CONNETICS CORP
S-8, 1999-08-13
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
         As filed with the Securities and Exchange Commission on August 13, 1999
                                                   Registration No. 333
================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                ----------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      under
                           THE SECURITIES ACT OF 1933

                                ----------------

                              CONNETICS CORPORATION
             (Exact name of Registrant as specified in its charter)

<TABLE>
<S>                                         <C>
          Delaware                                         94-3173928
 (State of incorporation)                   (I.R.S. Employer Identification No.)
</TABLE>
                             3400 West Bayshore Road
                               Palo Alto, CA 94303
                    (Address of principal executive offices)

                             -----------------------

                                 1994 Stock Plan
                           1995 Directors' Stock Plan
                          1998 Supplemental Stock Plan
                                 2000 Stock Plan

                             -----------------------

                                Thomas G. Wiggans
                      President and Chief Executive Officer
                              CONNETICS CORPORATION
                             3400 West Bayshore Road
                               Palo Alto, CA 94303
                                 (650) 843-2800
 (Name, address and telephone number, including area code, of agent for service)

                             -----------------------

               (Calculation of Registration Fee on following page)


<PAGE>   2
<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------------------------------------------
                         CALCULATION OF REGISTRATION FEE
                                                                     Proposed Maximum        Proposed Maximum
                                                 Maximum Amount     Offering Price Per      Aggregate Offering       Amount of
                                                     to be               Share(2)               Price (2)           Registration
     Title of Securities to be Registered        Registered(1)                                                          Fee
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                              <C>                   <C>                      <C>               <C>
   Common Stock, $0.001 par value
   To be issued under:

       1994 Stock Plan                           500,000 Shares        $6.532 (3)               $3,266,000            $907.95

       1995 Directors' Stock Plan                150,000 Shares        $6.532 (3)                 $979,800            $272.38

       1998 Supplemental Stock Plan              274,250 Shares        $5.724(4)                $1,564,807            $436.41

       2000 Stock Plan                           600,000 Shares        $6.532 (2)               $3,919,200            $1,089.54

- ------------------------------------------------------------------------------------------------------------------------------------

                  TOTAL                        1,524,250 Shares                                 $9,734,807            $2,706.28
</TABLE>

- -----------------
(1)  This Registration Statement shall also cover any additional shares of
     Common Stock which become issuable under any of the referenced plans being
     registered pursuant to this Registration Statement by reason of any stock
     dividend, stock split, recapitalization or any other similar transaction
     effected without the receipt of consideration, which results in an increase
     in the number of the Registrant's outstanding shares of Common Stock.

(2)  Estimated solely for the purpose of determining the registration fee.

(3)  Computed in accordance with Rule 457(h) and Rule 457(c) of the Securities
     Act. The estimated exercise price of $6.532 was computed in accordance with
     Rule 457(c) by averaging the high and low prices of the Company's Common
     Stock as reported on The Nasdaq National Market on July 30, 1999.

(4)  Computed in accordance with Rule 457(h) of the Securities Act, based on the
     weighted average exercise price of $5.724 per share covering options
     granted under the 1998 Supplemental Stock Plan.


                                       2

<PAGE>   3

                                     PART II
               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.

     The following documents filed with the Securities and Exchange Commission
(the "Commission") are incorporated by reference into this Registration
Statement:

     a.   The description of the Company's Common Stock set forth in the
          Company's Registration Statement on Form 8-A filed with the Commission
          on December 8, 1995, including any amendment thereto or report filed
          for the purpose of updating such description (File No. 0-27406).

     b.   The description of the Company's Preferred Share Purchase Rights set
          forth in the Company's Registration Statement on Form 8-A filed with
          the Commission on May 23, 1997, including any amendment thereto or
          report filed for the purpose of updating such description (File No.
          0-27406).

     c.   The Company's Registration Statement on Form S-8, effective May 31,
          1996, as amended June 30, 1997 and July 2, 1998 (File No. 333-04985).

     d.   The Company's Annual Report on Form 10-K for the fiscal year ended
          December 31, 1998, filed March 31, 1999 (File No. 0-27406).

     e.   The Company's Quarterly Report on Form 10-Q for the quarter ended
          March 31, 1999, filed May 13, 1999 (File No. 0-27406).

     f.   The Company's Quarterly Report on Form 10-Q for the quarter ended June
          30, 1999, filed August 11, 1999 (File No. 0-27406).

     All reports and other documents subsequently filed by the Registrant
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to
the filing of a post-effective amendment which indicates that all securities
offered hereby have been sold or which deregisters all securities then remaining
unsold, shall be deemed to be incorporated by reference into this Registration
Statement and to be part hereof from the date of filing such documents. Any
statement contained in a document incorporated by reference herein shall be
deemed to be modified or superseded for purposes hereof to the extent that a
statement contained herein (or in any other subsequently filed document which
also is incorporated by reference herein) modifies or supersedes such statement.
Any such statement so modified or superseded shall not be deemed to constitute a
part hereof, except as so modified or superseded.

Item 4. Description of Securities.

     Not applicable.

Item 5. Interests of Named Experts and Counsel.

     Certain legal matters with respect to the legality of the issuance of the
shares of Common Stock registered hereunder will be passed upon for the Company
by Wilson Sonsini Goodrich & Rosati, Professional Corporation, 650 Page Mill
Road, Palo Alto, California 94304.

Item 6. Indemnification of Officers and Directors.

     Section 145 of the Delaware General Corporation Law authorizes a court to
award, or a corporation's Board of Directors to grant, indemnity to directors
and officers in terms sufficiently broad to permit such indemnification under
certain circumstances for liabilities (including reimbursement for expenses
incurred)

                                       3

<PAGE>   4

arising under the Securities Act of 1933. Article IX of the Registrant's Amended
and Restated Certificate of Incorporation and Article VII, Section 6 of the
Registrant's Bylaws provide for indemnification of its directors, officers,
employees and other agents to the maximum extent permitted by law. In addition,
the Registrant has entered into Indemnification Agreements with its officers and
directors and maintains director and officer liability insurance.

Item 7. Exemption from Registration Claimed.

     Not applicable.

Item 8. Exhibits. See Index to Exhibits (page 7).

Item 9. Undertakings.

     The undersigned Registrant hereby undertakes:

     (1)  To file, during any period in which offers or sales are being made, a
post-effective amendment to this Registration Statement to include any material
information with respect to the plan of distribution not previously disclosed in
the Registration Statement or any material change to such information in the
Registration Statement.

     (2)  That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

     (3)  To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.

     (4)  That, for purposes of determining any liability under the Securities
Act of 1933, each filing of the Registrant's annual report pursuant to Section
13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where
applicable, each filing of an employee benefit plan's annual report pursuant to
Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by
reference in the Registration Statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the provisions referred to in Item 6 above or otherwise,
the Registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Securities Act of 1933 and is, therefore, unenforceable. In the event
that a claim for indemnification against such liabilities (other than the
payment by the Registrant of expenses incurred or paid by a director, officer or
controlling person of the Registrant in the successful defense of any action,
suit or proceeding) is asserted against the Registrant by such director, officer
or controlling person in connection with the securities being registered
hereunder, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act of 1933 and will be governed by the
final adjudication of such issue.

                                       4

<PAGE>   5

                                   SIGNATURES


     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Palo Alto, State of California.

                                   Connetics Corporation
                                   a Delaware corporation



                                   By: /s/ JOHN L. HIGGINS
                                      ------------------------------------------
                                      John L. Higgins
                                      Vice President, Finance and Administration
                                      and Chief Financial Officer

Date: August 12, 1999


                                POWER OF ATTORNEY

     KNOW ALL BY THESE PRESENTS, that each person whose signature appears below
constitutes and appoints Thomas G. Wiggans and John L. Higgins, jointly and
severally, his attorneys-in-fact and agents, each with the power of substitution
and resubstitution, for him and in his name, place or stead, in any and all
capacities, to sign any amendments to this Registration Statement on Form S-8,
and to file such amendments, together with exhibits and other documents in
connection therewith, with the Securities and Exchange Commission, granting to
each attorney-in-fact and agent, full power and authority to do and perform each
and every act and thing requisite and necessary to be done in and about the
premises, as fully as he or she might or could do in person, and ratifying and
confirming all that the attorney-in-facts and agents, or his substitute or
substitutes, may do or cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons in the
capacities and on the dates indicated:

<TABLE>
<CAPTION>
Signature                                                       Title                                         Date
- ---------                                                       -----                                         ----
<S>                                              <C>                                                    <C>
Principal Executive Officer:

/s/ THOMAS G. WIGGANS                            President, Chief Executive Officer                     August 11, 1999
- ------------------------------------                         and Director
Thomas G. Wiggans

Principal Financial and Accounting Officer:

/s/ JOHN L. HIGGINS                              Vice President, Finance and Administration and         August 11, 1999
- ------------------------------------                       Chief Financial Officer
John L. Higgins

Chairman of the Board:

/s/ G. KIRK RAAB                                                Director                                August 11, 1999
- ------------------------------------
G. Kirk Raab
</TABLE>

                                       5

<PAGE>   6

<TABLE>
<CAPTION>
Signature                                                       Title                                         Date
- ---------                                                       -----                                         ----
<S>                                              <C>                                                    <C>

Additional Directors:

/s/ Alexander E. Barkas                                       Director                                  August 11, 1999
- ------------------------------------
Alexander E. Barkas

/s/ Eugene A. Bauer                                           Director                                  August 11, 1999
- ------------------------------------
Eugene A. Bauer

/s/ Brian H. Dovey                                            Director                                  August 11, 1999
- ------------------------------------
Brian H. Dovey

/s/ John C. Kane                                              Director                                  August 11, 1999
- ------------------------------------
John C. Kane

/s/ Thomas D. Kiley                                           Director                                  August 11, 1999
- ------------------------------------
Thomas D. Kiley

/s/ Joseph J. Ruvane, Jr.                                     Director                                  August 11, 1999
- ------------------------------------
Joseph J. Ruvane, Jr.
</TABLE>


                                        6

<PAGE>   7

                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>
Exhibit
Number
- -------
<S>      <C>
  4.1       1994 Stock Plan, as amended, and form of Option Agreement

  4.2       1995 Directors' Stock Plan, as amended, and form of Option Agreement

  4.3 *     1998 Supplemental Stock Plan (previously filed as Exhibit 10.60 to the Company's
            Annual Report on Form 10-K for the fiscal year ended December 31, 1998)

  4.4       2000  Stock  Plan and form of Option  Agreement

  5.1       Opinion of Wilson Sonsini Goodrich & Rosati, Professional Corporation

 23.1       Consent of Wilson Sonsini Goodrich & Rosati, Professional Corporation (included in
            Exhibit 5.1)

 23.2       Consent of Ernst & Young LLP, Independent Auditors

 24.1       Power of Attorney (see page 5)
</TABLE>

*    Previously filed.

                                       7


<PAGE>   1
                                                                     EXHIBIT 4.1


                             CONNETICS CORPORATION

                                 1994 STOCK PLAN
                          (AS AMENDED THROUGH MAY 1999)


      1.    Purposes of the Plan. The purposes of this Stock Plan are to attract
and retain the best available personnel for positions of substantial
responsibility, to provide additional incentive to Employees and Consultants of
the Company and its Subsidiaries and to promote the success of the Company's
business. Options granted under the Plan may be Incentive Stock Options (as
defined under Section 422 of the Code) or Nonstatutory Stock Options, as
determined by the Administrator at the time of grant of an option and reflected
in the terms of the written option agreement. Stock purchase rights may also be
granted under the Plan.

      2.    Definitions. As used herein, the following definitions shall apply:

            (a)   "Administrator" means the Board or any of its Committees
appointed pursuant to SECTION 4 of the Plan.

            (b)   "Board" means the Board of Directors of the Company.

            (c)   "Code" means the Internal Revenue Code of 1986, as amended.

            (d)   "Committee" means the Committee appointed by the Board of
Directors in accordance with SECTION 4(a) of the Plan, if one is appointed.

            (e)   "Common Stock" means the Common Stock of the Company.

            (f)   "Company" means Connetics Corporation, a Delaware corporation.

            (g)   "Consultant" means any person, including an advisor, who is
engaged by the Company or any Parent or Subsidiary to render services and is
compensated for such services, and any director of the Company, whether
compensated for such services or not.

            (h)   "Continuous Status as an Employee or Consultant" means the
absence of any interruption or termination of service as an Employee or
Consultant. Continuous Status as an Employee or Consultant shall not be
considered interrupted in the case of sick leave, military leave, or any other
leave of absence approved by the Administrator, provided that such leave is for
a period of not more than ninety (90) days, unless reemployment upon the
expiration of such leave is guaranteed by contract or statute, or unless
provided otherwise pursuant to Company policy adopted from time to time, or in
the case of transfers between locations of the Company or between the Company,
its Subsidiaries or its successor. For purposes of this Plan, a change in status
from an Employee to a Consultant or from a Consultant to an Employee will not
constitute a termination of employment.

            (i)   "Director" means a member of the Board.


<PAGE>   2
            (j)   "Employee" means any person, including Named Executives,
Officers and Directors, employed by the Company or any Parent or Subsidiary of
the Company. The payment by the Company of a director's fee to a Director shall
not be sufficient to constitute "employment" of such Director by the Company.

