CHIREX INC
8-K, 1997-11-17
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K

                                 CURRENT REPORT
                         PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

DATE OF REPORT (DATE OF 
  EARLIEST EVENT REPORTED): NOVEMBER 14, 1997 (OCTOBER 31, 1997)


                                   CHIREX INC.
             (Exact name of registrant as specified in its charter)


           DELAWARE                    0 - 27698                 04-3296309
(State or other jurisdiction of  Commission File number       (I.R.S. Employer 
incorporation or organization)                               Identification No.)

         300 Atlantic Street
              Suite 402
        Stamford, Connecticut                                      06901
(Address of principle executive office)                         (Zip Code)

                                 (203) 351-2300
              (Registrant's telephone number, including area code)
<PAGE>   2

ITEM 2. ACQUISITION OR DISPOSITION OF ASSETS

On October 31, 1997, ChiRex Inc. (the "Company" or "ChiRex") and Glaxo Wellcome
plc ("Glaxo Wellcome or Glaxo") announced that ChiRex completed its purchase of
Glaxo Wellcome's FDA cGMP pharmaceutical production facility at Annan, Scotland
("Annan"). Glaxo Wellcome has received approximately $66 million ((pounds)40
million) for the facility plus an additional payment for certain working capital
of approximately $1.6 million (approximately (pounds)1 million) and ChiRex will
initiate the manufacture of certain pharmaceutical intermediates and active
ingredients under a five-year contract with Glaxo valued at approximately $450
million. The transaction will be accounted for as a purchase.

On July 7, 1997, ChiRex announced the signing of a letter of intent with Glaxo
Wellcome plc to acquire Glaxo Wellcome's FDA cGMP pharmaceutical production
facility at Annan, Scotland. As part of the proposed agreement, Glaxo Wellcome
would award the Company a five-year contract to supply certain pharmaceutical
intermediates and active ingredients worth approximately $450 million. A
definitive Asset Purchase Agreement and Supply Agreement were signed by the
Company and Glaxo Welcome on September 23, 1997, on essentially the same terms
contained in the letter of intent with the closing occurring no later than
November 15, 1997. 

Under the Asset Purchase Agreement, ChiRex purchased all of the buildings, land
and equipment at the 154-acre Annan, Scotland property, encompassing three main
production facilities plus certain working capital. Under the Supply Agreement,
ChiRex will continue to manufacture most of the products currently made at Annan
and plans to invest (pounds)20 million (approximately $31 million) over five
years to accommodate newly contracted products and to modify the facility for
general purpose pharmaceutical fine chemical manufacturing.

To finance the acquisition and provide for the general cash requirements of the
business, a subsidiary of the Company entered into a senior secured term-loan
and revolving credit agreement on October 29, 1997, with Bankers Trust Company
allowing it to borrow up to (pounds)62 million (approximately $100 million) for
a five-year period. The credit facility is comprised of a (pounds)40 million
(approximately $65 million) term loan and a (pounds)22 million (approximately
$35 million) revolving credit facility each bearing interest at LIBOR plus 1%.
The term-loan facility is repayable in nine equal semi-annual installments
beginning in late 1998 and also provides for annual mandatory pre-payments from
excess cashflow as defined in the credit agreement. Borrowings under the credit
facility are secured by the real and personal property of and guaranteed by the
Company and its subsidiaries. The credit agreement contains normal and customary
financial covenants and limitations on indebtedness, dividends, capital
expenditures and certain other transactions. The Company's existing bank
revolving credit facility was repaid and terminated upon signing of the new
credit facility.

ChiRex is a Contract Manufacturing Organization serving the outsourcing needs of
the pharmaceutical industry through its extensive pharmaceutical fine chemical
manufacturing, process development capabilities and proprietary chiral
technologies. The Company supports and supplements the in-house development and
manufacturing capabilities of its pharmaceutical and biotechnology customers
with a broad range of fully-integrated services, accelerating the time from drug
discovery to commercialization. ChiRex currently produces over 50 products in
its two world-class, FDA cGMP manufacturing facilities in Dudley,
Northumberland, England and in Annan, Scotland. ChiRex holds over 50 patents and
patent applications in the field of chiral chemistry.

Any statements contained in this Current Report on Form 8-K that relate to
future plans, events or performance, are forward-looking statements that involve
risks and uncertainties, including, but not limited to, product development and
market acceptance risks, product manufacturing risks, the impact of competitive
products and pricing, the results of current and future licensing and other
collaborative relationships, the results of financing efforts, developments
regarding intellectual property rights and litigation, risks of product
non-approval or delays or post-approval reviews by the FDA or foreign regulatory
authorities, and other risks identified in the ChiRex Inc.'s Securities and
Exchange Commission filings. Actual results, events or performance may differ
materially. Readers are cautioned not to place 


                                       1
<PAGE>   3

undo reliance on these forward-looking statements, which speak only as the date
hereof. ChiRex undertakes no obligation to publicly release the results of any
revisions to these forward-looking statements that may be made to reflect events
or circumstances after the date hereof or to reflect the occurrence of
unanticipated events.

ITEM 7 - FINANCIAL STATEMENTS AND EXHIBITS

(a) Financial Statements of the Business Acquired. 

Audited financial statements for the Annan Manufacturing Site of Glaxo
Operations UK Limited for the years ended December 31, 1994, 1995 and 1996
required by Item 7(a) of this Current Report on Form 8-K will be filed with the
Securities and Exchange Commission as soon as possible, but in any event on or
prior to January 13, 1998.

(b) Pro Forma Financial Statements.

Unaudited pro forma combined balance sheets and statements of operations of the
Company and the Annan Manufacturing Site of Glaxo Operations UK Limited required
by Item 7(b) of this Current Report on Form 8-K will be filed with the
Securities and Exchange Commission as soon as possible, but in any event on or
prior to January 13, 1998.

(c) Exhibits.

The exhibits listed in the accompanying Exhibit Index are filed pursuant to Item
7(c) of this Current Report on Form 8-K.


SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                                   CHIREX INC.


Date: November 14, 1997                            By: /s/ Michael A. Griffith
                                                      --------------------------
                                                   Michael A. Griffith
                                                   Chief Financial Officer
                                                   and Secretary


                                       2
<PAGE>   4

EXHIBIT INDEX

Exhibit Number                                     Description
- --------------                                     -----------

2.1*                                    Asset Purchase Agreement between ChiRex
                                        Inc. and Glaxo Wellcome plc

4.1                                     Facilities Agreement between ChiRex
                                        (Holdings) Limited. and Bankers Trust
                                        Company

4.2                                     Pledge Agreement between ChiRex Inc. and
                                        Bankers Trust Company

10.1*                                   Supply Agreement between ChiRex Inc. and
                                        Glaxo Wellcome plc

99.1                                    ChiRex Inc. press release dated October
                                        31, 1997

- ----------
* Certain portions of this exhibit have been omitted and are subject to a
confidential treatment request. The omitted portions have been filed separately
with the Securities and Exchange Commission.


                                       3

<PAGE>   1

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.

                                                              September 23, 1997


                             (1) GLAXO GROUP LIMITED

                                       and

                           (2) CHIREX (ANNAN) LIMITED


                   ------------------------------------------

                                    AGREEMENT

                        for the sale and purchase of the
                   Business and Assets of Glaxo Group Limited
                        operated from its site at Annan,
                               Dumfries, Scotland

                   ------------------------------------------
<PAGE>   2

                                      INDEX

CLAUSE

1.   DEFINITIONS AND INTERPRETATION..........................................  1

2.   SALE AND PURCHASE OF BUSINESS AND ASSETS................................ 12

3.   PURCHASE PRICE.......................................................... 13

4.   CONDITIONS.............................................................. 13

5.   PERIOD BEFORE COMPLETION................................................ 16

6.   COMPLETION.............................................................. 17

7.   REIMBURSEMENT OF COSTS.................................................. 19

8.   COMPLETION STATEMENT.................................................... 20

9.   CONTRACTS............................................................... 21

10.  CREDITORS AND LIABILITIES............................................... 22

11.  EMPLOYEES............................................................... 26

12.  PENSIONS................................................................ 28

13.  APPORTIONMENT........................................................... 28

14.  WARRANTIES.............................................................. 29

15.  RIGHT TO RESCIND........................................................ 31

16.  POST COMPLETION OBLIGATIONS............................................. 32

17.  VALUE ADDED TAX......................................................... 34

18.  CAPITAL GOODS SCHEME.................................................... 35

19.  FURTHER ASSURANCE....................................................... 35

20.  DISPUTE RESOLUTION...................................................... 36

21.  SECONDMENT.............................................................. 37
<PAGE>   3

22.  ANNOUNCEMENTS........................................................... 38

23.  COSTS................................................................... 38

24.  SUCCESSORS AND ASSIGNMENT............................................... 38

25.  ENTIRE AGREEMENT........................................................ 38

26.  TIME OF THE ESSENCE..................................................... 39

27.  NOTICES................................................................. 39

28.  AGREEMENT CONTINUES IN FORCE............................................ 39

29.  SEVERABILITY............................................................ 39

30.  WAIVER.................................................................. 40

31.  VARIATIONS.............................................................. 40

32.  COUNTERPARTS............................................................ 40

33.  FUNDING................................................................. 40

34.  GOVERNING LAW........................................................... 40


SCHEDULE 1................................................................... 42
     Apportionment of Purchase Price......................................... 42

SCHEDULE 2................................................................... 44
     The Property............................................................ 44

SCHEDULE 3................................................................... 48
     Terms and Conditions of Sale of the Property............................ 48

SCHEDULE 4................................................................... 53
     Pensions................................................................ 53

     Definitions............................................................. 53

     Calculation of the Transfer Requirement................................. 59

     Payment of the Transfer Requirement and Provision of
     Benefits................................................................ 60

     Additional Voluntary Contributions...................................... 63
<PAGE>   4

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


SCHEDULE 5................................................................... 67
     Warranties.............................................................. 67

SCHEDULE 6...................................................................103
     Limitations to Vendor's Liability.......................................103
<PAGE>   5

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


Agreed Form documents*


Annexures*
<PAGE>   6

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


*These documents have been omitted from the filing because the Registrant does
not believe them material to an investment in its Common Stock. The documents
will be furnished supplementally to the Commission upon request.
<PAGE>   7

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.

THIS AGREEMENT is made September 23, 1997

BETWEEN:

(1)   GLAXO GROUP LIMITED (registered number 305979) whose registered office is
      at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN
      (the "Vendor"),

(2)   CHIREX (ANNAN) LIMITED (registered number 3417229) whose registered office
      is at Dudley, Cramlington, Northumberland NE23 7QG (the "Purchaser")

WHEREAS

The Vendor carries on the Business and the Vendor has agreed to sell and the
Purchaser has agreed to purchase the Business and the Assets as a going concern
for the consideration and otherwise upon the terms and conditions set out in
this agreement.

IT IS HEREBY AGREED:

1.    DEFINITIONS AND INTERPRETATION

      1.1   In this agreement the following words and expressions shall (except
            where the context otherwise requires) have the following meanings:

            "Access Agreement" means the access agreement between Dumfries and
            Galloway Regional Council and a company within the Vendor's Group
            dated 8 June 1979 and 17 July 1979 and recorded in the Division of
            the General Register of Sasines applicable to the County of Dumfries
            on 21 September 1979;

            "Accounts" means the audited financial statements of the Annan
            manufacturing site of GWO for each of the three consecutive
            accounting reference periods ended on 31 December 1994, 31 December
            1995 and 31 December 1996 respectively and the audited financial
            statements of the Annan manufacturing site of GWO for the period
            from 31 December 1996 to 


                                       1
<PAGE>   8

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            Completion and the financial statements to be produced pursuant to
            clause 16.2;

            "Accounts Date" means the date as at which the Accounts were
            respectively prepared;

            "Assets" means, the Contracts, the Equipment, the Fixed Plant, the
            Goodwill, the Intellectual Property, the Property, the Stock and the
            Work in Progress; 

            "Body Corporate" means any body corporate other than a company
            incorporated under the Companies Acts;

            "Business" means the business of the manufacture and sale of
            pharmaceutical intermediates carried on at the date hereof at the
            Property by the Vendor;

            "Business Day" means a day other than a Saturday or Sunday on which
            banks are open for business in London;

            "Cash" means the cash in hand and at bank of the Vendor in respect
            of the Business at the Completion Date;

            "Companies Acts" means the 1985 Act and the 1989 Act;

            "Company" means (i) for the purposes of paragraph 1.3.1 of Schedule
            3 a company incorporated under the Companies Acts and/or a Friendly
            Society and/or an Industrial and Provident Society and/or a foreign
            company and (ii) for the purposes of paragraphs 1.3.2 and 1.3.4 of
            Schedule 3, a company incorporated under the Companies Acts;

            "Completion" means completion of the sale and purchase of the Assets
            in accordance with Clause 6;

            "Completion Date" means 5 pm on the date on which Completion takes
            place;


                                       2
<PAGE>   9

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Computer Systems" means the computer systems used by or for the
            benefit of the Business and which are located on the Property or
            computer processors associated and peripheral equipment computer
            programs, technical and other documentation and data entered into or
            created by the Vendor and used by or for the benefit of the Business
            from time to time;

            "Conditions" means the conditions contained or referred to in Clause
            4;

            "Confidential Information" means information concerning or relating
            to property owned or used in connection with the Business in the
            nature of know-how, trade secrets, technical processes, and any
            other matters concerning the business, affairs or finances of the
            Business (however stored) (details of which are not in the public
            domain);

            "Contracts"

            (i) means those contracts entered into by or on behalf of the Vendor
            in connection with the Business for the purchase of raw materials
            and intermediates by the Vendor details of which are set out in the
            list in agreed terms headed "Purchase Contracts";

            (ii) means such other written contracts (but excluding the Lease
            Contracts) entered into by or on behalf of the Vendor in connection
            with the Business details of which are set out in the list in agreed
            terms headed "Other Contracts";

            and in each case which shall be subsisting but uncompleted (both
            those part performed and those not yet commenced) on the Completion
            Date;

            "Deeds and Documents" means those deeds and documents relating to
            the Property identified in the list in agreed terms headed "Deeds
            and Documents";


                                       3
<PAGE>   10

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Defective" means cannot be used for its intended purpose in its
            current form or used to produce good quality material without undue
            expense being incurred in relation to it;

            "Disclosed Scheme(s)" means the retirement benefits schemes details
            of which are set out in Schedule 4 Part 1;

            "Disclosure Letter" means the letter of even date with this
            agreement from the Vendor to the Purchaser in agreed terms relating
            to the Warranties together with any documents annexed thereto;

            "Disposition" means a Disposition of the Property with absolute
            warrandice in the form annexed hereto (Annex 6) to be granted by GWO
            to the Purchaser on Completion;

            "Employees" means those employees of the Vendor whose employment is
            to be transferred to the Purchaser and whose names and details of
            employment are set out in the list in agreed terms headed
            "Employees";

            "Employment Letter" a letter from the Vendor to the Purchaser
            relating to the Employees;

            "Encumbrance" means a mortgage, equity, charge, lien, claim, third
            party right standard security, floating charge or other encumbrance;

            "Environment" means all or any of the following media namely: the
            air (including without limitation the air within buildings and the
            air within other natural or manmade structures above or below
            ground), water and land and any living organisms or systems
            supported by those media;

            "Environmental Laws" means all European Community or Union
            Regulations, directives and statutory decisions, all statutes and
            subordinate legislation, 


                                       4
<PAGE>   11

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            all regulations, orders and ordinances including but without
            limitation the Environment Act 1995, the Radioactive Substances Act
            1993, the Planning (Hazardous Substances) (Scotland) Act 1997, the
            Control of Pollution Act 1974, and the Environment Act 1990 and the
            Sewerage (Scotland) Act 1968 together with Part IIA Environmental
            Protection Act 1990, Sections 161A - 161D Water Resources Act 1991
            and Sections 46A-D of the Control of Pollution Act 1974 the Private
            Water Supply (Scotland) Regulations and all subordinate legislation
            or guidance having effect thereunder and all consents, permits,
            authorizations and local laws and bye-laws, all judgments, decrees,
            orders, instructions, demands or awards of any competent authority
            in each of the foregoing cases which are directly applicable in the
            United Kingdom or any parts thereof and which concern the protection
            of the Environment;

            "Equipment" means all the loose plant, equipment, engineering
            supplies, machinery, tools, motor vehicles, furniture, trade
            utensils and other chattels owned or used in connection with the
            Business at the Completion Date located at the Property (or which
            are leased or hired under the terms of any of the Lease Contracts)
            including but without limitation those items set out in the list in
            agreed terms headed "Equipment";

            "Excluded Assets" means the items listed at Schedule 1 Part 2;

            "Excluded Employees" means those employees of the Vendor (previously
            employed within the Business) whose employment is not to be
            transferred to the Purchaser hereunder details of whom are set out
            in the list in agreed terms headed "Excluded Employees";

            "External Costs" means the external costs including labour costs
            incurred by the Vendor directly in connection with the design and
            development works 


                                       5
<PAGE>   12

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            which the Purchaser agrees or has agreed is necessary at the
            Property to facilitate the production of ****;

            "Finished Products" means any products manufactured by the Vendor or
            any member of the Vendor's Group in connection with the Business;

            "Fixed Plant" means the fixed plant owned or used in connection with
            the Business and physically attached to the Property including,
            without limitation, that identified in the list in agreed terms
            headed "Fixed Plant";

            "Foreign Company" means any legal person, other than a natural
            person, incorporated elsewhere than in Great Britain;

            "Glaxo Wellcome plc Letter" means a letter in agreed terms from
            Glaxo Wellcome plc relating to the transfer of the Employees";

            "Grazing Lease" means the grazing lease entered into between a
            company within the Vendor's Group and Messrs J.M. & J. Goldie dated
            3 March 1997;

            "Goodwill" means the goodwill of the Business excluding any part
            thereof which is an Excluded Asset;

            "GWO" means Glaxo Operations UK Limited (registered number 711851)
            which trades under the name Glaxo Wellcome Operations;

            "Hoddam" means Hoddam Contracting Company Limited having its
            registered office at Hoddam Road, Ecclefechan;

            "Hoddam Agreement" means the agreement for the supply of water to
            Hoddam constituted by letter dated 14 January 1997 from GWO to
            Hoddam and 


                                       6
<PAGE>   13

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            Hoddam's endorsed acceptance thereof dated 4 February 1997;

            "Information Technology Services Agreement" means the agreement in
            agreed terms between GWO and the Purchaser relating to the provision
            of information technology support by GWO to the Purchaser;

            "Intellectual Property" means patents, inventions, know-how, trade
            secrets and other confidential information, registered designs,
            copyrights, design rights, rights affording equivalent protection to
            copyright and design rights, topography rights, trade marks, service
            marks, business names, trade names, moral rights, registration of an
            application to register any of the aforesaid items, rights in the
            nature of any of the aforesaid items in any country, rights in the
            nature of unfair competition rights and rights to sue for
            passing-off in all such cases relating exclusively to the Business
            but excluding any of the foregoing which relates to any Excluded
            Asset;

            "IPC Authorization" means the Integrated Pollution Control
            Authorizations issued in respect of the Business under Section 6 of
            the Environmental Protection Act 1990 being authorization number
            IPC/063/1994, IPC/011/1994, IPC/012/1994; and IPC/058/93;

            "Keeper" means the Keeper of the Registers of Scotland;

            "Land Register" means the Land Register of Scotland;

            "Last Actuarial Valuation" means the last actuarial valuation or
            funding review of the Disclosed Scheme received (whether in draft or
            final form) prior to the date of this agreement;

            "Lease Contracts" means the lease and hire purchase agreements
            entered into by or on behalf of GWO in 


                                       7
<PAGE>   14

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            connection with the Business and subsisting at the Completion Date
            details of which are set out in the list in agreed terms headed
            "Lease Contracts";

            "Management Accounts" means the unaudited balance sheet and profit
            and loss account of the Annan manufacturing site of GWO for the
            monthly periods ending respectively 31 July 1997, 31 August 1997,
            and 30 September 1997;

            "Obsolete" means cannot be used for the purpose intended in
            connection with the Business;

            "Parties" means the parties to this agreement;

            "Pensions Warranties" means the warranties contained in Schedule 4
            Part 3;

            "Pipeline" means the pipeline for the supply of water from the River
            Annan to within the Property and all pumps, valves, manholes,
            inspection chambers and associated plant and equipment and
            apparatus, the right to part of which is governed by the Servitudes
            and the weir in the River Annan immediately downstream from the
            Pumphouse, the line of the Pipeline being shown on the plan annexed
            to this agreement headed "Plan A" (Annex 1) including without
            prejudice to the generality the Pumphouse and the Pumping Station;

            "Property" means the heritable property and servitude rights
            described in Schedule 2 and any parts thereof;

            "Pumphouse" means the pumphouse, pump and intake pipe and other
            plant and equipment constructed on the subjects described (In the
            Third Place) (FIRST) in Schedule 2;

            "Pumping Station" means the pumping station and pumps and other
            equipment constructed on the 


                                       8
<PAGE>   15

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            subjects described (In the Third Place) (SECOND) in Schedule 2;

            "Purchase Price" means the aggregate amount payable by the Purchaser
            for the Business and the Assets as set out in Clause 3;

            "Purchaser's Accountants" means Arthur Andersen of Pearl Assurance
            House, 7 New Bridge Street, Newcastle Upon Tyne NE1 8BQ;

            "Purchaser's Group" means the Purchaser, any parent company of the
            Purchaser and any company which, in relation to the Purchaser and/or
            any parent company of the Purchaser, is a subsidiary undertaking
            from time to time;

            "Purchaser's Property Solicitors" means Brodies of 15 Atholl
            Crescent, Edinburgh EH3 8HA;

            "Purchaser's Solicitors" means Dibb Lupton Alsop of 117 The Headrow,
            Leeds LS1 5JX;

            "Records" means a list of all suppliers, books and records, whether
            stored on hard copy or on computer and computer programmes, designs,
            drawings, plans and specifications and other technical matter in
            relation to the Business together with any plates, blocks, negatives
            and other like material relating thereto other than the Retained
            Records and other than any of the foregoing which relate to Excluded
            Assets;

            "Regulations" means the Transfer of Undertakings (Protection of
            Employment) Regulations 1981 as amended by the Collective
            Redundancies and Transfer of Undertakings (Protection of Employment)
            Amendment Regulations 1995;

            "Relevant Claim" means any claim by the Purchaser relating to a
            breach of the Warranties;


                                       9
<PAGE>   16

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Retained Records" means those records of or relating to the
            Business details of which are set out in the list is agreed terms
            headed "Retained Records";

            "Secondment Letter" means the letter in agreed terms between GWO and
            the Purchaser relating to the secondment of certain of the Employees
            by the Purchaser to a Vendor Group Company;

            "SEPA" means the Scottish Environmental Protection Agency;

            "Secrecy Agreement" means the secrecy agreement between Glaxo
            Wellcome plc and Chirex Limited dated 30 May 1997 entered into in
            contemplation of the sale of the Business and Assets under this
            agreement;

            "Servitudes" shall have the meaning given in Schedule 2;

            "SSAP" and "FRS"" means respectively a Statement of Standard
            Accounting Practice or Financial Reporting Standard in force at this
            date as made or adopted by the Accounting Standards Board Limited;

            "Shelf-Life" means the period during which intermediates and raw
            materials may properly be used;

            "Stock" means the stock in trade of unfinished goods, intermediates,
            raw materials, fuel, of the Vendor for the purposes of the Business
            as at the Completion Date (including items which although supplied
            to the Vendor under reservation of title by the suppliers are under
            the control of the Vendor);

            "Subjects" shall have the meaning given in Schedule 2;


                                       10
<PAGE>   17

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "subscribed" means in relation to any document, that such document
            is validly subscribed so that the document shall be presumed to have
            been subscribed by the grantor of it for the purposes of Sections 3
            and/or 7 of, and/or Schedule 2 to, the Requirements of Writing
            (Scotland) Act 1995;

            "Supply Agreement" means the agreement in agreed terms between GWO
            and the Purchaser relating to the supply of products by the
            Purchaser to GWO;

            "Tax" means all forms of taxation, duty, levy, charges, and
            withholdings, or social security contribution and any fine, penalty,
            or interest in respect thereof;

            "Taxes Act" means the Income and Corporation Taxes Act 1988;

            "VAT" means Value Added Tax;

            "Vendor's Accountants" means Coopers & Lybrand of Plumtree Court
            London;

            "Vendor's Group" means the Vendor, any parent company of the Vendor
            and any company which, in relation to the Vendor and/or any parent
            company of the Vendor is a subsidiary undertaking from time to time;

            "Warranties" means the representations, warranties and undertakings
            on the Vendor's part contained or referred to in Clause 14 and
            Schedule 5 and including the Pensions Warranties;

            "Water Abstraction Consents" means the consents to the abstraction
            of water from the River Annan which are detailed in the assignation
            thereof the form of which is annexed hereto (Annex 2);


                                       11
<PAGE>   18

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Water Supply" means the taking of water from the River Annan by the
            Pipeline;

            "Work in Progress" means work in process of the Vendor for the
            purposes of the Business as at the Completion Date ;

            "1979 Act" means the Land Registration (Scotland) Act 1979;

            "1985 Act" means the Companies Act 1985; and

            "1989 Act" means the Companies Act 1989.

      1.2   Any reference in this agreement to any provision of any Act of
            Parliament shall include reference to any subordinate legislation
            (as defined in the Interpretation Act 1978) made pursuant thereto
            and shall be deemed (unless otherwise expressly provided) to be a
            reference to such Act of Parliament or subordinate legislation as
            amended, modified or re-enacted (whether before or after the date
            hereof) and any reference to any provision of any such Act of
            Parliament or subordinate legislation shall also include where
            appropriate any provision of which it is a re-enactment (whether
            with or without modification).

      1.3   In this agreement words incorporating the masculine gender only
            include the feminine and neuter genders and words incorporating the
            singular number only include the plural and vice versa.

      1.4   Unless otherwise stated references to Clauses, sub-clauses and
            Schedules are references to Clauses and sub-clauses of and Schedules
            to this agreement. The Schedules form part of this agreement.


                                       12
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      1.5   The Index and clause headings are for ease of reference only and do
            not affect the construction or interpretation of this agreement.

      1.6   References to persons shall include bodies corporate, unincorporated
            associations and partnerships.

      1.7   References to the parties hereto include their respective successors
            in title, assigns and legal personal representatives.

      1.8   A body corporate shall be deemed to be associated with another body
            corporate if it is a holding company of, or a subsidiary of, or a
            subsidiary of a holding company of, that other body corporate and a
            person shall be deemed to be connected with another if that person
            is so connected within the meaning of Section 839 of the Taxes Act.

      1.9   Where a document is referred to in this agreement as being "in
            agreed terms", it shall be in the form agreed by the parties to this
            agreement and initialed by or on behalf of them for identification.

      1.10  Where any statement is qualified by the expression "to the best of
            the knowledge information and belief of the Vendor" or "so far as
            the Vendor is aware" or any similar expression there shall be deemed
            to be included after such statement the words "after careful
            consideration and having made appropriate enquiry of relevant
            persons currently in the employment of any company in the Vendor
            Group and the following professional advisers; Sackers, the Vendor's
            Accountants, Dundas & Wilson and the knowledge of the Vendor shall
            be deemed to include the knowledge of each of the companies within
            the Vendor's Group.


                                       13
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


2.    SALE AND PURCHASE OF BUSINESS AND ASSETS

      2.1   The Vendor shall sell with full title guarantee (save for the
            Property)and the Purchaser shall purchase the Business as a going
            concern and all of the Assets free from all Encumbrances as at the
            Completion Date.

      2.2   The Property shall be transferred in accordance with the terms and
            subject to the conditions set out in Schedule 3.

      2.3   There shall be excluded from the sale and purchase hereby agreed
            upon the Excluded Assets and nothing herein contained shall operate
            so as to impose upon the Purchaser any obligations or liabilities in
            respect of any other assets or liabilities of the Vendor except as
            specifically provided in this agreement.

3.    PURCHASE PRICE

      3.1   The Purchase Price payable by the Purchaser for the Business and the
            Assets shall be the aggregate of:

            3.1.1 the sum of (pounds)40,000,000 (forty million pounds) which sum
                  shall be paid on the Completion Date; and

            3.1.2 the sum agreed or determined in accordance with Clause 8
                  provided always that in no circumstances shall this sum exceed
                  (pounds)1,000,000 (one million pounds) and which sum shall be
                  paid on the Completion Date or, if such sum has not been
                  agreed or determined on the Completion Date, within 7 days of
                  such agreement or determination.

      3.2   The Purchase Price shall be apportioned (subject to adjustment in
            accordance with Clause 8) among the Assets as set out in Schedule 1.

4.    CONDITIONS


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      4.1   The sale and purchase of the Business and the Assets under this
            agreement is in all respects conditional upon:-

            4.1.1 the Purchaser being satisfied that there is a secure and
                  adequate supply of water to the Property for the purposes of
                  the Business including satisfactory results of a triangulation
                  survey (to be verified by the Purchaser's environmental
                  consultants) at the Property to establish the suitability of
                  ground water resource and the availability of at least 500,000
                  gallons of water a day which is not contaminated by salt and
                  is of an appropriate quality to be used in the Business and an
                  independent estimate of the cost and timing of sinking the
                  production well and a letter of intent from SEPA confirming
                  their consent to the construction of a pumping well on the
                  Property and the extraction from that well of up to 500,000
                  gallons of water per day for use in the Business and a letter
                  from the local planning authority confirming either that the
                  sinking of a production well would not require planning
                  permission, or (if it does) that planning consent would be
                  granted and a letter from the appropriate authority confirming
                  the availability of a public supply of water to the Property
                  and indicating the capacity of such supply and an estimate of
                  the cost, feasibility and timing of constructing a pipeline to
                  the Property and agreement between the Parties of the works to
                  be undertaken to secure such supplies, it being acknowledged
                  that the Vendor's liability to pay one half of the cost of
                  such works (set out in Clause 16.1) should be limited to an
                  amount to be agreed by the Parties;


                                       15
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            4.1.2 the board of directors of Chirex Inc voting in favor of making
                  the acquisition of the Business and the Assets;

            4.1.3 the Purchaser and the Vendor agreeing proposals regarding the
                  arrangements with Hoddam relating to Hoddam's rights to
                  extract water from the Pipeline, including the possible
                  termination of the Hoddam Agreement, it being acknowledged by
                  the Vendor that it may be appropriate as part of such
                  proposals that the Vendor grant the Purchaser an indemnity in
                  respect of any liabilities, or loss of rights of the Property
                  to extract water which such proposals might give rise to;

            4.1.4 the Purchaser being reasonably satisfied with the current
                  estimates of the Vendor in respect of any works, modification
                  or remedial action required in connection with the variation
                  of the existing IPC Authorizations or obtaining new IPC
                  Authorizations or expenditure otherwise required in respect of
                  the incinerator in excess of (pounds)650,000 it being
                  acknowledged that any increase in operating levels following
                  Completion would not be taken into account in assessing such
                  expenditure and that it may be appropriate for the Vendor to
                  give an indemnity in respect of such expenditure should the
                  existing estimates be insufficient;

            4.1.5 the Purchaser receiving satisfactory confirmation from the
                  Vendor that a manufacturing licence pursuant to the Medicines
                  Act 1968 and the Medicines Act 1971 is not required for the
                  operation of the Business;


                                       16
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            4.1.6 approval of third parties to transfer of contracts/licences;

            4.1.7 the Purchaser being satisfied with the results of any
                  outstanding due diligence enquiries which have been raised in
                  writing by or on behalf of the Purchaser prior to the date of
                  this agreement.

      4.2   The Vendor shall save in respect of clause 4.1.1 use all reasonable
            endeavours with the Purchaser's full assistance to procure that each
            of the conditions set out in Clause 4.1 are satisfied as soon as
            possible, (it being the intention that all such conditions are
            satisfied by 15 October 1997.)

      4.3   In the event of any of the conditions in Clause 4.1 not being
            satisfied or waived in writing by the Purchaser by 15 November 1997
            then the provisions of this agreement, (save for Clauses 21 and 22
            which shall continue in full force and effect) shall (unless the
            Parties otherwise agree in writing) be null and void and of no
            further effect and the Parties shall be released from their
            respective obligations under this agreement. For the avoidance of
            doubt the Secrecy Agreement shall continue to apply between the
            parties thereto.

5.    PERIOD BEFORE COMPLETION

      5.1   The Vendor undertakes that during the period from the date of this
            agreement until the Completion Date it will procure that the
            Business is carried on in substantially the same manner as
            heretofore, so as to maintain the same as a going concern and
            without prejudice to the generality of the foregoing (unless the
            Purchaser shall previously have agreed otherwise in writing) the
            Vendor will procure that it or (as appropriate) GWO will in relation
            to the Business:-


                                       17
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            5.1.1 not enter into any contract or commitment of an unusual nature
                  or which is other than in the ordinary course of business;

            5.1.2 not institute changes in management policy of a significant
                  nature;

            5.1.3 not purchase stock, raw materials, or intermediates of a kind
                  or in quantities other than as may be reasonably necessary for
                  the operation of the Business in the ordinary course and so as
                  to maintain quantities of stock, raw materials and
                  intermediates consistent with the previous operation of the
                  Business;

            5.1.4 not terminate the employment of any of the Employees or alter
                  any existing term of their employment or engage more
                  employees;

            5.1.5 not do or suffer to be done any act or thing which may
                  immediately or in the future adversely affect the Goodwill;

            5.1.6 not enter into any agency, distribution, advertising,
                  maintenance or other similar contract;

            5.1.7 consult the Purchaser prior to taking action in relation to
                  any matters of importance in connection with the Business;

            5.1.8 allow the Purchaser and its representatives reasonable access
                  to the Property and to the books, documents, files and records
                  of the Business on prior notice and subject to the observance
                  by the Purchaser of the site procedures in operation at the
                  Property and subject to making good any damage caused by the


                                       18
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     Purchaser or its representatives to the Property;

              5.1.9  use all reasonable endeavours to assist the Purchaser in
                     the assignment, transfer or grant to the Purchaser of all
                     statutory or regulatory licences necessary for the
                     Purchaser to carry on the Business;

              5.1.10 maintain the supply of all utilities required in connection
                     with the Business on terms no less favorable than those
                     which exist at the date of this agreement; and

              5.1.11 keep in force its existing insurance policies as disclosed
                     to the Purchaser in respect of the Business and the Assets.

6.     COMPLETION

       6.1    Completion of the sale and purchase of the Business and Assets
              shall take place on 15 October 1997 or (if later) three Business
              Days after the satisfaction or waiver of the last of the
              conditions in Clause 4 to be satisfied or waived. Completion shall
              take place at such location as is agreed by the Parties.

       6.2    At Completion the Vendor shall:-

              6.2.1  permit the Purchaser to assume the conduct of the Business
                     and possession of those of the Assets capable of passing by
                     delivery and the Purchaser will carry on the Business with
                     effect from the Completion Date;

              6.2.2  complete the sale or procure the completion of the sale to
                     the Purchaser of the Property in accordance with the terms
                     contained in or referred to in Schedule 3;


                                       19
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                  6.2.3    deliver to the Purchaser:-

                           6.2.3.1  the Disposition and any other items required
                                    to be delivered at Completion in terms of
                                    Schedule 3;

                           6.2.3.2  the Deeds and Documents;

                           6.2.3.3  the Information Technology Services
                                    Agreement;

                           6.2.3.4  the Supply Agreement;

                           6.2.3.5  the Secondment Letter;

                           6.2.3.6  duly executed assignments in agreed terms
                                    together with such other documents as the
                                    Purchaser may reasonably require to perfect
                                    its title to the Goodwill, the Intellectual
                                    Property, the Contracts and the Lease
                                    Contracts;

                           6.2.3.7  the Records;

                           6.2.3.8  all national insurance contributions and
                                    PAYE records duly completed and up to date
                                    in respect of the Employees;

                           6.2.3.9  all contracts of employment, statements of
                                    terms and conditions and all personnel
                                    records, files and details relating to the
                                    Employees;

                           6.2.3.10 the value added tax records referred to in
                                    Clause 17;


                                       20
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                           6.2.3.11 a letter from the Vendor (or the appropriate
                                    Vendor Group Company) transferring the IPC
                                    Authorizations to the Purchaser;

                           6.2.3.12 the Disclosure Letter;

                           6.2.3.13 the Employment Letter; and

                           6.2.3.14 the Glaxo Wellcome plc Letter.

       6.3    Upon fulfilment by the Vendor of its obligations under Clause 6.2
              the Purchaser shall:

              6.3.1  procure the payment by electronic funds transfer of the
                     sums due and payable under Clause 3 to National Westminster
                     Bank Plc sort code 50/00/OT account number 00462616 account
                     name Glaxo Group Limited; and

              6.3.2  deliver to the Vendor duly executed counterparts of the
                     documents referred to in Clause 6.2 as are required to be
                     executed by the Purchaser.

       6.4    The Purchaser shall not be obliged to complete the purchase of any
              of the Assets unless the purchase of all the Assets is completed
              in accordance with this agreement.

7.     REIMBURSEMENT OF COSTS

       7.1    The Purchaser undertakes that it will within 28 days of receipt by
              it of any relevant suppliers invoice, reimburse the Vendor the
              External Costs. The Purchaser shall have no liability under this
              clause unless it shall have given its written approval to any
              External Costs before any such costs are incurred by the Vendor.
              Such approval may be given by the Purchaser in respect of each
              specific item of cost or by approval of such costs within a
              specific project.


                                       21
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       7.2    The Vendor shall reimburse the Purchaser for any VAT in respect of
              such costs for which the Purchaser is liable and which is
              irrecoverable by the Purchaser.

       7.3    In the event that Completion has not taken place, for any reason
              whatsoever, by 15 November 1997 the Vendor shall repay forthwith
              to the Purchaser all sums paid by the Purchaser under Clause 7.1.

       7.4    The Vendor shall reimburse any costs (not exceeding the GWO budget
              and interest) incurred by the Purchaser in respect of the Business
              in the period from the date of this agreement to 31 December 1997
              insofar as such costs exceed the revenues of the Business to which
              the Purchaser is entitled during that period. The Vendor shall be
              entitled to require the Purchaser to provide such information as
              it reasonably requires to monitor and challenge any costs
              schedules produced by the Purchaser.

8.     COMPLETION STATEMENT

       8.1    On the Completion Date or as soon as practicable thereafter the
              Vendor shall carry out a physical count and a valuation of the
              Stock and Work in Progress as at the Completion Date. The
              Purchaser and its representatives shall be entitled to attend such
              count and valuation.

       8.2    The Stock and Work in Progress will (subject to the further
              provisions of this clause) be valued at the lower of cost and net
              realizable value using the same methods and bases (as nearly as
              may be practicable and insofar as they are consistent with good
              accounting and valuation practice and with all applicable SSAP's
              and FRS's) as those consistently adopted by the Vendor in the
              valuations of similar items for the purposes of the Accounts. No
              value will be attributed to any Stock or Work in Progress which is
              Defective, Obsolete or outside of its Shelf-Life. Provided 


                                       22
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Always that if the value of the Stock and Work in Progress (when
              valued in accordance with the provisions of this Clause 8.2)
              would, but for this proviso, exceed(pounds)1,000,000 it shall be
              certified as being and for all purposes relating to this agreement
              shall be (pounds)1,000,000.

       8.3    The Vendor will procure that a written certificate of the value of
              the Stock and Work in Progress calculated on the basis set out or
              referred to in Clause 8.2 ("the Completion Statement") is
              delivered to the Purchaser as soon as practicable following the
              Completion Date and in any event not later than 3 Business Days
              following such date. The Purchaser may within the period of 3
              Business Days following delivery of the Completion Statement by
              notice in writing to the Vendor dispute the value set out in the
              Completion Statement. If no such notice is received or if within
              the said period of 3 Business Days the value of the Stock and Work
              in Progress as set out in the Completion Statement or any amended
              amount is agreed between the Vendor and the Purchaser then the
              value as set out in the Completion Statement or (as the case may
              be) any amended amount shall be conclusive and binding upon the
              parties for the purposes hereof.

       8.4    If the Purchaser shall give notice of any dispute under Clause 8.3
              which is not resolved within the said period of 3 Business Days,
              such dispute shall be referred for determination in accordance
              with Clause 20.

9.     CONTRACTS

       9.1    With effect from the Completion Date the Purchaser shall take
              over, perform and complete the Contracts.

       9.2    Insofar as the benefit of any of the Contracts or Lease Contracts
              cannot effectively be transferred 


                                       23
<PAGE>   30

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              to the Purchaser (whether by assignment, novation or otherwise)
              without the consent of a third party and such consent has not been
              obtained at or prior to Completion:-

              9.2.1  the Vendor shall use all reasonable endeavours to obtain
                     such consent as soon as practicable;

              9.2.2  unless and until any such contract has been transferred to
                     the reasonable satisfaction of the Purchaser, the Purchaser
                     shall for its own benefit and to the extent that the
                     contract in question permits without constituting a breach
                     thereof, perform on behalf of the Vendor (but at the
                     Purchaser's expense) all the Vendor's obligations and the
                     Vendor will co-operate with the Purchaser (at the Vendor's
                     expense) in any reasonable arrangements designed to provide
                     for the Purchaser the benefits under any such contracts
                     including the enforcement of any and all rights of the
                     Vendor thereunder;

              9.2.3  in the event that any such contract cannot be fully and
                     effectually transferred to the Purchaser, the Parties shall
                     use their respective reasonable endeavours to procure that
                     the contract in question is terminated without liability to
                     the Parties. If termination without liability to the
                     Parties cannot be achieved the Purchaser shall have no
                     further obligation to the Vendor relating to the contract
                     in question and the Vendor shall indemnify the Purchaser
                     against any costs, claims, damages, liabilities, or
                     expenses arising from claims by any third party in relation
                     to the contract in question and the termination, assignment
                     or attempted 


                                       24
<PAGE>   31

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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


assignment of such contract without consent;

              9.2.4  if the Purchaser shall require, the Vendor shall enter into
                     novation agreements with the other parties to any of such
                     contracts to the intent that thenceforth the Purchaser
                     shall be in a direct contractual relationship with such
                     other parties.

10.    CREDITORS AND LIABILITIES

       10.1   The Vendor shall remain responsible for and shall promptly pay,
              discharge or satisfy all debts payable by the Vendor and other
              obligations and liabilities arising from or attributable to the
              carrying on of the Business prior to the Completion Date (save for
              any which are expressly assumed by the Purchaser under this
              agreement) including without limitation:-

              10.1.1 all liabilities to trade and other creditors including
                     banks and all liabilities in respect of Tax of the Vendor
                     or any company within the Vendor's Group;

              10.1.2 all liabilities and obligations accrued or falling to be
                     performed under the Contracts and the Lease Contracts up to
                     the Completion Date; and

              10.1.3 all claims made by third parties on or after the Completion
                     Date in respect of any goods or services supplied by the
                     Vendor or any company within the Vendor's Group or any act
                     or omission of the Vendor or any company within the
                     Vendor's Group prior to the Completion Date.

              The Vendor shall if so requested by the Purchaser promptly supply
              to the Purchaser written details 


                                       25
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              of all trade and other creditors of the Business subsisting at the
              Completion Date.

       10.2   The Vendor shall fully and effectively indemnify and keep
              indemnified the Purchaser against any liability, loss, damage,
              penalty, cost or expense (including reasonable legal and other
              professional fees) incurred in defending or resolving any actions
              or claims (civil or criminal) or in appealing against any
              judgment, notice or award and also including the cost of remedial
              work under or pursuant to or carried out to avoid the application
              of any Environmental Laws, which are suffered or incurred by the
              Purchaser and which arise out of the past use of the Property
              (including any activity, trade, business or operation carried out
              on the Property at anytime) whether arising before or after
              Completion and including, but without limitation, any liability,
              loss, damage, penalty, cost or expense arising directly or
              indirectly from the oil spillage which occurred on the Property in
              1992. Provided that the Vendor shall not be liable under this
              clause 10.2 if and to the extent that the matter giving rise to
              the claim would not have arisen but for the passing of or a change
              in, after the date of Completion a law, or regulation not actually
              prospectively in force at the date of this agreement. For the
              purposes of this clause Part IIA of the Environment Protection Act
              1990 as inserted by the Environment Act 1995 as it is brought into
              force and the first complete set of guidance and regulations
              adopted thereunder, and the amendment to Sections 161A to D of the
              Water Resource Act 1991 as inserted by the Environment Act 1995
              shall be deemed to be in force at the date of this agreement.

       10.3   The maximum liability of the Vendor under Clause 10.2 shall be
              ****.


                                       26
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       10.4   The Vendor is not liable under Clause 10.2 unless the Purchaser
              has given the Vendor written notice of the matter under Clause
              10.2 on or before the date which is **** after the Completion
              Date.

       10.5   If the Vendor pays to the Purchaser an amount under Clause 10.2
              and the Purchaser or any member of the Purchaser's Group
              subsequently recovers from a third party an amount which is
              directly referable to the matter giving rise to the claim under
              Clause 10.2 then:

              10.5.1 if the amount paid by the Vendor in respect of the claim
                     under Clause 10.2 is more than the sum recovered from the
                     third party, the Purchaser shall pay the Vendor the sum so
                     recovered; and

              10.5.2 if the amount paid by the Vendor in respect of the claim
                     under Clause 10.2 is less than or equal to the sum
                     recovered from the third party, the Purchaser shall pay the
                     Vendor an amount equal to the amount paid by the Vendor;

              For the purposes of this Clause 10.5 the "sum recovered" means an
              amount equal to the amount recovered from the third party less all
              reasonable costs and expenses incurred by the Purchaser or any
              member of the Purchaser's Group in recovering the amount from the
              third party.

       10.6   The Purchaser shall as soon as reasonably practicable give written
              notice to the Vendor of any matter which it becomes aware which is
              likely to give rise to a claim under Clause 10.2 and shall consult
              with the Vendor in respect to the matter and the Vendor shall be
              entitled to make such reasonable investigation into the matter as
              it thinks fit. If the Purchaser fails, for whatever reason, to
              comply with the terms of this Clause any such failure shall not
              affect the 


                                       27
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Purchaser's ability to make a claim under Clause 10.2.

       10.7   If and to the extent that the matter giving rise to the claim
              under Clause 10.2 concerns the reduction in value of the Property
              as a consequence of the Purchaser using and operating the Property
              for purposes other than pharmaceutical and intermediate
              manufacturing (including without limitation the use of the
              Property for residential uses or public recreation).

       10.8   Unless otherwise expressly provided, nothing in this agreement
              shall make the Purchaser liable in respect of anything done or
              omitted to be done by the Vendor or any company within the
              Vendor's Group prior to the Completion Date and the Vendor shall
              indemnify the Purchaser in full for and against any claims, costs,
              expenses or liabilities whatsoever and howsoever arising incurred
              or suffered by the Purchaser in connection with any of the debts,
              obligations and liabilities referred to in Clause 10.1 including
              costs incurred by the Purchaser in settling any claim in respect
              of such debts, obligations or liabilities. This indemnity shall
              extend without limitation to all legal expenses and other
              professional fees reasonably and properly incurred by the
              Purchaser.

       10.9   With effect from the Completion Date the Purchaser shall:-

              10.9.1 observe and perform or procure to be observed and performed
                     all the obligations of GWO under the Contracts and the
                     Lease Contracts except insofar as such obligations should
                     have been performed at or before the Completion Date and
                     except insofar as such obligations have not been fully and
                     effectively transferred to the Purchaser whether by
                     assignment, novation 


                                       28
<PAGE>   35

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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     or otherwise and it is not possible for the Purchaser to
                     perform or procure the performance thereof without
                     constituting a breach of the contract concerned;

              10.9.2 assume responsibility for payment for all goods delivered
                     or services received under the Contracts after the
                     Completion Date and which do not form part of the Stock or
                     Work in Progress whether the invoices for such goods or
                     services are received before or after the Completion Date;

              10.9.3 keep the Vendor and GWO fully and effectively indemnified
                     against any liability howsoever arising from the Contracts
                     or the Lease Contracts as a result of any act or omission
                     of the Purchaser after Completion.

11.    EMPLOYEES

       11.1   The Parties acknowledge that pursuant to the Regulations at the
              Completion Date the Purchaser it will become the employer of the
              Employees (but not the Excluded Employees).

       11.2   The Vendor shall indemnify the Purchaser in full for and against
              all claims, costs, expenses or liabilities whatsoever and
              howsoever arising incurred or suffered by the Purchaser including
              without limitation all legal expenses and other professional fees
              (together with any VAT thereon) arising out of or in respect of
              the employment or the termination of the employment of any of the
              Employees up to and including the Completion Date or arising out
              of the employment or the termination of the employment of the
              Excluded Employees or any other person in respect of the Business
              at any time.


                                       29
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       11.3   The Purchaser shall indemnify the Vendor and/or GWO in full for
              and against all claims, costs, expenses or liabilities whatsoever
              and howsoever arising incurred or suffered by the Vendor and/or
              GWO including without limitation any reasonable legal expenses and
              other professional fees (together with any VAT thereon) arising
              out of or in respect of the termination of the employment of the
              Employees after the Completion Date.

       11.4   The Vendor warrants that the Vendor and/or GWO (as applicable)
              have complied with Regulation 10 of the Regulations and will
              indemnify the Purchaser against any compensation for which the
              Purchaser may become liable as a result of any breach thereof by
              the Vendor. The Vendor shall have no liability to the Purchaser
              under this clause to the extent that any failure on its or GWO's
              part to comply with Regulation 10 is as a result of a failure on
              the part of the Purchaser to provide the Vendor with such
              information as the Vendor has requested regarding the Purchaser
              and its plans for the Business following Completion.

       11.5   All salaries and other emoluments including holiday pay, taxation
              and national insurance contributions and contributions to
              retirement benefit schemes relating to the Employees shall be
              borne by the Vendor up to and including the Completion Date and by
              the Purchaser with effect from the Completion Date and all
              necessary apportionments shall be made.

12.    PENSIONS

       The provisions set out in Schedule 4 shall apply to the Employees and
       govern their rights under the Disclosed Schemes.


                                       30
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


13.   APPORTIONMENT

       13.1   All rents, rates, gas, water, electricity, telephone charges and
              other outgoings relating to or payable in respect of the Business
              up to and including the Completion Date shall be borne and paid by
              the Vendor and as from the Completion Date shall be borne and paid
              by the Purchaser and shall be apportioned accordingly.

       13.2   All rents, royalties and other periodical payments receivable in
              respect of the Business up to the Completion Date shall belong and
              be payable to the Vendor and as from that time shall belong to and
              be payable to the Purchaser and shall be apportioned accordingly.

       13.3   The benefit of any prepayments, deposits or payments in advance
              made to the Vendor on or before the Completion Date in respect of
              goods and services to be supplied by the Purchaser after the
              Completion Date shall belong to the Purchaser and the benefit of
              any prepayments, deposits and payments in advance made by the
              Vendor in respect of goods ordered but not delivered and services
              contracted for but not rendered to the Vendor in connection with
              the Business on or before the Completion Date shall be reimbursed
              by the Purchaser to the Vendor.

       13.4   Any amount due from the Vendor or the Purchaser pursuant to
              Clauses 13.1, 13.2 or 13.3 shall be paid within 14 days of written
              request from the Purchaser or the Vendor (as the case may be) for
              the amount thereof together with supporting vouchers. If any
              dispute shall arise as to the amount of any apportionment
              hereunder such dispute shall be referred for final determination
              in accordance with Clause 20.

14.    WARRANTIES


                                       31
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       14.1   The Vendor warrants and represents to the Purchaser as at the date
              of this agreement in the terms of the Warranties.

       14.2   The Vendor shall further warrant and represent as at the
              Completion Date to the Purchaser in the terms of the Warranties as
              if they had been entered into afresh at Completion by reference to
              the facts and circumstances then existing.

       14.3   Each of the Warranties shall be construed as a separate and
              independent warranty and (save where expressly provided to the
              contrary) shall not be limited or restricted by reference to or
              inference from any other terms of this agreement or any other
              Warranty.

       14.4   The rights and remedies of the Purchaser in respect of any breach
              of any of the Warranties shall continue to subsist notwithstanding
              Completion.

       14.5   The Vendor hereby undertakes with the Purchaser that it will
              forthwith disclose in writing to the Purchaser any event or
              circumstance which may arise or become known to it after the date
              hereof and prior to Completion which is materially inconsistent
              with any of the Warranties or which has or is likely to have an
              adverse effect on the financial position or business prospects of
              the Business or which is otherwise material to be known by a
              purchaser for value of the Business.

       14.6   The Purchaser shall be given all such facilities as it (or its
              authorized representatives) may reasonably require to enable the
              Purchaser to be satisfied with regard to the accuracy of the
              Warranties provided that the Warranties shall not be deemed in any
              way modified or discharged by reason of any investigation made or
              to be made by or on behalf of the Purchaser or by reason of any
              information relating to the Business of which 


                                       32
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              the Purchaser has knowledge (actual implied or constructive)
              except such information as is fully and fairly disclosed in the
              Disclosure Letter.

       14.7   In the event of any breach or non-fulfilment of any of the
              Warranties resulting in:-

              14.7.1 the value of the Goodwill and/or any of the other Assets
                     being or becoming less than it would have been had the
                     relevant circumstances been as so warranted; or

              14.7.2 the Purchaser having incurred or incurring any liability
                     which it would not have incurred had the relevant
                     circumstances been as so warranted;

              then without prejudice to any other rights or remedies available
              to the Purchaser and without restricting its ability to claim
              damages on any other basis the Vendor agrees to pay to the
              Purchaser on demand an amount sufficient to make good the
              diminution in the value of the Goodwill and/or other Assets or an
              amount equal to the liability thereby incurred.

       14.8   The Vendor hereby agrees to indemnify the Purchaser in full for
              and against all costs (including reasonable legal costs) and
              expenses (together with any VAT thereon) incurred by the Purchaser
              either before or after the commencement of any action in
              connection with:-

              14.8.1 the settlement of any claim that any of the Warranties has
                     been breached or is untrue inaccurate or misleading;

              14.8.2 any legal proceedings arising out of or in connection with
                     any claim or breach of any of the Warranties in which
                     judgment is given in favour of the Purchaser; or


                                       33
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              14.8.3 the enforcement of any such settlement or judgment.

       14.9   The rights of the Purchaser under Clauses 14.7 and 14.8 shall be
              in addition and without prejudice to any other right or remedy
              available to it under this agreement or otherwise.

       14.10  Any amount paid by the Vendor to the Purchaser in respect of a
              breach of Warranty shall be treated primarily as a reduction in
              the Purchase Price.

       14.11  The Warranties shall be qualified by matters fully and fairly
              disclosed in the Disclosure Letter but shall otherwise be subject
              to no qualification whatsoever.

       14.12  The Purchaser acknowledges that no representations, or warranties
              express or implied are given by the Vendor in relation to the
              Business other than the Warranties themselves.

       14.13  The provisions of Schedule 6 shall have effect in respect of the
              matters to which this Clause 14 applies to limit the liability of
              the Vendor in respect of the Warranties.

15.    RIGHT TO RESCIND

       15.1   If the Vendor shall disclose any event or circumstance pursuant to
              sub-clause 14.5 or if there is a breach of any of the Warranties
              or a breach or non-fulfilment of any other term of this agreement
              by the Vendor, the Purchaser shall be entitled in addition and
              without prejudice to any other right or remedy available to it to
              rescind this agreement without any liability to any other party
              whereupon the Vendor shall indemnify the Purchaser in full for and
              against all claims, costs, expenses and liabilities incurred or
              suffered by the Purchaser (including but not limited to all legal
              and other professional fees 


                                       34
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              and expenses) in connection with the negotiation, preparation and
              rescission of this agreement as are incurred after the date of
              this agreement.

       15.2   The Purchaser shall not be entitled to exercise its right of
              rescission under Clause 15.1 unless the matter in question in the
              reasonable opinion of the Purchaser (having first discussed the
              matter with the Vendor) has had or is likely to result in a
              reduction in the value of the Assets of(pounds)1,000,000 or more.
              In arriving at its opinion as to whether such matter will have or
              has had such an effect the Purchaser shall act reasonably and in
              good faith and shall take into account the availability of
              insurance receipts in respect of such matter.

16.   POST COMPLETION OBLIGATIONS

       16.1   The Vendor undertakes to indemnify and keep indemnified the
              Purchaser against all liabilities, losses, obligations, costs,
              claims, damages, demands and expenses arising directly or
              indirectly out of the provision of a secure and adequate supply of
              at least 500,000 gallons a day of non saltwater water to the
              Property which is suitable for the purposes of the Business
              provided that the Vendor's liability under clause 16.1 shall be
              limited to 50% of such costs and the Vendor's liability shall be
              limited to such amount as is agreed pursuant to Clause ?.

       16.2   The Vendor undertakes to provide to the Purchaser in respect of
              the manufacturing site at Annan:

              16.2.1 within 10 Business Days of Completion audited financial
                     statements for the years ended 31 December 1994, 31
                     December 1995 and 31 December 1996;


                                       35
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              16.2.2 within 10 Business Days of Completion, copies of the
                     unaudited financial statements to Completion;

              16.2.3 within 28 days of Completion, copies of the audited balance
                     sheet and profit and loss accounts for the period from 31
                     December 1996 to Completion;

              16.2.4 by the later of 30 November 1997 and 28 days after
                     Completion unaudited quarterly accounts in respect of the
                     period from 1 January 1996 (being audited as at 31 December
                     1996) to Completion. In respect of any costs incurred by
                     the Vendor under this Clause 16.2.4 the Purchaser shall, if
                     required, pay the actual cost of any temporary assistance
                     up to a maximum of (pounds)5,000.

       16.3   The Vendor undertakes to the Purchaser to maintain adequate
              insurance in respect of Finished product at the Property both
              before and after Completion.

       16.4   The Vendor undertakes to obtain from the Vendor's Accountants
              authority to use any financial information available or required
              in respect of the Business (whether before or after Completion)
              under the requirements of the Securities and Exchange Commission
              and the Securities Act of 1933 and the Securities Exchange Act of
              1934 of the United States and to procure the co-operation of the
              Vendor's Accountants in respect of any public offering of Chirex
              Inc., including providing any customer comfort letters required by
              any underwriters of such offering and to procure access to any
              underlying records of the Vendor's Accountants or the Vendor's
              Group.

       16.5   The Parties undertake to one another that all Records delivered to
              the Purchaser at Completion shall be retained by the Purchaser and
              all the 


                                       36
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Retained Records shall be retained by the Vendor and each Party
              shall make available for inspection and reasonable use by the
              other Party all such books, records and other documents retained
              by it (or transferred to it as the case may be) relating to the
              Business as the other Party may request in finalizing its affairs
              in relation to the transfer of the Business and the Assets
              pursuant to this agreement and to give effect to this agreement.
              The rights and obligations contained in this clause shall expire
              on the sixth anniversary of Completion, save in respect of
              particular records (including but not limited to Control of
              Substances Hazardous to Health records) in respect of which there
              is a legal obligation to retain such Records for a longer period.
              The Purchaser undertakes to maintain and, on request, provide to
              the Vendor samples of Products (as are available on Completion)
              manufactured by the Vendor at the Property.

       16.6   The Purchaser shall procure at the Vendor's cost that for a period
              of 12 months after Completion those of the Employees whose
              assistance is reasonably required by the Vendor in connection with
              matters arising from its carrying out the Business prior to the
              Completion Date will be available at reasonable times to assist
              the Vendor provided that such assistance does not unduly interfere
              with their day-to-day function within the Business.

17.    VALUE ADDED TAX

       17.1   The purchase price of the Assets and the Business stated in this
              agreement is exclusive of VAT.

       17.2   The parties intend that the provisions of section 49 of the Value
              Added Tax Act 1994 and Article 5 of the Value Added Tax (Special
              Provisions) Order 1995 shall apply to the sale of the Business and
              the Assets and, accordingly, no VAT shall be 


                                       37
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              charged by the Vendor on them. The Vendor and the Purchaser shall
              each promptly following Completion inform their respective VAT
              offices of the sale and purchase under this agreement, complete
              all relevant forms for VAT purposes relating to such sale and
              purchase and take all reasonable steps to ensure that the sale of
              the Business and Assets is treated neither as a supply of goods
              nor a supply of services for the purposes of VAT but as the
              transfer of a going concern. In the event that it is at any time
              determined by HM Customs and Excise or, on appeal, by the tribunal
              or the court that section 49 of the Value Added Tax Act 1994 and
              Article 5 of the Value Added Tax (Special Provisions) Order 1995
              do not apply to the sale of the Business and Assets or any part of
              them, the Purchaser shall pay to the Vendor the amount of the VAT
              in question on the later of the business day before such amount is
              due to be paid by the Vendor to Customs & Excise and the day on
              which the Vendor delivers to the Purchaser a valid VAT invoice or
              invoices in respect thereof. Subject to the Vendor having complied
              with its obligations under this Clause 17 the Purchaser shall in
              addition pay any penalty and interest imposed by Customs and
              Excise in respect of late payment of such VAT.

       17.3   For the purposes of the said Article 5, the Vendor warrants that
              it carries on, and that it will immediately prior to Completion
              carry on, the Business.

       17.4   The Vendor shall, at Completion, deliver to the Purchaser all the
              records of the Business for VAT purposes which are required to be
              preserved by the Purchaser by section 49(1)(b) of the Value Added
              Tax Act 1994, and the Purchaser shall, for a period of not less
              than six years from the Completion Date, preserve the records so
              delivered and, upon reasonable notice, during normal 


                                       38
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              business hours make them available for inspection to the Vendor or
              its agent.

       17.5   The Purchaser confirms that it will be registered for VAT and will
              carry on the Business as a going concern immediately after
              Completion.

       17.6   The Purchaser confirms that it shall not apply for a reallocation
              of the Vendor's VAT registration number.

       17.7   The Vendor agrees that it will not at any time before Completion
              without the consent of the Purchaser exercise its right under VAT
              1994 Schedule 10 paragraph 2 to elect to tax the Property.

18.    CAPITAL GOODS SCHEME

       The Vendor will provide the Purchaser with all records and other
       information required by the Purchaser for the purposes of the Capital
       Goods Scheme in Part XV Value Added Tax Regulations 1995 (SI1995/2518)
       and any adjustments thereunder.

19.    FURTHER ASSURANCE

       19.1   Upon and at any time after Completion the Vendor shall at the
              request of the Purchaser and at the Vendor's cost do and execute
              or procure to be done and executed all such acts deeds documents
              and things as may be reasonably necessary to vest the title to the
              Business and Assets in the Purchaser and to give effect to this
              agreement.

       19.2   The Vendor will use all reasonable endeavours to ensure that all
              relevant authorisations, permissions, consents, licences or
              agreements are (where necessary) transferred to the Purchaser or,
              as the case may be, renewed. In particular, but without
              limitation, the Vendor shall assist the Purchaser in making
              application to or providing information to any relevant authority
              for the purpose of such transfer or renewal.


