CONNETICS CORP
S-8 POS, 1997-06-30
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
      As filed with the Securities and Exchange Commission on June 30, 1997
                                                      Registration No. 333-04985
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                ----------------

                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------

                             CONNECTICS CORPORATION
             (Exact name of Registrant as specified in its charter)

         DELAWARE                                        94-3173928
(State of incorporation)                    (I.R.S. Employer Identification No.)

                             3400 WEST BAYSHORE ROAD
                               PALO ALTO, CA 94303
                    (Address of principal executive offices)

                             -----------------------

                        1995 EMPLOYEE STOCK PURCHASE PLAN
                                 1994 STOCK PLAN
                        1995 DIRECTORS' STOCK OPTION PLAN

                             -----------------------

                                THOMAS G. WIGGANS
                       PRESIDENT & CHIEF EXECUTIVE OFFICER
                             CONNECTICS CORPORATION
                             3400 WEST BAYSHORE ROAD
                               PALO ALTO, CA 94303
                                 (415) 843-2800
 (Name, address and telephone number, including area code, of agent for service)

                             -----------------------

                                    Copy to:

                                 JOSHUA L. GREEN
                                Venture Law Group
                               2800 Sand Hill Road
                          Menlo Park, California 94025
                                 (415) 854-4488

                               Page 1 of 53 Pages
                             Exhibit Index on Page 7
               (Calculation of Registration Fee on following page)


<PAGE>   2
<TABLE>
<CAPTION>

                                           CALCULATION OF REGISTRATION FEE
======================================================================================================================
                                                                   Proposed Maximum      Proposed
                                                Maximum Amount      Offering Price        Maximum        Amount of
                                                     to be            Per Share          Aggregate      Registration
    Title of Securities to be Registered         Registered(1)                        Offering Price        Fee
- ----------------------------------------------------------------------------------------------------------------------
<S>                                              <C>                   <C>               <C>              <C>   
NON-PLAN OPTIONS
   Common Stock Issuable upon Exercise of
   Outstanding Options,
   $0.001 par value                        .     13,488 Shares         $0.45(2)          $  6,069.60      $ 1.84
                                                 30,000 Shares         $7.125(2)         $213,750.00      $64.77

1994 STOCK PLAN
   Common Stock Issuable upon Exercise of
   Outstanding Options,                         500,000 Shares         $7.00(3)          $3,500,000       $1,060.61
   $0.001 par value                        .

                  TOTAL                         543,488 Shares                                            $1,127.22
======================================================================================================================
</TABLE>

- -----------------------
(1)      This Registration Statement shall also cover any additional shares of
         Common Stock which become issuable under any of the referenced plans
         being registered pursuant to this Registration Statement by reason of
         any stock dividend, stock split, recapitalization or any other similar
         transaction effected without the receipt of consideration, which
         results in an increase in the number of the Registrant's outstanding
         shares of Common Stock.

(2)      Computed in accordance with Rule 457(h) under the Securities Act solely
         for the purpose of calculating the registration fee. Computation based
         on the per share exercise price (rounded to nearest cent) at which the
         options under the referenced plans may be exercised.

(3)      Estimated in accordance with Rule 457(c) under the Securities Act of
         1933, as amended (the "Securities Act") solely for the purpose of
         calculating the registration fee. The computation is based upon the
         average of the bid and ask sale prices of the Common Stock as reported
         on the Nasdaq National Market on June 25, 1997.





                                      -2-
<PAGE>   3
                                     PART I
              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

THE ENTIRE CONTENTS OF THE COMPANY'S REGISTRATION STATEMENT ON FORM S-8 (FILE
NO. 333-04985) ARE INCORPORATED BY REFERENCE INTO THIS REGISTRATION STATEMENT.


                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3.           INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following documents filed with the Securities and Exchange
Commission (the "Commission") are incorporated by reference into this
Registration Statement:

         a. The description of the Company's Common Stock set forth in the
Company's Registration Statement on Form 8-A filed with the Commission on
December 8, 1995, including any amendment thereto or report filed for the
purpose of updating such description (File No. 0-27406).

         b. The description of the Company's Preferred Share Purchase Rights set
forth in the Company's Registration Statement on Form 8-A filed with the
Commission on May 23, 1997, including any amendment thereto or report filed for
the purpose of updating such description (File No. 0-27406).

         c. The Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1996 (File No. 0-27406), and all amendments thereto filed March 20,
1997 (including each of the Annual Reports on Form 10-K/A filed April 14, 1997
and April 28, 1997).

         d. The Company's Registration Statement on Form S-8, effective May 31,
1996 (File No. 333-04985).

         e. The Company's Quarterly Report on Form 10-Q filed May 15, 1997 (File
No. 0-27406).

         f. The Company's Current Report on form 8-K/A filed April 28, 1997
(File No. 0-27406).

         g. The Company's Current Report on Form 8-K filed May 23, 1997 (File
No. 0-27406).

         h. The Company's Current Report on Form 8-K filed June 6, 1997 (File
No. 0-27406).

         All documents subsequently filed by the Registrant pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have
been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference into this Registration Statement and to
be part hereof from the date of filing such documents. Any statement contained
in a document incorporated by reference herein shall be deemed to be modified or
superseded for purposes hereof to the extent that a statement contained herein
(or in any other subsequently filed document which also is incorporated by
reference herein) modifies or supersedes such statement. Any such statement so
modified or superseded shall not be deemed to constitute a part hereof, except
as so modified or superseded.

<TABLE>
<CAPTION>
Item 8.           EXHIBITS.

                     Exhibit
                     Number
                     --------
                     <S>         <C>
                     4.3         1994 Stock Plan, as amended.
                     4.4         1995 Employee Stock Purchase Plan, as amended.
                     4.5         1995 Directors' Stock Option Plan.
                     4.6         Form of Stock Option Agreement (substantially identical agreements for Arthur
                                 Eisen, Phillip Hanawalt, Gerald Nepom and G. Kirk Raab), with schedule.
                     4.7         Form of Notice of Stock Option Grant for Arthur Eisen.
                     4.8         Form of Notice of Stock Option Grant for Phillip Hanawalt.
                     4.9         Form of Notice of Stock Option Grant for Gerald Nepom.
                     4.10        Form of Notice of Stock Option Grant for G. Kirk Raab.
                     5.1         Opinion of Venture Law Group, a Professional Corporation.
</TABLE>




                                      -3-
<PAGE>   4

<TABLE>
<CAPTION>
                     <S>         <C>
                     23.1        Consent of Venture Law Group, a Professional Corporation (included in Exhibit
                                 5.1).
                     23.2        Consent of Ernst & Young LLP, Independent Auditors.
                     24.1        Power of Attorney.
</TABLE>







                                      -4-
<PAGE>   5
                                   SIGNATURES


         Pursuant to the requirements of the Securities Act of 1933, the
Registrant, Connectics Corporation (formerly, Connective Therapeutics, Inc.), a
corporation organized and existing under the laws of the State of Delaware,
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Palo Alto, State of California, on June 30, 1997.

                                             CONNECTICS CORPORATION


                               By:  /s/ Cynthia M. Butitta
                                  ----------------------------------------------
                                  Cynthia M. Butitta
                                  Vice President of Finance and Administration
                                  and Chief Financial Officer







                                      -5-
<PAGE>   6
                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons in the
capacities and on June 30, 1997.


<TABLE>
<CAPTION>
              Signature                                                    Title
              ---------                                                    -----


<S>                                     <C>
/s/ Thomas G. Wiggans*                  President, Chief Executive Officer and Director (Principal Executive
- --------------------------------          Officer)
Thomas G. Wiggans


/s/ Cynthia M. Butitta*                 Vice President of Finance and Administration and Chief Financial Officer
- --------------------------------          (Principal Financial and Accounting Officer)
Cynthia M. Butitta                        


/s/ G. Kirk Raab*
- --------------------------------        Chairman of the Board
G. Kirk Raab


/s/ Alexander E. Barkas, Ph.D.*         Director
- --------------------------------
Alexander E. Barkas, Ph.D.


/s/ Eugene A. Bauer, M.D.*              Director
- --------------------------------
Eugene A. Bauer, M.D.


/s/ Brian H. Dovey*                     Director
- --------------------------------
Brian H. Dovey


- --------------------------------        Director
John C. Kane


/s/ Thomas D. Kiley*                    Director
- --------------------------------
Thomas D. Kiley


- --------------------------------        Director
Kenneth B. Plumlee


/s/ Joseph J. Ruvane, Jr.*              Director
- --------------------------------
Joseph J. Ruvane, Jr.


*By  /s/ Cynthia M. Butitta
- --------------------------------
         Cynthia M. Butitta
         Attorney-in-fact
</TABLE>






                                      -6-
<PAGE>   7
                                INDEX TO EXHIBITS



<TABLE>
<CAPTION>
  Exhibit                                                                                              Page
   Number                                                                                                No.
   ------                                                                                              -----
    <S>       <C>                                                                                       <C>
     4.3      1994 Stock Plan, as amended.                                                               8
     4.4      1995 Employee Stock Purchase Plan, as amended.                                            19
     4.5      1995 Directors' Stock Option Plan.                                                         *
     4.6      Form of Stock Option Agreement (substantially identical agreements for Arthur             32
              Eisen, Phillip Hanawalt, Gerald Nepom and G. Kirk Raab), with schedule.
     4.7      Notice of Stock Option Grant for Arthur Eisen.                                            45
     4.8      Notice of Stock Option Grant for Phillip Hanawalt.                                        46
     4.9      Notice of Stock Option Grant for Gerald Nepom.                                            47
     4.10     Notice of Stock Option Grant for G. Kirk Raab.                                            48
     5.1      Opinion of Venture Law Group, a Professional Corporation.                                 49
    23.1      Consent of Venture Law Group, a Professional Corporation (included in Exhibit 5.1).       49
    23.2      Consent of Ernst & Young LLP, Independent Auditors.                                       50
    24.1      Power of Attorney.                                                                         *
</TABLE>

- ------------------------
* Previously filed with the Company's Registration Statement on Form S-8
  (333-04985)





                                      -7-

<PAGE>   1
                                                                     EXHIBIT 4.3



                          CONNECTIVE THERAPEUTICS, INC.

                                 1994 STOCK PLAN
                        (AS AMENDED THROUGH MAY 14, 1997)


         1. Purposes of the Plan. The purposes of this Stock Plan are to attract
and retain the best available personnel for positions of substantial
responsibility, to provide additional incentive to Employees and Consultants of
the Company and its Subsidiaries and to promote the success of the Company's
business. Options granted under the Plan may be Incentive Stock Options (as
defined under Section 422 of the Code) or Nonstatutory Stock Options, as
determined by the Administrator at the time of grant of an option and reflected
in the terms of the written option agreement. Stock purchase rights may also be
granted under the Plan.

         2. Definitions. As used herein, the following definitions shall apply:

            (a) "Administrator" means the Board or any of its Committees
appointed pursuant to Section 4 of the Plan.

            (b) "Board" means the Board of Directors of the Company.

            (c) "Code" means the Internal Revenue Code of 1986, as amended.

            (d) "Committee" means the Committee appointed by the Board of
Directors in accordance with Section 4(a) of the Plan below, if one is
appointed.

            (e) "Common Stock" means the Common Stock of the Company.

            (f) "Company" means Connective Therapeutics, Inc., a Delaware
corporation.

            (g) "Consultant" means any person, including an advisor, who is
engaged by the Company or any Parent or Subsidiary to render services and is
compensated for such services, and any director of the Company, whether
compensated for such services or not.

            (h) "Continuous Status as an Employee or Consultant" means the
absence of any interruption or termination of service as an Employee or
Consultant. Continuous Status as an Employee or Consultant shall not be
considered interrupted in the case of sick leave, military leave, or any other
leave of absence approved by the Administrator, provided that such leave is for
a period of not more than ninety (90) days, unless reemployment upon the
expiration of such leave is guaranteed by contract or statute, or unless
provided otherwise pursuant to Company policy adopted from time to time, or in
the case of transfers between locations of the Company or between the Company,
its Subsidiaries or its successor. For purposes of this Plan, a change in status
from an Employee to a Consultant or from a Consultant to an Employee will not
constitute a termination of employment.

            (i) "Director" means a member of the Board.

            (j) "Employee" means any person, including Named Executives,
Officers and Directors, employed by the Company or any Parent or Subsidiary of
the Company. The payment by the Company of a director's fee to a Director shall
not be sufficient to constitute "employment" of such Director by the Company.

            (k) "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

            (l) "Fair Market Value" means, as of any date, the value of Common
Stock determined as follows:



                                      -8-
<PAGE>   2
                (i) If the Common Stock is listed on any established stock
exchange or a national market system including without limitation the National
Market of the National Association of Securities Dealers, Inc. Automated
Quotation ("Nasdaq") System, its Fair Market Value shall be the closing sales
price for such stock as quoted on such system on the date of determination (or
the closing bid, if no sales were reported on that day) as reported in The Wall
Street Journal or such other source as the Administrator deems reliable;

                (ii) If the Common Stock is quoted on the Nasdaq System (but not
on the National Market thereof) or regularly quoted by a recognized securities
dealer but selling prices are not reported, its Fair Market Value shall be the
mean between the high bid and low asked prices for the Common Stock or;

                (iii) In the absence of an established market for the Common
Stock, the Fair Market Value thereof shall be determined in good faith by the
Administrator.

             (m) "Incentive Stock Option" means an Option intended to qualify as
an incentive stock option within the meaning of Section 422 of the Code, as
designated in the applicable written option agreement.