            (k)   "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

            (l)   "Fair Market Value" means, as of any date, the value of Common
Stock determined as follows:

                  (i)   If the Common Stock is listed on any established stock
      exchange or a national market system including without limitation the
      National Market of the National Association of Securities Dealers, Inc.
      Automated Quotation ("Nasdaq") System, its Fair Market Value shall be the
      closing sales price for such stock as quoted on such system on the date of
      determination (or the closing bid, if no sales were reported on that day)
      as reported in The Wall Street Journal or such other source as the
      Administrator deems reliable;

                  (ii)  If the Common Stock is quoted on the Nasdaq System (but
      not on the National Market thereof) or regularly quoted by a recognized
      securities dealer but selling prices are not reported, its Fair Market
      Value shall be the mean between the high bid and low asked prices for the
      Common Stock or;

                  (iii) In the absence of an established market for the Common
      Stock, the Fair Market Value thereof shall be determined in good faith by
      the Administrator.

            (m)   "Incentive Stock Option" means an Option intended to qualify
as an incentive stock option within the meaning of Section 422 of the Code, as
designated in the applicable written option agreement.

            (n)   "Named Executive" means any individual who, on the last day of
the Company's fiscal year, is the chief executive officer of the Company (or is
acting in such capacity) or among the four highest compensated officers of the
Company (other than the chief executive officer). Such officer status shall be
determined pursuant to the executive compensation disclosure rules under the
Exchange Act.

            (o)   "Nonstatutory Stock Option" means an Option not intended to
qualify as an Incentive Stock Option, as designated in the applicable written
option agreement.

            (p)   "Officer" means a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.

            (q)   "Option" means a stock option granted pursuant to the Plan.

            (r)   "Optioned Stock" means the Common Stock subject to an Option
or a Stock Purchase Right.


                                      -2-
<PAGE>   3
            (s)   "Optionee" means an Employee or Consultant who receives an
Option or Stock Purchase Right.

            (t)   "Parent" means a "parent corporation", whether now or
hereafter existing, as defined in Section 424(e) of the Code.

            (u)   "Plan" means this 1994 Stock Plan.

            (v)   "Restricted Stock" means shares of Common Stock acquired
pursuant to a grant of a Stock Purchase Right under SECTION 11 below.

            (w)   "Rule 16b-3" means Rule 16b-3 promulgated under the Exchange
Act as the same may be amended from time to time, as any successor provision.

            (x)   "Share" means a share of the Common Stock, as adjusted in
accordance with SECTION 13 below.

            (y)   "Stock Purchase Right" means the right to purchase Common
Stock pursuant to SECTION 11 below.

            (z)   "Subsidiary" means a "subsidiary corporation", whether now or
hereafter existing, as defined in Section 424(f) of the Code.

      3.    Stock Subject to the Plan. Subject to the provisions of SECTION 13
of the Plan, the maximum aggregate number of shares which may be optioned and
sold under the Plan is 3,100,000 shares of Common Stock. The shares may be
authorized, but unissued, or reacquired Common Stock. If an Option should expire
or become unexercisable for any reason without having been exercised in full,
the unpurchased Shares which were subject thereto shall, unless the Plan shall
have been terminated, become available for future grant under the Plan.
Notwithstanding any other provision of the Plan, Shares issued under the Plan
and later repurchased by the Company shall not become available for future grant
or sale under the Plan.

      4.    Administration of the Plan.

            (a)   Composition of the Administrator.

                  (i)   Multiple Administrative Bodies. If permitted by Rule
      16b-3 and by the legal requirements relating to the administration of
      incentive stock option plans, if any, of the applicable securities laws
      and the Code (collectively the "Applicable Laws"), grants and sales under
      the Plan may (but need not) be made by different administrative bodies
      with respect to Directors, Officers who are not directors and Employees
      who are neither Directors nor Officers.

                  (ii)  Administration With Respect to Directors and Officers.
      With respect to grants of Options or Stock Purchase Rights to Employees or
      Consultants who are also Officers or Directors of the Company, grants or
      sales under the Plan shall be made by (A) the Board if the Board may make
      grants or sales under the Plan in compliance with Rule 16b-3 and Section
      162(m) of the


                                      -3-
<PAGE>   4
      Code as it applies so as to qualify grants of Options or Stock Purchase
      Rights to Named Executives as performance-based compensation, or (B) a
      Committee designated by the Board to make grants or sales under the Plan,
      which committee shall be constituted in such a manner as to permit grants
      or sales under the Plan to comply with Rule 16b-3, to qualify grants of
      Options or Stock Purchase Rights to Named Executives as performance-based
      compensation under Section 162(m) of the Code and otherwise so as to
      satisfy the Applicable Laws.

                  (iii) Administration With Respect to Other Persons. With
      respect to grants of Options or Stock Purchase Rights to Employees or
      Consultants who are neither Directors nor Officers of the Company, the
      Plan shall be administered by (A) the Board or (B) a committee designated
      by the Board, which committee shall be constituted in such a manner as to
      satisfy the Applicable Laws.

                  (iv)  General. If a Committee has been appointed pursuant to
      SUBSECTION (ii) or (iii) of this SECTION 4(a), such Committee shall
      continue to serve in its designated capacity until otherwise directed by
      the Board. From time to time the Board may increase the size of the
      Committee and appoint additional members thereof, remove members (with or
      without cause) and appoint new members in substitution therefor, fill
      vacancies, however caused, and remove all members of the Committee and
      thereafter directly administer the Plan, all to the extent permitted by
      the Applicable Laws and, in the case of a Committee appointed under
      SUBSECTION (ii) of this SECTION 4(a), to the extent permitted by Rule
      16b-3, and to the extent required under Section 162(m) of the Code to
      qualify grants of Options or Stock Purchase Rights to Named Executives as
      performance-based compensation.

            (b)   Powers of the Administrator. Subject to the provisions of the
Plan and in the case of a Committee, the specific duties delegated by the Board
to such Committee, and subject to the approval of any relevant authorities,
including the approval, if required, of any stock exchange upon which the Common
Stock is listed, the Administrator shall have the authority, in its discretion:

                  (i)   to determine the Fair Market Value of the Common Stock,
      in accordance with SECTION 2(l) of the Plan;

                  (ii)  to select the Consultants and Employees to whom Options
      and Stock Purchase Rights may from time to time be granted hereunder;

                  (iii) to determine whether and to what extent Options and
      Stock Purchase Rights or any combination thereof are granted hereunder;

                  (iv)  to determine the number of shares of Common Stock to be
      covered by each such award granted hereunder;

                  (v)   to approve forms of agreement for use under the Plan;


                                      -4-
<PAGE>   5
                  (vi)  to determine the terms and conditions, not inconsistent
      with the terms of the Plan, of any award granted hereunder;

                  (vii) to determine whether and under what circumstances an
      Option may be settled in cash under SUBSECTION 10(f) instead of Common
      Stock;

                  (viii) to reduce the exercise price of any Option to the then
      current Fair Market Value if the Fair Market Value of the Common Stock
      covered by such Option shall have declined since the date the Option was
      granted; and

                  (ix)  to determine the terms and restrictions applicable to
      Stock Purchase Rights and the Restricted Stock purchased by exercising
      such Stock Purchase Rights.

            (c)   Effect of Administrator's Decision. All decisions,
determinations and interpretations of the Administrator shall be final and
binding on all Optionees and any other holders of any Options or Stock Purchase
Rights.

      5.    Eligibility.

            (a)   Nonstatutory Stock Options and Stock Purchase Rights may be
granted to Employees and Consultants. Incentive Stock Options may be granted
only to Employees. An Employee or Consultant who has been granted an Option or
Stock Purchase Right may, if he is otherwise eligible, be granted additional
Options or Stock Purchase Rights.

            (b)   Each Option shall be designated in the written option
agreement as either an Incentive Stock Option or a Nonstatutory Stock Option.
However, notwithstanding such designations, to the extent that the aggregate
Fair Market Value of the Shares with respect to which Options designated as
Incentive Stock Options are exercisable for the first time by any Optionee
during any calendar year (under all plans of the Company or any Parent or
Subsidiary) exceeds $100,000, such excess Options shall be treated as
Nonstatutory Stock Options. For purposes of this section, Incentive Stock
Options shall be taken into account in the order in which they were granted, and
the Fair Market Value of the Shares shall be determined as of the time the
Option with respect to such Shares is granted.

            (c)   The Plan shall not confer upon any Optionee any right with
respect to continuation of employment or consulting relationship with the
Company, nor shall it interfere in any way with his or her right or the
Company's right to terminate his or her employment or consulting relationship at
any time, with or without cause.

      6.    Term of Plan. The Plan shall become effective upon the earlier to
occur of its adoption by the Board of Directors or its approval by the
shareholders of the Company as described in SECTION 21 of the Plan. It shall
continue in effect for a term of ten (10) years unless sooner terminated under
SECTION 17 of the Plan.

      7.    Term of Option. The term of each Option shall be the term stated in
the Option Agreement; provided, however, that in the case of an Incentive Stock
Option, the term shall be no more than ten (10) years from the date of grant
thereof or such shorter term as may be


                                      -5-
<PAGE>   6
provided in the Option Agreement. However, in the case of an Option
granted to an Optionee who, at the time the Option is granted, owns stock
representing more than ten percent (10%) of the voting power of all classes of
stock of the Company or any Parent or Subsidiary, the term of the Option shall
be five (5) years from the date of grant thereof or such shorter term as may be
provided in the Option Agreement.

      8.    Limitation on Grants to Employees. Subject to adjustment as provided
in this Plan, the maximum number of Shares which may be subject to Options or
Stock Purchase Rights granted to any one Employee under this Plan for any fiscal
year of the Company shall be 150,000.

      9.    Option Exercise Price and Consideration.

            (a)   The per Share exercise price for the Shares to be issued
pursuant to exercise of an Option shall be such price as is determined by the
Administrator, but shall be subject to the following:

                  (i)   In the case of an Incentive Stock Option

                        (A)   granted to an Employee who, at the time of the
            grant of such Incentive Stock Option, owns stock representing more
            than ten percent (10%) of the voting power of all classes of stock
            of the Company or any Parent or Subsidiary, the per Share exercise
            price shall be no less than 110% of the Fair Market Value per Share
            on the date of grant.

                        (B)   granted to any other Employee, the per Share
            exercise price shall be no less than 100% of the Fair Market Value
            per Share on the date of grant.

                  (ii)  In the case of a Nonstatutory Stock Option

                        (A)   granted to a person who, at the time of the grant
            of such Option, is a Named Executive of the Company, the per Share
            exercise price shall be no less than one hundred percent (100%) of
            the Fair market Value on the date of grant; or

                        (B)   granted to any person other than a Named
            Executive, the per Share exercise price shall be no less than 85% of
            the Fair Market Value per Share on the date of grant.

                  (iii) Notwithstanding anything to the contrary in SUBSECTIONS
      9(a)(i) or 9(a)(ii) above, in the case of an Option granted on or after
      the effective date of registration of any class of equity security of the
      Company pursuant to Section 12 of the Exchange Act and prior to six months
      after the termination of such registration, the per Share exercise price
      shall be no less than 100% of the Fair Market Value per Share on the date
      of grant.


                                      -6-
<PAGE>   7
            (b)   The consideration to be paid for the Shares to be issued upon
exercise of an Option, including the method of payment, shall be determined by
the Administrator (and, in the case of an Incentive Stock Option, shall be
determined at the time of grant) and may consist entirely of

                  (1)   cash,

                  (2)   check,

                  (3)   promissory note,

                  (4)   other Shares which (x) in the case of Shares acquired
      upon exercise of an Option either have been owned by the Optionee for more
      than six months on the date of surrender or were not acquired, directly or
      indirectly, from the Company, and (y) have a Fair Market Value on the date
      of surrender equal to the aggregate exercise price of the Shares as to
      which said Option shall be exercised,

                  (5)   authorization from the Company to retain from the total
      number of Shares as to which the Option is exercised that number of Shares
      having a Fair Market Value on the date of exercise equal to the exercise
      price for the total number of Shares as to which the Option is exercised,

                  (6)   delivery of a properly executed exercise notice together
      with such other documentation as the Administrator and the broker, if
      applicable, shall require to effect an exercise of the Option and delivery
      to the Company of the sale or loan proceeds required to pay the exercise
      price,

                  (7)   any combination of the foregoing methods of payment, or

                  (8)   such other consideration and method of payment for the
      issuance of Shares to the extent permitted under Applicable Laws. In
      making its determination as to the type of consideration to accept, the
      Board shall consider if acceptance of such consideration may be reasonably
      expected to benefit the Company.

      10.   Exercise of Option.

            (a)   Procedure for Exercise; Rights as a Shareholder.

                  (i)   Any Option granted hereunder shall be exercisable at
      such times and under such conditions as determined by the Administrator,
      including performance criteria with respect to the Company and/or the
      Optionee, and as shall be permissible under the terms of the Plan.

                  (ii)  An Option may not be exercised for a fraction of a
      Share.

                  (iii) An Option shall be deemed to be exercised when written
      notice of such exercise has been given to the Company in accordance with
      the terms of the Option by the person entitled to exercise the Option and
      full payment for the Shares with respect to which the Option is exercised
      has been received by


                                      -7-
<PAGE>   8
      the Company. Full payment may, as authorized by the Administrator, consist
      of any consideration and method of payment allowable under SECTION 9(b) of
      the Plan. Until the issuance (as evidenced by the appropriate entry on the
      books of the Company or of a duly authorized transfer agent of the
      Company) of the stock certificate evidencing such Shares, no right to vote
      or receive dividends or any other rights as a shareholder shall exist with
      respect to the Optioned Stock, notwithstanding the exercise of the Option.
      The Company shall issue (or cause to be issued) such stock certificate as
      promptly as practicable upon exercise of the Option. No adjustment will be
      made for a dividend or other right for which the record date is prior to
      the date the stock certificate is issued, except as provided in SECTION 14
      of the Plan.

