UROGEN CORP
SC 13D, 2000-03-08
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13D
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                              (Amendment No. __)(1)

                                  Urogen Corp.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $.001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   917271108
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                               February 23, 2000
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)

      If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box |_|.

            Note. Schedules filed in paper format shall include a signed
      original and five copies of the schedule, including all exhibits. See Rule
      13d-7(b) for other parties to whom copies are to be sent.

                         (Continued on following pages)

                               (Page 1 of _ Pages)

- ----------
      (1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

      The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).
<PAGE>

CUSIP No. 917271108               SCHEDULE 13D                Page 2 of 14 Pages
- --------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Paramount Capital Asset Management, Inc.
- --------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
3     SEC USE ONLY


- --------------------------------------------------------------------------------
4     SOURCE OF FUNDS*

      OO (see Item 3 below)
- --------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
      TO ITEM 2(d) or 2(e)                                                   |_|

- --------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
- --------------------------------------------------------------------------------
                  7     SOLE VOTING POWER

                        None
                        --------------------------------------------------------
  NUMBER OF       8     SHARED VOTING POWER
   SHARES
BENEFICIALLY            5,169,831
  OWNED BY              --------------------------------------------------------
    EACH          9     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               None
    WITH                --------------------------------------------------------
                  10    SHARED DISPOSITIVE POWER

                        5,169,831
- --------------------------------------------------------------------------------
11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      5,169,831
- --------------------------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
      CERTAIN SHARES*                                                        |_|


- --------------------------------------------------------------------------------
13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      24.6%
- --------------------------------------------------------------------------------
14    TYPE OF REPORTING PERSON*

      CO
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

CUSIP No. 917271108               SCHEDULE 13D                Page 3 of 14 Pages
- --------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
3     SEC USE ONLY


- --------------------------------------------------------------------------------
4     SOURCE OF FUNDS*

      OO (see Item 3 below)
- --------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
      TO ITEM 2(d) or 2(e)                                                   |_|

- --------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
- --------------------------------------------------------------------------------
                  7     SOLE VOTING POWER

                        None
                        --------------------------------------------------------
  NUMBER OF       8     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,553,307
  OWNED BY              --------------------------------------------------------
    EACH          9     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               None
    WITH                --------------------------------------------------------
                  10    SHARED DISPOSITIVE POWER

                        1,553,307
- --------------------------------------------------------------------------------
11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,553,307
- --------------------------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
      CERTAIN SHARES*                                                        |_|


- --------------------------------------------------------------------------------
13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      7.5%
- --------------------------------------------------------------------------------
14    TYPE OF REPORTING PERSON*

      PN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

CUSIP No. 917271108               SCHEDULE 13D                Page 4 of 14 Pages
- --------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Aries Domestic Fund II, L.P.
- --------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
3     SEC USE ONLY


- --------------------------------------------------------------------------------
4     SOURCE OF FUNDS*

      OO (see Item 3 below)
- --------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
      TO ITEM 2(d) or 2(e)                                                   |_|

- --------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
- --------------------------------------------------------------------------------
                  7     SOLE VOTING POWER

                        None
                        --------------------------------------------------------
  NUMBER OF       8     SHARED VOTING POWER
   SHARES
BENEFICIALLY            249,535
  OWNED BY              --------------------------------------------------------
    EACH          9     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               None
    WITH                --------------------------------------------------------
                  10    SHARED DISPOSITIVE POWER

                        249,535
- --------------------------------------------------------------------------------
11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      249,535
- --------------------------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
      CERTAIN SHARES*                                                        |_|


- --------------------------------------------------------------------------------
13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      1.2%
- --------------------------------------------------------------------------------
14    TYPE OF REPORTING PERSON*

      PN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

CUSIP No. 917271108               SCHEDULE 13D                Page 5 of 14 Pages
- --------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      The Aries Master Fund, A Cayman Island Exempted Company
- --------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
3     SEC USE ONLY


- --------------------------------------------------------------------------------
4     SOURCE OF FUNDS*

      OO (see Item 3 below)
- --------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
      TO ITEM 2(d) or 2(e)                                                   |_|

- --------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      Cayman Islands
- --------------------------------------------------------------------------------
                  7     SOLE VOTING POWER

                        None
                        --------------------------------------------------------
  NUMBER OF       8     SHARED VOTING POWER
   SHARES
BENEFICIALLY            3,366,989
  OWNED BY              --------------------------------------------------------
    EACH          9     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               None
    WITH                --------------------------------------------------------
                  10    SHARED DISPOSITIVE POWER

