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<TABLE> <S> <C>
<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY INFORMATION EXTRACTED FROM DEPOMED, INC.'S
BALANCE SHEET (UNAUDITED) FOR JUNE 30, 2000 AND STATEMENT OF INCOME (UNAUDITED)
FOR THE THREE AND SIX MONTHS ENDED JUNE 30, 2000 AND IS QUALIFIED IN ITS
ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<S> <C> <C>
<PERIOD-TYPE> 3-MOS 6-MOS
<FISCAL-YEAR-END> DEC-31-2000 DEC-31-2000
<PERIOD-START> APR-01-2000 JAN-01-2000
<PERIOD-END> JUN-30-2000 JUN-30-2000
<CASH> 2,621,286 2,621,286
<SECURITIES> 2,999,455 2,999,455
<RECEIVABLES> 585,562 585,562
<ALLOWANCES> 0 0
<INVENTORY> 0 0
<CURRENT-ASSETS> 121,550 121,550
<PP&E> 1,443,212 1,443,212
<DEPRECIATION> (579,994) (579,994)
<TOTAL-ASSETS> 7,484,827 7,484,827
<CURRENT-LIABILITIES> 1,697,272 1,697,272
<BONDS> 0 0
0 0
12,386,000 12,386,000
<COMMON> 19,731,149 19,731,149
<OTHER-SE> 0 0
<TOTAL-LIABILITY-AND-EQUITY> 7,484,827 7,484,827
<SALES> 0 0
<TOTAL-REVENUES> 585,562 961,980
<CGS> 0 0
<TOTAL-COSTS> 0 0
<OTHER-EXPENSES> 2,210,099 3,985,453
<LOSS-PROVISION> 0 0
<INTEREST-EXPENSE> 16,013 33,712
<INCOME-PRETAX> (2,179,212) (3,826,666)
<INCOME-TAX> 0 0
<INCOME-CONTINUING> (2,179,212) (3,826,666)
<DISCONTINUED> 0 0
<EXTRAORDINARY> 0 0
<CHANGES> 0 0
<NET-INCOME> (2,179,212) (3,826,666)
<EPS-BASIC> (0.33) (0.59)
<EPS-DILUTED> (0.33) (0.59)
</TABLE>
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