                  (iv)  Exercise of an Option in any manner shall result in a
      decrease in the number of Shares which thereafter may be available, both
      for purposes of the Plan and for sale under the Option, by the number of
      Shares as to which the Option is exercised.

            (b)   Termination of Status as an Employee or Consultant. In the
event of termination of an Optionee's Continuous Status as an Employee or
Consultant, such Optionee may, but only within thirty (30) days (or such other
period of time, not exceeding three (3) months in the case of an Incentive Stock
Option or six (6) months in the case of a Nonstatutory Stock Option, as is
determined by the Administrator, with such determination in the case of an
Incentive Stock Option being made at the time of grant of the Option) after the
date of such termination (but in no event later than the date of expiration of
the term of such Option as set forth in the Option Agreement), exercise his or
her Option to the extent that he or she was entitled to exercise it at the date
of such termination. To the extent that the Optionee was not entitled to
exercise the Option at the date of such termination, or if the optionee does not
exercise such Option (which he or she was entitled to exercise) within the time
specified herein, the Option shall terminate.

            (c)   Disability of Optionee.

                  (i)   Notwithstanding the provisions of SECTION 9(b) above, in
      the event of termination of an Optionee's Continuous Status as an Employee
      or Consultant as a result of his or her total and permanent disability
      (within the meaning of Section 22(e)(3) of the Code), Optionee may, but
      only within twelve (12) months from the date of such termination (but in
      no event later than the expiration date of the term of such Option as set
      forth in the Option Agreement), exercise the Option to the extent
      otherwise entitled to exercise it at the date of such termination. To the
      extent that Optionee was not entitled to exercise the Option at the date
      of termination, or if Optionee does not exercise such Option to the extent
      so entitled within the time specified herein, the Option shall terminate.

                  (ii)  In the event of termination of an Optionee's Continuous
      Status as an Employee or Consultant as a result of a disability which does
      not fall within the meaning of total and permanent disability (as set
      forth in Section 22(e)(3) of the Code), Optionee may, but only within six
      (6) months from the date of such termination (but in no event later than
      the expiration date of the term of such Option as set forth in the Option
      Agreement), exercise the


                                      -8-
<PAGE>   9
      Option to the extent otherwise entitled to exercise it at the date of such
      termination. However, to the extent that such Optionee fails to exercise
      an Option which is an Incentive Stock Option within three (3) months of
      the date of such termination, the Option will not qualify for ISO
      treatment under the Code. To the extent that Optionee was not entitled to
      exercise the Option at the date of termination, or if Optionee does not
      exercise such Option to the extent so entitled within six months (6) from
      the date of termination, the Option shall terminate.

            (d)   Death of Optionee. In the event of the death of an Optionee
during the term of the Option who is at the time of death an Employee or
Consultant of the Company, the Option may be exercised, at any time within
twelve (12) months following the date of death (but in no event later than the
expiration date of the term of such Option as set forth in the Option
Agreement), by the Optionee's estate or by a person who acquired the right to
exercise the Option by bequest or inheritance, but only to the extent the
Optionee was entitled to exercise the Option at the date of death. To the extent
that Optionee was not entitled to exercise the Option at the date of
termination, or if Optionee does not exercise such Option to the extent so
entitled within the time specified herein, the Option shall terminate.

            (e)   Rule 16b-3. Options granted to persons subject to Section
16(b) of the Exchange Act must comply with Rule 16b-3 and shall contain such
additional conditions or restrictions as may be required thereunder to qualify
for the maximum exemption from Section 16 of the Exchange Act with respect to
Plan transactions.

            (f)   Buyout Provisions. The Administrator may at any time offer to
buy out for a payment in cash or Shares, an Option previously granted, based on
such terms and conditions as the Administrator shall establish and communicate
to the Optionee at the time that such offer is made.

      11.   Non-Transferability of Options. Option may not be sold, pledged,
assigned, hypothecated, transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution and may be exercised, during the
lifetime of the Optionee, only by the Optionee.

      12.   Stock Purchase Rights.

            (a)   Rights to Purchase. Stock Purchase Rights may be issued either
alone, in addition to, or in tandem with other awards granted under the Plan
and/or cash awards made outside of the Plan. After the Administrator determines
that it will offer Stock Purchase Rights under the Plan, it shall advise the
offeree in writing of the terms, conditions and restrictions related to the
offer, including the number of Shares that such person shall be entitled to
purchase, the price to be paid (which price shall not be less than 85% of the
Fair Market Value of the Shares as of the date of the offer or, in the case of a
shareholder owning ten percent (10%) or more of the Company's outstanding stock
or a person who is a Named Executive, 100% of the Fair Market Value of the
Shares as of the date of the offer), and the time within which such person must
accept such offer, which shall in no event exceed thirty (30) days from the date
upon which the Administrator made the determination to grant the Stock Purchase
Right. The offer shall be accepted by execution of a Restricted Stock purchase
agreement in the form determined


                                      -9-
<PAGE>   10
by the Administrator. Shares purchased pursuant to the grant of a Stock Purchase
Right shall be referred to herein as "Restricted Stock."

            (b)   Repurchase Option. Unless the Administrator determines
otherwise, the Restricted Stock purchase agreement shall grant the Company a
repurchase option exercisable upon the voluntary or involuntary termination of
the purchaser's employment with the Company for any reason (including death or
Disability). The purchase price for Shares repurchased pursuant to the
Restricted Stock purchase agreement shall be the original price paid by the
purchaser and may be paid by cancellation of any indebtedness of the purchaser
to the Company. The repurchase option shall lapse at such rate as the Board or
Committee may determine.

            (c)   Other Provisions. The Restricted Stock purchase agreement
shall contain such other terms, provisions and conditions not inconsistent with
the Plan as may be determined by the Administrator in its sole discretion. In
addition, the provisions of Restricted Stock purchase agreements need not be the
same with respect to each purchaser.

            (d)   Rights as a Shareholder. Once the Stock Purchase Right is
exercised, the purchaser shall have the rights equivalent to those of a
shareholder, and shall be a shareholder when his or her purchase is entered upon
the records of the duly authorized transfer agent of the Company. No adjustment
will be made for a dividend or other right for which the record date is prior to
the date the Stock Purchase Right is exercised, except as provided in SECTION 14
of the Plan.

      13.   Withholding Taxes. As a condition to the exercise of Options or the
purchase of Restricted Stock pursuant to awards granted hereunder, the Optionee
or purchaser shall make such arrangements as the Administrator may require for
the satisfaction of any federal, state, local or foreign withholding tax
obligations that may arise in connection with the exercise, receipt or vesting
of such award. The Company shall not be required to issue any Shares under the
Plan until such obligations are satisfied.

      14.   Stock Withholding to Satisfy Withholding Tax Obligations.

            (a)   At the discretion of the Administrator, Optionees may satisfy
withholding obligations as provided in this paragraph. When an Optionee incurs
tax liability in connection with an Option or Stock Purchase Right, which tax
liability is subject to tax withholding under applicable tax laws, and the
Optionee is obligated to pay the Company an amount required to be withheld under
applicable tax laws, the Optionee may satisfy the withholding tax obligation by
electing to have the Company withhold from the Shares to be issued upon exercise
of the Option, or the Shares to be issued in connection with the Stock Purchase
Right, if any, that number of Shares having a Fair Market Value equal to the
amount required to be withheld. The Fair Market Value of the Shares to be
withheld shall be determined on the date that the amount of tax to be withheld
is to be determined (the "Tax Date").

            (b)   Any surrender by an Officer or Director of previously owned
Shares to satisfy tax withholding obligations arising upon exercise of this
Option must comply with the applicable provisions of Rule 16b-3.


                                      -10-
<PAGE>   11
            (c)   All elections by an Optionee to have Shares withheld for this
purpose shall be made in writing in a form acceptable to the Administrator and
shall be subject to the following restrictions:

                  (i)   the election must be made on or prior to the applicable
      Tax Date;

                  (ii)  once made, the election shall be irrevocable as to the
      particular Shares of the Option or Stock Purchase Right as to which the
      election is made; and

                  (iii) all elections shall be subject to the consent or
      disapproval of the Administrator.

            (d)   In the event the election to have Shares withheld is made by
an Optionee and the Tax Date is deferred under Section 83 of the Code because no
election is filed under Section 83(b) of the Code, the Optionee shall receive
the full number of Shares with respect to which the Option or Stock Purchase
Right is exercised but such Optionee shall be unconditionally obligated to
tender back to the Company the proper number of Shares on the Tax Date.

      15.   Adjustments Upon Changes in Capitalization; Corporate Transaction.

            (a)   Changes in Capitalization. Subject to any required action by
the shareholders of the Company, the number of shares of Common Stock covered by
each outstanding Option or Stock Purchase Right, and the number of shares of
Common Stock which have been authorized for issuance under the Plan but as to
which no Options or Stock Purchase Rights have yet been granted or which have
been returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, as well as the price per share of Common Stock covered by each
such outstanding Option or Stock Purchase Right, shall be proportionately
adjusted for any increase or decrease in the number of issued shares of Common
Stock resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Common Stock, or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of consideration by the Company; provided, however, that conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or price of shares of Common Stock subject to an Option or Stock
Purchase Right.

            (b)   Corporate Transactions. In the event of a dissolution or
liquidation of the Company, the Option will terminate immediately prior to the
consummation of such action, unless otherwise provided by the Administrator. The
Administrator may, in the exercise of its sole discretion in such instances,
declare that any Option shall terminate as of a date fixed by the Administrator
and give each Optionee the right to exercise his or her Option as to all of the
Optioned Stock, including Shares as to which the Option would not otherwise be
exercisable. In the event of a proposed sale of all or substantially all of the
assets of the Company, the merger of

                                      -11-
<PAGE>   12
the Company with or into another corporation or any other capital reorganization
in which more than fifty percent (50%) of the shares of the Company entitled to
vote are exchanged, the Option shall be assumed or an equivalent option shall be
substituted by such successor corporation or a parent or subsidiary of such
successor corporation, unless the Administrator determines, in the exercise of
its sole discretion and in lieu of such assumption or substitution, that the
Optionee shall have the right to exercise the Option as to all of the Optioned
Stock, including Shares as to which the Option would not otherwise be
exercisable. If the Administrator makes an Option exercisable in lieu of
assumption or substitution in the event of a merger or sale of assets, the
Administrator shall notify the Optionee that the Option shall be exercisable for
a period of thirty (30) days from the date of such notice, and the Option will
terminate upon the expiration of such period.

      16.   Time of Granting Options and Stock Purchase Rights. The date of
grant of an Option or Stock Purchase Right shall, for all purposes, be the date
on which the Administrator makes the determination granting such Option or Stock
Purchase Right, or such other date as is determined by the Administrator;
provided however that in the case of any Incentive Stock Option, the grant date
shall be the later of the date on which the Administrator makes the
determination granting such Incentive Stock Option or the date of commencement
of the Optionee's employment relationship with the Company. Notice of the
determination shall be given to each Employee or Consultant to whom an Option or
Stock Purchase Right is so granted within a reasonable time after the date of
such grant.

      17.   Amendment and Termination of the Plan.

            (a)   Amendment and Termination. The Board may amend or terminate
the Plan from time to time in such respects as the Board may deem advisable;
provided, however, that the following revisions or amendments shall require
approval of the shareholders of the Company in the manner described in SECTION
20 of the Plan:

                  (i)   any increase in the number of Shares subject to the
      Plan, other than in connection with an adjustment under SECTION 15 above;

                  (ii)  any change in the designation of the class of persons
      eligible to be granted Options;

                  (iii) any change in the limitation on grants to employees as
      described in SECTION 8 of the Plan or other changes which would require
      shareholder approval to qualify options granted hereunder as
      performance-based compensation under Section 162(m) of the Code; or

                  (iv)  any revision or amendment requiring shareholder approval
      in order to preserve the qualification of the Plan under Rule 16b-3.

            (b)   Shareholder Approval. If any amendment requiring shareholder
approval under SECTION 13(a) above is made subsequent to the first registration
of any class of equity security by the Company under Section 12 of the Exchange
Act, then such shareholder approval shall be solicited as described in SECTION
20 below.


                                      -12-
<PAGE>   13
            (c)   Effect of Amendment or Termination. Any such amendment or
termination of the Plan shall not affect Options already granted and such
Options shall remain in full force and effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Board, which agreement must be in writing and signed by the Optionee and the
Company.

      18.   Conditions Upon Issuance of Shares.

            (a)   Shares shall not be issued pursuant to the exercise of an
Option or Stock Purchase Right unless the exercise of such Option and the
issuance and delivery of such Shares pursuant thereto shall comply with all
relevant provisions of law, including, without limitation, the Securities Act of
1933, as amended, the Exchange Act, the rules and regulations promulgated
thereunder, and the requirements of any stock exchange upon which the Shares may
then be listed, and shall be further subject to the approval of counsel for the
Company with respect to such compliance.

            (b)   As a condition to the exercise of an Option or Stock Purchase
Right, the Company may require the person exercising such Option or Stock
Purchase Right to represent and warrant at the time of any such exercise that
the Shares are being purchased only for investment and without any present
intention to sell or distribute such Shares if, in the opinion of counsel for
the Company, such a representation is required by any of the aforementioned
relevant provisions of law.

      19.   Reservation of Shares. The Company, during the term of this Plan,
will at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan. The inability of the Company
to obtain authority from any regulatory body having jurisdiction, which
authority is deemed by the Company's counsel to be necessary to the lawful
issuance and sale of any Shares hereunder, shall relieve the Company of any
liability in respect of the failure to issue or sell such Shares as to which
such requisite authority shall not have been obtained.