                        3,366,989
- --------------------------------------------------------------------------------
11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      3,366,989
- --------------------------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
      CERTAIN SHARES*                                                        |_|


- --------------------------------------------------------------------------------
13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      24.6%
- -------------------------------------------------------------------------------
14    TYPE OF REPORTING PERSON*

      OO (see Item 2)
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

CUSIP No. 917271108               SCHEDULE 13D                Page 6 of 14 Pages
- --------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |_|
- --------------------------------------------------------------------------------
3     SEC USE ONLY


- --------------------------------------------------------------------------------
4     SOURCE OF FUNDS*

      OO (see Item 3 below)
- --------------------------------------------------------------------------------
5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT
      TO ITEM 2(d) or 2(e)                                                   |_|

- --------------------------------------------------------------------------------
6     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
- --------------------------------------------------------------------------------
                  7     SOLE VOTING POWER

                        124,338
                        --------------------------------------------------------
  NUMBER OF       8     SHARED VOTING POWER
   SHARES
BENEFICIALLY            5,169,831
  OWNED BY              --------------------------------------------------------
    EACH          9     SOLE DISPOSITIVE POWER
  REPORTING
   PERSON               124,338
    WITH                --------------------------------------------------------
                  10    SHARED DISPOSITIVE POWER

                        5,169,831
- --------------------------------------------------------------------------------
11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      5,294,169
- --------------------------------------------------------------------------------
12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
      CERTAIN SHARES*                                                        |_|


- --------------------------------------------------------------------------------
13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

      25.2%
- --------------------------------------------------------------------------------
14    TYPE OF REPORTING PERSON*

      IN
- --------------------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>

Item 1. Security and Issuer.

      (a)   Common Stock, $.001 par value ("Shares")

            Urogen Corp. (the "Issuer")
            10835 Altman Rd., Suite 950
            San Diego, CA 92121
            (619) 450-5949

Item 2. Identity and Background.

      Names of Persons Filing:

      (a)   This statement is filed on behalf of Paramount Capital Asset Man
            agement, Inc. ("Paramount Capital"), Aries Domestic Fund, L.P.
            ("Aries Domestic"), Aries Domestic Fund II, L.P. ("Aries II"), Aries
            Master Fund, a Cayman Island exempted company ("Aries Fund") and
            Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald" and collec tively,
            "Reporting Parties"). See attached Exhibit A which is a copy of
            their agreement in writing to file this statement on behalf of each
            of them.

      (b)   Paramount Capital's, Aries Domestic's, Aries II's and Dr.
            Rosenwald's business address is 787 Seventh Avenue, 48th Floor, New
            York, New York, 10019. The business address for Aries Fund is c/o
            MeesPierson (Cayman) Limited, P.O. Box 2003, British American
            Centre, Phase 3, Dr. Roy's Drive, George Town, Grand Cayman.

      (c)   Dr. Rosenwald is an investment banker, venture capitalist, fund
            manager and sole shareholder of Paramount Capital,(1) a Subchapter S
            corporation incorporated in Delaware. Paramount Capital is the
            General Partner of Aries Domestic,(2) a limited partnership incorpo
            rated in Delaware. Paramount Capital is the Investment Manager to
            Aries Fund,(3) a Cayman Islands exempted company.

      (d)   Dr. Rosenwald, Paramount Capital, Aries Domestic, Aries II and Aries
            Fund and their respective officers, directors, general partners,
            investment managers, or trustees have not, during the five years
            prior to the date hereof, been convicted in a criminal proceeding
            (excluding traffic violations or similar misdemeanors).

      (e)   Dr. Rosenwald, Paramount Capital, Aries Domestic, Aries II and Aries
            Fund and their respective officers, directors, general partners,
            investment managers, or trustees have not been, during the five
            years prior to the date hereof, parties to a civil proceeding of a
            judicial or administrative body of competent jurisdiction, as a
            result of which such person was or is subject to a judgment, decree
            or final order enjoining future violations of, or prohibiting or
            mandating activities subject to, Federal or State securities laws or
            finding any violation with respect to such laws.

      (f)   Dr. Rosenwald is a citizen of the United States.

- ----------

     (1)    Please see attached Exhibit B indicating the executive officers and
            directors of Paramount Capital and providing information called for
            by Items 2-6 of this statement as to said officers and directors.
            Exhibit B is herein incorporated by reference.

