CHIREX INC
10-Q, 1998-11-16
PHARMACEUTICAL PREPARATIONS
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<PAGE>
 
                                                                        Draft
                                                                        11/12/98
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 10-Q

       QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
                              EXCHANGE ACT OF 1934

        For the quarterly period                   Commission File number 
        ended September 30, 1998                         0 - 27698

                                   CHIREX INC.
             (Exact name of registrant as specified in its charter)


           DELAWARE                                   04-3296309
 (State or other jurisdiction of            (I.R.S. Employer Identification No.)
 incorporation or organization)

     300 Atlantic Street
          Suite 402
    Stamford, Connecticut                                  06901
(Address of principle executive office)                  (Zip Code)

                                 (203) 351-2300
              (Registrant's telephone number, including area code)



Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to
filing requirements for the past 90 days.


Yes    X      No    
     ----        ---


Number of shares outstanding of the issuer's classes of common stock as of
November 13, 1998.



           Class                                Number of Shares Outstanding
- --------------------------------------          ----------------------------
Common Stock, par value $.01 per share                  11,850,461

                                       1
<PAGE>
 
                                  CHIREX INC.

                                     INDEX

<TABLE>
<CAPTION>
                                                                                                      PAGE NUMBER
     
PART I.       FINANCIAL INFORMATION
<S>        <C>                                                                                     <C>
              Item 1.  Financial Statements

                       Consolidated Balance Sheets
                       December 31, 1997 and September 30, 1998                                              3

                       Consolidated Statements of Operations and Comprehensive Operations
                       for the nine-month periods ended September 30, 1997 and 1998                          4

                       Consolidated Statements of Cash Flows for the
                       nine-month periods ended September 30, 1997 and 1998                                  5

                       Notes to Consolidated Interim Financial Statements                                    6


              Item 2.  Management's Discussion and Analysis of
                       Financial Condition and Results of Operations                                         8


PART II.      OTHER INFORMATION

              Item 4.  Submission of Matters to a Vote of Security Holders.                                 12

              Item 5.  Other Information                                                                    12

              Item 6.  Exhibits and Reports on Form 8-K                                                     12

              SIGNATURE                                                                                     12

</TABLE>

   This Quarterly Report on Form 10-Q contains forward-looking statements. For
this purpose, any statements contained herein that are not statements of
historical fact may be deemed to be forward-looking statements. Without limiting
the foregoing, the words "believes," "anticipates," "plans," "expects," and
similar expressions are intended to identify forward-looking statements. Many
important factors could cause actual results to differ materially from those
indicated by forward-looking statements made herein and presented elsewhere by
management from time to time.

                                       2
<PAGE>
 
                         PART I - FINANCIAL INFORMATION
                                     ITEM 1
                              FINANCIAL STATEMENTS

                                   CHIREX INC.
                           CONSOLIDATED BALANCE SHEETS
                 AS OF DECEMBER 31, 1997 AND SEPTEMBER 30, 1998
                 (dollars in thousands except per-share amounts)

<TABLE>
<CAPTION>
 
                                                                                DECEMBER 31,            SEPTEMBER 30,
                                                                                   1997                     1998
                                                                               -------------            -------------
                                                                                                         (unaudited)
<S>                                                                            <C>                      <C>   
ASSETS                                                                                          
- ------                                                                                          
                                                                                                
Current Assets:                                                                                 
       Cash                                                                      $   5,347               $   5,172
       Trade and other receivables                                                  18,811                  22,098
       Inventories                                                                  23,225                  31,112
       Other current assets                                                          3,774                   5,170
                                                                                 ---------               --------- 
            Total current assets                                                    51,157                  63,552
Property, plant and equipment, net                                                 120,755                 144,810
Other non-current assets                                                             3,591                   2,734
Intangible assets, net                                                              27,564                  26,689
                                                                                 ---------               --------- 
       TOTAL ASSETS                                                              $ 203,067               $ 237,785
                                                                                 =========               ========= 
                                                                                                         
LIABILITIES AND STOCKHOLDERS' EQUITY                                                                     
- ------------------------------------                                                                     
                                                                                                         
Current Liabilities:                                                                                     
       Accounts payable                                                          $   8,763               $  23,925
       Accrued expenses                                                             11,587                  11,046
       Income taxes payable                                                            348                       -
       Current portion of long-term debt                                             7,311                  15,111
                                                                                 ---------               --------- 
            Total current liabilities                                               28,009                  50,082
Long-term debt                                                                      69,675                  78,389
Deferred income taxes                                                                7,955                  10,078
Deferred income                                                                      4,333                   5,661
Contingencies                                                                            -                       -
                                                                                 ---------               --------- 
       Total liabilities                                                           109,972                 144,210
                                                                                 ---------               --------- 
                                                                                                         
Stockholders' equity:                                                                                    
       Common stock ($.01 par value, 30,000,000 shares authorized,                                       
            11,792,990 and 11,833,711 shares issued and outstanding on                                   
            December 31, 1997 and September 30, 1998, respectively)                    118                     118
       Additional paid-in capital                                                  100,788                 101,731
       Retained earnings                                                           (11,411)                (12,642)
       Cumulative translation adjustment                                             3,600                   4,368
                                                                                 ---------               --------- 
            Total stockholders' equity                                              93,095                  93,575
                                                                                 ---------               --------- 
       TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                                $ 203,067               $ 237,785
                                                                                 =========               ========= 
</TABLE>

The accompanying notes are an integral part of the consolidated financial
statements.

                                       3
<PAGE>
 
                                   CHIREX INC.
                    CONSOLIDATED STATEMENTS OF OPERATIONS AND
               CONSOLIDATED STATEMENTS OF COMPREHENSIVE OPERATIONS
                FOR THE THREE-MONTH AND NINE-MONTH PERIODS ENDED
                           SEPTEMBER 30, 1997 AND 1998
                                   (unaudited)
                    (in thousands, except per-share amounts)

<TABLE>
<CAPTION>
                                                                    Three Months Ended                   Nine Months Ended
                                                                       September 30                         September 30
                                                           ---------------------------------     ---------------------------------
                                                                 1997              1998               1997               1998
                                                           --------------     --------------     -------------     ---------------
<S>                                                        <C>                <C>                <C>               <C> 
CONSOLIDATED STATEMENTS OF OPERATIONS

Revenues:
      Product sales                                             $ 21,411           $ 31,640          $ 67,691           $ 83,600
      License fee and royalty income                                 194                 75               577                327
                                                           --------------     --------------     -------------     --------------
                 Total revenues                                   21,605             31,715            68,268             83,927
                                                           --------------     --------------     -------------     --------------
                                                                                                                   
Costs and expenses:                                                                                                
      Cost of goods sold                                          16,319             24,866            51,097             65,624
      Selling, general and administrative                          1,885              2,844             6,451              9,121
      Research and development                                       912                953             2,993              3,239
      Restructuring and other expenses net                                                                         
           of proceeds from disposition in 1997                        -              2,802             6,593              3,023
                                                           --------------     --------------     -------------     --------------
                 Total costs and expenses                         19,116             31,465            67,134             81,007
                                                           --------------     --------------     -------------     --------------
                                                                                                                   