      20.   Agreements. Options and Stock Purchase Rights shall be evidenced by
written agreements in such form as the Board shall approve from time to time.

      21.   Shareholder Approval.

            (a)   Continuance of the Plan shall be subject to approval by the
shareholders of the Company within twelve (12) months before or after the date
the Plan is adopted. Such shareholder approval shall be obtained in the degree
and manner required under applicable state and federal law and the rules of any
stock exchange upon which the Common Stock is listed.

            (b)   In the event that the Company registers any class of equity
securities pursuant to Section 12 of the Exchange Act, any required approval of
the shareholders of the Company obtained after such registration shall be
solicited substantially in accordance with Section 14(a) of the Exchange Act and
the rules and regulations promulgated thereunder.

            (c)   If any required approval by the shareholders of the Plan
itself or of any amendment thereto is solicited at any time otherwise than in
the manner described in SECTION


                                      -13-
<PAGE>   14
20(b) hereof, then the Company shall, at or prior to the first annual meeting of
shareholders held subsequent to the later of (1) the first registration of any
class of equity securities of the Company under Section 12 of the Exchange Act
or (2) the granting of an Option hereunder to an officer or director after such
registration, do the following:

                  (i)   furnish in writing to the holders entitled to vote for
      the Plan substantially the same information that would be required (if
      proxies to be voted with respect to approval or disapproval of the Plan or
      amendment were then being solicited) by the rules and regulations in
      effect under Section 14(a) of the Exchange Act at the time such
      information is furnished; and

                  (ii)  file with, or mail for filing to, the Securities and
      Exchange Commission four copies of the written information referred to in
      SUBSECTION (i) hereof not later than the date on which such information is
      first sent or given to shareholders.

      22.   Information to Optionees and Purchasers. The Company shall provide
financial statements at least annually to each Optionee and to each individual
who acquired Shares Pursuant to the Plan, during the period such Optionee or
purchaser has one or more Options or Stock Purchase Rights outstanding, and in
the case of an individual who acquired Shares pursuant to the Plan, during the
period such individual owns such Shares. The Company shall not be required to
provide such information if the issuance of Options or Stock Purchase Rights
under the Plan is limited to key employees whose duties in connection with the
Company assure their access to equivalent information.



                                    * * * * *


                                      -14-

<PAGE>   1
                              CONNETICS CORPORATION

                           1995 DIRECTORS' STOCK PLAN

                          (AS AMENDED THROUGH MAY 1999)


      1.    Purposes of the Plan. The purposes of this Directors' Stock Option
Plan are to attract and retain the best available personnel for service as
Directors of the Company, to provide additional incentive to the Outside
Directors of the Company to serve as Directors, and to encourage their continued
service on the Board. All options granted hereunder shall be "nonstatutory stock
options".

      2.    Definitions. As used herein, the following definitions shall apply:

            (a)   "Board" shall mean the Board of Directors of the Company.

            (b)   "Code" shall mean the Internal Revenue Code of 1986, as
amended.

            (c)   "Common Stock" shall mean the Common Stock of the Company.

            (d)   "Company" shall mean Connetics Corporation, a Delaware
corporation.

            (e)   "Continuous Status as a Director" shall mean the absence of
any interruption or termination of service as a Director.

            (f)   "Director" shall mean a member of the Board.

            (g)   "Employee" shall mean any person, including officers and
directors, employed by the Company or any Parent or Subsidiary of the Company.
The payment of a director's fee by the Company shall not be sufficient in and of
itself to constitute "employment" by the Company.

            (h)   "Exchange Act" shall mean the Securities Exchange Act of 1934,
as amended.

            (i)   "Option" shall mean a stock option granted pursuant to the
Plan. All options shall be nonstatutory stock options (i.e., options that are
not intended to qualify as incentive stock options under Section 422 of the
Code).

            (j)   "Optioned Stock" shall mean the Common Stock subject to an
Option.

            (k)   "Optionee" shall mean an Outside Director who receives an
Option.

            (l)   "Outside Director" shall mean a Director who is not an
Employee.

            (m)   "Parent" shall mean a "parent corporation", whether now or
hereafter existing, as defined in Section 424(e) of the Code.

            (n)   "Plan" shall mean this 1995 Directors' Stock Option Plan.


<PAGE>   2
            (o)   "Share" shall mean a share of the Common Stock, as adjusted in
accordance with SECTION 11 of the Plan.

            (p)   "Subsidiary" shall mean a "subsidiary corporation", whether
now or hereafter existing, as defined in Section 424(f) of the Code.

      3.    Stock Subject to the Plan. Subject to the provisions of SECTION 11
of the Plan, the maximum aggregate number of Shares which may be optioned and
sold under the Plan is 400,000 Shares (the "Pool") of Common Stock. The Shares
may be authorized, but unissued, or reacquired Common Stock. If an Option should
expire or become unexercisable for any reason without having been exercised in
full, the unpurchased Shares which were subject thereto shall, unless the Plan
shall have been terminated, become available for future grant under the Plan. If
Shares which were acquired upon exercise of an Option are subsequently
repurchased by the Company, such Shares shall not in any event be returned to
the Plan and shall not become available for future grant under the Plan.

      4.    Administration of and Grants of Options under the Plan.

            (a)   Administrator. Except as otherwise required herein, the Plan
shall be administered by the Board.

            (b)   Procedure for Grants. All grants of Options hereunder shall be
automatic and nondiscretionary and shall be made strictly in accordance with the
following provisions:

                  (i)   No person shall have any discretion to select which
      Outside Directors shall be granted Options or to determine the number of
      Shares to be covered by Options granted to Outside Directors.

                  (ii)  Each Outside Director who first becomes an Outside
      Director after the effective date of this Plan shall be automatically
      granted an Option (the "First Option") to purchase 30,000 Shares on the
      date on which such person first becomes an Outside Director, whether
      through election by the shareholders of the Company or appointment by the
      Board of Directors to fill a vacancy.

                  (iii) Each Outside Director (including Outside Directors who
      were not eligible for a First Option) shall thereafter be automatically
      granted an Option to purchase 7,500 Shares (a "Subsequent Option") on the
      date of each Annual Meeting of the Company's shareholders at which such
      Outside Director is elected, provided that, on such date, he or she shall
      have served on the Board for at least six (6) months prior to the date of
      such Annual Meeting.

                  (iv)  Notwithstanding the provisions of SUBSECTIONS (ii) and
      (iii) hereof, in the event that a grant would cause the number of Shares
      subject to outstanding Options plus the number of Shares previously
      purchased upon exercise of Options to exceed the Pool, then each such
      automatic grant shall be for that number of Shares determined by dividing
      the total number of Shares remaining available for grant by the number of
      Outside Directors receiving an Option on such date on the automatic grant
      date. Any further grants shall then be deferred until such time, if any,
      as additional Shares become available for grant


                                      -2-
<PAGE>   3
      under the Plan through action of the shareholders to increase the number
      of Shares which may be issued under the Plan or through cancellation or
      expiration of Options previously granted hereunder.

                  (v)   Notwithstanding the provisions of SUBSECTIONS (ii) and
      (iii) hereof, any grant of an Option made before the Company has obtained
      shareholder approval of the Plan in accordance with SECTION 17 hereof
      shall be conditioned upon obtaining such shareholder approval of the Plan
      in accordance with SECTION 17 hereof.

                  (vi)  The terms of each First Option granted hereunder shall
      be as follows:

                        (A)   the First Option shall be exercisable only while
            the Outside Director remains a Director of the Company, except as
            set forth in SECTION 9 hereof.

                        (B)   the exercise price per Share shall be 100% of the
            fair market value per Share on the date of grant of the First
            Option, determined in accordance with SECTION 8 hereof.

                        (C)   the First Option shall become exercisable in
            installments cumulatively as to 25% of the Shares subject to the
            First Option on each of the first, second, third and fourth
            anniversaries of the date of grant of the Option.

                  (vii) The terms of each Subsequent Option granted hereunder
      shall be as follows:

                        (A)   the Subsequent Option shall be exercisable only
            while the Outside Director remains a Director of the Company, except
            as set forth in SECTION 9 hereof.

                        (B)   the exercise price per Share shall be 100% of the
            fair market value per Share on the date of grant of the Subsequent
            Option, determined in accordance with SECTION 8 hereof.

                        (C)   the Subsequent Option shall become exercisable as
            to one hundred percent (100%) of the Shares subject to the
            Subsequent Option on the first anniversary of the date of grant of
            the Subsequent Option.

            (c)   Powers of the Board. Subject to the provisions and
restrictions of the Plan, the Board shall have the authority, in its discretion:

                  (i)   to determine, upon review of relevant information and in
      accordance with SECTION 8(b) of the Plan, the fair market value of the
      Common Stock;


                                      -3-
<PAGE>   4
                  (ii)  to determine the exercise price per share of Options to
      be granted, which exercise price shall be determined in accordance with
      SECTION 8(a) of the Plan;

                  (iii) to interpret the Plan;

                  (iv)  to prescribe, amend and rescind rules and regulations
      relating to the Plan;

                  (v)   to authorize any person to execute on behalf of the
      Company any instrument required to effectuate the grant of an Option
      previously granted hereunder; and

                  (vi)  to make all other determinations deemed necessary or
      advisable for the administration of the Plan.

            (d)   Effect of Board's Decision. All decisions, determinations and
interpretations of the Board shall be final and binding on all Optionees and any
other holders of any Options granted under the Plan.

            (e)   Suspension or Termination of Option. If the President or his
or her designee reasonably believes that an Optionee has committed an act of
misconduct, the President may suspend the Optionee's right to exercise any
option pending a determination by the Board of Directors (excluding the Outside
Director accused of such misconduct). If the Board of Directors (excluding the
Outside Director accused of such misconduct) determines an Optionee has
committed an act of embezzlement, fraud, dishonesty, nonpayment of an obligation
owed to the Company, breach of fiduciary duty or deliberate disregard of the
Company rules resulting in loss, damage or injury to the Company, or if an
Optionee makes an unauthorized disclosure of any Company trade secret or
confidential information, engages in any conduct constituting unfair
competition, induces any Company customer to breach a contract with the Company
or induces any principal for whom the Company acts as agent to terminate such
agency relationship, neither the Optionee nor his or her estate shall be
entitled to exercise any option whatsoever. In making such determination, the
Board of Directors (excluding the Outside Director accused of such misconduct)
shall act fairly and shall give the Optionee an opportunity to appear and
present evidence on Optionee's behalf at a hearing before the Board or a
committee of the Board.

      5.    Eligibility. Options may be granted only to Outside Directors. All
Options shall be automatically granted in accordance with the terms set forth in
SECTION 4(b) hereof. An Outside Director who has been granted an Option may, if
he or she is otherwise eligible, be granted an additional Option or Options in
accordance with such provisions. The Plan shall not confer upon any Optionee any
right with respect to continuation of service as a Director or nomination to
serve as a Director, nor shall it interfere in any way with any rights which the
Director or the Company may have to terminate his or her directorship at any
time.

      6.    Term of Plan; Effective Date. The Plan shall become effective on the
earlier to occur of its adoption by the Board of Directors or its approval by
the shareholders of the Company. It shall continue in effect for a term of ten
(10) years unless sooner terminated under SECTION 13 of the Plan.


                                      -4-
<PAGE>   5
      7.    Term of Options. The term of each Option shall be ten (10) years
from the date of grant thereof.

      8.    Exercise Price and Consideration.

            (a)   Exercise Price. The per Share exercise price for the Shares to
be issued pursuant to exercise of an Option shall be 100% of the fair market
value per Share on the date of grant of the Option.

            (b)   Fair Market Value. The fair market value shall be determined
by the Board; provided, however, that where there is a public market for the
Common Stock, the fair market value per Share shall be the mean of the bid and
asked prices of the Common Stock in the over-the-counter market on the date of
grant, as reported in The Wall Street Journal (or, if not so reported, as
otherwise reported by the National Association of Securities Dealers Automated
Quotation ("Nasdaq") System) or, in the event the Common Stock is traded on the
Nasdaq National Market or listed on a stock exchange, the fair market value per
Share shall be the closing price on such system or exchange on the date of grant
of the Option, as reported in The Wall Street Journal. With respect to any
Options granted hereunder concurrently with the initial effectiveness of the
Plan, the fair market value shall be the Price to Public as set forth in the
final prospectus relating to such initial public offering.

            (c)   Form of Consideration. The consideration to be paid for the
Shares to be issued upon exercise of an Option shall consist entirely of cash,
check, other Shares of Common Stock having a fair market value on the date of
surrender equal to the aggregate exercise price of the Shares as to which said
Option shall be exercised (which, if acquired from the Company, shall have been
held for at least six months), or any combination of such methods of payment
and/or any other consideration or method of payment as shall be permitted under
applicable corporate law.

      9.    Exercise of Option.

            (a)   Procedure for Exercise; Rights as a Shareholder.

                  (i)   Any Option granted hereunder shall be exercisable at
      such times as are set forth in SECTION 4(b) hereof; provided, however,
      that no Options shall be exercisable prior to shareholder approval of the
      Plan in accordance with SECTION 17 hereof has been obtained.

                  (ii)  An Option may not be exercised for a fraction of a
      Share.