                                       39
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       19.3   Without prejudice to the terms of clause 19.1 the Vendor shall at
              the request of the Purchaser and at the Vendor's cost, execute or
              procure to be done and executed all such acts, documents and
              things as may be necessary or desirable in connection with:

              19.3.1 the loss of the original title deeds to the Property; and

              19.3.2 the application by the Purchaser to register the title to
                     the Property.

       19.4   The Vendor will at any time after Completion, at the Purchasers
              cost and at the request of the Purchaser execute such documents
              and give such assistance as is reasonable in ensuring that a
              secure and adequate supply of water is available to the Property
              for the purpose of the Business.

20.    DISPUTE RESOLUTION

       If there is a dispute between the Vendor and the Purchaser, pursuant to
       Clause 8.4 and/or 13.4, which the Vendor's Accountants and the
       Purchaser's Accountants cannot resolve, then the matter in dispute shall
       be referred to an independent firm of Chartered Accountants nominated
       jointly by them or if no such nomination is made within 14 days after the
       expiry of one party requiring nomination, nominated at the request of
       either of them by the President for the time being of the Institute of
       Chartered Accountants in England and Wales. The Accountants so nominated
       shall be entitled to ask for and inspect the working papers, records and
       documents of both Parties as they may reasonably consider necessary. In
       making their determination, the said Accountants shall act as experts and
       not as arbitrators, their decision shall (in the absence of manifest
       error) be final and binding on the Parties and their fees shall be borne
       and paid by the Vendor and the Purchaser in such proportions as the
       Accountants determine in the light of the 


                                       40
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       respective contentions of the Parties, and the Accountants'
       determination.

21.    SECONDMENT

       21.1   The Vendor undertakes to use its best endeavours to procure that
              at least 40 Employees are seconded during the period from
              Completion to 31 December 1998 to a Vendor Group Company on the
              terms set out in the Secondment Letter. The Vendor shall:

              21.1.1 make available, within the Vendor's Group, 40 suitable
                     positions for secondees of the Business;

              21.1.2 identify (after consultation with the Purchaser) 40
                     Employees suitable for secondment, and not required for the
                     Business during the period from Completion to 31 December
                     1998;

              21.1.3 make proposals, as soon as practicable, to such Employees
                     for their secondment; and

              21.1.4 use its reasonable endeavours to persuade such Employees to
                     accept its offer of secondment which may include increasing
                     relocation/secondment benefits.

       21.2   The Purchaser shall, following Completion use its reasonable
              endeavours to persuade such Employees to accept the offer of
              secondment made to them.


                                       41
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


22.    ANNOUNCEMENTS

       No announcement, communication or circular in connection with the subject
       matter of this agreement shall be made (prior to or after the Completion
       Date) by or on behalf of the Vendor or the Purchaser without the prior
       approval of the other (such approval not to be unreasonably withheld or
       delayed) save for:-

       22.1   announcements to Employees, customers, suppliers and agents of the
              Purchaser and the Business in such form as may be agreed between
              the Parties; and

       22.2   such announcements, documents, and other information as may be
              required by any recognized stock exchange or the Securities
              Exchange Commission and/or as required under the Securities Act of
              1933 and the Securities Exchange Act of 1934 or which would be
              customary for the Purchaser to make to investors, stockholders,
              analysts and within the Purchaser's Group.

23.    COSTS

       Subject to the provisions of Clause 15 each of the Parties shall bear and
       pay its own legal, accountancy and other fees and expenses incidental to
       the preparation and implementation of this agreement and all other
       documents in the agreed form referred to herein.

24.    SUCCESSORS AND ASSIGNMENT

       No Party may assign or transfer, or purport to assign or transfer, any of
       its rights or obligations under this agreement, save that the Purchaser
       shall be entitled to assign the benefit of the Warranties to any company
       in the Purchaser's Group.

25.    ENTIRE AGREEMENT


                                       42
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       25.1   This agreement (together with the documents referred to in it) and
              the Secrecy Agreement constitute the entire agreement between the
              parties in connection with its subject matter.

       25.2   Neither Party has relied on any representation or warranty except
              as expressly set out in this agreement.

26.    TIME OF THE ESSENCE

       As regards any time date or period mentioned in this agreement time shall
       be of the essence.

27.    NOTICES

       Any notice to be given pursuant to the terms of this agreement must be
       given in writing to the Party due to receive such notice at its
       registered office from time to time or at its address set out in this
       agreement or such other address as may have been notified for the purpose
       to the other Parties in accordance with this clause. Notice shall be
       delivered personally or sent by first class pre-paid recorded delivery or
       registered post (air mail if overseas) or by facsimile transmission and
       shall be deemed to be given in the case of personal delivery on delivery
       and in the case of posting (in the absence of evidence of earlier
       receipt) within 48 hours after posting (6 days if sent by air mail) and
       in the case of facsimile transmission on completion of the transmission.

28.    AGREEMENT CONTINUES IN FORCE

       This agreement shall remain in full force and effect so far as concerns
       any matter remaining to be performed at Completion and notwithstanding
       that Completion shall have taken place and in respect of any indemnities
       and undertakings on the part of the Vendor (including without prejudice
       to the generality those contained in Clauses 16 and 19, the Vendor shall
       at the Purchaser's request but at the Vendor's cost grant to the
       Purchaser, at intervals of not less than four years, 


                                       43
<PAGE>   50

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       written confirmation (in such form as the Purchaser may require) that
       this Clause remains fully binding on the Vendor notwithstanding the
       passage of time.

29.    SEVERABILITY

       The invalidity, illegality or unenforceability of any provision of this
       agreement shall not affect the continuation in force of the remainder of
       this agreement.

30.    WAIVER

       No waiver by the Purchaser of any breach or non-fulfilment by the Vendor
       of any provision of this agreement shall be deemed to be a waiver of any
       subsequent or other breach of that or any other provision hereof and no
       failure to exercise or delay in exercising any right or remedy under this
       agreement shall constitute a waiver thereof. No single or partial
       exercise of any right or remedy under this agreement shall preclude or
       restrict the further exercise of any such right or remedy. The rights and
       remedies of the Purchaser provided in this agreement are cumulative and
       not exclusive of any rights and remedies provided by law.

31.    VARIATIONS

       No variation of this agreement or any of the documents in the agreed
       terms shall be valid unless it is in writing and signed by or on behalf
       of each of the Parties.

32.    COUNTERPARTS

       This agreement may be executed in any number of counterparts each of
       which when executed by one or more of the Parties shall constitute an
       original but all of which shall constitute one and the same instrument.

33.    FUNDING

       The Vendor shall give due consideration prior to Completion to any
       comments made by funders of the 


                                       44
<PAGE>   51

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       Purchaser's Group in relation to the terms of this agreement.

34.    GOVERNING LAW

       34.1   Subject to the provisions of Clause 34.2 below, this agreement
              shall be governed by and construed in accordance with English Law
              and, subject to Clause 20, the Parties hereby submit for all
              purposes in connection with this agreement to the exclusive
              jurisdiction of the English Courts.

       34.2   The provisions of Schedule 3 and the Property Warranties are to be
              interpreted in accordance with Scots Law.

AS WITNESS the hands of the Parties or their duly authorized representatives the
day and year first above written

SIGNED by                             )
for and on behalf of GLAXO            )   /s/ Dr. G. Joseph Blaker
GROUP LIMITED in the presence of:-    )               
                                                      Dr. G. Joseph Blaker

Witness


Name


Address

SIGNED by                             )
for and on behalf of                  )   /s/ Michael A. Griffith
CHIREX (ANNAN) LIMITED                )
in the presence of:-                  )               Michael A. Griffith


Witness


Name


                                       45
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


Address


                                       46
<PAGE>   53

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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 1

                                     Part 1

                         Apportionment of Purchase Price

================================================
Asset                       Purchase Price
- ------------------------------------------------
Contracts                   (pounds)1
- ------------------------------------------------
Equipment                   (pounds)24,000,000
- ------------------------------------------------
Fixed Plant (Non            (pounds)1,000,000
Qualifying)
- ------------------------------------------------
Fixed Plant                 (pounds)5,000,000
(Qualifying)
- ------------------------------------------------
Goodwill                    (pounds)7,000,000
- ------------------------------------------------
Intellectual                (pounds)1
Property
- ------------------------------------------------
Property                    (pounds)2,999,998
- ------------------------------------------------
Stock/Work in               as determined under
Progress                    Clause 8
================================================


                                     Part 2

                                 Excluded Assets


1.     Cash;

2.     All Finished Products;

3.     The rights to use the name Glaxo, Wellcome, Glaxo Wellcome or their
       respective logos;


                                       47
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


4.     Any amounts recoverable by members of the Vendor's Group in respect of
       Tax and VAT allowances and repayments attributable to matters or events
       occurring on or before Completion;

5.     The benefit of any insurance claims arising prior to Completion in
       relation to the Business save where such claims relate to Assets to be
       acquired by the Purchaser under this agreement; and

6.     All Book Debts.

7.     All intellectual property in respect of the products manufactured at any
       time at the Property by any member of the Vendor's Group.


                                       48
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 2

                                  The Property

(In the First Place) (Primo) ALL and WHOLE the Farm of Waterfoot, Annan, part of
the Estate of Newbie in the County of Dumfries extending to one hundred and
sixty two acres and one hundred and forty three decimal or one thousandth parts
of an acre or thereby being the subjects described in and disponed by and
delineated and shown within red lines on the plan annexed and executed as
relative to the Disposition by Newbie Estates (in voluntary liquidation) and
David Simpson Carson, the Liquidator thereof, in favor of Newbie Salmon
Fisheries Limited dated Seventh and recorded in the Division of the General
Register of Sasines for the County of Dumfries on Nineteenth both days of
January Nineteen hundred and Fifty five: Together with the foreshore of the
Solway Firth and of the River Annan ex adverso the said subjects: BUT EXCEPTING
ALWAYS from the said subjects the whole of the salmon and other fishing rights
ex adverso the same; (Secundo) ALL and WHOLE that lot or piece of ground
extending to one thousand one hundred and twenty five square yards or thereby
being the south-west corner of the field marked number 847 on the Ordnance
Survey map of the Parish of Annan in the County of Dumfries being the subjects
described in and disposed by and delineated and coloured red on the Plan annexed
and subscribed as relative to the Feu Charter by William Dalziel MacKenzie in
favor of himself and Patrick Alexander Pasley Dirom and another, as Trustees for
behoof of the District Board of the River Annan, dated Third and recorded in the
said Division of the General Register of Sasines on Seventeenth both days of
October Nineteen hundred and Ninety three; (Tertio) ALL and WHOLE that area of
ground in the County of Dumfries on which was erected the subjects known as
Newbie Villa being the subjects described in and disponed by and shown outlined
in red on the excerpt of the Ordnance Survey map annexed and executed as
relative to the Disposition by Newbie Salmon Fisheries (Property) Limited in
favor of Glaxo Properties Limited dated Twenty seventh September and recorded in
the said Division of the General Register of Sasines on Sixteenth December both
months in 


                                       49
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


Nineteen hundred and Seventy six; and (Quarto) ALL and WHOLE that area of ground
in the County of Dumfries being the subjects described in and (in the Second
Place) disponed by and shown coloured blue between the points "E" and "F" on the
plan annexed and executed as relative to the Deed of Servitude (containing
Disposition and Assignation) by the Rt. Hon. John Frederick, Baron Gretton,
David Stewart Bowser and John Gerard Freeman, as Trustees therein mentioned, in
favor of Glaxo Properties Limited dated Third, Fourteenth and Nineteenth July
Nineteen hundred and Seventy eight and recorded in the said Division of the
General Register of Sasines on Eighth April Nineteen hundred and Eighty; (In the
Second Place) ALL and WHOLE that irregular shaped area or plot of ground in the
County of Dumfries extending to two hundred and twenty square metres or thereby
lying to the south-east of Three Trees Road, Newbie, Annan being the area or
plot of ground more particularly described in, disponed (In the First Place) by
and shown delineated in red on Plan A annexed and executed as relative to
Disposition by Northern Engineering Industries Limited in favor of Glaxo
Operations UK Limited dated Eighteenth April and recorded in the said Division
of the General Register of Sasines on Eleventh June both months in Nineteen
hundred and Eighty TOGETHER WITH (One) the whole buildings and other erections
thereon; (Two) the whole parts, privileges, rights and pertinents thereof or
otherwise offering thereto including without prejudice to the foregoing
generality the servitude and other rights granted in favor of the said subjects
or any part thereof in (a) Deed of Servitude granted by Joseph Robinson in favor
of Glaxo Properties Limited dated Seventh and recorded in the said Division of
the General Register of Sasines on Twenty eighth both days of March Nineteen
hundred and Seventy eight; (b) Deed of Servitude granted by Neil Graham in favor
of Glaxo Properties Limited dated Thirty first March and recorded in the said
Division of the General Register of Sasines on Seventh April both months in
Nineteen hundred and Seventy eight; (c) the said Deed of Servitude (containing
Disposition and Assignation) granted by the Rt. Hon. John Frederick, Baron
Gretton, David Stewart Bowser and John Gerard Freeman, as Trustees therein
mentioned, in favor of Glaxo Properties Limited; (d) Grant of Servitude granted
by the Secretary of State for Defence in favor of Glaxochem 


                                       50
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


Limited dated Eighteenth September Nineteen hundred and Eighty four and recorded
in the said Division of the General Register of Sasines on Thirtieth January
Nineteen hundred and Eighty five; and (e) Minute of Agreement and Deed of
Excambion between Royal Ordnance plc, the Trustees of Edward William Brook and
Glaxochem Limited dated Twenty fifth and Thirtieth August and Twenty eighth
October both months in Nineteen hundred and Ninety three and Twenty first March
Nineteen hundred and Ninety four and recorded in the said Division of the
General Register of Sasines for publication and also as in the Books of the
Lords of Council and Session for preservation on Third June Nineteen hundred and
Ninety four; (In the Third Place) ALL and WHOLE (FIRST) that rectangular piece
of ground lying on the right bank of the River Annan and on the north-east side
of Milnby Quarry together with the access road leading thereto comprising part
of area number 0900 in the County of Dumfries on the 1:2500 inch Ordnance Survey
map NY1867 and being the subjects shown delineated black and coloured pink on
the plan annexed and executed as relative to the said Minute of Agreement and
Deed of Excambion among Royal Ordnance plc, the Trustees of Edward William Brook
and Glaxochem Limited dated Twenty fifth and Thirtieth August and Twenty eighth
October both months in Nineteen hundred and Twenty three and Twenty first March
nineteen hundred and ninety four and recorded in the said Division of the
General Register of Sasines on Third June Nineteen hundred and Ninety four and
(SECOND) that oblong area of ground comprising compartment 4404 in the said
County situated on the north-eastern corner of area number 0002 on the 1:2500
inch Ordnance Survey map NY1867 and being the subjects shown delineated black
and coloured pink on the said plan annexed and signed as relative to the said
Minute of Agreement and Deed of Excambion dated and recorded as aforesaid
TOGETHER WITH (One) the whole buildings and erections on the said subjects
including, without prejudice to the foregoing generality, the pump house erected
on the subjects (FIRST) described and the pumping station erected on the
subjects (SECOND) described; (Two) the whole parts, privileges, rights and
pertinents offering to the subjects including, without prejudice to the
foregoing generality, the heritable and irredeemable servitude and other rights
specified in the 


                                       51
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


Disposition by Newbie Estates in favor of the Minister of Supply in trust as
therein mentioned dated Fifth May Nineteen hundred and Forty three and recorded
in the said Division of the General Register of Sasines on Twenty sixth December
Nineteen hundred and Forty four; (Three) entry to the subjects by existing roads
and ways used for that purpose.

Declaring that the various servitude rights constituted in favor of the subjects
above described (In the First Place) by the said five deeds, and any other
servitudes in favor of such subjects which may be constituted by possession,
shall in this agreement and the Schedules thereto be referred to as "the
Servitudes", and the whole heritable subjects above described, under exception
of the Servitudes, shall in the this agreement and the Schedules thereto be
referred to as "the Subjects", declaring that the Subjects shall be deemed to
comprise the whole of the Property under exception only of the Servitudes.


                                       52
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 3

                  Terms and Conditions of Sale of the Property

1.     EXHIBITION OF TITLE/DELIVERY OF DEEDS

       1.1    The Vendor warrants that no application has been made for
              registration of title to any part of the Property in the Land
              Register.

       1.2    On the Completion Date the Vendor shall deliver to the Purchaser a
              subscribed Disposition in favor of the Purchaser or its nominees,
              which shall if the Purchaser requires have attached to it a
              taxative plan of the Property acceptable to the Purchaser and
              complying with the specific plan requirements of the Keeper as
              published from time to time and a subscribed Deed of Servitude in
              favor of the Purchaser or its nominees in respect of the Water
              Supply in terms of the draft annexed hereto (Annex 3) and shall
              exhibit or deliver a valid and marketable title to the Property
              (including without prejudice to the generality both the Subjects
              and the Servitudes) together with:

              1.2.1  clear Searches in the Register of Sasines for 40 years (or
                     if longer from the date of the prescriptive writ) and in
                     the Register of Inhibitions and Adjudications for the
                     prescriptive period; and

              1.2.2  a Form P16 Report confirming that the Keeper can identify
                     the Property on the relevant Ordnance Survey Sheet, a Form
                     10 Report brought down to a date as near as practicable to
                     the Completion Date disclosing no entries adverse to the
                     Vendor's interest, and such documents or evidence,
                     including a plan or plans, as the Keeper may require to
                     enable the Keeper to issue a Land Certificate or Land
                     Certificates in name of the 


                                       53
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     Purchaser or its nominees (as the case may be) as the
                     registered proprietor of the Property (including without
                     prejudice to the generality the Servitudes) and containing
                     no exclusion of indemnity in terms of Section 12(2) of the
                     1979 Act.

       1.3    There will also be delivered by the Vendor to the Purchaser on the
              Completion Date:

              1.3.1  Searches/Reports in the Register of Charges/Mortgage
                     Register and Company File against any company (including
                     the Vendor) having an interest in the Property within the
                     period of 10 years prior to the Completion Date; such
                     Searches/Reports, continued to a date 22 days after the
                     date such company divested itself of its interest in the
                     Property, shall be clear of entries prejudicial to the
                     ability of the Vendor to grant a valid unencumbered title
                     to the Property in name of the Purchaser or its nominees;

              1.3.2  in relation to the document in terms of which any company
                     referred to in paragraph 1.3.1 divested itself of its
                     interest in the Property, evidence that at the time of
                     signature any person bearing to sign that document as a
                     Director or Secretary of such company was such a Director
                     or Secretary, and that any person signing that document on
                     behalf of such company bearing to have been authorized to
                     do so was authorized to do so;


                                       54
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              1.3.3  in the case of any body corporate (including the granter of
                     said Disposition) having an interest in the Property within
                     the period of 10 years prior to the Completion Date,
                     evidence that, at the time of signature of any document in
                     terms of which such body corporate divested itself of its
                     interest in the Property, all persons signing that document
                     on behalf of such body corporate were authorized to do so
                     whether in their capacity as office holders of such body
                     corporate or otherwise, except where authority so to sign
                     is presumed under the Requirements of Writing (Scotland)
                     Act 1995;

              1.3.4  a subscribed Assignation of the Water Extraction Consents
                     in the form annexed hereto (Annex 2) completed as
                     appropriate;

              1.3.5  Dundas & Wilson's Letter of Obligation in the form annexed
                     hereto (Annex 4) completed as appropriate and duly
                     subscribed;

              1.3.6  any other items required to be delivered on the Completion
                     Date in terms of any other provision of this Schedule 3.

2.     VENDOR'S POST-SETTLEMENT OBLIGATIONS REGARDING TITLE

       2.1    The Vendor shall procure that the Land Certificate(s) to be issued
              to the Purchaser or its nominees (as the case may be) in respect
              of the whole of the Property will disclose no entry, deed or
              diligence prejudicial to the Purchaser's or its nominees' interest
              other than such as are created by or against the Purchaser or its
              nominees or have been disclosed to and accepted by the Purchaser
              in terms of this agreement.


                                       55
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       2.2    The Vendor shall exhibit or deliver to the Purchaser within twenty
              days of written demand such documentation, evidence and others
              (including plans) as may be requisitioned by the Keeper in
              connection with the registration of the interest of the Purchaser
              or its nominees (as the case may be) in respect of the whole or
              any part of the Property in the Land Register.

3.     THE GRAZING LEASE

       It shall be an essential condition of this agreement that within 21 days
       of the execution thereof the Vendor shall deliver to the Purchaser a
       subscribed statement and undertaking issued by Messrs J.M. & J. Goldie,
       Newbie Mains, Annan as tenant under the Grazing Lease, and each of the
       individual Partners thereof, confirming that their sole entitlement to
       occupy the subjects of the Grazing Lease is in terms of the Grazing
       Lease, and without prejudice to the generality no agricultural tenancy
       has been created in respect of the subjects of the Grazing Lease, either
       by the Grazing Lease or otherwise, and undertaking to remove from the
       subjects of the Grazing Lease on or before 30 November 1997.

4.     APPORTIONMENTS ETC

       The sums due to the Vendor under the Grazing Lease and the Hoddam
       Agreement shall be apportioned between the Vendor and the Purchaser as at
       the Completion Date, and the apportionment in respect of the Hoddam
       Agreement shall be calculated on the basis of a meter reading taken at
       close of business on the day preceding the Completion Date. The Vendor
       shall indemnify the Purchaser fully against any and all liability which
       the Purchaser may incur in relation to any breach of the terms of the
       Grazing Lease or the Hoddam Agreement by the Vendor prior to the
       Completion Date.


                                       56
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


5.     ASSIGNATION OF RIGHTS

       On or prior to the Completion Date the Vendor shall deliver to the
       Purchaser a subscribed assignation in favor of the Purchaser or its
       nominees assigning to the Purchaser all rights which the Vendor shall
       have in respect of the design, construction, manufacture, assembly or
       installation of any buildings, structures, civil engineering or other
       similar works, plant and equipment, machinery and fixtures and fittings
       on or in the Property, along with certified true copies of all
       documentation (or alternatively a warranted statement confirming the
       whole terms and conditions of the contract) on the basis of which any
       such buildings or others were constructed or otherwise as aforesaid,
       together with evidence that any requisite consent to such assignation has
       been granted, and that in the form annexed hereto (Annex 5) (completed as
       appropriate).

6.     THE ACCESS AGREEMENT

       Following Completion the Vendor shall notify the relevant authority of
       the disposal of its interest in the Property as required by Clause FIRST
       of the Access Agreement.


                                       57
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 4

                                    Pensions


                            Part 1: Disclosed Schemes

                        The Glaxo Wellcome Pension Scheme
             The Glaxo Wellcome Contracted Out Money Purchase Scheme

                           Part 2: Transfer Provisions

1      Definitions

       1.1    In this Part of this Schedule the following expressions shall have
              the following meanings:

              "Actuary"                          a Fellow of the Institute of
                                                 Actuaries or a Fellow of the
                                                 Faculty of Actuaries in
                                                 Scotland or a firm employing
                                                 such persons;

              "Actuary's Letter"                 the letter from the Vendor's
                                                 Actuary to the Purchaser's
                                                 Actuary dated 10 September 1997
                                                 a copy of which is annexed to
                                                 this Schedule;

              "Adjusted Transfer          (a)    in relation to transfers
                 Requirement"                    Requirement" from the Vendor's
                                                 Scheme in respect of FS
                                                 Benefits, the Pension
                                                 Liabilities multiplied by the
                                                 Timing Adjustment in respect of
                                                 the period from and including
                                                 the Completion Date to but


                                       58
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                                 excluding the Due Date; and

                                          (b)    in relation to transfers from
                                                 the Vendor's Scheme in respect
                                                 of MP Benefits an amount
                                                 representing at the Due Date
                                                 the aggregate of the member's
                                                 accounts to which the
                                                 Consenting Members acquire a
                                                 right on ceasing to be in
                                                 pensionable service under the
                                                 Vendor's Scheme at the
                                                 Completion Date;

              "Consenting Members"               means those Transferring
                                                 Members who have submitted
                                                 Transfer Forms to the Vendor's
                                                 Scheme not later than 13 weeks
                                                 after the later of

                                          (a)    being advised by the trustees
                                                 of the Purchasers Scheme of the
                                                 benefits to be provided for
                                                 them in respect of any transfer
                                                 made in respect of them
                                                 pursuant to this Schedule; and

                                          (b)    the Completion Date

                                                 and who do not withdraw such
                                                 consent prior to payment of the
                                                 Transfer Amount;

              "Approval"                         approval by the Board of Inland
                                                 Revenue as an 


                                       59
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                                 exempt approved scheme for the
                                                 purposes of Chapter I of Part
                                                 XIV of the Taxes Act;

              "Due Date"                         the first working day one week
                                                 after the satisfaction of the
                                                 last to be satisfied of the
                                                 Transfer Conditions;

              "FS Benefits"                      means the benefits to which a
                                                 Consenting Member is entitled
                                                 or prospectively and
                                                 contingently entitled and which
                                                 are determined on a final
                                                 salary basis under the Vendor's
                                                 Scheme;

              "Independent Actuary"              an Actuary who is nominated by
                                                 the Vendor and the Purchaser
                                                 jointly or, if they cannot
                                                 agree, by the President of the
                                                 Institute of Actuaries on
                                                 application by either the
                                                 Vendor or the Purchaser;

              "MP Benefits"                      means the Benefits
                                                 (disregarding any additional
                                                 voluntary contributions and
                                                 benefits derived from them) to
                                                 which a Consenting Member is
                                                 entitled or prospectively and
                                                 contingently entitled and which
                                                 are determined on a money
                                                 purchase basis under the
                                                 Vendor's Scheme;


                                       60
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              "Pensionable Salary"               such remuneration of the
                                                 Relevant Employees as in each
                                                 case is pensionable in
                                                 accordance with the governing
                                                 documentation of the Vendor's
                                                 Scheme;

              "Pension Liabilities"              as defined in the Actuary's
                                                 Letter;

              "Pensionable Service"              such service of the Relevant
                                                 Employees as in each case is
                                                 used for the purpose of
                                                 calculating pension benefits
                                                 under the Vendor's Scheme;

              "Purchaser's Actuary"              the Actuary appointed by the
                                                 Purchaser from time to time for
                                                 the purposes of this Schedule;

              "Purchaser's Scheme"               the ChiRex Pension Scheme
                                                 established by an interim trust
                                                 deed dated 5 February 1996 (or
                                                 where the context so requires,
                                                 the trustees for the time being
                                                 of that scheme);

              "Relevant Employees"               those Employees who at
                                                 Completion are active members
                                                 of the Vendor's Scheme;

              "Timing Adjustment"                as defined in the Actuary's
                                                 Letter;

              "Transfer Amount"                  the amount (if any) which the
                                                 Vendor's Scheme pays to the
                                                 Purchaser's Scheme 


                                       61
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                                 in respect of the Consenting
                                                 Members;

              "Transfer Conditions"              all of the following:

                                          (1)    the Board of Inland Revenue has
                                                 given its written approval to
                                                 the transfer of assets from the
                                                 Vendor's Scheme to the
                                                 Purchaser's Scheme in respect
                                                 of the Transferring Members and
                                                 that approval still subsists;

                                          (2)    the Vendor's Scheme has
                                                 received the Transfer Forms
                                                 from Consenting Members; and

                                          (3)    the amount of the Pension
                                                 Liabilities has become final
                                                 and binding whether by
                                                 agreement under paragraph 4 or
                                                 following determination of any
                                                 dispute under paragraph 7;

              "Transfer Form"                    means the document (prepared in
                                                 such form as the Vendor and the
                                                 Purchaser shall agree: such
                                                 agreement not to be
                                                 unreasonably withheld or
                                                 delayed) which shall include a
                                                 discharge in favor of the
                                                 Vendor's Scheme which each
                                                 Consenting Member signs
                                                 confirming his request 


                                       62
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                                 for or consent to a payment or
                                                 transfer being made from the
                                                 Vendor's Scheme to the
                                                 Purchaser's Scheme for and in
                                                 respect of him and under which
                                                 he exercises his right in
                                                 relation to his cash equivalent
                                                 in accordance with the
                                                 provisions of Part IV of
                                                 Chapter IV of the 1993 Act so
                                                 as to acquire transfer credits
                                                 or other rights under the
                                                 Purchaser's Scheme;

              "Transferring Members"             those Relevant Employees who
                                                 become members of the
                                                 Purchaser's Scheme with effect
                                                 from Completion Date pursuant
                                                 to the offer of membership
                                                 referred to in paragraph 2
                                                 below and whose names shall be
                                                 provided to the Vendor by the
                                                 Purchaser within 28 days of the
                                                 Completion Date;

              "Vendor's Actuary"                 the Actuary appointed by the
                                                 Vendor from time to time for
                                                 the purposes of this Schedule;

              "Vendor's Scheme"                  the Glaxo Wellcome Pension
                                                 Scheme (or, where the context
                                                 so requires, the trustees of
                                                 that scheme);

              "1993 Act"                         the Pension Schemes Act 1993;


                                       63
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              "1995 Act"                         the Pensions Act 1995


                                       64
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


2      The Purchaser's Scheme

       The Purchaser undertakes to the Vendor that:-

       2.1    the Purchaser shall procure that not later than 14 days after
              Completion Date all Relevant Employees who have not reached their
              retirement date or otherwise ceased to be active members under the
              Vendor's Scheme shall be invited in writing to become members of
              the Purchaser's Scheme with effect from the Completion Date. The
              invitations must be consistent with this Schedule and in this
              respect they shall be subject to the prior approval of the Vendor
              (which shall not be unreasonably withheld or delayed). For the
              avoidance of doubt any Relevant Employee who dies between the
              Completion Date and the date on which the Relevant Employee either
              becomes a member of the Purchaser's Scheme or is deemed under the
              terms of the invitation to have rejected the invitation shall be
              provided with lump sum death in service benefits and survivor's
              benefits as if he or she had been a member of the Purchaser's
              Scheme with effect from the Completion Date;

       2.2    the Purchaser's Scheme shall at the Completion Date either have
              received Approval or be capable of receiving Approval and be a
              scheme to which the Vendor's Scheme can make a transfer payment
              without prejudicing the Approval of the Vendor's Scheme;

       2.3    the Purchaser undertakes that in respect of the Transferring
              Members and their service with the Purchaser from the Completion
              Date benefits will be provided (subject to the terms of the
              Purchaser's Scheme relating to amendment and discontinuance) on
              the same basis as they are provided for other employees of the
              Purchaser under that scheme.


                                       65
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


3      Calculation of the Transfer Requirement

       3.1    Within a period of 2 months following the Completion Date the
              Vendor shall procure that the Vendor's Actuary receives all
              material information under the Vendor's control which is necessary
              to calculate the Pension Liabilities and the Purchaser shall
              procure that the Vendor's Actuary receives all material
              information under the Purchaser's control required to calculate
              the Pension Liabilities;

       3.2    Within a period of 2 months following the receipt by the Vendor's
              Actuary of the complete, true and accurate information required to
              calculate the Pension Liabilities, the Vendor shall procure that
              the Vendor's Actuary calculates the Pension Liabilities and
              submits his results in writing to the Purchaser's Actuary for
              verification by the Purchaser's Actuary together with such
              information as the Purchaser's Actuary may reasonably require for
              the purpose of verifying the Vendor's Actuary's calculations;

       3.3    At the date which is 2 months after the date of receipt by the
              Purchaser's Actuary of details of the calculations described in
              3.2 above the Purchaser's Actuary shall be deemed to have agreed
              to those calculations and to the amount of the Pension Liabilities
              so calculated unless he shall within that time have notified the
              Vendor's Actuary in writing to the contrary;

       3.4    If the Vendor's Actuary and the Purchaser's Actuary cannot agree
              the amount of the Pensions Liabilities within a period of 3 months
              after the date of receipt by the Purchaser's Actuary of details of
              the calculations described in 3.3 above (or such earlier or later
              date as the Vendor and the Purchaser may agree), then either the
              Vendor or the Purchaser may require by notice in writing to the
              other the amount of the Pension Liabilities 


                                       66
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              to be determined by an Independent Actuary in accordance with
              paragraph 7 below.

4      Payment of the Transfer Requirement and Provision of Benefits

       4.1    The Vendor shall use its reasonable endeavours to procure that the
              Vendor's Scheme shall pay the Adjusted Transfer Requirement to the
              Purchaser's Scheme on or before the Due Date.

       4.2    The Adjusted Transfer Requirement shall be satisfied by the
              transfer of such assets (which may include cash in whole or part)
              as shall be agreed by the Vendor's Scheme and the Purchaser's
              Scheme and in default of agreement shall be in cash.

       4.3    Subject to receipt of the Adjusted Transfer Requirement on the Due
              Date by the Purchaser's Scheme and/or of any payment which falls
              due under paragraph 5 below, the Purchaser will procure that
              benefits are provided for and in respect of the Consenting Members
              under the Purchaser's Scheme in respect of their service prior to
              the Completion Date:

              4.3.1  in relation to the FS Benefits of each Consenting Member,
                     which are of equivalent value overall, in the reasonable
                     opinion of Purchaser's Actuary and on an actuarial basis
                     consistent with that set out in the Actuary's Letter, to
                     those which would have been provided for and in respect of
                     them under the Vendor's Scheme (as in force at the
                     Completion Date) on retirement, death or withdrawal if the
                     Consenting Member had continued in Pensionable Service
                     under the Vendor's Scheme calculated by reference to
                     Pensionable Salary at retirement, death 


                                       67
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     or withdrawal but related only to service prior to the
                     Completion Date; and

              4.3.2  in relation to the MP Benefits of each Consenting Member,
                     which are of equivalent value, in the reasonable opinion of
                     Purchaser's Actuary, and on an actuarial basis consistent
                     with that set out in the Actuary's Letter, to the amount
                     transferred in respect of each of them (which Vendor's
                     Actuary shall identify to Purchaser's Actuary) pursuant to
                     para (b) of the definition of Adjusted Transfer
                     Requirement.

       4.4    The Purchaser's Actuary shall certify to the Vendor's Actuary that
              the benefits to be provided by the Purchaser's Scheme comply with
              paragraph 4.3 above.

5      Adjustments to the Transfer Requirement

       5.1    If at the Due Date the Transfer Amount is less than the Adjusted
              Transfer Requirement the Vendor shall (subject to paragraph 5.2
              below) pay, as an adjustment to the consideration, to the
              Purchaser the amount equal to the difference between the Transfer
              Amount and the Adjusted Transfer Requirement less the percentage
              rate of Corporation Tax applying generally on the Due Date
              multiplied by the Timing Adjustment in respect of the period from
              the Due Date to the actual date of payment (such amount being
              known as "the Shortfall") within a period of 5 working days after
              the Due Date.

       5.2    No payment shall be due from the Vendor pursuant to paragraph 5.1:

              5.2.1  if the reason for the Transfer Amount (or part of it) not
                     having been


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     transferred to the Purchaser's Scheme at the Due Date is
                     the failure of the Purchaser's Scheme, for whatever reason,
                     to accept the whole, or any part of the Transfer Amount, or
                     if the reason is any other reason outside the control of
                     the Vendor's Scheme but, if no payment is due from the
                     Vendor because of any such other reason outside the control
                     of the Vendor's Scheme, payment will become due (in
                     accordance with paragraph 5.1) if, and when, such reason
                     ceases to exist;

              5.2.2  unless the Purchaser undertakes in writing to the Vendor to
                     pay any amount received pursuant to 5.1 above forthwith to
                     the Purchaser's Scheme.

6      Additional Voluntary Contributions

       6.1    Any additional voluntary contributions paid by Consenting Members
              to Vendor's Scheme and all benefits derived therefrom on a money
              purchase basis shall be disregarded for the purposes of this part
              of this Schedule other than this paragraph 6. The Vendor shall use
              its reasonable endeavours to procure that on the Due Date the
              Vendor's Scheme transfers or procures the transfer to the
              Purchaser's Scheme of the amount of any such additional voluntary
              contributions paid by the Consenting Members to the Vendor's
              Scheme together with accumulated interest or bonuses thereon in
              such form (which may include cash in whole or part) as shall be
              agreed by the Vendor's Scheme and the Purchaser's Scheme and in
              default of agreement shall be in cash;

       6.2    The Purchaser shall procure that the Purchaser's Scheme applies
              the amount of such transfer as is described in 6.1 above in the
              provision of additional benefits on a money purchase basis under
              the Purchaser's Scheme for and in respect of 


                                       69
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              each relevant individual Consenting Member who has paid such
              additional voluntary contributions.

7      Independent Actuary

       Any dispute between Vendor and Purchaser or between Vendor's Actuary and
       Purchaser's Actuary about any matters referred to in this Schedule shall,
       in the absence of agreement, be referred to an Independent Actuary. The
       Independent Actuary will act as an expert and not as an arbitrator. His
       decision will (except in the case of manifest error) be final and
       binding. His expenses will be borne equally by Vendor and Purchaser or as
       he may otherwise direct.

8      Indemnity

       The Purchaser shall indemnify and keep indemnified the Vendor on an
       after-tax basis against all actions, proceedings, reasonable costs,
       claims, damages and reasonable expenses arising from, or in connection
       with, any claim brought against the Vendor by, or on behalf of, a
       Transferring Member on grounds that the benefits provided under the
       Purchaser's Scheme in respect of service after the Completion Date are
       inferior to those provided under the Vendor's Scheme immediately prior to
       the Completion Date.

                               Part 3: Warranties

1      Except under the Disclosed Schemes no agreement, arrangement, custom or
       practice (whether ex-gratia or otherwise) exists whereby the Vendor is
       under any obligation to provide or pay towards the provision of any
       relevant benefits (as defined in Section 612(1) Taxes Act with the
       omission of the exception to that definition) for any Employee or for any
       dependent of any Employee.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


2      In relation to each Disclosed Scheme full details of the Disclosed Scheme
       have been given to the Purchaser including:-

       2.1    true and complete copies of the trust deeds rules and other
              documents containing the provisions currently governing the
              Disclosed Scheme;

       2.2    copies of the booklet issued to employees who are or may become
              members of the Disclosed Scheme and of all announcements or other
              employee literature issued to such employees which detail changes
              to the provisions of the Disclosed Scheme which are not
              incorporated in the Disclosed Scheme's formal governing documents;

       2.3    in relation to a Disclosed Scheme under which some or all of the
              benefits are payable on a final salary basis a copy of the last
              actuarial valuation;

       2.4    a copy of the audited accounts of the Disclosed Scheme for the
              last scheme year;

       2.5    a list of the Disclosed Scheme's active members setting out all
              information required to determine their respective entitlement to
              benefits under the Disclosed Scheme;

       2.6    full details of any exercise of any power or discretion under the
              Disclosed Scheme in relation to the Relevant Employees (as defined
              in Part 2 above) to augment benefits or to provide new or
              additional benefits which would not otherwise be provided or to
              admit to membership any person who would not otherwise be eligible
              for membership;

3      In relation to each Disclosed Scheme under which the amount of the
       benefits payable to or in respect of a member (other than any insured
       lump sum death in service benefits) is based solely on the amount of the
       accumulated contributions made to the Disclosed Scheme 


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       by or in respect of the member together with investment return thereon:-

       3.1    as far as the Vendor is aware no written undertaking or assurance
              has been made or given to any member of the Disclosed Scheme that
              any particular level or amount of benefit (other than insured lump
              sum death in service benefit) will be provided for or in respect
              of them under the Disclosed Scheme; and

       3.2    no contributions due to the Disclosed Scheme have fallen due but
              are unpaid.

4      Neither the Vendor nor any other employer participating in a Disclosed
       Scheme has any liability to make any payment to the Disclosed Scheme
       pursuant to section 75 Pensions Act 1995 (or otherwise) or any
       undischarged liability pursuant to Regulation 3 the Occupational Pension
       Schemes (Deficiency on Winding Up etc) Regulations 1996.

5      Every employee who has been admitted to membership or offered membership
       of a Disclosed Scheme after 31st May 1989 has been admitted to or offered
       admission on terms which comply with the requirements of Part 2 of
       Schedule 6 to the Finance Act 1989 and the substance of such terms have
       been communicated to each such employee in writing.

6      In respect of the Employees the records of each Disclosed Scheme have
       been properly and accurately maintained, there has been no such breach of
       the trusts of any Disclosed Scheme and there are not in respect of any
       Disclosed Scheme any actions suits or claims (other than routine claims
       for benefits) outstanding pending or threatened against the trustees or
       administrator of the Disclosed Scheme or against the Vendor or any other
       employer participating in the Disclosed Scheme and after making
       reasonable enquiries the Vendor is not aware of any circumstances which
       might give rise to any such claims.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


7      Each Disclosed Scheme is approved or capable of approval as an exempt
       approved scheme (within the meaning of Chapter I of Part XIV Taxes Act)
       and there is in force in respect of the employments to which the Glaxo
       Wellcome Contracted Out Money Purchase Scheme relates an appropriate
       contracting-out certificate under the Pension Schemes Act 1993.

8      In respect of the Employees each Disclosed Scheme has been administered
       in accordance with all applicable laws being all relevant statutes and
       subordinated legislation of the Parliament of the United Kingdom and all
       relevant provisions of the law of the European Communities.

9      Other than as revealed in the documents disclosed to the Purchaser
       pursuant to paragraph 2 no undertaking or assurance has been given to any
       of the Employees as to the continuance or introduction of or increase or
       improvement to any benefits under any Disclosed Scheme which the
       Purchaser will be legally required to implement.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 5

                                   Warranties

1      INFORMATION SUPPLIED

       All information contained in this agreement (other than in relation to
       the Purchaser), all matters contained in the Disclosure Letter, all other
       information relating to the Business given by the Vendor or its
       accountants or solicitors to the Purchaser or its accountants or the
       Purchaser's Solicitors or the Purchaser's Property Solicitors and the
       replies to the Purchaser's due diligence enquiries are true, accurate and
       complete in every respect and there is no fact or matter relating to the
       Business which is known to the Vendor which has not been disclosed in the
       Disclosure Letter which renders any such matters or information untrue,
       incomplete or misleading or the disclosure of which is material to be
       known by a purchaser of the Business and the Assets.

2      CAPACITY

       The Vendor has full power and authority to enter into and perform this
       agreement which constitutes a binding and enforceable obligation on the
       Vendor in accordance with its terms.

3      ACCOUNTS

       3.1    The Accounts have been carved out from the historical books and
              records of GWO as if the site was a stand alone entity and were
              prepared in accordance with the historical cost convention and
              present fairly in all material respects the assets and liabilities
              of the Business as at the Accounts Date and its profits for the
              accounting reference period ended on the Accounts Date and agree
              with the Records of the Business. The Financial Statements do not
              represent UK statutory financial statements as the site is part of
              Glaxo Operations UK Limited.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       3.2    Without limiting the generality of paragraph ? above the Accounts
              disclose all the Assets and either make full provision or reserve
              for or, as appropriate, disclose all liabilities whether actual,
              contingent, unquantified or disputed and all capital commitments
              whether actual or contingent of the Vendor and/or GWO in relation
              to the Business as at the Accounts Date.

       3.3    Any Slow-Moving Stock included in the Accounts has been written
              down appropriately and any Defective, redundant or Obsolete, Stock
              or Stock outside of its Shelf-Life has been wholly written off and
              the value attributed to the remaining Stock and Work in Progress
              does not exceed the lower of cost or net realisable value at the
              Accounts Date.

       3.4    The audited balance sheets and profit and loss accounts of GWO in
              relation to the Business for each of the accounting reference
              periods ended on the Accounts Date complied with the requirements
              of all relevant laws then in force and with all SSAP's and FRS's
              and generally accepted accounting principles of the United Kingdom
              then in force.

       3.5    The rate of depreciation adopted in the audited balance sheets of
              GWO in relation to the Business for each accounting reference
              periods ended on the Accounts Date was sufficient for each of the
              Fixed Assets of the Vendor in relation to the Business to be
              written down to nil by the end of its useful life.

       3.6    Except as stated in the audited balance sheets and profit and loss
              accounts of GWO in relation to the Business for each of the
              accounting reference periods ended on the Accounts Date no changes
              in the policies of accounting have been made therein for any of
              those periods and the method of valuing Stock and Work in Progress
              and the basis of depreciation and amortization adopted has been
              consistent during each of those periods.


                                       75
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       3.7    The profits shown by the audited profit and loss accounts of GWO
              in relation to the Business for each of the accounting reference
              periods ended on the Accounts Date have not (except as therein
              disclosed) been affected by any extraordinary or exceptional item
              or by any other factor rendering such profits for all or any of
              such periods unusually high or low.

       3.8    The Management Accounts have been prepared in accordance with
              generally accepted accounting policies and accurately state the
              assets and liabilities and turnover and profit before taxation of
              the Business for the period from 31 December 1996 to the last date
              to which management accounts are available prior to Completion.

4      POSITION SINCE  31 DECEMBER 1996

       4.1    Since 31 December 1996:-

              4.1.1  the Business has been carried on in the ordinary and usual
                     course as regards the nature, extent and manner of carrying
                     it on; and

              4.1.2  there has been no deterioration either in the financial or
                     trading position or in the prospects of the Business; and

              4.1.3  there has been no deterioration by reference to the
                     International Active suppliers Production Plan Model in the
                     expected demand for Product to be produced by the Business
                     over the period of 5 years after the Completion Date.

       4.2    Without prejudice to the generality of paragraph 4.1 since 31
              December 1996:-

              4.2.1  neither the Vendor nor GWO has in relation to the Business
                     acquired or disposed of or agreed to acquire or 


                                       76
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     dispose of any business or any material asset or assumed or
                     acquired any material liability (including a contingent
                     liability) otherwise than in the ordinary course of
                     business;

              4.2.2  GWO has paid the creditors of the Business in accordance
                     with their respective credit terms and there are no amounts
                     owing by the Vendor/GWO which have been due for more than 6
                     weeks beyond their normal credit terms;

              4.2.3  no debtor relating to the Business has been released by the
                     Vendor on terms that he pays less than the book value of
                     his debt and no debt owing to the Vendor/GWO in relation to
                     the Business has been deferred, subordinated or written off
                     or has proved to any extent irrecoverable and all book
                     debts at the date hereof are good and will be recoverable
                     in full on their respective due dates in the ordinary
                     course;

              4.2.4  neither the turnover nor the expenses (direct or indirect)
                     nor the trading position nor the margin of profitability of
                     the Business shows any material deterioration by comparison
                     with the turnover, expenses, trading position and margin of
                     profitability of the Business for the corresponding period
                     from 31 December 1995 to 31 December 1996;

              4.2.5  no contract or commitment (whether in respect of capital
                     expenditure or otherwise) has been entered into by the
                     Vendor or GWO in relation to the Business which is of an
                     unusual or long term nature or which was entered into


                                       77
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     otherwise than in the ordinary course of the Business;

              4.2.6  save in relation to the design and development work which
                     the Purchaser has agreed is necessary at the Property to
                     facilitate the production of ****, neither the Vendor nor
                     GWO has incurred nor agreed to incur any capital
                     expenditure in relation to the Business;

              4.2.7  neither the Vendor nor GWO has reduced or increased the
                     levels of stocks or raw materials and spares and
                     replacement parts in relation to the Business to a material
                     extent and such stocks are adequate for the current needs
                     of the Business.

5      TAXATION

       5.1    Neither the Vendor nor GWO is involved in any dispute with the
              Inland Revenue HM Customs & Excise or other fiscal authority
              concerning any matter which could affect the Business or any of
              the Assets in any way.

       5.2    There is no unsatisfied liability to capital transfer tax or
              inheritance tax attached or attributable to any of the Assets and
              the Assets are not subject to an Inland Revenue charge as
              mentioned in Section 237 Inheritance Tax Act 1984.

       5.3    No person has a power of sale or mortgage or the right to charge
              on any of the Assets in the circumstances mentioned in Section 212
              Inheritance Tax Act 1984.

       5.4    No security has been given over any of the Assets in favour of the
              Commissioners for Customs and Excise under the provisions of
              paragraph 4 of Schedule 11 Value Added Tax Act 1994.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       5.5    No election has been made and no election will be made on or
              before Completion under paragraph 2 of Schedule 10 Value Added Tax
              Act 1994 in relation to any of the Property.

       5.6    Neither the Vendor nor GWO has received notice of an election
              under paragraph 2 Schedule 10 Value Added Tax Act 1994 from the
              holder of any interest immediately superior to that held by the
              Vendor in respect of any of the Property.

       5.7    None of the Assets is a capital item the input tax on which may be
              subject to adjustment under Part VA Value Added Tax (General)
              Regulations 1985.

       5.8    All documents in the possession or under the control of the
              Vendor/GWO or to the production of which the Vendor/GWO is
              entitled which are necessary to establish the title of the Vendor
              to any Asset and which attract stamp duty in the United Kingdom or
              elsewhere have been properly stamped and no documents are outside
              the United Kingdom which would attract duty if they were brought
              into the United Kingdom.

6      BUSINESS NAME

       The Vendor/GWO does not use any name for any purpose in connection with
       the Business other than its full corporate name.

7      LICENCES AND CONSENTS

       The Vendor and/or GWO has obtained all licences, permissions,
       authorisations and consents required for the proper carrying on of the
       Business (details of which are set out in the Disclosure Letter). All
       such licences, permissions, authorisations and consents are in full force
       and effect and neither the Vendor nor GWO is in breach of any of the
       terms and conditions attached thereto and there are no circumstances
       known to the Vendor which indicate that any of such licences, 


                                       79
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       permissions authorisations or consents may be revoked or not renewed in
       whole or in part in the ordinary course of events nor are there any
       circumstances known to the Vendor and/or GWO which indicate that
       equivalent licences, permissions, authorisations, or consents on no less
       favourable terms would not be granted to the Purchaser following its
       acquisition of the Business.

8      THE PROPERTY AND ENVIRONMENTAL MATTERS

              Title

       8.1    The Property comprises all the land and premises and heritable
              property and rights owned, occupied or otherwise used by the
              Vendor/GWO in connection with the Business.

       8.2    GWO is the heritable proprietor of the Property and (save to the
              extent (if any) fully disclosed in the Disclosure Letter) no other
              party has any right, title or interest in or to the Property, and
              all plant and equipment and fixtures and fittings on, at, or in
              the Property are the absolute property of GWO, free from any lien
              or encumbrance.

       8.3    GWO has a good and marketable title to the Property free from all
              questions or doubts and (in particular) where GWO or its
              predecessors in title has prior to the date hereof sold off land
              adjoining or near to the Property there were excepted and reserved
              to the Vendor all necessary and appropriate servitudes and other
              rights for the benefit of the Property.

       8.4    Any information contained in the Disclosure Letter as to the terms
              of any leases or licences which have been granted over any part of
              the Property is true and accurate in all material respects.

       8.5    GWO's title has been recorded in the General Register of Sasines,
              but no application has been 


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              made in respect of the Property in the Land Register.

       8.6    The Deeds and Documents comprise all deeds or documents or written
              agreements which constitute, vary or otherwise affect GWO's title
              to the Property.

              Encumbrances

       8.7    The Property is free from any standard security, floating charge
              or other lien or charge or incumbrance securing the repayment of
              monies or other obligation or liability, whether of the Vendor/GWO
              or any other party.

       8.8    The Property is not subject to any liability for the payment of
              any outgoings other than non-domestic rates, water and sewerage
              rates, and insurance premiums.

       8.9    Save as may be disclosed in the Deeds and Documents the Property
              is not subject to any leases, burdens, restrictions, stipulations,
              servitudes, licences, grants, exceptions or reservations,
              overriding interests or other such rights the benefit of which is
              vested in third parties nor any agreement to create the same.

       8.10   Where any such matters as are referred to in Paragraphs 8.7, 8.8
              and 8.9 have been disclosed in the Disclosure Letter the
              obligations and liabilities imposed and arising under them have
              been fully observed and performed in all material respects and all
              payments in respect of them due and payable have been duly paid.

       8.11   The Property is not subject to any agreement or right to acquire
              the same nor any option right of pre-emption or right of first
              refusal and there are no outstanding actions, claims, disputes or
              demands between the Vendor and/or GWO and any 


                                       81
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              other party affecting or in respect of the Property.

       8.12   Save as disclosed in the Disclosure Letter there is no person who
              is in occupation or who has or claims any rights or servitudes of
              any kind in respect of the Property adverse to the interest, right
              or title of the Vendor or GWO therein.

              Planning Matters

       8.13   For the purposes of sub-paragraphs 8.13 to 8.24 (inclusive) of
              this paragraph 8:-

              "the Planning Acts" means

              The Town and Country Planning (Scotland) Act 1997
              The Planning (Listed Buildings and Conservation Areas) (Scotland) 
              Act 1997
              The Planning (Hazardous Substances) (Scotland) Act 1997
              The Planning (Consequences Provisions) (Scotland) Act 1997
              The Planning and Compensation Act 1991

              as the same are from time to time varied or amended and any other
              statute or subordinate legislation relating to planning matters.

       8.14   Each and every use of the Property is the permitted or lawful use
              for the purposes of the Planning Acts and no such use is subject
              to planning conditions of an onerous or unusual nature (including
              any of a personal or temporary nature).

       8.15   Planning permission has been granted or is deemed to have been
              granted for the purposes of the Planning Acts in respect of the
              development of the Property and any subsequent alteration,
              extension or other improvement of the same and no planning
              permission is of a personal or temporary nature or 


                                       82
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              has been revoked, modified or suspended or is the subject of a
              Court of Session challenge and no application for planning
              permission is either awaiting decision or the subject of any
              appeal.

       8.16   Building warrants and certificates of completion and approvals
              have been obtained in respect of the development of the Property
              and any subsequent alteration extension or other improvement of
              the same.

       8.17   Compliance is being made and has at all times been made in all
              respects with all planning permissions and building warrants for
              the time being in force in relation to the Property and with all
              orders directions and regulations made under the Planning Acts and
              the Building (Scotland) Acts.

       8.18   Save as referred to in the Disclosure Letter no agreements or
              undertakings relating to the Property have been entered into under
              the provisions of:-

              8.18.1 Sections 3A, 8, 16 or 37 of the Sewerage (Scotland) Act
                     1968;

              8.18.2 Sections 14 and 48 of the Roads (Scotland) Act 1968;

              8.18.3 Section 50 of the Town and Country Planning (Scotland) Act
                     1972 or Section 75 of the Town and Country Planning
                     (Scotland) Act 1997;

              or any similar legislation or earlier legislation of the same
              nature ("Statutory Agreements").

       8.19   Compliance is being and has at all times been made with all
              Statutory Agreements relating to the Property.


                                       83
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       8.20   No part of the Property is listed as being of special historic or
              architectural importance or located in a conservation area nor is
              the Property affected by any tree preservation orders.

       8.21   All development charges, monetary claims and liabilities under the
              Planning Acts or any other such legislation have been discharged
              and no such liability contingent or otherwise is outstanding in
              respect of the Property.

       8.22   No part of the Property is affected or likely to be adversely
              affected by any proposals contained in any structure plan, local
              plan or unitary development plan prepared or in the course of
              preparation in respect of the areas in which the Property is
              situated.

       8.23   All statements made and all information supplied by or on behalf
              of the Vendor or GWO in support of applications lodged for the
              grant of certificates of lawful existing use or development and
              certificates of lawful proposed use or development under the
              Planning Acts in respect of the Property were and remain true and
              accurate in all material respects.

       8.24   No planning contravention notices, breach of condition notices,
              enforcement notices or stop notices have been issued by any local
              planning authority in respect of the Property nor has any other
              enforcement action (including the exercise of any right of entry)
              been taken by any such authority and the Vendor is not aware of
              any circumstances which may lead to the same.

              Statutory Obligations

       8.25   Compliance is being made and has at all times been made with all
              applicable statutory and byelaw requirements with respect to the
              Property and in particular (but without limitation) with


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              requirements as to fire precautions and means of escape in case of
              fire and with requirements under the Public Health Acts, the
              Housing Acts, the Highways and Roads (Scotland) Acts, the Offices
              Shops and Railway Premises Act 1963, the Health and Safety at Work
              etc Act 1974 and the Factory Acts.

       8.26   There is no outstanding and unobserved or unperformed obligation
              with respect to the Property necessary to comply with the
              requirements (whether formal or informal) of any competent
              authority exercising statutory or delegated powers and neither the
              Vendor nor GWO anticipates that the owner of the Property will be
              obliged to incur the expenditure of any substantial sum of money
              within the next two years for such purpose.

       8.27   There are not in force or required to be in force any licences
              whether under the Licensing (Scotland) Act 1976 or otherwise which
              apply to the Property or relate to or regulate any activities
              carried on therein.

              Adverse Orders

       8.28   There are no compulsory purchase notices orders or resolutions
              affecting the Property nor is the Vendor nor GWO aware of any
              circumstances likely to lead to any being made.

       8.29   There are no closing demolition or clearance orders affecting the
              Property nor is the Vendor nor GWO aware of any circumstances
              likely to lead to any being made.

              Condition of the Property

       8.30   The buildings and other structures on the Property are in good and
              substantial repair and fit for the purposes for which they are
              presently used.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       8.31   The principal means of access to the Property are over roads which
              have been taken over by the local or other highway or roads
              authority and which are maintainable at the public expense and no
              means of access to the Property is shared with any other party nor
              subject to rights of determination by any other party and the
              Vendor and/or GWO has obtained written confirmation from the roads
              authority that all bridges on the normal route for lorry traffic
              between the Property and the A75 Trunk Road (including without
              prejudice to the generality the bridge over the railway line
              leading to the B724 public road) are fit to carry vehicles of at
              least 40 tonnes weight.

       8.32   The Property enjoys the main services of water drainage
              electricity and gas through media located entirely on in or under
              the Property and the passage and provision of such services is
              uninterrupted.

       8.33   No part of the Property is located in an area or subject to
              circumstances particularly susceptible to flooding.

       8.34   No building or structure on the Property has at any time been
              affected by structural damage or electrical defects or by timber
              infestation rising damp or disease.

       8.35   The Property is not affected by past or present mining activity.

       8.36   None of the buildings or other structures on the Property contains
              so far as the Vendor is aware in its fabric any:-

              8.36.1 high alumina cement or concrete;

              8.36.2 calcium chloride cement;

              8.36.3 calcium silicate bricks or tiles;


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              8.36.4 blue asbestos or other asbestos products;

              8.36.5 wood wool slabs in permanent shuttering form;

              8.36.6 crocidolite;

              8.36.7 untreated sea-dredged aggregates;

              8.36.8 alkali re-active aggregates;

              8.36.9 urea formaldehyde;

              8.36.10 vermiculite plaster;

              8.36.11 artificial slates;

              8.36.12 lead based paints;

              8.36.13 concrete curing accelerator;

              or any deleterious substances or any substances not approved by
              the British Standards and Codes of Practice for the time being.

              Insurance

       8.37   The Property is insured in its full reinstatement value and
              against third party and public liability claims to an adequate
              extent.

       8.38   All premiums payable in respect of insurance policies relating to
              the Property which have become due have been duly paid and no
              circumstances have arisen which would vitiate or permit the
              insurers to avoid such policies.


                                       87
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              The Grazing Lease

       8.39   The Grazing Lease has been validly executed in self-proving form,
              and the subjects thereof are as shown on the plan annexed to the
              Disclosure Letter. The Grazing Lease has not been varied in any
              respect. Neither the Tenant under the Grazing Lease nor any of the
              partners thereof nor any connected person has had any title to
              occupy any part of the Property prior to commencement of the
              Grazing Lease on 15 March 1997. No party is entitled to claim an
              agricultural tenancy in respect of the property or part thereof,
              and the heritable proprietor for the time being of the Property is
              entitled to vacant possession of the subjects of the Grazing Lease
              on 30 November 1997 without requiring to give any notice.

       8.40   Neither the Vendor nor GWO nor the tenant under the Grazing Lease
              either is or has been in breach of the Grazing Lease in any
              respect.

              The Hoddam Agreement

       8.41   The Hoddam Agreement has not been varied in any respect.

       8.42   Neither Hoddam nor GWO are or have been in breach of the Hoddam
              Agreement in any respect.

              The Water Supply

       8.43   At no time has there ever been complaint about or challenge as to
              the entitlement to the Water Supply by any party at any time since
              the Business commenced to make use of the Water Supply.

       8.44   The Vendor has a valid and marketable title to make use of the
              Water Supply without any restriction as to the quantity of water
              (other than implied by common law) and to leave in place 


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              and maintain repair, renew and replace as necessary the Pipeline.

       8.45   At no time has the quantity of water actually available from the
              Water Supply been inadequate for the requirements of the Business
              or to meet the Vendor's obligations under the Hoddam Agreement.

       8.46   Other than Hoddam in terms of Hoddam Agreement, no other party
              makes use of the Water Supply or the Pipeline.

       8.47   The Pipeline has been properly maintained by appropriate
              specialist contractors and the Vendor is aware of no defects in
              the Pipeline or repairs which might be required to the Pipeline.

       8.48   So far as the Vendor or GWO is aware the Pipeline has not been
              damaged by the action of any third party.

       8.49   The Vendor or GWO has in its possession full records showing the
              quantity of water consumed at the Property through the Water
              Supply, and will deliver same to the Purchaser at Completion.

       8.50   Neither the Vendor nor GWO has at anytime been unable to supply to
              Hoddam 1,500,000 gallons of water per day as required by the
              Hoddam Agreement.

       8.51   Neither the Vendor nor GWO has had cause to complain about the
              abstraction of water from the River Annan by any other party.

              Damage to the Property

       8.52   The Property has at no time suffered any damage or encroachment by
              sea or tidal action or flooding by either salt or fresh water.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       8.53   Neither the Vendor nor GWO has on any occasion suffered any damage
              to the Property or inconvenience to or interruption of the
              Business pursuant to the exercise of any right of access over the
              Property either pursuant to the Access Agreement or otherwise.

              Miscellaneous

       8.54   The Proprietor of the Boilerworks to the north east of the
              Property has not exercised the right conferred in Disposition by
              Northern Engineering Industries Limited in favor of Glaxo
              Properties Limited recorded in said Division of the General
              Register of Sasines on 11 June 1980 to make use of the access road
              forming part of the Property for heavy vehicular traffic.

       8.55   All the burdens and conditions contained in the Deeds and
              Documents or other title deeds of the Property have been complied
              with and, insofar as of a continuing nature, will be complied with
              by the Vendor or GWO at its own expense until the Completion Date.

       8.56   Other than in terms of the Grazing Lease, no part of the Property
              is or has during the period of ownership of occupation by any
              company in the Vendor's Group been leased to or occupied by any
              party (whether lawfully or otherwise) other than the Vendor
              itself.

       8.57   No company in the Vendor's Group, nor so far as the Vendor is
              aware any third party is or has been in dispute with any neighbour
              or other person or authority whomsoever as to the extent or
              boundaries of the Property or any neighbouring property or any
              common liabilities or title conditions affecting, or servitude
              exercisable by or against (including without prejudice to the
              generality of the Servitudes), the Property or its proprietor, or
              otherwise in respect of the 


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Property except with regard to previous grazing leases which have
              expired and whose tenants have removed and who have no further
              rights in respect of the Property.