Operating profit                                                   2,489                250             1,134              2,920
                                                                                                                   
Interest expense - net                                                11             (1,054)              (64)            (3,883)
Amortization of goodwill                                            (291)              (291)             (873)              (873)
                                                           --------------     --------------     -------------     --------------
                                                                                                                   
Income (loss) before income taxes                                  2,209             (1,095)              197             (1,836)
Benefit (provision) for income taxes                                (609)               351               (93)               605
                                                                                                                   
                                                           --------------     --------------     -------------     --------------
Net income (loss)                                               $  1,600           $   (744)         $    104           $ (1,231)
                                                           ==============     ==============     =============     ==============
                                                                                                                   
Weighted average number of common shares outstanding              11,534             11,817            11,279             11,808
                                                           ==============     ==============     =============     ==============
Weighted average number of common shares                                                                           
      and common stock equivalents outstanding                    11,803             11,817            11,548             11,808
                                                           ==============     ==============     =============     ==============
                                                                                                                   
Net income (loss) per common share:                                                                                
      Basic                                                     $   0.14           $  (0.06)         $   0.01           $  (0.10)
                                                           ==============     ==============     =============     ==============
      Diluted                                                   $   0.13           $  (0.06)         $   0.01           $  (0.10)
                                                           ==============     ==============     =============     ==============
                                                                                                                   
CONSOLIDATED STATEMENTS OF COMPREHENSIVE OPERATIONS                                                                
                                                                                                                   
Net income (loss)                                               $  1,600           $   (744)         $    104           $ (1,231)
                                                                                                                   
Change in cumulative translation adjustment                       (1,219)               818            (2,591)               768
                                                                                                                   
                                                           ==============     ==============     =============     ==============
Comprehensive net income (loss)                                 $    381           $     74          $ (2,487)          $   (463)
                                                           ==============     ==============     =============     ==============
</TABLE>


The accompanying notes are an integral part of the consolidated financial
statements.

                                       4
<PAGE>
 
                                  CHIREX INC.
                     CONSOLIDATED STATEMENTS OF CASH FLOWS
         FOR THE NINE-MONTH PERIODS ENDED SEPTEMBER 30, 1997 AND 1998
                                  (UNAUDITED)
                                (in thousands)

<TABLE>
<CAPTION>
                                                                                        Nine Months Ended
                                                                                          September 30
                                                                          --------------------------------------------
                                                                                1997                       1998
                                                                          ------------------         -----------------
<S>                                                                       <C>                        <C> 
Cash flows from operating activities:
      Net income (loss)                                                             $   104                  $ (1,231)
      Adjustments to reconcile net income (loss) to cash provided
           by operating activities:
           Depreciation & amortization                                                7,054                     9,250
           Deferred tax provision                                                       294                     1,864
           Restructuring and impairment charge                                        8,391                     3,023
           Proceeds from sale of acetaminophen business                              (6,308)                        -
           Changes in assets and liabilities:
                Receivables                                                          (1,812)                   (2,572)
                Inventories                                                          (2,564)                   (7,693)
                Other current assets                                                   (936)                    1,391
                Accounts payable and accrued expenses                                (5,973)                   10,851
                Income taxes payable                                                  1,893                    (2,010)
                Deferred income                                                        (298)                    1,161
                Other non-current assets and liabilities                                (33)                        -
                                                                          ------------------         -----------------
      Net cash provided from operating activities                                      (188)                   14,034
                                                                          ------------------         -----------------

Cash flows from investing activities:
      Proceeds from disposition of acetaminophin business                             4,100                         -
      Capital expenditures                                                           (6,767)                  (28,277)
                                                                          ------------------         -----------------
      Net cash used in investing activities                                          (2,667)                  (28,277)
                                                                          ------------------         -----------------

Cash flows from financing activities:
      Borrowings on line of credit and revolving credit facility, net                  (839)                   13,435
      Proceeds from issuance of stock                                                 4,180                         -
      Proceeds from exercise of stock options                                           914                       530
                                                                          ------------------         -----------------
      Net cash provided from financing activities                                     4,255                    13,965
                                                                          ------------------         -----------------

Effect of exchange rate changes on cash                                                 254                       103
                                                                          ------------------         -----------------

Net increase (decrease) in cash                                                       1,654                      (175)
Cash at beginning of period                                                             291                     5,347
                                                                          ------------------         -----------------
Cash at end of period                                                               $ 1,945                   $ 5,172
                                                                          ==================         =================
</TABLE>



The accompanying notes are an integral part of the consolidated financial
statements.

                                       5
<PAGE>
 
                                  CHIREX INC.
              NOTES TO CONSOLIDATED INTERIM FINANCIAL STATEMENTS


1.  NATURE OF OPERATIONS AND PRINCIPLES OF CONSOLIDATION


NATURE OF OPERATIONS


    ChiRex Inc. (the "Company" or "ChiRex") serves the outsourcing needs of some
of the largest pharmaceutical and life science companies in the world by
providing pharmaceutical fine chemical manufacturing and process development
services and offering its customers access to the Company's extensive portfolio
of proprietary technologies.  The Company's contract manufacturing services
developed over the past thirty years, include process research and development,
hazard evaluation, clinical quantity production and pilot-scale and commercial-
scale manufacturing at its world-class, current Good Manufacturing Practices
("cGMP") facilities in Dudley, England and Annan, Scotland.  The Company's
common stock is publicly traded in the United States on the Nasdaq Stock
Market's National Market ("NASDAQ") under the symbol "CHRX".


PRINCIPLES OF CONSOLIDATION


    The financial statements of the Company include the historical results of
its subsidiaries for the entire period presented or from the date of
acquisition.

    The interim financial statements, in the opinion of management, reflect all
adjustments (including normal recurring adjustments) necessary for a fair
presentation of the results for the interim period ended September 30, 1998.
The results of operations for the interim period are not necessarily indicative
of the results of operations expected for the fiscal year.

    See Form 10-K filed as of and for the year ended December 31, 1997 for
additional information.

2.  RECENT ACCOUNTING DEVELOPMENTS:

Net Loss per Common Share


    Basic income (loss) per common share for the third quarter and nine-month
periods ended September 30, 1997 and 1998 were computed by dividing the net
income (loss) by the weighted average shares outstanding during the period in
accordance with Statement of Financial Accounting Standards No. 128, Earnings
per Share ("SFAS 128").  Since the effect of the assumed exercise of stock
options of 503,000 shares and 530,000 shares for the third quarter and first
nine months of 1998, respectively, were anti-dilutive, basic and diluted 
loss per common share as presented on the statement of operations are the
same.  Upon adoption of SFAS 128 at year-end 1997, the Company's reported
earnings per common share for the third quarter and first nine months of 1997
were required to be restated.  There was no effect on net income (loss) per
common share for the third quarter and first nine months of 1997 from the
adoption of SFAS 128.