                  (iii) An Option shall be deemed to be exercised when written
      notice of such exercise has been given to the Company in accordance with
      the terms of the Option by the person entitled to exercise the Option and
      full payment for the Shares with respect to which the Option is exercised
      has been received by the Company. Full payment may consist of any
      consideration and method of payment allowable under SECTION 8(c) of the
      Plan. Until the issuance (as evidenced by the appropriate entry on the
      books of the Company or of a duly authorized transfer agent of the
      Company) of the stock certificate evidencing such Shares, no right to vote
      or receive dividends or any other rights as a shareholder shall exist with


                                      -5-
<PAGE>   6
      respect to the Optioned Stock, notwithstanding the exercise of the Option.
      A share certificate for the number of Shares so acquired shall be issued
      to the Optionee as soon as practicable after exercise of the Option. No
      adjustment will be made for a dividend or other right for which the record
      date is prior to the date the stock certificate is issued, except as
      provided in SECTION 11 of the Plan.

                  (iv)  Exercise of an Option in any manner shall result in a
      decrease in the number of Shares which thereafter may be available, both
      for purposes of the Plan and for sale under the Option, by the number of
      Shares as to which the Option is exercised.

            (b)   Termination of Status as a Director. If an Outside Director
ceases to serve as a Director, he or she may, but only within ninety (90) days
after the date he or she ceases to be a Director of the Company, exercise his or
her Option to the extent that he or she was entitled to exercise it at the date
of such termination. Notwithstanding the foregoing, in no event may the Option
be exercised after its term set forth in SECTION 7 has expired. To the extent
that such Outside Director was not entitled to exercise an Option at the date of
such termination, or does not exercise such Option (which he or she was entitled
to exercise) within the time specified herein, the Option shall terminate.

            (c)   Disability of Optionee. Notwithstanding SECTION 9(b) above, in
the event a Director is unable to continue his or her service as a Director with
the Company as a result of his or her total and permanent disability (as defined
in Section 22(e)(3) of the Internal Revenue Code), he or she may, but only
within six (6) months (or such other period of time not exceeding twelve (12)
months as is determined by the Board) from the date of such termination,
exercise his or her Option to the extent he or she was entitled to exercise it
at the date of such termination. Notwithstanding the foregoing, in no event may
the Option be exercised after its term set forth in SECTION 7 has expired. To
the extent that he or she was not entitled to exercise the Option at the date of
termination, or if he or she does not exercise such Option (which he or she was
entitled to exercise) within the time specified herein, the Option shall
terminate.

            (d)   Death of Optionee. In the event of the death of an Optionee:

                  (i)   During the term of the Option who is, at the time of his
      or her death, a Director of the Company and who shall have been in
      Continuous Status as a Director since the date of grant of the Option, the
      Option may be exercised, at any time within six (6) months following the
      date of death, by the Optionee's estate or by a person who acquired the
      right to exercise the Option by bequest or inheritance, but only to the
      extent of the right to exercise that would have accrued had the Optionee
      continued living and remained in Continuous Status as Director for six (6)
      months (or such lesser period of time as is determined by the Board) after
      the date of death. Notwithstanding the foregoing, in no event may the
      Option be exercised after its term set forth in SECTION 7 has expired.

                  (ii)  Within three (3) months after the termination of
      Continuous Status as a Director, the Option may be exercised, at any time
      within six (6) months following the date of death, by the Optionee's
      estate or by a person who acquired the right to exercise the Option by
      bequest or


                                      -6-
<PAGE>   7
      inheritance, but only to the extent of the right to exercise that had
      accrued at the date of termination. Notwithstanding the foregoing, in no
      event may the option be exercised after its term set forth in SECTION 7
      has expired.

      10.   Nontransferability of Options. The Option may not be sold, pledged,
assigned, hypothecated, transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution or pursuant to a qualified
domestic relations order (as defined by the Code or the rules thereunder). The
designation of a beneficiary by an Optionee does not constitute a transfer. An
Option may be exercised during the lifetime of an Optionee only by the Optionee
or a transferee permitted by this Section.

      11.   Adjustments Upon Changes in Capitalization; Corporate Transactions.

            (a)   Adjustment. Subject to any required action by the shareholders
of the Company, the number of shares of Common Stock covered by each outstanding
Option, and the number of shares of Common Stock which have been authorized for
issuance under the Plan but as to which no Options have yet been granted or
which have been returned to the Plan upon cancellation or expiration of an
Option, as well as the price per share of Common Stock covered by each such
outstanding Option, shall be proportionately adjusted for any increase or
decrease in the number of issued shares of Common Stock resulting from a stock
split, reverse stock split, stock dividend, combination or reclassification of
the Common Stock, or any other increase or decrease in the number of issued
shares of Common Stock effected without receipt of consideration by the Company;
provided, however, that conversion of any convertible securities of the Company
shall not be deemed to have been "effected without receipt of consideration."
Such adjustment shall be made by the Board, whose determination in that respect
shall be final, binding and conclusive. Except as expressly provided herein, no
issuance by the Company of shares of stock of any class, or securities
convertible into shares of stock of any class, shall affect, and no adjustment
by reason thereof shall be made with respect to, the number or price of shares
of Common Stock subject to an Option.

            (b)   Corporate Transactions. In the event of (i) a dissolution or
liquidation of the Company, (ii) a sale of all or substantially all of the
Company's assets, (iii) a merger or consolidation in which the Company is not
the surviving corporation, or (iv) any other capital reorganization in which
more than fifty percent (50%) of the shares of the Company entitled to vote are
exchanged, the Company shall give to the Eligible Director, at the time of
adoption of the plan for liquidation, dissolution, sale, merger, consolidation
or reorganization, either a reasonable time thereafter within which to exercise
the Option, including Shares as to which the Option would not be otherwise
exercisable, prior to the effectiveness of such liquidation, dissolution, sale,
merger, consolidation or reorganization, at the end of which time the Option
shall terminate, or the right to exercise the Option, including Shares as to
which the Option would not be otherwise exercisable (or receive a substitute
option with comparable terms), as to an equivalent number of shares of stock of
the corporation succeeding the Company or acquiring its business by reason of
such liquidation, dissolution, sale, merger, consolidation or reorganization.


                                      -7-
<PAGE>   8
      12.   Time of Granting Options. The date of grant of an Option shall, for
all purposes, be the date determined in accordance with SECTION 4(B) hereof.
Notice of the determination shall be given to each Outside Director to whom an
Option is so granted within a reasonable time after the date of such grant.

      13.   Amendment and Termination of the Plan.

            (a)   Amendment and Termination. The Board may amend or terminate
the Plan from time to time in such respects as the Board may deem advisable;
provided that, to the extent necessary and desirable to comply with Rule 16b-3
under the Exchange Act (or any other applicable law or regulation), the Company
shall obtain approval of the shareholders of the Company to Plan amendments to
the extent and in the manner required by such law or regulation. Notwithstanding
the foregoing, the provisions set forth in SECTION 4 of this Plan (and any other
Sections of this Plan that affect the formula award terms required to be
specified in this Plan by Rule 16b-3) shall not be amended more than once every
six months, other than to comport with changes in the Code, the Employee
Retirement Income Security Act of 1974, as amended, or the rules thereunder.

            (b)   Effect of Amendment or Termination. Any such amendment or
termination of the Plan that would impair the rights of any Optionee shall not
affect Options already granted to such Optionee and such Options shall remain in
full force and effect as if this Plan had not been amended or terminated, unless
mutually agreed otherwise between the Optionee and the Board, which agreement
must be in writing and signed by the Optionee and the Company.

      14.   Conditions Upon Issuance of Shares. Shares shall not be issued
pursuant to the exercise of an Option unless the exercise of such Option and the
issuance and delivery of such Shares pursuant thereto shall comply with all
relevant provisions of law, including, without limitation, the Securities Act of
1933, as amended, the Exchange Act, the rules and regulations promulgated
thereunder, state securities laws, and the requirements of any stock exchange
upon which the Shares may then be listed, and shall be further subject to the
approval of counsel for the Company with respect to such compliance. As a
condition to the exercise of an Option, the Company may require the person
exercising such Option to represent and warrant at the time of any such exercise
that the Shares are being purchased only for investment and without any present
intention to sell or distribute such Shares, if, in the opinion of counsel for
the Company, such a representation is required by any of the aforementioned
relevant provisions of law.

      15.   Reservation of Shares. The Company, during the term of this Plan,
will at all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan. Inability of the Company to
obtain authority from any regulatory body having jurisdiction, which authority
is deemed by the Company's counsel to be necessary to the lawful issuance and
sale of any Shares hereunder, shall relieve the Company of any liability in
respect of the failure to issue or sell such Shares as to which such requisite
authority shall not have been obtained.

      16.   Option Agreement. Options shall be evidenced by written option
agreements in such form as the Board shall approve.

      17.   Shareholder Approval. Continuance of the Plan shall be subject to
approval by the shareholders of the Company at or prior to the first annual
meeting of shareholders held


                                      -8-
<PAGE>   9
subsequent to the granting of an Option hereunder. If such shareholder approval
is obtained at a duly held shareholders' meeting, it may be obtained by the
affirmative vote of the holders of a majority of the outstanding shares of the
Company present or represented and entitled to vote thereon. If such shareholder
approval is obtained by written consent, it may be obtained by the written
consent of the holders of a majority of the outstanding shares of the Company.
Options may be granted, but not exercised, before such shareholder approval.


                                    * * * * *


                                      -9-

<PAGE>   1
                                                                Exhibit 4.4


                             CONNETICS CORPORATION

                               STOCK PLAN (2000)

     1. Purposes of the Plan. The purposes of this Stock Plan (2000) are:

     - to attract and retain the best available personnel for positions of
       substantial responsibility,

     - to provide additional incentive to Employees, Directors and Consultants,
       and

     - to promote the success of Connetics' business.

     Options granted under the Plan may be Incentive Stock Options or
Nonstatutory Stock Options, as determined by the Administrator at the time of
grant. Stock Purchase Rights may also be granted under the Plan.

     2. Definitions. As used in this Plan, the following definitions shall
apply:

          (a) "Administrator" means the Board or any of its Committees as shall
     be administering the Plan, in accordance with SECTION 4 of the Plan.

          (b) "Applicable Laws" means the requirements relating to the
     administration of stock option plans under U. S. state corporate laws, U.S.
     federal and state securities laws, the Code, any stock exchange or
     quotation system on which the Common Stock is listed or quoted and the
     applicable laws of any foreign country or jurisdiction where Options or
     Stock Purchase Rights are, or will be, granted under the Plan.

          (c) "Board" means the Board of Directors of Connetics.

          (d) "Code" means the Internal Revenue Code of 1986, as amended.

          (e) "Committee" means a committee of Directors appointed by the Board
     in accordance with SECTION 4 of the Plan.

          (f) "Common Stock" means the common stock of Connetics.

          (g) "Company" means Connetics Corporation, a Delaware corporation.

          (h) "Consultant" means any person, including an advisor, engaged by
     Connetics or a Parent or Subsidiary to render services to such entity.

          (i) "Director" means a member of the Board.

          (j) "Disability" means total and permanent disability as defined in
     Section 22(e)(3) of the Code.

          (k) "Employee" means any person, including Officers and Directors,
     employed by Connetics or any Parent or Subsidiary of Connetics. A Service
     Provider shall not cease to be an Employee in the case of (i) any leave of
     absence approved by Connetics or (ii) transfers between locations of
     Connetics or between Connetics, its Parent, any Subsidiary, or any
     successor. For purposes of Incentive Stock Options, no such leave may
     exceed ninety days, unless reemployment upon expiration of such leave is
     guaranteed by statute or contract. If reemployment upon expiration of a
     leave of absence approved by Connetics is not so guaranteed, on the 181st
     day of such leave any Incentive Stock Option held by the Optionee shall
     cease to be treated as an Incentive Stock Option and shall be treated for
     tax purposes as a Nonstatutory Stock Option. Neither service as a Director
     nor payment of a director's fee by Connetics shall be sufficient to
     constitute "employment" by Connetics.

          (l) "Exchange Act" means the Securities Exchange Act of 1934, as
     amended.

          (m) "Fair Market Value" means, as of any date, the value of Common
     Stock determined as follows:

             (i) If the Common Stock is listed on any established stock exchange
        or a national market system, including without limitation the Nasdaq
        National Market or The Nasdaq SmallCap Market of The Nasdaq Stock
        Market, its Fair Market Value shall be the closing sales price for such
        stock

                                       E-1
<PAGE>   2

        (or the closing bid, if no sales were reported) as quoted on such
        exchange or system for the last market trading day prior to the time of
        determination, as reported in The Wall Street Journal or such other
        source as the Administrator deems reliable;

             (ii) If the Common Stock is regularly quoted by a recognized
        securities dealer but selling prices are not reported, the Fair Market
        Value of a Share of Common Stock shall be the mean between the high bid
        and low asked prices for the Common Stock on the last market trading day
        prior to the day of determination, as reported in The Wall Street
        Journal or such other source as the Administrator deems reliable; or

             (iii) In the absence of an established market for the Common Stock,
        the Fair Market Value shall be determined in good faith by the
        Administrator.

          (n) "Incentive Stock Option" means an Option intended to qualify as an
     incentive stock option within the meaning of Section 422 of the Code and
     the regulations promulgated thereunder.

          (o) "Nonstatutory Stock Option" means an Option not intended to
     qualify as an Incentive Stock Option.

          (p) "Notice of Grant" means a written or electronic notice evidencing
     certain terms and conditions of an individual Option or Stock Purchase
     Right grant. The Notice of Grant is part of the Option Agreement.

          (q) "Officer" means a person who is an officer of Connetics within the
     meaning of Section 16 of the Exchange Act and the rules and regulations
     promulgated under the Exchange Act.