       8.58   There are no notices, orders or proposals under the Planning Acts
              or any other public or local statutes or regulations or orders
              made thereunder or proposals or applications for statutory
              consents in relation to development affecting the Property or
              adjacent or nearby land or buildings, and no part of the Property
              or adjacent land is a SSSI or the subject of any other
              conservation, environmental or amenity designation.

       8.59   All buildings, structures, civil engineering or similar works,
              plant and equipment, machinery and fixtures and fittings on or
              comprised in the Property have been designed, constructed,
              manufactured and assembled or installed by suitably qualified and
              experienced persons in implement of written contracts which are in
              the possession of the Vendor (and which will be delivered by the
              Vendor to the Purchaser on the Completion Date), and in accordance
              with all appropriate statutory and other consents, British
              Standards and Codes of Practice, the Purchaser has not had
              occasion to make any claim against any such person, and the Vendor
              and/or GWO (as appropriate) is entitled to assign to the Purchaser
              all rights which the Vendor and/or GWO (as appropriate) shall have
              against any such person, without requiring the consent of any such
              person or other party, and the Vendor and/or GWO (as appropriate)
              holds all appropriate consents, warranties and guarantees in
              respect of any such buildings or others.

       8.60   There are no matters known to the Vendor adverse to the Property
              the disclosure of which is material to be known by a purchaser of
              the Property.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Environmental Matters

       8.61   Consents:

              8.61.1 The Vendor and/or GWO (as appropriate) holds (in its name)
                     all authorizations, permissions, consents, licences and
                     agreements necessary to enable it to carry on the Business
                     lawfully and effectively as at the date of this agreement
                     in the places and in the manner in which the Business is
                     now carried on and in particular (but without limitation):
                     to make all relevant abstractions of water; to keep, store
                     or hold all relevant substances whether as raw materials,
                     products or wastes; to carry on all relevant processes; to
                     construct and maintain all relevant buildings, plant and
                     equipment; and to hold, treat, manage, consign and dispose
                     of all waste materials, substances, gases and effluents in
                     the relevant manner and knows of no circumstances which
                     would require additional authorizations, permissions,
                     consents, licences and agreements to be obtained following
                     Completion if the Business was carried on after Completion
                     in the same way and to the same extent as before
                     Completion.

              8.61.2 All such authorizations, permissions, consents, licences
                     and agreements have been lawfully obtained and are in full
                     force and effect.

              8.61.3 No further authorizations, permissions, consents, licences
                     and agreements are necessary to enable the Purchaser to
                     carry on the Business as now or since 31 December 1996
                     conducted.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              8.61.4 Without prejudice to paragraphs 8.61.1, 8.61.2 and 8.61.3
                     details of all authorizations, permissions, consents,
                     licences and agreements of the types referred to in
                     paragraph 8.61.1 are set out in the Disclosure Letter
                     (including details of the renewal dates).

              8.61.5 The Vendor and each member of the Vendor's Group has in
                     relation to the Business complied at all times in all
                     respects with all conditions attaching to the
                     authorizations, permissions, consents, licences and
                     agreements referred to in paragraph 8.61.1 (whether such
                     conditions are imposed expressly or are implied by law) and
                     there are no circumstances known to the Vendor which would
                     render it impracticable for the Purchaser to comply with
                     those conditions in the future.

              8.61.6 Neither the Vendor nor any member of the Vendor's Group has
                     in relation to the Business received written notice,
                     correspondence or communication in any other form in
                     respect of any of the authorizations, permissions,
                     consents, licences or agreements referred to above
                     revoking, suspending, modifying or varying any of them and
                     there are no circumstances known to the Vendor which might
                     give rise to such notice being received or of any intention
                     on the part of any relevant authority to give any such
                     notice.

       Compliance with environmental protection laws

       8.62   Neither the Vendor nor any member of the Vendor's Group nor any of
              their officers, agents or employees have committed, in relation to
              the 


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Business or the Property and whether by act or omission, any
              breach of Environmental Laws, and they have conformed at all times
              with all relevant codes of practice, guidance notes, standards and
              other advisory material issued by any competent authority.

       8.63   Neither the Vendor nor any member of the Vendor's Group has in
              relation to the Business or the Property received any notice,
              order or other communication from any relevant authority in
              respect of a failure to comply with any Environmental Laws and
              there are no circumstances which might give rise to such notice,
              order or other communication being received nor is the Vendor
              aware of any intention on the part of any such authority to give
              such notice.

       8.64   Civil liability

              8.64.1 There is no actual or potential liability on the part of
                     the Vendor or any member of the Vendor's Group arising from
                     any activities or operations of the Business or the state
                     or condition of any properties now or formerly owned or
                     occupied by the Vendor or any member of the Vendor's Group
                     in relation to the Business or facilities now or formerly
                     used by the Vendor or any member of the Vendor's Group in
                     relation to the Business and in particular (but without
                     limitation) any such liability in respect of: injury to
                     persons (including impairment of health or interference
                     with amenity); damage to land or personal property;
                     interference with riparian or other proprietary or
                     possessory rights; public or private nuisance; liability
                     for waste or other substances; and damage to or impairment


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     of the environment including living organisms.

              8.64.2 Neither the Vendor nor any member of the Vendor's Group is
                     in relation to the Business engaged in any litigation,
                     arbitration or dispute resolution proceedings relating to
                     any actual or potential liability in respect of any matter
                     covered by paragraph 8.64.1 and the Vendor is not aware of
                     any such litigation or proceedings pending or being
                     threatened nor is the Vendor aware of any circumstances or
                     facts likely to give rise to such litigation, arbitration
                     or proceedings.

              8.64.3 Neither the Vendor nor any member of the Vendor's Group is
                     subject to any injunction, interdict or similar remedy or
                     order by a court of competent jurisdiction, or to any
                     undertaking given to such court, in respect of matters
                     referred to in this paragraph 8.64.

              8.64.4 No notification has been (or in accordance with the terms
                     of the relevant policies of insurance should have been)
                     made to the Vendor's or GWO's insurers of any matters
                     specified in this paragraph 8.64.

       8.65   Condition of the Property

              8.65.1 No notice or other communication has been received from any
                     relevant authority relating to the physical condition of
                     the Property nor so far as the Vendor is aware is there any
                     circumstance likely to give rise to the


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     service of any such notice or communication.

              8.65.2 The Property has not been used for the deposit of waste
                     controlled by any legislation during the ownership or
                     occupation of the Vendor or any member of the Vendor's
                     Group and neither the Vendor nor any member of the Vendor's
                     Group is aware of any such use before its ownership or
                     occupation.

       8.66   Internal policy assessments and plans

              8.66.1 Details of all the Vendor's and GWO's statements of
                     corporate environmental policy and operating procedures are
                     set out in the Disclosure Letter.

              8.66.2 The Vendor and any other relevant company in the Vendor's
                     Group have complied with all its statements of corporate
                     environmental policy and operating procedures.

              8.66.3 The Vendor and each other relevant company in the Vendor's
                     has properly carried out and made all such assessments or
                     plans as are required by law in relation to the substances,
                     processes, operations and wastes (including without
                     limitations those relating to hazardous substances,
                     accident hazards, releases to the environment and noise) of
                     the Business; proper records have been kept of such
                     assessments and plans and the Vendor knows of no
                     circumstances which would render such appraisals or plans
                     incorrect or subject to revision.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              8.67   Any replies given by or on behalf of the Vendor and/or GWO
                     to enquiries before contract raised by or on behalf of the
                     Purchaser relating in any way to the Property are true,
                     complete and accurate in all respects and contain all
                     information known or available to the Vendor's Group in
                     response to the enquiries.

9      ASSETS

       9.1    The Vendor is the legal and beneficial owner having possession of
              and with good and marketable title to all the Assets and all the
              assets required to carry on the Business are included in the sale
              hereunder and are in the possession or under the control of the
              Vendor.

       9.2    None of the Assets is the subject of any Encumbrance.

       9.3    The Vendor has not created any Encumbrance on over or affecting
              any part of the Assets and there is no agreement or commitment to
              give or create any Encumbrance and no claim has been made by any
              person to be entitled to any Encumbrance.

       9.4    All the plant, machinery, equipment and vehicles of the Vendor
              relating to the Business are in good repair and working order and
              have been regularly and properly maintained and no substantial
              repairs are in hand or are necessary and none of the plant,
              machinery, equipment or vehicles is out of date, dangerous (by
              reason of its state of repair), not fit for its purpose,
              unsuitable or in need of renewal or replacement or fails to comply
              with the applicable safety standards.

       9.5    The List of Fixed Plant and the List of Equipment comprise a
              complete and accurate record of all the plant and equipment (with
              a value of(pounds)50,000 or more), machinery, equipment and
              vehicles owned or possessed by the Vendor in relation to the


                                       97
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Business and necessary for the continuation of the Business.

       9.6    There are no Assets used in the Business which are not situate at
              the Property.

10     STOCK

       10.1   All the Stock can be used in the Business.

       10.2   The Stock is sufficient for the normal requirements of the
              Business.

       10.3   The Stock is at its normal level having regard to current orders.

11     INSURANCE

       11.1   Full details of all insurance policies effected in relation to the
              Business have been disclosed to the Purchaser and all such details
              are true and correct in all respects and all such insurance
              policies are currently in full force and effect.

       11.2   Neither the Vendor nor GWO has done or omitted to do or suffered
              anything to be done or not to be done which has or might render
              any policies of insurance taken out by it void or voidable or
              which would or might result in an increase in the rate of premiums
              on the said policies and there are no circumstances of which the
              Vendor is aware which would or might give rise to any claim under
              any of such policies of insurance.

       11.3   There is now and has at all times been adequate insurance in
              respect of the Business against fire, accident, damage, injury,
              third party loss (including product liability) loss of profits and
              other risks normally covered by insurance (including such risks as
              companies carrying on the same type of business as the Business
              commonly cover by insurance).


                                       98
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


12     RECORDS

       The records and books of account of the Vendor and GWO relating to the
       Business are duly entered up and contain true, full and accurate records
       of all matters to be dealt with therein and do not contain any material
       inaccuracies or discrepancies. All books and all records and documents of
       the Vendor and GWO relating thereto which are its property are in the
       possession or under the control of a company within the Vendor's Group.

13     CONFIDENTIAL INFORMATION

       13.1   Neither the Vendor nor GWO uses in the Business any processes and
              is not engaged in the Business in any activities which involve the
              misuse of any Confidential Information belonging to any third
              party.

       13.2   The Vendor is not aware of any actual or alleged misuse by any
              person of any of its Confidential Information.

       13.3   Neither the Vendor nor GWO has disclosed to any person any of its
              Confidential Information except where such disclosure was properly
              made in the normal course of the Business and was made subject to
              an agreement under which the recipient was obliged to maintain the
              confidentiality of such Confidential Information and was
              restrained from further disclosing or using it other than for the
              purposes for which it was disclosed by the Vendor or GWO.

       13.4   Confidential Information used by the Vendor or GWO is kept
              strictly confidential and the Vendor and GWO operate and fully
              complies with procedures which maintain such confidentiality which
              confidentiality has not been breached.


                                       99
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


14     INTELLECTUAL PROPERTY

       14.1   The Vendor is the sole unencumbered legal and beneficial owner and
              where registered the sole registered proprietor of all the
              Intellectual Property.

       14.2   The material particulars as to ownership registration (and
              applications therefor) of the Intellectual Property (if any) are
              set out in the Disclosure Letter and such details are complete and
              correct. Such Intellectual Property comprises all Intellectual
              Property which the Purchaser will require in order fully to carry
              on and exploit the Business and deal with the Assets sold and
              purchased hereunder.

       14.3   None of the Intellectual Property is currently being infringed by
              any third party or has been so infringed in the 6 year period
              preceding the Completion Date and no third party has threatened
              any such infringement.

       14.4   Save for those agreements listed in the Disclosure Letter the
              carrying on of the Business as presently constituted does not
              require any licences or consents from or the making of royalty or
              similar payments to any third party and the Vendor is not engaged
              in any activities which and none of the Vendor's processes or
              products infringe any Intellectual Property belonging to any third
              party. All such listed agreements (and each provision thereof) are
              valid and subsisting and not restricted in any way and the Vendor
              is not in breach of any of the provisions thereof.

       14.5   There are no outstanding claims against the Vendor for
              infringement of any Intellectual Property used (or which has been
              used) by it in the Business and no such claims have been settled
              by the giving of any undertakings which remain in force.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       14.6   There is no Intellectual Property required for the carrying on of
              the Business which is not exclusively used in respect of the
              Business or which is being licensed to the Purchaser.

15     COMPUTER SYSTEMS

       15.1   The Computer Systems have been satisfactorily maintained and have
              the benefit of the maintenance agreements listed in the Disclosure
              Letter or in the Information Technology Services Agreement.

       15.2   Disaster recovery plans are in effect and in the opinion of the
              Vendor's directors are adequate for its present needs to ensure
              that the Computer Systems can be replaced or substituted without
              material disruption to the Business.

       15.3   In the event that any person providing maintenance or support
              services for the Computer Systems ceases or is unable to do so,
              the Vendor has all necessary rights to obtain the source code and
              all related technical and other information to procure the
              carrying out of such services by its own employees or by a third
              party.

       15.4   The Vendor has adequate procedures for its present needs to ensure
              internal and external security of the Computer Systems, including
              procedures for taking and storing, on-site and off-site, back-up
              copies of computer programs and data.

       15.5   None of the records, systems, controls, data or information
              relating to the Business are recorded, stored, maintained,
              operated or otherwise wholly or partly dependent upon or held by
              any means (including any electronic, mechanical or photographic
              processes whether computerized or not) which (including all means
              of access thereto and therefrom) are not under the exclusive
              ownership and direct control of the Vendor.


                                      101
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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


16     DATA PROTECTION

       The Vendor and GWO (as applicable) has complied with all relevant
       requirements of the Data Protection Act 1984, in relation to the Business
       including:

       16.1   the data protection principles established in that Act;

       16.2   request from data subject for access to data held by it; and

       16.3   the requirements relating to the registration of data users.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


17     REPAYMENT LIABILITIES

       Neither the Vendor nor GWO has received any notice to repay any monies or
       liabilities which are repayable on demand and no default or event
       entitling any person with or without giving any formal notice and whether
       immediately or after expiry of any notice to demand or accelerate
       repayment appoint a receiver or take any other action to protect his
       security has occurred in relation to any agreement relating to any
       borrowing or indebtedness or security given by the Vendor or GWO in
       relation to the Business.

18     EMPLOYEES

       18.1   None of the Employees has given or received notice terminating his
              employment or will be entitled to give notice as a result of the
              provisions of this agreement.

       18.2   Full particulars of the terms and conditions of employment of all
              the Employees (including without limitation all remuneration
              incentives bonuses expenses and other payments and benefits
              whatsoever payable) are set out in the Disclosure Letter.

       18.3   There is not in existence any contract of employment with
              directors or employees of the Vendor (or any contract for services
              with any individual) relating to the Business which cannot be
              terminated by 3 months' notice or less without giving rise to a
              claim for damages or compensation (other than a statutory
              redundancy payment or statutory compensation for unfair
              dismissal).

       18.4   In relation to each of the Employees (and so far as relevant to
              each of its Excluded Employees and/or former employees) the Vendor
              has:-


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separately with the Commission.


              18.4.1 complied with all obligations imposed on it by Articles of
                     the Treaty of Rome European Commission Regulations and
                     Directives and all statutes regulations and codes of
                     conduct relevant to the relations between it and the
                     Employees or it and any recognized trade union;

              18.4.2 maintained adequate and suitable records regarding the
                     service of each of the Employees;

              18.4.3 complied with all collective agreements and customs and
                     practices for the time being dealing with such relations or
                     the conditions of service of the Employees; and

              18.4.4 complied with all relevant orders and awards made under any
                     statute affecting the conditions of service of its
                     Employees.

       18.5   The Vendor nor any other company in the Vendor's Group is involved
              in any industrial or trade disputes and to the best of the
              Vendor's knowledge information and belief there are no
              circumstances which may result in any industrial dispute involving
              any of the Employees and to the best of the Vendor's knowledge
              information and belief none of the provisions of this agreement
              including the identity of the Purchaser is likely to lead to any
              industrial dispute.

       18.6   There is not outstanding any agreement or arrangement to which the
              Vendor nor any other company in the Vendor's Group is party in
              relation to the Business for profit sharing or for payment to any
              of its employees of bonuses or for incentive payments or other
              similar matters.


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confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       18.7   Since 31 December 1996 no change has been made in the terms of
              employment by the Vendor of any of the Employees.

       18.8   Save as disclosed in the Disclosure Letter the Vendor nor any
              other company in the Vendor's Group has not entered into any
              recognition agreement with a trade union in respect of the
              Employees nor has it done any act which may be construed as
              recognition.

       18.9   The Vendor and GWO have complied with all recommendations made by
              the Advisory Conciliation and Arbitration Service and with all
              awards and declarations made by the Central Arbitration Committee.

       18.10  There is no agreement, arrangement, scheme or obligation (whether
              legal or moral) for the payment of any pensions, allowances, lump
              sums or other like benefits on retirement or on death or during
              periods of sickness or disablement for the benefit of any of the
              Employees or for the benefit of dependents of such persons save as
              disclosed in the Disclosure Letter.

       18.11  No amounts due to or in respect of any of the Employees (including
              PAYE and national insurance and pension contributions) are in
              arrear or unpaid.

       18.12  No monies or benefits other than in respect of contractual
              emoluments are payable to any of the Employees and there is not at
              present a claim occurrence or state of affairs which may hereafter
              give rise to a claim against the Vendor or GWO arising out of the
              employment or termination of employment of any employee for
              compensation for loss of office or employment or otherwise and
              whether under the Employment Rights Act 1996 Equal 


                                      105
<PAGE>   112

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              Pay Act 1970, Sex Discrimination Act 1975, Sex Discrimination Act
              1986, Disability Discrimination Act 1995 or any other act or
              otherwise.

19     CONTRACTS

       19.1   There is not outstanding in connection with the Business:-

              19.1.1 any agreement or arrangement between the Vendor or GWO and
                     any third party which the signature or performance of this
                     agreement will contravene or under which the third party
                     will acquire a right of termination or any option as a
                     result of the signature or performance of this agreement;

              19.1.2 any agency, distributorship, marketing, purchasing,
                     manufacturing or licensing agreement or arrangement or any
                     restrictive trading or other agreement or arrangement
                     pursuant to which any part of the Business has been carried
                     on;

              19.1.3 any agreement or arrangement in relation to the Business
                     between the Vendor or GWO and any other company which is a
                     member of the Group;

              19.1.4 any agreement or arrangement entered into by the Vendor or
                     GWO otherwise than by way of bargain at arm's length and in
                     the normal and ordinary course of the Business; or

              19.1.5 any sale or purchase option or similar agreement or
                     arrangement affecting any of the Assets or by which the
                     Vendor or 


                                      106
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     GWO is bound in relation to the Business.

       19.2   None of the Contracts contain are unprofitable (that is to say
              known to have been likely to result in a loss to the Vendor on
              completion of performance if the Vendor had not sold the Business)
              or of a long term nature (that is to say incapable of performance
              in accordance with its terms within 6 months after the date on
              which it was entered into or undertaken).

       19.3   No party with whom the Vendor or GWO has entered into any
              agreement or arrangement in connection with the Business is in
              default thereunder being a default which would have a material and
              adverse effect on the financial or trading position or prospects
              of the Business and so far as the Vendor is aware there are no
              circumstances likely to give rise to such a default.

       19.4   Neither the Vendor nor GWO has any knowledge of the invalidity of
              or grounds for rescission, avoidance or repudiation of any of the
              Contracts and has not received notice of intention to terminate
              any of the Contracts.

       19.5   Neither the Vendor nor GWO has any reason to believe that any
              supplier of the Vendor or GWO or other person dealing with the
              Vendor or GWO in connection with the Business will refuse to deal
              with the Purchaser in connection with the Business or will deal
              with it on a smaller scale than with the Vendor or GWO as a result
              of the signature or performance of this agreement.

       19.6   Details of all tenders which have been made by the Vendor or GWO
              in connection with the Business and which have not yet been
              accepted but are capable of acceptance are contained in the
              Disclosure Letter.


                                      107
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


20     BORROWINGS

       Except as disclosed in the Accounts neither the Vendor nor GWO has
       outstanding in connection with the Business:-

       20.1   any borrowing or indebtedness in the nature of borrowing including
              any bank overdrafts liabilities under acceptances (otherwise than
              in respect of normal trade bills) and acceptance credits other
              than borrowing or indebtedness arising in the ordinary course of
              business;

       20.2   any guarantee indemnity or undertaking (whether or not legally
              binding) to procure the solvency of any person or any similar
              obligation; or

       20.3   any mortgage charge lien pledge or any obligation (including a
              conditional obligation) to create a mortgage charge lien or
              pledge.

21     LITIGATION OFFENCES AND COMPLIANCE WITH STATUTES

       21.1   Neither the Vendor nor any other company in the Vendor's Group is
              plaintiff, defendant (save where it has no knowledge any
              proceedings to be served on it) pursuer or defender or otherwise a
              party to any litigation, arbitration or administrative proceedings
              in connection with the Business which are in progress or are
              threatened or pending by or against or concerning the Vendor or
              any of the Assets the Vendor is not being prosecuted for any
              criminal offence in connection with the Business, no governmental
              or official investigation or inquiry concerning the Business or
              any of the Assets is in progress or pending and so far as the
              Vendor is aware there are no circumstances which are likely to
              give rise to any such proceedings, investigation or inquiry.

       21.2   Neither the Vendor nor any other company in the Vendor's Group nor
              any of its officers, employees 


                                      108
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              or, so far as the Vendor is aware, its agents (during the course
              of their duties in relation to the Business) has committed or
              omitted to do any act or thing the commission or omission of which
              is or could be in contravention of any statutory obligation or any
              other law of the United Kingdom or any part thereof or any other
              country giving rise to any fine, penalty, default, proceedings or
              other liability in relation to the Business or any of the Assets
              or any judgment or decision which would materially affect the
              financial or trading position or prospects of the Business.

       21.3   Neither the Vendor nor any other company in the Vendor's Group has
              done or agreed to do anything as a result of which either any
              investment or other grant paid to the Vendor in relation to the
              Business is or may be liable to be refunded in whole or in part or
              any such grant for which application has been made by it will or
              may not be paid or may be reduced.

       21.4   There is not outstanding in relation to the Business any liability
              for industrial training levy or for any other statutory or
              governmental levy or charge.

22     RESTRICTIVE AGREEMENTS

       22.1   There are no agreements in force to which the Vendor nor any other
              company in the Vendor's Group is a party directly or indirectly
              affecting the Business which would restrict the freedom of the
              Purchaser to provide and take goods and services by such means and
              from and to such persons as it may from time to time think fit.

       22.2   Neither the Vendor nor any other company in the Vendor's Group is
              nor has it been party to any agreement, arrangement, concerted
              practice or course of conduct directly or indirectly affecting the
              Business which:-


                                      109
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              22.2.1 is or ought to be or ought to have been or requires to be
                     registered under the Restrictive Trade Practices Acts 1976
                     and 1977 or contravenes the provisions of the Resale Prices
                     Act 1976 or is or has been the subject of any inquiry,
                     investigation or proceeding under any of these Acts;

              22.2.2 is or has been the subject of an inquiry, investigation,
                     reference or report under the Fair Trading Act 1973 (or any
                     previous legislation relating to monopolies or mergers) or
                     the Competition Act 1980; or

              22.2.3 contravenes Article 85(1) or 86 of the Treaty of Rome or
                     which has been notified to the Commission of the European
                     Community for an exemption or in respect of which an
                     application has been made to the said Commission for a
                     negative clearance or infringes any regulation or other
                     enactment made under Article 87 of the said Treaty or is or
                     has been the subject of any inquiry, investigation or
                     proceeding in respect thereof;

              22.2.4 has or is intended to have or is likely to have the effect
                     of restricting, distorting or preventing competition in
                     connection with the production, supply or acquisition of
                     goods in the United Kingdom or any part of it or the supply
                     or securing of services in the United Kingdom or any part
                     of it.

              22.2.5 is by virtue of its terms or by virtue of any practice for
                     the time being carried on in connection therewith a
                     "Consumer Trade Practice" within the 


                                      110
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                     meaning of section 13 of the Fair Trading Act 1973 and
                     susceptible to or under reference to the Consumer
                     Protection Advisory Committee or the subject matter of a
                     report to the Secretary of State or the subject matter of
                     an Order by the Secretary of State under the provisions of
                     Part II of that Act; or

              22.2.6 infringes any other competition, anti- restrictive trade
                     practice, anti-trust or consumer protection law or
                     legislation applicable in the United Kingdom or elsewhere
                     and not specifically mentioned in this paragraph.

       22.3   Neither the Vendor nor any other company in the Vendor's Group has
              in connection with any matter directly or indirectly affecting the
              Business given any assurance or undertaking to the Restrictive
              Practices Court or the Director General of Fair Trading or the
              Secretary of State for Trade and Industry or the Commission or the
              Court of Justice of the European Communities or any other court,
              person or body and is not subject to any act, decision, regulation
              or other instrument made by any of them relating to any matter
              referred to in this sub-paragraph 24.3.

       22.4   Neither the Vendor nor any other company in the Vendor's Group is
              in default or in contravention of any article, act, decision,
              regulation or other instrument or of any undertaking relating to
              any matter referred to in sub-paragraph 23.2 ("the Anti-Trust
              Rules") and has received no complaint or threat to complain under
              or referring to the Anti-Trust Rules from any person and has not
              received any request for information, investigation or objection
              relating to the Anti-Trust Rules or been party to any proceedings
              to 


                                      111
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


              which the Anti-Trust Rules (or any of them) were pleaded or relied
              upon.

       22.5   Neither the Vendor nor any other company in the Vendor's Group is
              in relation to the Business in a dominant position in any market
              in any substantial part of the EEC for the purposes of Article 86
              of the Treaty of Rome.

23     EFFECTS OF THIS AGREEMENT

       Neither this agreement nor completion thereof:-

       23.1   conflicts with or will or may result in the breach of or
              constitute a default under or give rise to any right of
              termination or acceleration of payment or additional liability
              under any agreement, instrument, order, judgment, award,
              injunction, decree or regulation or any restriction of any kind to
              which a member of the Vendor's Group is a party; nor

       23.2   will or may relieve any other party to any of the Contracts of its
              obligations thereunder or enable it to determine such obligations
              or any of them to the Purchaser's detriment or to the detriment of
              the Business.

24     DEFECTIVE PRODUCTS

       Neither the Vendor nor any member of the Vendor's Group has in relation
       to the Business sold or supplied prior to Completion any products which
       are or were in any respect faulty or defective or which do not comply
       with any warranties or representations expressly or implied made.

25     REORGANIZATION

       Details of the transfer in 1995 of the Business and associated assets
       from Glaxochem Limited to GWO and in 


                                      112
<PAGE>   119

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       1997 from GWO to the Vendor are contained in the Disclosure Letter.


                                      113
<PAGE>   120

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 6

                        Limitations to Vendor's Liability


1       The provisions of this Schedule shall operate to limit the liability of
        the Vendor under the warranties contained in Schedule 5 and references
        to "liability" or "liabilities" shall be construed accordingly.

2       The Vendor shall not be liable for any claim in respect
        of any Relevant Claim:

        2.1      unless the aggregate amount of all Relevant Claims
                 for which the Vendor would otherwise be liable
                 exceeds (pounds)100,000;

        2.2      to the extent that the total liability of the
                 Vendor in respect of all Relevant Claims would
                 exceed ****;

        2.3      unless the Purchaser has given the Vendor written
                 notice of the Relevant Claim (stating in
                 reasonable detail the nature of the Relevant Claim
                 and, if practicable, the amount claimed) on or
                 before the date which is 30 days after the date of
                 receipt of the audited accounts of the Purchaser
                 for the financial period ended 31 December 1999.

        If the aggregate amount of the Relevant Claims exceeds (pounds)100,000
        the Vendor shall be liable for the full amount and not just the excess
        above (pounds)100,000.

3      A Relevant Claim notified in accordance with paragraph 2.3 and not
       satisfied, settled or withdrawn is unenforceable against the Vendor, on
       the expiry of twelve (12) months starting on the day of notification of
       the Relevant Claim unless proceedings in respect of the Relevant Claim
       have been issued and served on the Vendor.


                                      114
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Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


4      The Vendor shall not be liable in respect of a Relevant Claim:

       4.1    if and to the extent that the matter giving rise to the Relevant
              Claim would not have arisen but for the passing of, or a change
              in, after the date of Completion a law, regulation or
              administrative practice of a government, government department,
              agency or regulatory body, in each case not actually or
              prospectively in force at the date of this agreement;

       4.2    if and to the extent that the matter giving rise to the Relevant
              Claim is an amount for which the Purchaser's Group has recovered
              from any person (other than the Vendor), whether under a provision
              of applicable law, insurance policy or otherwise;

       4.3    if and to the extent that the matter giving rise to the Relevant
              Claim would not have arisen but for an act omission or transaction
              of the Purchaser or an officer of the Purchaser which was outside
              the ordinary course of the Business which it or he should
              reasonably have known would give rise to such liability.

5      The Purchaser shall not be entitled to recover more than once in respect
       of the same loss.

6      The Purchaser shall as soon as reasonably practicable give written notice
       to the Vendor of any matter which it becomes aware which is likely to
       give rise to a Relevant Claim and whether the Purchaser considers it may
       have any remedy against any third party and shall consult with the Vendor
       in respect to the matter. If the Purchaser fails, for whatever reason, to
       comply with the terms of this clause any such failure shall not affect
       the Purchaser's ability to make a Relevant Claim.

7      If the Purchaser becomes aware of a matter which might give rise to a
       Relevant Claim and if such claim is as a 


                                      115
<PAGE>   122

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       result of or in connection with a claim by or a liability to a third
       party:

       7.1    the Purchaser shall (subject to any obligations as to
              confidentiality to third parties) provide to the Vendor and its
              advisors reasonable access, by prior arrangement, to premises and
              personnel and to relevant assets, documents and records within the
              power or control of the Purchaser's Group for the purposes of
              investigating the matter and enabling the Vendor to take the
              action referred to in paragraph 7.4;

       7.2    the Vendor (at its cost) may by prior arrangement take copies of
              the documents and records and photograph the premises or assets
              referred to in paragraph 7.2;

       7.3    the Purchaser shall (save where any such action would be
              prejudicial to the Business) take any action and institute any
              proceedings and give any information and assistance, as the Vendor
              may reasonably request to dispute, resist, appeal, compromise,
              defend, remedy, settle or mitigate the matter or enforce against a
              person, (other than a member of the Vendor's Group) the rights of
              the Purchaser in relation to the matter in connection with
              proceedings related to the matter (other than against a member of
              the Vendor's Group) and the Vendor shall indemnify the Purchaser
              for all reasonable costs incurred as a result of any such request
              by the Vendor;

       7.4    the Purchaser shall not, and shall ensure that no member of the
              Purchaser's Group will, admit liability in respect of, compromise
              or settle the matter without the prior written consent of the
              Vendor (not to be unreasonably withheld or delayed).

8      If the Vendor pays to the Purchaser an amount in respect of a Relevant
       Claim and the Purchaser or any 


                                      116
<PAGE>   123

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


       member of the Purchaser's Group subsequently recovers from a third party
       an amount which is referable to the matter giving rise to the Relevant
       Claim then:

       8.1    if the amount paid by the Vendor in respect of the Relevant Claim
              is more than the sum recovered from the third party, the Purchaser
              shall as soon as practicable pay the Vendor the sum so recovered;
              and

       8.2    if the amount paid by the Vendor in respect of the Relevant Claim
              is less than or equal to the sum recovered from the third party,
              the Purchaser shall as soon as practicable pay the Vendor an
              amount equal to the amount paid by the Vendor;

9      For the purposes of this paragraph the "sum recovered" means an amount
       equal to the amount recovered from the third party less all reasonable
       costs and expenses incurred by the Purchaser or any member of the
       Purchaser's Group in recovering the amount from the third party.

10     Nothing in this part of this Schedule restricts or limits the Purchaser's
       general obligations to mitigate any loss or damage which it may incur in
       consequence of a matter giving rise to a Relevant Claim.


                                      117

<PAGE>   1

                            DATED 30th OCTOBER, 1997


                            CHIREX (HOLDINGS) LIMITED
                                   as Borrower


                                   CHIREX INC.
                             CHIREX (DUDLEY) LIMITED
                             CHIREX (ANNAN) LIMITED
                                  as Guarantors


                         BANKERS TRUST INTERNATIONAL PLC
                                MIDLAND BANK PLC
                               as Joint Arrangers


                              BANKERS TRUST COMPANY
                                    as Agent


                              BANKERS TRUST COMPANY
                                as Security Agent


                                       and


                          THE LENDERS DESCRIBED HEREIN

                          ----------------------------

                              FACILITIES AGREEMENT

                                 GBP 62,000,000
                          ----------------------------


                              O'MELVENY & MYERS LLP
                               10 Finsbury Square
                                 London EC2A 1LA

                              Tel: +44 171 256 8451
                              Fax: +44 171 638 8205
<PAGE>   2

                                TABLE OF CONTENTS

1.   INTERPRETATION............................................................3

2.   THE FACILITIES...........................................................28

3.   PARTICIPATION OF LENDERS.................................................29

4.   CONDITIONS PRECEDENT.....................................................33

5.   DRAWDOWN PROCEDURES......................................................36

6.   REPAYMENT OF ADVANCES....................................................38

7.   PREPAYMENT...............................................................39

8.   INTEREST.................................................................42

9.   PAYMENTS.................................................................45

10.  CHANGE IN CIRCUMSTANCES..................................................48

11.  FEES, EXPENSES AND STAMP DUTIES..........................................51

12.  REPRESENTATIONS AND WARRANTIES...........................................53

13.  UNDERTAKINGS.............................................................61

14.  EVENTS OF DEFAULT........................................................78

15.  GUARANTEE................................................................83

16.  THE AGENT AND THE OTHER FINANCE PARTIES..................................86

17.  EVIDENCE OF INDEBTEDNESS.................................................93

18.  APPLICATION OF MONEYS....................................................93

19.  PRO RATA PAYMENTS........................................................94

20.  SET-OFF..................................................................95

21.  NOTICES..................................................................95

22.  NO IMPLIED WAIVERS.......................................................96

23.  INVALIDITY OF ANY PROVISION..............................................96

24.  CONFIDENTIALITY..........................................................96

25.  CHANGES TO PARTIES.......................................................96


                                       (i)
                                                                   Executed Copy
<PAGE>   3

26.  LENDER DECISIONS.........................................................99

27.  INDEMNITIES..............................................................99

28.  CERTIFICATES CONCLUSIVE.................................................101

29.  GOVERNING LAW...........................................................101

30.  JURISDICTION............................................................101

31.  COUNTERPARTS............................................................102


SCHEDULE 1
     Commitments and Lending Offices......................................S1 - 1

SCHEDULE 2
     Repayment Schedule...................................................S2 - 1

SCHEDULE 3
     Form of Drawdown Request.............................................S3 - 1

SCHEDULE 4
     Structure of ChiRex Group............................................S4 - 1

SCHEDULE 5
     Calculation of the Mandatory Liquid Asset Costs
         for any Sterling Advances........................................S5 - 1

SCHEDULE 6
     Form of Deed of Accession............................................S6 - 1

SCHEDULE 7
     Form of Transfer Certificate.........................................S7 - 1
     First Schedule to the Transfer Certificate...........................S7 - 4
     Second Schedule to the Transfer Certificate..........................S7 - 5

SCHEDULE 8
     Continuing Indebtedness..............................................S8 - 1


                                      (ii)
                                                                   Executed Copy
<PAGE>   4

THIS AGREEMENT ("Agreement") is made on 30th October, 1997

AMONG:-

(1)    CHIREX (HOLDINGS) LIMITED, a limited company organised under the laws of
       England with registered number 3080257 with its registered office at
       Dudley, Cramlington, Northumberland NE23 7QG;

(2)    CHIREX INC., a corporation organised under the laws of the State of
       Delaware with its principal office at 300 Atlantic Street, Suite 402,
       Stamford, CT 06901, U.S.A., CHIREX (DUDLEY) LIMITED., a limited company
       organised under the laws of England with registered number 857670 with
       its registered office at Dudley, Cramlington, Northumberland NE23 7QG,
       and CHIREX (ANNAN) LIMITED., a limited company organised under the laws
       of England with registered number 3417229 with its registered office at
       Dudley, Cramlington, Northumberland NE23 7QG;

(3)    BANKERS TRUST INTERNATIONAL PLC and MIDLAND BANK PLC, as Joint Arrangers;

(4)    BANKERS TRUST COMPANY, as Agent;

(5)    BANKERS TRUST COMPANY, as Security Agent; and

(6)    THE LENDERS DESCRIBED HEREIN.

IT IS AGREED as follows:-

1.     INTERPRETATION

1.1    Definitions

       In this Agreement, unless the context requires otherwise, the following
       expressions shall have the following meanings:-

       "Accountants' Report" means the reports prepared by Arthur Andersen
       relating to analysis of costs of certain operations in the U.K. of the
       ChiRex Group, together with the letter in respect thereof dated 16th
       October, 1997, each addressed to and for the benefit of, inter alia, the
       Finance Parties;

       "Achievement Date" means the later of (i) 31st December, 1998 or (ii) the
       first Accounting Quarter end following the date of this Agreement as at
       which the Total


                                        3
                                                                   Executed Copy
<PAGE>   5

       Debt/EBITDA Ratio, calculated as provided in Clause 13.4, is 2:1 or
       lower;

       "Accounting Quarter" means, subject to Clause 13.3, each successive
       fiscal period of the ChiRex Group consisting of three consecutive months;

       "Accounting Reference Period" means each successive financial year of the
       ChiRex Group ending on or about 31st December, as such ending date may be
       altered in accordance with Clause 13.3;

       "Advance" means the principal amount of the borrowing made or to be made
       by the Borrower on a Drawdown Date under any of the Facilities (and
       includes a WCP Advance) or, as the context requires, the principal amount
       thereof for the time being outstanding;

       "Advisory Capacity" has the meaning given to it in Clause 16.6.3;

       "Affected Interest Period" has the meaning given to it in Clause 8.5.1;

       "Affected Lender" has the meaning given to it in Clause 10.1.1;

       "Agency Indemnitees" has the meaning given to it in Clause 16.8.1;

       "Agent" means Bankers Trust Company acting in its capacity as agent for
       the Lenders or such other agent for the Lenders as shall be appointed
       pursuant to Clause 16.9;

       "Annan Facility" means the manufacturing facility situated at Annan,
       Dumfries, Scotland to be purchased pursuant to the Sale and Purchase
       Agreement;

       "Annan Note" means the note dated the date hereof to be issued by ChiRex
       (Annan) Limited to the Borrower in respect of the proceeds of the Tranche
       A Facility;

       "Approved Accounting Principles" means (a) with regard to the Borrower,
       ChiRex (Dudley) Limited, and ChiRex (Annan) Limited, accounting
       principles and practices generally accepted in the U.K. consistently
       applied and (b) with regard to ChiRex Inc. and ChiRex America Inc.,
       accounting principles generally accepted in the U.S. consistently
       applied;


                                        4
                                                                   Executed Copy
<PAGE>   6

       "Assets" has the meaning set forth in the Sale and Purchase Agreement;

       "Auditors" means Arthur Andersen, or such other firm of accountants as
       the Borrower may appoint in compliance with the provisions of Clause
       13.3.3;

       "Availability Period" means the period commencing on the Initial Drawdown
       Date and ending on the earlier of (i) the fifth day thereafter and (ii)
       the date on which the Commitments are terminated in full;

       "Available Amount" means, at any time, the lesser of (i) 50% of the
       cumulative Net Income of the ChiRex Group or (ii) 50% of the cumulative
       Cashflow of the ChiRex Group, in each case calculated for each successive
       Accounting Reference Period or part thereof beginning on the date of this
       Agreement and ending on the last day of the Accounting Reference Period
       ending immediately prior to such time, and in each case after making
       appropriate deduction in respect of any Accounting Reference Period in
       which Net Income or Cashflow, as the case may be, is negative;

       "Available Currency" means (a) in respect of the Tranche A Facility, GBP
       only and (b) in respect of the Tranche B Facility, DEM, FF, LIT, GBP,
       CHF, Yen and USD and, subject to the provisions of Clause 5.1.7, any
       other currency freely available to all the Lenders in which dealings
       regularly occur in the London interbank market, provided that the Agent
       has, prior to selection of such currency, confirmed such availability to
       the Borrower;

       "Borrower" means ChiRex (Holdings) Limited;

       "Business" means the business of ChiRex Inc. and its subsidiaries as
       described in ChiRex Inc.'s Form 10-K with respect to its fiscal year most
       recently ended;

       "Business Day" means, in respect of each Available Currency, a day (other
       than a Saturday, Sunday or public holiday) which is a day on which banks
       are open for dealings in such Available Currency in the London interbank
       market and on which banks are open for business (and are not permitted by
       law to remain closed) in the place where the main domestic market for
       such Available Currency is situated;

       "Business Plan" means a set of five year financial projections, together
       with the assumptions forming the


                                        5
                                                                   Executed Copy
<PAGE>   7

       basis thereof, prepared in connection with the execution and delivery of
       this Agreement by the management of ChiRex Inc. in respect of the
       consolidated operations of ChiRex Inc. and its subsidiaries, which
       Business Plan shall include the initial Operating Budget;

       "Capital Expenditure" means in relation to a person or group of persons,
       expenditure treated as expenditure in respect of tangible fixed assets in
       accordance with the applicable Approved Accounting Principles and
       determined for such person or, on a consolidated basis, for such persons
       (as the case may be);

       "Cashflow" means, in respect of the relevant testing period in relation
       to a person or group of persons under the applicable Approved Accounting
       Principles:

       EBITDA, adjusted as follows, to the extent not already similarly treated
       in calculating EBITDA,

            PLUS: (a)   decreases in Working Capital during the relevant period,
                        and losses on fixed asset disposals during the relevant 
                        period;

                  (b)   increases in provisions to the extent not previously
                        taken into account in Working Capital (other than
                        deferred tax provisions);

                  (c)   cash proceeds from the issuance of shares of capital
                        stock in ChiRex Inc. and cash proceeds from any Equity
                        Sale;

                  (d)   cash income constituting extraordinary or exceptional
                        items; and

                  (e)   Net Cash Proceeds of disposals during the relevant
                        period, if positive;

           MINUS: (f)   increases in Working Capital during the relevant period
                        and gains on fixed asset disposals during the relevant
                        period;

                  (g)   Capital Expenditure paid during the relevant period
                        which expenditure is (i) in accordance with the Business
                        Plan, or (ii) pursuant to the prior written consent of
                        the Agent;

                  (h)   Tax paid during the relevant period;


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                  (i)   Total Debt Service, to the extent paid in cash, in
                        respect of (i) Financial Indebtedness under the Finance
                        Documents, (ii) Continuing Indebtedness, and (iii)
                        Permitted Indebtedness falling within paragraph (iii) or
                        (x) of the definition thereof;

                  (j)   the sum of prepayments pursuant to Clauses 7.1 (to the
                        extent applied pursuant to the provisions hereof to
                        Tranche A Term Advances only) and 7.3;

                  (k)   cash expenses constituting extraordinary or exceptional
                        items;

                  (l)   decreases in provisions to the extent not previously
                        taken into account in Working Capital (other than
                        deferred tax provisions); and

                  (m)   Net Cash Proceeds of disposals during the relevant
                        period, if negative;

       and determined in accordance with such Approved Accounting Principles for
       such person or, on a consolidated basis, for such persons (as the case
       may be);

       "Change of Control" means (i) ChiRex Inc. shall cease to beneficially own
       and control, directly or indirectly, 100% of the issued and outstanding
       shares of ChiRex America Inc. or the Borrower, or the greater of (A) 75%
       of the issued and outstanding shares of capital stock of any of its other
       subsidiaries or (B) the percentage of ownership necessary for ChiRex Inc.
       to maintain group tax benefits with respect to its other subsidiaries; or
       (ii) any person or any two or more persons acting in concert shall have
       acquired beneficial ownership (within the meaning of Rule 13d-3 under the
       Exchange Act), directly or indirectly, of the equity securities of ChiRex
       Inc. (or other securities convertible into such equity securities)
       representing 50% or more of the combined voting power of all equity
       securities of ChiRex Inc. entitled to vote in the election of director;
       or (iii) any person or any two or more persons acting in concert shall
       have acquired the ability to exercise management control over ChiRex
       Inc.;

       "CHF" means the lawful currency from time to time of Switzerland;


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       "ChiRex (Annan) Limited" means ChiRex (Annan) Limited, a limited company
       organised under the laws of England with registered number 3417229;

       "ChiRex Group" means ChiRex Inc. and each direct and indirect subsidiary
       thereof;

       "ChiRex Inc." means ChiRex Inc., a corporation organised under the laws
       of the state of Delaware;

       "Code" means the United States Internal Revenue Code of 1986;

       "Commitment" means, in relation to the participation of any Lender in a
       Facility, the amount stated opposite its name in Schedule 1 in relation
       to that Facility (or, in the case of a Transferee, the amount stated in
       the Schedule to the relevant Transfer Certificate as being transferred to
       that Transferee), in each case as the same may be transferred (in whole
       or in part), cancelled, reduced, varied or terminated in accordance with
       the terms of this Agreement;

       "Continuing Indebtedness" means financial indebtedness of the ChiRex
       Group identified on Schedule 8, and in each case all interest and other
       amounts accrued thereon during or for the interest period current at any
       date of determination, each such item of financial indebtedness being
       evidenced by its related agreement, deed or other instrument in the form
       in existence on the date of this Agreement, subject to such changes
       therein and refinancings thereof as do not materially prejudice the
       interests of the Finance Parties under or in connection with the Finance
       Documents;

       "Dangerous Substance" means any natural or artificial substance (whether
       in a solid or liquid form or in the form of a gas or vapour and whether
       alone or in combination with any other substance) (i) capable of causing
       harm to man or any other living organism or of damaging the Environment
       or causing danger to public health or welfare, including without
       limitation any hazardous, toxic or dangerous waste, which is subject to
       regulation by any Governmental Authority under any applicable
       Environmental Law, or (ii) because of its quantity, concentration or
       physical or chemical characteristics, exposure to which is limited by any
       applicable Governmental Authority;


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       "Deed of Accession" means one or more deeds to be executed by any obligor
       who becomes an Obligor after the date of this Agreement, substantially in
       the form of Schedule 6, subject to variation in accordance with the laws
       of the jurisdiction of organisation of the relevant Obligor which relate
       to the giving of guarantees and similar undertakings, and with such
       amendments thereto as the Agent may reasonably require or permit;

       "Default Interest Period" has the meaning given to it in Clause 8.4.1.;

       "Default Rate" has the meaning given to it in Clause 8.4.1;

       "DEM" means the lawful currency from time to time of the Republic of
       Germany;

       "Discharged Rights and Obligations" has the meaning given to it in Clause
       25.3.2;

       "Drawdown" means the making of the Advances hereunder;

       "Drawdown Date" means the date for the making of an Advance as specified
       by the Borrower in the relevant Drawdown Request;

       "Drawdown Request" means a notice requesting an Advance in the form set
       out in Schedule 3;

       "Dudley Facility" means the manufacturing facility situated at Dudley,
       Cramlington, Northumberland NE23 7QG, England, owned as of the date of
       this Agreement by ChiRex (Dudley) Limited;

       "Due Diligence Report (Legal)" means, collectively, (i) ChiRex Inc.'s
       Form 10-K with respect to its fiscal year ended 31st December 1996, (ii)
       the report(s) in agreed terms previously compiled by Dibb Lupton Alsop
       regarding the Annan Facility, (iii) the report(s) in agreed terms
       compiled by Brodies WS regarding the Annan Facility, (iv) the report(s)
       in agreed terms compiled by British Geological Survey regarding the water
       supply at the Annan Facility, and (v) the report(s) in agreed terms
       compiled by MacFarlanes regarding the Dudley Facility;

       "EBIT" means, in respect of the relevant testing period and in relation
       to a person or group of persons under the applicable Approved Accounting
       Principles, EBITDA less (i) depreciation on all fixed assets, (ii)
       amortisation


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       of goodwill, acquisition costs and other intangible assets and (iii)
       write-downs, write-offs, minority interests and other non-cash charges in
       determining earnings of such person or persons for that period,
       determined in accordance with such Approved Accounting Principles for
       such person or, on a consolidated basis, for such persons;

       "EBITDA" means, in respect of the relevant testing period and in relation
       to a person or group of persons under the applicable Approved Accounting
       Principles, Net Income for that period, determined in accordance with
       such Approved Accounting Principles for such person or, on a consolidated
       basis, for such persons adding back (if previously deducted) or, as the
       case may be, before any deduction (to the extent that such deduction is
       made in the calculation of earnings) for or on account of:-

       (a)    Total Interest;

       (b)    Tax charged or credited during the relevant testing period;

       (c)    depreciation on fixed assets;

       (d)    amortisation of goodwill, acquisition costs and other intangible
              assets; and

       (e)    write-downs, write-offs, minority interests and other non-cash
              charges in determining earnings of such person or persons for that
              period;

       and excluding the effect, positive or negative, of items which would be
       regarded as extraordinary or exceptional items;

       "Employee Benefit Plan" means, at any time, any "employee benefit plan"
       as defined in Section 3(3) of ERISA and any "multiemployer plan" as
       defined in Section 3(37) of ERISA, to which any US Obligor or any of
       their respective ERISA Affiliates is contributing, or ever has
       contributed, or to which any US Obligor or any of their respective ERISA
       Affiliates has, or ever has had, an obligation to contribute;

       "Environment" consists of all, or any, of the following media: the air,
       water as ground water, surface water, drinking water supplied, vapour and
       ice, and land (both surface and subsurface); and the medium of the air
       includes the air within buildings and air within other


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       natural or manmade structures, above or below ground and "Environmental"
       shall be construed accordingly;

       "Environmental Claim" means (i) any threatened or instituted claim,
       demand, accusation, allegation or notice of violation, in each case made
       in writing, against any Obligor or any of their respective subsidiaries
       (not being a purely vexatious, frivolous or specious claim) by any person
       (x) in respect of any loss or liability suffered or incurred by that
       person as a result or in connection with any violation of Environmental
       Law or (y) giving rise to any remedy or penalty that may be enforced or
       assessed by private or public legal action in connection with
       Environmental Contamination or (ii) any remedial action or action to
       comply that any Obligor or any of their respective subsidiaries is
       obliged to undertake pursuant to Environmental Law in connection with
       Environmental Contamination, or (iii) any application for any interim or
       final judicial or administrative decree, injunction, cease and desist
       order, abatement order, compliance order, consent order, consent decree,
       settlement agreement, request for information, clean-up order or
       enforcement notice, stop notice, improvement notice, prohibition notice
       or revocation order against any Obligor or any of their respective
       subsidiaries in respect of Environmental Contamination;

       "Environmental Contamination" means the following and the consequences
       resulting therefrom: any condition connected with any emission, release,
       leakage, spillage, or presence, use, leaching or migration (in any case
       whenever occurring), of Dangerous Substances at or from any site (or the
       migration of a Dangerous Substance from surrounding property or
       groundwater in, into or onto any site) owned or operated by any Obligor
       or any of their respective subsidiaries, and any residual Dangerous
       Substance on or under any site owned or operated by any Obligor or any of
       their respective subsidiaries including (without limitation) the storage,
       keeping, handling, labeling, transfer or disposal of Dangerous
       Substances, to the extent any of the foregoing results in a breach of any
       Environmental Law or has given or could reasonably be expected to give
       rise to an Environmental Claim;

       "Environmental Event" means any event (whenever occurring) which
       constitutes a breach of any Environmental Law or which has given or could
       reasonably be expected to give rise to an Environmental Claim;


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       "Environmental Law" means all present and future laws, regulations,
       ordinances, permits guidance documents or other requirements having legal
       effect in any jurisdiction in which any Obligor carries on business or
       owns assets, or in the European Union as a whole, concerning the
       protection of the Environment, human health and safety or the control of
       Dangerous Substances;

       "Environmental License" means any permit, license, authorisation, plan,
       consent order or consent decree of or from any Governmental Authority;

       "Environmental Report" means such reports or other documents from the
       Obligors and/or third parties in form and substance satisfactory to the
       Agent to be provided to the Agent in connection with the execution and
       delivery of the Agreement, compiling information relating to compliance
       by the Obligors with, and liabilities of the Obligors under, applicable
       Environmental Laws, including the following documents: (i) Environmental
       Phase I Survey of Annan Facility, dated September 1997, prepared by Dames
       & Moore, (ii) Environmental Phase I Survey of Dudley Facility, dated
       August 1995, prepared by Peter Brett Associates, (iii) Environmental
       Phase I Update of Dudley Facility, dated November 1995, prepared by
       Environmental Resources Management, and (iv) management letter dated 30th
       October, 1997, relating to environmental updates in respect of the Dudley
       Facility;

       "Equity Sale" means the sale or transfer of equity securities in any
       direct or indirect subsidiary of ChiRex Inc., which sale or transfer
       dilutes the aggregate percentage equity ownership (direct or indirect) of
       ChiRex Inc. in such subsidiary;

       "Equivalent Amount" means the amount of a currency other than GBP that
       can be purchased with GBP calculated on the basis of the Agent's spot
       rate of exchange for the purchase of such other currency with GBP on the
       date such calculation is to be made (such calculation to be made, for the
       purpose of determining the amount available to be drawn under the Tranche
       B Multicurrency Revolving Facility, on the Rate Fixing Day applicable to
       the relevant Drawdown Date);

       "ERISA" means the Employee Retirement Income Security Act of 1974, as
       amended from time to time, and any successor statute;


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       "ERISA Affiliate", as applied to any person, means any entity required to
       be treated with any US Obligor as a single employer under Section 414 of
       the Internal Revenue Code;

       "Event of Default" means one of the events specified in Clause 14.1;

       "Exchange Act" means the Securities Exchange Act of 1934, as amended from
       time to time, and any successor statute;

       "Facilities" means the Tranche A Facility and the Tranche B Facility
       (including the WCP Facilities) not in excess of the Total Commitments
       granted to the Borrower hereunder (as the same may be reduced in
       accordance with the terms of this Agreement);

       "Facility Amount" means (i) in the case of the Tranche A Term Facility,
       GBP 40,000,000, and (ii) in the case of the Tranche B Multicurrency
       Revolving Facility, GBP 22,000,000, or the Equivalent Amount thereof, in
       each case as the same may be reduced or cancelled pursuant to the terms
       of this Agreement;

       "Fees Letter" means the letters from ChiRex Inc. to Bankers Trust
       International PLC in the agreed terms setting out details of the fees
       payable pursuant to Clause 11.1.1(b);

       "FF" means the lawful currency from time to time of the Republic of
       France;

       "Final Repayment Date" means the earlier of (a) 31st December, 2002 and
       (b) the date on which the Commitments are terminated in full in
       accordance with the terms of this Agreement;

       "Finance Documents" means this Agreement, the Fees Letter, each WCP
       Agreement, each Transfer Certificate, each Security Document, each Deed
       of Accession and any other document expressed to be made supplemental to,
       amending and/or modifying any of the foregoing or entered into pursuant
       hereto or thereto, and "Finance Document" means any of them;

       "Finance Indemnitees" has the meaning given to it in Clause 27.1;

       "Finance Parties" means each Arranger, the Agent, the Security Agent,
       each Lender and each WCP Provider, and

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       "Finance Party" means any of them; "Financial Indebtedness" means,
       without duplication, any indebtedness in respect of or arising under or
       in connection with:-

       (i)    moneys borrowed including, without limitation, on a contractually
              subordinated basis;

       (ii)   any debenture, bond, note or loan stock or other similar
              instrument;

       (iii)  any acceptance or documentary credit (except, in the case of
              documentary credits, those issued in support only of liabilities
              to trade creditors incurred in the ordinary course of business and
              having a term of not more than 90 days);

       (iv)   receivables sold or discounted in a transaction other than one in
              respect of which (a) no recourse exists against any Obligor and no
              Obligor has any obligation to repurchase, or make any payment in
              respect of deficiencies in collection of, any receivables, and (b)
              no Obligor has the right or obligation to sell, discount or
              otherwise dispose of receivables in addition to those transferred
              on the initial funding date of the transaction;

       (v)    the acquisition cost of any asset to the extent payable after the
              time of acquisition or possession by the person liable as
              principal obligor for the payment thereof where the deferred
              payment is arranged primarily as a method of raising finance or
              financing or refinancing the acquisition of the asset acquired
              (which, for the avoidance of doubt, shall not include liabilities
              to trade creditors incurred in the ordinary course of business and
              having a term of not more than 90 days);

       (vi)   the sale price of any asset to the extent paid before the time of
              sale or delivery by the person liable to effect such sale or
              delivery where the advance payment is arranged primarily as a
              method of raising finance or financing or refinancing the
              manufacture, assembly, acquisition or holding of the asset to be
              sold;

       (vii)  finance leases, credit sale or conditional sale agreements
              (whether in respect of land, buildings, plant, machinery,
              equipment or otherwise) entered into primarily as a method of
              raising finance or financing or refinancing


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              the acquisition of the relevant asset (but not including
              liabilities under operating leases);

       (viii) the amount payable under any put option or other arrangement
              whereby the Borrower or any of its subsidiaries is liable to
              purchase share capital or other securities issued;

       (ix)   any guarantee, indemnity or similar assurance against financial
              loss of any person in respect of obligations of the type described
              in the preceding paragraphs (i) to (viii);

       (x)    any guarantee, endorsement or other undertaking of responsibility
              for any obligations of any other person, whether (a) directly or
              indirectly by agreement to purchase the Financial Indebtedness of
              any other person, or (b) through the purchase of goods or other
              assets, supplies or services, or maintenance of working capital or
              other balance sheet covenants or conditions, or by way of stock
              purchase, capital contribution, advance or loan which, in any case
              in this subclause (b), is entered into for the purpose of paying
              or discharging any Financial Indebtedness of such other person or
              assuring the holder of such Financial Indebtedness or obligation
              against loss in respect thereof;

       (xi)   amounts raised under any other transaction having as a primary,
              and not an incidental effect, the commercial effect of a
              borrowing;

       (xii)  debts incurred in the ordinary course of business which remain
              unpaid for more than 60 days after their due date for payment,
              including for this purpose debts which upon their incurrence are
              within the exceptions set forth in paragraph (iii) above (other
              than debts which are being diligently contested in good faith
              unless the Agent reasonably believes that there is no reasonable
              prospect of success); or

       (xiii) net amounts payable under any interest rate or currency swap,
              collar or other similar agreement or any other hedging or
              derivative instrument, the amount of Financial Indebtedness being
              attributable thereto being 10% of the face or notional amount of
              the relevant agreement, or in each case such lower


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              percentage as shall be reasonably approved by the Agent;

       "GBP" means the lawful currency from time to time of the United Kingdom;

       "Glaxo Group Limited" means Glaxo Group Limited, a company organised
       under the laws of England, whose registered office is at Glaxo Wellcome
       House, Berkeley Avenue, Greenford, Middlesex UB6 0NN;

       "Glaxo Operations UK Limited" means Glaxo Operations UK Limited, a
       company organised under the laws of England, whose registered office is
       at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN;

       "Governmental Authority" means any domestic or foreign court or
       governmental body, department, agency, commission, authority or
       instrumentality;

       "Guarantees" means the guarantees by the Guarantors pursuant to Clause
       15;

       "Guarantor" means, together, ChiRex Inc., ChiRex (Dudley) Limited, ChiRex
       (Annan) Limited, and/or other guarantors acceptable to the Lenders;

       "Holdings Note" means the promissory note issued by the Borrower to
       ChiRex Inc. on 30th October 1997 in the principal amount of USD
       38,234,000;

       "ICTA" means the Income and Corporation Taxes Act 1988, as the same may
       be amended from time to time;

       "Industry Report" means the report by Chem. Systems, together with the
       letter in respect thereof, each addressed to and for the benefit of,
       inter alia, the Finance Parties;

       "Information Memorandum" means the document containing information
       relating to the Business prepared in connection with this Agreement by
       the Agent and the ChiRex Group and distributed by the Agent to the
       Lenders and potential Lenders;

       "Initial Drawdown" means the making of the first Advance hereunder, which
       Advance must in any event be an amount sufficient to discharge all fees
       due and payable on the Initial Drawdown Date pursuant to Clause 11.1.1;


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       "Initial Drawdown Date" means the date of the Initial Drawdown, which
       date shall occur on or after each of the conditions set forth in Clause
       4.1 have been satisfied or waived by the Agent, and which date shall
       occur on or before the tenth Business Day after the date of this
       Agreement;

       "Intellectual Property" means all patents and patent applications, trade
       and/or service marks and trade and/or service mark applications (and all
       goodwill associated with such applications), all brand and trade names,
       all copyrights and rights in the nature of copyright, all design rights,
       all registered designs and applications for registered designs, all trade
       secrets, know-how and all other intellectual property rights now or in
       the future owned by any Obligor throughout the world or the interest of
       any Obligor in any of the foregoing now or in the future, together with
       the benefit of all present and future agreements entered into or the
       benefit of which is enjoyed by any Obligor relating to the use or
       exploitation of any of the aforementioned rights;

       "Interest Coverage Ratio" means, at any time, the ratio of (i)
       consolidated EBITDA for the immediately preceding four Accounting
       Quarters, to (ii) Total Interest for the immediately preceding four
       Accounting Quarters, in each case in respect of the ChiRex Group.;

       "Interest Payment Date" means, in relation to an Advance, the date
       determined pursuant to Clause 8.2;

       "Interest Period" means a period by reference to which interest is
       calculated and payable on an Advance or an overdue sum, and includes a
       Default Interest Period;

       "Internal Revenue Code" means the Internal Revenue Code of 1986, as
       amended to the date hereof and from time to time hereafter;

       "Lender" and "Lenders" means the persons identified as "Lenders" and
       listed on the signature pages of this Agreement, or, as the case may be,
       an assignee or Transferee therefrom to whom rights and/or obligations are
       assigned or transferred in accordance with Clause 25.2 or 25.3, and
       includes a successor of any such person;

       "Lending Office" means in relation to a Lender, the office or offices
       through which it is acting for


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       the purpose of this Agreement, which office or offices initially are set
       out in Schedule 1;

       "LIBOR" means, in relation to any Advance or any overdue sum:-

       (a)    the rate determined by the Agent to be the arithmetic mean
              (rounded upwards, if necessary, to the nearest five decimal
              places) of the offered quotations for deposits in the relevant
              Available Currency for a period equal to the Interest Period
              relating to that Advance (or overdue sum) which appear on the
              Telerate Display Screen page number 3750 (or such other page(s) as
              may replace such pages from time to time on that system) at or
              about 11.00 a.m. (London time) on the relevant Rate Fixing Day; or

       (b)    if no such offered quotations appear on the relevant page as
              aforesaid the arithmetic mean (rounded upwards, if necessary, to
              the nearest five decimal places) of the respective rates, as
              supplied to the Agent at its request, quoted (subject to Clause
              8.1.3) by the Reference Lenders to prime lenders in the London
              Interbank Market at or about 11.00 a.m. (London time) on the
              relevant Rate Fixing Day for the offering of deposits in the
              relevant Available Currency and in an amount comparable to the
              amount of, and for a period equal to the Interest Period relating
              to, that Advance (or overdue sum) for delivery on the first day of
              that Interest Period;