             (n) "Named Executive" means any individual who, on the last day of
the Company's fiscal year, is the chief executive officer of the Company (or is
acting in such capacity) or among the four highest compensated officers of the
Company (other than the chief executive officer). Such officer status shall be
determined pursuant to the executive compensation disclosure rules under the
Exchange Act.

             (o) "Nonstatutory Stock Option" means an Option not intended to
qualify as an Incentive Stock Option, as designated in the applicable written
option agreement.

             (p) "Officer" means a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.

             (q) "Option" means a stock option granted pursuant to the Plan.

             (r) "Optioned Stock" means the Common Stock subject to an Option or
a Stock Purchase Right.

             (s) "Optionee" means an Employee or Consultant who receives an
Option or Stock Purchase Right.

             (t) "Parent" means a "parent corporation", whether now or hereafter
existing, as defined in Section 424(e) of the Code.

             (u) "Plan" means this 1994 Stock Plan.

             (v) "Restricted Stock" means shares of Common Stock acquired
pursuant to a grant of a Stock Purchase Right under Section 11 below.

             (w) "Rule 16b-3" means Rule 16b-3 promulgated under the Exchange
Act as the same may be amended from time to time, as any successor provision.

             (x) "Share" means a share of the Common Stock, as adjusted in
accordance with Section 13 below.




                                      -9-
<PAGE>   3

             (y) "Stock Purchase Right" means the right to purchase Common Stock
pursuant to Section 11 below.

             (z) "Subsidiary" means a "subsidiary corporation", whether now or
hereafter existing, as defined in Section 424(f) of the Code.

         3. Stock Subject to the Plan. Subject to the provisions of Section 13
of the Plan, the maximum aggregate number of shares which may be optioned and
sold under the Plan is 2,000,000 shares of Common Stock. The shares may be
authorized, but unissued, or reacquired Common Stock.

            If an Option should expire or become unexercisable for any reason
without having been exercised in full, the unpurchased Shares which were subject
thereto shall, unless the Plan shall have been terminated, become available for
future grant under the Plan.

            Notwithstanding any other provision of the Plan, Shares issued under
the Plan and later repurchased by the Company shall not become available for
future grant or sale under the Plan.

         4. Administration of the Plan.

            (a) Composition of the Administrator.

                (i) Multiple Administrative Bodies. If permitted by Rule 16b-3
and by the legal requirements relating to the administration of incentive stock
option plans, if any, of the applicable securities laws and the Code
(collectively the "Applicable Laws"), grants and sales under the Plan may (but
need not) be made by different administrative bodies with respect to Directors,
Officers who are not directors and Employees who are neither Directors nor
Officers.

                (ii) Administration With Respect to Directors and Officers. With
respect to grants of Options or Stock Purchase Rights to Employees or
Consultants who are also Officers or Directors of the Company, grants or sales
under the Plan shall be made by (A) the Board if the Board may make grants or
sales under the Plan in compliance with Rule 16b-3 and Section 162(m) of the
Code as it applies so as to qualify grants of Options or Stock Purchase Rights
to Named Executives as performance-based compensation, or (B) a Committee
designated by the Board to make grants or sales under the Plan, which committee
shall be constituted in such a manner as to permit grants or sales under the
Plan to comply with Rule 16b-3, to qualify grants of Options or Stock Purchase
Rights to Named Executives as performance-based compensation under Section
162(m) of the Code and otherwise so as to satisfy the Applicable Laws.

                (iii) Administration With Respect to Other Persons. With respect
to grants of Options or Stock Purchase Rights to Employees or Consultants who
are neither Directors nor Officers of the Company, the Plan shall be
administered by (A) the Board or (B) a committee designated by the Board, which
committee shall be constituted in such a manner as to satisfy the Applicable
Laws.

                (iv) General. If a Committee has been appointed pursuant to
subsection (ii) or (iii) of this Section 4(a), such Committee shall continue to
serve in its designated capacity until otherwise directed by the Board. From
time to time the Board may increase the size of the Committee and appoint
additional members thereof, remove members



                                      -10-
<PAGE>   4
(with or without cause) and appoint new members in substitution therefor, fill
vacancies, however caused, and remove all members of the Committee and
thereafter directly administer the Plan, all to the extent permitted by the
Applicable Laws and, in the case of a Committee appointed under subsection (ii)
of this Section 4(a), to the extent permitted by Rule 16b-3, and to the extent
required under Section 162(m) of the Code to qualify grants of Options or Stock
Purchase Rights to Named Executives as performance-based compensation.

            (b) Powers of the Administrator. Subject to the provisions of the
Plan and in the case of a Committee, the specific duties delegated by the Board
to such Committee, and subject to the approval of any relevant authorities,
including the approval, if required, of any stock exchange upon which the Common
Stock is listed, the Administrator shall have the authority, in its discretion:

                (i) to determine the Fair Market Value of the Common Stock, in
accordance with Section 2(l) of the Plan;

                (ii) to select the Consultants and Employees to whom Options and
Stock Purchase Rights may from time to time be granted hereunder;

                (iii) to determine whether and to what extent Options and Stock
Purchase Rights or any combination thereof are granted hereunder;

                (iv) to determine the number of shares of Common Stock to be
covered by each such award granted hereunder;

                (v) to approve forms of agreement for use under the Plan;

                (vi) to determine the terms and conditions, not inconsistent
with the terms of the Plan, of any award granted hereunder;

                (vii) to determine whether and under what circumstances an
Option may be settled in cash under subsection 10(f) instead of Common Stock;

                (viii) to reduce the exercise price of any Option to the then
current Fair Market Value if the Fair Market Value of the Common Stock covered
by such Option shall have declined since the date the Option was granted; and

                (ix) to determine the terms and restrictions applicable to Stock
Purchase Rights and the Restricted Stock purchased by exercising such Stock
Purchase Rights.

            (c) Effect of Administrator's Decision. All decisions,
determinations and interpretations of the Administrator shall be final and
binding on all Optionees and any other holders of any Options or Stock Purchase
Rights.

         5. Eligibility.

            (a) Nonstatutory Stock Options and Stock Purchase Rights may be
granted to Employees and Consultants. Incentive Stock Options may be granted
only to Employees. An Employee or Consultant who has been granted an Option or
Stock Purchase Right may, if he is otherwise eligible, be granted additional
Options or Stock Purchase Rights.




                                      -11-
<PAGE>   5
            (b) Each Option shall be designated in the written option agreement
as either an Incentive Stock Option or a Nonstatutory Stock Option. However,
notwithstanding such designations, to the extent that the aggregate Fair Market
Value of the Shares with respect to which Options designated as Incentive Stock
Options are exercisable for the first time by any Optionee during any calendar
year (under all plans of the Company or any Parent or Subsidiary) exceeds
$100,000, such excess Options shall be treated as Nonstatutory Stock Options.
For purposes of this section, Incentive Stock Options shall be taken into
account in the order in which they were granted, and the Fair Market Value of
the Shares shall be determined as of the time the Option with respect to such
Shares is granted.

            (c) The Plan shall not confer upon any Optionee any right with
respect to continuation of employment or consulting relationship with the
Company, nor shall it interfere in any way with his or her right or the
Company's right to terminate his or her employment or consulting relationship at
any time, with or without cause.

         6. Term of Plan. The Plan shall become effective upon the earlier to
occur of its adoption by the Board of Directors or its approval by the
shareholders of the Company as described in Section 21 of the Plan. It shall
continue in effect for a term of ten (10) years unless sooner terminated under
Section 17 of the Plan.

         7. Term of Option. The term of each Option shall be the term stated in
the Option Agreement; provided, however, that in the case of an Incentive Stock
Option, the term shall be no more than ten (10) years from the date of grant
thereof or such shorter term as may be provided in the Option Agreement.
However, in the case of an Option granted to an Optionee who, at the time the
Option is granted, owns stock representing more than ten percent (10%) of the
voting power of all classes of stock of the Company or any Parent or Subsidiary,
the term of the Option shall be five (5) years from the date of grant thereof or
such shorter term as may be provided in the Option Agreement.

         8. Limitation on Grants to Employees. Subject to adjustment as provided
in this Plan, the maximum number of Shares which may be subject to Options or
Stock Purchase Rights granted to any one Employee under this Plan for any fiscal
year of the Company shall be 150,000.

         9. Option Exercise Price and Consideration.

            (a) The per Share exercise price for the Shares to be issued
pursuant to exercise of an Option shall be such price as is determined by the
Administrator, but shall be subject to the following:

                (i) In the case of an Incentive Stock Option

                    (A) granted to an Employee who, at the time of the grant of
such Incentive Stock Option, owns stock representing more than ten percent (10%)
of the voting power of all classes of stock of the Company or any Parent or
Subsidiary, the per Share exercise price shall be no less than 110% of the Fair
Market Value per Share on the date of grant.

                    (B) granted to any other Employee, the per Share exercise
price shall be no less than 100% of the Fair Market Value per Share on the date
of grant.
                (ii) In the case of a Nonstatutory Stock Option

                     (A) granted to a person who, at the time of the grant of
such Option, is a Named Executive of the Company, the per Share exercise price
shall be no less than one hundred percent (100%) of the Fair market Value on the
date of grant; or



                                      -12-
<PAGE>   6
                     (B) granted to any person other than a Named Executive, the
per Share exercise price shall be no less than 85% of the Fair Market Value per
Share on the date of grant.

                (iii) Notwithstanding anything to the contrary in subsections
9(a)(i) or 9(a)(ii) above, in the case of an Option granted on or after the
effective date of registration of any class of equity security of the Company
pursuant to Section 12 of the Exchange Act and prior to six months after the
termination of such registration, the per Share exercise price shall be no less
than 100% of the Fair Market Value per Share on the date of grant.

            (b) The consideration to be paid for the Shares to be issued upon
exercise of an Option, including the method of payment, shall be determined by
the Administrator (and, in the case of an Incentive Stock Option, shall be
determined at the time of grant) and may consist entirely of (1) cash, (2)
check, (3) promissory note, (4) other Shares which (x) in the case of Shares
acquired upon exercise of an Option either have been owned by the Optionee for
more than six months on the date of surrender or were not acquired, directly or
indirectly, from the Company, and (y) have a Fair Market Value on the date of
surrender equal to the aggregate exercise price of the Shares as to which said
Option shall be exercised, (5) authorization from the Company to retain from the
total number of Shares as to which the Option is exercised that number of Shares
having a Fair Market Value on the date of exercise equal to the exercise price
for the total number of Shares as to which the Option is exercised, (6) delivery
of a properly executed exercise notice together with such other documentation as
the Administrator and the broker, if applicable, shall require to effect an
exercise of the Option and delivery to the Company of the sale or loan proceeds
required to pay the exercise price, (7) any combination of the foregoing methods
of payment, (8) or such other consideration and method of payment for the
issuance of Shares to the extent permitted under Applicable Laws. In making its
determination as to the type of consideration to accept, the Board shall
consider if acceptance of such consideration may be reasonably expected to
benefit the Company.

         10. Exercise of Option.

            (a) Procedure for Exercise; Rights as a Shareholder. Any Option
granted hereunder shall be exercisable at such times and under such conditions
as determined by the Administrator, including performance criteria with respect
to the Company and/or the Optionee, and as shall be permissible under the terms
of the Plan.

                An Option may not be exercised for a fraction of a Share.

                An Option shall be deemed to be exercised when written notice of
such exercise has been given to the Company in accordance with the terms of the
Option by the person entitled to exercise the Option and full payment for the
Shares with respect to which the Option is exercised has been received by the
Company. Full payment may, as authorized by the Administrator, consist of any
consideration and method of payment allowable under Section 9(b) of the Plan.
Until the issuance (as evidenced by the appropriate entry on the books of the
Company or of a duly authorized transfer agent of the Company) of the stock
certificate evidencing such Shares, no right to vote or receive dividends or any
other rights as a shareholder shall exist with respect to the Optioned Stock,
notwithstanding the exercise of the Option. The Company shall issue (or cause to
be issued) such stock certificate as promptly as practicable upon exercise of
the Option. No adjustment will be made for a dividend or other right for which
the record date is prior to the date the stock certificate is issued, except as
provided in Section 14 of the Plan.




                                      -13-
<PAGE>   7
                Exercise of an Option in any manner shall result in a decrease
in the number of Shares which thereafter may be available, both for purposes of
the Plan and for sale under the Option, by the number of Shares as to which the
Option is exercised.

            (b) Termination of Status as an Employee or Consultant. In the event
of termination of an Optionee's Continuous Status as an Employee or Consultant,
such Optionee may, but only within thirty (30) days (or such other period of
time, not exceeding three (3) months in the case of an Incentive Stock Option or
six (6) months in the case of a Nonstatutory Stock Option, as is determined by
the Administrator, with such determination in the case of an Incentive Stock
Option being made at the time of grant of the Option) after the date of such
termination (but in no event later than the date of expiration of the term of
such Option as set forth in the Option Agreement), exercise his or her Option to
the extent that he or she was entitled to exercise it at the date of such
termination. To the extent that the Optionee was not entitled to exercise the
Option at the date of such termination, or if the optionee does not exercise
such Option (which he or she was entitled to exercise) within the time specified
herein, the Option shall terminate.

            (c) Disability of Optionee.

                (i) Notwithstanding the provisions of Section 9(b) above, in the
         event of termination of an Optionee's Continuous Status as an Employee
         or Consultant as a result of his or her total and permanent disability
         (within the meaning of Section 22(e)(3) of the Code), Optionee may, but
         only within twelve (12) months from the date of such termination (but
         in no event later than the expiration date of the term of such Option
         as set forth in the Option Agreement), exercise the Option to the
         extent otherwise entitled to exercise it at the date of such
         termination. To the extent that Optionee was not entitled to exercise
         the Option at the date of termination, or if Optionee does not exercise
         such Option to the extent so entitled within the time specified herein,
         the Option shall terminate.