Comprehensive Income

    In June 1997, the Financial Accounting Standards Board issued Statement of
Financial Accounting Standards No. 130, "Reporting Comprehensive Income" ("SFAS
130").  This statement establishes standards for reporting and display of
comprehensive income and its components.  Components of comprehensive income are
net income and all other non-owner changes in equity such as the change in the
cumulative translation adjustment.  This statement requires that an enterprise:
(a) classify items of other comprehensive income by their nature in a financial
statement and (b) display the accumulated balance of other comprehensive income
separately from retained earnings and additional paid-in capital in the equity
section of a balance sheet.  SFAS 130 is effective for financial statements
issued for periods beginning after December 15, 1997.  Presentation of
comprehensive income for earlier periods provided for comparative purposes is
required and has been presented in these financial statements.

                                       6
<PAGE>
 
3.  

    As of September 30, 1998, the Company was not in compliance with certain 
financial covenants of its revolving-credit and term-loan credit facilities (the
"Facilities Agreement"). The lenders have permanently waived these defaults and
the Company has agreed to certain modifications to the Facilities Agreement.
After taking into consideration the waivers and modifications to the Facilities
Agreement, the Company is in compliance with all of the terms of the Facilities
Agreement at September 30, 1998. Under the Company's current business plan,
management expects the Company will be unable to satisfy certain financial
covenants in the future, however the Company has received an unconditional
letter from its lenders expressing their intent to continue their support of the
Company and to negotiate in good faith, further modifications to the Facilities
Agreement as necessary.

4.

    The Company announced in July 1998, a restructuring including management
changes and the transition to a product management structure. The Company
expects to record a total pre-tax restructuring charge of $4.9 million in 
fiscal-year 1998 related to severance and other costs of this restructuring, of
which $2.8 million has been recognized for expenses incurred in the quarter
ended September 30, 1998 with the balance expected to be recognized in the
fourth quarter. Third quarter 1998 restructuring expenses include severance
costs related to management changes made to implement the product management
structure. As of September 30, 1998 approximately $1.8 million of this
restructuring charge is reflected in accrued expenses on the balance sheet.

5.  RECLASSIFICATION

    Certain amounts in the prior period's financial statements have been
reclassified to be consistent with the current period presentation.


                                       7
<PAGE>
 
Item 2
MANAGEMENT'S DISCUSSION AND ANALYSIS OF
FINANCIAL CONDITION AND RESULTS OF OPERATIONS

    The following discussion and analysis should be read in conjunction with the
historical consolidated financial statements and the notes thereto included
elsewhere herein.

INTRODUCTION

    ChiRex Inc. (the "Company" or "ChiRex") serves the outsourcing needs of some
of the largest pharmaceutical and life science companies in the world by
providing pharmaceutical fine chemical manufacturing and process development
services and offering its customers access to the Company's extensive portfolio
of proprietary technologies.  The Company's contract manufacturing services
developed over the past thirty years, include process research and development,
hazard evaluation, clinical quantity production and pilot-scale and commercial-
scale manufacturing at its world-class, current Good Manufacturing Practices
("cGMP") facilities in Dudley, England and Annan, Scotland.

    In April 1997, the Company disposed of its acetaminophen (paracetamol, an
over-the-counter analgesic) business and in September 1997, the Company ceased
production of acetaminophen.  At the time of the disposition, acetaminophen was
the largest volume product manufactured by the Company, representing
approximately 31% of the Company's 1996 pro-forma revenues, but was not highly
profitable at the gross margin level.  In connection with the disposition of the
business, the Company recorded a $6.6 million pre-tax restructuring charge net
of proceeds on disposition in the second quarter of 1997, and implemented
measures designed to offset the effect of the disposal on operating performance.
The Company's decision to dispose of its acetaminophen business followed a
strategic review of several alternatives and was based on a number of factors,
including the continued domination of the acetaminophen business by high volume,
low cost manufacturers and the Company's expectation that the market price of
acetaminophen would continue to erode.

    On October 31, 1997, the Company completed the purchase of a Glaxo Wellcome
FDA cGMP pharmaceutical production facility located in Annan, Scotland.  The
Company paid approximately $66.8 million (40.0 million) for the facility plus an
additional payment for certain working capital of approximately $1.7 million
((Pounds)1.0 million).  As part of the transaction, Glaxo Wellcome awarded the
Company a five-year contract to supply certain pharmaceutical intermediates and
active ingredients with an aggregate sales value of approximately $450 million.
Under the Asset Purchase Agreement, ChiRex purchased all of the buildings, land
and equipment at the 154-acre Annan, Scotland property, encompassing three main
production facilities plus certain working capital.  The Company plans to invest
approximately $25 million over two years to accommodate newly contracted
products and to modify the facility for multi-product pharmaceutical fine
chemical manufacturing.  Under the Supply Agreement, ChiRex will manufacture up
to ten products at Annan and Dudley.  The acquisition has been accounted for as
a purchase and, accordingly, the operating results of the Annan facility have
been included in the Company's consolidated financial statements from the date
of acquisition.

    Substantially all of the Company's revenues and expenses are denominated in
Great Britain pounds sterling, and to prepare the Company's financial statements
such amounts are translated into U. S. dollars at average exchange rates in
accordance with generally accepted accounting principles.

                                       8
<PAGE>
 
RESULTS OF OPERATIONS

Three-month period ended September 30, 1997 and 1998

    Total revenues increased $10.1 million, or 46.8% to $31.7 million in the
third quarter of 1998, from $21.6 million in the comparable period in 1997, as
new products came on stream and shipments under the Glaxo Wellcome supply
contract expanded, partly offset by the unfavorable effect on revenues from the
sale of the acetaminophen business which contributed $4.9 million in revenues in
the third quarter of 1997.

    Cost of goods sold increased $8.5 million, or 52.4% to $24.9 million in the
three-month period ended September 30, 1998 from $16.3 million in last year's
third quarter.  This increase is due to the higher volume of new product sales
partly offset by lower acetaminophen sales, expenses associated with new product
introductions and the under-utilization of the Annan facility acquired in the
fourth quarter of 1997 during its re-conditioning into a multi-product  
pharmaceutical fine chemical manufacturing facility.  As a result of the above
factors, gross margin percentage in the third quarter of 1998 decreased to 21.6%
from 24.5% in 1997.

    Research and development expenses increased $41 thousand, or 4.5% to $1.0
million in the third quarter of 1998.  This increase was due mainly to the cost
of additional research chemists and pilot plant costs to support the new product
pipeline.

    Selling, general and administrative expenses increased $1.0 million or
50.9%, to $2.8 million in the three-month period ended September 30, 1998 from
$1.9 million last year. This increase is due primarily to additional expenses
associated with the Annan facility acquired in the fourth quarter of 1997.

    Interest expense was $1.1 million in the third quarter of 1998 compared to
interest income of $11 thousand in last year's third quarter.  This is a result
of higher borrowing levels resulting from the acquisition of the Annan facility
in the fourth quarter of 1997 and significant capital improvement projects in
1998.