     (2)    Please see attached Exhibit C indicating the general partner of
            Aries Domestic and Aries II and the general partner's executive
            officers and directors and providing information called for by Items
            2-6 of this statement as to said general partners, officers and
            directors. Exhibit C is herein incorporated by reference.

     (3)    Please see attached Exhibit D indicating the investment manager of
            the Aries Fund and the investment manager's executive officers and
            directors and providing information called for by Items 2-6 of this
            statement as to said investment manager and officers and directors.
            Exhibit D is herein incorporated by reference.


                                       7
<PAGE>

Item 3. Source and Amount of Funds or Other Consideration.

      On February 23, 2000, in a private placement of the Issuer's securities,
      Aries Domestic used $5,181,991 of its general funds to purchase 609,646
      Shares, Aries II used $873,579 of its general funds to purchase 102,774
      Shares and the Aries Fund used $10,944,930 of its general funds to
      purchase 1,287,580 Shares. On January 13, 2000, in a private offering by
      the Issuer, Aries Domestic used $867,052 of its general funds to purchase
      433,526 Shares, Aries II used $134,848 of its general funds to purchase
      67,424 Shares, the Aries Fund used $1,910,600 of its general funds to
      purchase 955,300 Shares and Dr. Rosenwald used $50,000 of personal funds
      to purchase 25,000 Shares. In addition, on January 13, 2000, in a separate
      private offering by the Issuer, Aries Domestic used $256,767.95 of its
      general funds to purchase 340,090 Shares and warrants to purchase 170,045
      Shares at an exercise price equal to $0.75 per Share (the "Warrants"),
      Aries II used $39,933.46 of its general funds to purchase 52,892 Shares
      and 26,446 Warrants, the Aries Fund used $565,801.53 of its general funds
      to purchase 749,406 Shares and 374,703 Warrants and Dr. Rosenwald used his
      $49,999,12 of personal funds to purchase 66,224 Shares and 33,112
      Warrants.

Item 4. Purpose of Transaction.

      The Reporting Parties acquired shares of Common Stock of the Issuer as an
      investment in the Issuer.

      Although the Reporting Parties have not formulated any definitive plans,
      they may from time to time acquire, or dispose of, Common Stock and/or
      other securities of the Issuer if and when they deem it appropriate. The
      Reporting Parties may formulate other purposes, plans or proposals
      relating to any of such securities of the Issuer to the extent deemed
      advisable in light of market conditions, investment policies and other
      factors.

      Except as indicated in this Schedule 13D, the Reporting Parties currently
      have no plans or proposals that relate to or would result in any of the
      matters described in subparagraphs (a) through (j) of Item 4 of Schedule
      13D.

Item 5. Interest in Securities of the Issuer.

      (a)   As of March 2, 2000, Dr. Rosenwald, both personally and through
            acquisition of the shares by the Aries Fund, Aries Domestic and
            Aries II, beneficially owned 5,294,169 Shares or 25.2% of the
            Issuer's securities and Paramount Capital beneficially owned
            5,169,831 Shares or 24.6% of the Issuer's securities. Aries Domestic
            and the Aries Fund beneficially owned as follows:

                                              Amount Owned
                                              ------------
            Aries Domestic                  1,553,307 Shares
            Aries II                          249,535 Shares
            Aries Fund                      3,366,989 Shares

      (b)   Dr. Rosenwald and Paramount Capital share the power to vote or to
            direct the vote, to dispose or to direct the disposition of those
            shares owned by each of Aries Domestic, Aries II and Aries Fund.

      (c)   Acquisitions made by the Reporting Parties within the past 60 days
            are as set forth in Item 3.

            Other than as set forth herein the Reporting Parties have not
            engaged in any transactions in the Common Stock of the Issuer during
            the past 60 days.

      (d) & (e) Not applicable.

Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
        Securities of the Issuer:

      Paramount Capital is the Investment Manager of the Aries Fund and the
      General Partner of each of Aries Domestic and Aries II and in such
      capacities has the authority to make certain investment decisions on
      behalf of such entities, including decisions relating to the securities of
      the Issuer. In connection with its investment management duties,


                                       8
<PAGE>

      Paramount Capital receives certain management fees and performance
      allocations from the Aries Fund, Aries Domestic and Aries II. Dr.
      Rosenwald is the Chairman and sole stockholder of Paramount Capital.

      Except as indicated in this 13D and exhibits, there is no contract,
      arrangement, understanding or relationship between the Reporting Parties
      and any other person, with respect to any securities of the Issuer.

