s/ Anu D. Saad
                             ---------------------------------------------    
                                              Anu D. Saad, Ph.D.
                                    President and Chief Executive Officer

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Registration  Statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.


        Signature                       Title                        Date
        ---------                       -----                        ----

     /s/ Anu D. Saad          President, Chief Executive         March 11, 1998
 ----------------------       Officer and Director
   Anu D. Saad, Ph.D.         


 /s/ John P. Gandolfo         Executive Vice President,          March 11, 1998
- -----------------------       Chief Operating Officer,    
    John P. Gandolfo          Chief Financial Officer and 
                              Principal Accounting Officer
                                                           
                               

   /s/ John L. Cassis         Chairman of the Board and          March 11, 1998
   -------------------
     John L. Cassis           Director


/s/ Richard J. Cote, M.D.     Director                           March 11, 1998
- ------------------------
  Richard J. Cote, M.D.


   /s/ Richard Kessler        Director                           March 11, 1998
- ------------------------
     Richard Kessler

                                      II-4
<PAGE>
 
        Signature                         Title                      Date
        ---------                         -----                      ----



- -------------------------               Director               ________ __, 1998
 Joseph A. Mollica, Ph.D.


/s/Marcel Rozencweig, M.D.              Director                  March 11, 1998
- --------------------------
  Marcel Rozencweig, M.D.


- --------------------------              Director               ________ __, 1998
    David B. Snow, Jr.



 

                                      II-5
<PAGE>
 
                               INDEX TO EXHIBITS


Exhibit                                                               Sequential
Number                                   Document Description          Page No.
                                         --------------------         ----------

4         Warrant Certificate of IMPATH Inc. dated as of 
            February 14, 1997..................................
5         Opinion of Haythe & Curley...........................
23.1      Consent of KPMG Peat Marwick LLP.....................
23.2      Consent of Haythe & Curley (contained in Exhibit 5)
24        Power of Attorney (See signature page)


                                     

<PAGE>
 
                                                                       Exhibit 4





THIS  WARRANT  CERTIFICATE  AND THE  WARRANTS  EVIDENCED  HEREBY  HAVE  NOT BEEN
REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933 (THE "SECURITIES ACT")
BUT HAVE BEEN ISSUED PURSUANT TO AN EXEMPTION FROM SUCH REGISTRATION AND MAY NOT
BE SOLD,  TRANSFERRED,  PLEDGED,  HYPOTHECATED  OR  OTHERWISE  DISPOSED OF UNTIL
EITHER  (i) THE  HOLDER  THEREOF  SHALL  HAVE  RECEIVED  AN  OPINION  OF COUNSEL
REASONABLY  SATISFACTORY  TO THE COMPANY  THAT  REGISTRATION  THEREOF  UNDER THE
SECURITIES  ACT IS NOT  REQUIRED  OR (ii) A  REGISTRATION  STATEMENT  UNDER  THE
SECURITIES ACT WITH RESPECT THERETO SHALL HAVE BECOME EFFECTIVE.


No. W97-1                                                        20,000 Warrants



                               WARRANT CERTIFICATE

                  Warrants to subscribe for and purchase shares
                      of Common Stock, par value $.005, of

                                   IMPATH INC.



                  THIS  CERTIFIES  that, for value  received,  MICHAEL A. ABELS,
M.D. and JACKELINE ABELS, as joint tenants with rights of survivorship,  are the
owner and registered holder of the number of warrants (the "Warrants") set forth
above,  each of which entitles the owner thereof to purchase from IMPATH INC., a
Delaware  corporation (herein called the "Company"),  one share of Common Stock,
par  value  $.005,   of  the  Company   (individually,   a  "Common  Share"  and
collectively,  the "Common Shares"), at an exercise price of $17.4375 per share,
subject to adjustment  from time to time pursuant to the provisions of Section 2
(such price, as last adjusted,  being hereinafter  called the "Exercise Price").
The Warrants shall become  exercisable as to 556 Common Shares  beginning  March
14, 1997, shall become  exercisable as to an additional 556 Common Shares on the
14th day of each succeeding  month to and including  January 14, 2000, and shall
become  exercisable as to the balance of the Common Shares on February 14, 2000.
The  Warrants  shall  not be  exercisable  after  5:00 p.m.  (New York  Time) on
February 14, 2007.  For purposes of this Warrant  Certificate,  the term "Common
Shares" shall mean the class of capital stock of the Company  designated  common
stock,  par value $.005, as constituted on the date hereof,  and any other class
of  capital  stock  of  the  Company   resulting  from  successive   changes  or
reclassifications of the Common Shares.
<PAGE>
 