       "LIT" means the lawful currency from time to time of Italy;

       "Loan" means the aggregate principal amount of all Advances for the time
       being outstanding under this Agreement, and "Tranche A Term Loan" and
       "Tranche B Multicurrency Revolving Loan" shall be construed accordingly;

       "Majority Lenders" means one or more Lenders, the sum of whose Relevant
       Amounts equals or exceeds 51 per cent. (51%) of the aggregate of the
       Relevant Amounts of all the Lenders;

       "Mandatory Liquid Asset Costs" means, in relation to each Lender, the
       additional cost to such Lender of complying with (i) the relative reserve
       asset ratio required by the Bank of England from time to time (if any),
       expressed as


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       a percentage per annum and calculated as set forth in Schedule 5, or (ii)
       any analogous requirement of any central banking or financial regulatory
       authority imposed at the date of this Agreement in respect of the funding
       or maintenance of commitments or loans of the type contemplated hereby
       and applicable to a specific currency;

       "Margin" means 1.00% for the period commencing on the Initial Drawdown
       Date and ending on the last day of the fourth full Accounting Quarter
       following such date, and thereafter 0.75%, upon ChiRex Inc. (on a
       consolidated basis) achieving a level of Total Debt/EBITDA Ratio equal to
       1.5 : 1 (and only for such time as such level continues to be achieved),
       tested as at the last day of the immediately preceding Accounting Quarter
       and calculated as provided in Clause 13.4 provided that:-

       (a)    there shall be no decrease in the Margin if there has occurred an
              Event of Default or a Potential Event of Default which is
              continuing and the Margin shall remain at or increase to 1.00%
              until such time as such Event of Default or Potential Event of
              Default is no longer continuing, whereupon the Margin shall be
              determined as aforesaid; and

       (b)    any reduction or increase in the Margin shall take effect as from
              the date of receipt by the Agent of the relevant accounts in
              accordance with Clause 13.3.4 (on the basis that in the case of a
              reduction or increase taking effect during an Interest Period the
              interest payable on the Interest Payment Date will reflect such
              reduction or increase on a time apportioned basis);

       "Margin Stock" means margin stock within the meaning of Regulations G, T,
       U and X of the Board of Governors of the Federal Reserve System of the
       U.S.;

       "Material Adverse Effect" has the meaning given thereto in Clause 1.2.5;

       "Material Agreement" means, at any time, any agreement or group of
       related agreements (i) to which, individually or in the aggregate, is
       attributable (on a reasonable estimation basis) 10% or more of either the
       gross turnover or the EBITDA of the ChiRex Group for the Accounting
       Reference Period then in effect, or, at any time before 31st December,
       1997, for the Accounting Reference Period ending on 31st December, 1998,
       or (ii)


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       the termination or non-performance of which would constitute a Material
       Adverse Effect;

       "Material Subsidiary" means any direct or indirect subsidiary of ChiRex
       Inc. other than a subsidiary that has been designated in writing by the
       Agent as a Non-Material Subsidiary; provided that upon each such
       designation, ChiRex Inc. shall deliver a certificate signed on behalf of
       ChiRex Inc. by two of its officers, certifying that (i) the aggregate
       gross turnover of the Non-Material Subsidiaries as at such date does not
       exceed 10% of the gross turnover of ChiRex Inc. and its subsidiaries as
       at such date, (ii) the aggregate gross assets of the Non-Material
       Subsidiaries as at such date does not exceed 10% of the gross assets of
       ChiRex Inc. and its subsidiaries as at such date, and (iii) the aggregate
       EBITDA of the Non-Material Subsidiaries as at such date does not exceed
       10% of the EBITDA of ChiRex Inc. and its subsidiaries as at such date.
       For this purpose:-

       (a)    in the case of a person which itself has subsidiaries, the
              calculation shall be made by using the consolidated gross turnover
              or gross assets or EBITDA of it and its subsidiaries; and

       (b)    the calculation of consolidated gross turnover or gross assets or
              EBITDA shall be made by reference to:-

(i)    the accounts of the relevant subsidiary (or, as the case may be, a
       consolidation of the accounts of it and its subsidiaries) used for the
       purpose of the then latest unaudited quarterly or audited annual
       consolidated accounts of ChiRex Inc. delivered to the Agent under Clause
       4.1.1 or 13.3 (as the case may be) or, in the case of a newly acquired or
       formed subsidiary, the most recent unaudited quarterly or audited annual
       accounts of the relevant subsidiary (or, as the case may be, a
       consolidation of the accounts of it and its subsidiaries), provided such
       accounts report a period ending no earlier than six months from the date
       of such calculation; and

(ii)   the unaudited quarterly or audited annual consolidated accounts (as the
       case may be) of ChiRex Inc. on a pro forma basis together with any
       newly-acquired or formed subsidiary described in sub-clause (b)(i) of
       this definition;


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       "Multiborrower Revolving Note" means the note(s) dated the date hereof to
       be issued by each member of the ChiRex Group (other than the Borrower) to
       the Borrower in respect of the proceeds of the Tranche B Facility;

       "Net Cash Proceeds" means the remainder of cash proceeds arising from the
       disposal of any fixed asset or any part of the business of any Obligor,
       or from any Equity Sale, after deducting (i) in the case of such a
       disposal, required repayment of Financial Indebtedness secured by such
       asset and/or Financial Indebtedness incurred to purchase such asset or
       business (or any refinancings thereof), (ii) reasonable costs related to
       such Equity Sale or disposal, and (iii) reasonable provision for Taxes
       attributable to such Equity Sale or disposal;

       "Net Income" means, in respect of any period and in relation to:

       (a)    the Borrower, the profit shown on the Borrower's profit and loss
              account for such period, determined in accordance with Approved
              Accounting Principles; or

       (b)    the ChiRex Group, the profit shown on the profit and loss account
              on a consolidated basis for the ChiRex Group for such period,
              determined in accordance with the applicable Approved Accounting
              Principles, provided that there shall be excluded (i) the profit
              of any person (other than any Obligor) in which any other person
              (other than any Obligor or any of their respective subsidiaries)
              has a joint interest, except to the extent of the amount of
              dividends or other distributions actually paid to any Obligor or
              any of their respective subsidiaries by such person during such
              period and (ii) the profit of any person accrued prior to the date
              it becomes a subsidiary of any Obligor or any of their respective
              subsidiaries or is merged into or consolidated with any Obligor or
              any of their respective subsidiaries or that person's assets are
              acquired by any Obligor or any of their respective subsidiaries;

       "Net Tranche B Multicurrency Revolving Commitment" means, in relation to
       any Lender, its Tranche B Multicurrency Revolving Commitment less, to the
       extent it is a WCP Provider under the Tranche B Facility, the amount of
       its WCP Commitment under the Tranche B Facility pursuant to Clause 3.6.1
       from time to time;


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       "Non-Material Subsidiary" means a subsidiary of ChiRex Inc. that is not a
       Material Subsidiary;

       "Obligor" means the Borrower, each Guarantor and any other member of the
       ChiRex Group which is or becomes a party to a Finance Document;

       "Operating Budget" means a budget for the ChiRex Group in form and scope
       reasonably satisfactory to the Agent and consistent with the financial
       reporting of the ChiRex Group (including budgeted statement of income,
       and sources and uses of cash and balance sheets);

       "Participation" means, in relation to a Lender and a Facility, its right,
       title, interest and obligations in relation to such Facility, namely:-

       (a)    its right to receive its Participation Proportion of principal and
              interest in respect of outstanding Advances under the Facility
              including its right to any consequential payment pursuant to
              Clause 3.7.1; and

       (b)    its obligation to participate in its Participation Proportion in
              future Advances up to the limit of that Facility;

       "Participation Proportion" means, in relation to a Lender and a Facility,
       the proportion in which that Lender has agreed to participate in that
       Facility pursuant to Clause 3.1 (Basis of Participation) and subject to
       Clause 3.6 (the WCP Facilities);

       "PBGC" means the Pension Benefit Guaranty Corporation (or any successor
       thereto);

       "Permitted Indebtedness" means, in relation to the Obligors:-

       (i)    Financial Indebtedness outstanding under any of the Facilities;

       (ii)   the Continuing Indebtedness (and refinancings thereof), provided
              that the principal amount thereof shall not be increased after the
              date of this Agreement;

       (iii)  finance leases, hire purchase and conditional sale agreements in
              relation to which the maximum aggregate liability on termination
              of


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              such leases or agreements would not exceed in aggregate GBP
              1,000,000 (or its equivalent);

       (iv)   guarantees, indemnities or bonds given in the ordinary course of
              trading activities;

       (v)    Financial Indebtedness arising from a loan or credit permitted by
              Clause 13.2.12;

       (vi)   Financial Indebtedness (and any refinancings thereof) of any
              person which, by way of acquisition after the date of this
              Agreement, will be consolidated on the ChiRex Group's financial
              statements, provided that: (i) such Financial Indebtedness was
              subsisting prior to the date of the person's acquisition, (ii)
              such Financial Indebtedness was not incurred in contemplation of
              or in connection with the acquisition, (iii) the principal amount
              of such Financial Indebtedness shall not have been and shall not
              be increased after the date of such acquisition above the amount
              outstanding on such date or, if greater, the maximum amount
              available to be drawn under the documentation governing such
              Financial Indebtedness as in effect on such date, and (iv) the
              aggregate amount of such Financial Indebtedness outstanding at any
              one time, when added to that outstanding and permitted pursuant to
              item (x) of this definition, shall not exceed GBP 10,000,000 (or
              its equivalent);

       (vii)  Financial Indebtedness in connection with the provision of customs
              bonds required in the ordinary course of trading of the relevant
              person;

       (viii) Permitted Subordinated Debt;

       (ix)   guarantees, indemnities or similar assurances given by an Obligor
              in respect of obligations of another member of the ChiRex Group
              which is a Tier I Guarantor, the guaranteed obligations in each
              case in this paragraph (ix) being themselves permitted under this
              Agreement;

       (x)    Financial Indebtedness not falling within any other paragraph of
              this definition in a principal amount which when added to
              Financial Indebtedness outstanding and permitted pursuant to item
              (vi) of this definition, does not exceed GBP 10,000,000 (or its
              equivalent) at any one time outstanding; and


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       (xi)   any other Financial Indebtedness incurred with the consent of the
              Agent (acting on the instructions of the Majority Lenders);

       "Permitted Investment" means, in relation to the Obligors:-

       (i)    cash;

       (ii)   commercial paper maturing not more than nine months from the date
              of issue and rated at least A-1 by Standard & Poor's Ratings Group
              or P-1 by Moody's Investors Service, Inc.;

       (iii)  any deposit of not more than one year's maturity with, or
              acceptance maturing not more than one year after issue accepted
              by, a bank or credit institution which has a combined capital and
              surplus and undistributable profits of not less than GBP
              100,000,000 (or its equivalent) and whose short term unsecured,
              unsubordinated debt rating is at least A-1 by Standard & Poor's
              Ratings Group or P-1 by Moody's Investors Service, Inc.;

       (iv)   securities issued or directly and fully guaranteed or insured by
              the governments of Great Britain or the United States of America
              or any agency or instrumentality thereof having maturities of not
              more than one year from the date of acquisition;

       (v)    repurchase obligations with a term of not more than seven days
              fully collateralised by underlying securities of the types
              described in paragraphs (ii) and (iii) above entered into with any
              bank meeting the qualifications specified in paragraph (iii)
              above;

       (vi)   debt securities having not more than one year until final maturity
              and listed on a recognised stock exchange and rated at least Aa by
              Moody's Investors Service, Inc. or AA by Standard & Poor's Ratings
              Group;

       (vii)  loans or credits permitted pursuant to Clause 13.2.12;

       (viii) investments in the ordinary course of the trading business of the
              relevant person; and


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       (ix)   investments in subsidiaries in the respective amounts in effect on
              the date of this Agreement;

       "Permitted Security Interest" means, in relation to the Obligors:-

       (i)    Security Interests granted with the consent of the Agent (acting
              on the instructions of the Majority Lenders);

       (ii)   liens arising and subsisting by operation of law and in the
              ordinary course of business activities;

       (iii)  rights of set-off existing in the ordinary course of trading
              activities between such Obligor and its suppliers or customers,
              and rights of set-off arising by operation of law by virtue of the
              provision to such person of bank clearing facilities or overdraft
              facilities permitted hereunder;

       (iv)   any retention of title to goods supplied to such Obligor where
              such retention is permitted by the relevant person in the ordinary
              course of its trading activities and on customary terms;

       (v)    Security Interests securing Financial Indebtedness referred to in
              paragraph (vi) of the definition of "Permitted Indebtedness",
              provided that: (i) such Security Interest was subsisting prior to
              the date of the person's acquisition by such Obligor, (ii) such
              Security Interest was not granted in contemplation of or in
              connection with the acquisition, and (iii) the principal Financial
              Indebtedness secured by any such Security Interest shall not be
              increased after the date of such acquisition;

       (vi)   Security Interests securing the Continuing Indebtedness on the
              date of this Agreement, provided that the principal Financial
              Indebtedness secured by any such Security Interest shall not be
              and shall not have been increased after such date;

       (vii)  Security Interests covering assets the subject of equipment and
              finance leases, hire purchase, conditional sale or similar
              arrangements entered into by such Obligor which are permitted by
              this Agreement;


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       (viii) Security Interests arising in respect of any escrow arrangements
              put into place for the purpose of a disposal or acquisition by
              such Obligor permitted by this Agreement; and

       (ix)   Security Interests of such Obligor not falling within any other
              paragraph of this definition securing Financial Indebtedness
              (including interest and fees relating thereto) which does not
              exceed GBP 100,000 (or its equivalent) at any one time;

       in each case, other than any of the aforementioned imposed pursuant to
       Section 401(1)(29) or 412(n) of the Internal Revenue Code or by ERISA;

       "Permitted Subordinated Debt" means unsecured Financial Indebtedness of
       the Obligors provided that either (i) such Financial Indebtedness is
       subordinated to the Financial Indebtedness outstanding under the Finance
       Documents upon terms in all respects reasonably satisfactory to the Agent
       taking into consideration the market in or into which it is issued, or
       (ii) the terms of subordination of such Financial Indebtedness provide,
       without limitation, that:

       (a)    such Financial Indebtedness shall not amortise prior to the final
              date of maturity, which date shall be no earlier than 31st
              December, 2003;

       (b)    no amount in respect of principal of such Financial Indebtedness
              (by way of purchase, redemption or otherwise) shall be paid until
              all amounts which may be or become payable under the Finance
              Documents have been irrevocably paid in full and all Commitments
              hereunder shall have terminated, except on terms and conditions
              reasonably satisfactory to the Majority Lenders and the Agent;

       (c)    no amount in respect of interest on such Financial Indebtedness
              may be paid until all amounts which may be or become payable under
              the Finance Documents have been irrevocably paid in full and all
              Commitments hereunder shall have terminated, except on terms and
              conditions reasonably satisfactory to the Majority Lenders and the
              Agent;

       (d)    no default in respect of such Financial Indebtedness shall arise
              and the lender thereof shall waive any available remedies as a
              result thereof until all amounts which may be or become payable
              under the


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              Finance Documents have been irrevocably paid in full and all
              Commitments hereunder shall have terminated;

       (e)    each lender in respect of such Financial Indebtedness shall agree
              that it will not accelerate any such Financial Indebtedness or
              otherwise declare it prematurely payable, enforce any such
              Financial Indebtedness (to the maximum extent permitted by law),
              petition for or otherwise take any steps with a view to any
              insolvency, liquidation, re-organization, administration or
              dissolution proceedings or any voluntary arrangement or assignment
              for the benefit of creditors or any similar proceedings, including
              without limitation any event referred to in Clause 14.1.5 to
              Clause 14.1.10 (inclusive) involving any member of the ChiRex
              Group or otherwise exercise any rights or pursue any remedy for
              the recovery of such Financial Indebtedness or in respect of any
              breach of covenant, misrepresentation or non-observance of any
              provision of such Financial Indebtedness, in each case, until all
              amounts which may be or become payable under the Finance Documents
              have been irrevocably paid in full and all Commitments hereunder
              shall have been terminated; and

       (f)    each lender in respect of such Financial Indebtedness shall agree
              to turn over to the Agent all payments and distributions received
              in respect of any proceeding referred to in Clause 14.1.5 to
              Clause 14.1.10 (inclusive) involving the Borrower, and any other
              amount paid in a manner inconsistent with clauses (a) and (b) of
              this definition, for application by the Agent to the satisfaction
              of outstandings under this Agreement until all amounts which may
              be or become payable under the Finance Documents have been
              irrevocably paid in full and all Commitments hereunder shall have
              been terminated;

       "Potential Event of Default" means any event which, with the giving of
       notice or the lapse of time or both or the making of any determination or
       the fulfilment of any condition, will constitute an Event of Default,
       provided that such notice, lapse of time, determination or condition is
       in any case specified or referred to in the relevant Event of Default as
       set forth in Clause 14.1;

       "Qualifying Lender" means an institution which is (i) a bank resident in
       the U.K. for the purpose of Section 349 of the Income and Corporation
       Taxes Act 1988 (as in effect on the date of this Agreement) and is
       beneficially


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       entitled to its Participation Proportion of interest due on the Advances
       or (ii) a bank lending through any other branch, affiliate or agency if
       the bank or affiliate (as the case may be) is resident in a country with
       which the United Kingdom has an appropriate double taxation treaty
       pursuant to which that bank or affiliate (as the case may be) is entitled
       to receive principal, interest and fees under this Agreement from the
       Borrower without withholding of United Kingdom income Tax or is otherwise
       entitled to receive principal, interest and fees without such
       withholding;

       "Rate Fixing Day" means, in relation to an Advance, the Business Day
       being two Business Days prior to the Drawdown Date for that Advance and,
       in relation to any Interest Period, the Business Day being two Business
       Days prior to the first day of that Interest Period provided that, in
       relation to an Advance denominated in GBP the Rate Fixing Day shall be
       the Drawdown Date or, as the case may be, the first day of the relevant
       Interest Period;

       "Recovering Lender" has the meaning given to it in Clause 19.1;

       "Recovery" has the meaning given to it in Clause 19.1;

       "Reference Lenders" means, subject to Clause 25.5.2, Bankers Trust
       Company and Midland Bank plc;

       "Relevant Amounts" means, in relation to a Lender, the aggregate from
       time to time of (a)(i) before the making of the initial Advances, its
       Commitments or (ii) after the making of the initial Advances, all
       Advances made by it then outstanding, or (b) if the Commitments have been
       terminated, all Advances made by it then outstanding;

       "Repayment Dates" means the semi-annual dates commencing on 31st
       December, 1998, as detailed in Schedule 2;

       "Repayment Schedule" means the repayment schedule for the Tranche A Term
       Facility which is set out in Schedule 2;

       "Reservations" means limitations on enforceability of legal documents
       dictated by local law and used as qualifications in legal opinions
       delivered to and accepted by the Agent in connection with the Initial
       Drawdown or the accession of a Guarantor pursuant to a Deed of Accession;


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       "Restricted Payment" means any of (i) the redemption, purchase,
       retirement or acquisition by ChiRex Inc. of any shares, warrants or other
       equity related securities issued by it, or the setting apart by it of any
       sum for such purpose, or other reduction by it of its capital, (ii) the
       declaration or payment by ChiRex Inc. or making of any other distribution
       on any ordinary or other shares issued by it, and (iii) before the
       Achievement Date only, the incurrence of any Capital Expenditure by the
       ChiRex Group in excess of that set forth for the relevant Accounting
       Reference Period in the Business Plan;

       "Revolving Lenders" means any Lender participating in the Tranche B
       Multicurrency Revolving Facility;

       "Sale and Purchase Agreement" means the Agreement in the agreed terms
       dated 23rd September 1997 between Glaxo Group Limited and ChiRex (Annan)
       Limited for the Sale and Purchase of the Business and Assets of Glaxo
       Group Limited operated from its site at Annan, Dumfries, Scotland;

       "Same Day Funds" means funds settled for value on the same day throughout
       a clearing system relevant for the currency concerned and such other
       funds as the Agent shall specify as being customary at the time for such
       settlement;

       "Scheme" means the ChiRex Pension Plan as established by an interim trust
       deed dated 5th February, 1996;

       "SEC" means the United States Securities and Exchange Commission (or any
       successor thereto);

       "Security Agent" means Bankers Trust Company as agent for the Finance
       Parties under the Security Documents or any other person as may from time
       to time hold the whole or any part of the security created thereby
       pursuant to Clause 16;

       "Security Documents" means each of:-

       (a)    Pledge Agreement dated as of the date hereof between the Security
              Agent, on behalf of the Lenders, and ChiRex Inc. relating to all
              the issued and outstanding shares of capital stock of ChiRex
              America Inc. and the Borrower, and the Holdings Note;


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       (b)    Debenture dated as of the date hereof between the Security Agent,
              on behalf of the Lenders, and the Borrower relating to all the
              issued and outstanding shares of ChiRex (Dudley) Limited and
              ChiRex (Annan) Limited, the Annan Note and the Multiborrower
              Revolving Notes;

       (c)    Debenture dated the date hereof by ChiRex (Dudley) Limited in
              favour of the Security Agent, on behalf of the Lenders, relating
              to the Dudley Facility and certain other assets of ChiRex (Dudley)
              Limited;

       (d)    Debenture dated the date hereof by ChiRex (Annan) Limited in
              favour of the Security Agent, on behalf of the Lenders, relating
              to certain assets of ChiRex (Annan) Limited; and

       (e)    Standard Security in agreed terms dated the date hereof by ChiRex
              (Annan) Limited in favour of the Security Agent, on behalf of the
              Lenders, relating to the Annan Facility;

       in each case as the same may be amended, from time to time, in accordance
       with its terms;

       "Security Interest" means any mortgage, charge (fixed or floating),
       standard security, pledge, lien, right of set-off hypothecation, trust,
       assignment by way of security, reservation of title, or any other
       security interest whatsoever, howsoever created or arising or any other
       agreement or arrangement (including, without limitation, a sale and
       repurchase arrangement) having the practical effect of conferring
       security, and any agreement to enter into, create or establish any of the
       foregoing;

       "Standard Security" means a standard security in terms of the
       Conveyancing and Feudal Reform (Scotland) Act 1970;

       "Syndication" has the meaning set forth in Clause 3.5;

       "Taxes" means and includes all present and future income and other taxes,
       levies, assessments, imposts, deductions, charges, duties, compulsory
       loans and withholdings whatsoever and wheresoever imposed and any charges
       in the nature of taxation together with interest thereon and penalties
       and fines with respect thereto, if any, and any payments made on or in
       respect thereof; and "Tax" and "Taxation" shall be construed accordingly;


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       "Tier I Guarantor" means any Guarantor which (i) has guaranteed all
       obligations of each Obligor hereunder and the amount of which guarantee
       is not subject to any limitation hereunder or under any Deed of
       Accession, if applicable, and (ii) for the purpose of securing such
       guarantee, has entered into one or more Security Documents in favour of
       the Security Agent creating in favour of the Security Agent a valid,
       perfected, first priority Security Interest in all or substantially all
       of such Guarantor's assets;

       "Total Borrowings" means, at any time, the aggregate outstanding amount
       of all Financial Indebtedness of all Obligors, calculated on a
       consolidated basis;

       "Total Commitments" means, together, the Lenders' Commitments.

       "Total Debt" means, as at any date of determination, in respect of any
       person or persons, the aggregate principal amount of Financial
       Indebtedness of such person or, on a consolidated basis, persons (as
       applicable), determined in accordance with the applicable Approved
       Accounting Principles;

       "Total Debt/EBITDA Ratio" means, at any time, the ratio of (i) Total Debt
       as of the last day of the immediately preceding Accounting Quarter, to
       (ii) consolidated EBITDA for the immediately preceding four Accounting
       Quarters, in each case in respect of ChiRex Inc.;

       "Total Debt Service" means, in respect of any period and any person or
       persons, the aggregate of (a) Total Interest and (b) the aggregate
       principal amount of Financial Indebtedness of such person or, on a
       consolidated basis, persons (as applicable) scheduled to be repaid
       (having regard to any reductions in respect thereof due to previous
       prepayment of any such amount where such prepayment occurred in a
       previous period) during such period under the terms and conditions
       relating to such Financial Indebtedness;

       "Total Interest" means, in respect of the relevant testing period, the
       aggregate of all interest (including amounts in the nature of interest in
       connection with any interest rate and/or currency swap, cap, floor,
       collar or other similar arrangement), guarantee fees, commitment fees and
       other costs and fees of a similar nature (not including, to the extent
       otherwise included, costs of issuance of debt, equity or warrants or
       amortisation of


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       debt discount) due in respect of Total Borrowings (including, for
       purposes of calculating "Total Borrowings" and notwithstanding sub-clause
       (xiii) of the definition of "Financial Indebtedness", 100% of the face or
       notional amount of each interest rate or currency swap, collar or other
       similar agreement or other hedging or derivative instrument as the
       Financial Indebtedness attributable thereto) and payable by the ChiRex
       Group during such period (including interest, the interest finance charge
       element of hire-purchase, credit sale and conditional sale agreements and
       of lease rentals under finance leases), less the sum of all interest
       (including amounts in the nature of interest in connection with any
       interest rate and/or currency swap, cap, floor, collar or other similar
       arrangement), guarantee fees, commitment fees and other costs and fees of
       a similar nature payable to the ChiRex Group during such period;

       "Tranche A Facility" or "Tranche A Term Facility" means the Tranche A
       Term loan facility not in excess of the Tranche A Term Commitments
       granted to the Borrower hereunder (as the same may be cancelled, reduced,
       varied or terminated in accordance with the terms of this Agreement);

       "Tranche A Term Commitment" means, in relation to the participation of
       any Lender in the Tranche A Term Facility, the amount stated opposite its
       name in Schedule 1 in relation to that Facility (or in the case of a
       Transferee, the amount stated in the Schedule to the relevant Transfer
       Certificate as being transferred to that Transferee), in each case as the
       same may be transferred (in whole or in part), cancelled, reduced, varied
       or terminated in accordance with the terms of this Agreement;

       "Tranche B Facility" or "Tranche B Multicurrency Revolving Facility"
       means the Tranche B multicurrency revolving loan facility not in excess
       of the Tranche B Multicurrency Revolving Commitments granted to the
       Borrower hereunder (as the same may be cancelled, reduced, varied or
       terminated in accordance with the terms of this Agreement);

       "Tranche B Multicurrency Revolving Commitment" means, in relation to the
       participation of any Lender in the Tranche B Multicurrency Revolving
       Facility, the amount (or the Equivalent Amount thereof) stated opposite
       its name in Schedule 1 in relation to the Facility (or in the case of a
       Transferee, the amount or Equivalent Amount of such amount stated in the
       Schedule to the relevant


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       Transfer Certificate as being transferred to that Transferee), in each
       case as the same may be transferred (in whole or in part), cancelled,
       reduced, varied or terminated in accordance with the terms of this
       Agreement;

       "Transfer" has the meaning given to it in Clause 25.2;

       "Transfer Certificate" means a certificate substantially in the form set
       out in Schedule 7;

       "Transferee" means a bank, financial institution or other person to which
       a Lender seeks to transfer or has transferred all or part of its rights
       and obligations hereunder;

       "United Kingdom" or "UK" means the United Kingdom of Great Britain and
       Northern Ireland;

       "United States" or "US" means the United States of America;

       "USD" means the lawful currency from time to time of the United States;

       "US Obligor" means any Obligor organised under the laws of any
       jurisdiction within the the United States;

       "VAT" means value added tax imposed in any relevant jurisdiction or any
       other tax of a substantially similar nature substituted therefor from
       time to time;

       "WCP Advance" means an Advance under a WCP Facility;

       "WCP Agreement" means an agreement between a WCP Provider and the
       Borrower relating to a WCP Facility;

       "WCP Commitment" means, in respect of any WCP Provider for a WCP
       Facility, the amount designated by the WCP Provider pursuant to Clause
       3.6.1, as such WCP Commitment may be reduced pursuant to the terms of
       this Agreement;

       "WCP Facility" means a revolving credit facility made available by a WCP
       Provider to the Borrower pursuant to Clause 3.6 and "WCP Facilities"
       means all such facilities;

       "WCP Provider" means any Lender acting through a branch or affiliate in
       respect of a WCP Commitment of that Lender;


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       "Working Capital" means in relation to a person or group of persons under
       any Approved Accounting Principles, trade and other debtors in respect of
       operating items plus prepayments and inventory less trade and other
       creditors in respect of operating items and less accrued expenses and
       accrued costs, in each case determined in accordance with such Approved
       Accounting Principles for such person or, on a consolidated basis, for
       such persons (as the case may be); and

       "Yen" means the lawful currency from time to time of Japan.

1.2    Construction of Other Terms

       In this Agreement, unless the context otherwise requires, a reference
       to:-

1.2.1  "affiliate" means in relation to any person (a) any person (other than a
       subsidiary) which, directly or indirectly, is in control of, is
       controlled by, or is under common control with such person, or (b) any
       person who is a director or officer (i) of such person, (ii) of any
       subsidiary of such person or (iii) of any person described in clause (a)
       above. For purposes of this definition, "control" of a person shall mean
       the power, direct or indirect, (i) to vote 25% or more of the securities
       having ordinary voting power for the election of directors of such
       person, whether by way of ownership of securities, contract, proxy or
       otherwise, or (ii) to direct or cause the direction of the management and
       policies of such person, whether by ownership of securities, contract,
       proxy or otherwise;

1.2.2  "assets" means business, undertaking, property, assets (tangible or
       intangible), revenues, rights and uncalled capital, wherever situated,
       present, future and contingent (including uncalled share capital), and
       every kind of interest in an asset, except that the word "contingent"
       shall not be deemed included in this definition where the definition is
       used in provisions relating to financial accounting;

1.2.3  "indebtedness" includes any obligation (whether incurred as principal or
       as surety) for the payment or repayment of money, whether present or
       future, actual or contingent, except that the word "contingent" shall not
       be deemed included in this definition where the definition is used in
       provisions relating to financial accounting;


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1.2.4  a document or other writing being "in the agreed terms" means that the
       relevant document or writing is in form and substance satisfactory to the
       Agent and has been initialled by or on behalf of the Agent and the
       Borrower (or their respective agents) on or before the date hereof;

1.2.5  an event or matter having a "Material Adverse Effect" is to be construed
       as a reference to an event or matter (a) which has or is reasonably
       likely to have a material adverse effect on the prospects, financial
       condition, business, assets or revenues of the ChiRex Group taken as a
       whole such that the Obligors, taken as a whole, will be, or are
       reasonably likely to be, unable to perform in a timely and diligent
       manner all or any of their material obligations (including, without
       limitation, payment obligations) under each of the Finance Documents or
       (b) resulting in any material term of the Finance Documents not being
       legal, valid and binding on and enforceable against any Obligor party
       thereto, subject only to the Reservations;

1.2.6  a "month" means (save where used in the expression "calendar month") a
       period starting on one day in a calendar month and ending on the
       numerically corresponding day in the next calendar month (or in a
       subsequent calendar month in the case of the plural "months"), provided
       that if:-

       (a)    any such period would otherwise end on a day which is not a
              Business Day, it shall end on the next Business Day in the same
              calendar month, or if none, on the preceding Business Day; and

       (b)    a period starts on the last Business Day in a calendar month or if
              there is no numerically corresponding day in the month in which
              that period ends, that period shall end on the last Business Day
              in that later month;

       (and references to "months" shall be construed accordingly);

1.2.7  "outstanding" under a Facility means the principal amount of all Advances
       outstanding under such Facility;

1.2.8  a "person" includes any person, firm, company, corporation, government,
       state or agency of a state or any undertaking (within the meaning of
       Section 259(1) of the Companies Act 1985) or other entity or association


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       (whether or not having separate legal personality), or any two or more of
       the foregoing;

1.2.9  "repayment" includes "prepayment" and its grammatical variations and
       cognate expressions shall be construed accordingly;

1.2.10 "subsidiary" means, with respect to any person, any corporation or other
       person more than fifty percent (50%) of whose securities or other
       ownership interests having ordinary voting power for the election of
       directors or similar representatives (other than securities having such
       power only by reason of the happening of a contingency) are, as of the
       date of determination thereof, directly or indirectly owned by such
       person or one or more of such person's subsidiaries; and

1.2.11 "winding-up" of any person includes its dissolution and/or termination
       and/or any equivalent or analogous proceedings under the law of any
       jurisdiction in which the person concerned is incorporated, registered,
       established or carries on business or to which that person is subject.

1.3    Other Provisions

       Except where a contrary intention appears, in this Agreement:-

1.3.1  a reference to an Obligor or a Finance Party is, where relevant, deemed
       to be a reference to or to include, as appropriate, their respective
       successors or assigns;

1.3.2  references to Clauses and Schedules are references to, respectively,
       clauses of and schedules to this Agreement;

1.3.3  a reference to any agreement, deed or other instrument (including the
       Finance Documents) is to be construed as a reference to that agreement,
       deed or other instrument as it may have been or hereafter be, from time
       to time, amended, varied, supplemented, restated or novated but excluding
       for this purpose any amendment, variation, supplement or modification
       which is contrary to any provision of any of the Finance Documents;

1.3.4  a reference to a statute, law, rule, regulation or statutory instrument
       is to be construed as a reference to that statute as the same may have
       been, or may from time to time hereafter be, amended or re-enacted;

1.3.5  a time of day is a reference to London, England time;


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1.3.6  the index to and the headings in this Agreement are inserted for
       convenience only and are to be ignored in construing this Agreement;

1.3.7  references to the singular shall include the plural and vice versa, and
       reference by way of masculine pronoun or adjective shall include
       references by way of the feminine, and vice versa ; and

1.3.8  accounting terms are to be construed in accordance with the Approved
       Accounting Principles.

2.     THE FACILITIES

2.1    The Facilities

2.1.1  The Lenders grant to the Borrower, upon the terms and subject to the
       conditions of this Agreement, the Facilities.

2.2    Purpose

2.2.1  Tranche A Term Facility: The proceeds of the Advance under the Tranche A
       Term Facility shall be used by the Borrower to advance to ChiRex (Annan)
       Limited the consideration for the purchase of the Assets from Glaxo Group
       Limited pursuant to the Sale and Purchase Agreement.

2.2.2  Tranche B Multicurrency Revolving Facility: The proceeds of any Advance
       under the Tranche B Multicurrency Revolving Facility (including WCP
       Advances, except as otherwise restricted by Clause 3.6) shall be used by
       the Borrower (a) up to the principal amount of GBP 1,000,000, for the
       purpose for which proceeds under the Tranche A Facility may be used and
       (b) otherwise, to advance to any member of the ChiRex Group for general
       corporate purposes of such member of the ChiRex Group.

2.2.3  Financial Assistance: No amount drawn down hereunder shall be applied by
       an Obligor in a manner which may be prohibited by any financial
       assistance or other similar laws in any relevant jurisdiction.

3.     PARTICIPATION OF LENDERS

3.1    Basis of Participation


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       Subject to the provisions of this Agreement, each Lender will participate
       in each Advance in the proportion which (i) in the case of an Advance
       under the Tranche A Term Facility, its Commitment in relation to such
       Facility as at the Drawdown Date bears to the undrawn portion of the
       Total Commitments of the Lenders in relation to such Facility as at such
       date, and (ii) in the case of an Advance under the Tranche B
       Multicurrency Revolving Facility, its Net Tranche B Multicurrency
       Revolving Commitment in relation to such Facility as at the Drawdown Date
       bears to the undrawn portion of the Total Commitments of the Lenders in
       relation to such Facility as at such date.

       None of the Lenders is obliged to participate in an Advance to the extent
       that to do so would result in the amount outstanding to it under the
       relevant Facility exceeding its Commitment in respect of that Facility.

3.2    Lending Office

3.2.1  Each Lender will participate in each Advance as aforesaid through its
       Lending Office.

3.2.2  If any Lender changes any Lending Office, that Lender agrees to notify
       the Agent and the Borrower promptly of such change and, until it does so,
       the Agent and the Borrower shall be entitled to assume that no such
       change has taken place.

3.3    Rights and Obligations of Finance Parties

3.3.1  The rights and obligations of each of the Finance Parties under the
       Finance Documents are several. Failure of any Finance Party to observe
       and perform its obligations under any Finance Document shall neither:-

       (a)    result in any other Finance Party incurring any liability
              whatsoever; nor

       (b)    relieve the Borrower or any other Finance Party from their
              respective obligations under the Finance Documents.

3.3.2  Notwithstanding any other provision of any Finance Document, the
       interests of each Finance Party are several and the total amounts
       outstanding at any time under the Finance Documents and due to each
       Finance Party constitute separate and independent debts.

3.4    Enforcement of Rights


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       Each Finance Party has the right to protect and enforce its rights
       arising out of the Finance Documents and it will not be necessary for any
       other Finance Party to be joined as an additional party in any
       proceedings brought for the purpose of protecting or enforcing such
       rights.

3.5    Syndication

       The Borrower acknowledges that, without limitation of the provisions of
       Clause 25, the Lenders may assign or transfer their respective rights
       under this Agreement ("Syndication") and the Borrower undertakes to
       assist and co-operate with the Joint Arrangers in Syndication in such
       manner and to such extent as the Joint Arrangers may from time to time
       each reasonably request including, without limitation, by:-

       (a)    providing and causing the Borrower's advisers to provide the Joint
              Arrangers with all reasonable information deemed necessary by the
              Joint Arrangers to complete Syndication, including but not limited
              to information and evaluations prepared by the Borrower and its
              advisers;

       (b)    assisting in the preparation of an Information Memorandum;

       (c)    making available officers of the Borrower and ChiRex Inc. from
              time to time and, as may reasonably be requested, causing such
              officers to attend and make presentations regarding the business
              and prospects of the Borrower and ChiRex Inc., as appropriate, at
              a meeting or meetings of Lenders or prospective Lenders;

       (d)    arranging and conducting appropriate Borrower site visits for the
              Joint Arrangers;

       (e)    selecting Interest Periods having a duration of not more than one
              month in respect of all Advances made for the first six months
              following the date of this Agreement or, if earlier, the date on
              which the Agent notifies the Borrower that in the Agent's
              determination Syndication is completed, which the Agent hereby
              agrees to do promptly upon completion of Syndication; and

       (f)    refraining and causing its subsidiaries to refrain, from placing
              any of their respective borrowings in the English, French, Spanish
              or international 


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              financial or capital markets until the earlier of (i) six months
              after the date of this Agreement, and (ii) completion of such
              Syndication as notified to the Borrower by the Agent.

3.6    The WCP Facilities

3.6.1  (a)    If a WCP Provider so agrees, at the request of the Borrower, a WCP
              Provider may designate by notice to the Agent all or part of its
              Tranche B Multicurrency Revolving Commitment as being utilised by
              its provision of a WCP Commitment in the amount designated in
              respect of a WCP Facility for the Borrower up to a maximum
              aggregate amount of GBP 2,000,000 or the Equivalent Amount
              thereof.

       (b)    Under no circumstance shall the aggregate of any WCP Provider's
              WCP Commitments exceed such WCP Provider's Tranche B Multicurrency
              Revolving Commitment.

       (c)    Subject to the terms of this Agreement,

(i)    while and to the extent a WCP Facility is made available for drawing by
       the Borrower, the Tranche B Multicurrency Revolving Commitment of the WCP
       Provider for that WCP Facility shall be reduced by the amount of its WCP
       Commitment in respect of that WCP Facility, as set forth in the
       definition of Net Tranche B Multicurrency Revolving Commitment; and

(ii)   the Borrower may cancel any undrawn element of a WCP Facility at any
       time, and in any such event or upon the expiration of the WCP Commitment
       for that WCP Facility, the Net Tranche B Multicurrency Revolving
       Commitment of the WCP Provider for that WCP Facility shall automatically
       be increased by the amount so cancelled or expired; provided that such
       WCP Provider's Net Tranche B Multicurrency Revolving Commitment shall not
       be increased in excess of its Tranche B Multicurrency Revolving
       Commitment.

3.6.2  Each WCP Facility shall be made available to the Borrower upon the terms
       of this Agreement, as follows:-

       (a)    WCP Advances may be in the form of cash Advances, letters of
              credit or revolving credit guarantees as agreed between the
              relevant WCP Provider in the applicable WCP Agreement.


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       (b)    WCP Advances under a WCP Facility shall, except as otherwise
              provided, be made available to the Borrower on the same terms and
              conditions (including without limitation the terms and conditions
              relating to interest, payments, change in circumstances, defaults,
              etc.) under which Advances under the Tranche B Multicurrency
              Revolving Facility are made available to the Borrower under this
              Agreement, provided that for purposes of Clauses 2, 3 and 5 to 11
              (inclusive):

(i)    the Lending Office(s) of a WCP Provider for purposes of its WCP Facility
       may be different from the Lending Office(s) it designates for other
       purposes under this Agreement;

(ii)   except as set forth in Clause 3.6.1, all notices to be given by or to the
       Agent in respect of a Tranche B Multicurrency Revolving Advance shall, in
       respect of a WCP Advance, be given by or to (as applicable) the WCP
       Provider for the relevant WCP Facility (and references to the Agent and
       its address in the relevant provisions of such clauses shall be deemed
       references to the relevant WCP Provider and its address for this
       purpose);

(iii)  all determinations to be made by the Agent in respect of a Tranche B
       Multicurrency Revolving Advance shall, in respect of a WCP Advance, be
       made by the relevant WCP Provider (and references to the Agent in the
       relevant provisions of such clauses shall be deemed references to the
       relevant WCP Provider for this purpose);

(iv)   all payments which, in respect of a Tranche B Multicurrency Revolving
       Advance are required to be made to the Agent hereunder shall, in respect
       of a WCP Advance to the Borrower, be made to the WCP Provider in respect
       of those WCP Advances (and references to the Agent and its address in the
       relevant provisions of such clauses shall be deemed references to the
       relevant WCP Provider and its address for this purpose); and

(v)    each WCP Advance shall be in such minimum amount and integral multiples
       as is agreed between the relevant WCP Provider and the Borrower in the
       applicable WCP Agreement.

       (c)    The foregoing notwithstanding, the Borrower and WCP Provider in
              relation to a WCP Facility may agree in a WCP Agreement between
              them to vary the interest rate applicable to WCP Advances under
              the WCP Facility, the number of WCP Advances that may be


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              outstanding at any one time, or the form of or requirement for any
              Drawdown Request or the notice required to make a drawing of a WCP
              Advance under that WCP Facility, and payment and amount of fees;
              provided that such WCP Agreement may not amend, supplement or vary
              this Agreement in any other respect without the consent of the
              Agent acting at the direction of the Majority Lenders, or, to the
              extent required by the other provisions of this Agreement, the
              Lenders.

       (d)    In addition to the foregoing, Clause 8.3.4 shall not apply in
              respect of any WCP Advance.

3.7    Certain Adjustments Relating to WCP Facilities

3.7.1  Following the occurrence and during the continuance of an Event of
       Default:-

       (a)    each WCP Provider shall promptly notify the Agent of any Recovery
              made by it from the Borrower and/or any loss or expense suffered
              by it in connection with the failure to repay in full, in each
              case by reference to the WCP Facility or WCP Facilities to which
              it is a party; and

       (b)    in the event of a shortfall as regards any or all of the Obligors
              under the Finance Documents, the Agent shall calculate the
              necessary adjustments between that WCP Provider and the other
              Lenders so that, as closely as is practicable, each Lender shares
              any loss suffered by all the Lenders (including the WCP Provider)
              in the proportion which that Lender's Commitments under the
              Facilities bears to the Total Commitments under the Facilities.

       (c)    The Lenders (including each WCP Provider) agree to accept as
              conclusive (in the absence of manifest error) the calculations of
              the Agent under paragraph (b) above and to make such consequential
              payments as between themselves as may be necessary to achieve the
              proportionate loss sharing contemplated by that paragraph (b) and
              to give effect to Clause 19.

3.7.2  Any consequential payment made by a Lender under Clause 3.7.1 above is
       without prejudice to the obligations under this Agreement of the Borrower
       to pay all amounts due and payable under this Agreement.

4.     CONDITIONS PRECEDENT


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4.1    Initial conditions precedent

4.1.1  The obligations of the Lenders to make any Advance available to the
       Borrower under this Agreement are conditioned upon the Agent and its
       legal advisers having received the following documents and evidence in
       all respects (except where otherwise specified) in form and substance
       satisfactory to the Agent and its legal advisers by 12:00 noon on the
       first Business Day prior to the Initial Drawdown Date:-

       (a)    a copy, certified as of the Initial Drawdown Date as true and
              complete by a duly authorised representative of the relevant
              Obligor, of:

(i)    the constitutional documents of each Obligor, including evidence of due
       incorporation, together with satisfactory search results of any public
       corporate registers of that Obligor;

(ii)   board (or other appropriate governing body) resolutions of each Obligor
       (A) approving the transactions and the matters contemplated by each of
       the Finance Documents, and (B) authorising or granting a power of
       attorney to a specified person or persons to (x) execute on its behalf
       each of the Finance Documents to which it is a party, and (y) give all
       notices, requests, instructions, certificates and other documents for
       that Obligor in connection with each of the Finance Documents to which it
       is a party;

(iii)  all other corporate, trust or other applicable authorisations and actions
       of it required (including without limitation any resolutions of
       shareholders or approvals of beneficiaries) to enable it to enter into,
       execute and perform those of the Finance Documents to which it is, or is
       to be, a party;

(iv)   specimen signatures of the signatories authorised by each Obligor in the
       board (or other appropriate governing body) resolutions described in
       Clause 4.1.1(a)(ii) to sign Financing Documents to which it is or is to
       be a party; and

(v)    all other resolutions, powers, declarations, approvals, consents and
       licenses (corporate, official or otherwise) necessary or appropriate for
       the entry into and performance by each Obligor of the Finance Documents
       to which it is or is to be a party, and for the enforceability and
       validity thereof;


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       (b)    duly and unconditionally executed counterparts (except where such
              documents are expressly governed (in whole or in part) by Scottish
              law, in which case such documents shall not be executed in
              counterparts) of:-

(i)    this Agreement; and

(ii)   each of the Security Documents.

       (c)    legal opinions properly addressed to the Agent and Lenders from:-

              (i)    Cravath, Swaine & Moore, U.S. legal advisers to the ChiRex
                     Group;

              (ii)   Dibb Lupton Alsop, English legal advisers to the ChiRex
                     Group; and

              (iii)  O'Melveny & Myers LLP, legal advisers to the Agent;

       (d)    (i) in relation to the Annan Facility, evidence that:

                     (A) the consummation of the transactions contemplated in
                     the Sale and Purchase Agreement and entry into the Supply
                     Agreement will occur on terms and conditions acceptable to
                     the Agent substantially contemporaneously with the Initial
                     Drawdown; and

                     (B) an executed and completed letter of obligation from
                     Brodies WS, "Disposition" in favour of ChiRex (Annan)
                     Limited, a wire transfer in respect of (i) stamp duty on
                     the Disposition in the amount of GBP 240,000 and (ii)
                     registration dues on the Disposition and Standard Security
                     in the amount of GBP 7,522, and the prior writs and land
                     registration forms 1 and 4 in respect of the Disposition,
                     have each been delivered to Tods Murray, Scottish counsel
                     for the Agent; and

              (ii) in relation to the Dudley Facility, evidence that the
              Security Interest held by Midland Bank plc has been paid and
              discharged in full substantially contemporaneously with the
              Initial Drawdown.


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       (e)    delivery of share certificates and share transfer forms and/or
              evidence of the relevant recording on the share registers with
              respect to the shares of ChiRex America Inc., the Borrower, ChiRex
              (Dudley) Limited and ChiRex (Annan) Limited, and the Holdings
              Note, the Annan Note and the Multiborrower Revolving Note, all as
              pledged pursuant to the Security Documents, and/or any other
              evidence that the Security Interests created thereby are
              appropriately perfected or will be perfected upon registration
              under applicable law;

       (f)    Environmental Report;

       (g)    Due Diligence Report (Legal);

       (h)    Business Plan;

       (i)    Operating Budget;

       (j)    Accountants' Report and Industry Report;

       (k)    in each case, unless the relevant report itself is addressed to
              the Agent and each of the Lenders, reliance letters addressed to
              the Agent and each of the Lenders in form and substance
              satisfactory to the Agent with respect to each of (i) the
              Environmental Report, to the extent it relates to the Annan
              Facility, (ii) the Due Diligence Report (Legal) as described in
              item (ii), (iii) and (iv) of the definition thereof, (iii) the
              Accountants' Report, and (iv) the Industry Report;

       (l)    analyses and evidence of insurance complying with Clause 13.2.6
              (Insurances) in scope, form and substance reasonably satisfactory
              to the Agent;

       (m)    audited consolidated financial statements for ChiRex Inc. for the
              Accounting Reference Period ended 31st December, 1996 and
              unaudited interim financial statement for the Accounting Quarter
              ended 30th June, 1997;

       (n)    each of the financial statements and other materials required
              pursuant to Clause 13.3.4 (Financial Statements and Operating
              Budget);

       (o)    copies of each of the agreements, deeds or other instruments, in
              each case containing covenants, events of default and matters
              relating to requirements for repayment in advance of scheduled


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              maturity in form and substance reasonably satisfactory to the
              Agent, evidencing the Continuing Indebtedness, certified as of the
              Initial Drawdown Date by a duly authorised representative of the
              Borrower;

       (p)    evidence that the agents for service of process named in Clause
              30.2 have accepted their respective appointments for the purposes
              of this Agreement and the other Finance Documents; and

       (q)    evidence of the payment of the fees specified in Clause 11.1.1(b).

4.1.2  When the Agent is satisfied that such conditions have been fulfilled, the
       Agent will give notice to that effect to the Borrower and each of the
       Lenders.

4.2    Additional Conditions Precedent for All Advances

4.2.1  The obligations of the Lenders to make any Advance to the Borrower is
       subject to the following further conditions precedent that on both the
       date of the relevant Drawdown Request and the relevant Drawdown Date,
       unless waived by the Agent acting in accordance with Clause 26:-

       (a)    no Event of Default or Potential Event of Default has occurred and
              continues unremedied or will occur as a result of the making of
              the Advance; and

       (b)    the representations and warranties required to be made in
              accordance with Clause 12 are true and accurate in all material
              respects in each case by reference to the facts and circumstances
              then subsisting and will remain true and accurate immediately
              after the Advance is made.

4.2.2  Each Drawdown must fall on a Business Day on or before the expiry of the
       Availability Period for the relevant Facility. Any amounts not drawn on
       or before the expiry of the Availability Period for the Facility shall be
       cancelled.

5.     DRAWDOWN PROCEDURES AND LENDERS' PARTICIPATIONS;

5.1    Drawdown of Advances

5.1.1  Whenever the Borrower wishes to borrow an Advance, the Borrower must
       deliver to the Agent a duly completed Drawdown Request not later than
       10.00 a.m. three Business 


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       Days prior to the proposed Drawdown Date (including with respect to the
       Initial Drawdown Date).

5.1.2  A Drawdown Request for an Advance delivered to the Agent must be in the
       form set out in Schedule 3 and must specify each of the following:-

       (a)    the proposed Drawdown Date for the Advance (which must be a
              Business Day falling within the Availability Period);

       (b)    the amount of the Advance which amount must be a minimum of GBP
              1,000,000 or the Equivalent Amount thereof and an integral
              multiple of GBP 500,000 or the Equivalent Amount thereof, except
              to the extent of variations from such amounts for rounding
              purposes approved by the Agent;

       (c)    the duration of the first Interest Period applicable to the
              Advance, which must comply with Clause 8.3;

       (d)    the account to which the proceeds of the Advance are to be paid;
              and

       (e)    the purpose for which the Advance is requested.

5.1.3  In no event may the amount specified in a Drawdown Request be such that
       the Loan would thereby exceed the then Total Commitments. If, however,
       the amount specified in a Drawdown Request exceeds the then Total
       Commitments, and the amount of that excess may reasonably be attributed
       to exchange rate fluctuations on or after the date a Drawdown Request is
       given, the Agent in its sole discretion may agree with the Borrower to
       adjustments, complying with the terms and conditions of this Agreement,
       in the amount of any Loan requested pursuant to such Drawdown Request so
       that the amounts requested pursuant to such Drawdown Request comply with
       this Clause 5.1.3. The Agent shall notify the Lenders promptly after any
       such adjustment is made, and all expenses, losses, damages and liability
       of the Lenders arising out of any such adjustments shall be for the
       account of the Borrower pursuant to Clause 27.1 (General Indemnity and
       Breakage Costs).

5.1.4  A Drawdown Request in relation to an Advance, once given, may not be
       withdrawn or revoked.

5.1.5  Advances under the Tranche A Term Facility may only be requested for the
       Initial Drawdown Date.


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5.1.6  Not more than fifteen separate Tranche B Multicurrency Revolving Advances
       may be outstanding at any time.

5.1.7  (a)    The Borrower may not request the drawdown of an Advance in a
              currency other than DEM, FF, LIT, GBP, CHF, Yen or USD (unless the
              Agent has confirmed in writing to the Borrower that such other
              currency is freely available to all the Lenders and is one in
              which dealings regularly occur in the London interbank market).

       (b)    Notwithstanding Clause 5.1.7(a), if before 9.15 a.m. (London time)
              on the proposed Drawdown Date for a utilisation to be denominated
              in a currency other than DEM, FF, LIT, GBP, CHF, Yen or USD:-

(i)    the Agent receives notice from a Lender that it is impracticable for the
       Lender to fund its participation for the relevant Interest Period in such
       currency in the ordinary course of its business in the London interbank
       market; or

(ii)   the drawing of the proposed Advance in such currency could, in the
       opinion of the Agent, be reasonably likely to contravene any applicable
       law or regulation;

              then:-

              (A)    the Agent shall promptly and in any event before 10.00 a.m.
                     on that Drawdown Date notify the Borrower;

              (B)    if the Agent receives notice from the Borrower by 11.00
                     a.m. on the relevant Drawdown Date, the drawdown shall not
                     be made;

              (C)    if the Agent does not receive any notice under
                     sub-paragraph (B) above, the drawdown will be denominated
                     instead in GBP and there shall be substituted in the
                     definition of "LIBOR" in Clause 1.1 the time "1.00 p.m."
                     for the time "11.00 a.m."; and

              (D)    the Borrower shall forthwith on demand indemnify each
                     Lender against any liability which that Lender incurs as a
                     consequence of the operation of this Clause 5.1.7(b).

5.2    Lenders' Participations


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5.2.1  Subject to the provisions of this Agreement, each Lender will make
       available to the Agent its Participation Proportion of the relevant
       Advance on the relevant Drawdown Date in accordance with Clause 9.1.1
       (Payments).

5.2.2  If, prior to an Advance being made, a Lender's Commitment has been or
       will be wholly cancelled or terminated pursuant to this Agreement, such
       Lender will not participate in such Advance.

5.3    Notice to the Lenders of a Proposed Drawdown

       Whenever the Agent receives a Drawdown Request which complies with the
       requirements of Clause 5.1, the Agent will promptly give notice to each
       of the Lenders of (a) the details of the requested Advance, and (b) the
       amount of such Lender's participation (or deemed participation) in the
       relevant Advance.

6.     REPAYMENT OF ADVANCES

6.1    Repayment of Tranche A Term Loans

6.1.1  On each Repayment Date, the Borrower shall repay or cause the repayment
       (as applicable) of the aggregate amount of the Tranche A Term Loan set
       forth opposite such date in Schedule 2.

6.1.2  If any Repayment Date is not a Business Day it will be adjusted to fall
       on the next succeeding Business Day unless the result of such adjustment
       would be to carry that Repayment Date into another calendar month, in
       which event such Repayment Date shall be the last preceding Business Day.

6.1.3  Any amount of the Tranche A Term Loan repaid under this Agreement may not
       be redrawn and the relevant Tranche A Term Commitment shall be reduced by
       an amount equal to the amount of such Loan so repaid.

6.2    Repayment of Tranche B Multicurrency Revolving Advances

6.2.1  Each Advance under the Tranche B Multicurrency Revolving Facility shall
       be borrowed for a period equal to the Interest Period selected in
       relation to such Advance. The Borrower shall accordingly repay each such
       Advance on the last day of such Interest Period in the currency in which
       such Advance was made to the Borrower.


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6.2.2  The Borrower shall ensure that the aggregate principal amount of all
       Tranche B Multicurrency Revolving Advances from time to time outstanding
       does not exceed the aggregate amount of the Tranche B Multicurrency
       Revolving Facility from time to time (including Equivalent Amounts in
       respect of Advances not denominated in GBP).

6.2.3  Subject to the provisions of this Agreement, Tranche B Multicurrency
       Revolving Advances repaid in accordance with Clause 6.2.1 above shall be
       capable of being redrawn by the Borrower.

6.2.4  Subject to the terms of this Agreement: (i) on 31st December, 2000, the
       Borrower shall repay such portion of the outstanding Tranche B
       Multicurrency Revolving Advances, if any, required to cause the total
       outstanding Tranche B Multicurrency Revolving Advances to equal GBP
       19,000,000 (or the Equivalent Amount thereof) or less (and the Tranche B
       Multicurrency Revolving Commitments shall be decreased accordingly); (ii)
       on 31st December, 2001, the Borrower shall repay such portion of the
       outstanding Tranche B Multicurrency Revolving Advances, if any, required
       to cause the total outstanding Tranche B Multicurrency Revolving Advances
       to equal GBP 16,000,000 (or the Equivalent Amount thereof) or less (and
       the Tranche B Multicurrency Revolving Commitments shall be decreased
       accordingly); and (iii) on 31st December, 2002, the Borrower shall repay
       all remaining outstanding Tranche B Multicurrency Revolving Advances.

6.2.5  Subject to the terms of this Agreement, if any Tranche B Multicurrency
       Revolving Advance (the "New Revolving Advance") is to be made to the
       Borrower on the day on which another Tranche B Multicurrency Revolving
       Advance denominated in the same currency (the "Maturing Revolving
       Advance") is due to be repaid (the "Revolving Maturity Date") by the
       Borrower then (subject to there being no Event of Default or Potential
       Event of Default), as between each Lender and the Borrower, the amount to
       be repaid by the Borrower by way of Maturing Revolving Advance shall be
       set off against the amount of the New Revolving Advance to be advanced by
       each Lender (in respect of its participation) and the party to whom the
       smaller amount is to be paid shall advance or repay (as appropriate) to
       the party to whom the larger amount is to be paid the difference between
       the two amounts on the Revolving Maturity Date.

7.     PREPAYMENT AND CANCELLATION


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7.1    Voluntary Prepayments

7.1.1  Subject to the order of application set forth in Clause 7.3.1, the
       Borrower may voluntarily prepay the whole or part of any Advance on the
       last day of an Interest Period (or on any other Business Day subject to
       payment of any breakage costs thereby incurred by any Lender in
       accordance with Clause 27.1) relating thereto provided that the Agent has
       received from the Borrower not less than ten Business Days' notice of the
       proposed date and the amount of the prepayment.

7.1.2  If the Loans are to be prepaid voluntarily in part, the aggregate amount
       of the partial prepayment must be a minimum of GBP 1,000,000 or the
       Equivalent Amount thereof and an integral multiple of GBP 500,000 or the
       Equivalent Amount thereof.

7.1.3  A prepayment made in accordance with the terms of this Clause 7 may be
       made without premium or penalty.

7.2    Mandatory Prepayments

7.2.1  Asset Disposals

       If the Borrower disposes of an asset (other than:-

       (a)    a disposal permitted by Clauses 13.2.8(a), (b) or (c), or

       (b)    disposals permitted by Clauses 13.2.8(d) and (e) up to an
              aggregate amount of Net Cash Proceeds for all such disposals
              described in this sub-clause (b) of GBP 2,500,000 (or its
              equivalent) following the date of this Agreement),

       the Net Cash Proceeds of such disposal shall be applied by the Borrower
       as promptly as practicable in prepayment of the outstandings under this
       Agreement in accordance with Clause 7.3.1 below.

7.2.2  Cashflow

       Before the Achievement Date only, the Borrower will once per annum make a
       prepayment to be applied against the outstandings under this Agreement in
       accordance with Clause 7.3.1 below within 120 days of the expiry of each
       Accounting Reference Period (beginning with the Accounting Reference
       Period ended 31st December 1998) in the amount of 50% of the aggregate of
       the unconsolidated 


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       Cashflow, without allowing for any duplication, of each Obligor
       (determined in accordance with the respective applicable Approved
       Accounting Principles) for the Accounting Reference Period then ended, if
       a positive number.

7.2.3  Change of Control

       Immediately upon a Change of Control:

       (a)    the Borrower will prepay all Advances, accrued interest thereon
              and all other sums payable under this Agreement and the other
              Finance Documents; and

       (b)    the unborrowed amount of all Facilities will be cancelled and the
              Commitment of each Lender in respect of each Facility shall be
              reduced to zero.

7.3    Prepayments; Order of Application

7.3.1  Partial prepayments made pursuant to Clauses 7.1 and 7.2 will be applied
       by the Borrower first, to the permanent prepayment of the Tranche A Term
       Loan (to be applied pro-rata against the scheduled remaining repayments
       thereof); and second, to the permanent prepayment of the Tranche B
       Multicurrency Revolving Advances.

7.3.2  Amounts applied in permanent repayment of the Tranche B Multicurrency
       Revolving Advances may not be redrawn and, upon any such prepayment, each
       Lender's Tranche B Multicurrency Revolving Commitment shall be reduced
       proportionately.

7.4    Prepayments during Interest Periods

7.4.1  Prepayments pursuant to Clauses 7.1, 7.2 and 7.3 applied to the
       obligations of the Borrower hereunder shall be subject to payment of any
       breakage costs incurred by any Finance Party, calculated in accordance
       with Clause 27.1 (General Indemnity and Breakage Costs). If requested by
       the Borrower, the Agent shall deposit the proceeds of prepayment in an
       interest-bearing account established on terms (including terms as to
       security) in all respects satisfactory to the Agent until the end of the
       Interest Period then current and apply such funds (together with any
       interest accrued thereon) toward the required prepayment on the last day
       of such Interest Period.

7.5    Cancellation


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7.5.1  The Borrower may cancel the whole or any part (but if in part, in a
       minimum amount of GBP 1,000,000 or the Equivalent Amount thereof and in
       integral multiples of GBP 500,000 or the Equivalent Amount thereof) of
       the Tranche B Multicurrency Revolving Facility undrawn when the notice of
       cancellation takes effect if it gives three Business Days' written notice
       of cancellation to the Agent. Cancellation made in accordance with the
       terms of this Clause 7 may be made without penalty.