          (r) "Option" means a stock option granted pursuant to the Plan.

          (s) "Option Agreement" means an agreement between Connetics and an
     Optionee evidencing the terms and conditions of an individual Option grant.
     The Option Agreement is subject to the terms and conditions of the Plan.

          (t) "Option Exchange Program" means a program whereby outstanding
     Options are surrendered in exchange for Options with a lower exercise
     price.

          (u) "Optioned Stock" means the Common Stock subject to an Option or
     Stock Purchase Right.

          (v) "Optionee" means the holder of an outstanding Option or Stock
     Purchase Right granted under the Plan.

          (w) "Parent" means a "parent corporation," whether now or hereafter
     existing, as defined in Section 424(e) of the Code.

          (x) "Plan" means this Stock Plan (2000).

          (y) "Restricted Stock" means shares of Common Stock acquired pursuant
     to a grant of Stock Purchase Rights under SECTION 11 of the Plan.

          (z) "Restricted Stock Purchase Agreement" means a written agreement
     between Connetics and the Optionee evidencing the terms and restrictions
     applying to stock purchased under a Stock Purchase Right. The Restricted
     Stock Purchase Agreement is subject to the terms and conditions of the Plan
     and the Notice of Grant.

          (aa) "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any
     successor to Rule 16b-3, as in effect when discretion is being exercised
     with respect to the Plan.

          (bb) "Section 16(b)" means Section 16(b) of the Exchange Act.

          (cc) "Service Provider" means an Employee, Director or Consultant.

          (dd) "Share" means a share of the Common Stock, as adjusted in
     accordance with SECTION 13 of the Plan.

                                       E-2
<PAGE>   3

          (ee) "Stock Purchase Right" means the right to purchase Common Stock
     pursuant to SECTION 11 of the Plan, as evidenced by a Notice of Grant.

          (ff) "Subsidiary" means a "subsidiary corporation", whether now or
     hereafter existing, as defined in Section 424(f) of the Code.

     3. Stock Subject to the Plan. Subject to the provisions of SECTION 13 of
the Plan, the maximum aggregate number of Shares which may be optioned and sold
under the Plan shall be three percent (3%) of all common stock of the Company
outstanding as of December 31, 1999 plus an annual increase to be added on each
January 1 equal to the lesser of (a) three percent (3%) of the outstanding
Shares on such date, or (b) a lesser amount determined by the Board; provided,
however, that the maximum number of Shares that may be issued under this Plan
pursuant to Incentive Stock Options is 8,000,000 during the term of the Plan.
The Shares may be authorized, but unissued, or reacquired Common Stock.

     If an Option or Stock Purchase Right expires or becomes unexercisable
without having been exercised in full, or is surrendered pursuant to an Option
Exchange Program, the unpurchased Shares which were subject to that Option or
Stock Purchase Right shall become available for future grant or sale under the
Plan (unless the Plan has terminated); provided, however, that Shares that have
actually been issued under the Plan, whether upon exercise of an Option or
Right, shall not be returned to the Plan and shall not become available for
future distribution under the Plan, except that if Shares of Restricted Stock
are repurchased by Connetics at their original purchase price, such Shares shall
become available for future grant under the Plan.

     4. Administration of the Plan.

          (a) Procedure.

          (i) Multiple Administrative Bodies. The Plan may be administered by
     different Committees with respect to different groups of Service Providers.

          (ii) Section 162(m). To the extent that the Administrator determines
     it to be desirable to qualify Options granted under this Plan as
     "performance-based compensation" within the meaning of Section 162(m) of
     the Code, the Plan shall be administered by a Committee of two or more
     "outside directors" within the meaning of Section 162(m) of the Code.

          (iii) Rule 16b-3. To the extent desirable to qualify transactions
     under this Plan as exempt under Rule 16b-3, the transactions contemplated
     under this Plan shall be structured to satisfy the requirements for
     exemption under Rule 16b-3.

          (iv) Other Administration. Other than as provided above, the Plan
     shall be administered by (A) the Board or (B) a Committee, which committee
     shall be constituted to satisfy Applicable Laws.

     (b) Powers of the Administrator. Subject to the provisions of the Plan, and
in the case of a Committee, subject to the specific duties delegated by the
Board to such Committee, the Administrator shall have the authority, in its
discretion:

             (i) to determine the Fair Market Value;

             (ii) to select the Service Providers to whom Options and Stock
        Purchase Rights may be granted under this Plan;

             (iii) to determine the number of shares of Common Stock to be
        covered by each Option and Stock Purchase Right granted under this Plan;

             (iv) to approve forms of agreement for use under the Plan;

             (v) to determine the terms and conditions, not inconsistent with
        the terms of the Plan, of any Option or Stock Purchase Right granted
        under this Plan. Such terms and conditions include, but are not limited
        to, the exercise price, the time or times when Options or Stock Purchase
        Rights may be exercised (which may be based on performance criteria),
        any vesting acceleration or waiver of forfeiture restrictions, and any
        restriction or limitation regarding any Option or Stock Purchase Right

                                       E-3
<PAGE>   4

        or the shares of Common Stock relating thereto, based in each case on
        such factors as the Administrator, in its sole discretion, shall
        determine;

             (vi) to reduce the exercise price of any Option or Stock Purchase
        Right to the then current Fair Market Value if the Fair Market Value of
        the Common Stock covered by such Option or Stock Purchase Right shall
        have declined since the date the Option or Stock Purchase Right was
        granted;

             (vii) to institute an Option Exchange Program;

             (viii) to construe and interpret the terms of the Plan and awards
        granted pursuant to the Plan;

             (ix) to prescribe, amend and rescind rules and regulations relating
        to the Plan, including rules and regulations relating to sub-plans
        established for the purpose of qualifying for preferred tax treatment
        under foreign tax laws;

             (x) to modify or amend each Option or Stock Purchase Right (subject
        to Section 15(c) of the Plan), including the discretionary authority to
        extend the post-termination exercisability period of Options longer than
        is otherwise provided for in the Plan;

             (xi) to allow Optionees to satisfy withholding tax obligations by
        electing to have Connetics withhold from the Shares to be issued upon
        exercise of an Option or Stock Purchase Right that number of Shares
        having a Fair Market Value equal to the amount required to be withheld.
        The Fair Market Value of the Shares to be withheld shall be determined
        on the date that the amount of tax to be withheld is to be determined.
        All elections by an Optionee to have Shares withheld for this purpose
        shall be made in such form and under such conditions as the
        Administrator may deem necessary or advisable;

             (xii) to authorize any person to execute on behalf of Connetics any
        instrument required to effect the grant of an Option or Stock Purchase
        Right previously granted by the Administrator;

             (xiii) to make all other determinations deemed necessary or
        advisable for administering the Plan.

          (c) Effect of Administrator's Decision. The Administrator's decisions,
     determinations and interpretations shall be final and binding on all
     Optionees and any other holders of Options or Stock Purchase Rights.

     5. Eligibility. Nonstatutory Stock Options and Stock Purchase Rights may be
granted to Service Providers. Incentive Stock Options may be granted only to
Employees.

     6. Limitations.

     (a) Each Option shall be designated in the Option Agreement as either an
Incentive Stock Option or a Nonstatutory Stock Option. However, notwithstanding
such designation, to the extent that the aggregate Fair Market Value of the
Shares with respect to which Incentive Stock Options are exercisable for the
first time by the Optionee during any calendar year (under all plans of
Connetics and any Parent or Subsidiary) exceeds $100,000, such Options shall be
treated as Nonstatutory Stock Options. For purposes of this SECTION 6(A),
Incentive Stock Options shall be taken into account in the order in which they
were granted. The Fair Market Value of the Shares shall be determined as of the
time the Option with respect to such Shares is granted.

     (b) Neither the Plan nor any Option or Stock Purchase Right shall confer
upon an Optionee any right with respect to continuing the Optionee's
relationship as a Service Provider with Connetics, nor shall they interfere in
any way with the Optionee's right or Connetics' right to terminate such
relationship at any time, with or without cause.

     (c) The following limitations shall apply to grants of Options:

          (i) No Service Provider shall be granted, in any fiscal year of
     Connetics, Options to purchase more than 300,000 Shares.

                                       E-4
<PAGE>   5

          (ii) In connection with his or her initial service, a Service Provider
     may be granted Options to purchase up to an additional 300,000 Shares,
     which shall not count against the limit, set forth in subsection (i) above.

          (iii) The foregoing limitations shall be adjusted proportionately in
     connection with any change in Connetics' capitalization as described in
     SECTION 13.

          (iv) If an Option is cancelled in the same fiscal year of Connetics in
     which it was granted (other than in connection with a transaction described
     in SECTION 13), the cancelled Option will be counted against the limits set
     forth in subsections (i) and (ii) above. For this purpose, if the exercise
     price of an Option is reduced, the transaction will be treated as a
     cancellation of the Option and the grant of a new Option.

     7. Term of Plan. Subject to SECTION 19 of the Plan, the Plan shall become
effective January 1, 2000 after its adoption by the Board. It shall continue in
effect for a term of ten (10) years unless terminated earlier under SECTION 15
of the Plan.

     8. Term of Option. The term of each Option shall be stated in the Option
Agreement. In the case of an Incentive Stock Option, the term shall be ten (10)
years from the date of grant or such shorter term as may be provided in the
Option Agreement. Moreover, in the case of an Incentive Stock Option granted to
an Optionee who, at the time the Incentive Stock Option is granted, owns stock
representing more than ten percent (10%) of the total combined voting power of
all classes of stock of Connetics or any Parent or Subsidiary, the term of the
Incentive Stock Option shall be five (5) years from the date of grant or such
shorter term as may be provided in the Option Agreement.

     9. Option Exercise Price and Consideration.

          (a) Exercise Price. The per share exercise price for the Shares to be
     issued pursuant to exercise of an Option shall be determined by the
     Administrator, subject to the following:

           (i) In the case of an Incentive Stock Option

                (A) granted to an Employee who, at the time the Incentive Stock
           Option is granted, owns stock representing more than ten percent
           (10%) of the voting power of all classes of stock of Connetics or any
           Parent or Subsidiary, the per Share exercise price shall be no less
           than 110% of the Fair Market Value per Share on the date of grant.

               (B) granted to any Employee other than an Employee described in
           paragraph (A) immediately above, the per Share exercise price shall
           be no less than 100% of the Fair Market Value per Share on the date
           of grant.

             (ii) In the case of a Nonstatutory Stock Option, the per Share
        exercise price shall be determined by the Administrator. In the case of
        a Nonstatutory Stock Option intended to qualify as "performance-based
        compensation" within the meaning of Section 162(m) of the Code, the per
        Share exercise price shall be no less than 100% of the Fair Market Value
        per Share on the date of grant.

             (iii) Notwithstanding the foregoing, Options may be granted with a
        per Share exercise price of less than 100% of the Fair Market Value per
        Share on the date of grant pursuant to a merger or other corporate
        transaction.

          (b) Waiting Period and Exercise Dates. At the time an Option is
     granted, the Administrator shall fix the period within which the Option may
     be exercised and shall determine any conditions, which must be satisfied
     before the Option may be exercised.

                                       E-5
<PAGE>   6

          (c) Form of Consideration. The Administrator shall determine the
     acceptable form of consideration for exercising an Option, including the
     method of payment. In the case of an Incentive Stock Option, the
     Administrator shall determine the acceptable form of consideration at the
     time of grant. Such consideration may consist entirely of:

           (i) cash;

             (ii) check;

             (iii) promissory note;

             (iv) other Shares which (A) in the case of Shares acquired upon
        exercise of an option, have been owned by the Optionee for more than six
        months on the date of surrender, and (B) have a Fair Market Value on the
        date of surrender equal to the aggregate exercise price of the Shares as
        to which said Option shall be exercised;

             (v) consideration received by Connetics under a cashless exercise
        program implemented by Connetics in connection with the Plan;

             (vi) a reduction in the amount of any Company liability to the
        Optionee, including any liability attributable to the Optionee's
        participation in any Company-sponsored deferred compensation program or
        arrangement;

             (vii) any combination of the foregoing methods of payment; or

             (viii) such other consideration and method of payment for the
        issuance of Shares to the extent permitted by Applicable Laws.

     10. Exercise of Option.

     (a) Procedure for Exercise; Rights as a Stockholder. Any Option granted
under this Plan shall be exercisable according to the terms of the Plan and at
such times and under such conditions as determined by the Administrator and set
forth in the Option Agreement. Unless the Administrator provides otherwise,
vesting of Options granted under this Plan shall be tolled during any unpaid
leave of absence. An Option may not be exercised for a fraction of a Share.

     An Option shall be deemed exercised when Connetics receives: (i) written or
electronic notice of exercise (in accordance with the Option Agreement) from the
person entitled to exercise the Option, and (ii) full payment for the Shares
with respect to which the Option is exercised. Full payment may consist of any
consideration and method of payment authorized by the Administrator and
permitted by the Option Agreement and the Plan. Shares issued upon exercise of
an Option shall be issued in the name of the Optionee or, if requested by the
Optionee, in the name of the Optionee and his or her spouse. Until the Shares
are issued (as evidenced by the appropriate entry on the books of Connetics or
of a duly authorized transfer agent of Connetics), no right to vote or receive
dividends or any other rights as a stockholder shall exist with respect to the
Optioned Stock, notwithstanding the exercise of the Option. Connetics shall
issue (or cause to be issued) such Shares promptly after the Option is
exercised. No adjustment will be made for a dividend or other right for which
the record date is prior to the date the Shares are issued, except as provided
in SECTION 13 of the Plan.