                (ii) In the event of termination of an Optionee's Continuous
         Status as an Employee or Consultant as a result of a disability which
         does not fall within the meaning of total and permanent disability (as
         set forth in Section 22(e)(3) of the Code), Optionee may, but only
         within six (6) months from the date of such termination (but in no
         event later than the expiration date of the term of such Option as set
         forth in the Option Agreement), exercise the Option to the extent
         otherwise entitled to exercise it at the date of such termination.
         However, to the extent that such Optionee fails to exercise an Option
         which is an Incentive Stock Option within three (3) months of the date
         of such termination, the Option will not qualify for ISO treatment
         under the Code. To the extent that Optionee was not entitled to
         exercise the Option at the date of termination, or if Optionee does not
         exercise such Option to the extent so entitled within six months (6)
         from the date of termination, the Option shall terminate. 

            (d) Death of Optionee. In the event of the death of an Optionee
during the term of the Option who is at the time of death an Employee or
Consultant of the Company, the Option may be exercised, at any time within
twelve (12) months following the date of death (but in no event later than the
expiration date of the term of such Option as set forth in the Option
Agreement), by the Optionee's estate or by a person who acquired the right to
exercise the Option by bequest or inheritance, but only to the extent the
Optionee was entitled to exercise the Option at the date of death. To the extent
that Optionee was not entitled to exercise the Option at the date of
termination, or if Optionee does not exercise such Option to the extent so
entitled within the time specified herein, the Option shall terminate.

            (e) Rule 16b-3. Options granted to persons subject to Section 16(b)
of the Exchange Act must comply with Rule 16b-3 and shall contain such
additional conditions or restrictions as may be required thereunder to qualify
for the maximum exemption from Section 16 of the Exchange Act with respect to
Plan transactions.

            (f) Buyout Provisions. The Administrator may at any time offer to
buy out for a payment in cash or Shares, an Option previously granted, based on
such terms and conditions as the Administrator shall establish and communicate
to the Optionee at the time that such offer is made.



                                      -14-
<PAGE>   8
         11. Non-Transferability of Options. Option may not be sold, pledged,
assigned, hypothecated, transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution and may be exercised, during the
lifetime of the Optionee, only by the Optionee.

         12. Stock Purchase Rights.

            (a) Rights to Purchase. Stock Purchase Rights may be issued either
alone, in addition to, or in tandem with other awards granted under the Plan
and/or cash awards made outside of the Plan. After the Administrator determines
that it will offer Stock Purchase Rights under the Plan, it shall advise the
offeree in writing of the terms, conditions and restrictions related to the
offer, including the number of Shares that such person shall be entitled to
purchase, the price to be paid (which price shall not be less than 85% of the
Fair Market Value of the Shares as of the date of the offer or, in the case of a
shareholder owning ten percent (10%) or more of the Company's outstanding stock
or a person who is a Named Executive, 100% of the Fair Market Value of the
Shares as of the date of the offer), and the time within which such person must
accept such offer, which shall in no event exceed thirty (30) days from the date
upon which the Administrator made the determination to grant the Stock Purchase
Right. The offer shall be accepted by execution of a Restricted Stock purchase
agreement in the form determined by the Administrator. Shares purchased pursuant
to the grant of a Stock Purchase Right shall be referred to herein as
"Restricted Stock."

            (b) Repurchase Option. Unless the Administrator determines
otherwise, the Restricted Stock purchase agreement shall grant the Company a
repurchase option exercisable upon the voluntary or involuntary termination of
the purchaser's employment with the Company for any reason (including death or
Disability). The purchase price for Shares repurchased pursuant to the
Restricted Stock purchase agreement shall be the original price paid by the
purchaser and may be paid by cancellation of any indebtedness of the purchaser
to the Company. The repurchase option shall lapse at such rate as the Board or
Committee may determine.

            (c) Other Provisions. The Restricted Stock purchase agreement shall
contain such other terms, provisions and conditions not inconsistent with the
Plan as may be determined by the Administrator in its sole discretion. In
addition, the provisions of Restricted Stock purchase agreements need not be the
same with respect to each purchaser.

            (d) Rights as a Shareholder. Once the Stock Purchase Right is
exercised, the purchaser shall have the rights equivalent to those of a
shareholder, and shall be a shareholder when his or her purchase is entered upon
the records of the duly authorized transfer agent of the Company. No adjustment
will be made for a dividend or other right for which the record date is prior to
the date the Stock Purchase Right is exercised, except as provided in Section 14
of the Plan.

         13. Withholding Taxes. As a condition to the exercise of Options or the
purchase of Restricted Stock pursuant to awards granted hereunder, the Optionee
or purchaser shall make such arrangements as the Administrator may require for
the satisfaction of any federal, state, local or foreign withholding tax
obligations that may arise in connection with the exercise, receipt or vesting
of such award. The Company shall not be required to issue any Shares under the
Plan until such obligations are satisfied.

         14. Stock Withholding to Satisfy Withholding Tax Obligations. At the
discretion of the Administrator, Optionees may satisfy withholding obligations
as provided in this paragraph. When an Optionee incurs tax liability in
connection with an Option or Stock Purchase Right, which tax liability is
subject to tax withholding under applicable tax laws, and the Optionee is
obligated to pay the Company an amount required to be withheld under applicable
tax laws, the Optionee may satisfy the withholding tax obligation by electing to
have the Company withhold from the Shares to be issued upon exercise of the
Option, or the Shares to be issued in connection with the Stock Purchase Right,
if any, that number of Shares having a Fair Market Value equal to the amount
required to be withheld. The Fair Market Value of the Shares to be withheld
shall be determined on the date that the amount of tax to be withheld is to be
determined (the "Tax Date").





                                      -15-
<PAGE>   9
             Any surrender by an Officer or Director of previously owned Shares
to satisfy tax withholding obligations arising upon exercise of this Option must
comply with the applicable provisions of Rule 16b-3.

             All elections by an Optionee to have Shares withheld for this
purpose shall be made in writing in a form acceptable to the Administrator and
shall be subject to the following restrictions:

             (a) the election must be made on or prior to the applicable Tax
Date;

             (b) once made, the election shall be irrevocable as to the
particular Shares of the Option or Stock Purchase Right as to which the election
is made; and

             (c) all elections shall be subject to the consent or disapproval of
the Administrator.

             In the event the election to have Shares withheld is made by an
Optionee and the Tax Date is deferred under Section 83 of the Code because no
election is filed under Section 83(b) of the Code, the Optionee shall receive
the full number of Shares with respect to which the Option or Stock Purchase
Right is exercised but such Optionee shall be unconditionally obligated to
tender back to the Company the proper number of Shares on the Tax Date.

         15. Adjustments Upon Changes in Capitalization; Corporate Transaction.

             (a) Changes in Capitalization. Subject to any required action by
the shareholders of the Company, the number of shares of Common Stock covered by
each outstanding Option or Stock Purchase Right, and the number of shares of
Common Stock which have been authorized for issuance under the Plan but as to
which no Options or Stock Purchase Rights have yet been granted or which have
been returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, as well as the price per share of Common Stock covered by each
such outstanding Option or Stock Purchase Right, shall be proportionately
adjusted for any increase or decrease in the number of issued shares of Common
Stock resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Common Stock, or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of consideration by the Company; provided, however, that conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or price of shares of Common Stock subject to an Option or Stock
Purchase Right.

             (b) Corporate Transactions. In the event of a dissolution or
liquidation of the Company, the Option will terminate immediately prior to the
consummation of such action, unless otherwise provided by the Administrator. The
Administrator may, in the exercise of its sole discretion in such instances,
declare that any Option shall terminate as of a date fixed by the Administrator
and give each Optionee the right to exercise his or her Option as to all of the
Optioned Stock, including Shares as to which the Option would not otherwise be
exercisable. In the event of a proposed sale of all or substantially all of the
assets of the Company, the merger of the Company with or into another
corporation or any other capital reorganization in which more than fifty percent
(50%) of the shares of the Company entitled to vote are exchanged, the Option
shall be assumed or an equivalent option shall be substituted by such successor
corporation or a parent or subsidiary of such successor corporation, unless the
Administrator determines, in the exercise of its sole discretion and in lieu of
such assumption or substitution, that the Optionee shall have the right to
exercise the Option as to all of the Optioned Stock, including Shares as to
which the Option would not otherwise be exercisable. If the Administrator makes
an Option exercisable in lieu of assumption or substitution in the event of a
merger or sale of assets, the Administrator shall notify the Optionee that the
Option shall be exercisable for a period of thirty (30) days from the date of
such notice, and the Option will terminate upon the expiration of such period.




                                      -16-
<PAGE>   10
         16. Time of Granting Options and Stock Purchase Rights. The date of
grant of an Option or Stock Purchase Right shall, for all purposes, be the date
on which the Administrator makes the determination granting such Option or Stock
Purchase Right, or such other date as is determined by the Administrator;
provided however that in the case of any Incentive Stock Option, the grant date
shall be the later of the date on which the Administrator makes the
determination granting such Incentive Stock Option or the date of commencement
of the Optionee's employment relationship with the Company. Notice of the
determination shall be given to each Employee or Consultant to whom an Option or
Stock Purchase Right is so granted within a reasonable time after the date of
such grant.

         17. Amendment and Termination of the Plan.

             (a) Amendment and Termination. The Board may amend or terminate the
Plan from time to time in such respects as the Board may deem advisable;
provided, however, that the following revisions or amendments shall require
approval of the shareholders of the Company in the manner described in Section
20 of the Plan:

                 (i) any increase in the number of Shares subject to the Plan,
other than in connection with an adjustment under Section 15 above;

                 (ii) any change in the designation of the class of persons
eligible to be granted Options;

                 (iii) any change in the limitation on grants to employees as
described in Section 8 of the Plan or other changes which would require
shareholder approval to qualify options granted hereunder as performance-based
compensation under Section 162(m) of the Code; or

                 (iv) any revision or amendment requiring shareholder approval
in order to preserve the qualification of the Plan under Rule 16b-3.

             (b) Shareholder Approval. If any amendment requiring shareholder
approval under Section 13(a) above is made subsequent to the first registration
of any class of equity security by the Company under Section 12 of the Exchange
Act, then such shareholder approval shall be solicited as described in Section
20 below.

             (c) Effect of Amendment or Termination. Any such amendment or
termination of the Plan shall not affect Options already granted and such
Options shall remain in full force and effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Board, which agreement must be in writing and signed by the Optionee and the
Company.

         18. Conditions Upon Issuance of Shares. Shares shall not be issued
pursuant to the exercise of an Option or Stock Purchase Right unless the
exercise of such Option and the issuance and delivery of such Shares pursuant
thereto shall comply with all relevant provisions of law, including, without
limitation, the Securities Act of 1933, as amended, the Exchange Act, the rules
and regulations promulgated thereunder, and the requirements of any stock
exchange upon which the Shares may then be listed, and shall be further subject
to the approval of counsel for the Company with respect to such compliance.

             As a condition to the exercise of an Option or Stock Purchase
Right, the Company may require the person exercising such Option or Stock
Purchase Right to represent and warrant at the time of any such exercise that
the Shares are being purchased only for investment and without any present
intention to sell or distribute such Shares if, in the opinion of counsel for
the Company, such a representation is required by any of the aforementioned
relevant provisions of law.




                                      -17-
<PAGE>   11
         19. Reservation of Shares. The Company, during the term of this Plan,
will at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan. The inability of the Company
to obtain authority from any regulatory body having jurisdiction, which
authority is deemed by the Company's counsel to be necessary to the lawful
issuance and sale of any Shares hereunder, shall relieve the Company of any
liability in respect of the failure to issue or sell such Shares as to which
such requisite authority shall not have been obtained.

         20. Agreements. Options and Stock Purchase Rights shall be evidenced by
written agreements in such form as the Board shall approve from time to time.

         21. Shareholder Approval.

             (a) Continuance of the Plan shall be subject to approval by the
shareholders of the Company within twelve (12) months before or after the date
the Plan is adopted. Such shareholder approval shall be obtained in the degree
and manner required under applicable state and federal law and the rules of any
stock exchange upon which the Common Stock is listed.

             (b) In the event that the Company registers any class of equity
securities pursuant to Section 12 of the Exchange Act, any required approval of
the shareholders of the Company obtained after such registration shall be
solicited substantially in accordance with Section 14(a) of the Exchange Act and
the rules and regulations promulgated thereunder.

             (c) If any required approval by the shareholders of the Plan itself
or of any amendment thereto is solicited at any time otherwise than in the
manner described in Section 20(b) hereof, then the Company shall, at or prior to
the first annual meeting of shareholders held subsequent to the later of (1) the
first registration of any class of equity securities of the Company under
Section 12 of the Exchange Act or (2) the granting of an Option hereunder to an
officer or director after such registration, do the following:

                 (i) furnish in writing to the holders entitled to vote for the
Plan substantially the same information that would be required (if proxies to be
voted with respect to approval or disapproval of the Plan or amendment were then
being solicited) by the rules and regulations in effect under Section 14(a) of
the Exchange Act at the time such information is furnished; and

                 (ii) file with, or mail for filing to, the Securities and
Exchange Commission four copies of the written information referred to in
subsection (i) hereof not later than the date on which such information is first
sent or given to shareholders.