7.5.2  Upon each cancellation of the Tranche B Multicurrency Revolving Facility,
       the Borrower shall be required to make such repayments thereof as are
       necessary so that the Tranche B Multicurrency Revolving Advances
       outstanding at the time of the cancellation do not exceed the total
       Tranche B Multicurrency Revolving Commitments after giving effect to such
       cancellation. Upon any such cancellation taking effect the maximum amount
       of the Tranche B Multicurrency Revolving Facility shall be accordingly
       reduced and the amount of each Lender's Tranche B Multicurrency Revolving
       Commitment (if any) shall be reduced proportionately.

7.6    General

7.6.1  No prepayment may be made except at the times and in the manner expressly
       provided by this Agreement.

7.6.2  No amount prepaid in respect of the Tranche A Term Facility may be
       subsequently re-drawn.

7.6.3  All prepayments shall be made together with interest accrued thereon up
       to the date of prepayment and any other amounts then due and payable
       under any Finance Document.

7.6.4  The Agent shall notify the Lenders promptly upon receipt by it of a
       notice of prepayment.

7.6.5  All notices of prepayment and all notices of cancellation given by the
       Borrower are irrevocable.

8.     INTEREST

8.1    Interest Rate

8.1.1  Each Advance will bear interest during each Interest Period applicable to
       that Advance at the rate per annum determined by the Agent to be the sum
       of (a) the applicable Margin, (b) LIBOR for such Interest Period, 


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       and (c) in the case of Advances denominated in GBP or another currency
       subject to Mandatory Liquid Asset Costs, Mandatory Liquid Asset Costs.

8.1.2  Interest will be calculated on the basis of actual days elapsed and a
       360-day year (other than interest in respect of Advances denominated in
       GBP, which will be calculated on the basis of a year of 365 days), and
       will accrue from day to day from, and including, the first day of each
       Interest Period.

8.1.3  If requested to do so, each Reference Lender shall use its reasonable
       endeavours to supply a quotation to the Agent for the purposes of
       determining LIBOR for a particular Interest Period. If any Reference
       Lender does not do so, the relevant arithmetic mean shall be determined
       on the basis of the quotations supplied by the remaining Reference
       Lenders. At such time as there are three Reference Lenders, if no, or
       only one, Reference Lender supplies a quotation, Clause 8.5 shall apply;
       provided that if there are only two Reference Lenders and one supplies a
       quotation, Clause 8.5 shall not apply in such case.

8.2    Payment of Interest

       The Borrower will pay interest accrued on each Advance to the Agent for
       the account of the Lenders in arrears on the last day of each Interest
       Period applicable to that Advance, provided that where such Interest
       Period is of a duration of longer than three months, accrued interest in
       respect of the relevant Advance shall be paid every three months during
       such Interest Period and on the last day of such Interest Period.

8.3    Selection of Interest Periods

8.3.1  Subject to Clause 3.5.(e), the duration of each Interest Period will be a
       period of one, two, three or six months (or such other period as may be
       agreed between the Borrower and all of the Lenders) as notified by the
       Borrower to the Agent not later than 10.00 a.m. three Business Days prior
       to the commencement of such Interest Period, provided that:-

       (a)    the first Interest Period in relation to an Advance will commence
              on the Drawdown Date relating thereto and each subsequent Interest
              Period relating to such Advance (or part thereof) will commence on
              the expiry of the preceding Interest Period relating thereto;


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       (b)    if the Borrower fails to select an Interest Period, then, subject
              as provided in this Clause 8.3, the Borrower will be deemed to
              have selected an Interest Period of three months; and

       (c)    if all or part of a Tranche A Term Advance is required to be
              repaid on a Repayment Date to ensure that the Borrower complies
              with its obligations under Clause 6.1.1 and if an Interest Period
              relative to that Advance would, but for the operation of this
              sub-clause (c), extend beyond such Repayment Date, then if
              necessary such Advance shall be split into two separate Advances
              (such additional Advance not to be counted for the purposes of
              sub- clause (d) below), one of which shall be in an amount equal
              to the amount required to be repaid and having an Interest Period
              commencing upon the expiry of the immediately preceding Interest
              Period and expiring on the relevant Repayment Date, the other
              Advance being for the balance of the amount of the original
              Advance; and

       (d)    the Borrower will not be entitled to select more than three
              concurrent Interest Periods in relation to the Advances.

8.3.2  If any Interest Period would, but for this Clause 8.3.2, end on a day
       which is not a Business Day, that Interest Period shall be extended to
       the next succeeding Business Day unless the result of such extension
       would be to carry such Interest Period into another calendar month, in
       which event such Interest Period shall end on the last preceding Business
       Day.

8.3.3  No Interest Period for any Advance shall expire after the Final Repayment
       Date.

8.3.4  The Agent will notify:-

       (a)    the Lenders of each Interest Period applicable to each Advance
              promptly upon the same being determined; and

       (b)    the Lenders and the Borrower of the rate of interest applicable to
              such Interest Period as soon as it is determined under this
              Agreement.

8.4    Interest on Unpaid Sums


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8.4.1  If the Borrower fails to pay any sum due from it under this Agreement or
       any other Finance Document on its due date (an "unpaid sum"), the
       Borrower will pay default interest on such unpaid sum from its due date
       to the date of actual payment (after as well as before judgement or
       decree) at a rate (the "Default Rate") determined by the Agent to be 2
       per cent per annum above:-

       (a)    if the unpaid sum is principal which has fallen due prior to the
              expiry of the relevant Interest Period, the rate applicable to
              such principal immediately prior to the date it so fell due (but
              only for the period from such due date to the end of the relevant
              Interest Period); or

       (b)    in any other case (including principal falling within (a) above
              once the relevant Interest Period has expired), the rate which
              would be payable if the unpaid sum was an Advance made for a
              period equal to the period of non-payment divided into successive
              Interest Periods of such duration as shall be selected by the
              Agent (a "Default Interest Period").

8.4.2  Default interest will be payable by the Borrower on demand by the Agent
       and will be compounded at the end of each Default Interest Period.

8.4.3  The Agent will promptly notify the Borrower and the Lenders of each
       determination of the Default Rate and each selection of a Default
       Interest Period.

8.5    Market Disruption

8.5.1  If prior to the commencement of an Interest Period (an "Affected Interest
       Period"):-

       (a)    the Agent, after consultation with the Lenders, determines that,
              by reason of circumstances affecting the London interbank market
              or the financial markets generally, adequate and fair means do not
              or will not exist for ascertaining the interest rate applicable to
              the Affected Interest Period; or

       (b)    Lenders whose Relevant Amounts exceed 51% of Relevant Amounts of
              all Lenders notify the Agent that LIBOR would not accurately
              reflect the cost to such Lenders of making or maintaining their
              respective Participations in the relevant Advance during the
              Affected Interest Period; or


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       (c)    the appropriate page of the Telerate Display Screen does not list
              any appropriate quotations and (i) at such time as there are three
              Reference Lenders none or only one of the Reference Lenders has
              notified a rate to the Agent for the purposes of determining LIBOR
              for the Affected Interest Period, or (ii) at such time as there
              are two Reference Lenders none of the Reference Lenders has
              notified a rate to the Agent for the purposes of determining LIBOR
              for the Affected Interest Period;

       the Agent shall give notice of such event to the Borrower and the Lenders
       (a "Suspension Notice"). If such Suspension Notice shall be given prior
       to the receipt by the Agent of a Drawdown Request, the Borrower's right
       to borrow and issue a Drawdown Request in respect of Advances hereunder
       shall be suspended during the continuance of such circumstances.

8.5.2  If at the time of the Suspension Notice a Drawdown Request has been given
       pursuant to Clause 5.1.1, such Drawdown Request shall, unless the
       Borrower and the Agent (after consultation with the Lenders) otherwise
       agree, be deemed to have been cancelled and the Advance concerned shall
       not be made.

8.5.3  Subject to Clause 8.5.4, during the 21 days following the giving of the
       Suspension Notice, the Agent, the Borrower and the Lenders shall
       negotiate in good faith in order to arrive at a mutually acceptable
       substitute basis for calculating the alternative interest rate or (as the
       case may be) an alternative basis for the relevant Lender to fund or
       continue to fund the affected Advance during the Affected Interest Period
       on the basis that the net return to the Lenders or the relevant Lender
       shall be no less than had the event described in Clause 8.5.1 not
       occurred. If within such 21 day period such parties shall agree in
       writing upon a substitute basis, such substitute basis shall apply in
       accordance with its terms. If such parties fail to agree on a substitute
       basis within such 21 day period, the Agent (after consultation with the
       Lenders or, as the case may be, the relevant Lender) shall certify to the
       Borrower (such certificate to be conclusive in the absence of manifest
       error, and binding on all concerned) the basis upon which interest in
       relation to the Affected Interest Period is to be fixed or (as the case
       may be) the basis upon which the relevant Lender will fund or continue to
       fund its participation in the Advance during the Affected Interest
       Period. Such basis (in relation to the said rate of interest) may include
       the substitution of the cost of 


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       funds to such Lenders from other sources and for different funding
       periods, plus the Margin (plus, in the case of Advances in GBP or another
       currency subject to Mandatory Liquid Asset Costs, Mandatory Liquid Asset
       Costs), and may be retroactive to the beginning of the Affected Interest
       Period. Such interest shall be calculated at the rate specified in the
       Agent's certificate.

8.5.4  Notwithstanding the foregoing, the Borrower may, at any time after the
       Agent shall have set a substitute funding procedure or interest rate or
       rates pursuant to Clause 8.5.3 and for so long as such funding procedure
       or interest rate or rates continue(s) to be applicable, give to the Agent
       not less than five Business Days' notice (which shall be irrevocable) of
       its intention to prepay the whole (but not part only) of the Advance
       affected, in which event the Borrower shall pay:-

       (a)    on the date specified in such notice to the Agent for the account
              of the Lenders the principal amount of the Advance affected
              together with interest accrued thereon at the applicable rate to
              the date of actual prepayment; and

       (b)    to each Lender on demand such amount (if any) as such Lender may
              certify should be paid to it pursuant to Clause 26.1 (General
              Indemnity and Breakage Costs).

9.     PAYMENTS

9.1    Place and Time

9.1.1  All payments to be made by any Obligor or any Lender under the Finance
       Documents are to be made in full, without any deduction or withholding
       for or on account of any Taxes, to the Agent not later than 11.00 a.m. on
       the due date therefor to such account as the Agent specifies by written
       notice for this purpose, in immediately available and freely transferable
       Same Day Funds in the relevant currency.

9.1.2  Subject to Clause 9.1.3, each payment received by the Agent pursuant to
       Clause 9.1.1 for the account of another person will be made available by
       the Agent to that person for value on the same day by transfer to such
       bank account as that person has previously notified to the Agent by not
       less than three Business Days' prior notice.


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9.1.3  Where a sum is to be paid under the Finance Documents for the account of
       another person, the Agent will not be obliged to make any such sum
       available to that person until it has been able to establish to its
       satisfaction that it has actually received such sum, but shall be free to
       do so and if it does so and it proves to be the case that it has not
       actually received the sum it paid out, then such person will on request
       ensure that the amount so made available is refunded to the Agent and
       such person shall be liable (1) to pay to the Agent interest on the
       amount in question at the rate determined by the Agent to be equal to the
       cost to the Agent of funding such amount for the period from payment out
       by the Agent until refund to the Agent thereof and (2) to indemnify the
       Agent against any additional cost or loss it may have suffered or
       incurred by reason of it having paid out such sum prior to it having
       received the same.

9.2    No Deductions

       All payments made by any Obligor under the Finance Documents (whether of
       principal, interest, acceptance commission, fees or otherwise) shall be
       paid in full without set-off or counterclaim and not subject to any
       condition.

9.3    Taxes

9.3.1  All payments by the Obligors under the Finance Documents are to be made
       in full without any deduction or withholding for or on account of any
       Taxes unless the deduction or withholding is required by law in which
       event the relevant Obligor Borrower will:-

       (a)    ensure that the deduction or withholding does not exceed the
              minimum amount legally required;

       (b)    pay to the relevant Taxation or other authorities within the
              period for payment permitted by the applicable law such amount as
              is required to be paid in consequence of the deduction (including,
              but without prejudice to the generality of the foregoing, the full
              amount of any deduction from any additional amount paid pursuant
              to Clause 9.3.2); and

       (c)    deliver to the relevant Finance Parties within 30 days from the
              date on which the payment of such withholding tax or deduction was
              due, the documents evidencing the payment of such aforementioned
              withholding tax or deductions; and


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       (d)    indemnify each of the Finance Parties against any losses or costs
              incurred by it by reason of (i) any failure on the part of such
              Obligor to make any deduction or withholding or (ii) any such
              additional amount not being paid on the due date for payment
              thereof.

9.3.2  Subject to Clause 9.3.3, if any deduction or withholding for or on
       account of Taxes or any other deduction from any payments made or to be
       made by the relevant Obligor, or by the Agent to any other Finance Party,
       under any of the Finance Documents is required by law, then the Obligor
       shall pay to the Finance Party concerned an additional amount being the
       amount required to procure that the aggregate net amount received by that
       Finance Party will equal the full amount which would have been received
       by it had no such deduction or withholding or other deduction been made.

9.3.3  No additional amount will be payable to a Lender under Clause 9.3.2 in
       respect of Taxes to the extent that such additional amount becomes
       payable as a result only of (i) a Lender not having been a Qualifying
       Lender at the time it became a Lender, or (ii) a Lender having ceased to
       be a Qualifying Lender by any action on its part, or (iii) a change in
       the Lending Office of the relevant Lender, unless (A) such change is
       requested by the Borrower, or (B) under the relevant Tax laws,
       regulations, treaties or rules in effect at the time of the change in
       Lending Office, such additional amount would not have been payable.

9.3.4  If the Borrower is obliged to pay an amount under Clause 9.3.1, the
       Borrower may prepay in whole (but not in part) and without penalty
       (subject to Clause 27) all Advances made available to it by the affected
       Lender, upon the Borrower giving not less than three Business Days' prior
       written notice to the Agent and the affected Lender, provided that such
       notice is given within 30 days of the Borrower becoming aware that it
       would be obliged to pay such amount. The liability of such Lender to make
       any further Advances or other extensions of credit available to the
       Borrower (and such lender's Commitments) shall automatically be cancelled
       on the giving of such notice.

9.3.5  If any of the Lenders determines, in its absolute discretion, that it has
       received, realised, utilised and retained a Tax benefit by reason of any
       deduction or withholding in respect of which an Obligor has made an
       increased payment or paid any indemnifying amount or 


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       compensating sum under this Clause 9.3, such Lender shall, provided that
       the Agent and each Lender has received all amounts which are then due and
       payable by an Obligor under any of the Finance Documents, promptly pay to
       the Borrower (to the extent that such Lender can do so without
       prejudicing the amount of such benefit or repayment and the right of such
       Lender to obtain any other benefit, relief or allowance which may be
       available to it) such amount, if any, as such Lender, in its absolute
       discretion shall determine will leave such Lender in no worse position
       than it would have been in if the deduction or withholding had not been
       required, provided that:-

       (a)    each Lender shall have an absolute discretion as to the time at
              which and the order and manner in which it realises or utilises
              any Tax benefit and shall not be obliged to arrange its business
              or its Tax affairs in any particular way in order to be eligible
              for any credit or refund or similar benefit;

       (b)    no Lender shall be obliged to disclose any information regarding
              its business, Tax affairs or Tax computations;

       (c)    if a Lender has made a payment to the Borrower pursuant to this
              Clause 9.3.5 on account of any Tax benefit and it subsequently
              transpires that such Lender did not receive that Tax benefit, or
              received a lesser Tax benefit, the Borrower shall, on demand, pay
              to such Lender such sum as the relevant Lender may determine as
              being necessary to restore its after-Tax position to that which it
              would have been had no adjustment under this Clause 9.3.5 been
              necessary; and

       (d)    no Lender shall be obliged to make any payment under this Clause
              9.3.5 if, by doing so, it would contravene the terms of any
              applicable law or any notice, direction or requirement of any
              governmental or regulatory authority (whether or not having the
              force of law).

9.4    Payments on Business Days

       Subject to Clauses 6.2 and 8.3.2, if any sum would otherwise become due
       for payment pursuant to any of the Finance Documents on a day which is
       not a Business Day, such sum shall become due on the next succeeding
       Business Day unless that day falls in the next calendar month, in 


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       which case the sum shall become due on the preceding Business Day and all
       sums payable under any of the Finance Documents calculated by reference
       to any period of time shall be recalculated on the basis of such
       extension in time (or reduction thereof).

9.5    Accounts

9.5.1  Each Lender shall maintain an account or accounts recording the amounts
       from time to time lent by, owing to and paid to such Lender pursuant to
       the Finance Documents, which shall, as between such Lender and the
       relevant Obligor, be prima facie evidence of such amounts.

9.5.2  The Agent will maintain a memorandum account showing the principal amount
       of all Advances for the time being outstanding hereunder and all payments
       with respect thereto made by the Obligors from time to time pursuant to
       this Agreement.

9.6    Currency

9.6.1  A repayment or prepayment of an Advance or any part of an Advance is
       payable in the currency in which the Advance was denominated on the date
       it was made.

9.6.2  Interest and fees in respect of an Advance are payable in the currency in
       which the relevant amount of the relevant Advance in respect of which it
       is payable is denominated. Fees in respect of Commitments hereunder shall
       be payable in GBP.

9.6.3  Amounts payable in respect of costs, expenses and Taxes and the like are
       payable in the currency in which they are incurred.

9.6.4  Any other amount payable under this Agreement is, except as otherwise
       provided in this Agreement, payable in GBP.

10.    CHANGE IN CIRCUMSTANCES

10.1   Increased Costs

10.1.1 If the effect of any implementation of, change in or introduction or
       making after the date of this Agreement of, any law, regulation, treaty
       or official directive or official request or guidance applicable to any
       Lender or any affiliate, including without limitation, a holding company,
       (an "Affected Lender") (whether or not having 


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       the force of law) or any change in the interpretation or application
       thereof or compliance by such Affected Lender, with the same (including
       without limitation those relating to Taxation, reserve asset, special
       deposit, cash ratio, liquidity or capital adequacy requirements or any
       other form of banking or monetary controls) is to:-

       (a)    impose an additional cost on the Affected Lender as a result of it
              having entered into any of the Finance Documents or making or
              maintaining its participation in any Advance or of it performing
              its obligations under the Finance Documents; or

       (b)    reduce any amount received or receivable by the Affected Lender
              under the Finance Documents or reduce the effective return on its
              capital or any class thereof; or

       (c)    result in the Affected Lender making any payment or foregoing any
              interest or other return on or calculated by reference to any
              amount received or receivable by the Affected Lender from any
              other party under any of the Finance Documents,

       each such increased cost, reduction, payment, foregone interest or other
       return being hereafter referred to in this Clause 10.1 as an "increased
       cost"), then:-

(1)    the Affected Lender will notify the Borrower and the Agent of such event
       promptly upon its becoming aware of the same; and

(2)    upon demand from time to time by the Affected Lender, the Borrower will
       pay to the Affected Lender such amount as the Affected Lender shall
       determine to be necessary to compensate the Affected Lender on an
       after-tax basis for such increased cost (or the portion of such increased
       cost as is in the reasonable opinion of the Affected Lender attributable
       to its entering into the Finance Documents or of making or maintaining
       its participation in any Advance or of maintaining its Commitment).

10.1.2 The certificate of an Affected Lender specifying the amount of
       compensation payable under Clause 10.1.1 and containing reasonable detail
       as to how such amount was calculated will, in the absence of manifest
       error, be conclusive.

10.1.3 The Borrower will not be obliged to compensate any Affected Lender
       pursuant to Clause 10.1.1 in respect of any increased cost:-


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(a)    attributable to a change in the rate of Tax on the overall net income of
       the Affected Lender; or

(b)    compensated for by the operation of Clause 9.3 (Taxes); or

(c)    incurred in consequence of the implementation in whole or in part of the
       International Convergence of Capital Measurements and Capital Standards
       dated July 1988 published by the Basle Committee on Banking Regulations
       and Supervisory Practices (the "Guidance"), except to the extent that a
       higher level of capital adequacy is imposed than that stipulated in the
       Guidance as at the date of this Agreement;

(d)    including within the definition of Mandatory Liquid Asset Costs; or

(e)    until the calculation of such cost set forth in the certificate referred
       to in Clause 10.1.2 has been received by the Borrower.

10.2   Illegality

       If the effect of any implementation of, change in, or introduction or
       making after the date of this Agreement of, any law, regulation, treaty
       or official directive or official request or guidance applicable to any
       Lender or any affiliate, including without limitation, a holding company,
       (a "Restricted Lender") (whether or not having the force of law) in any
       jurisdiction applicable to such Restricted Lender is to prohibit such
       Restricted Lender, or make it illegal for such Restricted Lender, to make
       available or to maintain its participation in any Advance or maintain its
       Commitment, then such Restricted Lender will give written notice to that
       effect to the Agent and the Borrower, specifying in reasonable detail the
       obligations the performance of which is prohibited and the relevant law,
       regulation, treaty, directive, request or guideline, whereupon:-

       (a)    to the extent of such prohibition or illegality, the Borrower
              shall forthwith prepay the Restricted Lender's participation in
              all Advances then outstanding together with all interest accrued
              thereon and all other amounts due to the Restricted Lender under
              this Agreement (including pursuant to Clause 26 (Indemnities));
              and/or


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       (b)    to the extent of such prohibition or illegality, the Restricted
              Lender's undrawn Commitment (if any) shall be cancelled forthwith.

10.3   Mitigation

       If circumstances arise in relation to a particular Lender which would, or
       may, result in:-

       (a)    an obligation to pay an additional amount under Clause 9.3.2
              (Gross-Up); or

       (b)    a demand for compensation pursuant to Clause 10.1 (Increased
              Costs); or

       (c)    an obligation to repay or the cancellation of an undrawn
              Commitment under Clause 10.2 (Illegality);

       then, without in any way limiting, reducing or otherwise qualifying the
       obligations of the Borrower under any of the Clauses referred to above,
       such Lender will promptly after becoming aware thereof notify the Agent
       and the Borrower thereof and, except as set out in the provisos in
       paragraphs (y) and (z) below, in consultation with the Agent and the
       Borrower, take such steps as may be reasonably open to it to mitigate the
       effects of such circumstances including (but without limitation):-

(i)    changing its Lending Office for the purposes of this Agreement; or

(ii)   transferring its rights and obligations hereunder pursuant to Clause 25.2
       or 25.3 to a bank or financial institution acceptable to the Borrower and
       the Agent which is willing to participate in the Facilities in its place;

       provided that (y) the Lender concerned will not be obliged to take any
       action under sub-paragraph (i) above if to do so would or might (in its
       opinion) have an adverse effect upon its business, operations or
       financial condition or cause it to incur liabilities (including any
       material costs and expenses) or obligations (including Taxation) which
       (in its opinion) are material or would reduce its return in relation to
       its participation in the Facilities and (z) such Lender will not be
       obliged to take the action referred to in sub-paragraph (ii) above unless
       the Borrower indemnifies it by means of an indemnity in form and content
       satisfactory to such Lender against any liabilities or obligations
       reasonably incurred as a result of taking such action.


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11.    FEES, EXPENSES AND STAMP DUTIES

11.1   Fees

11.1.1 The Borrower will pay to the Agent the following fees:-

(a)    for the account of each Lender a commitment fee during the Availability
       Period for each respective Facility which will:-

(i)    be computed at a rate per annum equal at all times to one-half of the
       Margin and on the daily aggregate undrawn, uncancelled amount of the
       Total Commitments;

(ii)   accrue from day to day and be calculated on the basis of a 365 day year
       and the actual number of days elapsed;

(iii)  be payable quarterly in arrears on the last day of each successive
       calendar quarter, on each drawing under the Tranche A Term Facility and
       on the termination or lapse of the Availability Period to the extent no
       drawing under the Tranche A Term Facility is made concurrent with such
       termination or lapse; and

(b)    for its own account or as otherwise specified in the Fees Letter, such
       arrangement, agency and other fees at the times and otherwise in
       accordance with the terms of the Fees Letter.

11.1.2 All fees payable under the Finance Documents are exclusive of any VAT or
       other similar tax chargeable upon or in connection with such fees. If any
       VAT or other similar Tax is or becomes so chargeable, such Tax will be
       paid by the Borrower at the same time as the relevant fee itself is paid.

11.1.3 The Borrower authorises the Agent to discharge the fees due upon Initial
       Drawdown under Clauses 11.1.1 (a) and (b) from the proceeds of Advances
       made upon Initial Drawdown under any Facility.

11.2   Expenses

11.2.1 The Borrower will (subject to the limitations set forth in the Fees
       Letter) on demand pay and reimburse to the Agent and the Security Agent,
       on the basis of a full indemnity, all reasonable costs and expenses
       (including legal fees, due diligence expenses, recordation fees and other
       out-of-pocket expenses and any VAT or other similar Tax thereon) incurred
       by the Agent or the Security Agent 


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       in connection with the negotiation, preparation, recordation, execution
       and completion of each of the Finance Documents, and all documents,
       matters and things referred to in the Finance Documents or incidental to
       any of the Finance Documents.

11.2.2 The Borrower will on demand pay and reimburse to the Agent and the
       Security Agent, on the basis of a full indemnity, all reasonable costs
       and expenses (including reasonable legal fees, recordation fees and other
       out-of-pocket expenses and any VAT or other similar Tax thereon) incurred
       by the Agent or the Security Agent in connection with:-

(a)    any variation, recordation, amendment, supplement, restatement, waiver,
       consent or suspension of rights (or any proposal for any of the same)
       relating to any of the Finance Documents (and documents, matters or
       things referred to therein); and

(b)    the investigation of any Event of Default or Potential Event of Default,
       provided that the relevant Finance Party had reasonable grounds to
       believe that such Event of Default or Potential Event of Default had
       occurred.

11.2.3 The Borrower will on demand pay and reimburse to each Finance Party, on
       the basis of a full indemnity, all costs and expenses (including
       reasonable legal fees, recordation fees and other out-of-pocket expenses
       and any VAT or other similar Tax thereon) incurred by such Finance Party
       in connection with the preservation, enforcement or the attempted
       preservation or enforcement of any Finance Document or of such Finance
       Party's rights under any of the Finance Documents (and documents referred
       to therein).

11.3   Stamp Duties, etc.

       The Borrower will:-

       (a)    pay, and on demand indemnify each Finance Party from and against
              any liability for, any stamp duty, documentary, registration and
              other duties and Taxes (if any) which are or may hereafter become
              payable in connection with the entry into, performance,
              recordation, execution or enforcement of any of the Finance
              Documents or to which any of the Finance Documents may otherwise
              be or become subject or give rise; and


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       (b)    on demand indemnify each of the Finance Parties from and against
              any losses or liabilities which they may incur as a result of any
              delay or omission by the Borrower to pay any such duties or Taxes.

12.    REPRESENTATIONS AND WARRANTIES

12.1   Reliance and Effective Time

12.1.1 Each Obligor acknowledges that each Finance Party has or will have
       entered into this Agreement and the other Finance Documents to which it
       is a party and participated in the Advances in full reliance on
       representations in the terms set out in the following provisions of this
       Clause 12. Subject to Clause 12.1.2, each Obligor represents and warrants
       to each Finance Party in the terms set forth in Clauses 12.2 to 12.23
       inclusive with reference to itself and, where appropriate, its
       subsidiaries.

12.1.2 The representations and warranties in this Clause 12 will be deemed
       initially made on the date of this Agreement and repeated on the date of
       delivery of each Drawdown Request, on each Drawdown Date and on each
       Interest Payment Date thereafter by reference to the facts and
       circumstances existing on each such day, except that:

(a)    each reference to financial statements in Clause 12 shall be construed as
       a reference to the then latest available financial statements of the
       relevant Obligor; and

(b)    those representations and warranties which are expressly stated to relate
       to an earlier date or time shall be deemed repeated only by reference to
       the facts and circumstances existing at that earlier date or time.

12.2   Incorporation

       It is duly incorporated or organised and validly existing with limited
       liability under the laws of the country or other jurisdiction of its
       incorporation or organisation, and has the power to own its assets and
       carry on its business as it is being conducted or is proposed to be
       conducted.

12.3   Power and Authority

       It has all necessary power and authority to enter into and perform all
       its obligations under the Finance Documents to which it is expressed to
       be a party, has 


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       taken all necessary action to authorise the execution (if appropriate,
       under seal or as a deed), delivery and performance by it of each Finance
       Document and other document referred to therein to which it is expressed
       to be a party or signatory, and (in the case of the Borrower only) has
       taken all necessary action to authorise the borrowings by it under this
       Agreement.

12.4   No Contravention

12.4.1 The execution, delivery and performance of the Finance Documents to which
       it is a party is not now and will not:-

       (a)    violate, conflict with, or cause a breach or default under, its
              organisational documents, any provision of any existing law,
              regulation, statute, judgement, decree, order, license, permit or
              consent applicable to it or its assets or of any agreement,
              mortgage, contract, instrument or other undertaking to which it is
              party, which is binding upon it or under which it or any of its
              assets may be bound or affected; or

       (b)    will not oblige it to create any Security Interest over all or any
              of its assets other than any Security Interest under the Security
              Documents.

12.4.2 Borrowings by the Borrower under this Agreement up to and including the
       maximum amount available hereunder will not cause any limit on borrowings
       (whether imposed by statue, regulation, agreement or otherwise), or on
       the powers of its board of directors, to be exceeded.

12.5   Authorisations and Consents

       All consents, licenses, approvals, authorisations and notifications
       (whether corporate, official or otherwise) required to be obtained or
       made by it in connection with the entry into, validity, performance and
       enforceability of each of the Finance Documents to which it is a party
       have been unconditionally obtained and are in full force and effect.

12.6   Enforceability; Ranking

       Its obligations under the Finance Documents to which it is a party
       constitute its legal, valid, binding and enforceable obligations and are
       in full force and effect, except (in the case of enforceability) as
       limited by the Reservations, and such obligations, to the extent not
       secured by any Security Interest, ranks and will continue 


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       to rank at all times at least pari passu with all its unsecured and
       unsubordinated obligations (subject to the preference of certain
       obligations in the liquidation, bankruptcy or other analogous proceedings
       in respect of it by mandatory operation of applicable law).

12.7   Litigation

       It is not involved in any pending or, to the best of its knowledge,
       threatened litigation, arbitration or administrative proceeding, nor is
       there subsisting any unsatisfied judgement or award given against it by
       any court, board of arbitration or other body, which is reasonably likely
       to result in liability to any Obligor which has or is reasonably likely
       to have a Material Adverse Effect.

12.8   Accounts

12.8.1 The consolidated or unconsolidated financial statements of each Obligor
       most recently delivered to the Agent pursuant to Clause 4.1.1 or 13.3, as
       the case may be, including any notes thereto:-

(a)    have been prepared in accordance with the respective relevant Approved
       Accounting Principles consistently applied, except to the extent
       specified therein; and

(b)    give a true and fair view of the consolidated or unconsolidated (as the
       case may be) financial condition of the relevant persons as at the
       respective dates to which they were drawn up;

       and in each case set forth all material actual or contingent liabilities
       then existing required to be set forth therein in accordance with the
       relevant Approved Accounting Principles consistently applied subject in
       the case of any unaudited interim financial statements, to changes
       resulting from normal year-end audit and other adjustments.

12.9   No Material Adverse Effect

       No event or matter having or likely to have a Material Adverse Effect has
       occurred since 31st December, 1996.

12.10  Security Interests

       Except as permitted by Clause 13.2.10, no Security Interest exists on the
       date of this Agreement on the 


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       undertaking, property or assets, present or future, of the Borrower or
       any of its subsidiaries.

12.11  No Defaults

       Unless notified to the Agent under Clause 13.3.1, no Event of Default or
       Potential Event of Default has occurred and is continuing and no event
       has occurred (which has not been remedied or waived) which constitutes a
       default under or in respect of any agreement, instrument, deed or
       document to which it is a party or by which it or any of its assets may
       be bound or affected being a default which has or is reasonably likely to
       have a Material Adverse Effect, and no event has occurred (which has not
       been remedied or waived) which, with the giving of notice which may
       validly be given and/or the lapse of any grace period and/or giving of
       any certificate or statement which may validly be given and/or making of
       any determination which may validly be made and/or fulfilment of any
       other condition (which notice, grace period, certificate, statement,
       determination or condition is in any case specified or referred to in the
       relevant agreement, instrument, deed or document), will constitute any
       such default which is reasonably likely to have a Material Adverse
       Effect.

12.12  Compliance with Laws

       It is in compliance with all laws, regulations, statutes, judgements,
       orders, licenses, permits or consents applicable to it or its assets,
       except any non-compliance which does not have and is not reasonably
       likely to have a Material Adverse Effect.

12.13  Ownership of Assets, Licenses and Agreements for Business Operations;
       Intellectual Property

12.13.1  It has good (and in the case of Scottish property, valid and
         marketable) title to, or valid leasehold or other valid right to use,
         all its material assets (including without limitation those relating to
         the Annan Facility and the Dudley Facility) to the extent required to
         conduct the Business or the part thereof which it conducts.

12.13.2  All licenses, consents and authorisations (including without
         limitation, all such licenses, consents and authorisations required to
         be obtained from the United States Food and Drug Administration, the
         Medicines Control Agency and any other regulatory body having
         jurisdiction over the manufacture and/or


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         sale of pharmaceutical products in the United States or the United
         Kingdom) have been obtained which are necessary for the carrying on of
         its Business or the part thereof which it conducts, and all such
         licenses, consents and authorisations are in full force and effect, and
         there are no circumstances known to it which indicate that any of such
         licenses, consents and authorisations is reasonably likely to be
         revoked or varied or amended in whole or in part, except to the extent
         that the absence, non-effectiveness, revocation, variation or amendment
         of any such license, consent or authorisation would not have and would
         not be reasonably likely to have a Material Adverse Effect.

12.13.3  The Obligors own or have licensed to them all Intellectual Property
         rights required to conduct the Business, and the Intellectual
         Property:-

         (a)      is beneficially owned by or validly licensed to an Obligor,
                  is, to the best knowledge of the Obligors, free from any
                  licenses to third parties and Security Interests, and will not
                  be adversely affected by the transactions contemplated by this
                  Agreement;

         (b)      has not lapsed or been cancelled and all steps have been taken
                  to protect and maintain the Intellectual Property including
                  paying renewal fees where appropriate; and

         (c)      does not, to the best knowledge of any Obligor, infringe any
                  intellectual property rights of any nature of any third party.

12.13.4  ChiRex (Annan) Limited has made appropriate provision for an
         operationally and economically viable source of water supply for the
         needs of the Business currently conducted, or anticipated, at the Annan
         Facility.

12.14    Tax Liabilities

         No claims are being or are reasonably likely to be asserted against it
         with respect to Taxes which would be reasonably likely to have a
         Material Adverse Effect.

12.15    Solvency

12.15.1  As at the Initial Drawdown Date, immediately prior to each Drawdown, it
         will be solvent within the 


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         definition of any law applicable to it which requires as a condition to
         the validity (and/or non-avoidability) of financial obligations
         undertaking by it that it be solvent.

12.15.2  It has not taken any action nor (so far as it is aware having made all
         due enquiry) have any steps been taken or legal proceedings been
         started against it for winding-up, dissolution or re-organisation, the
         enforcement of any Security Interest over its assets or for the
         appointment of a receiver, administrative receiver, or administrator,
         trustee, judicial factor, manager for credits, or similar officer of it
         or of any or all of its assets or any other procedure under which it
         obtains protection from any of its creditors, or any analogous
         proceedings in any relevant jurisdiction.

12.16    Group Structure

         The structure of the ChiRex Group as at the Initial Drawdown Date is as
         set out in Schedule 4.

12.17    Indebtedness

         The Obligors have no Financial Indebtedness as of the date of this
         Agreement other than as set forth in subclause (iii) of the definition
         of Permitted Indebtedness.

12.18    Margin Stock

         Neither it, nor any of its subsidiaries, is engaged principally, or as
         one of its important activities, in the business of extending credit
         for the purpose of purchasing or carrying any Margin Stock and none of
         the proceeds of the facilities made available hereunder will be used,
         directly or indirectly, to purchase or convey any Margin Stock or to
         extend credit to others for the purchasing or conveying of any Margin
         Stock.

12.18.1  Accountants' Report; Industry Report; Business Plan; Operating Budget

         In relation to the Accountants' Report:-

         (a)      all factual information contained in the Accountants' Report
                  was, at the date of the report, true and accurate in all
                  material respects; and


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         (b)      all assumptions and presumptions contained in the Accountants'
                  Report (on the consolidated basis contemplated in the
                  Accountants' Report) attributable to the ChiRex Group were
                  reasonable at the time they were made and in relation to the
                  period in respect of which they were made.

         In relation to the Industry Report:-

         (c)      all factual information contained in the Industry Report was,
                  at the date of the report, true and accurate in all material
                  respects; and

         (d)      all assumptions and presumptions contained in the Industry
                  Report (on the consolidated basis contemplated in the Industry
                  Report) attributable to the ChiRex Group were reasonable at
                  the time they were made and in relation to the period in
                  respect of which they were made.

         In relation to the Business Plan and the Operating Budget:

         (e)      all factual information contained in or utilised for the
                  purpose thereof was, at the date thereof, true and accurate in
                  all material respects and nothing has occurred since the date
                  thereof which renders any factual statement contained therein
                  or so utilised misleading in any material respect;

         (f)      all assumptions and presumptions made for the purpose thereof
                  were fair and reasonable at the time they were made and in
                  relation to the period in respect of which they were made and
                  so far as the ChiRex Group is aware (after having made all due
                  enquiry) nothing has occurred since the date thereof which
                  makes it necessary to change the consolidated forecasts,
                  projections and estimates set out therein in any material
                  respect; and

         (g)      all forecasts, projections and estimates taken on a
                  consolidated basis contained or referred to in the Operating
                  Budget and all assumptions and presumptions upon the basis of
                  which the same were made, at the time they were made were, to
                  its best knowledge, fair and reasonable and, so far as the
                  ChiRex Group is aware (after having made all due enquiry),
                  nothing has occurred since the date thereof which makes it
                  necessary to change any of those forecasts, projections and
                  estimates in any material respect.


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12.19    Environmental Report

         In relation to the Environmental Report, (a) to the best knowledge of
         the Borrower after due inquiry all factual information contained in the
         Environmental Report was, at the date of such report, true and accurate
         in all material respects and nothing has occurred since the date of
         such report which renders any factual statement therein misleading in
         any material respect, and (b) all forecasts, projections and estimates
         contained or referred to in the Environmental Report and all
         assumptions and presumptions upon the basis of which the same were
         made, at the time they were made were fair and reasonable and, so far
         as the Borrower is aware (after having made all due enquiry), nothing
         has occurred since the date thereof which makes it necessary to change
         any of those forecasts, projections and estimates in any material
         respect.

12.20    Environmental Warranties

12.20.1  To the best knowledge of each Obligor, no Environmental Event has
         occurred at any time in relation to any site now or previously owned,
         operated or occupied by the Borrower, any Guarantor or any of their
         respective subsidiaries (or with respect to which any of them could be
         subject to an Environmental Claim) which individually or in the
         aggregate could reasonably be expected to have a Material Adverse
         Effect.

12.20.2  It has obtained and is, and has at all times been, in substantial
         compliance with all Environmental Licenses necessary in connection with
         the ownership and operation of its facilities and business as currently
         owned and operated or if there is or has been any failure to so obtain
         or any non-compliance with such Environmental Licenses such failure or
         non-compliance, individually or in the aggregate could not reasonably
         be expected to have a Material Adverse Effect.

12.20.3  No circumstances exist which could reasonably be expected to prevent or
         interfere with any Obligor or any of their respective subsidiaries
         obtaining or being in substantial compliance with any Environmental
         Licenses in the future so as to give rise to a Material Adverse Effect.


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12.20.4  On the basis of its ongoing reviews which identify and evaluate
         liabilities and costs relating to Environmental Law, it has reasonably
         concluded that the application of any Environmental Law to it or any of
         its subsidiaries could not reasonably be expected to have a Material
         Adverse Effect.

12.20.5  Its operations, and the operations of its subsidiaries, are, and at all
         times have been, in full compliance with all Environmental Law or if
         there is any non-compliance with Environmental Laws, such
         non-compliance could not reasonably be expected to have a Material
         Adverse Effect. No circumstances exist which currently are known or
         ought reasonably to be known by it which may reasonably be expected to
         prevent or interfere with any Obligor or any of their respective
         subsidiaries being in full compliance with any Environmental Laws in
         the future so as to give rise to a Material Adverse Effect.

12.21    Labour Law and Employee Benefit Plans

         It has complied with all applicable labour and social security laws and
         instituted all employee benefit plans legally necessary; these plans in
         place are in full force and effect and each such plan is fully funded
         to meet its expected obligations as they come due except for such
         failure to fund, the liability as to which is not reasonably likely to
         have a Material Adverse Effect.

12.22    U.S. Employee Benefit Plans.

         (a)      As at the date of this Agreement no US Obligor has a
                  "multiemployer plan" (as defined in the definition of Employee
                  Benefit Plan) and no Employee Benefit Plan of any US Obligor
                  is subject to Title IV of ERISA.

         (b)      Each Employee Benefit Plan is in compliance in form and
                  operation and in all other material respects with the
                  applicable provisions of ERISA, the Code and any other
                  applicable Federal or U.S. state law, and no event or
                  condition has occurred or exists concerning such Employee
                  Benefit Plan which any US Obligor or any ERISA Affiliate
                  thereof would be under an obligation to report to the Agent in
                  accordance with Clause 13.3.8(e).

12.23    U.K. Employee Benefit Plans.


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         (a)      No agreement or arrangement (other than the Scheme) exists for
                  the provision by any Obligor of any relevant benefits (as
                  defined in Section 612 of the ICTA) for any person or (without
                  limitation to the foregoing) superannuation benefits for
                  employees.

         (b)      The last actuarial valuation of the Scheme disclosed that the
                  aggregate value of the assets of the Scheme at the date of the
                  valuation was equal to or greater than the aggregate value of
                  the liabilities of the Scheme on an on-going basis calculated
                  in accordance with the actuarial methods and assumptions used
                  in the valuation. So far as the Obligors are aware, no event
                  has occurred since the valuation that would have materially
                  adversely affected the funding position of the Scheme.

         (c)      Except that no action has been taken under the Scheme to
                  eliminate discriminatory treatment as between men and women
                  which is attributable to the provision of guaranteed minimum
                  pensions (within the meaning of the Pension Schemes Act 1993),
                  the applicable Obligors have complied in all material respects
                  with their respective obligations under the Scheme in relation
                  to past and present employees and officers of such Obligors
                  and all material amounts due to be paid to the Scheme from
                  such Obligors have been paid.

         (d)      No undertaking or assurance has been given to any member of
                  the Scheme as to continuance, introduction, increase or
                  improvement of any benefits under the Scheme.

         (e)      To the best knowledge of the Obligors, there are not in
                  respect of the Scheme any claims or actions pending or
                  threatened involving any Obligor or the trustees of the Scheme
                  (other than routine claims for benefits).

         (f)      No Obligor is providing, or, upon the consummation of the Sale
                  and Purchase Agreement, will be obligated to provide, material
                  ex gratia pension or other similar payments for any former
                  employee.


         (g)      No company other than the applicable Obligor participates or
                  has participated in the Scheme.

12.24    Governmental Regulation


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          It is not subject to regulation under the Public Utility Holding
          Company Act of 1935, the Federal Power Act, the Interstate Commerce
          Act or the Investment Company Act of 1940 or under any other federal
          or state statute or regulation which may limit its ability to incur
          Financial Indebtedness or which may otherwise render all or any
          portion of the obligations under the Finance Documents unenforceable.

13.       UNDERTAKINGS

13.1      Duration

          Each Obligor undertakes to each of the Finance Parties in the terms of
          the provisions of Clauses 13.2 to 13.4 (inclusive), and ChiRex Inc.
          undertakes to each of the Finance Parties in terms of the provisions
          of Clause 13.5, all such undertakings to continue until the
          liabilities and obligations under each of the Finance Documents have
          been finally discharged and no Finance Party has any obligation to
          lend hereunder, unless in any case the Agent (acting on the
          instructions of the Majority Lenders) agrees otherwise. All
          undertakings set forth in this Clause 13 are cumulative such that, if
          more than one set of such undertakings are given by an Obligor, such
          Obligor shall be bound by the aggregate of all restrictions set forth
          in the undertakings given by it.

13.2      General Undertakings

13.2.1    Use of Proceeds

          It will procure that the proceeds of Advances be used only for the
          purposes specified in Clause 2.2.

3.2.2     Authorisations and Consents

          It will, and will procure that each of its subsidiaries will, obtain
          and promptly renew from time to time and maintain in full force and
          effect all such authorisations, approvals, consents, licenses and
          exemptions, and promptly make and renew from time to time all such
          filings and registrations, as may be required under any applicable law
          or regulation (i) to enable it to perform its obligations under each
          of the Finance Documents and (ii) for the validity and enforceability
          thereof, subject to the Reservations.

13.2.3    Change of Business


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          It will not, and will procure that each of its subsidiaries will not,
          engage in any material business other than the Business or any
          business reasonably incidental thereto.

13.2.4    Maintenance of Status and Authorisations, Title to Assets

          It will, and will procure that each of its subsidiaries will:-

          (a)       do all such things as are necessary to maintain their
                    respective legal existences, except that any two or more
                    subsidiaries of an Obligor may consolidate or merge with one
                    another, in each case in accordance with Clause 13.2.9;

          (b)       ensure that it and each of them has the right and is duly
                    qualified to conduct their respective businesses as
                    conducted in all applicable jurisdictions, and obtain and
                    maintain all licenses, consents, authorisations, franchises,
                    Intellectual Property and other rights necessary for the
                    preservation and operation of such businesses in all
                    material respects, except to the extent that the absence of
                    any such right or qualification, or the non-existence or
                    non-maintenance of such licenses, consents, authorisations,
                    franchises, property or rights would not be reasonably
                    likely to have a Material Adverse Effect; and

          (c)       comply in all material respects with all laws, regulations,
                    judgements, decrees, orders, licenses, permits or consents
                    binding upon it, except where non-compliance would not be
                    reasonably likely to have a Material Adverse Effect.

13.2.5    Arm's Length Transactions

          It will not enter into, and will procure that each of its subsidiaries
          does not enter into, any arrangement or transaction other than (i) on
          an arm's length basis and for at least market value, or (ii) on terms
          that in every respect are equal to or more advantageous to such
          Obligor.

13.2.6    Insurances

          It will:-


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          (a)       maintain and will procure that each of its subsidiaries
                    maintains in full force and effect adequate insurance
                    (including, without limitation, employer's and public
                    liability insurance and business interruption/loss of
                    profits insurance) in relation to its and their respective
                    assets and businesses against all such risks as are normally
                    insured against by other companies (whose practice is not to
                    self-insure except in connection with reasonable excesses)
                    owning or possessing similar assets or carrying on similar
                    businesses in an amount, to the extent reasonably possible,
                    equal to the full replacement cost of such assets (after
                    allowing for any decrease in value of such assets as a
                    result of normal wear and tear in the case of plant and
                    machinery and related assets), in respect of its or their
                    respective businesses, except where its failure to do so
                    would not be reasonably likely to have a Material Adverse
                    Effect;

          (b)       procure that the interest of the Security Agent is noted on
                    all policies of such insurance (or at the option of the
                    Security Agent, acting reasonably, and where the relevant
                    insurer agrees, that such policies are issued in the joint
                    names of the Security Agent and the relevant Obligor); and

          (c)       if so requested by the Agent, supply copies of all such
                    policies, and receipts for all premiums and other payments
                    necessary for effecting and keeping such policies.

13.2.7    Taxes

          It will pay within any permitted period, and will procure that each of
          its subsidiaries pays within any permitted period, all material Taxes
          imposed upon it or any of them or any of its or their assets, income
          or profits or any transactions undertaken or entered into by it or any
          of them (other than such Taxes as are being contested in good faith by
          appropriate proceedings, pending determination of which payment may
          lawfully be withheld without penalty, in respect of which Taxes there
          shall be set aside adequate reserves in accordance with the applicable
          Approved Accounting Principles).

13.2.8    Disposals

          It will not, and will procure that its subsidiaries will not (whether
          by a single transaction or a number of related or unrelated
          transactions and whether at the same


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          time or over a period of time) sell, transfer or otherwise dispose of
          any of its assets (including shares of the capital stock of any other
          person, or if such person is not an incorporated entity, other
          ownership interests therein, and the coverage of this undertaking is
          to be deemed to include any transaction the effect of which would be
          to reduce the percentage of any class of shares or interests in any
          person held directly or indirectly by such Obligor) or all or any part
          of its undertakings, assets or revenues or any interest therein, other
          than:-

          (a)       disposals of assets on an arm's length basis in the ordinary
                    course of trading;

          (b)       payment of cash in respect of a transaction not otherwise
                    prohibited by this Agreement, and exchange of cash
                    equivalents for cash;

          (c)       the exchange, or replacement within three months, of assets
                    for or with other assets required for its trading activities
                    of similar or greater value than the assets disposed of or
                    replaced, on arm's length commercial terms;

          (d)       disposals of assets which are no longer required for the
                    purposes of its business at a price not significantly less
                    than the market value of those assets less, if the assets
                    would otherwise be liquidated, the costs of the liquidation;
                    or

          (e)       disposals, other than disposals of shares or ownership
                    interests in ChiRex America Inc. or the Borrower, not
                    falling within any other paragraph of this Clause 13.2.8
                    whose consideration does not exceed GBP 5,000,000 (or its
                    equivalent) in any one Accounting Reference Period and GBP
                    15,000,000 (or its equivalent) when aggregated with all
                    other such disposals made by the Obligors and each of their
                    respective subsidiaries following the date of this
                    Agreement.

13.2.9    Merger, Consolidation, Etc.

          It will not, and will procure that its subsidiaries do not, merge or
          consolidate with any other person (whether by winding-up, dissolution
          or other means) except that:-

          (a)       two or more Tier I Guarantors may consolidate or merge with
                    one another or an Obligor which is not a


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                    Tier I Guarantor may merge into an Obligor which is a Tier I
                    Obligor, and

          (b)       any subsidiary of an Obligor may merge into such Obligor,

          provided in that the Agent shall have received legal opinions in
          respect of the relevant merger or consolidation in form and substance
          reasonably satisfactory to the Agent, which legal opinions shall, in
          any event, confirm that none of the material rights of any Finance
          Party or the material obligations and liabilities to any Finance Party
          of any Obligor will, after such merger or consolidation, cease to be
          in full force and effect and that the person surviving or resulting
          from such merger or consolidation is bound under the Finance Documents
          after giving effect to such merger or consolidation to the same extent
          as the other person or persons party to such transaction were bound
          immediately prior thereto.

13.2.10   Negative Pledge; Absence of Other Negative Pledges

          (a)       It will not, and will procure that its subsidiaries will
                    not, create or have outstanding any Security Interest on or
                    over its respective assets, other than Permitted Security
                    Interests.

          (b)       It will not, and will procure that none of its subsidiaries
                    will, covenant for the benefit of any person other than the
                    Lenders pursuant to the Finance Documents, to refrain from
                    granting for the purpose of securing Financial Indebtedness,
                    Security Interests on all or any portion of its or their
                    assets or properties, except (i) in respect of assets
                    subject to Permitted Security Interests in favour solely of
                    the holder of the relevant Security Interest and (ii) any
                    such covenants in existence on the date hereof pursuant to
                    any of the Continuing Indebtedness provided that the
                    principal amount of such Continuing Indebtedness shall not
                    be increased after the date hereof.

13.2.11   Indebtedness

          It will not, and will procure that its subsidiaries will not, incur or
          permit to exist any Financial Indebtedness other than Permitted
          Indebtedness.

13.2.12   Loans, Etc.


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          It will not, and will procure that its subsidiaries will not, make or
          permit to be outstanding any loans or grant any credit to any person
          or make any other similar arrangement other than:-

(i)       loans to directors or employees which, together with all such loans
          made by the Borrower and its subsidiaries, do not exceed a maximum
          aggregate amount of GBP 1,000,000 (or its equivalent) outstanding at
          any time;

(ii)      trade credit granted in the ordinary course of its trading business,

(iii)     loans to all material terms of which the Agent (acting upon the
          instructions of the Majority Lenders) has consented; and

(iv)      loans or credits granted by one of the Borrower's subsidiaries to the
          Borrower or another of the Borrower's subsidiaries.

13.2.13   Acquisitions of Subsidiaries or Businesses

          It will not, and will procure that its subsidiaries will not (i)
          acquire any subsidiary which is not its subsidiary as at the date of
          this Agreement, (ii) acquire any business, or (iii) enter into any
          agreement under which it may be or become bound to acquire any such
          subsidiary or business other than:-

          (a)       subsidiaries or businesses acquired exclusively with the
                    proceeds of one or more sales of equity securities or rights
                    in relation thereto, where (i) the subsidiary or business to
                    be acquired is such that it would not result in the untruth
                    or inaccuracy of any representation or warranty set forth
                    herein, the violation of any covenant set forth herein, or
                    the occurrence of any Potential Event of Default or Event of
                    Default, as demonstrated in each case to the reasonable
                    satisfaction of the Agent, (ii) if on a pro forma basis (as
                    demonstrated to the reasonable satisfaction of the Agent),
                    the proposed acquisition would result in there being a
                    Material Subsidiary which is not an Obligor, the acquiror
                    shall simultaneously with the acquisition cause compliance
                    by the acquired business or acquired subsidiary with Clause
                    13.2.22, and (iii) if the business or subsidiary proposed to
                    be acquired has any interest in real property which may
                    subject such business or subsidiary or any other member of
                    the ChiRex Group


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                    to liability under any Environmental Law, the acquiror shall
                    provide to the Agent a report of the type described in
                    Clause 13.2.18(g) in all respects satisfactory to the Agent
                    no fewer than 20 days prior to the date of the proposed
                    acquisition; and

          (b)       subsidiaries or businesses acquired in whole or in part with
                    the proceeds of Financial Indebtedness (including any direct
                    or indirect usage of the Tranche B Facility), where (i) the
                    acquisition satisfies the requirements of the preceding
                    Clause 13.2.13(a), and (ii) the Agent has received evidence
                    to its reasonable satisfaction that the proposed acquisition
                    will not result in the ChiRex Group having available to it
                    at any time insufficient cash or liquid assets to enable it
                    to meet all of the payment obligations under this Agreement
                    as well as all other material liabilities as they are then
                    anticipated to fall due.

13.2.14   Restriction on Redemption and Acquisition of Own Shares

          It will not, and will procure that none of its subsidiaries will,
          directly or indirectly redeem, purchase, retire or otherwise acquire
          for consideration any shares, warrants or other equity or equity
          related securities issued by it or set apart any sum for any such
          purpose or otherwise reduce its capital without the consent of the
          Agent (acting on the instructions of the Majority Lenders), except to
          the extent that any sums paid or set apart by ChiRex Inc. in respect
          of the redemption, purchase, retirement or acquisition of its shares,
          when added to any other Restricted Payments, do not exceed in
          aggregate the Available Amount.

13.2.15   Blockage of Payments, Etc.

          It is not, and will procure that none of its subsidiaries is, a party
          to any contractual or similar arrangement pursuant to which any such
          subsidiary is prohibited from making any loan, payment of dividends,
          distributions of income or other amounts, or transferring any
          properties or assets, to it, or any condition or requirement is
          imposed on any such payment or transfer except, in the case of
          prohibitions on transfers of properties or assets, customary
          provisions restricting subletting or assignment of any lease governing
          a leasehold interest of it or one of its subsidiaries.

13.2.16   Restriction on Payment of Dividends, Etc.


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          It will not declare or pay, directly or indirectly, any dividends or
          make any other distribution, or other amounts whether in cash or
          otherwise, on any of its ordinary or other shares except to the extent
          that dividends paid by ChiRex Inc., when added to any other Restricted
          Payments, do not exceed in aggregate the Available Amount.

13.2.17   Material Agreements

          The relevant Obligor will at its own cost and expense take all
          reasonable steps to preserve and enforce available rights and remedies
          in respect of the Material Agreements or any breach thereof, maintain
          in full force and effect (subject to rights of termination exercisable
          by the other party or parties thereto not arising from the relevant
          Obligor's actions or omissions) and during their term comply with the
          terms of the Material Agreements in all material respects, and not
          agree to any waiver of any material term of or to any material
          amendment or variation of the terms of the Material Agreements, except
          to the extent that the failure to perform or observe any of the
          undertakings set forth in this Clause 13.2.17 is not reasonably likely
          to have a Material Adverse Effect.

13.2.18   Environmental Obligations

          (a)       It will, and will procure that each of its subsidiaries
                    will, (i) comply with the terms of all Environmental
                    Licenses and Environmental Laws applicable to it or any of
                    its subsidiaries, (ii) promptly pay or cause to be paid all
                    costs and expenses incurred in such compliance and (iii)
                    keep or cause to be kept all real property now or hereafter
                    owned or operated by it or any of its subsidiaries free and
                    clear of any Security Interests imposed pursuant to such
                    Environmental Laws for such period as such real property is
                    owned or operated by it or any of its subsidiaries, except
                    for such non-compliances, failures to pay or Security
                    Interests which individually or in the aggregate could not
                    reasonably be expected to have a Material Adverse Effect.

          (b)       It shall promptly take, and shall cause each of its
                    subsidiaries promptly to take, any and all investigation,
                    study, sampling, testing, abatement, clean up, removal,
                    remediation, or other appropriate response action necessary
                    to remove, remediate,


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                    clean up, or abate any Environmental Contamination that is
                    in violation of any Environmental Laws or that presents a
                    material risk of giving rise to an Environmental Claim where
                    the failure to do is reasonably likely to have a Material
                    Adverse Effect. In the event it or any of its subsidiaries
                    undertakes any such action with respect to any Dangerous
                    Substances on, under or about any real property owned or
                    operated by any of them, it or such subsidiary shall conduct
                    and complete such action in compliance with all applicable
                    Environmental Laws, and in accordance with the policies,
                    orders and directives of all Governmental Authorities except
                    when, and only to the extent that, its or such subsidiary's
                    liability for such presence, storage, use, disposal,
                    transportation or discharge of any Dangerous Substances is
                    being contested in good faith by it or such subsidiary.

          (c)       It shall promptly take, and shall cause each of its
                    subsidiaries promptly to take, any and all action necessary
                    to cure any violation of applicable Environmental Laws by
                    such Obligor or its Subsidiaries that could reasonably be
                    expected to have, individually or in the aggregate, a
                    Material Adverse Effect.

          (d)       It will not, and will procure that each of its subsidiaries
                    will not, generate, use, treat, store, release or dispose
                    of, or permit the generation, use, treatment, storage,
                    release or disposal of Dangerous Substances on any real
                    property now or hereafter owned or operated by it or any of
                    its subsidiaries, or transport or permit the transportation
                    of Dangerous Substances to or from any such real property
                    except for Dangerous Substances used or stored at, or
                    transported from, any such real properties in compliance
                    with all applicable Environmental Laws and used in
                    connection with the operation, use and maintenance of any
                    such real property, except such non-compliances as could not
                    reasonably be expected to have a Material Adverse Effect.

          (e)       If: (i) an Event of Default has occurred and is continuing;
                    (ii) the Lenders receive notice under Clauses 13.2.18(f) or
                    13.2.18(g) for any event for which notice is required to be
                    delivered for any such real property; or (iii) the Agent or
                    the Majority Lenders reasonably believe that there was a
                    breach of any representation, warranty or covenant


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                    contained in Clause 12.20, 13.2.18(a) or 13.2.18(d); then,
                    at the written request of the Agent or the Majority Lenders,
                    which request shall specify in reasonable detail the basis
                    therefor, at any time and from time to time, it will
                    provide, at the Borrower's sole cost and expense, an
                    environmental site assessment report and compliance audit
                    concerning any real property in form and substance
                    satisfactory to the Agent, prepared by an environmental
                    consulting firm approved by the Agent addressing the matters
                    in sub-clause (i), (ii) or (iii) above of this Clause
                    13.2.18(e) which gives rise to such request and estimating
                    the range of the potential costs of any removal, remedial or
                    other corrective action in connection with any such matter.
                    If the Borrower fails to provide the same within 90 days
                    after such request was made, the Agent may order the same,
                    and the Obligors shall grant and hereby grant to each of the
                    Agent and the Lenders and their agents access to such real
                    property and specifically grant the Agent and the Lenders an
                    irrevocable non-exclusive license, subject to the rights of
                    tenants, to undertake such an assessment all at the expense
                    of the Borrower (including, without limitation, taking
                    samples of soil, groundwater and suspected asbestos
                    containing materials). Any such investigation of any real
                    property shall be conducted, unless otherwise agreed to by
                    Borrower and Agent, during normal business hours and, to the
                    extent reasonably practicable, shall be conducted so as not
                    to interfere with the ongoing operations at any such real
                    property or to cause any damage or loss to any property at
                    such real property. Borrower and Agent hereby acknowledge
                    and agree that any report of any investigation conducted at
                    the request of Agent pursuant to this Clause 13.2.19(e) will
                    be obtained and shall be used by Agent and Lenders for the
                    purposes of Lenders' internal credit decisions, to monitor
                    and police the Facilities and to protect Lenders' security
                    interests, if any, created by the Finance Documents. Agent
                    agrees to deliver a copy of any such report to Borrower with
                    the understanding that Borrower acknowledges and agrees that
                    (i) it will indemnify and hold harmless Agent and each
                    Lender from any costs, losses or liabilities relating to
                    Borrower's use of or reliance on such report, (ii) neither
                    Agent nor any Lender makes any representation or warranty
                    with respect to such report, and (iii) by delivering such
                    report to Borrower neither Agent nor any Lender is


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                    requiring or recommending the implementation of any
                    suggestions or recommendations contained in such report.

          (f)       Promptly upon, and in any event within five Business Days
                    after, an officer or director of any Obligor obtaining
                    knowledge thereof, written notice of any of the following
                    matters (including all reasonably related claims or
                    liabilities) which could reasonably be expected to result in
                    costs to any Obligor in excess of GBP 2,500,000 shall be
                    delivered to the Lenders:-

(i)       any pending or threatened Environmental Claim against any Obligor
          (including any such claim arising out of the ownership or operation by
          an Obligor, or any predecessor-in-interest thereto, of any real
          property then no longer owned by such Obligor) or any real property
          then owned or operated by an Obligor and any pending or threatened
          suspension, revocation or material modification of any Environmental
          License applicable to such Obligor (including any threatened closure
          or shutdown of all or any part of a facility owned or operated by such
          Obligor);

(ii)      any condition or occurrence on or arising from any real property owned
          or operated by any Obligor (or with respect to which any Obligor has
          liability) that (x) results in material noncompliance by an Obligor
          with any applicable Environmental Law or (y) could reasonably be
          expected to form the basis of an Environmental Claim against an
          Obligor, or any predecessor-in-interest thereto, (including any such
          claim arising out of the ownership or operation by an Obligor of any
          real property then no longer owned by such Obligor) or any real
          property then owned by an Obligor;

(iii)     any condition or occurrence on any real property owned or operated by
          any Obligor that could reasonably be expected to cause such real
          property to be subject to any restrictions on the ownership,
          occupancy, use or transferability by such Obligor of such real
          property under any Environmental Law;

(iv)      the taking of any removal or remedial action in response to the actual
          or alleged presence of any Dangerous Substances on any real property
          owned or operated by an Obligor, or any predecessor-in-interest
          thereto, as required by any Environmental Law or any Governmental
          Authority; and


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(v)       any change or addition to any applicable Environmental Law the effect
          of which change or addition is reasonably likely to have a Material
          Adverse Effect.