    The Company announced in July 1998, a restructuring including management
changes and the transition to a product management structure.  The Company
expects to record a total pre-tax restructuring charge of $4.9 million in
fiscal-year 1998 related to severance and other costs of this restructuring, 
of which $2.8 million has been recognized for expenses incurred in the quarter
ended September 30, 1998 with the balance expected to be recognized in the
fourth quarter. Third quarter 1998 restructuring expenses include severance
costs related to management changes made to implement the product management
structure. As of September 30, 1998, approximately $1.8 million of this
restructuring charge is reflected in accrued expenses on the balance sheet.

    The benefit for income taxes was $0.4 million in the three-month period
ended September 30, 1998, versus a $0.6 million provision for income taxes in
the comparable prior-year period. This represents an effective rate of 32.1% in
1998 compared to an effective rate of 27.6% in the same period in 1997. The
higher effective tax rate in 1998 is the result of profitability expectations
for 1998.

    As a result of the factors described above, the Company reported a net loss
of $0.7 million in the third quarter of 1998 compared to net income of $1.6
million for the comparable prior-year period.

Nine-month period ended September 30, 1997 and 1998

    Total revenues increased $15.7 million, or 22.9% to $83.9 million in the
first nine months of 1998, from $68.3 million in the comparable period in 1997,
as new products came on stream and shipments under the Glaxo Wellcome supply
contract expanded, partly offset by the unfavorable effect on revenues from the
sale of the acetaminophen business which contributed $17.0 million in revenues
to the first nine months of 1997.

    Cost of goods sold increased $14.5 million, or 28.4% to $65.6 million in the
nine-month period ended September 30, 1998 from $51.1 million in last year's
first nine months.  This increase is due to the higher volume of new product
sales 

                                       9
<PAGE>
 
partly offset by lower acetaminophen sales, expenses associated with new product
introductions, and the under-utilization of the Annan facility acquired in the
fourth quarter of 1997 during its re-conditioning into a general-purpose
pharmaceutical fine chemical manufacturing facility. The Company also
experienced production interruptions for one product during the second quarter
that resulted in unfavorable manufacturing variances. The production
difficulties for this product were resolved and full-scale production resumed in
mid-July 1998. As a result of the above factors, gross margin percentage in the
first nine months of 1998 decreased to 21.8% from 25.2% in 1997.

    Research and development expenses increased $0.2 million, or 8.2% to $3.2
million in the first nine months of 1998.  This increase was due mainly to the
cost of additional research chemists and pilot plant costs to support the new
product pipeline.

    Selling, general and administrative expenses increased $2.7 million or
41.4%, to $9.1 million in the nine-month period ended September 30, 1998 from
$6.5 million last year. This increase is due primarily to additional expenses
associated with the Annan facility acquired in the fourth quarter of 1997 and
expenses incurred related to the search for a Chief Operating Officer.

    The Company expects to record a total pre-tax restructuring charge of $4.9
million in fiscal-year 1998 associated with the restructuring announced in July
1998, of which $2.8 million has been recognized for expenses incurred in the
third quarter with the balance expected to be recognized in the fourth quarter.
Other expenses were $3.0 million in the nine-month period ended September 30,
1998 versus $6.6 million in the comparable prior-year period. The 1998
restructuring charge and other expenses includes $2.8 million incurred in the
third quarter 1998 for the aforementioned restructuring and $0.2 million of
other costs incurred in the second quarter 1998 by a special committee of the
Company's board of directors whose work culminated in the restructuring
announced in July 1998. The 1997 restructuring charge represented expenses
associated with the disposition of the acetaminophen business.

    Interest expense was $3.9 million in the first nine months of 1998 compared
to $0.1 million last year. This is a result of higher borrowing levels resulting
from the acquisition of the Annan facility in the fourth quarter of 1997 and
significant capital improvement projects in 1998.

    The benefit for income taxes was $0.6 million in the nine-month period ended
September 30, 1998, versus a $0.1 million provision for income taxes in the
comparable prior-year period.  This represents an effective rate of 33.0% in
1998 compared to an effective rate of 47.2% in the same period in 1997.

    As a result of the factors described above, the Company reported net loss of
$1.2 million in the first nine months of 1998 compared to net income of $0.1
million for the comparable prior-year period.

LIQUIDITY AND CAPITAL RESOURCES

    Cash provided from operations for the first nine months of 1998 of $14.0
million is $14.2 million higher than the $0.2 million used in the same period in
1997 and reflects a $1.1 million reduction in the Company's net investment in
operating assets.

    Net cash used in investing activities in the first nine months of 1998 was
$28.3 million compared to $2.7 million in the same period of 1997.  Capital
spending in 1998 includes expenditures for plant maintenance, alteration of
equipment at Dudley to accommodate new products, and modification of the Annan
facility. The majority of these expenditures are to accommodate newly contracted
products at Dudley and Annan, and to convert the Annan facility to a multi-
product pharmaceutical fine chemical manufacturing facility.

    Net cash provided from financing activities for the first nine months of
1998 of $13.9 million is the result of $13.4 million in borrowings under the
company's revolving credit facility and $0.5 million in proceeds received from
the exercise of stock options.

                                       10
<PAGE>
 
    As of September 30, 1998, the Company was not in compliance with certain
financial covenants of its revolving-credit and term-loan credit facilities (the
"Facilities Agreement").  The lenders have permanently waived these defaults and
the Company has agreed to certain modifications to the Facilities Agreement.
After taking into consideration the waivers and modifications to the Facilities
Agreement, the Company is in compliance with all of the terms of the Facilities
Agreement at September 30, 1998. Under the Company's current business plan, 
management expects the Company will be unable to satisfy certain financial 
covenants in the future, however, the Company has received an unconditional 
letter from its lenders expressing their intent to continue their support of the
Company and to negotiate in good faith, further modifications to the Facilities
Agreement as necessary.


    The Company expects to satisfy its cash requirements, including the
requirements of its subsidiaries, through internally generated cash and
borrowings.

YEAR 2000 DISCLOSURE

    The Company has dedicated internal resources to identify and resolve "year
2000" compliance issues with respect to computer systems and applications
utilized by the Company.  The Company has also engaged external resources,
including hiring an independent consulting firm, and will purchase necessary
computer software and upgrades to become year 2000 compliant. The Company will 
develop comprehensive testing procedures once necessary software and equipment
have been installed to validate year 2000 compliance. The Company is
implementing a year 2000 compliant management information system at its Annan
facility in connection with its business plans for this location. The Company's
plan is to implement these systems at the Company's other locations, including
the Dudley facility, in 1999. The Company expects to spend approximately $3.0
million on systems and equipment which are year 2000 compliant.

     The Company believes that the systems at two of the three production
facilities at Annan are year 2000 compliant.  At present, the Company is not
utilizing the third production facility at Annan.  In the event that the Company
commences operations at this third facility, it expects to spend $1.0 million
upgrading the facility's computer systems and applications and will expense 
these costs in accordance with current accounting guidance.