                  1. Exercise of Warrants.  The Warrants evidenced hereby may be
                     --------------------
exercised by the registered holder hereof, in whole or in part, by the surrender
of this Warrant Certificate,  duly endorsed (unless endorsement is waived by the
Company),  at the  principal  office of the Company (or at such other  office or
agency of the Company as it may designate by notice in writing to the registered
holder  hereof  at such  holder's  last  address  appearing  on the books of the
Company)  and upon  payment to the Company of the  Exercise  Price of the Common
Shares  purchased by certified or official  bank check or checks  payable to the
order of the  Company.  The Company  agrees that the Common  Shares so purchased
shall be  deemed to be issued  to the  registered  holder  hereof on the date on
which this Warrant  Certificate shall have been surrendered and payment made for
such Common Shares as aforesaid;  provided,  however, that no such surrender and
payment on any date when the stock transfer books of the Company shall be closed
shall be  effective  to  constitute  the person  entitled to receive such Common
Shares as the record holder thereof on such date, but such surrender and payment
shall be  effective  to  constitute  the person  entitled to receive such Common
Shares as the record  holder  thereof  for all  purposes  immediately  after the
opening of  business  on the next  succeeding  day on which such stock  transfer
books are open. The  certificate(s) for such Common Shares shall be delivered to
the registered  holder hereof within a reasonable  time, not exceeding ten days,
after Warrants  evidenced  hereby shall have been so exercised and a new Warrant
Certificate  evidencing the number of Warrants,  if any,  remaining  unexercised
shall also be issued to the  registered  holder  within  such time  unless  such
Warrants  shall have  expired.  No fractional  Common Shares of the Company,  or
scrips for any such fractional shares,  shall be issued upon the exercise of any
Warrants.

                  2.  Adjustment  in  Exercise  Price and Number of Shares.  The
                      ----------------------------------------------------
Board of Directors  of the Company  shall make such  adjustments,  if any, as it
deems  appropriate in the number of Common Shares  issuable upon exercise of the
Warrants or in the Exercise  Price,  or both,  as the Board of  Directors  shall
determine in good faith is  appropriate  in the event of any stock split,  stock
dividend, recapitalization,  merger, consolidation,  reorganization, combination
or exchange of shares or other similar event  affecting the corporate  structure
of the Company or the Common Shares occurring after the date hereof.

                  3.  Representations and Warranties of the Company. The Company
                      ---------------------------------------------
represents and warrants to and covenants  with the  registered  holder hereof as
follows:

                           (a)      The Company is a corporation duly organized,
validly  existing  and in good  standing  under  the laws of  Delaware,  is duly
qualified and in good standing under the laws of any foreign  jurisdiction where
the failure to be so qualified would
<PAGE>
 
have a material  adverse effect on its ability to perform its obligations  under
the Warrants evidenced by this Warrant  Certificate and has full corporate power
and  authority  to issue the  Warrants  and to carry out the  provisions  of the
Warrants evidenced by this Warrant Certificate.

                           (b)      The issuance, execution and delivery of this
Warrant  Certificate has been duly authorized by all necessary  corporate action
on the part of the Company and each of the  Warrants  evidenced  by this Warrant
Certificate constitutes the valid and legally binding obligation of the Company,
enforceable  against  it in  accordance  with the terms  hereof,  except as such
enforceability may be limited by bankruptcy,  insolvency or other laws affecting
generally the  enforceability  of creditors'  rights,  by general  principles of
equity and by limitations on the availability of equitable remedies.

                           (c)      Neither the execution and delivery of the
Warrants evidenced by this Warrant Certificate by the Company, nor compliance by
the  Company  with  the  provisions  hereof,   violates  any  provision  of  its
Certificate  of  Incorporation  or  By-Laws,  as amended,  or any law,  statute,
ordinance,  regulation,  order,  judgment or decree of any court or governmental
agency,  or  conflicts  with or will  result  in any  breach  of the terms of or
constitute a default  under or result in the  termination  of or the creation of
any lien  pursuant  to the terms of any  agreement  or  instrument  to which the
Company is a party or by which it or any of its properties is bound.

                  4. Company to Provide Stock. The Company  covenants and agrees
                     ------------------------
that all shares of capital  stock of the  Company  which may be issued  upon the
exercise  of the  Warrants  evidenced  hereby will be duly  authorized,  validly
issued  and fully  paid and  nonassessable  and free from all  taxes,  liens and
charges with respect to the issue thereof to the registered  holder hereof.  The
Company  further  covenants  and agrees that during the period  within which the
Warrants  evidenced  hereby  may be  exercised,  the  Company  will at all times
reserve  such number of shares of its capital  stock as shall be  sufficient  to
permit the exercise in full of the Warrants evidenced hereby.

                  5. Registered  Holder.  The registered  holder of this Warrant
                     ------------------
Certificate  shall be deemed  the owner  hereof  and of the  Warrants  evidenced
hereby for all purposes. The registered holder of this Warrant Certificate shall
not be entitled by virtue of ownership of this Warrant Certificate to any rights
whatsoever as a shareholder of the Company.