                    All such notices shall describe in reasonable detail the
                    nature of the claim, investigation, condition, occurrence or
                    removal or remedial action and the relevant Obligor's
                    response thereto. In addition, the relevant Obligor will
                    provide the Lenders with copies of such detailed reports of
                    any Environmental Claim as may reasonably be requested by
                    the Majority Lenders. In addition, promptly upon receiving
                    written notice of the entry of any real property (or any
                    property with respect to which it or any of its subsidiaries
                    has liability or potential liability) on any register or
                    database maintained by any Governmental Authority or like
                    authority for those properties deemed contaminated with
                    Dangerous Substances including, without limitation, a "black
                    spots" list, inform the Agent of the entry where the entry
                    has or could reasonably be expected to have a Material
                    Adverse Effect.

          (g)       It will, and will procure that each of its subsidiaries
                    will, undertake a suitable site assessment of the
                    Environmental status of any material real property (or any
                    material interest therein) or any company in which it
                    intends or they intend to acquire a majority interest (which
                    assessments shall include, but not be limited to, a written
                    environmental site assessment prepared by a reputable
                    environmental consultant for real property or interests
                    therein acquired or held by any company to be acquired),
                    provided it is so permitted by the then owner of such real
                    property, and will notify the Agent of the results of such
                    assessment.

13.2.19   Intellectual Property

          It will:-

          (a)       make such registrations and pay such fees, registration
                    Taxes and similar amounts as are necessary to keep all
                    Intellectual Property rights which are material to the
                    business of any member of the ChiRex Group in force and to
                    record its interest in those Intellectual Property rights;
                    and

          (b)       take such steps as are necessary and commercially reasonable
                    (including, without limitation, the institution of
                    appropriate legal proceedings) to


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                    prevent third parties from infringing those Intellectual
                    Property rights referred to in paragraph (a) above and
                    (without prejudice to paragraph (a) above) take such other
                    steps as are reasonably practicable to maintain and preserve
                    its interest in those rights.

13.2.20   Investments

          It will not, and will procure that its subsidiaries will not, own any
          interest in any share, equity related investment or investment
          security other than Permitted Investments.

13.2.21   Financial Indebtedness within the ChiRex Group

          It will not, and will procure that its subsidiaries will not, permit
          any Financial Indebtedness or other obligation owed by it to another
          Obligor or to it by another Obligor, to be either (i) contractually
          subordinated to any other obligations, or (ii) evidenced by a note or
          other similar instrument, unless that note or instrument is pledged to
          the Security Agent on behalf of the Lenders in a manner satisfactory
          in all respects to the Security Agent.

13.2.22   Additional Guarantors

          Each Obligor will procure that each of its subsidiaries which either
          after the date of this Agreement becomes a Material Subsidiary (an
          "Existing Material Subsidiary") or is a person to be acquired pursuant
          to Clause 13.2.13 which would be a Material Subsidiary after giving
          effect to such acquisition (an "Acquired Material Subsidiary")
          executes and delivers, except to the extent that (i) such execution
          and delivery is prohibited by law or (ii) it would, in the reasonable
          opinion of the Agent, create an unreasonable risk of liability for the
          directors of such Material Subsidiary after taking into account the
          costs of the contingent liability to the Material Subsidiary
          attributable to the guaranteeing of obligations under the Finance
          Documents versus the benefits to be derived therefrom by such Material
          Subsidiary, in the case of an Existing Material Subsidiary, within 90
          days of availability to the Borrower of information demonstrating that
          such subsidiary has become a Material Subsidiary and, in the case of
          an Acquired Material Subsidiary, substantially contemporaneously with
          the consummation of its acquisition (and in any event within 30 days
          thereafter), to the Agent a Deed of Accession and the


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          documents described in the following sub-clauses (i), (ii) and (iii)
          relevant to it:

(i)       a copy, certified as of the date of the Deed of Accession as true and
          complete by a duly authorised representative of such Material
          Subsidiary of:

                    (A)       the constitutional documents of such Material
                              Subsidiary, including evidence of due
                              incorporation;

                    (B)       board (or other appropriate governing body)
                              resolutions of such Material Subsidiary (A)
                              approving the transactions and the matters
                              contemplated by each of the Finance Documents, and
                              (B) authorising a specified person or persons to
                              (x) execute on its behalf each of the Finance
                              Documents to which it is a party, and (y) give all
                              notices, requests, instructions, certificates and
                              other documents for that Material Subsidiary in
                              connection with each of the Finance Documents to
                              which it is a party;

                    (C)       all other corporate, trust or other applicable
                              authorisations and actions required of it
                              (including without limitation any resolutions of
                              shareholders or approvals of beneficiaries) to
                              enable it to enter into, execute and perform those
                              of the Finance Documents to which it is, or is to
                              be, a party;

                    (D)       specimen signatures of the signatories authorised
                              by such Material Subsidiary in the board (or other
                              appropriate governing body) resolutions described
                              in Clause 13.2.22(i)(B) to sign Financing
                              Documents to which it is or is to be a party; and

                    (E)       all other resolutions, powers, declarations,
                              approvals, consents and licenses (corporate,
                              official or otherwise) necessary or appropriate
                              for the entry into and performance by such
                              Material Subsidiary of the Finance Documents to
                              which it is or is to be a party, and for the
                              enforceability and validity thereof;


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(ii)      a legal opinion properly addressed to the Agent and Lenders from
          reputable counsel acceptable to the Agent in the jurisdiction in which
          such Material Subsidiary is organised or incorporated, who may be
          counsel to ChiRex Inc.; and

(iii)     such other documents as the Agent may reasonably request.

13.2.23   No Payment of Management Fees

          No Obligor will pay to any member of the ChiRex Group which is not an
          Obligor management fees, royalty fees or otherwise except in respect
          of services actually provided on commercially reasonable terms.

13.3      Information and Accounting Undertakings

13.3.1    Events of Default

          ChiRex Inc. will notify the Agent of the occurrence of any Event of
          Default or Potential Event of Default immediately upon becoming aware
          of it and will from time to time on request deliver to the Agent a
          certificate confirming that no Event of Default or Potential Event of
          Default has occurred or setting out details of any Event of Default or
          Potential Event of Default and the action taken or proposed to be
          taken to remedy it.

13.3.2    Books of Account

          Each Obligor will, and will procure that each of its respective
          subsidiaries will, keep proper books of account and will prepare
          management accounts in the usual form and will permit the Agent or any
          authorised representative of the Agent upon reasonable notice to visit
          them and inspect the same at the place where they are maintained and
          to interview such officers and employees of the Borrower as the Agent
          may reasonably require, provided that such visits and interviews may
          not occur more frequently than once a year unless an Event of Default
          has occurred.

13.3.3    Appointment of Auditors

          No Obligor will at any time appoint or continue to employ any auditors
          other than the Auditors or other auditors of international repute
          approved by the Agent, provided that nothing in this Clause 13.3.3
          shall limit or otherwise affect the appointment of statutory auditors.

13.3.4    Financial Statements and Operating Budget


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          The Obligors will deliver, or cause to be delivered, to the Agent in
          form and substance acceptable to the Agent for distribution to the
          Lenders sufficient copies for each of the Lenders of the following:-

          (a)       as soon as available and in any event within the period
                    required to be delivered to the SEC, the Form 10-K of ChiRex
                    Inc. which incorporates the consolidated financial
                    statements of ChiRex Inc. and its subsidiaries, audited by
                    the Auditors as at the end of and for that financial year;

          (b)       as soon as available and in any event within the period
                    required to be delivered to the SEC, the Form 10-Q of ChiRex
                    Inc. which incorporates the unaudited consolidated financial
                    statements of ChiRex Inc. and its subsidiaries and the
                    relevant consolidating adjustments as at the end of, and
                    for, the relevant Accounting Quarter;

          (c)       as soon as available and in any event within 30 days after
                    the end of each fiscal month for the first eleven months of
                    each Accounting Reference Period, consolidated monthly
                    management accounts for each of (i) the ChiRex Group, and
                    (ii) the Borrower (setting forth separately income and
                    expenses of ChiRex (Annan) Limited and ChiRex (Dudley)
                    Limited) each as at the end of such month including, without
                    limitation, a consolidation adjustment column;

          (d)       not more than 30 days after the beginning of each successive
                    Accounting Reference Period, the Operating Budget applicable
                    to such Accounting Reference Period; and

          (e)       within 120 days after the end of each Accounting Reference
                    Period, a report of ChiRex Inc. describing in reasonable
                    detail each of the respective elements of the unconsolidated
                    Cashflow of each Obligor demonstrating the calculations made
                    in order to determine the Cashflow in each such case and, to
                    the extent practicable, reconciling the figures set forth
                    therein to the relevant audited figures;

          provided, that the financial statements provided pursuant to
          Sub-clauses 13.3.4(a), (b) and (c) shall include, without limitation,
          in respect of each Accounting Quarter or Accounting Reference Period,
          as the case may be, a statement of consolidated profit and loss, a
          consolidated balance sheet, a consolidated cash flow statement,


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          together with a comparison of all such information with the
          information, if any such consolidated information is available, for
          the corresponding period in the preceding financial year (or part
          thereof following the date hereof), and the financial statements
          provided pursuant to Sub-clauses 13.3.4(c) to include a comparison
          with the relevant projections, estimates or forecasts in the relevant
          Operating Budget.

13.3.5    Financial Covenant and Other Compliance Certificates

          Each of the financial statements delivered under Subclauses 13.3.4(a),
          (b) and (c) shall be accompanied by a certificate signed by the chief
          financial officer of ChiRex Inc. and (in the case of financial
          statements delivered pursuant to Sub-clause 13.3.4(a) approved by a
          the Board of Directors of ChiRex Inc., certifying whether or not the
          Obligors are in compliance with each of the covenants contained in
          Clause 13.4 (such certificate to contain detailed calculations
          reasonably acceptable to the Agent demonstrating such determination),
          confirming that at the date of such financial statement, no Event of
          Default or Potential Event of Default has occurred, or if one has
          occurred, a description thereof and the action taken or proposed to be
          taken to remedy it and, in the case of the annual financial
          statements, (i) listing each Material Subsidiary as at the date of
          such annual financial statements, and (ii) accompanied by a
          certificate from the Auditors (in such form and with such content as
          the Agent may reasonably require) demonstrating whether or not the
          Obligors are in compliance with the covenants contained in Clause
          13.4.

13.3.6    Accounting Reference Period/Accounting Quarter

          No alteration may be made to its Accounting Reference Period or
          Accounting Quarters without the prior written consent of the Agent
          (which consent shall not be unreasonably withheld). The Agent may
          require such changes in the financial covenants contained in this
          Agreement as will fairly reflect any such change.

3.3.7     Auditors' Investigations

          [*** Clause Reserved ***]

13.3.8    Other Information

          Each Obligor (or each US Obligor, as applicable) will promptly deliver
          to the Agent for distribution to the Lenders:-


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          (a)       details of any litigation, arbitration or administrative
                    proceedings relating to such Obligor which is reasonably
                    likely to give rise to a Material Adverse Effect;

          (b)       at the same time as sent to any of its financial creditors,
                    any other material document or information sent to such
                    creditors;

          (c)       such other information relating to its financial condition
                    or operations (including sales and details in relation to
                    its debtors), or those of any other Obligor as the Agent (or
                    any other Lender through the Agent) may from time to time
                    reasonably request;

          (d)       details of any occurrence or circumstance which will
                    materially adversely affect the ability of any Obligor to
                    perform any of its payment obligations under any of the
                    Finance Documents;

          (e)       promptly upon becoming aware of any event or circumstance
                    pertaining to an Employee Benefit Plan which is reasonably
                    likely to give rise to a Material Adverse Effect, a written
                    notice specifying the nature thereof, what action the
                    relevant US Obligor or any of its ERISA Affiliates has
                    taken, is taking or proposes to take with respect thereto
                    and, when known, any action taken or threatened by the
                    United States Internal Revenue Service, the United States
                    Department of Labor or the PBGC with respect thereto; and

          (f)       a copy of any notice or other writing received or issued by
                    any Obligor in connection with the possible termination,
                    revocation or modification of the terms of any license,
                    consent or authorisation necessary for the carrying on of
                    the Business, or the termination, waiver, amendment or
                    variance of any Material Agreement.

13.3.9    Other Investigations

          It will, and will procure that its subsidiaries will, at any time
          during the occurrence of a Potential Event of Default or an Event of
          Default, permit the Agent and such person or persons as the Agent
          shall nominate at all reasonable times during normal business hours
          and on not less than 24 hours' written notice to enter into and upon
          the principal premises from which the relevant Obligor's or
          subsidiary's business is being conducted to view the state and
          condition of such premises.

13.3.10   Approved Accounting Principles


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          All audited financial statements or accounts of the Obligors delivered
          or to be delivered to the Agent under this Agreement shall be prepared
          in accordance with the relevant Approved Accounting Principles. If,
          (i) as a result of a change in law or other change in Approved
          Accounting Principles such statements or accounts are required to be
          prepared on a different basis, or (ii) any change in Approved
          Accounting Principles would result in any material change in the
          manner in which any item relevant to the covenants in Clause 13.4
          (Financial Covenants) is accounted for or reported by any Obligor, or
          (iii) any Obligor shall propose to change its Approved Accounting
          Principles from those specified in the definitions herein:-

          (a)       the relevant Obligor shall promptly so advise the Agent, and
                    shall deliver to the Agent (with sufficient copies for the
                    Lenders) the Operating Budget for the then current
                    Accounting Reference Period and the financial statements
                    required to be delivered under Clauses 13.3.4(a) and (b)
                    during the prior twelve month period, in each case, giving
                    effect to the relevant changes;

          (b)       on request of the Agent (which request shall be deemed made
                    in the case of a proposal to change any of the Approved
                    Accounting Principles from those specified in the
                    definitions herein), the Obligors and the Agent (on behalf
                    of the Lenders) shall negotiate in good faith with a view to
                    agreeing such amendments to Clauses 13.4 and/or the
                    definitions of any or all of the terms used therein as are
                    necessary as a result of such change in law or in generally
                    accepted accounting principles (or other change) to give the
                    Lenders comparable protection to that contemplated at the
                    date of this Agreement;

          (c)       if amendments satisfactory to the Lenders are agreed by the
                    Obligors and the Agent in writing within 30 days of such
                    notifications to the Agent, those amendments shall take
                    effect in accordance with the terms of that agreement; and

          (d)       if such amendments are not so agreed within 30 days, within
                    15 days after the end of that 30 day period, the relevant
                    Obligor shall either:-

(i)       deliver to the Agent, in reasonable detail and in a form satisfactory
          to the Agent, details of all such adjustments as need to be made to
          the relevant financial statements in order to bring them into line
          with Approved


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          Accounting Principles or, as the case may be, to eliminate the effect
          of the relevant change; or

(ii)      ensure that the relevant financial statements are prepared in
          accordance with the relevant Approved Accounting Principles subject,
          as the case may be, to eliminating the effect of the relevant change.

13.3.11   Annual Meeting with Banks

          At the request of the Agent, the Obligors shall within 120 days after
          the close of each Accounting Reference Period, hold a meeting at a
          time and place selected by the Obligors and reasonably acceptable to
          the Agent, with all of the Lenders at which meeting shall be reviewed
          the financial results of the previous fiscal year, the financial
          condition of the Obligors and the Operating Budget for the then
          current fiscal year of the Obligors.

13.4      Financial Covenants

13.4.1    (a)       Maximum Total Debt / EBITDA Ratio

                    ChiRex Inc. shall maintain, as of the end of each Accounting
                    Quarter to occur during the periods shown below, a Total
                    Debt/EBITDA Ratio of not more than the maximum Total
                    Debt/EBITDA Ratio shown below:

                ================================================================
                                                          Maximum Total
                                                           Debt/EBITDA
                          Period                              Ratio
                ----------------------------------------------------------------
                1st April, 1998 to 30th June, 1998          3.25 : 1
                ----------------------------------------------------------------
                1st July, 1998 to 30th September,           3.0 : 1
                1998
                ----------------------------------------------------------------
                Thereafter                                  2.5 : 1
                ================================================================

          (b)       Minimum Interest Coverage Ratio

                    ChiRex Inc. shall maintain, as of the end of each Accounting
                    Quarter to occur during the periods shown below, an Interest
                    Coverage Ratio of not less than the minimum Interest
                    Coverage Ratio shown below:


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                      ==========================================================
                                                                 Minimum
                                                                 Interest
                               Period                          Coverage Ratio

                      ----------------------------------------------------------
                      1st April, 1998 to 30th September,          3.0 : 1
                      1998
                      ----------------------------------------------------------
                      Thereafter                                  3.5 : 1
                      ==========================================================

          (c)       Calculation

(i)       The covenants contained in this Clause 13.4.1 will be tested on a
          rolling aggregate basis for the immediately preceding four quarterly
          periods ending on the last day of the relevant Accounting Quarter
          (except that Total Debt will be tested as of the last day of the
          Accounting Quarter most recently ended), in each case by reference to
          the quarterly management accounts in respect of the first three
          Accounting Quarters of each Accounting Reference Period, delivered to
          the Agent pursuant to Clauses 13.3.4(b), for the relevant period, and
          by reference to the audited accounts required to be delivered to the
          Agent pursuant to Clause 13.3.4(a) in respect of the fourth Accounting
          Quarter of each Accounting Reference Period; provided that if when the
          audited accounts become available they either demonstrate that the
          figures in any relevant quarterly management accounts utilised for any
          such calculation cannot have been substantially accurate or indicate a
          material discrepancy which is prejudicial to the Finance Parties
          between the aggregate figures for the management accounts for the four
          relevant Accounting Quarters and the aggregate audited figures, then
          the Agent shall require such adjustment to the calculations made or to
          be made as it reasonably considers appropriate to rectify such
          inaccuracy or discrepancy, and compliance with the covenants in this
          Clause 13.4.1 will be determined by reference to such adjusted
          figures.

(ii)      In the case of any component calculated by reference to management
          accounts the relevant Approved Accounting Principles will be applied
          within the reasonable parameters which may be expected of management
          accounts not the subject of audit procedures.

13.4.2    Capital Expenditure

          (a)       Before the Achievement Date only, ChiRex Inc. shall procure
                    that the Capital Expenditures (determined in


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                    accordance with Approved Accounting Principles) of the
                    ChiRex Group in each Accounting Reference Period ending
                    after the date of this Agreement do not exceed the sum of
                    (i) the amount set forth in respect thereof in the Business
                    Plan and (ii) an amount which, when added to any other
                    Restricted Payments, does not exceed in aggregate the
                    Available Amount; provided that for any Accounting Reference
                    Period of less than twelve months, the permitted amount of
                    Capital Expenditures shall be pro-rated accordingly.

          (b)       Without prejudice to the other terms of this Agreement, upon
                    each disposal of a business or company (or a material part
                    of either), the amount specified in Clause 13.4.2(a), if
                    applicable, shall be automatically reduced by the amount (if
                    any) reasonably determined by the Agent to be attributable
                    to that business, company or part thereof.

          (c)       Notwithstanding the foregoing, to the extent that the actual
                    Capital Expenditures (as so calculated) during any
                    Accounting Reference Period are less than the amount
                    permitted by Clause 13.4.2(a) for such Accounting Reference
                    Period, 100% of such unused amount shall be added to the
                    amount of permitted Capital Expenditures in any succeeding
                    year subject to no Event of Default having occurred and
                    being continuing at the time of a proposed usage of all or
                    any part of such unused amount in such succeeding year.

13.5      Additional Undertakings of ChiRex Inc.

          ChiRex Inc. undertakes that:

          (a)       Business

                    It will not engage in any business or activity other than
                    the ownership of the shares of capital stock of its
                    subsidiaries, and activities necessarily related thereto.

          (b)       Ownership

                    It will at all times own beneficially and of record 100% of
                    the outstanding shares of capital stock of ChiRex America
                    Inc. and the Borrower.

          (c)       Financial Indebtedness, Etc.


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It will procure that (i) none of ChiRex America Inc., ChiRex (Annan) Limited,
nor the Borrower has any Financial Indebtedness, except (A) in the case of the
Borrower only, its obligations in respect of the Finance Documents and the
Holdings Note, and (B) in the case of ChiRex (Annan) Limited only, its
obligations under the Finance Documents, the Annan Note and the Multiborrower
Revolving Note, (ii) the Borrower has no material assets, other than the shares
of capital stock of its subsidiaries and such assets as arise in connection with
the use of proceeds of the Advances, and (iii) ChiRex America Inc. has expenses
not exceeding GBP 2,500,000 in any Accounting Reference Period.


14.           EVENTS OF DEFAULT

14.1          List of Events

              Each of the events set out in this Clause 14.1 constitutes an
              Event of Default whether or not the occurrence of the event
              concerned is outside the control of the Obligors or any other
              person.

14.1.1        Payment Default

              Any Obligor fails to pay on the due date any amount payable by it
              under any of the Finance Documents at the place at which, and in
              the currency in which, it is expressed to be payable but, without
              prejudice to Clause 27.1, such non-payment shall not constitute an
              Event of Default if (i) it is a non-payment in respect of interest
              or fees and the relevant payment is received by the Agent within
              three Business Days of the due date for payment thereof, or (ii)
              such non-payment is caused by a technical fault in transmission of
              funds and such funds are subsequently successfully transmitted
              within one Business Day of the due date for payment thereof.

14.1.2        Breach of Other Obligations

              (a)     a breach of any provision of Clause 13.4 (Financial
                      Covenants) occurs;

              (b)     any Obligor fails to comply with any of its obligations in
                      Clause 13 (other than Clause 13.4) and, in any such case,
                      if such failure is, in the reasonable opinion of the
                      Agent, capable of remedy,


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              (c)     it is not remedied within twenty  Business Days
                      after such Obligor becomes aware of such failure; or

              (d)     any Obligor fails to comply with or perform any of its
                      other material obligations or undertakings under any of
                      the Finance Documents and, if such failure is, in the
                      reasonable opinion of the Agent, capable of remedy, it is
                      not remedied within twenty Business Days after such
                      Obligor becomes aware of such failure.

14.1.3    Misrepresentation

          Any representation, warranty or statement which is made by any Obligor
          in any of the Finance Documents or is contained in any certificate,
          statement or notice provided under or pursuant to any of the Finance
          Documents proves to be incorrect in any material respect when made (or
          deemed to be repeated) unless the circumstances giving rise to that
          default are, in the reasonable opinion of the Agent, remediable, and
          are remedied within twenty Business Days after such Obligor becoming
          aware of the same.

14.1.4    Invalidity, Unlawfulness, Etc.

          (a)       Any provision of any Finance Document is, or becomes,
                    materially invalid or unenforceable for any reason (except
                    by reason of the unavailability of specific performance or
                    other equitable remedy) or shall be repudiated or the
                    validity or enforceability of any provision of any Finance
                    Document shall at any time be contested by any Obligor party
                    thereto, or any Obligor shall deny the existence of any
                    liability or obligation on its part thereunder.

          (b)       At any time it is or becomes unlawful under the laws of any
                    applicable jurisdiction for any Obligor (other than a
                    Non-Material Subsidiary) to perform any of its material
                    obligations under any Finance Document.

          (c)       At any time any act, condition or thing required to be done,
                    fulfilled or performed in order (i) to enable any Obligor
                    lawfully to enter into, exercise its rights under and
                    perform the material obligations expressed to be assumed by
                    it in any of the Finance Documents or (ii) to ensure that
                    the material obligations expressed to be assumed by any
                    Obligor in any Finance Document are legal, valid and


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                    binding, is not done, fulfilled or performed, and if the
                    relevant matter is, in the reasonable opinion of the Agent,
                    capable of remedy, it is not remedied within fourteen
                    Business Days after the first of such Obligor becomes aware
                    of such matter.

14.1.5    Insolvency

          Subject to Clause 14.2, any Obligor is declared insolvent or is
          unable, or admits in writing its inability, to pay its debts as they
          fall due or stops or threatens to stop payment of its debts generally
          or becomes insolvent within the terms of any applicable law.

14.1.6    Receivership and Administration

          Subject to Clause 14.2,

          (a)       an application is made for the appointment of an
                    administrator (as such term is used in the Insolvency Act
                    1986) or similar official in relation to any Obligor or a
                    resolution is passed by the directors or shareholders of
                    ChiRex Inc. or any such Obligor for such an application to
                    be made;

          (b)       a liquidator, trustee, administrative or other receiver,
                    manager (being a person acting on behalf of all or any
                    creditors), judicial factor, manager for credits, or similar
                    officer is appointed in respect of (or takes possession of)
                    any Obligor or in respect of (or takes possession of) all or
                    any part of its assets; or

          (c)       any distress, execution, attachment (other than an
                    attachment or arrest to found jurisdiction) or other process
                    affects any asset of any Obligor, except where such Obligor
                    is, in good faith, reasonably contesting such distress,
                    execution, attachment or other process by proceedings
                    diligently pursued and such distress, execution, attachment
                    or other process is discharged or stayed within 30 days.

14.1.7    Compositions and Arrangements

          Subject to Clause 14.2, a moratorium or suspension of payments in
          respect of all or any classes of debts of any Obligor or a composition
          or an arrangement with creditors generally of any Obligor or any other
          arrangement whereby its affairs are submitted to the control of its
          creditors is applied for, ordered or declared.


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14.1.8    Winding-up or Similar Event

          Subject to Clause 14.2, any order is made or resolution passed or any
          legal proceedings are consented to by any Obligor or otherwise
          commenced (by way of petition or otherwise) for the suspension of
          payments generally or dissolution, termination of existence,
          liquidation, winding-up or bankruptcy of any Obligor.

14.1.9    Protection from Creditors

          Subject to Clause 14.2, any order is made, decree is passed or
          resolution is passed or other action is taken by or with respect to
          any obligor for protection from creditors of such Obligor.

14.1.10   Similar Events Elsewhere

          Subject to Clause 14.2, there occurs in relation to any Obligor or any
          of their respective assets, in any country or territory in which such
          Obligor is organised or carries on business or to the jurisdiction of
          whose courts it or any of its assets are subject, any event which
          corresponds in that country or territory with any of those mentioned
          in Clauses 14.1.5 to 14.1.9 (inclusive) (including, without
          limitation, the filing of any petition or the commencement of any
          proceedings under any U.S. federal or state bankruptcy, insolvency,
          reorganisation or other similar law), or any Obligor or its assets
          otherwise become subject, in any such country or territory, to any law
          relating to insolvency, bankruptcy or liquidation.

14.1.11   Cessation of Business

          Subject to Clause 14.2, any Obligor ceases, or threatens to cease, to
          carry on all or a substantial part of its business, other than in
          connection with a transfer by such Obligor of all or substantially all
          of its assets in accordance with Clause 13.2.8(g).

14.1.12   Compulsory Acquisition

          All or any part of the property or assets of any Obligor is
          compulsorily acquired by, or by the order of, any central or local
          governmental authority and such acquisition results in a Material
          Adverse Effect.

14.1.13   Security Interests


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          Any Security Interest securing obligations or liabilities in excess of
          GBP 2,500,000 (or its equivalent), affecting the business, undertaking
          or any of the assets of any Obligor becomes enforceable (other than by
          the exercise of a lien arising solely by operation of law in the
          ordinary course of trading where the indebtedness in respect of which
          that lien is being exercised (i) has been due for less than twenty
          days or (ii) is being contested in good faith by appropriate means)
          whether or not steps are taken to enforce the same.

14.1.14   Cross Default

          (a)       Any other Financial Indebtedness in excess of GBP 2,500,000
                    (or its equivalent) of any Obligor:-

(i)       is not paid when due or within any applicable grace period in any
          agreement relating to that Financial Indebtedness; or

(ii)      becomes due and payable (or presently capable of being declared due
          and payable) before its normal maturity or is placed upon demand
          before it is due (or any commitment for any such indebtedness is
          cancelled or suspended) by reason of a default or event of default,
          however described, or by reason of any other contractual provision
          requiring prepayment; or

          (b)       Any amount due under a WCP Facility becomes due and payable
                    (or presently capable of being declared due and payable)
                    before its normal maturity or is placed on demand before its
                    time (or any WCP Commitment for any WCP Facility is
                    cancelled or suspended) by reason of a default, however
                    described, relating thereto.

14.1.15   Auditors' Qualification

          The Auditors qualify their report on the audited consolidated
          financial statements of any Obligor in any way whatsoever.

14.1.16   Material Adverse Effect

          An event or circumstance occurs or exists which has, or is reasonably
          likely to have, a Material Adverse Effect.

14.1.17   Litigation

          Any litigation, arbitration or administrative proceedings are current
          or pending at the date of this Agreement or


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          are commenced after such date against any Obligor, which proceedings
          are reasonably likely to have a Material Adverse Effect.

14.1.18   Environmental Defaults

          (a)       any Obligor fails to comply with any Environmental Law or
                    Environmental License or becomes subject to any liability or
                    potential liability in respect of Dangerous Substances and
                    that non-compliance or liability or potential liability
                    could reasonably be expected to have a Material Adverse
                    Effect;

          (b)       if any entry on any register maintained by any government or
                    like authority for those properties deemed contaminated with
                    Dangerous Substances, including, without limitation, a
                    "black spots" list, is made in respect of any property owned
                    by any Obligor (or with respect to which property any
                    Obligor has any liability or potential liability) and as a
                    result of such registration there is a fall in the value of
                    the property in question which could reasonably be expected
                    to have a Material Adverse Effect;

          (c)       any change in applicable Environmental Law results in the
                    imposition of any liability on any Finance Party in relation
                    to any Environmental Event which liability is reasonably
                    likely to have a Material Adverse Effect; or

          (d)       any change in applicable law causes the rights of any person
                    in relation to any Environmental Claim against any Obligor
                    to rank ahead of the rights of any Finance Party against it
                    in a manner which could reasonably be expected to have a
                    Material Adverse Effect.

14.1.19   Judgement Default

          Any final judgement, decree or order (not covered by insurance) for
          the payment of money in excess of GBP 2,500,000 against all such
          persons (treating any deductibles, self-insurance or retention as not
          so covered) shall be rendered against any Obligor and shall not be
          discharged, and there shall be any period of 30 consecutive days
          following entry of such final judgement, decree or order during which
          a stay of enforcement of such final judgement, decree or order, by
          reason of a pending appeal or otherwise, shall not be in effect.


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14.1.20   Employee Benefit Plans

          An event or condition occurs or exists with respect to any Employee
          Benefit Plan and as a result of such event or condition, together with
          all other such events or conditions, a US Obligor or any ERISA
          Affiliate thereof has incurred or is reasonably likely to incur a
          liability to a Employee Benefit Plan, the PBGC or a trustee appointed
          pursuant to Section 4042 of ERISA (or any combination of the
          foregoing) which is reasonably likely to have a Material Adverse
          Effect.

14.1.21   Licenses, Authorisations, Material Agreements

          Any license, consent or authorisation necessary for the carrying on of
          the Business shall be terminated or revoked or the terms thereof shall
          be modified, or any Material Agreement shall cease to be in full force
          and effect, or the party thereto not a member of the ChiRex Group (or
          its successor) shall give notice to terminate prior to its scheduled
          termination date such Material Agreement in accordance with its terms,
          or any term of such Material Agreement shall be waived, amended or
          varied, in any case where the relevant event (taking into account any
          replacement or other compensating agreement or order secured by any
          member of the ChiRex Group) is reasonably likely to have a Material
          Adverse Effect.

14.2      Bankruptcy and Insolvency Types of Events of Default

          Notwithstanding the terms of Clauses 14.1.5 through 14.1.11
          (inclusive), the occurrence of any event described under such Clauses
          with respect to any subsidiary of the Borrower shall not constitute an
          Event of Default if the Borrower shall have, not less than twenty days
          prior to the occurrence of such event, provided evidence satisfactory
          to the Agent that, the occurrence of such event is not reasonably
          likely either to (i) have a Material Adverse Effect or (ii) to result
          in the incurrence by the Lenders of any material liabilities or
          claims.

14.3      Cancellation and Repayment

          At any time after the occurrence and during the continuance of an
          Event of Default the Agent may and, if so instructed by the Majority
          Lenders, will by notice to the Borrower:-


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          (a)       cancel any unborrowed amount of the Facilities (whereupon
                    the commitment of each Lender in respect to each Facility
                    shall be reduced to zero); and/or

          (b)       declare all Advances, accrued interest thereon and any other
                    sum accrued under this Agreement and any of the other
                    Finance Documents to be immediately due and payable,
                    whereupon they shall become so due and payable.

15.       GUARANTEE

15.1      Guarantee

          Subject to any limitations specified for the relevant Guarantor in its
          Deed of Accession and subject to Clause 15.2 below, each Guarantor
          irrevocably and unconditionally:-

          (a)       as principal obligor, waiving any benefit under applicable
                    law, guarantees to each Finance Party, prompt performance by
                    each Obligor (any reference in this Guarantee to one or more
                    Obligors shall not be construed to include a reference by a
                    Guarantor to itself in its capacity as a Guarantor), of all
                    its respective obligations under the Finance Documents (the
                    "Guarantee Obligation");

          (b)       undertakes with each Finance Party that whenever an Obligor
                    does not pay any amount when due under or in connection with
                    any Finance Document, such Guarantor shall forthwith on
                    demand by the Agent pay that amount (the "Payment
                    Obligation") as if such Guarantor instead of the relevant
                    Obligor were expressed to be the principal obligor; and

          (c)       indemnifies each Finance Party on demand against any loss or
                    liability suffered by it under the Finance Documents as a
                    result of any obligation guaranteed by such Guarantor being
                    or becoming unenforceable, invalid or illegal.

15.2      Limitation on Guarantee Obligations

          Anything contained in this Clause 15 to the contrary notwithstanding,
          if any Fraudulent Transfer Law (as hereinafter defined) is determined
          by any United States court of competent jurisdiction to be applicable
          to the obligations of any US Obligor under the Guarantee set forth in
          this Clause 15, such obligations of such US Obligor hereunder shall be
          limited to a maximum aggregate amount equal to the largest


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          amount that would not render its obligations hereunder subject to
          avoidance as a fraudulent transfer or conveyance under Section 548 of
          Title 11 of the United States Code or any applicable provisions of
          comparable state law, to the extent applicable to any respective
          guarantee of any US Obligor (collectively, the "Fraudulent Transfer
          Laws"), in each case after giving effect to all other liabilities of
          such US Obligor, contingent or otherwise, that are relevant under the
          Fraudulent Transfer Laws (specifically excluding, however, any
          liabilities of such US Obligor in respect of intercompany indebtedness
          to any other member of the ChiRex Group to the extent that such
          indebtedness would be discharged in an amount equal to the amount paid
          by such US Obligor hereunder) and after giving effect as assets to the
          value (as determined under the applicable provisions of the Fraudulent
          Transfer Laws) of any rights to subrogation, reimbursement,
          indemnification or contribution of such US Obligor pursuant to
          applicable law or pursuant to the terms of any agreement.

15.3      Joint and Several Liability

          Subject to any limitations specified for the relevant Obligor in its
          Deed of Accession, if applicable, each obligation expressed under this
          Agreement to be an obligation of the Obligors shall be the joint and
          several obligation of each Obligor.

15.4      Continuing Guarantee

          This guarantee is a continuing guarantee and will extend to the
          ultimate balance of all sums payable by the Obligors under the Finance
          Documents, regardless of any intermediate payment or discharge in
          whole or in part.

15.5      Reinstatement

          (a)       Where any discharge (whether in respect of the obligations
                    of any Obligor or any security for those obligations or
                    otherwise) is made in whole or in part or any arrangement is
                    made on the faith of any payment, security or other
                    disposition which is avoided or must be restored on
                    insolvency, liquidation or otherwise without limitation, the
                    liability of each Guarantor under this Clause 15 shall
                    continue as if the discharge or arrangement had not
                    occurred.

          (b)       Each Finance Party may concede or compromise any claim that
                    any payment, security or other disposition is liable to
                    avoidance or restoration.

15.6      Waiver of Defences


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          The obligations of each Guarantor under this Clause 15 will not be
          affected by, and each Guarantor waives its rights (to the fullest
          extent permitted by law) in connection with, any act, omission, matter
          or thing which, but for this provision, would reduce, release or
          prejudice any of its obligations under this Clause 15 or prejudice or
          diminish those obligations in whole or in part, including (whether or
          not known to it or any Finance Party):-

          (a)       any time or waiver granted to, or composition with, any
                    Obligor or any other person;

          (b)       the taking, variation, compromise, exchange, renewal or
                    release of, or refusal or neglect to perfect, take up or
                    enforce, any rights against, or security over assets
                    (including any balance of any deposit or account or credit
                    on the books of any Finance Party or other person in favour
                    of any Obligor or any other person) of, any Obligor or other
                    person or any non-presentation or non-observance of any
                    formality or other requirement in respect of any instrument
                    or any failure to realise the full value of any security;

          (c)       any incapacity or lack of powers, authority or legal
                    personality of or dissolution or change in the members or
                    status of any Obligor or any other person;

          (d)       any variation (however fundamental) or replacement of a
                    Finance Document or any other document or security so that
                    references to that Finance Document in this Clause 15 shall
                    include each variation or replacement;

          (e)       any unenforceability, illegality or invalidity of any
                    obligation of any person under any Finance Document or any
                    other document or security, to the intent that such
                    Guarantor's obligations under this Clause 15 shall remain in
                    full force and its guarantee be construed accordingly, as if
                    there were no unenforceability, illegality or invalidity; or

          (f)       any postponement, discharge, reduction, non-provability or
                    other similar circumstance affecting any obligation of any
                    Obligor under a Finance Document resulting from any
                    insolvency, liquidation or dissolution proceedings or from
                    any law, regulation or order so that each such obligation
                    shall for the purposes of each Guarantor's


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                    obligations under this Clause 15 be construed as if there
                    were no such circumstance.

15.7      Immediate recourse

          Each Guarantor waives any right it may have of first requiring any
          Finance Party (or any trustee or agent on its behalf) to (i) proceed
          against or enforce any other rights or security or claim payment from
          any person, or (ii) pursue any other remedy in the power of any
          Finance Party whatsoever, before enforcing its rights against such
          Guarantor under this Clause 15.

15.8      Appropriations

          Until all amounts which may be or become payable by the Obligors under
          or in connection with the Finance Documents have been irrevocably paid
          in full, each Finance Party (or any trustee or agent on its behalf)
          may:-

          (a)       refrain from applying or enforcing any other moneys,
                    security or rights held or received by that Finance Party
                    (or any trustee or agent on its behalf) in respect of those
                    amounts, or apply and enforce the same in such manner and
                    order as it sees fit (whether against those amounts or
                    otherwise) and no Guarantor shall be entitled to the benefit
                    of the same; and

          (b)       hold in a market rate interest-bearing suspense account any
                    moneys received from each Guarantor or on account of such
                    Guarantor's liability under this Clause 15, with interest
                    accruing thereon for the account of such Guarantor at a rate
                    determined by such Finance Party, acting reasonably, to be
                    appropriate in the circumstances.

15.9      Non-competition

          Until all amounts which may be or become payable by the Obligors under
          or in connection with the Finance Documents have been irrevocably paid
          in full, each Guarantor shall not, after a claim has been made or by
          virtue of any payment or performance by it under this Clause 15:-

          (a)       be subrogated to any rights, security or moneys held,
                    received or receivable by any Finance Party (or any trustee
                    or agent on its behalf) or be entitled to any right of
                    contribution or indemnity


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                    in respect of any payment made or moneys received on account
                    of such Guarantor's liability under this Clause 15;

          (b)       without the consent of the Agent, claim, rank, prove or vote
                    as a creditor of any Obligor or its estate in competition
                    with any Finance Party (or any trustee or agent on its
                    behalf); or

          (c)       receive, claim or have the benefit of any payment,
                    distribution or security from or on account of any Obligor,
                    or exercise any right of set-off as against any Obligor.

          Each Guarantor shall hold in trust for and forthwith pay or transfer
          to the Agent for the Finance Parties any payment or distribution or
          benefit of security received by it contrary to this Clause 15.9.

15.10     Additional Security, Relation to Other Obligations of Guarantors

          This guarantee is in addition to and shall not in any way be
          prejudiced by any other security now or hereafter held by any Finance
          Party.

16.       THE AGENT AND THE OTHER FINANCE PARTIES

16.1      Appointment and duties of the Agent, Security Agent and Joint
          Arrangers

16.1.1    Each Lender hereby appoints (i) Bankers Trust Company as Agent, to act
          as its agent in connection with the Finance Documents, (ii) Bankers
          Trust Company as Security Agent, to act as security agent for purposes
          of the Security Documents, and (iii) Bankers Trust International PLC
          and Midland Bank plc to act as Joint Arrangers, under and in
          connection with the Finance Documents, and irrevocably authorises
          Bankers Trust Company for and on its behalf to exercise such rights,
          powers and discretions as are specifically delegated to it by the
          terms of the Finance Documents, together with all such rights, powers
          and discretions as are incidental thereto, and to give a good
          discharge for any moneys payable under the Finance Documents. The
          Lenders empower the Agent or the Security Agent, as the case may be,
          on the broadest terms to take such actions and to exercise any and all
          rights derived from this Agreement, including, but not limited to (i)
          the enforcement of the Finance Documents, and (ii) the


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          sending or receiving of whatever notices or communications the Agent
          may deem necessary or advisable.

16.1.2    The Agent will act solely as agent for the Lenders in carrying out its
          functions as agent under the Finance Documents and will exercise the
          same care as it would in dealing with a credit for its own account.

16.1.3    The relationship between the Lenders and the Agent is that of
          principal and agent only. The Agent shall not have, nor be deemed to
          have assumed, any obligations to, or trust or fiduciary relationship
          with, the other Finance Parties or ChiRex Inc. or any member of the
          ChiRex Group other than those for which specific provision is made by
          the Finance Documents.

16.1.4    References in this Clause 16 to "Agent" shall be deemed also to be
          references to the Agent in its capacities as Security Agent and Joint
          Arranger (save where specific reference is made to the contrary),
          notwithstanding the use of the expression "the Agent and the Security
          Agent" in certain provisions of the Finance Documents.

16.2      Agent's Duties

          The Agent shall:-

16.2.1    promptly send to each Lender details of each communication received by
          it from ChiRex Inc., the Borrower or the members of the ChiRex Group
          under the Finance Documents, except that details of any communication
          relating to a particular Lender shall be sent to that Lender only;

16.2.2    promptly send to each Lender a copy of any legal opinion delivered
          under this Agreement or any of the other Finance Documents and of any
          document or information received by it pursuant to Clause 13.3
          (Information and Accounting Undertakings) or (if requested) pursuant
          to Clause 4.1;

16.2.3    subject to those provisions of this Agreement which require the
          consent of all the Lenders, act in accordance with any instructions
          from the Majority Lenders or, if so instructed by the Majority
          Lenders, refrain from exercising a right, power or discretion vested
          in it under this Agreement or any of the Finance Documents;

16.2.4    have only those duties, obligations and responsibilities expressly 
          specified in the Finance Documents; and


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16.2.5    without prejudice to any other clause hereof (including without
          limitation Clauses 16.3.5, 16.4(c) and 16.6.3), promptly notify each
          Lender of the occurrence of any Event of Default or Potential Event of
          Default of which an officer of the Agent responsible for the
          administration of this Agreement becomes aware.

16.3      Agent's and Security Agent's Rights

          The Agent and the Security Agent, as the case may be, may:-

16.3.1    perform any of its duties, obligations and responsibilities under the
          Finance Documents by or through its personnel, delegates or agents (on
          the basis that the Agent and/or Security Agent may extend the benefit
          of any indemnity received by it hereunder to its personnel, delegates
          or agents);

16.3.2    refrain from exercising any right, power or discretion vested in it
          under the Finance Documents until it has received instructions from
          the Majority Lenders, or where relevant, all the Lenders;

16.3.3    unless it has received notice in writing to the contrary treat (a) the
          Lender which makes available any portion of an Advance as the person
          entitled to repayment of that portion and (b) the office set under a
          Lender's name in Schedule 1 (or, in the case of a Transferee, at the
          end of the Transfer Certificate to which it is a party as Transferee)
          as its Lending Office;

16.3.4    refrain from doing anything which would or might in its opinion be
          contrary to any law, regulation, directive, judgement or decree of any
          court of any jurisdiction or otherwise render it liable to any person
          and may do anything which is in its opinion necessary to comply with
          any such law, regulation, judgement, decree or directive;

16.3.5    assume that no Event of Default or Potential Event of Default has
          occurred unless an officer of the Agent while active on the account of
          the Borrower acquires actual knowledge to the contrary;

16.3.6    refrain from taking any step (or further step) to protect or enforce
          the rights of any Lender under this Agreement or any of the other
          Finance Documents until it has been indemnified and/or secured to its
          satisfaction against any and all costs, losses, expenses or
          liabilities (including legal fees) which it would or might sustain or
          incur as a result;


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16.3.7    rely on any communication or document believed by it to be genuine and
          correct and to have been communicated or signed by the person to whom
          it purports to be communicated and signed;

16.3.8    rely as to any matter of fact which might reasonably be expected to be
          within the knowledge of the Borrower on a statement by or on behalf of
          the Borrower;

16.3.9    obtain and pay for such legal or other expert advice or services as
          may seem necessary to it or desirable and rely on any such advice.

16.3.10   accept without enquiry such title as the Obligors may have to any
          asset or assets intended to be the subject of the security created by
          the Security Documents; and

16.3.11   hold or deposit any title deeds, the Security Documents or any other
          documents in connection with any of the assets charged by the Security
          Documents with any banker or banking company or any company whose
          business includes undertaking the safe custody of deeds or documents
          or with any lawyer or firm of lawyers and it shall not be responsible
          for or be required to insure against any loss incurred in connection
          with any such holding or deposit and it may pay all sums required to
          be paid on account or in respect of any such deposit.

16.4      Exoneration of Agent, Security Agent and Joint Arrangers

          Neither the Agent nor the Security Agent nor the Joint Arrangers nor
          any of their respective personnel or agents:-

          (a)       shall be responsible for the adequacy, accuracy or
                    completeness of any representation, warranty, statement or
                    information in the Information Memorandum, any of the
                    Finance Documents or any notice or other document delivered
                    under the Finance Documents;

          (b)       shall be responsible for the execution, delivery, validity,
                    legality, adequacy, enforceability or admissibility in
                    evidence of any of the Finance Documents;


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          (c)       shall be obliged to enquire as to the occurrence or
                    continuation of an Event of Default or a Potential Event of
                    Default;

          (d)       shall be responsible for any failure of any member of the
                    ChiRex Group or any of the Lenders duly and punctually to
                    observe and perform their respective obligations under the
                    Finance Documents;

          (e)       shall be responsible for the consequences of relying on the
                    advice of any professional advisers selected by any of them
                    in connection with the Finance Documents;

          (f)       shall be liable for acting (or refraining from acting) in
                    what it believes to be in the best interests of the Lenders
                    in circumstances where it has been unable, or it is not
                    practicable, to obtain the instructions of the Lenders or
                    the Majority Lenders (as the case may be); or

          (g)       shall be liable for anything done or not done by it under or
                    in connection with the Finance Documents save in the case of
                    its own negligence or wilful misconduct.

16.5      The Agent, the Security Agent and the Joint Arrangers Individually

16.5.1    If it is a Lender, each of the Agent, the Security Agent and each
          Joint Arranger shall have the same rights and powers under the Finance
          Documents as any other Lender and may exercise those rights and powers
          as if it were not also acting as Agent, Security Agent or Joint
          Arranger.

16.5.2    Each of the Agent, the Security Agent and each Joint Arranger may:-

          (a)       retain for its own benefit (and without liability to
                    account) any fee or other sum receivable by it for its own
                    account; and

          (b)       accept deposits from, lend money to, provide any advisory,
                    trust or other services to or engage in any kind of banking
                    or other business with any party to this Agreement, or any
                    subsidiary or affiliate of any party (and, in each case, may
                    do so without liability to account).

16.6      Communications and Information


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16.6.1    All communications to any member of the ChiRex Group are to be made by
          or through the Agent. Each Finance Party will notify the Agent of, and
          provide the Agent with a copy of, any communication between such
          Finance Party and the relevant member of the ChiRex Group or any other
          of the Finance Parties on any matter concerning the Facilities or the
          Finance Documents.

16.6.2    The Agent will not be obliged to transmit to the other Finance Parties
          any information in any way relating to any of the parties to the
          Finance Documents which the Agent may have acquired otherwise than in
          connection with the Facilities or the Finance Documents.

16.6.3    In acting as Agent for the Lenders, the Agent's banking division shall
          be treated as a separate entity from any other of its divisions (or
          similar unit of the Agent in any subsequent re-organisation),
          subsidiaries or affiliates (the "Other Divisions") and, in the event
          that the Agent should act for any member of the ChiRex Group in a
          corporate finance or other advisory capacity ("Advisory Capacity"),
          any information given by any of them to one of the Other Divisions is
          to be treated as confidential and will not be available to the Finance
          Parties without the consent of the person for whom the Agent is acting
          in an Advisory Capacity, provided that:-

          (a)       the consent of that person shall not be required in relation
                    to any information which the Agent in its discretion
                    determines relates to an Event of Default or a Potential
                    Event of Default or in respect of which the Lenders have
                    given a confidentiality undertaking in a form satisfactory
                    to the Agent and the Borrower or that person; and

          (b)       if representatives or employees of the Agent receive
                    information in relation to an Event of Default or a
                    Potential Event of Default while acting in an Advisory
                    Capacity they will not be obliged to disclose such
                    information to representatives or employees of the Agent in
                    their capacity as agent bank, security agent or joint
                    arranger hereunder or to any of the Lenders if to do so
                    would breach any rule or regulation or fiduciary duty
                    imposed upon such persons.

16.7      Non-Reliance on Agent, Security Agent or Joint Arrangers

          Each Lender confirms in favour of the Agent, Security Agent and Joint
          Arrangers that it is (and will at all


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          times continue to be) solely responsible for making its own
          independent investigation and appraisal of the business, operations,
          financial condition, creditworthiness, status and affairs of the
          ChiRex Group and has not relied, and will not at any time rely on the
          Agent or the Security Agent or the Joint Arrangers:-

16.7.1    to provide it with any information relating to the business,
          operations, financial condition, creditworthiness, status and affairs
          of the ChiRex Group, whether coming into its possession before or
          after the making of any Advance, except as otherwise specifically
          provided herein; or

16.7.2    to check or enquire into the adequacy, accuracy or completeness of any
          information provided by the ChiRex Group under or in connection with
          this Agreement or any other Finance Document (whether or not such
          information has been or is at any time circulated to it by the Agent),
          including, without limitation, that contained in the Information
          Memorandum; or

16.7.3    to assess or keep under review the business, operations, financial
          condition, creditworthiness, status or affairs of the ChiRex Group.

16.8      Indemnity to Agent, Security Agent and Joint Arrangers

16.8.1    Each Lender shall on demand fully indemnify the Agent, the Security
          Agent and the Joint Arrangers and their respective officers, employees
          and affiliates (collectively the "Agency Indemnitees") in the
          proportion which its Relevant Amount bears to the Relevant Amounts of
          all the Lenders at the relevant time against any cost, expense or
          liability sustained or incurred by any of the Agency Indemnitees in
          their respective capacities as Agent, Security Agent and Joint
          Arrangers as a consequence of or in connection with complying with any
          instructions from the Lenders or the Majority Lenders (as the case may
          be) or otherwise sustained or incurred in their respective capacities
          as Agent, Security Agent and Joint Arrangers in connection with the
          Finance Documents or its respective duties, obligations and
          responsibilities under the Finance Documents, except to the extent
          that they are sustained or incurred principally as a result of the
          negligence or wilful misconduct of such Agency Indemnitee as finally
          determined by a court having jurisdiction (the determination not being
          subject to appeal).

16.8.2    The provisions of Clause 16.8.1 are without prejudice to the
          obligations of the Borrower to indemnify the Agency


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          Indemnitees pursuant to Clause 27 and the Borrower will reimburse each
          Lender on demand for any payment made by that Lender pursuant to
          Clause 16.8.1.

16.9      Termination and Resignation of Agency: Appointment of Successor
 
16.9.1    The Agent may resign its appointment at any time by giving not less
          than 30 days' notice to the Lenders and the Borrower.

16.9.2    A successor Agent shall be selected:-

          (a)       by the retiring Agent (following consultation with the
                    Borrower) nominating one of its subsidiaries or affiliates
                    as successor Agent in its notice of resignation; or

          (b)       if the retiring Agent makes no such nomination, by the
                    Majority Lenders nominating one of the Lenders as successor
                    Agent (following consultation with the Borrower); or

          (c)       if the Majority Lenders have failed to nominate a successor
                    Agent within 30 days of the date of the retiring Agent's
                    notice of resignation, by the retiring Agent nominating a
                    financial institution of good standing to be the successor
                    Agent.

16.9.3    The resignation of the retiring Agent and the appointment of the
          successor Agent will only become effective upon the successor Agent
          accepting its appointment as Agent in writing at which time:-

          (a)       the successor Agent will become bound by all the obligations
                    of the Agent and become entitled to all the rights,
                    privileges, powers, authorities and discretions of the Agent
                    hereunder;

          (b)       the agency of the retiring Agent will terminate but without
                    prejudice to any liabilities which the retiring Agent may
                    have incurred or the indemnities to which the retiring Agent
                    may be entitled prior to the termination of its agency; and

          (c)       the retiring Agent will be discharged from any further
                    liability or obligation under or in connection with the
                    Finance Documents (save that the outgoing Agent shall pay to
                    the successor a pro rata proportion of the agency fee paid
                    under Clause 11.1.1(c)).


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16.9.4    The retiring Agent will co-operate with the successor Agent in order
          to ensure that its functions are transferred to the successor Agent
          without disruption to the service provided to the ChiRex Group and the
          Lenders and will promptly make available to the successor Agent such
          documents and records as have been maintained in connection with this
          Agreement in order that the successor Agent is able to discharge its
          functions.

16.9.5    The provisions of this Agreement will continue in effect for the
          benefit of any retiring Agent in respect of any actions taken or
          omitted to be taken by it or any event occurring before the
          termination of its agency.

16.10     Resignation of Security Agent

          The Security Agent may resign its appointment in exactly the same
          manner as set out in relation to the Agent in Clause 16.9 above except
          that the Security Agent's resignation shall not take effect until all
          necessary deeds and documents have been entered into in order to
          substitute its successor as holder of the security comprised in the
          Security Documents.

16.11     Payments to Finance Parties

16.11.1   The Agent will account to the other Finance Parties for their due
          proportion of all sums received by the Agent for such Finance Parties,
          whether by way of repayment of principal or payment of interest,
          commitment commission, fees or otherwise.

16.11.2   Save as otherwise specifically agreed between the Agent and the other
          Finance Parties in the case of any arrangement fee, the Agent may
          retain for its own use and benefit, and shall not be liable to account
          to the other Finance Parties for all or any part of, any sums received
          by it by way of agency fee or any other fee or by way of reimbursement
          of expenses incurred by it.

16.12     Change of Office of Agent, Security Agent or Joint Arrangers

          The Agent, the Security Agent and either Joint Arranger may at any
          time and from time to time in their respective sole discretion by
          written notice to the Borrower and each of the other Finance Parties
          designate a different office from which their respective duties as
          Agent,


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          Security Agent or Joint Arranger will thereafter be performed.

17.       EVIDENCE OF INDEBTEDNESS

          In any proceedings relating to this Agreement, a statement as to any
          amount due to any Finance Party under this Agreement which is
          certified as being correct by an officer of the Agent and a statement
          as to any amount due to a Finance Party under this Agreement which is
          certified as being correct by an officer of that Finance Party shall
          in the absence of manifest error, unless otherwise provided in this
          Agreement, be prima facie evidence of the amount so due and that such
          amount is in fact due and payable.

18.       APPLICATION OF MONEYS

          If any sum paid or recovered in respect of the liabilities of the
          Obligors under any of the Finance Documents is less than the amount
          then due, the Agent shall apply that sum in the following order:-

          (a)       first to any unpaid fees and reimbursement of unpaid
                    expenses of the Agent and the Security Agent;

          (b)       secondly to any unpaid fees and reimbursement of unpaid
                    expenses of the Lenders;

          (c)       thirdly to unpaid interest;

          (d)       fourthly to unpaid principal; and

          (e)       fifthly to other amounts due under the Finance Documents;

          in each case pro rata to the outstanding amounts owing to the Finance
          Parties under the Finance Documents taking into account any
          applications under this Clause 18.

19.       PRO RATA PAYMENTS

19.1      If any amount owing by any Obligor under any Finance Document to a
          Lender (the "Recovering Lender") is discharged by payment, set-off,
          use of cash collateral or any other manner other than through the
          Agent in accordance with Clause 9.1.1 (such amount being referred to
          in this Clause 19.1 as the "Recovery"), then:-


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          (a)       within two Business Days of receipt of the Recovery, the
                    Recovering Lender shall pay to the Agent an amount equal (or
                    equivalent) to such Recovery;

          (b)       the Agent shall treat such payment as if it were part of the
                    payment to be made by the Borrower to the Lenders rateably
                    in accordance with their respective Commitments; and

          (c)       save for any receipt by the Recovering Lender as a result of
                    the operation of paragraph (b) above, as between the members
                    of the ChiRex Group and the Recovering Lender the Recovery
                    shall be treated and deemed as not having been paid.

19.2      Each Lender shall notify the Agent promptly of any such Recovery by
          that Lender other than by payment through the Agent. If any Recovery
          subsequently has to be wholly or partly refunded by the Recovering
          Lender which paid an amount equal thereto to the Agent under Clause
          19.1(a), each Lender to which any part of that amount was distributed
          shall, on request from the Recovering Lender, repay to the Recovering
          Lender such Lender's pro rata share of the amount which has to be
          refunded by the Recovering Lender.

19.3      Each Lender shall on request supply to the Agent such information as
          the Agent may from time to time request for the purpose of this Clause
          19. Notwithstanding the foregoing provisions of this Clause 19, no
          Recovering Lender shall be obliged to share with another person any
          Recovery which it receives pursuant to legal proceedings taken by it
          to recover any sums owing to it under the Finance Documents where such
          other person has a legal right to, but does not, either join in such
          proceedings or commence and diligently pursue separate proceedings to
          enforce its rights in the same or another court (unless the
          proceedings instituted by the Recovering Lender are instituted by it
          without prior notice having been given to such other person through
          the Agent).

19.4      Failure by any Recovering Lender to comply with any of the provisions
          of this Clause 19 shall not release any other Recovering Lender from
          any of its obligations or liabilities under this Clause 19.

19.5      Each party to this Agreement agrees to take all steps required of it
          pursuant to Clause 19.1, and to use its reasonable endeavours to
          obtain any consents or authorisations which may at any relevant time
          be


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          required, for any payment by it pursuant to this Clause 19.

19.6      The provisions of this Clause 19 shall not, and shall not be construed
          so as to, constitute a charge by a Lender over all or any part of a
          sum received or recovered by it in the circumstances mentioned in this
          Clause 19.

20.       SET-OFF

          Any Finance Party may without notice to any members of the ChiRex
          Group, following the giving of notice by the Agent pursuant to Clause
          14.3, combine, consolidate or merge all or any of the accounts of any
          member of the ChiRex Group with, and liabilities to, that Finance
          Party and may set off or otherwise retain or transfer any sum standing
          to the credit of any such accounts in or towards the satisfaction of
          any of the liabilities of such member of the ChiRex Group to that
          Finance Party under the Finance Documents (whether or not such
          liabilities are then due for payment), and may do so notwithstanding
          that the balances on such accounts and the liabilities may not be
          expressed in the same currency, and each Finance Party is hereby
          authorised to effect any necessary conversions at the Agent's spot
          rate of exchange then prevailing.

21.       NOTICES

21.1      Save as specifically otherwise provided in this Agreement or agreed
          with the Agent any notice, demand or other communication to be served
          under this Agreement may be served upon any party hereto only by
          posting by first class (or air mail) post or by delivering the same in
          person or by courier or sending the same by facsimile transmission to
          the party to be served at its address or facsimile number given in the
          relevant Finance Document or at such other address or number as it may
          from time to time notify in writing to the other parties hereto. As
          regards the initial parties to this Agreement, their respective
          addresses and numbers are set out under their respective names in
          Schedule 1 or in the signature pages of this Agreement.

21.2      A notice or demand served by first class (or air mail) post shall be
          deemed duly served upon receipt, a notice or demand served in person
          or by courier shall be deemed duly served when delivered and a notice
          or demand sent by facsimile transmission shall be deemed to have been
          served at the time of transmission unless served on a


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          non-Business Day or after 5.00 p.m. at the place in which the
          recipient is located in which case it will be deemed served at 9.00
          a.m. at the place in which the recipient is located on the following
          Business Day.

21.3      In proving service of any notice or demand it will be sufficient to
          prove, in the case of a letter, that such letter was properly stamped
          or franked first class (or with appropriate air mail postage),
          addressed and placed in the post, in the case of a notice or demand
          served by courier that it was delivered by the courier company and, in
          the case of a facsimile transmission, that such facsimile was duly
          transmitted to a current facsimile number of the addressee at the
          address referred to above and the transmission report indicates that
          it was correctly sent and received.

22.       NO IMPLIED WAIVERS

22.1      No failure or delay by the Agent, the Security Agent or the Joint
          Arrangers or any other Finance Party in exercising any right, power or
          privilege under any of the Finance Documents shall operate as a waiver
          thereof nor shall any single or partial exercise of any right, power
          or privilege preclude any further exercise thereof or the exercise of
          any other right, power or privilege.

22.2      The rights and remedies provided in the Finance Documents are
          cumulative and not exclusive of any rights and remedies provided by
          law and all such rights and remedies howsoever arising will, save
          where expressly provided to the contrary therein, be available to the
          Finance Parties severally and any Finance Party shall be entitled to
          commence proceedings in connection therewith in its own name.

23.       INVALIDITY OF ANY PROVISION

          If any of the provisions of this Agreement become invalid, illegal or
          unenforceable in any respect under any law, the validity, legality and
          enforceability of the remaining provisions shall not in any way be
          affected or impaired.

24.       CONFIDENTIALITY

24.1      Each of the Finance Parties agrees with the Borrower to hold
          confidential all information which they acquire


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          under or in connection with the Finance Documents save to the extent
          they are required by law or regulation, or are requested by any
          regulator with jurisdiction over, or over any business of, the
          relevant Finance Party or any of its subsidiaries or affiliates, or
          where necessary in connection with litigation, to disclose the same or
          the same comes into the public domain (otherwise than as a result of a
          breach of this Clause 24).

24.2      Nothing in Clause 24.1 shall restrict any Finance Party from
          disclosing information in accordance with Clause 25.4 (Disclosure of
          Information).