     Exercising an Option in any manner shall decrease the number of Shares
thereafter available, both for purposes of the Plan and for sale under the
Option, by the number of Shares as to which the Option is exercised.

     (b) Termination of Relationship as a Service Provider. If an Optionee
ceases to be a Service Provider, other than upon the Optionee's death or
Disability, the Optionee may exercise his or her Option within such period of
time as is specified in the Option Agreement to the extent that the Option is
vested on the date of termination (but in no event later than the expiration of
the term of such Option as set forth in the Option Agreement). In the absence of
a specified time in the Option Agreement, the Option shall remain exercisable
for three (3) months following the Optionee's termination. If, on the date of
termination, the Optionee is not

                                       E-6
<PAGE>   7

vested as to his or her entire Option, the Shares covered by the unvested
portion of the Option shall revert to the Plan. If, after termination, the
Optionee does not exercise his or her Option within the time specified by the
Administrator, the Option shall terminate, and the Shares covered by such Option
shall revert to the Plan.

     (c) Disability of Optionee. If an Optionee ceases to be a Service Provider
as a result of the Optionee's Disability, the Optionee may exercise his or her
Option within such period of time as is specified in the Option Agreement to the
extent the Option is vested on the date of termination (but in no event later
than the expiration of the term of such Option as set forth in the Option
Agreement). In the absence of a specified time in the Option Agreement, the
Option shall remain exercisable for twelve (12) months following the Optionee's
termination. If, on the date of termination, the Optionee is not vested as to
his or her entire Option, the Shares covered by the unvested portion of the
Option shall revert to the Plan. If, after termination, the Optionee does not
exercise his or her Option within the time specified in this Plan, the Option
shall terminate, and the Shares covered by such Option shall revert to the Plan.

     (d) Death of Optionee. If an Optionee dies while a Service Provider, the
Option may be exercised within such period of time as is specified in the Option
Agreement (but in no event later than the expiration of the term of such Option
as set forth in the Notice of Grant), by the Optionee's estate or by a person
who acquires the right to exercise the Option by bequest or inheritance, but
only to the extent that the Option is vested on the date of death. In the
absence of a specified time in the Option Agreement, the Option shall remain
exercisable for twelve (12) months following the Optionee's termination. If, at
the time of death, the Optionee is not vested as to his or her entire Option,
the Shares covered by the unvested portion of the Option shall immediately
revert to the Plan. The Option may be exercised by the executor or administrator
of the Optionee's estate or, if none, by the person(s) entitled to exercise the
Option under the Optionee's will or the laws of descent or distribution. If the
Option is not so exercised within the time specified in this Plan, the Option
shall terminate, and the Shares covered by such Option shall revert to the Plan.

     (e) Buyout Provisions. The Administrator may at any time offer to buy out
for a payment in cash or Shares an Option previously granted based on such terms
and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     11. Stock Purchase Rights.

     (a) Rights to Purchase. Stock Purchase Rights may be issued either alone,
in addition to, or in tandem with other awards granted under the Plan and/or
cash awards made outside of the Plan. After the Administrator determines that it
will offer Stock Purchase Rights under the Plan, it shall advise the offeree in
writing or electronically, by means of a Notice of Grant, of the terms,
conditions and restrictions related to the offer, including the number of Shares
that the offeree shall be entitled to purchase, the price to be paid, and the
time within which the offeree must accept such offer. The offer shall be
accepted by execution of a Restricted Stock Purchase Agreement in the form
determined by the Administrator.

     (b) Repurchase Option. Unless the Administrator determines otherwise, the
Restricted Stock Purchase Agreement shall grant Connetics a repurchase option
exercisable upon the voluntary or involuntary termination of the purchaser's
service with Connetics for any reason (including death or Disability). The
purchase price for Shares repurchased pursuant to the Restricted Stock Purchase
Agreement shall be the original price paid by the purchaser and may be paid by
cancellation of any indebtedness of the purchaser to Connetics. The repurchase
option shall lapse at a rate determined by the Administrator.

     (c) Other Provisions. The Restricted Stock Purchase Agreement shall contain
such other terms, provisions and conditions not inconsistent with the Plan as
may be determined by the Administrator in its sole discretion.

     (d) Rights as a Stockholder. Once the Stock Purchase Right is exercised,
the purchaser shall have the rights equivalent to those of a stockholder, and
shall be a stockholder when his or her purchase is entered upon the records of
the duly authorized transfer agent of Connetics. No adjustment will be made for
a dividend or other right for which the record date is prior to the date the
Stock Purchase Right is exercised, except as provided in SECTION 13 of the Plan.

                                       E-7
<PAGE>   8

     12. Non-Transferability of Options and Stock Purchase Rights. Unless
determined otherwise by the Administrator, an Option or Stock Purchase Right may
not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any
manner other than by will or by the laws of descent or distribution and may be
exercised, during the lifetime of the Optionee, only by the Optionee. If the
Administrator makes an Option or Stock Purchase Right transferable, such Option
or Stock Purchase Right shall contain such additional terms and conditions as
the Administrator deems appropriate.

     13. Adjustments Upon Changes in Capitalization, Dissolution, Merger or
Asset Sale.

     (a) Changes in Capitalization. Subject to any required action by the
stockholders of Connetics, the number of shares of Common Stock covered by each
outstanding Option and Stock Purchase Right, and the number of shares of Common
Stock which have been authorized for issuance under the Plan but as to which no
Options or Stock Purchase Rights have yet been granted or which have been
returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, as well as the price per share of Common Stock covered by each
such outstanding Option or Stock Purchase Right, shall be proportionately
adjusted for any increase or decrease in the number of issued shares of Common
Stock resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Common Stock, or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of consideration by Connetics; provided, however, that conversion of any
convertible securities of Connetics shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided in this Plan, no issuance by Connetics of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall affect, and no adjustment by reason thereof shall be made with respect to,
the number or price of shares of Common Stock subject to an Option or Stock
Purchase Right.

     (b) Dissolution or Liquidation. In the event of the proposed dissolution or
liquidation of Connetics, the Administrator shall notify each Optionee as soon
as practicable prior to the effective date of such proposed transaction. The
Administrator in its discretion may provide for an Optionee to have the right to
exercise his or her Option until ten (10) days prior to such transaction as to
all of the Optioned Stock covered thereby, including Shares as to which the
Option would not otherwise be exercisable. In addition, the Administrator may
provide that any Company repurchase option applicable to any Shares purchased
upon exercise of an Option or Stock Purchase Right shall lapse as to all such
Shares, provided the proposed dissolution or liquidation takes place at the time
and in the manner contemplated. To the extent it has not been previously
exercised, an Option or Stock Purchase Right will terminate immediately prior to
the consummation of such proposed action.

     (c) Merger or Asset Sale. In the event of a merger of Connetics with or
into another corporation, or the sale of substantially all of the assets of
Connetics, each outstanding Option and Stock Purchase Right shall be assumed or
an equivalent option or right substituted by the successor corporation or a
Parent or Subsidiary of the successor corporation. In the event that the
successor corporation refuses to assume or substitute for the Option or Stock
Purchase Right, the Optionee shall fully vest in and have the right to exercise
the Option or Stock Purchase Right as to all of the Optioned Stock, including
Shares as to which it would not otherwise be vested or exercisable. If an Option
or Stock Purchase Right becomes fully vested and exercisable in lieu of
assumption or substitution in the event of a merger or sale of assets, the
Administrator shall notify the Optionee in writing or electronically that the
Option or Stock Purchase Right shall be fully vested and exercisable for a
period of fifteen (15) days from the date of such notice, and the Option or
Stock Purchase Right shall terminate upon the expiration of such period. For the
purposes of this paragraph, the Option or Stock Purchase Right shall be
considered assumed if, following the merger or sale of assets, the option or
right confers the right to purchase or receive, for each Share of Optioned Stock
subject to the Option or Stock Purchase Right immediately prior to the merger or
sale of assets, the consideration (whether stock, cash, or other securities or
property) received in the merger or sale of assets by holders of Common Stock
for each Share held on the effective date of the transaction (and if holders
were offered a choice of consideration, the type of consideration chosen by the
holders of a majority of the outstanding Shares); provided, however, that if
such consideration received in the merger or sale of assets is not solely common
stock of the successor corporation or its Parent, the Administrator may, with
the consent of the successor corporation, provide for the
                                       E-8
<PAGE>   9

consideration to be received upon the exercise of the Option or Stock Purchase
Right, for each Share of Optioned Stock subject to the Option or Stock Purchase
Right, to be solely common stock of the successor corporation or its Parent
equal in fair market value to the per share consideration received by holders of
Common Stock in the merger or sale of assets.

     14. Date of Grant. The date of grant of an Option or Stock Purchase Right
shall be, for all purposes, the date on which the Administrator makes the
determination granting such Option or Stock Purchase Right, or such other later
date as is determined by the Administrator. Notice of the determination shall be
provided to each Optionee within a reasonable time after the date of such grant.

     15. Amendment and Termination of the Plan.

     (a) Amendment and Termination. The Board may at any time amend, alter,
suspend or terminate the Plan.

     (b) Stockholder Approval. Connetics shall obtain stockholder approval of
any Plan amendment to the extent necessary and desirable to comply with
Applicable Laws.

     (c) Effect of Amendment or Termination. No amendment, alteration,
suspension or termination of the Plan shall impair the rights of any Optionee,
unless mutually agreed otherwise between the Optionee and the Administrator,
which agreement must be in writing and signed by the Optionee and Connetics.
Termination of the Plan shall not affect the Administrator's ability to exercise
the powers granted to it under this Plan with respect to Options granted under
the Plan prior to the date of such termination.

     16. Conditions Upon Issuance of Shares.

     (a) Legal Compliance. Shares shall not be issued pursuant to the exercise
of an Option or Stock Purchase Right unless the exercise of such Option or Stock
Purchase Right and the issuance and delivery of such Shares shall comply with
Applicable Laws and shall be further subject to the approval of counsel for
Connetics with respect to such compliance.

     (b) Investment Representations. As a condition to the exercise of an Option
or Stock Purchase Right, Connetics may require the person exercising such Option
or Stock Purchase Right to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for Connetics, such a representation is required.

     17. Inability to Obtain Authority. The inability of Connetics to obtain
authority from any regulatory body having jurisdiction, which authority is
deemed by Connetics' counsel to be necessary to the lawful issuance and sale of
any Shares under this Plan, shall relieve Connetics of any liability in respect
of the failure to issue or sell such Shares as to which such requisite authority
shall not have been obtained.

     18. Reservation of Shares. Connetics, during the term of this Plan, will at
all times reserve and keep available such number of Shares as shall be
sufficient to satisfy the requirements of the Plan.

     19. Stockholder Approval. The Plan shall be subject to approval by the
stockholder of Connetics within twelve (12) months after the date the Plan is
adopted. Such stockholder approval shall be obtained in the manner and to the
degree required under Applicable Laws.

                                       E-9
<PAGE>   10

                             CONNETICS CORPORATION

                               STOCK PLAN (2000)

                             STOCK OPTION AGREEMENT

     Unless otherwise defined in this Plan, the terms defined in the Plan shall
have the same defined meanings in this Option Agreement.

I.  NOTICE OF STOCK OPTION GRANT

     [OPTIONEE'S NAME AND ADDRESS]

     You have been granted an option to purchase Common Stock of Connetics,
subject to the terms and conditions of the Plan and this Option Agreement, as
follows:

<TABLE>
<S>                                     <C>
Grant Number..........................
Date of Grant.........................
Vesting Commencement Date.............
Exercise Price per Share..............  $
Total Number of Shares Granted........
Total Exercise Price..................  $
Type of Option:.......................  Incentive Stock Option
                                        Nonstatutory Stock Option
Term/Expiration Date:.................
</TABLE>

  Vesting Schedule:

     This Option may be exercised, in whole or in part, in accordance with the
following schedule:

     [25% OF THE SHARES SUBJECT TO THE OPTION SHALL VEST TWELVE MONTHS AFTER THE
VESTING COMMENCEMENT DATE, AND 1/48 OF THE SHARES SUBJECT TO THE OPTION SHALL
VEST EACH MONTH THEREAFTER, SUBJECT TO THE OPTIONEE CONTINUING TO BE A SERVICE
PROVIDER ON SUCH DATES].

  Termination Period:

     This Option may be exercised for           [DAYS/MONTHS] after Optionee
ceases to be a Service Provider. Upon the death or Disability of the Optionee,
this Option may be exercised for [ONE YEAR] after Optionee ceases to be a
Service Provider. In no event shall this Option be exercised later than the
Term/ Expiration Date as provided above.

II.  AGREEMENT

     1. Grant of Option. The Plan Administrator of Connetics hereby grants to
the Optionee named in the Notice of Grant attached as Part I of this Agreement
(the "Optionee") an option (the "Option") to purchase the number of Shares, as
set forth in the Notice of Grant, at the exercise price per share set forth in
the Notice of Grant (the "Exercise Price"), subject to the terms and conditions
of the Plan, which is incorporated in this Agreement by reference. Subject to
Section 15(c) of the Plan, in the event of a conflict between the terms and
conditions of the Plan and the terms and conditions of this Option Agreement,
the terms and conditions of the Plan shall prevail.

     If designated in the Notice of Grant as an Incentive Stock Option ("ISO"),
this Option is intended to qualify as an Incentive Stock Option under Section
422 of the Code. However, if this Option is intended to be an Incentive Stock
Option, to the extent that it exceeds the $100,000 rule of Code Section 422(d)
it shall be treated as a Nonstatutory Stock Option ("NSO").