     No assurance can be given that the year 2000 compliance issues will be
resolved without any future disruption or that the Company will not incur
significant additional expense in resolving the issue.  In addition, the failure
of certain of the Company's significant suppliers and customers to address the
year 2000 compliance issues could have a material adverse effect on the company.

     Contingency plans have been addressed for all major computer systems and
applications, and they include manual capability of certain business areas if
necessary, and the controlled shutdown and start up of the manufacturing plant
for a minimum period of days during the date change.  The approach, methodology,
plans, and contingencies for internal processes have been reviewed by our 
independent computer consultant and are subject to further development and 
testing. With regards to external factors such as supply of raw materials,
access to funds and potential utility disruption, the Company's contingency
plans are at a preliminary stage and require further development.

FOREIGN CURRENCY

    The Company currently expects that sales of its products outside the United
States will continue to be a substantial percentage of its net sales. The
Company currently intends to hedge its foreign exchange exposure to a certain
extent by entering into forward contracts with banks to the extent that the
timing of the currency flows can reasonably be anticipated.  The Company
believes it has a natural currency hedge because its operating expenses tend to
be denominated in matched currencies.  Also the Company has partly offset
foreign currency-denominated assets with foreign currency-denominated
liabilities.

    Financial results of the Company could be adversely or beneficially affected
by fluctuations in foreign exchange rates. Fluctuations in the value of foreign
currencies will affect the U. S. dollar value of the Company's net investment in
its foreign subsidiaries, with related effects included in a separate component
of stockholders' equity titled Cumulative Translation Adjustments. Operating
results of foreign subsidiaries are translated into U. S. dollars at average
monthly exchange rates and balance sheet amounts are translated at period-end
exchange rates.  In addition, the U. S. dollar value of transactions based in
foreign currency also fluctuates with exchange rates. The Company expects that
the largest foreign currency exposure will result from activity in Great Britain
pounds sterling, German marks and Dutch guilders.

                                       11
<PAGE>
 
PART II - OTHER INFORMATION


ITEM 4.    Submission of Matters to a vote of Security Holders.
           ----------------------------------------------------

           -NONE-

ITEM 5.    Other Information
           -----------------

           -NONE-

ITEM 6.    Exhibits and Reports on Form 8-K
           --------------------------------

           (a)  Exhibits. The exhibits listed on the accompanying Exhibit Index
                are filed as part of this Quarterly Report on Form 10-Q.

           (b)  Current Reports on Form 8-K:
                    On September 1, 1998, the Company filed a Current Report on
                    Form 8-K reporting management changes and restructuring.

SIGNATURE


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                               CHIREX INC.



Date:  November 16, 1998                        By:  /s/ Jon E. Tropsa
                                                     -----------------

                                                     Jon E. Tropsa
                                                     Vice President, Finance

                                       12
<PAGE>
 
EXHIBIT INDEX


Exhibit Number            Description
- --------------            -----------

      4.5                 Second Amendment dated 16 November 1998
                          to Facilities Agreement dated 30 October 1997

      27                  Financial Data Schedule.

                                       13

<PAGE>
 
                    SECOND AMENDMENT DATED . NOVEMBER 1998

                                      TO

                  FACILITIES AGREEMENT DATED 30 OCTOBER 1997


THIS SECOND AMENDMENT (this "AMENDMENT") is dated . November 1998 and entered
into by and among:

(1) CHIREX (HOLDINGS) LIMITED, a limited company organised under the laws of 
    England with registered number 3080257 with its registered office at Dudley,
    Cramlington, Northumberland NE23 7QG (the "BORROWER")

(2) BANKERS TRUST INTERNATIONAL PLC and MIDLAND BANK PLC, as Joint Arrangers 
    ("JOINT ARRANGERS")

(3) BANKERS TRUST COMPANY, as Agent ("AGENT")

(4) BANKERS TRUST COMPANY, as Security Agent ("SECURITY AGENT")
  
(5) the Lenders referred to in the Facilities Agreement, as defined below (the
    "LENDERS"); and

(6) for purposes of Section 5 hereof, CHIREX INC., a corporation organised under
    the laws of the State of Delaware with its principal office at 300 Atlantic
    Street, Suite 402, Stamford, CT 06901, U.S.A., CHIREX (DUDLEY) LIMITED, a
    limited company organised under the laws of England with registered number
    857670 with its registered office at Dudley, Cramlington, Northumberland
    NE23 7QG, and CHIREX (ANNAN) LIMITED, a limited company organised under the
    laws of England with registered number 3417229 with its registered office at
    Dudley, Cramlington, Northumberland NE23 7QG, each as Guarantors
    ("GUARANTORS").



                                    RECITALS


    WHEREAS, the parties listed above, among others, are parties to that certain
    GBP 62,000,000 Facilities Agreement dated 30 October 1997 as amended by the
    First Amendment dated 30 July, 1998 (as such Facilities Agreement may be
    amended, novated or supplemented from time to time, the "FACILITIES
    AGREEMENT"). Capitalised terms used in this Amendment without definition
    shall have the same meanings herein as set forth in the Facilities
    Agreement;

    WHEREAS, the Borrower has requested that the Lenders amend certain
    provisions of the Facilities Agreement;

    NOW THEREFORE, in consideration of the premises and the agreements,
    provisions and covenants contained herein and the receipt of (Pounds)1, the
    adequacy of which is hereby acknowledged, the parties hereto agree as
    follows:

- -1
<PAGE>
 
1   AMENDMENTS

    1.1 Clause 1.1 of the Facilities Agreement is hereby amended by adding the
        following proviso at the end of the definition of "Margin" therein:

    "Provided that, notwithstanding the above, the Margin shall be 2.00% from
    the Second Amendment Effective Date until 31st December 1999, subject to the
    Agent and NatWest, acting on the instructions of the Majority Banks
    reviewing the level of the Margin (with a view to maintaining the Margin or
    reducing it but without prejudice to the Lender's rights under the
    Facilities Agreement) on a quarterly basis prior to 31 December 1999 and
    subject to this proviso having no further force and effect after 31 December
    1999".

    1.2 Clause 13.4.1(b) of the Facilities Agreement is hereby amended by
        deleting the clause in its entirety and substituting the following
        therefor:

        "(b)    MINIMUM INTEREST COVERAGE RATIO
         ----                                   

                ChiRex Inc. shall maintain, as of the end of each Accounting
                Quarter to occur during the periods shown below, an Interest
                Coverage Ratio of not less than the minimum Interest Coverage
                Ratio shown below:

                ---------------------------------------------------------------
                PERIOD                            MINIMUM INTEREST COVERAGE
                                                          RATIO
                ===============================================================

                1 October 1998 to 31 December 1998          3.0:1
                Thereafter                                  3.5:1
                ---------------------------------------------------------------

    1.3 Clause 13.4.1(c) of the Facilities Agreement is hereby amended by the
        addition of the following paragraph (iii) at the end of the existing
        paragraph (ii):

        (iii)   when testing Total Debt for the purposes of testing the
                covenants in Clauses 13.4.1(a) and (b) of the Facilities
                Agreement, any sum standing to the credit of any account of any
                Obligor on any date of determination will be taken into account
                to reduce the calculation of the Financial Indebtedness of that
                Obligor, subject to the Borrower complying with the provisions
                of Clause 9.2 below.

