PHARMACEUTICAL PRODUCT DEVELOPMENT INC
SC 13G, 2000-02-09
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                                          Page 1

SCHEDULE 13G

Name of Issuer:   Pharmaceutical Product Development, Inc.

Title of Class of Securities:       Common Stock

CUSIP Number:  717124101

(1)  Names of reporting Persons. S.S. or IRS. Identification Nos. of Above
     Persons. Fredric N. Eshelman

(2)  Check the Appropriate Box if a Member of a Group: NOT APPLICABLE (a)
                                                                      (b)

(3)  SEC Use Only:

(4)  Citizenship or Place of Organization: United States

     Number of Shares Beneficially Owned: (5) Sole Voting Power:  3,054,211

                                          (6) Shared Voting Power: 0

                                          (7) Sole Dispositive Power: 3,054,211

                                          (8) Shared Dispositive Power: 0

(9)  Aggregate Amount Beneficially Owned by Each Reporting Person: 3,054,211

(10) Check if the Aggregate amount in Row (9) Excludes Certain Shares: Not
     Applicable

(11) Percent of Class Represented by Amount in Row (9): 12.4%

(12) Type of Reporting Person: IN
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                                                                          Page 2

Item 1.   Issuer
          (a)      Pharmaceutical Product Development, Inc.
          (b)      3151 South 17th Street Extension
                   Wilmington, North Carolina  28412

Item 2.   Person Filing
          (a)      Fredric N. Eshelman
          (b)      Pharmaceutical Product Development, Inc.
                   3151 South 17th Street Extension
                   Wilmington, North Carolina 28412
          (c)      United States
          (d)      Common Stock
          (e)      717124101

Item 3.   Filing Pursuant to Rules 13d-1(b) or 13(d)-2(b)
          Not Applicable

Item 4.   Ownership
          (a)      3,054,211 includes 43,333 shares issuable pursuant to vested
                   options.
          (b)      12.4%
          (c)      The Reporting Person retains sole voting and dispositive
                   power of all shares.

Item 5.   Ownership of Five Percent or Less of  Class
          Not Applicable

Item 6.   Ownership of More than Five Percent on Behalf of Another Person
          Not Applicable

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on By the Parent Holding Company
          Not Applicable

Item 8.   Identification and Classification of Members of the Group
          Not Applicable

Item 9.   Notice of Dissolution of Group
          Not Applicable

Item 10.  Certification
          Not Applicable
<PAGE>

                                                                          Page 3

  After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

February 9, 2000
Date

Fredric N. Eshelman

/s/ Rudy C. Howard
Name:  Rudy C. Howard
Title:  Attorney in Fact*

* Signed pursuant to a power of attorney, dated December 16, 1998, included as
Exhibit A to Schedule 13G filed with the Securities and Exchange Commission by
Fredric N. Eshelman on February 9, 2000.
<PAGE>
                                    EXHIBIT A
                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that the undersigned hereby constitutes
and appoints each of Rudy C. Howard or Fred B. Davenport, Jr. signing singly,
with full power of substitution, his/her true and lawful attorney-in-fact, to
execute and cause to be filed and/or delivered, as required under Section 13(d)
of the Securities Exchange Act of 1934 (the "Act") and the regulations
thereunder, any number, as appropriate, of original, copies, or electronic
filings of the Securities and Exchange Commission Schedule 13G Beneficial
Ownership Reports (together with any amendments and joint filing agreements
under Rule 13-d-1(f) (1) of the Act, as may be required thereto) to be filed
and/or delivered with respect to any equity security (as defined in Rule
13(d)-1(d) under the Act) of Pharmaceutical Product Development, Inc.
beneficially owned by the undersigned and which must be reported by the
undersigned pursuant to Section 13(d) of the Act and the regulations thereunder,
and generally to take such other actions and perform such other things necessary
to effectuate the foregoing as fully in all respects as if the undersigned could
do if personally present.

         This Power of Attorney is governed by and shall be construed in
accordance with the laws of the State of North Carolina. This Power of Attorney
is effective until revoked by the undersigned, which revocation shall be
evidenced by an instrument in writing in form required by North Carolina law.
This Power of Attorney is executed pursuant to the provisions of the North
Carolina General Statutes, Chapter 32A, Article 2, with the intention that this
Power of Attorney and the authority of said attorney-in-fact hereunder shall
continue in effect notwithstanding any incapacity or mental incompetence which
may be incurred by the undersigned subsequent to the execution of this Power of
Attorney by the undersigned.

         IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 16th day of December, 1998.


                                                     /s/    Fredric N. Eshelman



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