                                      E-10
<PAGE>   11

     2. Exercise of Option.

     (a) Right to Exercise. This Option is exercisable during its term in
accordance with the Vesting Schedule set out in the Notice of Grant and the
applicable provisions of the Plan and this Option Agreement.

     (b) Method of Exercise. This Option is exercisable by delivery of an
exercise notice, in the form attached as Exhibit A (the "Exercise Notice"),
which shall state the election to exercise the Option, the number of Shares in
respect of which the Option is being exercised (the "Exercised Shares"), and
such other representations and agreements as may be required by Connetics
pursuant to the provisions of the Plan. The Exercise Notice shall be completed
by the Optionee and delivered to the Secretary of Connetics. The Exercise Notice
shall be accompanied by payment of the aggregate Exercise Price as to all
Exercised Shares. This Option shall be deemed to be exercised upon receipt by
Connetics of such fully executed Exercise Notice accompanied by such aggregate
Exercise Price.

     No Shares shall be issued pursuant to the exercise of this Option unless
such issuance and exercise complies with Applicable Laws. Assuming such
compliance, for income tax purposes the Exercised Shares shall be considered
transferred to the Optionee on the date the Option is exercised with respect to
such Exercised Shares.

     3. Method of Payment. Payment of the aggregate Exercise Price shall be by
any of the following, or a combination thereof, at the election of the Optionee:

          (a) cash; or

          (b) check; or

          (c) consideration received by Connetics under a cashless exercise
     program implemented by Connetics in connection with the Plan; or

          (d) surrender of other Shares which (i) in the case of Shares acquired
     upon exercise of an option, have been owned by the Optionee for more than
     six (6) months on the date of surrender, and (ii) have a Fair Market Value
     on the date of surrender equal to the aggregate Exercise Price of the
     Exercised Shares; or

          (e) with the Administrator's consent, delivery of Optionee's
     promissory note (the "Note") in the form attached hereto as Exhibit C, in
     the amount of the aggregate Exercise Price of the Exercised Shares together
     with the execution and delivery by the Optionee of the Security Agreement
     attached hereto as Exhibit B. The Note shall bear interest at the
     "applicable federal rate" prescribed under the Code and its regulations at
     time of purchase, and shall be secured by a pledge of the Shares purchased
     by the Note pursuant to the Security Agreement.

     4. Non-Transferability of Option. This Option may not be transferred in any
manner otherwise than by will or by the laws of descent or distribution and may
be exercised during the lifetime of Optionee only by the Optionee. The terms of
the Plan and this Option Agreement shall be binding upon the executors,
administrators, heirs, successors and assigns of the Optionee.

     5. Term of Option. This Option may be exercised only within the term set
out in the Notice of Grant, and may be exercised during such term only in
accordance with the Plan and the terms of this Option Agreement.

     6. Tax Consequences. Some of the federal tax consequences relating to this
Option, as of the date of this Option, are set forth below. THIS SUMMARY IS
NECESSARILY INCOMPLETE, AND THE TAX LAWS AND REGULATIONS ARE SUBJECT TO CHANGE.
THE OPTIONEE SHOULD CONSULT A TAX ADVISER BEFORE EXERCISING THIS OPTION OR
DISPOSING OF THE SHARES.

          (a) Exercising the Option.

             (i) Nonstatutory Stock Option. The Optionee may incur regular
        federal income tax liability upon exercise of a NSO. The Optionee will
        be treated as having received compensation income
                                      E-11
<PAGE>   12

        (taxable at ordinary income tax rates) equal to the excess, if any, of
        the Fair Market Value of the Exercised Shares on the date of exercise
        over their aggregate Exercise Price. If the Optionee is an Employee or a
        former Employee, Connetics will be required to withhold from his or her
        compensation or collect from Optionee and pay to the applicable taxing
        authorities an amount in cash equal to a percentage of this compensation
        income at the time of exercise, and may refuse to honor the exercise and
        refuse to deliver Shares if such withholding amounts are not delivered
        at the time of exercise.

             (ii) Incentive Stock Option. If this Option qualifies as an ISO,
        the Optionee will have no regular federal income tax liability upon its
        exercise, although the excess, if any, of the Fair Market Value of the
        Exercised Shares on the date of exercise over their aggregate Exercise
        Price will be treated as an adjustment to alternative minimum taxable
        income for federal tax purposes and may subject the Optionee to
        alternative minimum tax in the year of exercise. In the event that the
        Optionee ceases to be an Employee but remains a Service Provider, any
        Incentive Stock Option of the Optionee that remains unexercised shall
        cease to qualify as an Incentive Stock Option and will be treated for
        tax purposes as a Nonstatutory Stock Option on the date three (3) months
        and one (1) day following such change of status.

          (b) Disposition of Shares.

             (i) NSO. If the Optionee holds NSO Shares for at least one year,
        any gain realized on disposition of the Shares will be treated as
        long-term capital gain for federal income tax purposes.

             (ii) ISO. If the Optionee holds ISO Shares for at least one year
        after exercise and two years after the grant date, any gain realized on
        disposition of the Shares will be treated as long-term capital gain for
        federal income tax purposes. If the Optionee disposes of ISO Shares
        within one year after exercise or two years after the grant date, any
        gain realized on such disposition will be treated as compensation income
        (taxable at ordinary income rates) to the extent of the excess, if any,
        of the lesser of (A) the difference between the Fair Market Value of the
        Shares acquired on the date of exercise and the aggregate Exercise
        Price, or (B) the difference between the sale price of such Shares and
        the aggregate Exercise Price. Any additional gain will be taxed as
        capital gain, short-term or long-term depending on the period that the
        ISO Shares were held.

          (c) Notice of Disqualifying Disposition of ISO Shares. If the Optionee
     sells or otherwise disposes of any of the Shares acquired pursuant to an
     ISO on or before the later of (i) two years after the grant date, or (ii)
     one year after the exercise date, the Optionee shall immediately notify
     Connetics in writing of such disposition. The Optionee agrees that he or
     she may be subject to income tax withholding by Connetics on the
     compensation income recognized from such early disposition of ISO Shares by
     payment in cash or out of the current earnings paid to the Optionee.

     7. Entire Agreement; Governing Law. The Plan is incorporated in this
Agreement by reference. The Plan and this Option Agreement constitute the entire
agreement of the parties with respect to the subject matter hereof and supersede
in their entirety all prior undertakings and agreements of Connetics and
Optionee with respect to the subject matter hereof, and may not be modified
adversely to the Optionee's interest except by means of a writing signed by
Connetics and Optionee. This agreement is governed by the internal substantive
laws, but not the choice of law rules, of California.

     8. NO GUARANTEE OF CONTINUED SERVICE. OPTIONEE ACKNOWLEDGES AND AGREES THAT
THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE OF THIS AGREEMENT IS
EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF CONNETICS (AND
NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED AN OPTION OR PURCHASING SHARES
UNDER THIS PLAN). OPTIONEE FURTHER ACKNOWLEDGES AND AGREES THAT THIS AGREEMENT,
THE TRANSACTIONS CONTEMPLATED UNDER THIS AGREEMENT AND THE VESTING SCHEDULE SET
FORTH IN THIS AGREEMENT DO NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF
CONTINUED ENGAGEMENT AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY
PERIOD,

                                      E-12
<PAGE>   13

OR AT ALL, AND SHALL NOT INTERFERE WITH OPTIONEE'S RIGHT OR CONNETICS' RIGHT TO
TERMINATE OPTIONEE'S RELATIONSHIP AS A SERVICE PROVIDER AT ANY TIME, WITH OR
WITHOUT CAUSE.

     By your signature and the signature of Connetics' representative below, you
and Connetics agree that this Option is granted under and governed by the terms
and conditions of the Plan and this Option Agreement. Optionee has reviewed the
Plan and this Option Agreement in their entirety, has had an opportunity to
obtain the advice of counsel prior to executing this Option Agreement and fully
understands all provisions of the Plan and Option Agreement. Optionee hereby
agrees to accept as binding, conclusive and final all decisions or
interpretations of the Administrator upon any questions relating to the Plan and
Option Agreement. Optionee further agrees to notify Connetics upon any change in
the residence address indicated below.

<TABLE>
<S>                                                         <C>
OPTIONEE:                                                   CONNETICS CORPORATION

- -----------------------------------------------------       -----------------------------------------------------
Signature                                                   By

- -----------------------------------------------------       -----------------------------------------------------
Print Name                                                  Title

- -----------------------------------------------------
Residence Address

- -----------------------------------------------------
</TABLE>

                                      E-13
<PAGE>   14

                                                                       EXHIBIT A

                             CONNETICS CORPORATION

                               STOCK PLAN (2000)

                                EXERCISE NOTICE

Connetics Corporation
3400 Bayshore Road
Palo Alto, CA 94303

Attention: Secretary

     1. Exercise of Option. Effective as of today,                ,           ,
the undersigned ("Purchaser") hereby elects to purchase           shares (the
"Shares") of the Common Stock of Connetics Corporation (the "Company") under and
pursuant to the Stock Plan (2000) (the "Plan") and the Stock Option Agreement
dated             ,        (the "Option Agreement"). The purchase price for the
Shares shall be $          , as required by the Option Agreement.

     2. Delivery of Payment. Purchaser herewith delivers to Connetics the full
purchase price for the Shares.

     3. Representations of Purchaser. Purchaser acknowledges that Purchaser has
received, read and understood the Plan and the Option Agreement and agrees to
abide by and be bound by their terms and conditions.

     4. Rights as Stockholder. Until the issuance (as evidenced by the
appropriate entry on the books of Connetics or of a duly authorized transfer
agent of Connetics) of the Shares, no right to vote or receive dividends or any
other rights as a stockholder shall exist with respect to the Optioned Stock,
notwithstanding the exercise of the Option. The Shares so acquired shall be
issued to the Optionee as soon as practicable after exercise of the Option. No
adjustment will be made for a dividend or other right for which the record date
is prior to the date of issuance, except as provided in [SECTION 13] of the
Plan.

     5. Tax Consultation. Purchaser understands that Purchaser may suffer
adverse tax consequences as a result of Purchaser's purchase or disposition of
the Shares. Purchaser represents that Purchaser has consulted with any tax
consultants Purchaser deems advisable in connection with the purchase or
disposition of the Shares and that Purchaser is not relying on Connetics for any
tax advice.

     6. Entire Agreement; Governing Law. The Plan and Option Agreement are
incorporated herein by reference. This Agreement, the Plan and the Option
Agreement constitute the entire agreement of the parties with respect to the
subject matter hereof and supersede in their entirety all prior undertakings and
agreements of Connetics and Purchaser with respect to the subject matter hereof,
and may not be modified adversely to

                                      E-14
<PAGE>   15

the Purchaser's interest except by means of a writing signed by Connetics and
Purchaser. This agreement is governed by the internal substantive laws, but not
the choice of law rules, of California.

<TABLE>
<S>                                                <C>

Submitted by:                                      Accepted by:
PURCHASER:                                         CONNETICS CORPORATION
- --------------------------------------------       --------------------------------------------
Signature                                          By
- --------------------------------------------       --------------------------------------------
Print Name                                         Its

Address:                                           Address:
- --------------------------------------------       Connetics Corporation
- --------------------------------------------       3400 West Bayshore Road
                                                   Palo Alto, CA 94303
                                                   --------------------------------------------
                                                   Date Received
</TABLE>

                                      E-15

<PAGE>   1

                                                                     Exhibit 5.1

                                       August 12, 1999



Connetics Corporation
3400 West Bayshore Road
Palo Alto, California 94303

     RE: REGISTRATION STATEMENT ON FORM S-8
         ----------------------------------

Ladies and Gentlemen:

     We have examined the Registration Statement on Form S-8 to be filed by you
with Securities and Exchange Commission on or about August 13, 1999 (the
"Registration Statement") in connection with the registration under the
Securities Act of 1933, as amended, of the 1994 Stock Plan (as to 500,000
shares), of the 1995 Director Option Plan (as to 150,000 shares), of the 1998
Supplemental Stock Plan (as to 274,250 shares), and of the 2000 Stock Plan (as
to 600,000 shares)(collectively, the "Option Shares" and the "Plans"). As legal
counsel for Connetics Corporation, we have examined the proceedings taken and
are familiar with the proceedings proposed to be taken by you in connection with
the issuance and sale of Option Shares pursuant to the Plans.

     It is our opinion that the Option Shares, when issued and sold in the
manner described in the Plans and pursuant to the agreement that accompanies
each grant under the Plans, will be legally and validly issued, fully-paid and
non-assessable.

     We consent to the use of this opinion as an exhibit to the Registration
Statement, and further consent to the use of our name wherever appearing in the
Registration Statement and any amendments thereto.

                                       Sincerely yours,

                                       WILSON SONSINI GOODRICH & ROSATI
                                       A Professional Corporation


                                       /s/ J. CASEY McGLYNN

<PAGE>   1

                                                                    Exhibit 23.2

                CONSENT OF ERNST & YOUNG LLP INDEPENDENT AUDITORS

     We consent to the incorporation by reference in this Registration Statement
(Form S-8), pertaining to the 1994 Stock Plan, the 1995 Directors' Stock Plan,
the 1998 Supplemental Stock Plan, and the 2000 Stock Plan of Connetics
Corporation and to the incorporation by reference of our report dated January
13, 1999 with respect to the financial statements of Connetics Corporation
included in the its Annual Report (Form 10-K) for the year ended December 31,
1998 filed with the Securities and Exchange Commission.



                                       ERNST & YOUNG LLP

                                       /s/ Ernst & Young LLP
                                       --------------------------

Palo Alto, California
August 12, 1999


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