         22. Information to Optionees and Purchasers. The Company shall provide
financial statements at least annually to each Optionee and to each individual
who acquired Shares Pursuant to the Plan, during the period such Optionee or
purchaser has one or more Options or Stock Purchase Rights outstanding, and in
the case of an individual who acquired Shares pursuant to the Plan, during the
period such individual owns such Shares. The Company shall not be required to
provide such information if the issuance of Options or Stock Purchase Rights
under the Plan is limited to key employees whose duties in connection with the
Company assure their access to equivalent information.




                                      -18-

<PAGE>   1
                                                                     EXHIBIT 4.4



                              CONNETICS CORPORATION

                        1995 EMPLOYEE STOCK PURCHASE PLAN
                        (AS AMENDED THROUGH MAY 23, 1997)



         The following constitute the provisions of the 1995 Employee Stock
Purchase Plan of Connetics Corporation.

         1. Purpose. The purpose of the Plan is to provide employees of the
Company and its Designated Subsidiaries with an opportunity to purchase Common
Stock of the Company. It is the intention of the Company to have the Plan
qualify as an "Employee Stock Purchase Plan" under Section 423 of the Internal
Revenue Code of 1986, as amended. The provisions of the Plan shall, accordingly,
be construed so as to extend and limit participation in a manner consistent with
the requirements of that section of the Code.

         2. Definitions.

            (a) "Board" shall mean the Board of Directors of the Company.

            (b) "Code" shall mean the Internal Revenue Code of 1986, as amended.

            (c) "Common Stock" shall mean the Common Stock of the Company.

            (d) "Company" shall mean Connetics Corporation a Delaware
corporation. Prior to May 15, 1997, the Company's name was Connective
Therapeutics, Inc.

            (e) "Compensation" shall mean all regular straight time gross
earnings, excluding payments for overtime, shift premium, incentive
compensation, incentive payments, bonuses, commissions and other compensation.

            (f) "Continuous Status as an Employee" shall mean the absence of any
interruption or termination of service as an Employee. Continuous Status as an
Employee shall not be considered interrupted in the case of a leave of absence
agreed to in writing by the Company, provided that such leave is for a period of
not more than 90 days or reemployment upon the expiration of such leave is
guaranteed by contract or statute.

            (g) "Contributions" shall mean all amounts credited to the account
of a participant pursuant to the Plan.

            (h) "Designated Subsidiaries" shall mean the Subsidiaries which have
been designated by the Board from time to time in its sole discretion as
eligible to participate in the Plan.




                                      -19-
<PAGE>   2
            (i) "Employee" shall mean any person, including an Officer, who is
customarily employed for at least twenty (20) hours per week and more than five
(5) months in a calendar year by the Company or one of its Designated
Subsidiaries.

            (j) "Exchange Act" shall mean the Securities Exchange Act of 1934,
as amended.

            (k) "Purchase Date" shall mean the last day of each Purchase Period
of the Plan.

            (l) "Offering Date" shall mean the first business day of each
Offering Period of the Plan, except that in the case of an individual who
becomes an eligible Employee after the first business day of an Offering Period
but prior to the first business day of the last calendar quarter of such
Offering Period, the term "Offering Date" shall mean the first business day of
the calendar quarter coinciding with or next succeeding the day on which that
individual becomes an eligible Employee.

                Options granted after the first business day of an Offering
Period will be subject to the same terms as the options granted on the first
business day of such Offering Period except that they will have a different
grant date (thus, potentially, a different exercise price) and, because they
expire at the same time as the options granted on the first business day of such
Offering Period, a shorter term.

            (m) "Offering Period" shall mean a period of twenty-four (24) months
commencing on December 1 and June 1 of each year, except for the first Offering
Period as set forth in Section 4(a).

            (n) "Officer" shall mean a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.

            (o) "Plan" shall mean this Employee Stock Purchase Plan.

            (p) "Purchase Period" shall mean a period of six (6) months within
an Offering Period, except for the first Purchase Period as set forth in Section
4(b).

            (q) "Subsidiary" shall mean a corporation, domestic or foreign, of
which not less than 50% of the voting shares are held by the Company or a
Subsidiary, whether or not such corporation now exists or is hereafter organized
or acquired by the Company or a Subsidiary.

         3. Eligibility.

            (a) Any person who is an Employee as of the Offering Date of a given
Offering Period shall be eligible to participate in such Offering Period under
the Plan subject to the requirements of Section 5(a) and the limitations imposed
by Section 423(b) of the Code.




                                      -20-
<PAGE>   3
            (b) Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) if, immediately after the
grant, such Employee (or any other person whose stock would be attributed to
such Employee pursuant to Section 424(d) of the Code) would own stock and/or
hold outstanding options to purchase stock possessing five percent (5%) or more
of the total combined voting power or value of all classes of stock of the
Company or of any subsidiary of the Company, or (ii) if such option would permit
his or her rights to purchase stock under all employee stock purchase plans
(described in Section 423 of the Code) of the Company and its Subsidiaries to
accrue at a rate which exceeds Twenty-Five Thousand Dollars ($25,000) of fair
market value of such stock (determined at the time such option is granted) for
each calendar year in which such option is outstanding at any time.

         4. Offering Periods and Purchase Periods.

            (a) Offering Periods. The Plan shall be implemented by a series of
Offering Periods of twenty-four (24) months duration, with new Offering Periods
commencing on or about June 1 and December 1 of each year (or at such other time
or times as may be determined by the Board of Directors). The first Offering
Period commenced on the beginning of the effective date of the Registration
Statement on Form S-1 for the initial public offering of the Company's Common
Stock (the "IPO Date") and continued until May 31, 1996. The Plan shall continue
until terminated in accordance with Section 20 hereof. The Board of Directors of
the Company shall have the power to change the duration and/or the frequency of
Offering Periods with respect to future offerings without stockholder approval
if such change is announced at least fifteen (15) days prior to the scheduled
beginning of the first Offering Period to be affected. Eligible employees may
not participate in more than one Offering Period at a time.

            (b) Purchase Periods. Each Offering Period shall consist of four (4)
consecutive purchase periods of six (6) months duration. The last day of each
Purchase Period shall be the "Purchase Date" for such Purchase Period. A
Purchase Period commencing on June 1 shall end on the next November 30. A
Purchase Period commencing on December 1 shall end on the next May 31. The first
Purchase Period commenced on the IPO Date and ended on May 31, 1996. The Board
of Directors of the Company shall have the power to change the duration and/or
frequency of Purchase Periods with respect to future purchases without
stockholder approval if such change is announced at least fifteen (15) days
prior to the scheduled beginning of the first Purchase Period to be affected.

         5. Participation.

            (a) An eligible Employee may become a participant in the Plan by
completing a subscription agreement on the form provided by the Company and
filing it with the Company's payroll office prior to the applicable Offering
Date, unless a later time for filing the subscription agreement is set by the
Board for all eligible Employees with respect to a given offering. The
subscription agreement shall set forth the percentage of the participant's
Compensation (which shall be not less than 1% and not more than 15%) to be paid
as Contributions pursuant to the Plan.

            (b) Payroll deductions shall commence on the first payroll following
the Offering Date and shall end on the last payroll paid on or prior to the last
Purchase Period of the Offering Period to which the subscription agreement is
applicable, unless sooner terminated by the participant as provided in Section
10.




                                      -21-
<PAGE>   4
         6. Method of Payment of Contributions.

            (a) The participant shall elect to have payroll deductions made on
each payday during the Offering Period in an amount not less than one percent
(1%) and not more than fifteen percent (15%) of such participant's Compensation
on each such payday. All payroll deductions made by a participant shall be
credited to his or her account under the Plan. A participant may not make any
additional payments into such account.

            (b) A participant may discontinue his or her participation in the
Plan as provided in Section 10, or, on one occasion only during the Offering
Period, may increase or decrease the rate of his or her Contributions during the
Offering Period by completing and filing with the Company a new subscription
agreement. The change in rate shall be effective as of the beginning of the
calendar quarter following the date of filing of the new subscription agreement.

            (c) Notwithstanding the foregoing, to the extent necessary to comply
with Section 423(b)(8) of the Code and Section 3(b) herein, a participant's
payroll deductions may be decreased to 0% at such time during any Offering
Period which is scheduled to end during the current calendar year that the
aggregate of all payroll deductions accumulated with respect to such Offering
Period and any other Offering Period ending within the same calendar year equal
$21,250. Payroll deductions shall re-commence at the rate provided in such
participant's subscription Agreement at the beginning of the first Offering
Period which is scheduled to end in the following calendar year, unless
terminated by the participant as provided in Section 10.

         7. Grant of Option.

            (a) On the Offering Date of each Offering Period, each eligible
Employee participating in such Offering Period shall be granted an option to
purchase on each Purchase Date a number of shares of the Company's Common Stock
determined by dividing such Employee's Contributions accumulated prior to such
Purchase Date and retained in the participant's account as of the Purchase Date
by the lower of (i) eighty-five percent (85%) of the fair market value of a
share of the Company's Common Stock on the Offering Date, or (ii) eighty-five
percent (85%) of the fair market value of a share of the Company's Common Stock
on the Purchase Date; provided however, that the maximum number of shares an
Employee may purchase during each Offering Period shall be determined at the
Offering Date by dividing $50,000 by the fair market value of a share of the
Company's Common Stock on the Offering Date, and provided further that such
purchase shall be subject to the limitations set forth in Sections 3(b) and 12.
The fair market value of a share of the Company's Common Stock shall be
determined as provided in Section 7(b).

            (b) The option price per share of the shares offered in a given
Offering Period shall be the lower of: (i) 85% of the fair market value of a
share of the Common Stock of the Company on the Offering Date; or (ii) 85% of
the fair market value of a share of the Common Stock of the Company on the
Purchase Date. The fair market value of the Company's Common Stock on a given
date shall be determined by the Board in its discretion based on the closing
price of the Common Stock for such date (or, in the event that the Common Stock
is not traded on such date, on the immediately preceding trading date), as
reported by the National Association




                                      -22-
<PAGE>   5
of Securities Dealers Automated Quotation (Nasdaq) National Market or, if such
price is not reported, the mean of the bid and asked prices per share of the
Common Stock as reported by Nasdaq or, in the event the Common Stock is listed
on a stock exchange, the fair market value per share shall be the closing price
on such exchange on such date (or, in the event that the Common Stock is not
traded on such date, on the immediately preceding trading date), as reported in
The Wall Street Journal. For purposes of the Offering Date under the first
Offering Period under the Plan, the fair market value of a share of the Common
Stock of the Company shall be the Price to Public as set forth in the final
prospectus filed with the Securities and Exchange Commission pursuant to Rule
424 under the Securities Act of 1933, as amended.

         8. Exercise of Option. Unless a participant withdraws from the Plan as
provided in paragraph 10, his or her option for the purchase of shares will be
exercised automatically on each Purchase Date of an Offering Period, and the
maximum number of shares, including fractional shares, subject to the option
will be purchased at the applicable option price with the accumulated
Contributions in his or her account. The shares purchased upon exercise of an
option hereunder shall be deemed to be transferred to the participant on the
Purchase Date. During his or her lifetime, a participant's option to purchase
shares hereunder is exercisable only by him or her.

         9. Delivery. As promptly as practicable after each Purchase Date of
each Offering Period, the Company shall arrange the delivery to each
participant, as appropriate, of a certificate representing the shares purchased
upon exercise of his or her option or the deposit of such number of shares with
the broker selected by the Company for administration of Plan stock purchases,
as determined by the Company. Any cash remaining to the credit of a
participant's account under the Plan after a purchase by him or her of shares at
the termination of each Offering Period, or which is insufficient to purchase a
full share of Common Stock of the Company, shall be carried over to the next
Offering Period if the Employee continues to participate in the Plan, or if the
Employee does not continue to participate, shall be returned to said
participant.

         10. Voluntary Withdrawal; Termination of Employment.

             (a) A participant may withdraw all but not less than all the
Contributions credited to his or her account under the Plan at any time prior to
each Purchase Date by giving written notice to the Company. All of the
participant's Contributions credited to his or her account will be paid to him
or her promptly after receipt of his or her notice of withdrawal and his or her
option for the current period will be automatically terminated, and no further
Contributions for the purchase of shares will be made during the Offering
Period.

             (b) Upon termination of the participant's Continuous Status as an
Employee prior to the Purchase Date of an Offering Period for any reason,
including retirement or death, the Contributions credited to his or her account
will be returned to him or her or, in the case of his or her death, to the
person or persons entitled thereto under Section 14, and his or her option will
be automatically terminated.

             (c) In the event an Employee fails to remain in Continuous Status
as an Employee of the Company for at least twenty (20) hours per week during the
Offering Period in which the employee is a participant, he or she will be deemed
to have elected to withdraw from the Plan and the Contributions credited to his
or her account will be returned to him or her and his or her option terminated.




                                      -23-
<PAGE>   6
             (d) A participant's withdrawal from an offering will not have any
effect upon his or her eligibility to participate in a succeeding offering or in
any similar plan which may hereafter be adopted by the Company.

         11. Automatic Withdrawal. If the fair market value of the shares on the
first Purchase Date of an Offering Period is less than the fair market value of
the shares on the Offering Date for such Offering Period, then every participant
shall automatically (i) be withdrawn from such Offering Period at the close of
such Purchase Date and after the acquisition of shares for such Purchase Period,
and (ii) be enrolled in the Offering Period commencing on the first business day
subsequent to such Purchase Period.