24.3      Except to the extent required by law, all public announcements in
          relation to this Agreement shall be made through the Agent. The Agent
          will not make any written public announcement in relation to this
          Agreement without first having the text of the announcement approved
          by ChiRex Inc. (such approval not to be unreasonably withheld or
          delayed).

25.       CHANGES TO PARTIES

25.1      No Assignment by the ChiRex Group

          None of the members of the ChiRex Group may assign or transfer all or
          part of their rights or obligations under this Agreement or any of the
          other Finance Documents.

25.2      Lenders

25.2.1    A Lender (a "Transferor") may at any time, following consultation with
          the Borrower, assign or otherwise transfer (together, "Transfer") all
          or any part of its rights or obligations under the Finance Documents
          to any person which is then a Qualifying Lender (a "Transferee"),
          subject to the other terms of this Clause 25, provided that unless the
          Borrower and the Agent otherwise agree, any Transfer by a Transferor
          (i) in relation to all Facilities other than a WCP Facility, must, to
          the extent it has rights and/or obligations in respect of one or more
          Facility, be in relation to all Facilities and any Transfer shall be
          for the same proportion of the Transferor's rights and obligations in
          each Facility, and (ii) in relation to a WCP Facility must be in
          respect of that entire WCP Facility and that Transferor's entire WCP
          Commitment thereunder.

25.2.2    A Transfer of obligations of the Lenders shall only be effective if
          made in accordance with Clause 25.3


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          (Substitution Provisions) or if the Transferee has, prior to the
          Transfer taking effect, confirmed in writing to the Agent (acting on
          behalf of all the other Lenders) and to the Borrower that it
          undertakes to be bound by the terms of each of the Finance Documents
          binding upon it as a Lender in form and substance satisfactory to the
          Agent. On any such Transfer being made, the Transferor shall be
          relieved of its obligations to the extent that they are transferred to
          the Transferee.

25.3      Substitution Provisions

25.3.1    A Transferor may transfer, upon notice being given by the Agent to the
          other parties hereto as provided below, all or any of its rights and
          obligations under the Finance Documents to a Transferee by means of a
          novation effected by the Agent executing a Transfer Certificate which
          has been duly completed and signed on behalf of both the Transferee
          and the Transferor. For the avoidance of doubt, the Agent shall not be
          obliged to execute a Transfer Certificate unless the identity of the
          Transferee named therein is satisfactory to the Agent, and nothing in
          this Clause 25.3.1 shall be deemed to authorise the Agent to sign a
          Transfer Certificate which has not been signed on behalf of a
          Transferee and Transferor.

25.3.2    On the later of (i) the date specified in the Transfer Certificate as
          being the date on or as from which the substitution under this Clause
          25.3 is to take effect and (ii) the date on which the Agent executes
          the Transfer Certificate, the following shall occur:-

          (a)       to the extent that in the Transfer Certificate the
                    Transferor seeks to transfer its rights and obligations
                    under the Finance Documents, the members of the ChiRex Group
                    and the Transferor shall each be released from further
                    obligations to each other under the Finance Documents (and
                    the appropriate reduction shall be made to the Commitment of
                    the Transferor) and their respective rights against each
                    other shall be cancelled (such rights and obligations beings
                    referred to in this Clause 25.3.2 as "Discharged Rights and
                    Obligations");

          (b)       the members of the ChiRex Group and the Transferee shall
                    each assume obligations towards each other and acquire
                    rights against each other which differ from the Discharged
                    Rights and Obligations only in so far as the members of the
                    ChiRex Group and such Transferee have assumed and acquired
                    the same in


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                    place of the members of the ChiRex Group and the Transferor;

          (c)       the Agent, the Security Agent, the Joint Arrangers, the
                    Transferee and the other Lenders shall acquire the same
                    rights and assume the same obligations between themselves as
                    they would have acquired and assumed had the Transferee been
                    an original party hereto as a Lender with the rights and
                    obligations acquired or assumed by it as a result of the
                    novation; and

          (d)       on the date upon which such transfer takes effect, the
                    Transferee shall pay to the Agent for its own account a
                    transfer fee of GBP 500, except that no fee shall be payable
                    in respect of a transfer which occurs not later than six
                    months after the Initial Drawdown Date.

25.3.3    Nothing in this Agreement or any other Finance Document shall oblige a
          Transferor or cause a Transferor to be liable:-

          (a)       to accept a re-assignment or re-transfer from a Transferee
                    of any of the rights or obligations assigned, transferred or
                    novated pursuant to this Clause 25; or

          (b)       to support any losses incurred by a Transferee by reason of
                    the non-performance by any member of the ChiRex Group of
                    their obligations under any of the Finance Documents.

25.3.4    Each of the parties hereto (other than the Transferor and the
          Transferee) authorises the Agent to execute on its behalf any Transfer
          Certificate which has been duly completed in accordance with this
          Clause 25.3 and executed on behalf of each of the Transferor and the
          Transferee.

25.3.5    The Agent shall promptly notify the other parties hereto of the
          receipt and execution by it on their behalf of any Transfer
          Certificate and shall supply a copy of the Transfer Certificate to the
          Borrower.

25.4      Disclosure of Information

          Each Lender may disclose to a proposed assignee or transferee or any
          sub-participant, risk participant or other participant proposing to
          enter or having entered into a contract with such Lender regarding the
          Finance Documents any information in the possession of such


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          Lender relating to the ChiRex Group (and any member of it) as it sees
          fit subject to such person agreeing in writing to be bound by the
          confidentiality provisions set out in Clause 24.

25.5      The Agent and the Reference Lenders

25.5.1    Changes to the Agent and the office through which the Agent acts may
          be effected pursuant to Clauses 16.9 and 16.12 respectively.

25.5.2    If a Reference Lender ceases to be one of the Lenders or, if a
          Reference Lender is not itself a Lender but an affiliate of a Lender
          and such Lender ceases to be one of the Lenders, then:-

          (a)       the Lender or, as the case may be, affiliate of the Lender
                    concerned shall cease to be a Reference Lender; and

          (b)       the Agent shall in consultation with the Borrower appoint
                    another Lender or an affiliate of another Lender to be a
                    Reference Lender.

26.       LENDER DECISIONS

26.1      Subject to Clauses 26.2 and 26.3, any provision of this Agreement or
          any of the other Finance Documents may be amended, waived, varied or
          modified with the agreement of the Majority Lenders.

26.2      The following matters shall require the unanimous agreement of all of
          the Lenders:-

26.2.1    any increase in any Commitment of any Lender;

26.2.2    any extension of any scheduled date for payment of any sum due, owing
          or payable to any Lender;

26.2.3    any reduction in the amount, or change in currency, of any payment of
          principal, interest, fees or commissions or other amounts payable
          hereunder by any party;

26.2.4    any amendment, variation or modification of this Clause 26, Clause 19
          (Pro Rata Payments), Clause 20 (Set-off), Clause 25.1 (Assignment by
          the Borrower, Etc.) or to the definition of Majority Lenders;


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26.2.5    any matter which, by the terms of this Agreement as at the date
          hereof, is stated to be subject to the consent of all Lenders;

26.3      Any amendment, waiver, variation or modification of Clause 16 (The
          Agent and the other Finance Parties) may not be effected without the
          agreement of the Agent (giving effect to Clause 16.1.4).

26.4      Subject to any provision of the Finance Documents entitling or
          obliging the Agent or the Security Agent to grant releases or permit
          any disposal to take place, any question which relates to the release
          or material variation of any security held by the Security Agent shall
          require the agreement of the Majority Lenders, failing which no such
          release or variation may be effected.

27.       INDEMNITIES

27.1      General Indemnity and Breakage Costs

          The Borrower will fully indemnify each of the Finance Parties, and
          their respective officers, employees, subsidiaries and affiliates
          (collectively the "Finance Indemnitees") from and against any expense,
          loss, damage or liability (including without limitation any arising
          from any actual or alleged breach of any Environmental Laws) which any
          of the Finance Indemnitees may incur as a consequence of or in
          connection with (i) the provision and/or Syndication of the Facilities
          or the use of proceeds thereof (including the distribution of the
          Information Memorandum), or (ii) the execution, delivery or
          performance of any of the Finance Documents, other than, in the case
          of a Finance Indemnitee, any such expense, loss, damage or liability
          which is finally determined by a court having jurisdiction (the
          determination not being subject to appeal) to have resulted
          principally from the negligence or wilful misconduct of such Finance
          Indemnitee or which is otherwise reimbursed by a member of the ChiRex
          Group under the Finance Documents. The Borrower will further fully
          indemnify each of the Finance Parties from and against any expense,
          loss, damage or liability which they may incur as a consequence of any
          failure to pay any sum due pursuant to the Finance Documents when due,
          or any failure to borrow when obliged to do so in accordance with this
          Agreement (including without limitation failure to satisfy any
          conditions precedent to such borrowing) or repaying an Advance
          otherwise than on the last day of an


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          Interest Period or otherwise in connection with a breach by ChiRex
          Inc. or any member of the ChiRex Group of this Agreement or of any
          Finance Document, except where it is otherwise reimbursed by a member
          of the ChiRex Group under the Finance Documents. Without prejudice to
          its generality, the indemnity in the preceding sentence extends to any
          interest, fees or other sums whatsoever paid or payable on account of
          any funds borrowed in order to carry any amount which a member of the
          ChiRex Group fails to pay in breach of this Agreement and to any loss
          (including loss of profit), premium, penalty or expenses which may be
          incurred in liquidating or employing deposits from third parties
          acquired to make, maintain or fund outstanding Advances or any other
          amount due or to become due under this Agreement.

27.2      Currency Indemnity

          Without prejudice to Clause 27.1, if:-

27.2.1    any amount payable by any Obligor under or in connection with any
          Finance Document is received by any Finance Party in a currency (the
          "Payment Currency") other than that agreed in the relevant Finance
          Document (the "Agreed Currency"), whether as a result of any
          judgement, decree or order or the enforcement thereof, the liquidation
          of that member or otherwise; and

27.2.2    the amount produced by converting the Payment Currency so received
          into the Agreed Currency is less than the relevant amount of the
          Agreed Currency;

          then the relevant Obligor shall, as an independent obligation,
          indemnify the relevant Finance Party for the deficiency and any loss
          sustained as a result. Such conversion shall be made at such
          prevailing rate of exchange, on such date and in such market as is
          determined by the relevant Finance Party as being most appropriate for
          the conversion. The relevant Obligor shall in addition pay the costs
          of the conversion as an independent and joint and several obligation.

27.3      Waiver

          Each Obligor waives any right it may have in any jurisdiction to pay
          any amount under any Finance Document in a currency other than that in
          which it is expressed to be payable in the relevant Finance Document.

28.       CERTIFICATES CONCLUSIVE


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          A certificate, determination, notification or opinion of a Finance
          Party, the Majority Lenders or any Lender provided for in any Finance
          Document shall be conclusive save in the case of manifest error.

29.       GOVERNING LAW

          This Agreement shall be governed by and construed in accordance with
          the laws of England.

30.       JURISDICTION

30.1      Submission

          For the benefit of each Finance Party, each Obligor agrees that the
          courts of England shall have jurisdiction to settle any disputes in
          connection with any Finance Documents and accordingly submits to the
          jurisdiction of the English courts.

30.2      Service of Process

          Without prejudice to any other mode of service, each Obligor:-

          (a)       irrevocably appoints the Borrower as its agent for service
                    of process relating to any proceedings before the English
                    courts in connection with any Finance Document;

          (b)       agrees that failure by a process agent to notify it of the
                    process will not invalidate the proceedings concerned; and

          (c)       (without prejudice to other forms of service permitted by
                    law) consents to the service of process relating to any such
                    proceedings by prepaid posting of a copy of the process to
                    its address for notices to it from time to time under Clause
                    21 (Notices).

          (d)       The Borrower irrevocably accepts its appointment as agent
                    for service of process under the Finance Documents as set
                    forth in sub-clause (a).

30.3      Forum Convenience and Enforcement Abroad

          Each Obligor:-


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          (a)       waives objection to the English courts on grounds of
                    inconvenient forum or otherwise as regards proceedings in
                    connection with a Finance Document; and

          (b)       agrees that a judgement, decree or order of an English court
                    or other court in connection with a Finance Document is
                    (subject to rights of appeal before the English courts or
                    such other courts) conclusive and binding on it and may be
                    enforced against it in the courts of any other jurisdiction.

30.4      Non-Exclusivity

          Nothing in this Clause 30 limits the right of a Finance Party to bring
          proceedings against any Obligor in connection with any Finance
          Document:-

          (a)       in any other court of competent jurisdiction; or

          (b)       concurrently in more than one jurisdiction.

31.       COUNTERPARTS

          This Agreement may be executed in any number of counterparts and all
          of such counterparts taken together shall be deemed to constitute one
          and the same instrument.

                  [Remainder of page intentionally left blank]


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CHIREX (HOLDINGS) LIMITED, in its capacity as the Borrower


By: /s/ Michael A. Griffith
   -----------------------------------

Print Name: Michael A. Griffith
           ---------------------------

Title: Chief Financial Officer
      --------------------------------

CHIREX INC., in its capacity as a Guarantor


By: /s/ Michael A. Griffith
   -----------------------------------

Print Name: Michael A. Griffith
           ---------------------------

Title: Chief Financial Officer
      --------------------------------

CHIREX (DUDLEY) LIMITED, in its capacity as a Guarantor


By: /s/ Michael A. Griffith
   -----------------------------------

Print Name: Michael A. Griffith
           ---------------------------

Title: Chief Financial Officer
      --------------------------------

CHIREX (ANNAN) LIMITED, in its capacity as a Guarantor


By: /s/ Michael A. Griffith
   -----------------------------------

Print Name: Michael A. Griffith
           ---------------------------

Title: Chief Financial Officer
      --------------------------------


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BANKERS TRUST INTERNATIONAL PLC, in its capacity as a Joint
Arranger


By: /s/ Elene A. Harkavy
   -----------------------------------

Print Name: Elene A. Harkavy
           ---------------------------

Title: Vice President
      --------------------------------

MIDLAND BANK PLC, in its capacity as a Joint Arranger and a
Lender


By: /s/ Keith Taylor
   -----------------------------------

Print Name: Keith Taylor
           ---------------------------

Title: Senior Business Banking Manager
      --------------------------------

BANKERS TRUST COMPANY, in its capacities as a Lender, Agent and
Security Agent


By: /s/ Elene A. Harkavy
   -----------------------------------

Print Name: Elene A. Harkavy
           ---------------------------

Title: Vice President
      --------------------------------


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                                   SCHEDULE 1

                         Commitments and Lending Offices
                         -------------------------------

           Names and Addresses of
                     Initial Lenders                               Commitment
           ------------------------------------------------------------------
                                                                    GBP

           BANKERS TRUST COMPANY                                   31,000,000
           1 Appold Street
           London EC2A 1HE

           Attn.                                             Barry  Jefferies
           Tel:     +44 171 982 2500
           Fax:     +44 171 982 2271

           MIDLAND BANK PLC                                        31,000,000
           50 Grey Street
           Newcastle upon Tyne
           NE99 1SA

           Attn.                                                 Keith Taylor
           Tel:     +44 191 220 6127
           Fax:     +44 191 220 6197


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                                   SCHEDULE 2

                               Repayment Schedule
                               ------------------

                                                           Scheduled Repayment
           Repayment Date                                    of Term Loans
           ---------------------- --------------------------------------------
                                                                 GBP

           31st December, 1998                                4,444,444.44
           30th June, 1999                                    4,444,444.44
           31st December, 1999                                4,444,444.44
           30th June, 2000                                    4,444,444.44
           31st December, 2000                                4,444,444.44
           30th June, 2001                                    4,444,444.44
           31st December, 2001                                4,444,444.44
           30th June, 2002                                    4,444,444.44
           31st December, 2002                                4,444,444.48


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                                   SCHEDULE 3

                            Form of Drawdown Request

To: [Insert details of Agent's administrations department]

Attn:
         [            ]

GBP 62,000,000 facilities agreement dated [
   ], 1997

We refer to the above agreement between, inter alia, ourselves, the Arrangers,
the Lenders described therein and yourselves as Agent (as heretofore amended,
the "Facilities Agreement", which expression includes any amendments or
supplements thereto or restatements thereof). Terms defined in the Facilities
Agreement have the same meaning in this notice.

Pursuant to Clause 5.1 of the Facilities Agreement, we hereby give you notice of
the following proposed drawing of an Advance under the [Tranche A Term Facility]
[Tranche B Multicurrency Revolving Facility]:

(a)       Proposed Drawdown Date (a Business Day):

(b)       Currency [GBP only if Tranche A Facility; USD, DEM, FF LIT, CHF, Yen
          and GBP if Tranche B Facility]:

(c)       Amount:

(d)       Duration of first Interest Period:

(e)       Payment instructions:

(f)       Purpose:

We confirm that no Event of Default or Potential Event of Default has occurred
and is continuing unremedied or unwaived or will occur as a result of making
this Advance and that each of the representations and warranties required to be
made in accordance with Clause 12 of the Facilities Agreement is true and
accurate on the date hereof.

Dated: _____________


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[BORROWER]


By:
   ---------------------------

Its:
    --------------------------

Notes

(1)       No more than fifteen separate Tranche B Revolving Advances may be
          outstanding at any one time.

(2)       Currencies other than USD, DEM, FF, LIT, CHF, Yen and GBP may not be
          requested unless the Agent has confirmed in writing to the Borrower
          that such other currency is freely available to all the Lenders and is
          one in which dealings regularly occur in the London interbank market.

(3)       These notes are included for convenience only and are to be ignored in
          construing the Facilities Agreement.


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                                   SCHEDULE 4

                            Structure of ChiRex Group

                                [GRAPHIC OMITTED]


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<PAGE>   140

                                   SCHEDULE 5

                 Calculation of the Mandatory Liquid Asset Costs
                            for any Sterling Advances

(a)       The Mandatory Liquid Asset Costs for an Advance if denominated in GBP
          for each Interest Period for that Advance is calculated in accordance
          with the following formula:

                  BY + L(Y-X) + S(Y-Z)
                  -------------------
          % PER ANNUM
                          100 - (B+S)

          where on the day of the application of the formula:

          B         is the percentage of the Agent's eligible liabilities which
                    the Bank of England then requires the Agent to hold on a
                    non-interest-bearing deposit account in accordance with its
                    cash ratio requirements;

          Y         is the rate at which GBP deposits are offered by the Agent
                    to leading banks in the London interbank market at or about
                    11.00 a.m. on that day for the relevant period;

          L         is the percentage of eligible liabilities which (as a result
                    of the requirements of the Bank of England) the Agent
                    maintains as secured money with members of the London
                    Discount Market Association or in certain marketable or
                    callable securities approved by the Bank of England, which
                    percentage shall (in the absence of evidence that any other
                    figure is appropriate) be conclusively presumed to be 5 per
                    cent.;

          X         is the rate at which secured GBP deposits may be placed by
                    the Agent with members of the London Discount Market
                    Association at or about 11.00 a.m. on that day for


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<PAGE>   141

                    the relevant period or, if greater, the rate at which GBP
                    bills of exchange (of a tenor equal to the duration of the
                    relevant period) eligible for rediscounting at the Bank of
                    England can be discounted in the London Discount Market at
                    or about 11.00 a.m. on that day;

          S         is the percentage for the Agent's eligible liabilities which
                    the Bank of England requires the Agent to place as a special
                    deposit; and

          Z         is the interest rate per annum allowed by the Bank of
                    England on special deposits.

(b)       For the purposes of this Schedule:

          (i)       "eligible liabilities" and "special deposits" have the
                    meanings given to them at the time of application of the
                    formula by the Bank of England; and

          (ii)      "relevant period" in relation to each Interest Period means:

                    (A)       if it is 3 months or less, that Interest Period or

                    (B)       if it is more than 3 months, 3 months.

(c)       In the application of the formula, B, Y, L, X, S and Z are included in
          the formula as figures and not as percentages, e.g. if B=0.5% and Y =
          15%, BY would be calculated as 0.5 x 15.

(d)       The formula is applied on the first day of each relevant period. Each
          amount is rounded up to the nearest one- sixteenth of one per cent.

(e)       If the Agent determines that a change in circumstances has rendered,
          or will render, the formula inappropriate, the Agent (after
          consultation with the Lenders) shall notify the Borrower of the manner
          in which the Mandatory Liquid Asset Costs for such


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          Advances will subsequently be calculated. The manner of calculation so
          notified by the Agent shall, in the absence of manifest error, be 
          binding on all the Obligors.


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<PAGE>   143

                                   SCHEDULE 6

                            Form of Deed of Accession

THIS DEED is made this [ ] day of __________, by [ ], as Guarantor, IN FAVOUR
OF:

(1)       CHIREX (HOLDINGS) LIMITED (the "Borrower")

(2)       BANKERS TRUST INTERNATIONAL PLC AND MIDLAND BANK PLC as Joint
          Arrangers;

(3)       BANKERS TRUST COMPANY, as Agent (the "Agent");

(4)       BANKERS TRUST COMPANY, as Security Agent;

(5)       THE LENDERS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW; and

(6)       THE OBLIGORS PARTY TO THE FACILITIES AGREEMENT DESCRIBED BELOW.

WHEREAS:

(A)       This Deed is supplemental to a facilities agreement (the "Facilities
          Agreement", which expression includes any amendments or supplements
          thereto or restatements thereof) dated __ October, 1997 made among the
          parties referred to in paragraphs (1) to (6) above.

(B)       [insert name of party] wishes to accede to the Facilities Agreement as
          a Guarantor.

NOW THIS DEED WITNESSETH AS FOLLOWS:

(1)       Words and expressions defined in the Facilities Agreement shall have
          the same meanings when used herein.

(2)       [insert name of Guarantor] hereby:

          (a)       agrees to be bound by all the terms and conditions of the
                    Facilities Agreement insofar as they relate to a Guarantor
                    (including without limitation Clause 15 (Guarantee) and
                    Clause 30 (Jurisdiction) of the


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<PAGE>   144

                    Facilities Agreement) as if it were a party to the
                    Facilities Agreement in such capacity; and

          (b)       represents and warrants to the Agent and the other Finance
                    Parties in the terms of the Facilities Agreement

(3)       The undersigned Guarantor agrees to be bound by all the terms and
          conditions of the Facilities Agreement insofar as they relate to an
          Obligor as if it were a party to the Facilities Agreement in such
          capacity.

(4)       [The foregoing notwithstanding, the obligations of the undersigned
          Guarantors under the foregoing shall be limited as follows:

          [limitations to guarantees, if not already in Facilities Agreement, to
          the extent required by applicable law]

(5)       The undersigned Guarantor confirms that its address for the purposes
          of Clause 21 (Notices) of the Facilities Agreement is set out under
          its name as follows:

          [Name]
          [Address]

          Attention:                             [
          ]
          Facsimile:                             [
          ]

(6)       Each of the undersigned hereby agrees that [insert name of Guarantor]
          shall, from the date of the later of (i) the execution by Agent of
          this Deed and (ii) the execution by Borrower of this Deed, accede to
          the Facilities Agreement as if it were a Guarantor and an Obligor
          named therein and a party thereto.

(7)       This Deed may be executed in any number of counterparts and all of
          such counterparts taken together shall be deemed to constitute one and
          the same instrument.

(8)       This Deed shall be governed by and construed in accordance with the
          laws of England.


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<PAGE>   145

IN WITNESS WHEREOF the undersigned have caused this Deed to be duly executed and
delivered the day and year first above written.

EXECUTED and DELIVERED                      )
as a deed                                   )
for and on behalf of                        )
[                ]                          )
by                                          )
in the presence of                          )

EXECUTED and DELIVERED                      )
as a deed                                   )
for and on behalf of                        )
[             ]                             )
as Borrower                                 )
by [             ]                          )
in the presence of:                         )

SIGNED by
for and on behalf of
BANKERS TRUST COMPANY,
as Agent

 .............................................
Date:


                                     S6 - 3
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<PAGE>   146

                                   SCHEDULE 7

                          Form of Transfer Certificate

[Note: the Transferor and Transferee should ensure that all regulatory
requirements (in particular compliance with the Financial Services Act of 1986
and any regulations made thereunder) are satisfied in connection with their
entry into of their Transfer Certificate.]

TRANSFER CERTIFICATE

To:       [name of Agent]
          for and on behalf of the Borrower, the other Obligors, the
          Lenders and the other Finance Parties (each as defined in the
          Facility Agreement referred to below).

From:     [insert name of Transferor] (the "Transferor")

          [insert name of Transferee] (the "Transferee")

This transfer certificate (this "Certificate") relates to a Facilities Agreement
dated [ ] 1997, and made among Bankers Trust Company, as Agent and the Lenders
and Arrangers, described therein (the "Facilities Agreement", which expression
includes any amendments or supplements thereto or restatements thereof). Terms
defined in the Facilities Agreement shall, unless otherwise defined in this
Certificate, have the same meanings when used in this Certificate.

(1)       The Transferor by its execution of this Certificate:-

          (a)       confirms that the details which appear in column II of the
                    First Schedule of this Certificate accurately state,
                    respectively, the amount of the Transferor's Commitment and
                    the Transferor's participation in Advances as at the date of
                    this Certificate;

          (b)       requests the Transferee to accept and procure, in accordance
                    with Clause [24.3] of the Facilities Agreement, transfer to
                    the Transferee of the portion of the Transferor's
                    participation in the Facility specified in column III of the
                    First Schedule of this Certificate by counter-signing


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<PAGE>   147

                    this Certificate and delivering it to the Agent at its
                    address for the giving of notices under the Facility
                    Agreement so as to take effect on the date specified in the
                    Second Schedule of this Certificate (the "Transfer Date").

(2)       The Transferee by its execution of this Certificate requests the
          Obligors, the Lenders, the Agent and the other Finance Parties to
          accept this Certificate as being delivered under and for the purposes
          of Clause [25.3] of the Facilities Agreement so as to take effect in
          accordance with the terms of that Clause on the Transfer Date.

(3)       The Transferee undertakes to pay to the Agent for the Agent's own
          account a transfer fee of [USD ________] as provided in Clause
          [25.3.2(d)] of the Facility Agreement.

(4)       The Transferee hereby:

          (a)       confirms that it has received from the Transferor a copy of
                    the Facilities Agreement together with such other documents
                    and information as it has requested in connection with this
                    transaction;

          (b)       confirms that it has not relied, and will not hereafter
                    rely, on the Transferor or any other Finance Party to the
                    Facilities Agreement or any of the other Finance Documents
                    to check or enquire on its behalf into the legality,
                    validity, effectiveness, adequacy, accuracy or completeness
                    of any such documents or information;

          (c)       agrees that it has not relied, and will not hereafter rely,
                    on the Transferor or any other Finance Party to the
                    Facilities Agreement or any of the other Finance Documents
                    to assess or keep under review on its behalf the financial
                    condition, creditworthiness, condition, affairs, status or
                    nature of the Borrower, the other Obligors or any other
                    party to the Facilities Agreement or the other Finance
                    Documents; and


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          (d)       represents and warrants to the Transferor and all other
                    parties to the Facilities Agreement that it (i) has power to
                    become a party to the Facilities Agreement as a "Lender" on
                    the terms herein and therein set out, and (ii) has taken all
                    necessary steps to authorise execution and delivery of this
                    Certificate.

(5)       Neither the Transferor nor any other Finance Party to the Facilities
          Agreement makes any representation or warranty nor assumes any
          responsibility with respect to the legality, validity, effectiveness,
          adequacy or enforceability of the Finance Documents and assumes no
          responsibility for the financial condition of the Borrower, the other
          Obligors or any other party to the Finance Documents or for the
          performance and observance by the Borrower or any other Obligor of any
          of its obligations under the Finance Documents and any and all such
          representations and warranties and responsibility, whether express or
          implied by law or otherwise, are hereby excluded.

(6)       On execution of this Certificate by the Agent for itself and on behalf
          of the Obligors, the Lenders (other than the Transferor) and the other
          Finance Parties, each of them accepts the Transferee on and with
          effect from the Transfer Date as a party in substitution for the
          Transferor with respect to all those rights and obligations which by
          the terms of the Facilities Agreement, the other Finance Documents and
          this Certificate are assumed by the Transferor.

(7)       By its execution hereof, the Transferee confirms the appointment of
          [insert name of Agent] to act as its agent under and in connection
          with the Finance Documents and irrevocably authorises the Agent and
          for and on its behalf to exercise such rights, powers and discretions
          as are delegated to it by the terms of the Finance Documents, together
          with all such rights, powers and discretions as are incidental
          thereto, and to give a good discharge for any moneys payable under the
          Finance Documents.

(8)       This Certificate and the rights and obligations of the parties hereto
          shall be governed by and construed in accordance with English law.


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<PAGE>   149

AS WITNESS the hands of authorised signatories for and on behalf of the
Transferor, the Transferee and the Agent on the respective dates appearing
below.


                                     S7 - 4
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<PAGE>   150

                   First Schedule to the Transfer Certificate


         I                         II                            III
 Facility Details          Transferor Position              Position to be
  to Transferee             Prior to Transfer                Transferred


[                 ]       [                   ]          [                   ]
[                 ]       [                   ]          [                   ]
[                 ]       [                   ]          [                   ]
[                 ]       [                   ]          [                   ]


                                     S7 - 5
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<PAGE>   151

                   Second Schedule to the Transfer Certificate

Particulars relating to the Transferee

Transfer Date                  :
Lending Office                 :
Contact Name                   :
Account for Payments
                               :
Telephone                      :
Facsimile                      :

[Transferor]                                                   [Transferee]


By:..............................

By:..............................

Date: [                     ]                                  Date: [         ]


[Agent]

By:..............................


                                     S7 - 6
                                                                   Executed Copy
<PAGE>   152

                                   SCHEDULE 8

                             Continuing Indebtedness

                                      NONE

                                                                   Executed Copy

<PAGE>   1

            This PLEDGE AGREEMENT (this "Agreement") is dated as of __________
1997 and entered into by and between ChiRex Inc., (the "Pledgor"), and Bankers
Trust Company, as security agent for and representative of (in such capacity
herein called "Secured Party") the financial institutions ("Lenders") party to
the Facilities Agreement (as defined below).

                             PRELIMINARY STATEMENTS

                  A. Pledgor is the legal and beneficial owner of (i) the shares
of stock (the "Pledged Shares") described in Part A of Schedule I annexed hereto
and issued by the corporations named therein and (ii) the indebtedness (the
"Pledged Debt") described in Part B of said Schedule I and issued by the
obligors named therein.

                  B. Pledgor, Secured Party, Bankers Trust International PLC and
Midland Bank plc as joint arrangers, Bankers Trust Company as Agent, the Lenders
party thereto and certain other parties have entered into a Facilities Agreement
dated as of __________, 1997 (as it may hereafter be amended, supplemented or
otherwise modified from time to time, being the "Facilities Agreement",
capitalised terms used herein and not otherwise defined shall have the meanings
set forth in the Facilities Agreement) with, among others, the Borrower and the
Pledgor pursuant to which Lenders have made certain commitments, subject to the
terms and conditions set forth in the Facilities Agreement, to extend certain
credit facilities to the Borrower.

                  C. The Pledgor has guarantied the prompt payment and
performance when due of all obligations of all Obligors under the Facilities
Agreement.

                  D. It is a condition precedent to the initial extensions of
credit by Lenders under the Facilities Agreement that the Pledgor shall have
granted the security interests and undertaken the obligations contemplated by
this Agreement.

            NOW, THEREFORE, in consideration of the premises and in order to
induce Lenders to make the Advances and other extensions of credit under the
Facilities Agreement, and for other good and valuable consideration, the receipt
and adequacy of which are hereby acknowledged, the Pledgor hereby agrees with
Secured Party as follows:

            SECTION 1. Pledge of Security. Pledgor hereby pledges and assigns to
Secured Party, and hereby grants to 


                                        1
<PAGE>   2

Secured Party a security interest in, all of Pledgor's right, title and interest
in and to the following, in each case whether now or hereafter existing or in
which Pledgor now has or hereafter acquires an interest and wherever the same
may be located (the "Pledged Collateral"):

            (a) the Pledged Shares and the certificates representing the Pledged
Shares and any interest of Pledgor in the entries on the books of any financial
intermediary pertaining to the Pledged Shares, and all dividends, cash,
warrants, rights, instruments and other property or proceeds from time to time
received, receivable or otherwise distrib uted in respect of or in exchange for
any or all of the Pledged Shares;

            (b) all additional shares of, and all securities convertible into
and warrants, options and other rights to purchase or otherwise acquire, stock
of any issuer of the Pledged Shares from time to time acquired by Pledgor in any
manner (which shares shall be deemed to be part of the Pledged Shares), the
certificates or other instruments representing such additional shares,
securities, warrants, options or other rights and any interest of Pledgor in the
entries on the books of any financial intermediary pertaining to such additional
shares, and all dividends, cash, warrants, rights, instruments and other
property or proceeds from time to time received, receivable or otherwise
distributed in respect of or in exchange for any or all of such additional
shares, securities, warrants, options or other rights;

            (c) all shares of, and all securities convertible into and warrants,
options and other rights to purchase or otherwise acquire, stock of any person
that, after the date of this Agreement, becomes, as a result of any occurrence,
a direct subsidiary of Pledgor (which shares shall be deemed to be part of the
Pledged Shares), the certificates or other instruments representing such shares,
securities, warrants, options or other rights and any interest of Pledgor in the
entries on the books of any financial intermediary pertaining to such shares,
and all dividends, cash, warrants, rights, instruments and other property or
proceeds from time to time received, receivable or otherwise distributed in
respect of or in exchange for any or all of such shares, securities, warrants,
options or other rights;

            (d) the Pledged Debt and the instruments evidenc ing the Pledged
Debt, and all interest, cash, instruments and other property or proceeds from
time to time received, receivable or otherwise distributed in respect of or in
exchange for any or all of the Pledged Debt;


                                        2
<PAGE>   3

            (e) all additional indebtedness from time to time owed to Pledgor by
any obligor on the Pledged Debt and the instruments evidencing such
indebtedness, and all interest, cash, instruments and other property or proceeds
from time to time received, receivable or otherwise distributed in respect of or
in exchange for any or all of such indebted ness;

            (f) all indebtedness from time to time owed to Pledgor by any person
that, after the date of this Agreement, becomes, as a result of any occurrence,
a direct or indirect Subsidiary of Pledgor, and all interest, cash, instruments
and other property or proceeds from time to time received, receivable or
otherwise distributed in respect of or in exchange for any or all of such
indebtedness; and

            (g) to the extent not covered by Clauses (a) - (f) above, all
proceeds of any and all of the foregoing Pledged Collateral. For purposes of
this Agreement, the term "proceeds" includes whatever is receivable or received
when Pledged Collateral or proceeds are sold, exchanged, collected or otherwise
disposed of, whether such disposition is voluntary or involuntary, and includes,
without limitation, proceeds of any indemnity or guaranty payable to Pledgor or
Secured Party from time to time with respect to any of the Pledged Collateral.

            SECTION 2. Security for Obligations. This Agreement secures, and the
Pledged Collateral is collateral security for, the prompt payment or performance
in full when due, whether at stated maturity, by required prepayment,
declaration, acceleration, demand or otherwise (including the payment of amounts
that would become due but for the operation of the automatic stay under Section
362(a) of the Bankruptcy Code, 11 U.S.C. ss.362(a)), of all obligations and
liabilities of every nature of Pledgor now or hereafter existing under or
arising out of or in connection with the Facilities Agreement and any other
Finance Document (and all extensions or renewals thereof), whether for
principal, interest (including without limitation interest that, but for the
filing of a petition in bankruptcy with respect to Pledgor or any other Obligor,
would accrue on such obligations), fees, expenses, indemnities or otherwise,
whether voluntary or involuntary, direct or indirect, absolute or contingent,
liquidated or unliquidated, whether or not jointly owed with others, and whether
or not from time to time decreased or extinguished and later increased, created
or incurred, and all or any portion of such obligations or liabilities that are
paid, to the extent all or any part of such payment is avoided or recovered
directly or indirectly from Secured Party or any Lender as a preference,
fraudulent transfer or otherwise (all such obligations and liabilities being the
"Underlying Debt"), and all obligations of every nature of Pledgor now or
hereafter existing under this Agreement (all such obligations of Pledgor,
together with the Underlying Debt, being the "Secured Obligations").


                                        3
<PAGE>   4

            SECTION 3. Delivery of Pledged Collateral. All certificates or
instruments representing or evidencing the Pledged Collateral shall be delivered
to and held by or on behalf of Secured Party pursuant hereto and shall be in
suitable form for transfer by delivery or, as applicable, shall be accompanied
by Pledgor's endorsement, where necessary, or duly executed instruments of
transfer or assignment in blank, all in form and substance reasonably
satisfactory to Secured Party. During the occurrence and continuation of an
Event of Default, Secured Party shall have the right, at any time in its
discretion, to transfer to or to register in the name of Secured Party or any of
its nominees any or all of the Pledged Collateral, subject only to the revocable
rights specified in Section 7(a). Secured Party shall notify the Pledgor in
writing as soon as practicable following the exercise of such right. In
addition, Secured Party shall have the right at any time to exchange
certificates or instruments representing or evidencing Pledged Collateral for
certificates or instruments of smaller or larger denominations.

            SECTION 4. Representations and Warranties. The representations and
warranties in respect of the Pledgor set forth in Clauses 12.2 - 12.6 in the
Facilities Ageement are incorporated herein by reference. In addition, Pledgor
represents and warrants as follows:

            (a) Due Authorization, etc. of Pledged Collateral. All of the
Pledged Shares have been duly authorized and validly issued and are fully paid
and non-assessable. The instrument(s) evidencing the Pledged Debt has been duly
authorized authenticated or issued, and delivered and is the legal valid and
binding obligation of the issuer thereof, and the issuer thereof is not in
default thereunder.

            (b) Description of Pledged Shares. The Pledged Shares constitute 100
percent of the issued and outstanding shares of stock of each of the direct
subsidiaries of Pledgor, and there are no outstanding warrants, options or other
rights to purchase, or other agreements outstanding with respect to, or property
that is now or hereafter convertible into, or that requires the issuance or sale
of, any Pledged Shares. The Pledged Debt constitutes all of the issued and
outstanding intercompany indebtedness owing to Pledgor evidenced by a promissory
note issued by any direct or indirect subsidiary of Pledgor.

            (c) Ownership of Pledged Collateral. Pledgor is the legal, record
and beneficial owner of the Pledged Collateral free and clear of any Security
Interest except for the security interest created by this Agreement.

            (d) Governmental Authorizations. No authorization, approval or other
action by, and no notice to or filing with, any governmental authority or
regulatory body is required for either (i) the pledge by Pledgor of the Pledged
Collateral pursuant to this Agreement and the grant by Pledgor of the security
interest granted hereby, (ii) the execution, delivery or performance of this
Agreement by Pledgor, or (iii) the exercise by Secured Party of the voting or
other rights, or the remedies in respect of the Pledged Collateral, provided for
in this Agreement (except as may be required in connection with a disposition of
Pledged Collateral by laws 


                                        4
<PAGE>   5

affecting the offering and sale of securities generally), the failure to so
obtain or undertake would be likely to result in a Material Adverse Effect.

            (e) Perfection. The pledge of the Pledged Collateral pursuant to
this Agreement creates a valid and perfected first priority security interest in
the Pledged Collateral, securing the payment of the Secured Obligations.

            (f) Margin Regulations. The pledge of the Pledged Collateral
pursuant to this Agreement does not violate Regulation G, T, U or X of the Board
of Governors of the Federal Reserve System.

            (g) Other Information. All material written information heretofore,
herein or hereafter supplied to Secured Party by or on behalf of Pledgor with
respect to the Pledged Collateral is accurate and complete in all respects.

            SECTION 5. Transfers and Other Security Interests; Additional
Pledged Collateral Covenants; etc. Pledgor shall:

            (a) not, (i) sell, assign (by operation of law or otherwise) or
otherwise dispose of, or grant any option with respect to, any of the Pledged
Collateral, (ii) create or suffer to exist any Security Interest upon or with
respect to any of the Pledged Collateral, except for the Security Interest under
this Agreement, or (iii) permit any issuer of Pledged Shares to merge or
consolidate unless all the outstanding capital stock of the surviving or
resulting corporation is, upon such merger or consolidation, pledged hereunder
and no cash, securities or other property is distributed in respect of the
outstanding shares of any other constituent corporation;

            (b) (i) cause each issuer of Pledged Shares not to issue any stock
or other securities in addition to or in substitution for the Pledged Shares
issued by such issuer, except to Pledgor, (ii) pledge hereunder, immediately
upon its acquisition (directly or indirectly) thereof, any and all additional
shares of stock or other securities of each issuer of Pledged Shares, and (iii)
pledge hereunder, immediately upon its acquisition (directly or indirectly)
thereof, any and all shares of stock of any person that, after the date of this
Agreement, becomes, as a result of any occurrence, a direct subsidiary of
Pledgor;

            (c) (i) pledge hereunder, immediately upon their issuance, any and
all instruments or other evidences of additional indebtedness from time to time
owed to Pledgor by any obligor on the Pledged Debt, and (ii) pledge hereunder,
immediately upon their issuance, any and all instruments or other evidences of
indebtedness from time to time owed to Pledgor by any person that after the date
of this Agreement becomes, as a result of any occurrence, a direct or indirect
subsidiary of Pledgor;

            (d) promptly notify Secured Party of any event of which Pledgor
becomes aware causing material loss or depreciation in the value of the Pledged
Collateral;



                                       5
<PAGE>   6

            (e) promptly deliver to Secured Party all written notices received
by it with respect to the Pledged Collateral; and

            (f) pay promptly when due all taxes, assessments and governmental
charges or levies imposed upon, and all claims against, the Pledged Collateral,
except to the extent the validity thereof is being contested in good faith;
provided that Pledgor shall in any event pay such taxes, assessments, charges,
levies or claims not later than five days prior to the date of any proposed sale
under any judgement, writ or warrant of attachment entered or filed against
Pledgor or any of the Pledged Collateral as a result of the failure to make such
payment.

            SECTION 6. Further Assurances; Pledge Amendments.

            (a) Pledgor agrees that from time to time, at the expense of
Pledgor, Pledgor will promptly execute and deliver all further instruments and
documents, and take all further action, that may be reasonably necessary or
desirable, or that Secured Party may reasonably request, in order to perfect and
protect any security interest granted or purported to be granted hereby or to
enable Secured Party to exercise and enforce its rights and remedies hereunder
with respect to any and all Pledged Collateral. Without limiting the generality
of the foregoing, Pledgor will: (i) if applicable, execute and file such
financing or continuation statements, or amendments thereto, and such other
instruments or notices, as may be necessary or desirable, or as Secured Party
may reasonably request, in order to perfect and preserve the Security Interests
granted or purported to be granted hereby and (ii) at Secured Party's request,
appear in and defend any action or proceeding that may affect Pledgor's title to
or Secured Party's Security Interest in all or any part of the Pledged
Collateral.

            (b) Pledgor further agrees that it will, upon obtaining any
additional shares of stock or other securities required to be pledged hereunder
as provided in Section 5(b) and/or Section 5(c), promptly (and in any event
within twenty Business Days) deliver to Secured Party a Pledge Amendment, duly
executed by Pledgor, in substantially the form of Schedule II annexed hereto (a
"Pledge Amendment"), in respect of the additional Pledged Shares and/or Pledged
Debt to be pledged pursuant to this Agreement. Pledgor hereby authorizes Secured
Party to attach each Pledge Amendment to this Agreement and agrees that all
Pledged Shares and/or Pledged Debt listed on any Pledge Amendment delivered to
Secured Party shall for all purposes hereunder be considered Pledged Collateral;
provided that the failure of Pledgor to execute a Pledge Amendment with respect
to any additional Pledged Shares and/or Pledged Debt pledged pursuant to this
Agreement shall not impair the Security Interest of Secured Party therein or
otherwise adversely affect the rights and remedies of Secured Party hereunder
with respect thereto.


                                       6
<PAGE>   7

            SECTION 7. Voting Rights and Dividends in respect of Pledged Shares;
Etc.

            (a) So long as no Event of Default shall have occurred and be
continuing:

                  (i) Pledgor shall be entitled to exercise any and all voting
      and other consensual rights pertaining to the Pledged Collateral or any
      part thereof for any purpose not inconsistent with the terms of this
      Agreement or the Facilities Agreement; provided, however, that Pledgor
      shall not exercise or refrain from exercising any such right if Secured
      Party shall have notified Pledgor that, in Secured Party's judgment, such
      action would have a material adverse effect on the value of the Pledged
      Collateral or any part thereof; and provided, further, that Pledgor shall
      give Secured Party at least five Business Days' prior written notice of
      the manner in which it intends to exercise, or the reasons for refraining
      from exercising, any such right. It is understood, however, that neither
      (A) the voting by Pledgor of any Pledged Shares for, or Pledgor's consent
      to, the election of directors at a regularly scheduled annual or other
      meeting of stockholders or with respect to incidental matters at any such
      meeting, nor (B) Pledgor's consent to or approval of any action otherwise
      permitted under this Agreement and the Facilities Agreement shall be
      deemed inconsistent with the terms of this Agreement or the Facilities
      Agreement within the meaning of this Section 7(a)(i), and no notice of any
      such voting or consent need be given to Secured Party;

                  (ii) Pledgor shall be entitled to receive and retain, and to
      utilize free and clear of the Security Interest under this Agreement, any
      and all dividends and interest paid in respect of the Pledged Collateral;
      provided, however, that any and all

                        A. dividends and interest paid or payable other than in
      cash in respect of, and instruments and other property received,
      receivable or otherwise distributed in respect of, or in exchange for, any
      Pledged Collateral,

                        B. dividends and other distributions paid or payable in
      cash in respect of any Pledged Collateral in connection with a partial or
      total liquidation or dissolution or in connection with a reduction of
      capital, capital surplus or paid-in-surplus, and

                        C. cash paid, payable or otherwise distributed in
      respect of principal or in redemption of or in exchange for any Pledged
      Collateral,

      shall be, and shall forthwith be delivered to Secured Party to hold as,
      Pledged Collateral and shall, if received by Pledgor, be received in trust
      for the benefit of Secured Party, be segregated from the other property or
      funds of Pledgor and 


                                       7
<PAGE>   8

      be forthwith delivered to Secured Party as Pledged Collateral in the same
      form as so received (with all necessary endorsements); and

                  (iii) Secured Party shall promptly execute and deliver (or
      cause to be executed and delivered) to Pledgor all such proxies, dividend
      payment orders and other instruments as Pledgor may from time to time
      reasonably request for the purpose of enabling Pledgor to exercise the
      voting and other consensual rights which it is entitled to exercise
      pursuant to paragraph (i) above and to receive the dividends, principal or
      interest payments which it is authorized to receive and retain pursuant to
      paragraph (ii) above.

            (b) Upon the occurrence and during the continuation of an Event of
Default:

                  (i) upon written notice from Secured Party to Pledgor, all
      rights of Pledgor to exercise the voting and other consensual rights which
      it would otherwise be entitled to exercise pursuant to Section 7(a)(i)
      shall cease, and all such rights shall thereupon become vested in Secured
      Party who shall thereupon have the sole right to exercise such voting and
      other consensual rights;

                  (ii) all rights of Pledgor to receive the dividends and
      interest payments which it would otherwise be authorized to receive and
      retain pursuant to Section 7(a)(ii) shall cease, and all such rights shall
      thereupon become vested in Secured Party who shall thereupon have the sole
      right to receive and hold as Pledged Collateral such dividends and
      interest payments; and

                  (iii) all dividends, principal and interest payments which are
      received by Pledgor contrary to the provisions of paragraph (ii) of this
      Section 7(b) shall be received in trust for the benefit of Secured Party,
      shall be segregated from other funds of Pledgor and shall forthwith be
      paid over to Secured Party as Pledged Collateral in the same form as so
      received (with any necessary indorsements).

            (c) In order to permit Secured Party to exercise the voting and
other consensual rights which it may be entitled to exercise pursuant to Section
7(b)(i) and to receive all dividends and other distributions which it may be
entitled to receive under Section 7(a)(ii) or Section 7(b)(ii), (i) Pledgor
shall promptly execute and deliver (or cause to be executed and delivered) to
Secured Party all such proxies, dividend payment orders and other instruments as
Secured Party may from time to time reasonably request and (ii) without limiting
the effect of the immediately preceding clause (i), Pledgor hereby grants to
Secured Party during the occurrence and continuation of an Event of Default an
irrevocable proxy to vote the Pledged Shares and to exercise all other rights,
powers, privileges and remedies to which a holder of the Pledged Shares would be
entitled (including, without limitation, giving or withholding written consents
of shareholders, calling special meetings of shareholders and voting at such
meetings), which proxy shall be effective, automatically and without the
necessity of any action 


                                       8
<PAGE>   9

(including any transfer of any Pledged Shares on the record books of the issuer
thereof) by any other person (including the issuer of the Pledged Shares or any
officer or agent thereof), upon the occurrence and continuation of an Event of
Default and which proxy shall only terminate upon the payment in full of the
Secured Obligations.

            SECTION 8. Secured Party Appointed Attorney-in-Fact. Pledgor hereby
irrevocably appoints Secured Party as Pledgor's attorney-in-fact, with full
authority in the place and stead of Pledgor and in the name of Pledgor, Secured
Party or otherwise, from time to time in Secured Party's discretion to take any
action and to execute any instrument that Secured Party may deem necessary or
advisable to accomplish the purposes of this Agreement, including without
limitation:

            (a) if applicable, to file one or more financing or continuation
statements, or amendments thereto, relative to all or any part of the Pledge
Collateral without the signature of Pledgor;

            (b) to ask for, demand, collect, sue for, recover, compound, receive
and give acquittance and receipts for moneys due and to become due under or in
respect of any of the Pledged Collateral;

            (c) to receive, endorse and collect any drafts or other instruments
made payable to Pledgor representing any dividend, principal or interest payment
or other distribution in respect of the Pledged Collateral or any part thereof
and to give full discharge for the same;

            (d) to file any claims or take any action or institute any
proceedings that Secured Party may deem necessary or desirable for the
collection of any of the Pledged Collateral or otherwise to enforce the rights
of Secured Party with respect to any of the Pledged Collateral; and

            (e) upon the occurrence and during the continuation of an Event of
Default, generally to sell, transfer, pledge, make any agreement with respect to
or otherwise deal with any of the Pledged Collateral as fully and completely as
though Secured Party were the absolute owner thereof for all purposes, and to
do, at Secured Party's option and Pledgor's expense, at any time or from time to
time, all acts and things that Secured Party deems necessary to protect,
preserve or realize upon the Pledged Collateral and Secured Party's Security
Interest therein in order to effect the intent of this Agreement, all as fully
and effectively as Pledgor might do.

            SECTION 9. Secured Party May Perform. If any Pledgor fails to
perform any agreement contained herein, Secured Party may itself perform, or
cause performance of, such agreement, and the expenses of Secured Party incurred
in connection therewith shall be payable by Pledgor under Section 13(b).

            SECTION 10. Standard of Care. The powers conferred on Secured Party
hereunder are solely to protect its interest in the Pledged Collateral and shall
not impose any duty upon it to exercise any such powers. Except for the exercise
of 


                                       9
<PAGE>   10

reasonable care in the custody of any Pledged Collateral in its possession and
the accounting for moneys actually received by it hereunder, Secured Party shall
have no duty as to any Pledged Collateral, it being understood that Secured
Party shall have no responsibility for (a) ascertaining or taking action with
respect to calls, conversions, exchanges, maturities, tenders or other matters
relating to any Pledged Collateral, whether or not Secured Party has or is
deemed to have knowledge of such matters, (b) taking any necessary steps (other
than steps taken in accordance with the standard of care set forth above to
maintain possession of the Pledged Collateral) to preserve rights against any
parties with respect to any Pledged Collateral, (c) taking any necessary steps
to collect or realize upon the Secured Obligations or any guarantee therefor, or
any part thereof, or any of the Pledged Collateral, or (d) initiating any action
to protect the Pledged Collateral against the possibility of a decline in market
value. Secured Party shall be deemed to have exercised reasonable care in the
custody and preservation of Pledged Collateral in its possession if such Pledged
Collateral is accorded treatment substantially equal to that which Secured Party
accords its own property consisting of negotiable securities.

            SECTION 11. Remedies.

            (a) If any Event of Default shall have occurred and be continuing
and, in any case other than the failure to pay amounts due upon final maturity,
the Agent has served notice on the Borrower pursuant to Clause 14.3
(Cancellation and Repayment) under the Facilities Agreement, Secured Party may
exercise in respect of the Pledged Collateral, in addition to all other rights
and remedies provided for herein or otherwise available to it, all the rights
and remedies of a secured party on default under the Uniform Commercial Code as
in effect in any relevant jurisdiction (the "Code") (whether or not the Code
applies to the affected Pledged Collateral), and Secured Party may also in its
sole discretion, without notice except as specified below, sell the Pledged
Collateral or any part thereof in one or more parcels at public or private sale,
at any exchange or broker's board or at any of Secured Party's offices or
elsewhere, for cash, on credit or for future delivery, at such time or times and
at such price or prices and upon such other terms as Secured Party may deem
commercially reasonable, irrespective of the impact of any such sales on the
market price of the Pledged Collateral. Secured Party or any Lender may be the
purchaser of any or all of the Pledged Collateral at any such sale and Secured
Party, as agent for and representative of Lenders (but not any Lender or Lenders
in its or their respective individual capacities unless Majority Lenders shall
otherwise agree in writing), shall be entitled, for the purpose of bidding and
making settlement or payment of the purchase price for all or any portion of the
Pledged Collateral sold at any such public sale, to use and apply any of the
Secured Obligations as a credit on account of the purchase price for any Pledged
Collateral payable by Secured Party at such sale. Each purchaser at any such
sale shall hold the property sold absolutely free from any claim or right on the
part of Pledgor, and Pledgor hereby waives (to the extent permitted by
applicable law) all rights of redemption, stay and/or appraisal which it now has
or may at any time in the future have under any rule of law or statute now
existing or hereafter enacted. Pledgor agrees that, to the extent notice of sale
shall be required by law, at least ten days' notice to Pledgor of the time and
place of any public sale or the time after which 


                                       10
<PAGE>   11

any private sale is to be made shall constitute reasonable notification. Secured
Party shall not be obligated to make any sale of Pledged Collateral regardless
of notice of sale having been given. Secured Party may adjourn any public or
private sale from time to time by announcement at the time and place fixed
therefor, and such sale may, without further notice, be made at the time and
place to which it was so adjourned. Pledgor hereby waives any claims against
Secured Party arising by reason of the fact that the price at which any Pledged
Collateral may have been sold at such a private sale was less than the price
which might have been obtained at a public sale, even if Secured Party accepts
the first offer received and does not offer such Pledged Collateral to more than
one offeree. If the proceeds of any sale or other disposition of the Pledged
Collateral are insufficient to pay all the Secured Obligations, Pledgor shall be
liable for the deficiency and the fees of any attorneys employed by Secured
Party to collect such deficiency.

            (b) Pledgor recognizes that, by reason of certain prohibitions
contained in the Securities Act of 1933, as from time to time amended (the
"Securities Act"), and applicable state securities laws, Secured Party may be
compelled, with respect to any sale of all or any part of the Pledged Collateral
conducted without prior registration or qualification of such Pledged Collateral
under the Securities Act and/or such state securities laws, to limit purchasers
to those who will agree, among other things, to acquire the Pledged Collateral
for their own account, for investment and not with a view to the distribution or
resale thereof. Pledgor acknowledges that any such private sales may be at
prices and on terms less favorable than those obtainable through a public sale
without such restrictions (including, without limitation, a public offering made
pursuant to a registration statement under the Securities Act) and,
notwithstanding such circumstances, Pledgor agrees that any such private sale
shall be deemed to have been made in a commercially reasonable manner and that
Secured Party shall have no obligation to engage in public sales and no
obligation to delay the sale of any Pledged Collateral for the period of time
necessary to permit the issuer thereof to register it for a form of public sale
requiring registration under the Securities Act or under applicable state
securities laws, even if such issuer would, or should, agree to so register it.

            (c) If Secured Party determines to exercise its right to sell any or
all of the Pledged Collateral, upon written request, Pledgor shall and shall
cause each issuer of any Pledged Debt to be sold hereunder from time to time to
furnish to Secured Party all such information as Secured Party may request in
order to determine the number of instruments included in the Pledged Collateral
which may be sold by Secured Party in exempt transactions under the Securities
Act and the rules and regulations of the Securities and Exchange Commission
thereunder, as the same are from time to time in effect.

            SECTION 12. Application of Proceeds. Except as expressly provided
elsewhere in this Agreement, all proceeds received by Secured Party in respect
of any sale of, collection from, or other realization upon all or any part of
the Pledged Collateral may, in the discretion of Secured Party, be held by
Secured Party as Pledged Collateral for, and/or then, or at any time thereafter,
applied in full or in part by Secured Party against, the Secured Obligations in
the following order of priority:


                                       11
<PAGE>   12

            FIRST: To the payment of all costs and expenses of such sale,
      collection or other realization, including reasonable compensation to
      Secured Party and its agents and counsel, and all other expenses,
      liabilities and advances made or incurred by Secured Party in connection
      therewith, and all amounts for which Secured Party is entitled to
      indemnification hereunder and all advances made by Secured Party hereunder
      for the account of Pledgor, and to the payment of all costs and expenses
      paid or incurred by Secured Party in connection with the exercise of any
      right or remedy hereunder, all in accordance with Section 13;

            SECOND: To the payment of all other Secured Obligations in the order
      described in Clause 18 of the Facilities Agreement; and

            THIRD: To the payment to or upon the order of Pledgor, or to
      whosoever may be lawfully entitled to receive the same or as a court of
      competent jurisdiction may direct, of any surplus then remaining from such
      proceeds.

            SECTION 13. Indemnity and Expenses.

            (a) Pledgor agrees to indemnify Secured Party and each Lender from
and against any and all claims, losses and liabilities in any way relating to,
growing out of or resulting from this Agreement and the transactions
contemplated hereby (including, without limitation, enforcement of this
Agreement), except to the extent such claims, losses or liabilities result from
Secured Party's or such Lender's gross negligence or willful misconduct as
finally determined by a court of competent jurisdiction.

            (b) Pledgor shall pay to Secured Party upon demand the amount of any
and all costs and expenses, including the reasonable fees and expenses of its
counsel and of any experts and agents, that Secured Party incurs in connection
with (i) the administration of this Agreement, (ii) the custody or preservation
of, or the sale of, collection from, or other realization upon, any of the
Pledged Collateral, (iii) the exercise or enforcement of any of the rights of
Secured Party hereunder, or (iv) the failure by Pledgor to perform or observe
any of the provisions hereof.

            SECTION 14. Continuing Security Interest; Transfer of Loans. This
Agreement shall create a continuing security interest in the Pledged Collateral
and shall (a) remain in full force and effect until the payment in full of all
Secured Obligations and the cancellation or termination of the Commitment, (b)
be binding upon Pledgor, its successors and assigns, and (c) inure, together
with the rights and remedies of Secured Party hereunder, to the benefit of
Secured Party and its succes sors, transferees and assigns. Without limiting the
generality of the foregoing clause (c), but subject to the provisions of Clause
25 of the Facilities Agreement, any Lender may assign or otherwise transfer any
Loans held by it to any other person, and such other person shall thereupon
become vested with all the benefits in respect thereof granted to Lenders herein
or otherwise. Upon the payment in full of all Secured Obligations and the
cancellation or termination of the Commitment and the security interest granted


                                       12
<PAGE>   13

hereby shall terminate and all rights to the Pledged Collateral shall revert to
Pledgor. Upon any such termination Secured Party will, at Pledgor's expense,
execute and deliver to Pledgor such documents as Pledgor shall reasonably
request to evidence such termination and Pledgor shall be entitled to the
return, upon its request and at its expense, against receipt and without
recourse to Secured Party, of such of the Pledged Collateral as shall not have
been sold or otherwise applied pursuant to the terms hereof.

            SECTION 15. Amendments; Etc. No amendment, modification, termination
or waiver of any provision of this Agreement, and no consent to any departure by
Pledgor therefrom, shall in any event be effective unless the same shall be in
writing and signed by Secured Party and, in the case of any such amendment or
modification, by Pledgor. Any such waiver or consent shall be effective only in
the specific instance and for the specific purpose for which it was given.

            SECTION 16. Notices. Any notice or other communication herein
required or permitted to be given shall be in writing and may be personally
served, telexed or sent by telefacsimile or United States mail or courier
service and shall be deemed to have been given when delivered in person or by
courier service, upon receipt of telefacsimile or telex, or three Business Days
after depositing it in the United States mail with postage prepaid and properly
addressed. For the purposes hereof, the address of each party hereto shall be as
set forth under such party's name on the signature pages hereof or, as to either
party, such other address as shall be designated by such party in a written
notice delivered to the other party hereto.

            SECTION 17. Failure or Indulgence Not Waiver; Remedies Cumulative.
No failure or delay on the part of Secured Party in the exercise of any power,
right or privilege hereunder shall impair such power, right or privilege or be
construed to be a waiver of any default or acquiescence therein, nor shall any
single or partial exercise of any such power, right or privilege preclude any
other or further exercise thereof or of any other power, right or privilege. All
rights and remedies existing under this Agreement are cumulative to, and not
exclusive of, any rights or remedies otherwise available.

            SECTION 18. Severability. In case any provision in or obligation
under this Agreement shall be invalid, illegal or unenforceable in any
jurisdiction, the validity, legality and enforceability of the remaining
provisions or obligations, or of such provision or obligation in any other
jurisdiction, shall not in any way be affected or impaired thereby.

            SECTION 19. Headings. Section and subsection headings in this
Agreement are included herein for convenience of reference only and shall not
constitute a part of this Agreement for any other purpose or be given any
substantive effect.

            SECTION 20. Governing Law; Terms. THIS AGREEMENT AND THE RIGHTS AND
OBLIGATIONS OF THE PARTIES HEREUNDER SHALL 


                                       13
<PAGE>   14

BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE
INTERNAL LAWS OF THE STATE OF NEW YORK (INCLUDING WITHOUT LIMITATION SECTION
5-1401 OF THE GENERAL OBLIGATIONS LAW OF THE STATE OF NEW YORK), WITHOUT REGARD
TO CONFLICTS OF LAWS PRINCIPLES, EXCEPT TO THE EXTENT THAT THE CODE PROVIDES
THAT THE VALIDITY OR PERFECTION OF THE SECURITY INTEREST HEREUNDER, OR REMEDIES
HEREUNDER, IN RESPECT OF ANY PARTICULAR PLEDGED COLLATERAL ARE GOVERNED BY THE
LAWS OF A JURISDICTION OTHER THAN THE STATE OF NEW YORK. Unless otherwise
defined herein or in the Facilities Agreement, terms used in Articles 8 and 9 of
the Uniform Commercial Code in the State of New York are used herein as therein
defined.

