<TABLE> <S> <C>
<ARTICLE> 6
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
ANNUAL REPORT OF AMERICAN CENTURY MUTUAL FUNDS, INC. AND IS QUALIFIED
IN ITS ENTIRETY BY REFERENCE TO SUCH REPORT.
</LEGEND>
<CIK> 0000100334
<NAME> AMERICAN CENTURY MUTUAL FUNDS, INC.
<SERIES>
<NUMBER> 22
<NAME> SELECT FUND - INSTITUTIONAL CLASS
<MULTIPLIER> 1000
<S> <C>
<PERIOD-TYPE> YEAR
<FISCAL-YEAR-END> OCT-31-2000
<PERIOD-END> OCT-31-2000
<INVESTMENTS-AT-COST> 5,112,720
<INVESTMENTS-AT-VALUE> 7,331,603
<RECEIVABLES> 140,125
<ASSETS-OTHER> 1,763
<OTHER-ITEMS-ASSETS> 0
<TOTAL-ASSETS> 7,473,491
<PAYABLE-FOR-SECURITIES> 99,651
<SENIOR-LONG-TERM-DEBT> 0
<OTHER-ITEMS-LIABILITIES> 6,158
<TOTAL-LIABILITIES> 105,809
<SENIOR-EQUITY> 49
<PAID-IN-CAPITAL-COMMON> 4,782,755
<SHARES-COMMON-STOCK> 4,948
<SHARES-COMMON-PRIOR> 3,139
<ACCUMULATED-NII-CURRENT> (853)
<OVERDISTRIBUTION-NII> 0
<ACCUMULATED-NET-GAINS> 368,030
<OVERDISTRIBUTION-GAINS> 0
<ACCUM-APPREC-OR-DEPREC> 2,225,310
<NET-ASSETS> 7,367,682
<DIVIDEND-INCOME> 60,148
<INTEREST-INCOME> 7,602
<OTHER-INCOME> 0
<EXPENSES-NET> 76,212
<NET-INVESTMENT-INCOME> (8,462)
<REALIZED-GAINS-CURRENT> 400,838
<APPREC-INCREASE-CURRENT> 170,802
<NET-CHANGE-FROM-OPS> 563,178
<EQUALIZATION> 0
<DISTRIBUTIONS-OF-INCOME> 0
<DISTRIBUTIONS-OF-GAINS> (12,251)
<DISTRIBUTIONS-OTHER> 0
<NUMBER-OF-SHARES-SOLD> 3,636
<NUMBER-OF-SHARES-REDEEMED> (1,029)
<SHARES-REINVESTED> 239
<NET-CHANGE-IN-ASSETS> 30,990
<ACCUMULATED-NII-PRIOR> 0
<ACCUMULATED-GAINS-PRIOR> 661,439
<OVERDISTRIB-NII-PRIOR> 0
<OVERDIST-NET-GAINS-PRIOR> 0
<GROSS-ADVISORY-FEES> 76,100
<INTEREST-EXPENSE> 0
<GROSS-EXPENSE> 76,212
<AVERAGE-NET-ASSETS> 197,126
<PER-SHARE-NAV-BEGIN> 53.41
<PER-SHARE-NII> 0.04
<PER-SHARE-GAIN-APPREC> 4.01
<PER-SHARE-DIVIDEND> 0.00
<PER-SHARE-DISTRIBUTIONS> (5.10)
<RETURNS-OF-CAPITAL> 0.00
<PER-SHARE-NAV-END> 52.36
<EXPENSE-RATIO> 0.80
</TABLE>