         12. Interest. No interest shall accrue on the Contributions of a
participant in the Plan.

         13. Stock.

             (a) The maximum number of shares of the Company's Common Stock
which shall be made available for sale under the Plan shall be 100,000 shares,
subject to adjustment upon changes in capitalization of the Company as provided
in Section 18. If the total number of shares which would otherwise be subject to
options granted pursuant to Section 7(a) on the Offering Date of an Offering
Period exceeds the number of shares then available under the Plan (after
deduction of all shares for which options have been exercised or are then
outstanding), the Company shall make a pro rata allocation of the shares
remaining available for option grant in as uniform a manner as shall be
practicable and as it shall determine to be equitable. In such event, the
Company shall give written notice of such reduction of the number of shares
subject to the option to each Employee affected thereby and shall similarly
reduce the rate of Contributions, if necessary.

             (b) The participant will have no interest or voting right in shares
covered by his or her option until such option has been exercised.

             (c) Shares to be delivered to a participant under the Plan will be
registered in the name of the participant or in the name of the participant and
his or her spouse.

         14. Administration. The Board, or a committee named by the Board, shall
supervise and administer the Plan and shall have full power to adopt, amend and
rescind any rules deemed desirable and appropriate for the administration of the
Plan and not inconsistent with the Plan, to construe and interpret the Plan, and
to make all other determinations necessary or advisable for the administration
of the Plan. The composition of the committee shall be in accordance with the
requirements to obtain or retain any available exemption from the operation of
Section 16(b) of the Exchange Act pursuant to Rule 16b-3 promulgated thereunder.

         15. Designation of Beneficiary.

             (a) A participant may file a written designation of a beneficiary
who is to receive any shares and cash, if any, from the participant's account
under the Plan in the event of such participant's death subsequent to the end of
a Purchase Period but prior to delivery to him or her of such shares and cash.
In addition, a participant may file a written designation of a beneficiary who
is to receive any cash from the participant's account under the Plan in the
event of such participant's death prior to the Purchase Date of an Offering
Period. If a participant is




                                      -24-
<PAGE>   7
married and the designated beneficiary is not the spouse, spousal consent shall
be required for such designation to be effective.

             (b) Such designation of beneficiary may be changed by the
participant (and his or her spouse, if any) at any time by written notice. In
the event of the death of a participant and in the absence of a beneficiary
validly designated under the Plan who is living at the time of such
participant's death, the Company shall deliver such shares and/or cash to the
executor or administrator of the estate of the participant, or if no such
executor or administrator has been appointed (to the knowledge of the Company),
the Company, in its discretion, may deliver such shares and/or cash to the
spouse or to any one or more dependents or relatives of the participant, or if
no spouse, dependent or relative is known to the Company, then to such other
person as the Company may designate.

         16. Transferability. Neither Contributions credited to a participant's
account nor any rights with regard to the exercise of an option or to receive
shares under the Plan may be assigned, transferred, pledged or otherwise
disposed of in any way (other than by will, the laws of descent and
distribution, or as provided in Section 14) by the participant. Any such attempt
at assignment, transfer, pledge or other disposition shall be without effect,
except that the Company may treat such act as an election to withdraw funds in
accordance with Section 10.

         17. Use of Funds. All Contributions received or held by the Company
under the Plan may be used by the Company for any corporate purpose, and the
Company shall not be obligated to segregate such Contributions.

         18. Reports. Individual accounts will be maintained for each
participant in the Plan. Statements of account will be given to participating
Employees promptly following the Purchase Date, which statements will set forth
the amounts of Contributions, the per share purchase price, the number of shares
purchased and the remaining cash balance, if any.

         19. Adjustments Upon Changes in Capitalization; Corporate Transactions.

             (a) Adjustment. Subject to any required action by the shareholders
of the Company, the number of shares of Common Stock covered by each option
under the Plan which has not yet been exercised and the number of shares of
Common Stock which have been authorized for issuance under the Plan but have not
yet been placed under option (collectively, the "Reserves"), as well as the
price per share of Common Stock covered by each option under the Plan which has
not yet been exercised, shall be proportionately adjusted for any increase or
decrease in the number of issued shares of Common Stock resulting from a stock
split, reverse stock split, stock dividend, combination or reclassification of
the Common Stock, or any other increase or decrease in the number of shares of
Common Stock effected without receipt of consideration by the Company; provided,
however, that conversion of any convertible securities of the Company shall not
be deemed to have been "effected without receipt of consideration". Such
adjustment shall be made by the Board, whose determination in that respect shall
be final, binding and conclusive. Except as expressly provided herein, no issue
by the Company of shares of stock of any class, or securities convertible into
shares of stock of any class, shall affect, and no adjustment by reason thereof
shall be made with respect to, the number or price of shares of Common Stock
subject to an option.

             (b) Corporate Transactions. In the event of the proposed
dissolution or liquidation of the Company, the Offering Period will terminate
immediately prior to the consummation of such proposed action, unless otherwise
provided by the Board. In the event of a proposed sale of all or substantially
all of the assets of the Company, or the merger of the Company with or into
another corporation, each option under the Plan shall be assumed or an
equivalent option shall be substituted by such successor corporation or a parent
or subsidiary of such successor corporation, unless the Board determines, in the
exercise of its sole discretion and in lieu of such assumption or substitution,
to shorten the Offering Period then in progress by setting a new Purchase Date
(the




                                      -25-
<PAGE>   8
"New Purchase Date"). If the Board shortens the Offering Period then in progress
in lieu of assumption or substitution in the event of a merger or sale of
assets, the Board shall notify each participant in writing, at least ten (10)
days prior to the New Purchase Date, that the Purchase Date for his or her
option has been changed to the New Purchase Date and that his or her option will
be exercised automatically on the New Purchase Date, unless prior to such date
he or she has withdrawn from the Offering Period as provided in Section 10. For
purposes of this paragraph, an option granted under the Plan shall be deemed to
be assumed if, following the sale of assets or merger, the option confers the
right to purchase, for each share of option stock subject to the option
immediately prior to the sale of assets or merger, the consideration (whether
stock, cash or other securities or property) received in the sale of assets or
merger by holders of Common Stock for each share of Common Stock held on the
effective date of the transaction (and if such holders were offered a choice of
consideration, the type of consideration chosen by the holders of a majority of
the outstanding shares of Common Stock); provided, however, that if such
consideration received in the sale of assets or merger was not solely common
stock of the successor corporation or its parent (as defined in Section 424(e)
of the Code), the Board may, with the consent of the successor corporation and
the participant, provide for the consideration to be received upon exercise of
the option to be solely common stock of the successor corporation or its parent
equal in fair market value to the per share consideration received by holders of
Common Stock and the sale of assets or merger.

             The Board may, if it so determines in the exercise of its sole
discretion, also make provision for adjusting the Reserves, as well as the price
per share of Common Stock covered by each outstanding option, in the event that
the Company effects one or more reorganizations, recapitalizations, rights
offerings or other increases or reductions of shares of its outstanding Common
Stock, and in the event of the Company being consolidated with or merged into
any other corporation.

         20. Amendment or Termination.

             (a) The Board of Directors of the Company may at any time terminate
or amend the Plan. Except as provided in Section 19, no such termination may
affect options previously granted, nor may an amendment make any change in any
option theretofore granted which adversely affects the rights of any
participant. In addition, to the extent necessary to comply with Rule 16b-3
under the Exchange Act, or under Section 423 of the Code (or any successor rule
or provision or any applicable law or regulation), the Company shall obtain
shareholder approval in such a manner and to such a degree as so required.

             (b) Without shareholder consent and without regard to whether any
participant rights may be considered to have been adversely affected, the Board
(or its committee) shall be entitled to change the Offering Periods and Purchase
Periods, limit the frequency and/or number of changes in the amount withheld
during an Offering Period, establish the exchange ratio applicable to amounts
withheld in a currency other than U.S. dollars, permit payroll withholding in
excess of the amount designated by a participant in order to adjust for delays
or mistakes in the Company's processing of properly completed withholding
elections, establish reasonable waiting and adjustment periods and/or accounting
and crediting procedures to ensure that amounts applied toward the purchase of
Common Stock for each participant properly correspond with amounts withheld from
the participant's Compensation, and establish such other limitations or
procedures as the Board (or its committee) determines in its sole discretion
advisable which are consistent with the Plan.

         21. Notices. All notices or other communications by a participant to
the Company under or in connection with the Plan shall be deemed to have been
duly given when received in the form specified by the Company at the location,
or by the person, designated by the Company for the receipt thereof.




                                      -26-
<PAGE>   9
         22. Conditions Upon Issuance of Shares. Shares shall not be issued with
respect to an option unless the exercise of such option and the issuance and
delivery of such shares pursuant thereto shall comply with all applicable
provisions of law, domestic or foreign, including, without limitation, the
Securities Act of 1933, as amended, the Exchange Act, the rules and regulations
promulgated thereunder, and the requirements of any stock exchange upon which
the shares may then be listed, and shall be further subject to the approval of
counsel for the Company with respect to such compliance.

                  As a condition to the exercise of an option, the Company may
require the person exercising such option to represent and warrant at the time
of any such exercise that the shares are being purchased only for investment and
without any present intention to sell or distribute such shares if, in the
opinion of counsel for the Company, such a representation is required by any of
the aforementioned applicable provisions of law.

         23. Term of Plan; Effective Date. The Plan shall become effective upon
the earlier to occur of its adoption by the Board of Directors or its approval
by the shareholders of the Company. It shall continue in effect for a term of
twenty (20) years unless sooner terminated under Section 20.

         24. Additional Restrictions of Rule 16b-3. The terms and conditions of
options granted hereunder to, and the purchase of shares by, persons subject to
Section 16 of the Exchange Act shall comply with the applicable provisions of
Rule 16b-3. This Plan shall be deemed to contain, and such options shall
contain, and the shares issued upon exercise thereof shall be subject to, such
additional conditions and restrictions as may be required by Rule 16b-3 to
qualify for the maximum exemption from Section 16 of the Exchange Act with
respect to Plan transactions.







                                      -27-
<PAGE>   10
                              CONNETICS CORPORATION

                        1995 EMPLOYEE STOCK PURCHASE PLAN
                             SUBSCRIPTION AGREEMENT




                                                             New Election ______
                                                       Change of Election ______


         1. I, ________________________, hereby elect to participate in the
CONNETICS CORPORATION 1995 Employee Stock Purchase Plan (the "Plan") for the
Offering Period ______________, 19__ to _______________, 19__, and subscribe to
purchase shares of the Company's Common Stock in accordance with this
Subscription Agreement and the Plan.

         2. I elect to have Contributions in the amount of ____% of my
Compensation, as those terms are defined in the Plan, applied to this purchase.
I understand that this amount must not be less than 1% and not more than 15% of
my Compensation during the Offering Period. (Please note that no fractional
percentages are permitted).

         3. I hereby authorize payroll deductions from each paycheck during the
Offering Period at the rate stated in Item 2 of this Subscription Agreement. I
understand that all payroll deductions made by me shall be credited to my
account under the Plan and that I may not make any additional payments into such
account. I understand that all payments made by me shall be accumulated for the
purchase of shares of Common Stock at the applicable purchase price determined
in accordance with the Plan. I further understand that, except as otherwise set
forth in the Plan, shares will be purchased for me automatically on the Purchase
Date of each Offering Period unless I otherwise withdraw from the Plan by giving
written notice to the Company for such purpose.

         4. I understand that I may discontinue at any time prior to the
Purchase Date my participation in the Plan as provided in Section 10 of the
Plan. I also understand that I can decrease the rate of my Contributions on one
occasion only during any Offering Period by completing and filing a new
Subscription Agreement with such decrease taking effect as of the beginning of
the calendar quarter following the date of filing of the new Subscription
Agreement. Further, I may change the rate of deductions for future Offering
Periods by filing a new Subscription Agreement, and any such change will be
effective as of the beginning of the next Offering Period. In addition, I
acknowledge that, unless I discontinue my participation in the Plan as provided
in Section 10 of the Plan, my election will continue to be effective for each
successive Offering Period.

         5. I have received a copy of the Company's most recent description of
the Plan and a copy of the complete "CONNETICS CORPORATION 1995 Employee Stock
Purchase Plan." I understand that my participation in the Plan is in all
respects subject to the terms of the Plan.

         6. Shares purchased for me under the Plan should be issued in the
name(s) of (name of employee or employee and spouse only):

                                            ------------------------------------

                                            ------------------------------------

         7. In the event of my death, I hereby designate the following as my
beneficiary(ies) to receive all payments and shares due to me under the Plan:




                                      -28-
<PAGE>   11

NAME:  (Please print)                      _____________________________________
                                            (First)       (Middle)        (Last)

____________________                       _____________________________________
(Relationship)                              (Address)

                                           _____________________________________

         8. I understand that if I dispose of any shares received by me pursuant
to the Plan within 2 years after the Offering Date (the first day of the
Offering Period during which I purchased such shares) or within 1 year after the
Purchase Date, I will be treated for federal income tax purposes as having
received ordinary compensation income at the time of such disposition in an
amount equal to the excess of the fair market value of the shares on the
Purchase Date over the price which I paid for the shares, regardless of whether
I disposed of the shares at a price less than their fair market value at the
Purchase Date. The remainder of the gain or loss, if any, recognized on such
disposition will be treated as capital gain or loss.

                  I hereby agree to notify the Company in writing within 30 days
after the date of any such disposition, and I will make adequate provision for
federal, state or other tax withholding obligations, if any, which arise upon
the disposition of the Common Stock. The Company may, but will not be obligated
to, withhold from my compensation the amount necessary to meet any applicable
withholding obligation including any withholding necessary to make available to
the Company any tax deductions or benefits attributable to the sale or early
disposition of Common Stock by me.