Item 7. Material to be Filed as Exhibits:

Exhibit A - Copy of an Agreement between Dr. Rosenwald, Paramount Capital,
            Aries Domestic and Aries Fund to file this Statement on Schedule 13D
            on behalf of each of them.

Exhibit B - List of executive officers and directors of Paramount Capital
            and information called for by Items 2-6 of this statement relating
            to said officers and directors.

Exhibit C - List of executive officers and directors of Aries Domestic and
            Aries II and information called for by Items 2-6 of this statement
            relating to said officers and directors.

Exhibit D - List of executive officers and directors of Aries Fund and
            information called for by Items 2-6 of this statement relating to
            said officers and directors.


                                       9
<PAGE>

                                   SIGNATURES


            After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.

                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND II, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                THE ARIES FUND
                                By: Paramount Capital Asset Management, Inc.
                                    Investment Manager


Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.


                                       10



                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D

            The undersigned hereby agrees to jointly prepare and file with
regulatory authorities a Schedule 13D and any future amendments thereto
reporting each of the undersigned's ownership of securities of Urogen Corp., and
hereby affirm that such Schedule 13D is being filed on behalf of each of the
undersigned.

                                PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                ARIES DOMESTIC FUND II, L.P.
                                By: Paramount Capital Asset Management, Inc.
                                    General Partner

Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


                                THE ARIES FUND
                                By: Paramount Capital Asset Management, Inc.
                                    Investment Manager


Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.
                                   Chairman


Dated:   March 2, 2000
         New York, NY           By /s/ Lindsay A. Rosenwald, M.D.
                                   ---------------------------------------------
                                   Lindsay A. Rosenwald, M.D.


                                       11



                                    EXHIBIT B

      The name and principal occupation or employment, which in each instance is
with Paramount Capital Asset Management, Inc. ("Paramount Capital") located at
787 Seventh Avenue, 48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                       PRINCIPAL OCCUPATION
         NAME                              OR EMPLOYMENT
         ----                              -------------

Lindsay A. Rosenwald, M.D.    Chairman of the Board of Paramount Capital
                              Asset Management, Inc., Paramount Capital
                              Investments, LLC and Paramount Capital, Inc.

Mark C. Rogers, M.D.          President of Paramount Capital Asset
                              Management, Inc., Paramount Capital
                              Investments, LLC and Paramount Capital, Inc.

Peter Morgan Kash             Director of Paramount Capital Asset
                              Management, Inc., Senior Man aging Director,
                              Paramount Capital, Inc.

Dr. Yuichi Iwaki              Director of Paramount Capital Asset
                              Management, Inc., Professor, Uni versity of
                              Southern California School of Medicine

Item 2.

      During the five years prior to the date hereof, none of the above persons
(to the best of Paramount Capital's knowledge) was convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a civil proceeding of a judicial or administrative body of competent
jurisdiction, as a result of which such person was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       12



                                    EXHIBIT C

      The name and principal occupation or employment, which is located at 787
Seventh Avenue, 48th Floor, New York, New York, 10019, of the General Partner of
Aries Domestic and Aries II is as follows:

                                       PRINCIPAL OCCUPATION
         NAME                              OR EMPLOYMENT
         ----                              -------------

Paramount Capital Asset
 Management, Inc.                General Partner; Investment Manager


      Exhibit B is hereby incorporated by reference.

Item 2.

      During the five years prior to the date hereof, the above person (to the
best of Aries Domestic's knowledge) has not been convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a civil proceeding of a judicial or administrative body of competent
jurisdiction, as a result of which such person was or is subject to a judgment,
decree or final order enjoining future violations of, or prohibiting or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       13



                                    EXHIBIT D

      The name and principal occupation or employment, which in each instance is
with The Aries Master Fund ("Aries Fund") located at c/o MeesPierson (Cayman)
Limited, P.O. Box 2003, British American Centre, Phase 3, Dr. Roy's Drive,
George Town, Grand Cayman, of each executive officer and director of Aries Trust
is as follows:

                                                    PRINCIPAL OCCUPATION
               NAME                                     OR EMPLOYMENT
               ----                                     -------------

Paramount Capital Asset Management, Inc.              Investment Manager

MeesPierson (Cayman) Management Limited               Administrator

      Exhibit B is hereby incorporated by reference.

Item 2.

      During the five years prior to the date hereof, neither of the above
persons (to the best of Aries Fund's knowledge) have been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors) or
was a party to a civil proceeding of a judicial or administrative body of
competent jurisdiction, as a result of which such person was or is subject to a
judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

      Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       14


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