            SECTION 21. Consent to Jurisdiction and Service of Process. ALL
JUDICIAL PROCEEDINGS BROUGHT AGAINST PLEDGOR ARISING OUT OF OR RELATING TO THIS
AGREEMENT MAY BE BROUGHT IN ANY STATE OR FEDERAL COURT OF COMPETENT JURISDICTION
IN THE STATE OF NEW YORK, AND BY EXECUTION AND DELIVERY OF THIS AGREEMENT
PLEDGOR ACCEPTS FOR ITSELF AND IN CONNECTION WITH ITS PROPERTIES, GENERALLY AND
UNCONDITIONALLY, THE NONEXCLUSIVE JURISDICTION OF THE AFORESAID COURTS AND
WAIVES ANY DEFENSE OF FORUM NON CONVENIENS AND IRREVOCABLY AGREES TO BE BOUND BY
ANY JUDGMENT RENDERED THEREBY IN CONNECTION WITH THIS AGREEMENT. Pledgor hereby
agrees that service of all process in any such proceeding in any such court may
be made by registered or certified mail, return receipt requested, to Pledgor at
its address provided in Section 16, such service being hereby acknowledged by
Pledgor to be sufficient for personal jurisdiction in any action against Pledgor
in any such court and to be otherwise effective and binding service in every
respect. Nothing herein shall affect the right to serve process in any other
manner permitted by law or shall limit the right of Secured Party to bring
proceedings against Pledgor in the courts of any other jurisdiction.

            SECTION 22. Waiver of Jury Trial. PLEDGOR AND SECURED PARTY HEREBY
AGREE TO WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF
ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT. The scope of this waiver is
intended to be all-encompassing of any and all disputes that may be filed in any
court and that relate to the subject matter of this transaction, including
without limitation contract claims, tort claims, breach of duty claims, and all
other common law and statutory claims. Pledgor and Secured Party each
acknowledge that this waiver is a material inducement for Pledgor and Secured
Party to enter into a business relationship, that Pledgor and Secured Party have
already relied on this waiver in entering into this Agreement and that each will
continue to rely on this waiver in their related future dealings. Pledgor and
Secured Party further warrant and represent that each has reviewed this waiver
with its legal counsel, and that each knowingly and voluntarily waives its jury
trial rights following consultation with legal counsel. THIS WAIVER IS
IRREVOCABLE, MEANING THAT IT MAY NOT BE MODIFIED EITHER ORALLY OR IN 


                                       14
<PAGE>   15

WRITING, AND THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS,
SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT. In the event of litigation, this
Agree ment may be filed as a written consent to a trial by the court.

            SECTION 23. Counterparts. This Agreement may be executed in one or
more counterparts and by different parties hereto in separate counterparts, each
of which when so executed and delivered shall be deemed an original, but all
such counterparts together shall constitute but one and the same instrument;
signature pages may be detached from multiple separate counterparts and attached
to a single counterpart so that all signature pages are physically attached to
the same document.

                  [Remainder of page intentionally left blank]



                                       15
<PAGE>   16

            IN WITNESS WHEREOF, Pledgor and Secured Party have caused this
Agreement to be duly executed and delivered by their respective duly authorized
representatives as of the date first written above.


                                    CHIREX INC., as Pledgor


                                    By: /s/ Michael A. Griffith
                                       ----------------------------------
                                    Print Name: Michael A. Griffith
                                    Title: Chief Financial Officer


                                    BANKERS TRUST COMPANY, as
                                    Secured Party


                                    By: /s/ Elene A. Harkavy
                                       ----------------------------------
                                    Print Name: Elene A. Harkavy
                                    Title: Vice President


Acknowledged and Agreed to by
CHIREX (HOLDINGS) LIMITED


By: /s/ Michael A. Griffith
   ---------------------------
Print Name: Michael A. Griffith
Title: Chief Financial Officer

Borrower, by countersigning this Agreement and as a contractual undertaking
acknowledges the terms of this Agreement and irrevocably accepts to pay any
amounts owed by it in respect of the Secured Obligations to the person(s)
entitled to receive such payments in accordance with the terms of this
Agreement, without right of set-off counterclaim or otherwise, notwithstanding
that the validity, scope, methods of enforcement or any other matters relating
to the Pledged Collateral or to this Agreement may in certain jurisdictions, in
particular vis-a-vis third parties, be subject to mandatory provisions of local
laws other than those of the State of New York.


                                       S-1
<PAGE>   17

                                   SCHEDULE I

Attached to and forming a part of the Pledge Agreement dated as of
_____________, 1997 between ChiRex Inc., as Pledgor, and Bankers Trust Company,
as Secured Party.


                                     Part A

                       Class of      Stock Certi-      Par         Number of
Stock Issuer            Stock        ficate Nos.       Value         Shares
- ------------            -----        -----------       -----         ------

ChiRex (Holdings) Limited

ChiRex America, Inc.



                                     Part B

Debt Issuer                        Amount of Indebtedness
- -----------                        ----------------------

ChiRex (Holdings) Limited                GBP 25,192,000


                                     SI - 1
<PAGE>   18

                                   SCHEDULE II

                                PLEDGE AMENDMENT


This Pledge Amendment, dated _________________, is delivered pursuant to Section
6(b) of the Pledge Agreement referred to below. The undersigned hereby agrees
that this Pledge Amendment may be attached to the Pledge Agreement dated
_________ 1997, between the undersigned and Bankers Trust Company, as Secured
Party (the "Pledge Agreement," capitalized terms defined therein being used
herein as therein defined), and that the [Pledged Shares] [Pledged Debt] listed
on this Pledge Amendment shall be deemed to be part of the [Pledged Shares]
[Pledged Debt] and shall become part of the Pledged Collateral and shall secure
all Secured Obligations.


                                   ChiRex Inc., as Pledgor



                                   By: _________________________________
                                   Print Name:
                                   Title:




                       Class of      Stock Certi-      Par         Number of
Stock Issuer            Stock        ficate Nos.       Value         Shares
- ------------            -----        -----------       -----         ------





Debt Issuer                          Amount of Indebtedness
- -----------                          ----------------------


                                     SII - 1


<PAGE>   1

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission. 

                                                              September 23, 1997


                         GLAXO OPERATIONS UK LIMITED (1)

                                       and

                           CHIREX (ANNAN) LIMITED (2)

                                       and

                          CHIREX (HOLDINGS) LIMITED (3)

                                ----------------

                                SUPPLY AGREEMENT

                                ----------------
<PAGE>   2

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                TABLE OF CONTENTS

CLAUSE                                                                   PAGE NO

1. DEFINITIONS AND INTERPRETATION................................... 1

2. SUPPLY OF PRODUCTS............................................... 4

3. PRICE/PAYMENT.................................................... 7

4. SUPPLY OF RAW MATERIALS.......................................... 9

5. FORECASTS; ORDERS; DELIVERY..................................... 10

6. TITLE/RISK OF LOSS.............................................. 10

7. PREMISES/PLANT.................................................. 10

8. COVENANTS AS TO QUALITY AND QUANTITY............................ 11

9. SAMPLES; INSPECTIONS............................................ 12

10. TECHNICAL ASSISTANCE........................................... 13

11. HAZARDS........................................................ 13

12. INTELLECTUAL PROPERTY; IMPROVEMENTS............................ 13

13. CONFIDENTIALITY................................................ 15

14. CONSENTS....................................................... 16

15. ASSIGNMENT..................................................... 16

16. DURATION....................................................... 17

17. DENIAL OF RIGHTS............................................... 20
<PAGE>   3

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


18. PRODUCT COMPLAINTS; ADVERSE EVENT REPORTS...................... 20

19. INDEMNITIES.................................................... 20

20. INSURANCE...................................................... 21

21. FORCE MAJEURE.................................................. 22

22. NOTICES........................................................ 22

23. DISPUTE RESOLUTION............................................. 23

24. PUBLICITY...................................................... 23

25. CONTRACT ADMINISTRATION........................................ 23

26. LIABILITY...................................................... 24

27. WAIVER......................................................... 24

28. CONSENT TO JURISDICTION........................................ 24

29. ENTIRETY....................................................... 24

30. LAW............................................................ 24

31. SUCCESSORS AND ASSIGNS......................................... 24

32. PARTIES........................................................ 24



SCHEDULE 1 - THE PRODUCTS.......................................... 26

SCHEDULE 2 - KEY MATERIALS......................................... 27

SCHEDULE 3 - NOTIONAL CAPACITY REQUIREMENTS........................ 28

SCHEDULE 4 - FORMULA FOR PROFIT SHARE.............................. 30
<PAGE>   4

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                SUPPLY AGREEMENT

THIS AGREEMENT is dated                                       September 23, 1997
BETWEEN:

(1)   GLAXO OPERATIONS UK LIMITED registered number 711851 whose registered
      office is at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex
      UB6 0NN ('Glaxo Operations')

(2)   CHIREX (ANNAN) LIMITED registered number 3417229 whose registered office
      is at Dudley, Cramlington, Northumberland NE23 7QG ("Chirex Annan")

(3)   CHIREX (HOLDINGS) LIMITED whose registered office is at Dudley,
      Cramlington, Northumberland NE23 7QG ("Chirex Holdings")

WHEREAS:

The Parties have agreed that Chirex Annan or another company within the Chirex
Group would manufacture and supply and Glaxo Operations would purchase certain
active ingredients and intermediates for use in pharmaceutical products under
the terms of this agreement.

NOW IT IS HEREBY AGREED AS FOLLOWS:

1.    DEFINITIONS AND INTERPRETATION

      1.1.  In this agreement the following expressions shall have the following
            meanings unless the context otherwise requires:

            "Added Value" means, in relation to a Product the price payable (or
            which would have been payable for the Product by Glaxo Operations
            had Glaxo Operations ordered it) under the terms of this agreement
            less (a) Chirex Annan's cost of raw materials employed (or which
            would have been employed had Glaxo Operations ordered the Product)
            in Manufacturing that Product (b) any variable costs directly
            incurred in respect of the Manufacture of that Product], and the
            packaging costs and the cost of disposal of effluent in respect of
            the Manufacture of that Product;

            "Approved Supplier" means a person designated in the Manufacturing
            Instructions which has been approved by Glaxo Operations in writing
            for the supply of Raw Materials;


                                       1
<PAGE>   5

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Chirex Group" means Chirex (Holdings) Limited , any parent company
            of Chirex Holdings Limited and any company which, in relation to
            Chirex (Holdings) Limited and/or any parent company of Chirex
            (Holdings) Limited is a subsidiary undertaking from time to time;

            "Chirex Holdings" means Chirex (Holdings) Limited, whose registered
            office is at Dudley, Cramlington, Northumberland NE23 7QG;

            "Contract Year" means, in the case of the first Contract Year, the
            period from the date of this agreement to 31 December 1997 and in
            the case of subsequent Contract Years the respective periods
            commencing on 1 January and ending on 31 December of the same year;

            "Current Good Manufacturing Practices" or "CGMP's" means all
            applicable standards relating to manufacturing practices for fine
            chemicals, intermediates, or bulk pharmaceutical products (i)
            promulgated by any Governmental Body having jurisdiction over the
            manufacture of the Products in the form of laws or regulations, (ii)
            promulgated by any Governmental Body having jurisdiction over the
            Manufacture of the Products, in the form of guidance documents
            (including but not limited to advisory opinions, compliance policy
            guides and guidelines) which guidance documents have been
            implemented within the pharmaceutical manufacturing industry for
            such products in each case as in effect at the date of this
            agreement and as amended, promulgated or accepted from time to time
            during the term of this agreement;

            "Facility" means the manufacturing facility of Chirex (Annan)
            Limited located at Annan and/or the manufacturing facility of Chirex
            (Dudley) Limited located at Dudley;

            "Firm Commitments" means in respect of any Product the quantities of
            such Product so identified in Schedule 1;


                                       2
<PAGE>   6

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Force Majeure" means any decree, restraint, order, rule, regulation
            or other interference by any government or local authority, war,
            strike, lockout, trade dispute, riot, epidemic disease, act of God,
            inevitable accident, breakdown of plant or machinery, fire, flood or
            any other circumstances whatsoever whether similar to the above
            causes or not over which Glaxo Operations or Chirex Annan, as the
            case may be, shall have no control;

            "Governmental Body" means any government department or agency,
            regulatory authority or any entity with legal authority to exercise
            executive, legislative, judicial, regulatory or administrative
            functions;

            "GW Group" means Glaxo Operations, any parent company of Glaxo
            Operations and any company which, in relation to Glaxo Operations
            and/or any parent company of Glaxo Operations, is a subsidiary
            undertaking from time to time;

            "Intended Quantities" means the quantities of **** and **** so
            identified in Schedule 1;

            "Key Materials" means those Raw Materials to be used in the
            Manufacture of the Products set out in Column 1 of Schedule 2;

            "Manufacture" means all operations in the production and/or
            packaging of Products and 'Manufactured' shall be construed
            accordingly;

            "Manufacturing Instructions" means full descriptions and
            instructions concerning Raw Materials usage, operating conditions,
            process and quality standards to be employed by Chirex Annan in the
            Manufacture of Products, including Product specifications, packaging
            instructions and quality control procedures, details of which have
            been communicated by Glaxo Operations and agreed by Chirex Annan;

            ****


                                       3
<PAGE>   7

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            "Other Materials" means all Raw Materials other than the Key
            Materials;

            "Parties" means the parties in this agreement;

            "Products" means the compounds listed in Column 1 of Schedule 1;

            "Quarter" means a period of three months beginning on 1 January, 1
            April, 1 July, or 1 October respectively;

            "Raw Materials" means all raw and packaging materials used in the
            Manufacture of the Products; and

            "Replacement Products" means the products identified as such in
            Schedule 1 and such other products agreed by the Parties from time
            to time.

      1.2.  The headings in this agreement are for ease of reference only and do
            not form part of this agreement for the purposes of interpretation.

      1.3   References to persons in this agreement shall mean any individual or
            corporation, company, partnership, trust, incorporated or
            unincorporated association, joint venture or other entity of any
            kind.

2.    SUPPLY OF PRODUCTS

      2.1   Chirex Annan hereby agrees to Manufacture and sell to Glaxo
            Operations in each Contract Year the volumes of Products set out in
            Schedule 1 during the term of this agreement at the prices set forth
            in Schedule 1, or as adjusted in accordance with the terms of this
            agreement, and Glaxo Operations agrees to purchase such Products at
            such prices. Schedule 1 sets out Firm Commitments and Intended
            Quantities. It is acknowledged by the Parties that Glaxo Operations
            is unable, at the date of this agreement, to confirm that it will
            purchase the volumes of **** and **** designated as Intended
            Quantities in Schedule 1, due to regulatory and market
            uncertainties.


                                       4
<PAGE>   8

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      2.2   While Glaxo Operations is committed to honouring its commitments and
            obligations under clause 2.1, the Parties recognise and agree that
            the purchase of the Intended Quantities of some volumes of **** in
            2000 and thereafter and in all the volumes of **** may be inhibited
            due to regulatory and market uncertainties in relation to these
            Products or the products manufactured from the Products. In the
            event that Glaxo Operations is unable, due to lack of regulatory
            approval and/or marketing uncertainties to purchase the Intended
            Quantities of **** in 2000 and thereafter or of **** at any time
            then the Parties will in good faith negotiate and Glaxo Operations
            shall use its best endeavours to purchase Replacement Products to
            compensate Chirex Annan in full for any such shortfall. The
            principle of such compensation shall be to make up volumes of
            Intended Quantities with volumes of Replacement Products which will
            result in equivalent Added Value to Chirex Annan and/or any other
            company in the Chirex Group. The terms of purchase of such
            Replacement Product shall be the same, mutatis mutandis, as under
            this agreement.

      2.3   The Parties recognise that it may be desirable, particularly at the
            beginning or end of any Contract Year for a Product scheduled to be
            Manufactured and/or purchased in one Contract Year to be
            Manufactured and/or purchased in the following or immediately
            preceding Contract Year. The Party proposing any such rescheduling
            shall give as much advance notice of its proposals as is reasonably
            practicable. Any such rescheduling shall be subject to the agreement
            of the Parties.

      2.4   In respect of the Product ****, the Firm Commitments shall include
            the requirement of **** and its affiliates. If and to the extent
            that quantities of such product are purchased by **** and its
            affiliates direct from Chirex Annan and/or any other company in the
            Chirex Group, such quantities shall be deemed to have been purchased
            by Glaxo Operations for the purpose of fulfilling Glaxo Operations'
            obligations under this clause 2.

      2.5   If Glaxo Operations is unable for any reason (other than due to the
            default of Chirex Annan) to purchase any Firm Commitments of any
            Product Glaxo Operations shall in that event compensate Chirex Annan
            in full in accordance with the terms of this 


                                       5
<PAGE>   9

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            clause but not further or otherwise. Notwithstanding this Chirex
            Annan will use its reasonable endeavours to evaluate in good faith
            the possibility of the Manufacture of other products including the
            Replacement Products or increased volumes of Products for Glaxo
            Operations to purchase on the same terms as this agreement.

            If, in respect of any Contract Year, Glaxo Operations orders less
            Product than the amount set out in Schedule 1 with reference to that
            Contract Year as a Firm Commitment, Glaxo Operations shall, on or
            before 14 January in the immediately following Contract Year, pay to
            Chirex Annan a sum in pounds sterling equal to the Added Value which
            would have been generated had Glaxo Operations submitted orders for
            such quantity of the Product as represents the difference between
            the amount of Product actually ordered by Glaxo Operations in
            respect of the Contract Year in question and the Firm Commitment
            amount which it undertook to order under the terms of clause 2.

      2.6   Without prejudice to Chirex Annan's obligations under clause 2.1 and
            5, Chirex Annan undertakes to have sufficient capacity available at
            the Facilities to Manufacture not less than 10% in excess of orders
            placed by Glaxo Operations under the terms of this agreement in
            accordance with the following procedure:

            2.6.1 Glaxo Operations shall advise its proposed Firm Commitment
                  volumes for the next Contract Year by 30 August of the
                  previous year;

            2.6.2 Chirex Annan will by October of the previous year advise Glaxo
                  Operations of the production schedule for the following
                  Contract Year including (a) timing of available capacity to
                  make up to 10% in excess of the Firm Commitment and (b) any
                  opportunity to Manufacture in excess of 10% more than the Firm
                  Commitment;

            2.6.3 Glaxo Operations will by November of the previous year advise
                  Chirex Annan of its wish to reserve available capacity for in
                  excess of 10% of the Firm Commitment in respect of the
                  following Contract Year. Chirex Annan 


                                       6
<PAGE>   10

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                  shall advise Glaxo Operations whether it is able to reserve
                  any further capacity but shall be under no obligation to do
                  so. If such additional capacity is available the Parties will
                  then negotiate a reservation fee as it is recognised that
                  Chirex Annan will be holding an under utilised capacity for
                  Glaxo Operations. Schedule 3 sets out Chirex Annan's current
                  estimate of the capacity which it expects to be available at
                  the Facilities in respect of the Products in the periods set
                  out.

      2.7   It is acknowledged that it is the intention of Glaxo Operations and
            Chirex Annan to achieve volumes of Products (not Replacement
            Products) in excess of the total number specified in Schedule 1.

      2.8   In the event that Chirex Annan is unable to perform its obligations
            under this agreement in respect of confirmed orders placed by Glaxo
            Operations and accepted by Chirex Annan in accordance with the terms
            of this agreement Firm Commitments quantities specified in Schedule
            1 shall be reduced to the extent of such shortfall, without
            prejudice to any other rights Glaxo Operations may have under this
            agreement. For the avoidance of doubt there shall be no obligation
            on Glaxo Operations to make up any such shortfall in later Contract
            Years.

      2.9   This clause shall apply if Glaxo Operations places a confirmed order
            under this agreement and Glaxo Operations subsequently gives Chirex
            Annan written notice that it is unable to comply with such order. In
            this event any savings of fixed costs of Chirex Annan or other
            member of the Chirex Group which Chirex Annan can make by using the
            capacity which had been reserved for the manufacture of such Product
            and which is actually used in the Manufacture, in the same period,
            of product for a third party, shall be deducted from any payments
            due by Glaxo Operations in respect of such order.

      2.10  The **** of **** to be ordered in accordance with Schedule 1 in
            respect of 1997 will be reduced, if this agreement is entered into
            after 10 October 1997. The reduction will be calculated according to
            a formula being the number of days from 1 October 


                                       7
<PAGE>   11

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            1997 to the date this agreement is entered into divided by 92 days
            and multiplied by ****.

      2.11  Glaxo Operations shall have met its obligations with regard to Firm
            Commitments and Intended Quantities if it purchases products from
            Chirex Annan irrespective of individual product volumes that will
            result in equivalent Added Value to Chirex Annan in respect of any
            Contract Year had the quantities specified in Schedule 1 been
            ordered in that Contract Year.

3.    PRICE/PAYMENT

      3.1   3.1. Glaxo Operations shall pay Chirex Annan in accordance with the
            sums set out in Schedule 1 for all Products purchased under this
            agreement. Chirex Annan shall bear the cost of delivery within the
            United Kingdom. Glaxo Operations shall in addition pay to Chirex
            Annan any delivery costs and any taxes, or import or export duties
            in respect of deliveries outside of the UK.

      3.2   Glaxo Operations shall make payment to Chirex Annan not later than
            30 days from the date of invoice. In respect of **** and **** and in
            respect of such other products as the Parties may agree which are
            Manufactured in a campaign Chirex Annan shall be entitled to invoice
            monthly during the term of such campaign, the volume actually
            available for despatch. Chirex Annan shall invoice Glaxo Operations
            upon notifying Glaxo Operations in writing that the Product has been
            Manufactured and is available for delivery to Glaxo Operations and
            whether or not Glaxo Operations shall have ordered such delivery.

      3.3   The prices payable for the Products shall be adjusted annually
            before the end of the year immediately preceding the Contract Year
            in respect of which such adjusted price is to apply. The adjusted
            price shall reflect any material costs variations (upwards or
            downwards) since the last adjustment (or, in the case of the first
            adjustment since the date of this agreement) in Chirex Annan's unit
            raw materials costs plus direct costs 


                                       8
<PAGE>   12

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            base (including labour and overheads) and usage yields and, in
            respect of the Contract Years 2001, and 2002 shall take into account
            the ****. The adjusted price in respect of the future supply of any
            particular Product shall also reflect any cost savings achieved
            through process improvements (achieved in respect of that Product
            only) provided that any such adjustments shall only be made if the
            Added Value derived from the total volume of Products ordered by
            Glaxo Operations for that Contract Year exceeds the Added Value that
            would have been derived if Glaxo Operations had ordered the
            aggregate volumes of Firm Commitments and Intended Quantities set
            out in Schedule 1.

      3.4   During August of each Contract Year, or at any other time which the
            Parties agree (save for the first Contract Year) in which case the
            relevant month shall be November) in the year immediately preceding
            the year in relation to which such adjusted price is to apply Chirex
            Annan shall deliver to Glaxo Operations a statement showing in
            relation to each Product the variations in costs detailing raw
            material (usage and conversion)and direct costs.

            Within 30 days following delivery of such statement the Parties
            shall discuss the statement and endeavour to agree the amount of the
            variations and the amount by which the price in respect of each
            Product shall be adjusted. Glaxo Operations shall be entitled, as
            part of its review, to require Chirex Annan to provide it with such
            underlying financial information as is relevant in relation to the
            statement produced by Chirex Annan.

            If the Parties agree the amount of the variation within the 30 day
            period (or such longer period as they may agree) they shall agree,
            by exchange of correspondence, the price adjustment to the Product.
            If the Parties fail to so agree, either of them may refer the matter
            for determination in accordance with the terms of clause 23.

      3.5   Any price adjustment agreed or determined under clause 3.4 shall
            have effect as from 1 January in each year (or such other date as
            the parties may agree), regardless of the date of agreement or
            determination.


                                       9
<PAGE>   13

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      3.6   The Parties acknowledge that it is their intention that orders in
            excess of the volumes set out in Schedule 1 both in respect of Firm
            Commitments and Intended Quantities identified in Schedule 1 (not
            Replacement Products) are placed under this agreement. In this event
            any Added Value to which Chirex Annan would be entitled in respect
            of such additional orders shall be applied between the Parties in
            accordance with the terms of Schedule 4. Any applications under this
            clause shall be made at six monthly intervals, or at such other
            times as the Parties may agree. The Parties shall review in November
            of each year the procedure for such allocation which may, at the
            request of Glaxo Operations, be made in respect of the prices to be
            paid for ****. The Parties shall agree when to make such
            applications.

      3.7   All prices are stated exclusive of applicable taxes and VAT and,
            where appropriate, taxes and VAT will be added to all invoices at
            the rate applicable on the tax point date which shall be the date of
            that invoice.

4.          SUPPLY OF RAW MATERIALS

      4.1.  Subject to clauses 4.2 and 4.3 Chirex Annan shall procure at its own
            expense all Raw Materials for the Manufacture of the Products.

      4.2.  Where the Manufacturing Instructions name one or more Approved
            Suppliers for Other Materials, Chirex Annan shall obtain that Other
            Material only from an Approved Supplier thereof.

      4.3   Subject to clause 4.4 in respect of Key Materials Glaxo Operations
            shall select each supplier for the Key Materials and shall have the
            right to designate to Chirex Annan the quantity, consistent with
            contracted volumes, of each Key Material to be purchased from such
            designated supplier. The designated supplier may be Glaxo Operations
            itself or a member of the GW Group. The initial designated suppliers
            for Key Materials are listed in column 2 of Schedule 2.


                                       10
<PAGE>   14

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      4.4   Chirex Annan shall not utilise any Key Materials purchased under
            this agreement for any purposes other than the Manufacture of the
            relevant Products in accordance with the terms of this agreement and
            to the extent that Glaxo Operations is in breach of its obligations
            to order the relevant Product under the terms of this agreement
            Glaxo Operations shall reimburse Chirex for the Key Materials
            therefor.

      4.5   It is acknowledged that Chirex Annan shall be entitled to
            Manufacture **** and utilise **** Manufactured by Chirex Annan in
            the production of **** under the terms of this agreement. Chirex
            Annan understands that Glaxo Operations or another member of the GW
            Group may have contractual commitments with third parties to supply
            **** to Glaxo Operations or other member of the GW Group and shall
            discuss with Glaxo Operations ways in which the production of ****
            by Chirex Annan may be reduced to a level consistent with such other
            commitments. In this respect Chirex Annan agrees that it will not
            without Glaxo Operations' prior written consent Manufacture more
            than **** of **** in 1998 nor more than **** of **** in 1999.
            Portions of this Exhibit have been omitted pursuant to a request for
            confidential treatment. The omitted portions are marked **** and
            have been filed separately with the Commission.

5.    FORECASTS; ORDERS; DELIVERY

      5.1.  For budget purposes Glaxo Operations and Chirex Annan shall meet
            prior to 30 August of each year to discuss forecast volumes for the
            next full Contract Year.

      5.2   Glaxo Operations shall communicate to Chirex Annan by 30 August of
            each year a draft order forecast for the next full Contract Year.
            The budgeted volume shall be broken down month by month (in respect
            of the first six months of any Contract Year) and by Quarter (in
            respect of the second six months of any Contract Year) and in
            respect of each delivery point. The Parties shall discuss at which
            Facility it is appropriate to Manufacture the Product.

      5.3   Glaxo Operations shall place with Chirex Annan a firm written
            confirmatory order specifying the required quantity of Product, the
            date upon which it expects such 


                                       11
<PAGE>   15

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            Product to be available for delivery and the appropriate packaging
            and labelling instructions. Such confirmatory order shall be placed
            at least 30 days prior to the next following Quarter in respect of
            all Product to be Manufactured in that Quarter.

      5.4   Chirex Annan shall have 10 days from the date of receipt of the
            Order to suggest modifications in respect of quantities or delivery
            date, based on order forecasts previously communicated to Chirex
            Annan.

      5.5   Chirex Annan shall deliver or arrange for delivery of Products
            Manufactured hereunder to Glaxo Operation's facility (or such other
            UK site as Glaxo Operations shall indicate not less than 7 days
            before the date of delivery) in accordance with clause 5.3.

6.    TITLE/RISK OF LOSS

      Chirex Annan shall be responsible for loss of Products until delivery to
      Glaxo Operations. Title to Products and risk of loss shall be with Chirex
      Annan until delivery to Glaxo Operations or (in the case of deliveries
      outside the U.K.) to the delivery agent.

7.    PREMISES/PLANT

      7.1   Chirex Annan undertakes to Manufacture Products at either Facility.
            Manufacture of any Product at either Facility shall be subject to
            prior clearance (not to be unreasonably withheld or delayed) by
            Glaxo Operations that the Facility, Manufacturing environment
            therein, plant and services in which and by which the Portions of
            this Exhibit have been omitted pursuant to a request for
            confidential treatment. The omitted portions are marked **** and
            have been filed separately with the Commission. Products will be
            Manufactured meet Glaxo Operations' manufacturing and quality
            assurance requirements.

      7.2   Subject to the provisions of clause 7.1 Glaxo Operations shall not
            be required to approve which Facility Manufactures particular
            Products at any one time provided that Glaxo Operations is notified
            in advance where particular Products are to be Manufactured. However
            if Glaxo Operations reasonably believes that security of 


                                       12
<PAGE>   16

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            supply of particular Products is or could be prejudiced by the
            quantities of Products being Manufactured at one or other of the
            Facilities it shall be entitled to notify Chirex Annan of such
            belief. Glaxo Operations shall be entitled, if it is required to do
            so by any regulations, to require Chirex Annan to move production
            between the Facilities.

8.    COVENANTS AS TO QUALITY AND QUANTITY

      8.1   Chirex Annan undertakes that the Manufacture of the Products
            hereunder shall be carried out in accordance with the Manufacturing
            Instructions and that the Products delivered to Glaxo Operations
            shall be in compliance with the relevant specifications set out in
            the Manufacturing Instructions and (if applicable) approved
            reference samples of such Products. Chirex Annan shall not vary the
            method of Manufacture of any Product without the prior written
            consent of Glaxo Operations. Chirex Annan shall carry out the
            Manufacture of the Products in accordance with CGMP.

      8.2   Glaxo Operations shall notify any non-compliance with specifications
            and/or approved references samples within 30 days of receipt of
            Product. Glaxo Operations undertakes not to process the Product
            unless and until such Product (or, where appropriate, samples
            thereof) have been subject to Glaxo Operations' quality control
            tests and approved as meeting the Manufacturing Instructions. Chirex
            Annan shall have no liability under the provisions of clause 8.1 if
            and to the extent that Glaxo Operations fails to carry out such test
            and such tests would have shown that Chirex Annan was not in
            compliance with its obligations under this agreement including the
            obligation to Manufacture the Products in accordance with the
            Manufacturing Instructions. Glaxo Operations shall notify Chirex
            Annan of any apparent or chemical defect in the Product of which it
            becomes aware whether as a result of its testing requirements for
            pharmaceutical ingredients or otherwise within 30 days of receipt of
            the Product by Glaxo Operations. If Glaxo Operations has given
            notice of any defect in the Product in accordance with this clause
            it shall immediately send a sample of such Product to Chirex Annan
            for cross-checking.


                                       13
<PAGE>   17

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      8.3   In the event that any batch of any Product Manufactured by Chirex
            Annan and delivered to Glaxo Operations shall not comply with the
            relevant specification set out in the Manufacturing Instructions
            and/or approved reference samples of such Product Chirex Annan shall
            make no charge hereunder in respect of that batch provided that
            Chirex Annan shall have the right at its option to re-work or
            re-process the batch at its own expense in accordance with a
            procedure validated by Glaxo Operations if satisfactory recovery or
            utilisation of the Product shall thereby be technically feasible.
            Chirex Annan shall have the right to have the original non-complying
            Product returned to such site as it shall nominate or destroyed.
            Chirex Annan shall reimburse Glaxo Operations for all reasonable
            expenses incurred by Glaxo Operations in returning the defective
            batch to Chirex Annan. Any payment(s) made by Glaxo Operations
            pursuant to clause 3 for such Products shall not prejudice Glaxo
            Operations' rights under this clause.

      8.4   If Glaxo Operations and Chirex Annan do not agree on whether Chirex
            has Manufactured any Product in accordance with clause 8 samples of
            the Product in question will be submitted for testing to an
            independent testing laboratory acceptable to both Parties. The
            determination of such independent laboratory will be binding on both
            Parties. The cost of the testing by the independent laboratory shall
            be borne by the Party whose results differ from those of the
            independent laboratory as to whether the Product in question has not
            been Manufactured in accordance with this clause 8.

      8.5   Glaxo Operations assumes liability for and shall indemnify Chirex
            Annan against any loss, liability or expense which Chirex Annan
            suffers or incurs to the extent that such loss or liability results
            from the Manufacturing Instructions, specifications or other
            requirements of Glaxo Operations under this agreement. Provided that
            this indemnity shall not extend to physical damage suffered by
            Chirex Annan or personal injury to or death of its employees.

9.    SAMPLES; INSPECTIONS

      9.1.  At the request of Glaxo Operations, Chirex Annan shall submit to
            Glaxo Operations 


                                       14
<PAGE>   18

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            samples of such production batches of Products as Glaxo Operations
            shall reasonably request from time to time.

      9.2.  Glaxo Operations shall have the right at Glaxo Operations' cost
            during normal business hours by prior appointment to have an
            appropriately qualified observer reasonably approved by Chirex Annan
            enter either Facility for the purpose of inspecting the Manufacture
            of Products, the storage of Raw Materials and Products in the course
            of Manufacture and, insofar as is necessary to determine if the
            Product is being Manufactured in accordance with Chirex Annan's
            obligations under this agreement, all records and reports relating
            to the Manufacture of the Products. Chirex Annan shall insofar as it
            is able procure such rights of entry and inspection in respect of
            any suppliers of Raw Materials.

      9.3.  Glaxo Operations shall have the right to request Chirex Annan to
            provide samples of Raw Materials and Products in the course of
            Manufacture.

      9.4.  Chirex Annan shall notify Glaxo Operations of the results of,
            observations of, and outcome of all inspections and/or audits of the
            Facilities and/or operations conducted by any Governmental Body
            which is relevant to the Manufacture of the Products.

10.   TECHNICAL ASSISTANCE.

      Glaxo Operations shall provide Chirex Annan upon request by Chirex Annan
      with such technical assistance and instructions as is reasonably necessary
      to enable Chirex Annan to Manufacture Products.

11.   HAZARDS

      Glaxo Operations will provide Chirex Annan with all information in Glaxo
      Operations' possession or which it is obliged to provide by law or under
      regulation relating to known hazards relating to the Manufacture and
      handling of the Products and the handling of the Raw Materials. The
      Parties recognise that Glaxo Operations selected Chirex Annan for the


                                       15
<PAGE>   19

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      Manufacture of Products, inter alia, for Chirex Annan's expertise in
      handling chemicals required in the Manufacture of Products. Chirex Annan
      shall be solely responsible for compliance with all health, safety and
      environmental regulations and guidelines during the Manufacture of
      Products and the storage of Raw Materials and Products prior to delivery
      to Glaxo Operations.

12.   INTELLECTUAL PROPERTY; IMPROVEMENTS

      12.1  All intellectual property rights (which shall include patents,
            patent applications, know-how, designs, copyright and technical
            information) in the Manufacturing Instructions and other information
            relating to the Products disclosed by Glaxo Operations in
            contemplation of or in accordance with this agreement are and shall
            remain the property of Glaxo Operations.

      12.2  Glaxo Operations warrants that it or a member of the GW Group is the
            owner of all intellectual property rights required for the
            Manufacture of the Products under this agreement and that it has the
            right to grant a licence of such rights in accordance with the terms
            of clause 12.3.

      12.3  Under the terms and subject to the conditions of this agreement
            Glaxo Operations grants Chirex Annan a non-exclusive, royalty free,
            non-transferrable, non-sub-licensable right during the term of this
            agreement of all intellectual property rights referred to in clause
            12.1. to make, manufacture and supply Products solely to Glaxo
            Operations and solely to perform Chirex Annan's obligations under
            this agreement. Chirex Annan will have no right or licence to make,
            manufacture, supply, distribute or sell Products, using the
            intellectual property rights licensed to it under this clause for
            any other purpose or for or to any other person nor to make,
            manufacture, supply, distribute or sell any products other than the
            Products. To the extent that Chirex Annan and/or any other company
            in the Chirex Group enters into a direct Contract with **** or one
            of its affiliates in respect of the manufacture and supply of the
            Product **** (see clause 2.4) Chirex Annan shall have the right and
            licence under all intellectual property rights referred to in clause
            12.1 to make, manufacture and supply 


                                       16
<PAGE>   20

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            such Product to **** or one of its affiliates.

      12.4  Each Party shall notify the other of any process improvements that
            it discovers or of which it learns (and in each case, which it is
            free to disclose) relating to the Manufacture of the Products unless
            the party discovering or learning of the improvement has bona fide
            commercial reasons for not wishing to disclose such improvements
            save as is envisaged under clause 3.3. All intellectual property
            rights in such improvements shall (whether or not disclosed) belong
            to Glaxo Operations but:

            12.4.1 if disclosed shall be licensed to Chirex Annan on the terms
                   of clause 12.2; and

            12.4.2 if discovered, or learned of, by Chirex Annan and not being
                   specific to the Products Chirex Annan shall have the right to
                   use such improvements in relation to all products other than
                   the Products.

13.   CONFIDENTIALITY

      13.1. Chirex Annan undertakes for itself and any of its employees having
            access to any of the Manufacturing Instructions relating to the
            Products to use the Manufacturing Instructions only for the purpose
            of Manufacturing Products on behalf of Glaxo Operations and to hold
            the same in confidence and not to disclose the Manufacturing
            Instructions to any other person (other than its affiliates and
            their professional advisers, all of whom shall be instructed to keep
            such information confidential) during the term of this agreement or
            thereafter without the written consent of Glaxo Operations. Chirex
            Annan hereby agrees that the Manufacturing Instructions are and
            shall at all times remain the property of Glaxo Operations and
            Chirex Annan undertakes on the termination of this agreement, unless
            otherwise agreed:

            13.1.1. to cease using the Manufacturing Instructions; and


                                       17
<PAGE>   21

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            13.1.2. not to manufacture the Products using intellectual property
                    rights granted to Chirex Annan under this agreement on 
                    behalf of any third party; and

            13.1.3. to return to Glaxo Operations all documents relating thereto
                    and all copies or reproductions thereof (other than one copy
                    as proof of receipt).

      13.2. Glaxo Operations undertakes for itself and its employees to keep
            confidential all information regarding Chirex Annan's quality
            control procedures, documentation, processes, manufacturing
            practices and all other information acquired by Glaxo Operations in
            connection with this agreement relating to Chirex Annan's plant or
            operations, whether or not relating to Products, not to make any use
            of such information except in connection with its purchase of
            Products hereunder, and not to disclose any such information to any
            other person (other than its affiliates and their professional
            advisers, all of whom shall be instructed to keep such information
            confidential) during the term of this agreement or thereafter
            without the prior written consent of Chirex Annan.

      13.3. Clauses 13.1 and 13.2 shall not apply to any information:

            13.3.1. that is and can be shown to be already known to any member
                    of the GW Group or Glaxo, Operations any member of the 
                    Chirex Group, as the case may be, at the time of disclosure 
                    to such Party under the provisions of this agreement; or

            13.3.2. that is or has been disclosed to Chirex Annan or Glaxo
                    Operations as the case may be, without restriction by any
                    other person entitled to disclose the said information; or

            13.3.3. that is in the public domain or is subsequently disclosed to
                    the public other than by a breach of this agreement; or


                                       18
<PAGE>   22

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            13.3.4  that is required to be disclosed by any court of competent
                    jurisdiction or any governmental or regulatory authority.

14.   CONSENTS

      It is hereby agreed by the Parties that this agreement is made conditional
      upon Chirex Annan obtaining all necessary authorisations and consents and
      completing such formalities as may be required by any governmental or
      ministerial body in order for Chirex Annan to Manufacture and supply the
      Products in accordance with the terms of this agreement. The Parties
      recognise that Glaxo Operations has selected Chirex Annan to carry out the
      Manufacture of Products because inter alia Chirex Annan's premises, plant
      and operations are to a standard that is acceptable to the US Food and
      Drug Administration. Without prejudice to the generality of the foregoing,
      Chirex Annan undertakes to maintain all necessary FDA approvals.

15.   ASSIGNMENT

      15.1  The obligations of Chirex Annan under this agreement may be
            performed by any company within the Chirex Group. Subject to clause
            15.2 Chirex Annan may not at any time delegate, transfer or assign
            all or any part of this agreement or the benefits thereof to any
            person without the prior written consent of Glaxo Operations, and
            Chirex Annan hereby acknowledges that the rights and obligations
            contained herein are solely personal to Chirex Annan.

      15.2  Chirex Annan may assign this agreement to any company within the
            Chirex Group and, upon prior notice to Glaxo Operations to any
            funder of Chirex Annan.

      15.3  Glaxo Operations may not at any time delegate transfer or assign all
            or any part of this agreement or the benefits hereof to any person
            without the prior written consent of Chirex Annan and Glaxo
            Operations hereby acknowledges that the rights and obligations
            contained herein are solely personal to Glaxo Operations. Glaxo


                                       19
<PAGE>   23

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            Operations may with the prior written consent of Chirex Annan (such
            consent not to be unreasonably withheld or delayed) assign this
            agreement to any company within the GW Group.

16.   DURATION

      16.1  Subject to the provisions of clauses 16.2 and 16.3 this agreement
            shall commence on the date first above written and shall continue in
            force until 31 December 2002. This agreement shall be automatically
            renewed by successive periods of 12 months unless terminated by
            either Party at the end of its initial term or at the end of any
            renewal period (in either such case) by 24 months prior written
            notice given to the other Party to that effect and the minimum level
            of orders for any such extended period shall be as agreed between
            the Parties.

      16.2  In addition to any rights to terminate this agreement herein
            elsewhere provided:

            16.2.1 either Party shall have the right to terminate this agreement
                   forthwith by giving written notice to the other Party if the
                   other Party becomes insolvent or goes into liquidation (other
                   than a voluntary liquidation for the purpose of amalgamation
                   or reconstruction) or shall have any form of receiver
                   appointed over the whole or any part of its assets or shall
                   enter into any arrangement or composition with creditors or
                   shall cease business;

            16.2.2 if either Party shall commit or allow to be committed (other
                   than by reason of Force Majeure) a material breach of any of
                   the provisions on its part to be observed and, after written
                   notice from the other Party indicating if there is another
                   material breach it intends to terminate this agreement and
                   such a further material breach arises the other Party shall
                   have the right to terminate this agreement by giving written
                   notice to the defaulting Party provided that in the case of a
                   breach capable of being made good if the defaulting Party
                   shall make good the said breach within 30 days after the said
                   notice shall have been given the said notice shall not be
                   effective;


                                       20
<PAGE>   24

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            16.2.3 if either Party shall commit or allow to be committed (other
                   than by reason of Force Majeure) a material breach of any of
                   the provisions on its part to be observed and, after written
                   notice from the other Party indicating if there is another
                   material breach it intends to terminate this agreement and a
                   further material breach arises in relation to a Product the
                   other Party shall have the right to terminate this agreement
                   in relation to that Product only by giving written notice to
                   the defaulting party provided that in the case of a breach
                   capable of being made good if the defaulting Party shall make
                   good the said breach within 30 days after the said notice
                   shall have been given the said notice shall not be effective.

      16.3  16.3.1 Glaxo Operations may terminate this agreement upon 60 days
                   notice to Chirex Annan upon the occurrence prior to December
                   31, 2002 of a Change in Control of Chirex Annan.

            16.3.2 A "Change in Control of Chirex Annan" shall mean that a party
                   (other than a Permitted Owner and other than Chirex Inc. or
                   any entity controlled by Chirex Inc.) shall have acquired,
                   directly or indirectly, more than 50%, on a fully diluted
                   basis, of the voting securities of Chirex Annan or (as the
                   case may be) Chirex Inc.

            16.3.3 A Permitted Owner means any entity (other than an entity
                   which is itself or through one or more of its affiliates one
                   of the 30 largest pharmaceutical companies, as determined by
                   reference to the most current annual revenues as published by
                   I.M.S.) that

                   16.3.3.1 is experienced in or has senior and operating
                            management, including personnel retained at the 
                            Facility (or other facilities permitted to 
                            Manufacture and supply Products hereunder), who are 
                            experienced in pharmaceutical manufacturing under 
                            CGMPs, including fine chemicals, intermediates and 
                            bulk 


                                       21
<PAGE>   25

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                            activities; and

                   16.3.3.2 has sufficient financial resources and liquidity to
                            satisfy the requirements for working capital
                            necessary to operate such facilities as aforesaid
                            in the manner required to Manufacture and supply
                            Products and perform all the obligations of Chirex
                            Annan under this agreement; and

                   16.3.3.3 is in good standing with the FDA and has for five 
                            years prior to the Change in Control of Chirex had a
                            satisfactory record of regulatory compliance with
                            the FDA and the other applicable Governmental
                            Bodies exercising similar functions except to the
                            extent any non compliance would not reasonably be
                            expected to have a material adverse effect on the
                            ability of such entity to operate facilities of the
                            type described in clause 16.3.3.1; and

                   16.3.3.4 is not (and has no affiliate that is) at the time
                            of the Change of Control of Chirex Annan, or the
                            five year period prior thereto engaged in any
                            litigation or arbitration involving a member of the
                            GW Group or the manufacture of products for the GW
                            Group, in either case only if such litigation or
                            arbitration involves significant amounts to the GW
                            Group.

      16.4. On termination of this agreement Glaxo Operations shall in
            accordance with the terms of this agreement purchase any and all
            stocks of Products which are not defective in the possession of
            Chirex Annan (for which Chirex Annan shall invoice Glaxo Operations
            in accordance with clause 3) and any Raw Materials and intermediates
            purchased by Chirex Annan for the purposes of this agreement and
            which is not excessive to meet Chirex Annan's requirements for stock
            to fulfil its expected obligations under this agreement where such
            excessive stock has not been purchased in good faith by Chirex Annan
            (for which Chirex Annan shall invoice 


                                       22
<PAGE>   26

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            Glaxo Operations the price paid by Chirex Annan for them) Provided
            that Chirex Annan shall be entitled to complete the Manufacture of
            any Product which is in process.

      16.5. The termination of this agreement shall be without prejudice:

            16.5.1. to the obligations of the Parties to remit in full all
                    payments accrued due and payable at the effective date 
                    of such termination;

            16.5.2. to the provisions of Clauses 12, 13, 18 and 19;

            16.5.3 to any other right or remedy available to either Party at
                   such termination.

17.   DENIAL OF RIGHTS

      Nothing herein contained shall be interpreted as granting or be deemed to
      grant Chirex Annan or any member of the Chirex Group any right, title or
      interest of any kind whatsoever in or under any patent claiming any of the
      Products.

18.   PRODUCT COMPLAINTS; ADVERSE EVENT REPORTS

      18.1. Chirex Annan acknowledges that Glaxo Operations shall be solely
            responsible for receiving, recording and responding to all customer
            enquiries and complaints and all reports of alleged adverse events
            relating to the final products which are produced from the Products.
            In so responding Glaxo Operations shall have due regard to the
            reputation and commercial interests of Chirex Annan. Glaxo
            Operations shall be solely responsible for reporting all such
            matters to Governmental Bodies in accordance with applicable laws.
            Chirex Annan shall provide Glaxo Operations with any technical
            information relating to investigations, and Manufacture of the
            Products reasonably necessary to enable Glaxo Operations to perform
            such obligations.


                                       23
<PAGE>   27

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      18.2  The provisions of clause 18.1 shall survive expiration or
            termination of this agreement.

19.   INDEMNITIES

      19.1. Chirex Annan shall be liable for and shall indemnify Glaxo
            Operations against any loss, claim, damage, expense, or liability
            arising out of;

            19.1.1. any breach of the terms of the agreement by Chirex Annan,
                    including without limitation any failure to Manufacture the
                    Products in accordance with this agreement;

            19.1.2. any negligence, storage or handling of the Products by
                    Chirex Annan prior to delivery to Glaxo Operations; and

            19.1.3. any wilful act or omission of Chirex Annan or its employees,
                    agents or other contractors with respect to the Products.

      19.2. Glaxo Operations shall be liable for and shall indemnify Chirex
            Annan against any loss, claim, damage, expense or liability arising
            out of:

            19.2.1 any infringement of any third party intellectual property
                   arising from Chirex Annan's Manufacture of the Products in
                   accordance with the provisions of this agreement;

            19.2.2 the marketing and the sale of the Products (or products into
                   which the Products are incorporated) provided that Glaxo
                   Operations shall not be required to indemnify Chirex Annan in
                   accordance with the foregoing to the extent that Chirex Annan
                   is obliged to indemnify Glaxo Operations pursuant to the
                   provisions of clause 19.1

            19.2.3 the handling or use of the Product following delivery by 
                   Chirex Annan.


                                       24
<PAGE>   28

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


      19.3. Where one Party ("the Indemnifier") is required to indemnify the
            other ("the Indemnified") in accordance with clause 8.5 or this
            clause 19 it shall be a condition of such Indemnity that:

            19.3.1. the Indemnified promptly notifies the Indemnifier in writing
                    of the claim or the threat of a claim;

            19.3.2 the Indemnified accepts and acts upon the reasonable requests
                   of the Indemnifier as to the manner in which and the means by
                   which the claim or threat is dealt with; and

            19.3.3 the Indemnified shall not have compromised the position by
                   unnecessary admissions or statements or conduct in a way
                   which could prejudice the defence of any such claim or
                   threat.

20.   INSURANCE

      20.1. Unless otherwise agreed in writing, Chirex Annan shall, at its own
            expense, carry and maintain during the term of this agreement the
            following insurance's under policies and with companies satisfactory
            to Glaxo Operations and in amounts per event no less than that
            specified for each type:-

            20.1.1. Public Liability Insurance for a sum assured of not less
                    than (pounds)1,000,000 (one million pounds); and

            20.1.2. Product Liability Insurance for sum assured of not less than
                    (pounds)5,000,000 (five million pounds).

      20.2  On request Chirex Annan shall have its insurance carrier or carriers
            furnish to Glaxo Operations certificates that all insurance required
            under this agreement is in force, such certificates to indicate any
            deductible and/or self-insured retention and stipulate 


                                       25
<PAGE>   29

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            that the insurance will not be cancelled while this agreement is in
            effect without (prior written notice to Glaxo Operations. Chirex
            Annan shall on request permit Glaxo Operations to examine original
            insurance or other protective policies issued in compliance with the
            requirements hereof. Should Chirex Annan at any time neglect or
            refuse to provide or cause not to be provided the insurance required
            herein, or should such insurance be cancelled, Glaxo Operations
            shall have the right to procure the same and the cost thereof shall
            be deducted from monies then due or thereafter to become due to
            Chirex Annan.

21.   FORCE MAJEURE

      Any failure or delay in performance hereunder shall be excused if and to
      the extent such failure or delay is due to Force Majeure; provided that
      the Party seeking to excuse its performance shall (a) promptly notify the
      other Party of the cause therefor and (b) use its best efforts to remedy
      or remove the cause therefor. Neither Party shall have the right or action
      against the other for any failure or delay. If the performance of any
      material obligation under this agreement is delayed or prevented owing to
      Force Majeure for any continuous period of more than 6 months, the Party
      not affected by such Force Majeure shall have the right to terminate this
      agreement by serving written notice to that effect on the other party.

22.   NOTICES

      Any notice or consent required to be given by either Party shall be
      addressed in writing to the company secretary of the Party for whom it is
      intended at the address listed on the first page hereof (or such other
      address as a party may from time to time designate by written notice) and
      shall be deemed to have been duly served at the time that it would have
      been received in the ordinary course of post. Any notice served on Chirex
      Annan shall be copied to the Managing Director and Finance Director at
      Chirex Dudley Limited, Dudley, Cramlington, Northumberland NE23 7QG.


                                       26
<PAGE>   30

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


23.   DISPUTE RESOLUTION

      The Parties shall endeavour to settle amicably any dispute between them of
      a financial nature arising in connection with this agreement. If no
      amicable settlement can be arrived at within a reasonable time period then
      either Party may refer such matter to an independent firm of Chartered
      Accountants nominated jointly by them or if no such nomination is made
      within 14 days after the expiry of one Party requiring nomination,
      nominated at the request of either of them by the President for the time
      being of the Institute of Chartered Accountants in England and Wales. The
      Accountants so nominated shall be entitled to ask for and inspect the
      working papers, records and documents of both Parties as they may
      reasonably consider necessary. In making their determination, the said
      Accountants shall act as experts and not as arbitrators, their decision
      shall (in the absence of manifest error) be final and binding on the
      Parties and their fees shall be borne and paid by the Parties in such
      proportions as the Accountants determine in the light of the respective
      contentions of the Parties, and the Accountants' determination.

24.    PUBLICITY

      Neither Party shall issue any press release or other publicity materials
      or make any representation with respect to the existence of this agreement
      or the subject matter thereof without the prior written consent of the
      other Party. However, this restriction shall not apply to announcements
      required by law or regulation or the regulations of any recognised stock
      exchange or under the requirements of the U.S. Securities Act 1933 and the
      Securities Exchange Act 1934 except that in such event the Parties shall
      co-ordinate to the extent possible with respect to the wording of any such
      announcement.

25.   CONTRACT ADMINISTRATION


      25.1  The Parties shall establish points of contact for, respectively,
            matters of a commercial nature and a technical/quality nature
            relating to the performance of this agreement to whom matters will
            be referred in the first instance. Such points of contact may be


                                       27
<PAGE>   31

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


            changed at any time by either Party on notification of such change
            to the other Party.

      25.2  Through their nominated representatives the Parties shall meet on
            such basis as shall be agreed from time to time (but no less than
            quarterly) to discuss Glaxo Operations' forecast for the Products
            and production matters relating to delivery of Products requested by
            Glaxo Operations.

26.   LIABILITY

      In no event shall the aggregate liability of Chirex Annan or any other
      member of the Chirex Group under this agreement exceed (pounds)10,000,000
      (ten million pounds) in any period of 12 months.

27.   WAIVER

      The failure on the part of either Party to exercise or enforce any right
      conferred upon it shall not be deemed to be a waiver of any such right or
      operate to bar the exercise or enforcement thereof at any time or times
      thereafter.

28.   CONSENT TO JURISDICTION

      With respect to any suit, action or proceeding relating to this agreement,
      each Party irrevocably submits to the jurisdiction of the English courts
      and waives any objection which it may have any time to laying of venue of
      any proceedings brought in any such court. Each party irrevocably consents
      to service of process given in the manner for notices in clause 22.

29.   ENTIRETY

      This agreement constitutes the entire agreement between the Parties
      relating to Manufacture of the Products, and this agreement shall not be
      considered cancelled or amended in any respect unless done so in writing
      signed on behalf of the Parties.


                                       28
<PAGE>   32

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


30.   LAW

      This agreement shall be construed and have effect in all respects in
      accordance with English law.

31.   SUCCESSORS AND ASSIGNS

      This agreement shall be binding upon and enure for the benefit of both
      Parties and their successors and permitted assigns as the case may be.

32.   PARTIES

      Chirex Holdings is a party to this agreement only to receive the benefit
      of clause 15.

As WITNESS the hands of the duly authorised signatories on behalf of the Parties
the day and year first above written.


                                       29
<PAGE>   33

                                   SCHEDULE 1

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------------------------------------------
                     1997                                  1998                                   2000                             
                     ----                                  ----                                   ----                             
Products     tns     (pounds)/kg     (pounds)m     tns     (pounds)/kg     (pounds)m     tns     (pounds)/kg     (pounds)m     tns 
- --------     ---     -----------     ---------     ---     -----------     ---------     ---     -----------     ---------     --- 
<S>          <C>     <C>             <C>           <C>     <C>             <C>           <C>     <C>             <C>           <C>


****

<CAPTION>
                2001                                   2001                                 2002
                ----                                   ----                                 ----
Products        (pounds)/kg     (pounds)m     tns     (pounds)/kg     (pounds)m     tns     (pounds)/kg     (pounds)m
- --------        -----------     ---------     ---     -----------     ---------     ---     -----------     ---------
<S>             <C>             <C>           <C>     <C>             <C>           <C>     <C>             <C>

****

                                                       )                                    )


                                                       )                                    )

                                                       )                                     )

                                                       )                                     )
</TABLE>


                                       30
<PAGE>   34

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 2

Key Materials

            Material                Initial designated supplier
            --------                ---------------------------

            ****                          ****


                                       31
<PAGE>   35

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 3

                Notional Capacity Requirements (see clause 2.6.3)

Product           Contract Year    Notional capacity at
- -------           -------------    Commencement of Contract
                                   Year (tpa)
                                   ------------------------

                                   Annan             Dudley
                                   -----             ------

****              1998             ****              ****

                  1999

                  2000

                  2001

                  2002


                  1998

                  1999

                  2000

                  2001

                  2002


                  1998

                  1999

                  2000

                  2001

                  2002


                                       32
<PAGE>   36

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                  1998

                  1999

                  2000

                  2001

                  2002


                  1998

                  1999

                  2000

                  2001

                  2002


                  1998

                  1999

                  2000

                  2001

                  2002


                  1998

                  1999

                  2000

                  2001

                  2002


                                       33
<PAGE>   37

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


                                   SCHEDULE 4
                            Formula for Profit Share

In the event of additional volume to that set out in Schedule 1. (Both in
respect of Firm Commitment and Intended Quantities.)

Profit share will be based on:- **** of

Additional turnover less direct cost and engineering and development costs.

                        Existing Products      New Products
                        -----------------      ------------


Direct cost defined as:-

                        ****% Raw Materials    ****% Raw Materials


                        ****% Labour           ****% Labour


                        ****% Utilities and    ****% Utilities and
                        Consumables            Consumables

                                               ****% Depreciation


SIGNED by David Pulman        )
on behalf of                  )     /s/ D. Pulman
GLAXO OPERATIONS UK           )
LIMITED in the presence of:   )

/s/ P.R. Jones    

P.R. Jones
Solicitor

SIGNED by Alan R. Clark       )
on behalf of                  )     /s/ A.R. Clark
CHIREX (ANNAN) LIMITED        )
in the presence of:           )


                                       34
<PAGE>   38

Portions of this Exhibit have been omitted pursuant to a request for
confidential treatment. The omitted portions are marked **** and have been filed
separately with the Commission.


SIGNED by Alan R. Clark       )
on behalf of                  )     /s/ A.R. Clark
CHIREX (HOLDINGS)             )
LIMITED                       )
in the presence of:           )


                                       35

<PAGE>   1
                              [ChiRex Letterhead]


CONTACTS FOR CHIREX:                         CONTACT FOR GLAXO
                                             WELLCOME MEDIA ENQUIRIES:

IN THE U.S.
Michael A. Griffith                          Nancy Pekarek
Chief Financial Officer                      Communications Manager
ChiRex Inc.                                  London
(203) 351-2300                               011-44-171-493-4060

Douglas MacDougall
Feinstein Kean Partners Inc.
(617) 577-8110

IN THE U.K.
Alan R. Clark
Chairman and CEO
ChiRex Inc.
011-44-191-250-0471

FOR IMMEDIATE RELEASE


                  CHIREX COMPLETES PURCHASE OF GLAXO WELLCOME
                   MANUFACTURING FACILITY AT ANNAN, SCOTLAND


       - ChiRex to Initiate Manufacturing Under Five Year Supply Contract
                     Valued at Approximately $450 million -


Stamford, Connecticut and Dudley, Northumberland, England, October 31, 1997 --
ChiRex Inc. (Nasdaq: CHRX), a leading pharmaceutical Contract Manufacturing
Organization, and Glaxo Wellcome plc announced today that ChiRex has completed
its purchase of Glaxo Wellcome's FDA cGMP pharmaceutical production facility at
Annan, Scotland. Glaxo Wellcome has received $66 million (Pound Sterling 40
million) for the facility and ChiRex will initiate the manufacture of certain
Glaxo pharmaceutical intermediates and active ingredients under a five year
contract valued at approximately $450 million.

"We have begun a period of collaboration with ChiRex, building on our
association over the last 15 years," said David Pulman, Ph.D., Director of
International Actives Supply, Glaxo Wellcome. "Through this relationship, Glaxo
Wellcome has access to the ChiRex organization and its combination of
manufacturing expertise and innovative technologies." Dr. Pulman noted that
Glaxo Wellcome has been working with ChiRex management to achieve a smooth
transition at the Annan site, and all staff members have been transferred to
ChiRex as of today.

"The completion of this Glaxo Wellcome agreement supports ChiRex's plans in
several ways," said Alan R. Clark, Chairman and CEO of ChiRex. "Financially,
the manufacturing contract ensures a major revenue stream beginning in this
fiscal year and continuing into the next decade. Operationally, the facility
significantly expands our capacity. Strategically, it positions us solidly in
the next generation of higher-value-added pharmaceuticals, and enables us to
accelerate the use of ChiRex's proprietary technologies by the world's major
pharmaceutical companies."

                                     -more-

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             ChiRex Inc. Announces the Completion of the Annan Facility Purchase
                                                                           Page2

Mr. Clark added that ChiRex already has appointed managers for key positions
and commenced the integration of the Annan employees, as well as meeting with
regulatory agencies and beginning the reconfiguration of the facilities.

ChiRex has purchased all of the buildings, land and equipment at the 154-acre
Annan, Scotland, property, encompassing three main production buildings, for
pound sterling 40 million (approximately $66 million), plus certain working
capital. Under the agreement, ChiRex will continue to manufacture most of the
products currently made at Annan and plans to invest pound sterling 30 million
(approximately $48 million) over five years to accommodate newly contracted
products and to modify the facility for general purpose manufacturing.

ChiRex is a Contract Manufacturing Organization serving the outsourcing needs
of the pharmaceutical industry through its extensive pharmaceutical fine
chemical manufacturing, process development capabilities and proprietary chiral
technologies. The Company supports and supplements the in-house development
and manufacturing capabilities of its pharmaceutical and biotechnology
customers with a broad range of fully-integrated services, accelerating the
time from drug discovery to commercialization. ChiRex currently produces over
50 products in its two world-class, FDA cGMP manufacturing facilities in
Dudley, Northumberland, England and in Annan, Scotland. ChiRex holds 54 patents
and patent applications in the field of chiral chemistry.

Glaxo Wellcome is a research-based company committed to fighting disease by
bring innovative medicines and services to patients throughout the world and to
the healthcare providers who serve them.

Any statements contained in this release that relate to future plans, events 
or performance, are forward-looking statements that involve risks and
uncertainties, including, but not limited to, product development and market
acceptance risks, product manufacturing risks, the impact of competitive
products and pricing, the results of current and future licensing and other
collaborative relationships, the results of financing efforts, developments
regarding intellectual property rights and litigation, risks of product
non-approval or delays or post-approval reviews by the FDA or foreign regulatory
authorities, and other risks identified in the ChiRex Inc.'s Securities and
Exchange Commission filings. Actual results, events or performance may differ
materially. Readers are cautioned not to place undo reliance on these
forward-looking statements, which speak only as the date hereof. ChiRex
undertakes no obligation to publicly release the results of any revisions to
these forward-looking statements that may be made to reflect events or
circumstances after the date hereof or to reflect the occurrence of
unanticipated events.


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