         9. If I dispose of such shares at any time after expiration of the
2-year and 1-year holding periods, I understand that I will be treated for
federal income tax purposes as having received compensation income only to the
extent of an amount equal to the lesser of (1) the excess of the fair market
value of the shares at the time of such disposition over the purchase price
which I paid for the shares under the option, or (2) 15% of the fair market
value of the shares on the Offering Date. The remainder of the gain or loss, if
any, recognized on such disposition will be treated as capital gain or loss.

         I understand that this tax summary is only a summary and is subject to
change. I further understand that I should consult a tax advisor concerning the
tax implications of the purchase and sale of stock under the Plan.

         10. I hereby agree to be bound by the terms of the Plan. The
effectiveness of this Subscription Agreement is dependent upon my eligibility to
participate in the Plan.



SIGNATURE: ______________________________

SOCIAL SECURITY #: ______________________

DATE: ___________________________________



SPOUSE'S SIGNATURE (necessary
if beneficiary is not spouse):





                                      -29-
<PAGE>   12
_________________________________________
(Signature)


_________________________________________
(Print name)






                                      -30-
<PAGE>   13
                              CONNETICS CORPORATION

                        1995 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL



         I, __________________________, hereby elect to withdraw my
participation in the CONNETICS CORPORATION 1995 Employee Stock Purchase Plan
(the "Plan") for the Offering Period _________. This withdrawal covers all
Contributions credited to my account and is effective on the date designated
below.

         I understand that all Contributions credited to my account will be paid
to me within ten (10) business days of receipt by the Company of this Notice of
Withdrawal and that my option for the current period will automatically
terminate, and that no further Contributions for the purchase of shares can be
made by me during the Offering Period.

         The undersigned further understands and agrees that he or she shall be
eligible to participate in succeeding offering periods only by delivering to the
Company a new Subscription Agreement.

         If the undersigned is an Officer or Director of CONNETICS CORPORATION
or other person subject to Section 16 of the Securities Exchange Act of 1934,
the undersigned further understands that under rules promulgated by the U.S.
Securities and Exchange Commission he or she may not re-enroll in the Plan for a
period of six (6) months after withdrawal.



Dated:___________________                  _____________________________________
                                           Signature of Employee


                                           _____________________________________
                                           Social Security Number






                                      -31-

<PAGE>   1
                                                                     Exhibit 4.6



                                    SCHEDULE


         Pursuant to Rule 12b-31 of the Securities Exchange Act of 1934, the
following documents, which are substantially identical in all material respects,
except as to the parties thereto, and, in one case, the date of execution, have
been omitted from this Exhibit 4.6:

         1. Stock Option Agreement between Connectics Corporation and Arthur
Eisen, dated as of March 28, 1996.

         2. Stock Option Agreement between Connectics Corporation and Phillip
Hanawalt, dated as of March 28, 1996.

         3. Stock Option Agreement between Connectics Corporation and Gerald
Nepom, dated as of March 28, 1996.

         4. Stock Option Agreement between Connectics Corporation and G. Kirk
Raab, dated as of January 28, 1997.








                                      -32-
<PAGE>   2
                          CONNECTIVE THERAPEUTICS, INC.

                             STOCK OPTION AGREEMENT


         1. Grant of Option. Connective Therapeutics, Inc., a Delaware
corporation (the "Company"), hereby grants to the Optionee (the "Optionee")
named in the attached Notice of Stock Option Grant (the "Notice"), an option
(the "Option") to purchase a total number of shares of Common Stock (the
"Shares") set forth in the Notice, at the Exercise Price Per Share set forth in
the Notice subject to the terms, definitions and provisions of this agreement
and to the extent necessary or appropriate or necessary for the interpretation
of this Agreement the Company's 1994 Stock Plan (the "Plan") adopted by the
Company, which is incorporated herein by reference notwithstanding that this
Option is not granted under the Plan. Unless otherwise defined herein, the terms
defined in the Plan shall have the same defined meanings as applied to this
Option.

                  If designated an Incentive Stock Option, this Option is
intended to qualify as an Incentive Stock Option as defined in Section 422 of
the Internal Revenue Code (the "Code").

         2. Exercise of Option. This Option shall be exercisable during its term
in accordance with the Vesting Schedule set out in the Notice and with the
provisions of Section 9 of the Plan as follows:

            (i) Right to Exercise.

                (a) This Option may not be exercised for a fraction of a share.

                (b) In the event of Optionee's death or disability, or other
termination of Optionee's consulting relationship or employment ("Continuous
Status"), the exercisability of the Option is governed by Sections 6, 7 and 8
below, subject to the limitation contained in subsection 2(i)(c).

                (c) In no event may this Option be exercised after the date of
expiration of the Term of this Option as set forth in the Notice.

            (ii) Method of Exercise. This Option shall be exercisable by written
notice (in the form attached as Exhibit A) which shall state the election to
exercise the Option, the number of shares of Common Stock in respect of which
the Option is being exercised (the "Shares Exercised"), and such other
representations and agreements as to the Optionee's investment intent with
respect to such Shares Exercised as may be required by the Company pursuant to
the provisions of the Plan. Such written notice shall be signed by the Optionee
and shall be delivered in person or by certified mail to the Secretary or
Assistant Secretary of the Company. The written notice shall be accompanied by
payment in the amount of the Shares Exercised times the Exercise Price Per Share
(the "Exercise Price"). Exercise of this Option shall be deemed to




                                      -33-
<PAGE>   3
be effective (the "Effective Date") upon receipt by the Company of such written
notice accompanied by the Exercise Price.

                 No stock certificate will be issued pursuant to the exercise of
an Option unless such issuance and such exercise shall be required to comply
with all relevant provisions of law and the requirements of any stock exchange
upon which the Shares may then be listed. Assuming such compliance, for income
tax purposes the Shares Exercised shall be considered issued to the Optionee on
the Effective Date on which the Option is exercised with respect thereto.

         3. Optionee's Representations. In the event the Shares purchasable
pursuant to the exercise of this Option have not been registered under the
Securities Act of 1933, as amended, at the time this Option is exercised,
Optionee shall, if required by the Company, concurrently with the exercise of
all or any portion of this Option, deliver to the Company his or her Investment
Representation Statement in the form attached hereto as Exhibit B, and shall
have read the applicable rules of the Commissioner of Corporations attached to
such Investment Representation Statement.

         4. Method of Payment. Payment of the Exercise Price shall be by any of
the following, or a combination thereof, at the election of the Optionee:

            (i) cash; or

            (ii) check; or

            (iii) surrender of other shares of Common Stock of the Company which
(A) in the case of Shares acquired pursuant to the exercise of a Company option,
have been owned by the Optionee for more than six (6) months on the date of
surrender, and (B) have a fair market value on the date of surrender equal to
the Exercise Price; or

            (iv) delivery of a properly executed exercise notice together with
such other documentation as the Administrator of the Plan and any broker
assisting in such exercise, if applicable, shall require to effect an exercise
of the Option and delivery to the Company of the sale or loan proceeds required
to pay the exercise price.

         5. Restrictions on Exercise. This Option may not be exercised if the
issuance of such Shares upon such exercise or the method of payment of
consideration for such shares would constitute a violation of any applicable
federal or state securities or other law or regulation, including any rule under
Part 207 of Title 12 of the Code of Federal Regulations ("Regulation G") as
promulgated by the Federal Reserve Board. As a condition to the exercise of this
Option, the Company may require Optionee to make any representation and warranty
to the Company as may be required by any applicable law or regulation.

         6. Termination of Relationship. In the event of termination of
Optionee's Continuous Status, Optionee may, to the extent otherwise so entitled
at the date of such




                                      -34-
<PAGE>   4
termination (the "Termination Date"), exercise this Option during the
Termination Period set out in the Notice of Grant. To the extent that Optionee
was not entitled to exercise this Option at the date of such termination, or if
Optionee does not exercise this Option within the time specified herein, the
Option shall terminate.

         7. Disability of Optionee.

            (a) Notwithstanding the provisions of Section 6 above, in the event
of termination of Optionee's Continuous Status as a result of his or her total
and permanent disability (within the meaning of Section 22(e)(3) of the Code),
Optionee may, but only within twelve (12) months from the date of such
termination (but in no event later than the Expiration Date of the Term of such
Option as set forth in Section 10 below), exercise the Option to the extent
otherwise entitled to exercise it at the date of such termination. To the extent
that Optionee was not entitled to exercise the Option at such date of
termination, or if Optionee does not exercise such Option to the extent so
entitled within the time specified herein, the Option shall terminate.

            (b) In the event of termination of an Optionee's Continuous Status
as a result of a disability which does not fall within the meaning of total and
permanent disability (as set forth in Section 22(e)(3) of the Code), Optionee
may, but only within six (6) months from the date of such termination (but in no
event later than the Expiration Date of the Term of such Option as set forth in
Section 10 below), exercise the Option to the extent otherwise entitled to
exercise it at the date of such termination. However, to the extent that such
Optionee fails to exercise an Option which is an Incentive Stock Option ("ISO")
(within the meaning of Section 422 of the Code) within three (3) months of such
date of termination, the Option will not qualify for ISO treatment under the
Code. To the extent that Optionee was not entitled to exercise the Option at
such date of termination, or if Optionee does not exercise such Option to the
extent so entitled within six months (6) from such date of termination, the
Option shall terminate.

         8. Death of Optionee. In the event of the death of Optionee, the Option
may be exercised at any time within twelve (12) months following the date of
death (but in no event later than the Expiration Date of the Term of this Option
as set forth in Section 10 below), by Optionee's estate or by a person who
acquired the right to exercise the Option by bequest or inheritance, but only to
the extent the Optionee could exercise the Option at the date of death.

         9. Non-Transferability of Option. This Option may not be transferred in
any manner otherwise than by will or by the laws of descent or distribution and
may be exercised during the lifetime of Optionee only by Optionee. The terms of
this Option shall be binding upon the executors, administrators, heirs,
successors and assigns of the Optionee.

         10. Term of Option. This Option may be exercised only within the Term
set out in the Notice, and may be exercised during such term only in accordance
with the Plan and the terms of this Option. The limitations set out in Section 7
of the Plan regarding Options designated as Incentive Stock Options and Options
granted to more than ten percent (10%) stockholders shall apply to this Option.




                                      -35-
<PAGE>   5
         11. Taxation Upon Exercise of Option. Optionee understands that, upon
exercising a nonstatutory Option, he or she will recognize income for tax
purposes in an amount equal to the excess of the then fair market value of the
Shares over the exercise price. However, the timing of this income recognition
may be deferred for up to six months if Optionee is subject to Section 16 of the
Securities Exchange Act of 1934, as amended (the "Exchange Act"). If the
Optionee is an employee, the Company will be required to withhold from
Optionee's compensation, or collect from Optionee and pay to the applicable
taxing authorities an amount equal to a percentage of this compensation income.
Additionally, the Optionee may at some point be required to satisfy tax
withholding obligations with respect to the disqualifying disposition of an
Incentive Stock Option. The Optionee shall satisfy his or her tax withholding
obligation arising upon the exercise of this Option by one or some combination
of the following methods: (i) by cash payment, or (ii) out of Optionee's current
compensation, or (iii) if permitted by the Administrator, in its discretion, by
surrendering to the Company Shares which (a) in the case of Shares previously
acquired from the Company, have been owned by the Optionee for more than six
months on the date of surrender, and (b) have a fair market value on the date of
surrender equal to or less than Optionee's marginal tax rate times the ordinary
income recognized, (iv) by electing to have the Company withhold from the Shares
to be issued upon exercise of the Option that number of Shares having a fair
market value equal to the amount required to be withheld. For this purpose, the
fair market value of the Shares to be withheld shall be determined on the date
that the amount of tax to be withheld is to be determined (the "Tax Date").

             If the Optionee is subject to Section 16 of the Exchange Act (an
"Insider"), any surrender of previously owned Shares to satisfy tax withholding
obligations arising upon exercise of this Option must comply with the applicable
provisions of Rule 16b-3 promulgated under the Exchange Act ("Rule 16b-3") and
shall be subject to such additional conditions or restrictions as may be
required thereunder to qualify for the maximum exemption from Section 16 of the
Exchange Act with respect to Plan transactions.

             All elections by an Optionee to have Shares withheld to satisfy tax
withholding obligations shall be made in writing in a form acceptable to the
Administrator and shall be subject to the following restrictions:

             (1) the election must be made on or prior to the applicable Tax
Date;

             (2) once made, the election shall be irrevocable as to the
particular Shares of the Option as to which the election is made;

             (3) all elections shall be subject to the consent or disapproval of
the Administrator;

             (4) if the Optionee is an Insider, the election must comply with
the applicable provisions of Rule 16b-3 and shall be subject to such additional
conditions or restrictions as may be required thereunder to qualify for the
maximum exemption from Section 16 of the Exchange Act with respect to Plan
transactions.




                                      -36-
<PAGE>   6
         12. Tax Consequences. Set forth below is a brief summary as of the date
of this Option of some of the federal and California tax consequences of
exercise of this Option and disposition of the Shares. THIS SUMMARY IS
NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE.
OPTIONEE SHOULD CONSULT A TAX ADVISER BEFORE EXERCISING THIS OPTION OR DISPOSING
OF THE SHARES.

             (i) Exercise of ISO. If this Option qualifies as an ISO, there will
be no regular federal income tax liability or California income tax liability
upon the exercise of the Option, although the excess, if any, of the fair market
value of the Shares on the date of exercise over the Exercise Price will be
treated as an adjustment to the alternative minimum tax for federal tax purposes
and may subject the Optionee to the alternative minimum tax in the year of
exercise.