2        REPRESENTATIONS AND WARRANTIES 

         Each of the Borrower and the Guarantors hereby represents and warrants
         to the Agent and the Lenders that:

         2.1    as of the date hereof, assuming that the amendments contained
                herein have been effected there exists no Event of Default or
                Potential Event of Default under the Facilities Agreement, and
                after giving effect to this Amendment, there will exist no Event
                of Default or Potential Event of Default under the Facilities
                Agreement;

         2.2    all representations and warranties contained in the Facilities
                Agreement and the other Finance Documents are true, correct and
                complete in all material respects on and as of the date hereof
                except to the extent such representations and warranties
                specifically relate to an earlier date, in which case they were
                true, correct and complete in all material respects on and as of
                such earlier date;

- -2
<PAGE>
 
       2.3      as of the date hereof, the Borrower has performed all agreements
                to be performed on its part as set forth in the Facilities
                Agreement;

       2.4      it is duly organised and validly existing under the laws of the
                jurisdiction of its organisation, and has all necessary power
                and authority to execute and deliver this Amendment and to
                consummate the transactions contemplated hereby;


       2.5      neither the execution and delivery of this Amendment, nor the
                consummation of the transactions contemplated hereby, violates
                (i) any law, regulation, decree or other legal restriction
                applicable to it, (ii) its charter, by-laws or other
                constitutional documents or (iii) any instrument or agreement to
                which it or any of its assets is subject or by which it is
                bound;

       2.6      there is no legal requirement of any governmental authority
                (including any requirement to make any declaration, filing or
                registration or to obtain any consent, approval, license or
                order) which is necessary to be met by it in connection with its
                execution, delivery or performance of this Amendment; and

       2.7      this Amendment has been duly authorised, executed and delivered
                on its behalf and this Amendment, the Facilities Agreement, as
                amended by this Amendment, and the other Finance Documents to
                which it is a party constitute its legal, valid and binding
                obligation, enforceable against it in accordance with their
                terms, except as limited by the Reservations.

3      COUNTERPARTS; EFFECTIVENESS

       3.1      This Amendment may be executed in any number of counterparts and
                by different parties hereto in separate counterparts, each of
                which when so executed and delivered shall be deemed an
                original, but all such counterparts together shall constitute
                but one and the same instrument; signature pages may be detached
                from multiple separate counterparts and attached to a single
                counterpart so that all signature pages are physically attached
                to the same document.

       3.2      This Amendment shall become effective on the date (the "SECOND
                AMENDMENT EFFECTIVE DATE") when the conditions have been
                satisfied that (i) each of the Borrower, the Guarantors, the
                Agent, the Security Agent and the Lenders shall have signed a
                counterpart hereof (whether the same or different counterparts)
                and shall have delivered (including by way of facsimile
                transmission) the same to the Agent, (ii) the Borrower shall
                have delivered to the Agent favourable opinions of Cravath,
                Swaine & Moore, U.S. legal advisers to the ChiRex Group, and
                Dibb Lupton Alsop, English legal advisers to the ChiRex Group,
                in each case addressed to the Agent and the Lenders, dated the
                effective date of this Amendment and in form and substance
                satisfactory to the Agent.

       3.3      On and after the Second Amendment Effective Date, each reference
                in the Facilities Agreement to "this Agreement", "hereunder",
                "hereof", "herein" or words of like import referring to the
                Facilities Agreement, and each reference in the other Finance
                Documents to the "Facilities Agreement", "thereunder", "thereof"
                or words of like import referring to the Facilities Agreement
                shall mean and be a reference to the Facilities Agreement as
                amended by the first Amendment Agreement, and by this Amendment.

       3.4      This Amendment is limited as specified and shall not constitute
                a modification, acceptance or waiver of any other provision of
                the Facilities Agreement, any provision of 

- -3
<PAGE>
 
                any other Finance Document or any right, power or remedy of the
                Agent or any Lender under the Facilities Agreement shall remain
                in full force and effect and is hereby ratified and confirmed.

       3.5      Clause headings in this Amendment are included herein for
                convenience of reference only and shall not constitute a part of
                this Amendment for any other purposes or be given any
                substantive effect.

4      GOVERNING LAW; JURISDICTION

       4.1      This Amendment and the rights and obligations of the parties
                hereunder shall be governed by, and shall be construed and
                enforced in accordance with, the laws of England.

       4.2      Each Guarantor and Borrower hereby ratifies and confirms the
                application of the provisions of Clause 30 of the Facilities
                Agreement to this Amendment.

5      ACKNOWLEDGEMENT AND CONSENT BY GUARANTORS

       Each of the Guarantors hereby acknowledges that it has read this
       Amendment and consents to the terms thereof and further hereby confirms
       and agrees that, notwithstanding the effectiveness of this Amendment, the
       obligations of such Guarantor under its respective Guarantee shall not be
       impaired or affected and such Guarantee is, and shall continue to be, in
       full force and effect and is hereby confirmed and ratified in all
       respects.

6      WAIVER

       6.1 PERMANENT WAIVER

           6.1.1   This waiver contained in this Clause 6 shall supersede the
                   Limited Waiver dated 23 October 1998, by which the Lenders
                   waived compliance with certain provisions of the Facilities
                   Agreement during the period beginning 23 October 1998 and
                   ending on 8 December 1998 (the "OCTOBER LIMITED WAIVER") in
                   its entirety and the October Limited Waiver shall have no
                   further force or effect from and after the Second Amendment
                   Effective Date.

           6.1.2   Subject to the other terms and conditions set forth herein
                   and in reliance on the representations and warranties of the
                   Borrower herein contained, Lenders hereby waive, with effect
                   solely from the Second Amendment Effective Date and in
                   perpetuity thereafter, any Event of Default under Clause
                   14.1.2 of the Facilities Agreement to the extent, and only
                   the extent, resulting from ChiRex Inc.'s failure to maintain
                   (a) a Total Debt/EBITDA Ratio for the respective periods from
                   1 July 1998 to 30 September 1998 and 1 August 1998 to 31
                   October 1998 not exceeding 4.75:1 in each case; and (b) an
                   Interest Coverage Ratio as of the end of the Accounting
                   Quarter ending 30 September 1998 not less than 3.0:1.