                  6.  Transfer.   This  Warrant  Certificate  and  the  Warrants
                      --------
evidenced  hereby  may  not  be  sold,  transferred,  pledged,  hypothecated  or
otherwise disposed of unless, in the opinion of
<PAGE>
 
counsel reasonably  satisfactory to the Company,  such transfer would not result
in a violation of the  provisions  of the United States  Securities  Act of 1933
(the  "Securities  Act").  Any  transfer  of this  Warrant  Certificate  and the
Warrants evidenced hereby, in whole or in part, shall be effected upon surrender
of this Warrant Certificate,  duly endorsed (unless endorsement is waived by the
Company),  at the  principal  office  or agency of the  Company  referred  to in
Section 1. If all of the Warrants evidenced hereby are being sold,  transferred,
pledged,  hypothecated  or otherwise  disposed of, the Company shall issue a new
Warrant Certificate registered in the name of the appropriate transferee(s).  If
less than all of the  Warrants  evidenced  hereby are being  sold,  transferred,
pledged,  hypothecated  or otherwise  disposed  of, the Company  shall issue new
Warrant  Certificates,  in each  case in the  appropriate  number  of  Warrants,
registered in the name of the registered holder hereof and the transferee(s), as
applicable. Any Common Shares of the Company issued upon any exercise hereof may
not be sold, transferred, pledged, hypothecated or otherwise disposed of unless,
in the opinion of counsel reasonably  satisfactory to the Company, such transfer
would not result in a violation of the Securities  Act. Each taker and holder of
this  Warrant  Certificate,  the  Warrants  evidenced  hereby  and any shares of
capital  stock of the Company  issued upon  exercise  of any such  Warrants,  by
taking or holding the same, consents to and agrees to be bound by the provisions
of this Section 6.

                  7. Expiration.  This Warrant Certificate, in all events, shall
                     ----------
be wholly void and have no effect after 5:00 P.M.
(New York Time) on February 14, 2007.

                  8.  Severability.  In  the  event  that  one  or  more  of the
                      ------------
provisions  of this  Warrant  Certificate  shall  for any  reason  be held to be
invalid, illegal or unenforceable in any respect, such invalidity, illegality or
unenforceability   shall  not  affect  any  other   provision  of  this  Warrant
Certificate, but this Warrant Certificate shall be construed as if such invalid,
illegal or unenforceable provision had never been contained herein.

                  9. Governing Law. This Warrant  Certificate  shall be governed
                     ------------- 
by and construed in accordance with the laws of the State of Delaware applicable
to agreements made and to be entirely performed within such State.
<PAGE>
 
                  IN WITNESS WHEREOF, IMPATH INC. has caused this Warrant
Certificate to be signed by a duly authorized officer and this
Warrant Certificate to be dated as of February 14, 1997.


                                   IMPATH INC.


                                   By     /s/ John P. Gandolfo
                                     ---------------------------------
                                            John P. Gandolfo
                                        Executive Vice President
<PAGE>
 
                                FORM OF EXERCISE
                                ----------------
 
                (to be executed by the registered holder hereof)


     The undersigned hereby exercises  __________  Warrants to subscribe for and
purchase shares of common stock,  par value $.005 ("Common  Shares"),  of IMPATH
INC.  evidenced by the within Warrant  Certificate and herewith makes payment of
the Exercise  Price for the Common  Shares.  Kindly issue  certificates  for the
Common Shares in accordance with the  instructions  given below. The certificate
for the  unexercised  balance,  if any, of the Warrants  evidenced by the within
Warrant Certificate will be registered in the name of the undersigned.

Dated:______________________________


                                 _______________________________________________
                                       Signature of Registered Holder


Instructions for registration of shares



_____________________________________
         Name (please print)


Social Security or Other Identifying
Number:______________________________


Address:


_____________________________________
             Street



_____________________________________
         City, State and Zip Code

<PAGE>
                                                                       Exhibit 5


                                                  March 13, 1998





IMPATH Inc.
521 West 57th Street
New York, New York  10019

Dear Sirs:

                  We  have  acted  as  counsel  for  IMPATH   Inc.,  a  Delaware
corporation  (the "Company"),  in connection with the registration  statement on
Form S-3 (the "Registration Statement"), filed by the Company on this date under
the  Securities  Act of 1933,  as amended,  with  respect to 20,000  shares (the
"Shares") of common stock, $.005 par value per share, of the Company held by the
Selling Stockholders named in the Registration Statement.

                  In  connection  with  the  Registration   Statement,  we  have
examined such records and documents and such  questions of law as we have deemed
necessary or appropriate for the purposes of this opinion.  On the basis of such
examination,  we advise you that in our  opinion  the Shares  have been duly and
validly authorized and issued and are fully paid and non-assessable.

                  We hereby  consent to the filing of this opinion as an exhibit
to the  Registration  Statement  and to the  reference  to us under the  caption
"Legal  Matters"  in the  prospectus  constituting  a part  of the  Registration
Statement.

                                                     Very truly yours,

<PAGE>
 
                                                                    EXHIBIT 23.1

                        Consent of Independent Auditors


The Board of Directors
IMPATH Inc.:

We consent to the use of our reports incorporated herein by reference.


                                                KPMG Peat Marwick LLP

Short Hills, New Jersey
March 11, 1998


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