             (ii) Exercise of Nonstatutory Stock Option. If this Option does not
qualify as an ISO, there may be a regular federal income tax liability and a
California income tax liability upon the exercise of the Option. The Optionee
will be treated as having received compensation income (taxable at ordinary
income tax rates) equal to the excess, if any, of the fair market value of the
Shares on the date of exercise over the Exercise Price. If Optionee is an
employee, the Company will be required to withhold from Optionee's compensation
or collect from Optionee and pay to the applicable taxing authorities an amount
equal to a percentage of this compensation income at the time of exercise.

             (iii) Disposition of Shares. In the case of an NSO, if Shares are
held for at least one year, any gain realized on disposition of the Shares will
be treated as long-term capital gain for federal and California income tax
purposes. In the case of an ISO, if Shares transferred pursuant to the Option
are held for at least one year after exercise and are disposed of at least two
years after the Date of Grant, any gain realized on disposition of the Shares
will also be treated as long-term capital gain for federal and California income
tax purposes. If Shares purchased under an ISO are disposed of within such
one-year period or within two years after the Date of Grant, any gain realized
on such disposition will be treated as compensation income (taxable at ordinary
income rates) to the extent of the difference between the Exercise Price and the
lesser of (1) the fair market value of the Shares on the date of exercise, or
(2) the sale price of the Shares.

             (iv) Notice of Disqualifying Disposition of ISO Shares. If the
Option granted to Optionee herein is an ISO, and if Optionee sells or otherwise
disposes of any of the Shares acquired pursuant to the ISO on or before the
later of (1) the date two years after the Date of Grant, or (2) the date one
year after the date of exercise, the Optionee shall immediately notify the
Company in writing of such disposition. Optionee agrees that Optionee may be
subject to income tax withholding by the Company on the compensation income
recognized by the Optionee from the early disposition by payment in cash or out
of the current earnings paid to the Optionee or as otherwise provided in Section
11.





                                      -37-
<PAGE>   7
         13. Entire Agreement. The Plan and Notice are incorporated herein by
reference. This Agreement, the Plan and the Notice constitute the entire
agreement of the parties and supersede in their entirety all prior undertakings
and agreements of the Company and Optionee with respect to the subject matter
hereof, and is governed by California law except for its or any other
jurisdiction's body of law pertaining to choice of laws.

OPTIONEE REPRESENTS THAT HE OR SHE IS ACQUIRING THIS OPTION FOR HIS OR HER OWN
ACCOUNT FOR INVESTMENT PURPOSES ONLY AND NOT WITH THE VIEW TO OR IN CONNECTION
WITH THE RESALE OR DISTRIBUTION THEREOF. OPTIONEE FURTHER ACKNOWLEDGES THAT ANY
TRANSFER OR SALE OF THIS OPTION OR ANY SECURITY HEREUNDER MUST BE MADE IN
COMPLIANCE WITH ALL APPLICABLE FEDERAL AND STATE SECURITIES LAWS.


                                       CONNECTIVE THERAPEUTICS, INC.
                                       a Delaware corporation


                                       By: _____________________________________
                                               Thomas G. Wiggans
                                               President & CEO

OPTIONEE ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT TO THE
OPTION HEREOF IS EARNED ONLY BY CONTINUING CONSULTANCY OR EMPLOYMENT AT THE WILL
OF THE COMPANY (NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS OPTION OR
ACQUIRING SHARES HEREUNDER). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT
NOTHING IN THIS AGREEMENT, NOR IN THE COMPANY'S STOCK OPTION PLAN WHICH IS
INCORPORATED HEREIN BY REFERENCE, SHALL CONFER UPON OPTIONEE ANY RIGHT WITH
RESPECT TO CONTINUATION OF EMPLOYMENT OR CONSULTANCY BY THE COMPANY, NOR SHALL
IT INTERFERE IN ANY WAY WITH HIS OR HER RIGHT OR THE COMPANY'S RIGHT TO
TERMINATE HIS OR HER EMPLOYMENT OR CONSULTANCY AT ANY TIME, WITH OR WITHOUT
CAUSE.

Optionee acknowledges receipt of a copy of the Plan and represents that Optionee
is familiar with the terms and provisions thereof, and hereby accepts this
Option subject to all of the terms and provisions thereof. Optionee has reviewed
the Plan and this Option in their entirety, has had an opportunity to obtain the
advice of counsel prior to executing this Option and fully understands all
provisions of the Option. Optionee hereby agrees to accept as binding,
conclusive and final all decisions or interpretations of the Administrator upon
any questions arising under the Plan or this Option.


_______________________      _________________________     _____________________
  Optionee's Signature        Optionee's Printed Name              Date




                                      -38-
<PAGE>   8
                                    EXHIBIT A

                                 EXERCISE NOTICE

Connective Therapeutics, Inc.
3400 West Bayshore Road
Palo Alto, California 94303
Attn:  _________________

         1. Exercise of Option. Effective as of today, ___________, 19__, the
undersigned ("Optionee") hereby elects to exercise Optionee's option to purchase
_________ shares of the Common Stock (the "Shares" or the "Shares Exercised") of
Connective Therapeutics, Inc. (the "Company") under and pursuant to the Notice
of Stock Option Grant and the Stock Option Agreement dated _____________ (the
"Option Agreement").

         2. Representations of Optionee. Optionee acknowledges that Optionee has
received, read and understood the Company's 1994 Stock Plan, as amended (the
"Plan") and the Option Agreement and agrees to abide by and be bound by their
terms and conditions. Optionee represents that Optionee is purchasing the Shares
Exercised for Optionee's own account for investment and not with a view to, or
for sale in connection with, a distribution of any of such Shares.

         3. Compliance with Securities Laws. Optionee understands and
acknowledges that the Shares Exercised have not been registered under the
Securities Act of 1933, as amended (the "1933 Act"), and, notwithstanding any
other provision of the Option Agreement to the contrary, the exercise of any
rights to purchase any such Shares is expressly conditioned upon compliance with
the 1933 Act, all applicable state securities laws and all applicable
requirements of any stock exchange or over the counter market on which the
Company's Common Stock may be listed or traded at the time of exercise and
transfer. Optionee agrees to cooperate with the Company to ensure compliance
with such laws.

         4. Federal Restrictions on Transfer. Optionee understands that the
Shares Exercised have not been registered under the 1933 Act and therefore
cannot be resold and must be held indefinitely unless they are registered under
the 1933 Act or unless an exemption from such registration is available and that
the certificate(s) representing the Shares Exercised may bear a legend to that
effect. Optionee understands that the Company is under no obligation to register
the Shares Exercised and that an exemption may not be available or may not
permit Optionee to transfer such Shares in the amounts or at the times proposed
by Optionee. Specifically, Optionee has been advised that Rule 144 promulgated
under the 1933 Act, which permits certain resales of unregistered securities, is
not presently available with respect to the Shares Exercised and, in any event
requires that the Shares Exercised be paid for and then be held for at least two
years (and in some cases three years) before they may be resold under Rule 144.

         5. Rights as Shareholder. Until the stock certificate evidencing such
Shares Exercised is issued (as evidenced by the appropriate entry on the books
of the Company or of a




                                      -39-
<PAGE>   9
duly authorized transfer agent of the Company), no right to vote or receive
dividends or any other rights as a stockholder shall exist with respect to the
optioned Stock, notwithstanding the exercise of the Option. The Company, in
accordance with Section 2(ii) of the Option Agreement, shall issue (or cause to
be issued) such stock certificate promptly after the Option is exercised. No
adjustment will be made for a dividend or other right for which the record date
is prior to the date the stock certificate is issued, except as provided in
Section 12 of the Plan.

                  Optionee shall enjoy rights as a stockholder until such time
as Optionee disposes of the Shares Exercised or the Company and/or its
assignee(s) exercises the Right of First Refusal hereunder and delivers payment
for such Shares. Upon such exercise, Optionee shall forthwith cause the
certificate(s) evidencing the Shares so purchased to be surrendered to the
Company for transfer or cancellation upon delivery of payment thereafter, after
which transfer or cancellation, Optionee shall have no further rights as a
holder of the Shares.

         6. Tax Consultation. Optionee understands that Optionee may suffer
adverse tax consequences as a result of Optionee's purchase or disposition of
the Shares. Optionee represents that Optionee has consulted with any tax
consultants Optionee deems advisable in connection with the purchase or
disposition of the Shares and that Optionee is not relying on the Company for
any tax advice.

         7. Restrictive Legends and Stop-Transfer Orders.

            (a) Legends. Optionee understands and agrees that the Company shall
cause the legends set forth below or legends substantially equivalent thereto,
to be placed upon any certificate(s) evidencing ownership of the Shares together
with any other legends that may be required by state or federal securities laws:

            THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
            SECURITIES ACT OF 1933 (THE "ACT") AND MAY NOT BE OFFERED, SOLD OR
            OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL
            REGISTERED UNDER THE ACT OR, IN THE OPINION OF COUNSEL IN FORM AND
            SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH
            OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS IN COMPLIANCE
            THEREWITH.

            (b) Stop-Transfer Notices. Optionee agrees that, in order to ensure
compliance with the restrictions referred to herein, the Company may issue
appropriate "stop transfer" instructions to its transfer agent, if any, and
that, if the Company transfers its own securities, it may make appropriate
notations to the same effect in its own records.

            (c) Refusal to Transfer. The Company shall not be required (i) to
transfer on its books any Shares that have been sold or otherwise transferred in
violation of any of the provisions of this Agreement or (ii) to treat as owner
of such Shares or to accord the right to vote




                                      -40-
<PAGE>   10
or pay dividends to any purchaser or other transferee to whom such Shares shall
have been so transferred.

         8. Market Standoff Agreement. In connection with the initial public
offering of the Company's securities and upon request of the Company or the
underwriters managing any underwritten offering of the Company's securities,
Optionee hereby agrees not to sell, make any short sale of, loan, grant any
option for the purchase of, or otherwise dispose of any Shares (other than those
included in the registration) without the prior written consent of the Company
or such underwriters, as the case may be, for such period of time (not to exceed
180 days) from the effective date of such registration as may be requested by
the Company or such managing underwriters; provided, however, that the Optionee
need not so agree unless a majority of the Company's officers and directors and
a majority of the holders of at least 5% of the Company's outstanding securities
also agree to be similarly bound.

         9. Successors and Assigns. The Company may assign any of its rights
under this Agreement to single or multiple assignees, and this Agreement shall
inure to the benefit of the successors and assigns of the Company. Subject to
the restrictions on transfer herein set forth, this Agreement shall be binding
upon Optionee and his or her heirs, executors, administrators, successors and
assigns.

         10. Interpretation. Any dispute regarding the interpretation of this
Agreement shall be submitted by Optionee or by the Company forthwith to the
Company's Board of Directors or the committee thereof that administers the Plan,
which shall review such dispute at its next regular meeting. The resolution of
such a dispute by the Board or committee shall be final and binding on the
Company and on Optionee.

         11. Governing Law; Severability. This Agreement shall be governed by
and construed in accordance with the laws of the State of California excluding
its or any other jurisdiction's body of law pertaining to choice of law. Should
any provision of this Agreement be determined by a court of law to be illegal or
unenforceable, the other provisions shall nevertheless remain effective and
shall remain enforceable.

         12. Notices. Any notice required or permitted hereunder shall be given
in writing and shall be deemed effectively given upon personal delivery or upon
deposit in the United States mail by certified mail, with postage and fees
prepaid, addressed to the other party at its address as shown below beneath its
signature, or to such other address as such party may designate in writing from
time to time to the other party.

         13. Further Instruments. The parties agree to execute such further
instruments and to take such further action as may be reasonably necessary to
carry out the purposes and intent of this Agreement.

         14. Delivery of Payment. Optionee herewith delivers to the Company the
full Exercise Price for the Shares.




                                      -41-
<PAGE>   11
         15. Entire Agreement. The Plan, the Notice and the Option Agreement are
incorporated herein by reference. This Agreement, the Plan, the Notice and the
Option Agreement constitute the entire agreement of the parties and supersede in
their entirety all prior undertakings and agreements of the Company and Optionee
with respect to the subject matter hereof.


Submitted by:                          Accepted by:

OPTIONEE:                              CONNECTIVE THERAPEUTICS, INC.


__________________________________     By: _____________________________________
Signature
                                       Its: ____________________________________
__________________________________
Social Security or Tax ID No.

Address: _________________________     Address:  3400 West Bayshore Road
                                                 Palo Alto, California  94303
__________________________________                

__________________________________                





                                      -42-
<PAGE>   12
                                    EXHIBIT B

                       INVESTMENT REPRESENTATION STATEMENT

OPTIONEE :

COMPANY  :        CONNECTIVE THERAPEUTICS, INC.

SECURITY :        COMMON STOCK

AMOUNT   :

DATE     :


In connection with the purchase of the above-listed Securities, I, the Optionee,
represent to the Company the following:

            (a) I am aware of the Company's business affairs and financial
condition, and have acquired sufficient information about the Company to reach
an informed and knowledgeable decision to acquire the Securities. I am
purchasing these Securities for my own account for investment purposes only and
not with a view to, or for the resale in connection with, any "distribution"
thereof for purposes of the Securities Act of 1933, as amended (the "Securities
Act").

            (b) I understand that the Securities have not been registered under
the Securities Act in reliance upon a specific exemption therefrom, which
exemption depends upon, among other things, the bona fide nature of my
investment intent as expressed herein. In this connection, I understand that, in
the view of the Securities and Exchange Commission (the "SEC"), the statutory
basis for such exemption may be unavailable if my representation was predicated
solely upon a present intention to hold these Securities for the minimum capital
gains period specified under tax statutes, for a deferred sale, for or until an
increase or decrease in the market price of the Securities, or for a period of
one year or any other fixed period in the future.