           6.1.3   The Borrower hereby agrees (i) to deliver the consolidated
                   monthly management accounts for each successive fiscal month
                   ending during the period from the Second Amendment Effective
                   Date until 31 December 1999 (the "MONITORING PERIOD") and
                   referred to in Clause 13.3.4 (c) (including the information
                   required by the proviso to Clause 13.3.4 as it relates to
                   paragraph (c) of such clause) of the Facilities Agreement,
                   together with the certificate 

- -4
<PAGE>
 
                   required in respect thereof under Clause 13.3.5 of the
                   Facilities Agreement, not later than the 21st day of the
                   following month, and (ii) during each successive week
                   beginning during the Monitoring Period, a forecast of
                   consolidated cash flow for the ChiRex Group to include for
                   weeks 1 and 2 an analysis of all material receipts and
                   payments with appropriate commentary as to the timing and
                   nature of such receipts and payments and an analysis of the
                   timing of and likely amounts of Drawdowns to be made and for
                   each of the succeeding 3 weeks in form and substance
                   satisfactory to the Agent and National Westminster Bank plc
                   ("NATWEST"). Time is of the essence in the Borrower's
                   obligations under this Clause 6.1.3 and any failure by the
                   Borrower to comply with this Clause 6.1.3 in a full and
                   timely basis shall be an Event of Default under the
                   Facilities Agreement.

           6.1.4   Subject to the other terms and conditions set forth herein 
                   and in reliance on the representation and warranties of the
                   Borrower herein contained, the Lenders hereby agree with
                   effect solely from the Second Amendment Effective Date that
                   the obligation of the Borrower under Clause 6.1.1 of the
                   Facilities Agreement to make a repayment of
                   (Pounds)4,444,444.44 on the 31 December 1998 Repayment Date
                   (the "DECEMBER AMORTISATION") in respect of the Tranche A
                   Term Loan shall be deferred to the date which is eighteen
                   months after the Second Amendment Effective Date (the
                   "REVISED PAYMENT DATE") subject to the provisions of Clause
                   9.1 below, and the operation of the cash sweep mechanism.

6.2        LIMITATION OF WAIVER

           Without limiting the generality of the provisions of Clauses 22 or 26
           of the Facilities Agreement, the waiver set forth above shall be
           limited precisely as written, and nothing in this Clause 6 shall be
           deemed to:

           6.2.1   constitute a waiver of any other term, provision or condition
                   of the Facilities Agreement or any other instrument or
                   agreement referred to therein or otherwise; or

           6.2.2   prejudice any right or remedy that Agent or any Lender may
                   now have or may have in the future under or in connection
                   with the Facilities Agreement or any other instrument or
                   agreement referred to therein.

                   Except as expressly set forth therein, the terms, provisions
                   and conditions of the Facilities Agreement and the other
                   Finance Documents shall remain in full force and effect and
                   in all other respects are hereby ratified and confirmed.

6.3        FINANCE PARTY EXPENSES; CERTAIN AGENCY MATTERS

           6.3.1   Without limitation to Clauses 11 (Fees, Expenses and Stamp
                   Duties) and 27 (Indemnities) of the Facilities Agreement but
                   without duplication, the Borrower hereby agrees that it will
                   on demand pay and reimburse, on the basis of a full
                   indemnity, all reasonable costs and expenses (including
                   reasonable accounting, legal and engineering consultancy fees
                   and expenses, recordation fees and other out-of-pocket
                   expenses, including for the avoidance of doubt the
                   professional fees of Ernst & Young and Linklaters & Paines,
                   and any VAT or
- -5
<PAGE>
 
                   other similar Tax on any of the foregoing) incurred by the
                   Agent, the Security Agent or NatWest in connection with:

           (a)     this Amendment and any subsequent variation, recordation,
                   amendment, supplement, restatement, waiver, consent or
                   suspension of rights (or any proposal for any of the same or
                   negotiations in connection with the same) relating to any of
                   the Finance Documents (and documents, matters or things
                   referred to therein); and

           (b)     the investigation of the prospects, financial condition,
                   business, assets and/or revenues of the Borrower, its
                   subsidiaries and its affiliates.

           6.3.2   Each Lender reaffirms the appointment of NatWest to act as
                   its representative in assisting the Agent and otherwise in
                   investigating the prospects, financial condition, business,
                   assets and revenues of the Borrower, its subsidiaries and its
                   affiliates, and agrees that NatWest shall be entitled in such
                   capacity to the benefits of Clause 16 (including without
                   limitation the indemnities therein and exculpatory provisions
                   thereof) of the Facilities Agreement as if references to the
                   Agent therein were also to NatWest, mutatis mutandis.

7          KEY PERFORMANCE INDICATORS

           The parties to this Amendment hereby agree as follows:

           7.1 Ernst & Young, in consultation with the Borrower will establish
               criteria ("KEY PERFORMANCE INDICATORS") within 7 days from the
               Second Amendment Effective Date, which the Agent will use to
               monitor the performance of the Borrower in meeting its
               obligations under the Facilities Agreement.

           7.2 For the purposes of this sub-clause the Agent and NatWest act at
               all times on the instructions of the Majority Lenders and after
               receiving the advice of Ernst & Young. If the Agent and NatWest
               determine, save in the case of manifest error, that the Borrower
               has breached Key Performance Indicators, and in the reasonable
               opinion of the Agent and NatWest, the breaches of those Key
               Performance Indicators indicate that the Borrower is likely to
               breach the terms and conditions of the Facilities Agreement, in
               any material way then the Agent and NatWest, will request that
               the Borrower provide an explanation as to either why it believes
               the terms and conditions of the Facilities Agreement will not be
               materially breached and/or or what steps the Borrower is taking
               to avoid such material breach and the Agent and NatWest will
               agree to consider any such explanation in good faith but if the
               Agent and NatWest are not satisfied with such explanation or no
               such explanation is provided within a reasonable period of being
               requested, the Agent and NatWest may take such action as they
               think fit to enforce their rights under the Facilities Agreement.

           7.3 No amendment will be made to the Key Performance Indicators
               except as agreed by NatWest and the Agent, acting on the
               instructions of the Majority Banks.

8          FEES

           In consideration of the amendments to the Facilities Agreement made
           pursuant to Clause 1 above and the waiver and modification agreed by
           the Lenders pursuant to Clauses 6.1.2 and 

- -6
<PAGE>
 
           6.1.4 above, the Borrower agrees to pay to the Agent for the account
           of each Lender, the following (together the "SECOND AMENDMENT FEES"):

           8.1 an amendment fee of (Pounds)810,000 to be paid on 30 June 1999;
               and

           8.2 an additional monitoring fee of (Pounds)240,000 in total;

           the first payment of (Pounds)120,000 to be due on the Second
           Amendment Effective Date but payment to be deferred until the earlier
           of (i) the date upon which a restructuring or refinancing as
           described in Clause 9.3 below is effected by the Borrower in which
           case the second payment of (Pounds)120,000 shall never become payable
           or (ii) 31 March 1999;

           and the second payment of (Pounds)120,000 to be due on 1 April 1999
           but payment to be deferred until the earlier of (i) the date upon
           which a restructuring or refinancing as described in Clause 9.3 below
           is effected by the Borrower or (ii) 30 June 1999;

           with each payment of (Pounds)120,000 being apportioned as follows:
           and


                        APPOINTMENT OF MONITORING FEE PER QUARTER

           (Pounds) 30,000                    to The Agent
                                              
           (Pounds) 30,000                    to NatWest
                                              
           (Pounds) 60,000                    ((Pounds)6,000 to each Lender)
                                              
           (Pounds)120,000                    TOTAL

           8.3  the fees payable pursuant to Clause 9.4 below.