            (c) I further understand that the Securities must be held
indefinitely unless subsequently registered under the Securities Act or unless
an exemption from registration is otherwise available. Moreover, I understand
that the Company is under no obligation to register the Securities. In addition,
I understand that the certificate evidencing the Securities will be imprinted
with a legend which prohibits the transfer of the Securities unless they are
registered or such registration is not required in the opinion of counsel for
the Company.

            (d) I am familiar with the provisions of Rule 701 and Rule 144, each
promulgated under the Securities Act, which, in substance, permit limited public
resale of "restricted securities" acquired, directly or indirectly, from the
issuer thereof, in a non-public





                                      -43-
<PAGE>   13
offering subject to the satisfaction of certain conditions. Rule 701 provides
that if the issuer qualifies under Rule 701 at the time of issuance of the
Securities, such issuance will be exempt from registration under the Securities
Act. In the event the Company later becomes subject to the reporting
requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934,
ninety (90) days thereafter the securities exempt under Rule 701 may be resold,
subject to the satisfaction of certain of the conditions specified by Rule 144,
including among other things: (1) the sale being made through a broker in an
unsolicited "broker's transaction" or in transactions directly with a market
maker (as said term is defined under the Securities Exchange Act of 1934); and,
in the case of an affiliate, (2) the availability of certain public information
about the Company, and the amount of securities being sold during any three
month period not exceeding the limitations specified in Rule 144(e), if
applicable. Notwithstanding this paragraph (d), I acknowledge and agree to the
restrictions set forth in paragraph (e) hereof.

                In the event that the Company does not qualify under Rule 701 at
the time of issuance of the Securities, then the Securities may be resold in
certain limited circumstances subject to the provisions of Rule 144, which
requires among other things: (1) the availability of certain public information
about the Company, (2) the resale occurring not less than two years after the
party has purchased, and made full payment for, within the meaning of Rule 144,
the securities to be sold; and, in the case of an affiliate, or of a
non-affiliate who has held the securities less than three years, (3) the sale
being made through a broker in an unsolicited "broker's transaction" or in
transactions directly with a market maker (as said term is defined under the
Securities Exchange Act of 1934) and the amount of securities being sold during
any three month period not exceeding the specified limitations stated therein,
if applicable.

            (e) I further understand that in the event all of the applicable
requirements of Rule 144 or Rule 701 are not satisfied, registration under the
Securities Act, compliance with Regulation A, or some other registration
exemption will be required; and that, notwithstanding the fact that Rule 144 and
Rule 701 are not exclusive, the Staff of the SEC has expressed its opinion that
persons proposing to sell private placement securities other than in a
registered offering and otherwise than pursuant to Rule 144 or Rule 701 will
have a substantial burden of proof in establishing that an exemption from
registration is available for such offers or sales, and that such persons and
their respective brokers who participate in such transactions do so at their own
risk.

            (f) I understand that the certificate evidencing the Securities may
be imprinted with a legend which prohibits the transfer of the Securities
without the consent of the Commissioner of Corporations of California. I have
read the applicable Commissioner's Rules with respect to such restriction, a
copy of which is attached.



                                           Signature of Optionee:


                                           _____________________________________






                                      -44-

<PAGE>   1
                                                                     EXHIBIT 4.7



                          CONNECTIVE THERAPEUTICS, INC.

                          NOTICE OF STOCK OPTION GRANT


You (the "Optionee") have been granted an option (the "Option") to purchase
Common Stock of Connective Therapeutics, Inc. (the "Company") as follows:

         Optionee's Name:                   Arthur Z. Eisen

         Date of Grant:                     March 28, 1996

         Exercise Price Per Share:          $0.45

         Total Number of Shares Granted:    4,496

         Total Price of Shares Granted:     $2,023.20

         Type of Option:                    Nonstatutory Stock Option

         Term/Expiration Date:              March 28, 2006

         Vesting Commencement Date:         July 21, 1994

         Vesting Schedule:                  1/8th of the Total Number of Shares
                                            Granted shall vest on the six (6)
                                            month anniversary of the Vesting
                                            Commencement Date. Thereafter, while
                                            Optionee remains an employee of or
                                            consultant to the Company, 1/48th of
                                            the Total Number of Shares Granted
                                            shall vest on each monthly
                                            anniversary of the Vesting
                                            Commencement Date, until the Total
                                            Number of Shares Granted is fully
                                            vested.

         Termination                        Period: This Option (to the extent
                                            vested and not previously exercised)
                                            may be exercised for three months (3
                                            months maximum for ISO's) after
                                            termination of employment or
                                            consulting relationship except as
                                            provided in Sections 7 and 8 of the
                                            Stock Option Agreement (but in no
                                            event later than the Expiration
                                            Date).

By your signature and the signature of the Company's representative below, you
and the Company agree that this option is granted under and governed by the
terms and conditions of the Stock Option Agreement, attached and made a part of
this document.


OPTIONEE                                    CONNECTIVE THERAPEUTICS, INC.


  /s/ Arthur Z. Eisen                       By:  /s/ Thomas G. Wiggans
_____________________________                   ________________________________
      Arthur Z. Eisen                                Thomas G. Wiggans
                                                     President & CEO






                                      -45-

<PAGE>   1
                                                                     EXHIBIT 4.8



                          CONNECTIVE THERAPEUTICS, INC.

                          NOTICE OF STOCK OPTION GRANT


You (the "Optionee") have been granted an option (the "Option") to purchase
Common Stock of Connective Therapeutics, Inc. (the "Company") as follows:

         Optionee's Name:                   Phillip C. Hanawalt

         Date of Grant:                     March 28, 1996

         Exercise Price Per Share:          $0.45

         Total Number of Shares Granted:    4,496

         Total Price of Shares Granted:     $2,023.20

         Type of Option:                    Nonstatutory Stock Option

         Term/Expiration Date:              March 28, 2006

         Vesting Commencement Date:         July 15, 1994

         Vesting Schedule:                  1/8th of the Total Number of Shares
                                            Granted shall vest on the six (6)
                                            month anniversary of the Vesting
                                            Commencement Date. Thereafter, while
                                            Optionee remains an employee of or
                                            consultant to the Company, 1/48th of
                                            the Total Number of Shares Granted
                                            shall vest on each monthly
                                            anniversary of the Vesting
                                            Commencement Date, until the Total
                                            Number of Shares Granted is fully
                                            vested.

         Termination                        Period: This Option (to the extent
                                            vested and not previously exercised)
                                            may be exercised for three months (3
                                            months maximum for ISO's) after
                                            termination of employment or
                                            consulting relationship except as
                                            provided in Sections 7 and 8 of the
                                            Stock Option Agreement (but in no
                                            event later than the Expiration
                                            Date).

By your signature and the signature of the Company's representative below, you
and the Company agree that this option is granted under and governed by the
terms and conditions of the Stock Option Agreement, attached and made a part of
this document.


OPTIONEE                                    CONNECTIVE THERAPEUTICS, INC.


  /s/ Phillip C. Hanawalt                   By:  /s/ Thomas G. Wiggans
_____________________________                   ________________________________
      Phillip C. Hanawalt                            Thomas G. Wiggans
                                                     President & CEO





                                      -46-

<PAGE>   1
                                                                     EXHIBIT 4.9



                          CONNECTIVE THERAPEUTICS, INC.

                          NOTICE OF STOCK OPTION GRANT


You (the "Optionee") have been granted an option (the "Option") to purchase
Common Stock of Connective Therapeutics, Inc. (the "Company") as follows:

         Optionee's Name:                   Gerald T. Nepom

         Date of Grant:                     March 28, 1996

         Exercise Price Per Share:          $0.45

         Total Number of Shares Granted:    4,496

         Total Price of Shares Granted:     $2,023.20

         Type of Option:                    Nonstatutory Stock Option

         Term/Expiration Date:              March 28, 2006

         Vesting Commencement Date:         July 19, 1994

         Vesting Schedule:                  1/8th of the Total Number of Shares
                                            Granted shall vest on the six (6)
                                            month anniversary of the Vesting
                                            Commencement Date. Thereafter, while
                                            Optionee remains an employee of or
                                            consultant to the Company, 1/48th of
                                            the Total Number of Shares Granted
                                            shall vest on each monthly
                                            anniversary of the Vesting
                                            Commencement Date, until the Total
                                            Number of Shares Granted is fully
                                            vested.

         Termination                        Period: This Option (to the extent
                                            vested and not previously exercised)
                                            may be exercised for three months (3
                                            months maximum for ISO's) after
                                            termination of employment or
                                            consulting relationship except as
                                            provided in Sections 7 and 8 of the
                                            Stock Option Agreement (but in no
                                            event later than the Expiration
                                            Date).

By your signature and the signature of the Company's representative below, you
and the Company agree that this option is granted under and governed by the
terms and conditions of the Stock Option Agreement, attached and made a part of
this document.


OPTIONEE                                    CONNECTIVE THERAPEUTICS, INC.


  /s/ Gerald T. Nepom                       By:  /s/ Thomas G. Wiggans
_____________________________                   ________________________________
  Gerald T. Nepom                                    Thomas G. Wiggans
                                                     President & CEO





                                      -47-

<PAGE>   1
                                                                    EXHIBIT 4.10



                          CONNECTIVE THERAPEUTICS, INC.

                          NOTICE OF STOCK OPTION GRANT


You (the above-identified "Optionee") have been granted an option (the "Option")
to purchase Common Stock of Connective Therapeutics, Inc. (the "Company") as
follows:


         Optionee's Name:                   G. Kirk Raab

         Date of Grant:                     January 28, 1997

         Exercise Price Per Share:          $7.125

         Total Number of Shares Granted:    30,000

         Total Price of Shares Granted:     $213,750.00

         Type of Option:                    Nonstatutory Stock Option

         Term/Expiration Date:              January 28, 2007

         Vesting Commencement Date:         January 28, 1998

         Vesting Schedule:                  1/4th of the Total Number of Shares
                                            Granted shall vest on the twelve
                                            (12) month anniversary of the
                                            Vesting Commencement Date.
                                            Thereafter, while Optionee remains
                                            an employee of or consultant to the
                                            Company, 1/16th of the Total Number
                                            of Shares Granted shall vest on each
                                            quarter, until the Total Number of
                                            Shares Granted is fully vested.

         Termination Period:                This Option (to the extent vested
                                            and not previously exercised) may be
                                            exercised for three months (3 months
                                            maximum for ISO's) after termination
                                            of employment or consulting
                                            relationship except as provided in
                                            Sections 7 and 8 of the Stock Option
                                            Agreement (but in no event later
                                            than the Expiration Date).

By your signature and the signature of the Company's representative below, you
and the Company agree that this option is granted under and governed by the
terms and conditions of the Stock Option Agreement, attached and made a part of
this document.


OPTIONEE                                    CONNECTIVE THERAPEUTICS, INC.


  /s/ G. Kirk Raab                          By:  /s/ Thomas G. Wiggans
_____________________________                   ________________________________
  G. Kirk Raab                                       Thomas G. Wiggans
                                                     President & CEO





                                      -48-

<PAGE>   1
                                   EXHIBIT 5.1

                               OPINION OF COUNSEL

                                  June 30, 1997



Connectics Corporation
3400 W. Bayshore Road
Palo Alto, CA  94303

         REGISTRATION STATEMENT ON FORM S-8

Ladies and Gentlemen:

         We have examined the Registration Statement on Form S-8 to be filed by
you with the Securities and Exchange Commission on or about June 30, 1997 (the
"Registration Statement") in connection with the registration under the
Securities Act of 1933, as amended (the "Act") of a total of an additional
543,488 shares of your Common Stock (the "Shares"). Of these shares, 500,000
have been reserved for issuance under the 1994 Stock Plan, as amended (the
"Plan"). The remaining 43,488 shares were granted outside of the Plan pursuant
to other employee benefit plans, as that term is defined in Rule 405 of the Act.
As your legal counsel, we have examined the proceedings taken and are familiar
with the proceedings proposed to be taken by you in connection with the sale and
issuance of the Shares being registered.

         It is our opinion that (i) the Shares under the Plan when issued and
sold in the manner referred to in the Plan and pursuant to the respective
agreement which accompanies each grant under the Plan and (ii) the Shares not
covered by the Plan, when issued and sold pursuant to the terms and conditions
of the respective agreements that contemplate the issuance and sale of such
Shares, will be legally and validly issued, fully paid and nonassessable.

         We consent to the use of this opinion as an exhibit to the Registration
Statement and further consent to the use of our name wherever it appears in the
Registration Statement and any amendments to it.

                                       Sincerely,

                                       VENTURE LAW GROUP

                                       /s/ Venture Law Group








                                      -49-

<PAGE>   1
                                                                    EXHIBIT 23.2




                CONSENT OF ERNST & YOUNG LLP INDEPENDENT AUDITORS

         We consent to the incorporation by reference in this Registration
Statement (Form S-8), pertaining to the 1995 Employee Stock Purchase Plan and
1994 Stock Plan of Connectics Corporation (formerly Connective Therapeutics,
Inc.) and to the incorporation by reference of our report dated January 13, 1997
with respect to the financial statements of Connectics Corporation included in
the its Annual Report (Form 10-K), as amended for the year ended December 31,
1996 filed with the Securities and Exchange Commission.



                                       ERNST & YOUNG LLP
                                       /s/ Ernst & Young LLP




Palo Alto
June 26, 1997







                                      -50-


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