                Notwithstanding the above, the Borrower hereby confirms that the
                Fees Letter from the Agent to the Borrower dated 23 October 1998
                (the "WAIVER FEES LETTER"), remains in full force and effect,
                notwithstanding the supersession of the October Limited Waiver
                by Clause 6 of this Amendment, except that for the purposes of
                the Waiver Fees Letter and from the Second Amendment Effective
                Date, the references to

                   (i)     "Limited Waiver" therein shall refer to this
                           Amendment and

                  (ii)     the Facility Agreement dated 30 October 1997 as
                           amended by the First Amendment dated 30 July 1998
                           shall refer to the Facilities Agreement as further
                           amended by this Amendment.

9          CASH SWEEP AND UNDERTAKINGS

           9.1 The Borrower undertakes

                   (i)     to put into effect by 1 January 1999 a cash sweep
                           mechanism (on terms to be agreed between the Borrower
                           and Ernst & Young within 7 days of the Second
                           Amendment Effective Date which are satisfactory to
                           NatWest and the Agent acting on the instructions of
                           the Majority Lenders) to the intent that any cash
                           generated as a result of such mechanism and received
                           by the Agent shall be applied by the Agent 

- -7
<PAGE>
 
                           against the December Amortisation prior to the
                           Revised Payment Date; and

                  (ii)     to repay in full the December Amortisation, including
                           all principal, interest and any other sums then due
                           or owing in respect of the December Amortisation
                           whether by cash sweep mechanism or otherwise, by the
                           Revised Payment Date; and

                 (iii)     to pay any sums due owing or incurred pursuant to
                           this agreement, including but not limited to those
                           sums becoming due under Clauses 6.3 and 8 above, on
                           the due date for payment.

           9.2 If on a Repayment Date relating to repayment of Advances under
               the Tranche B Multicurrency Revolving Facility, which is also a
               date of determination for the purposes of calculating Total Debt
               in accordance with the financial covenants at Clauses 13.4.1(a)
               and (b), there are sums standing to the credit of the Borrower's
               account which are taken into account in reducing the Borrower's
               Financial Indebtedness as part of the testing of Total Debt but
               which have not been paid to the Agent on that Repayment Date, the
               Borrower undertakes to pay such sums to the Agent, on the next
               Business Day following the relevant Repayment Date.

          9.3  The Borrower undertakes that by 31 December 1999 it will use its
               reasonable endeavours to either:

               9.3.1  enter into an agreement providing for the effective
                      restructuring of the Facilities on terms acceptable to
                      NatWest and the Agent acting on the instructions of the
                      Majority Banks; or
   
               9.3.2  refinance all sums outstanding pursuant to the Facilities
                      (including any sums, costs, expenses and fees payable
                      pursuant to the Facilities Agreement in particular but not
                      limited to the Second Amendment Fees and fees payable
                      under the Waiver Fees Letter);

          9.4  Furthermore, in any event (i) if such restructuring or
               refinancing has not been effected by the Borrower by 30 June
               1999, the Borrower shall pay a further fee of (Pounds)250,000 to
               the Agent for the account of each Lender such sum to become due
               and immediately payable on 30 September 1999 and (ii) if such
               restructuring or refinancing has not been effected by the
               Borrower by 30 September 1999, the Borrower shall pay a further
               fee of (Pounds)250,000 to the Agent for the account of each
               Lender such sum to become due and immediately payable on 31
               December 1999 and (iii) if such restructuring or refinancing has
               not been effected by the Borrower by 31 December 1999 the
               Borrower agrees that it will discuss with the Agent and NatWest
               acting on the instructions of the Majority Lenders the level of
               further fees payable thereafter.

          9.5  Any failure by the Borrower to fulfil its undertakings under
               Clauses 9.1, 9.2 and 9.4 (i) and (ii) above (including
               undertakings to make payments) in full and at or by the times
               indicated above shall constitute an Event of Default.

10        SECURITY ISSUES

          Each of the Borrower and the Guarantors undertake that within 21 days
          of the Second Amendment Effective Date:

- -8
<PAGE>
 
          10.1  they will execute an agreement subordinating all indebtedness
                between companies forming part of the ChiRex Group to the sums
                owing pursuant to the Facilities Agreement; and
 
          10.2  (unless they are able to satisfy the Agent and NatWest acting
                reasonably on the instructions of the Majority Banks that there
                are valid legal and/or commercial reasons for not doing so; the
                Agent and NatWest to notify the Borrower and the Guarantors of
                the decision in writing) they will procure that ChiRex America
                Inc. and ChiRex Technology Center Inc. become Guarantors
                pursuant to the Facilities Agreement and that ChiRex America
                Inc. will provide security in respect of any Intellectual
                Property owned by it, in form and substance acceptable to the
                Security Trustee and NatWest; and

          10.3  they will procure that the relevant companies forms 403a are
                filed at Companies House in relation to the following charges
                granted in favour of Midland Bank plc by the Borrower:

                ---------------------------------------------------------------
                DATE OF CHARGE                         TYPE OF CHARGE
                ===============================================================
                10/8/95                                Fixed and Floating Charge

                30/11/95                               Pledge Agreement over 
                                                       Share Capital in Alice
                                                       Dudley Limited ("Dudley")
                ---------------------------------------------------------------

          10.4  they will procure that the Articles of Association of ChiRex
                (Dudley) Limited and ChiRex (Annan) Limited will be amended to
                remove the provision that grants their Directors an absolute
                discretion to refuse to register transfers of shares.

          10.5  Any failure by the Borrower and the Guarantors to fulfil their
                undertakings under this Clause 10 in full and at or by the times
                indicated above shall constitute an Event of Default.

11        AGENTS APPLICATION OF FEES

          If any fees are paid to the Agent by the Borrower in accordance with
          Clauses 8 and 9.3 above, the Agent agrees to pay such sums as are for
          the account of each Lender to that Lender within 2 business days of
          receipt by the Agent of such fees.

          IN WITNESS WHEREOF, the parties hereto have caused this Amendment to
          be duly executed and delivered by their respective officers thereunto
          duly authorised as of the date first written above.


CHIREX (HOLDINGS) LIMITED, in its capacity as the Borrower


By: (s)

Print Name:

Title:

- -9
<PAGE>
 
CHIREX INC., in its capacity as a Guarantor


By: (s)

Print Name:

Title:

CHIREX (DUDLEY) LIMITED, in its capacity as a Guarantor


By: (s)

Print Name:

Title:

CHIREX (ANNAN) LIMITED, in its capacity as a Guarantor


By: (s)

Print Name:

Title:

BANKERS TRUST INTERNATIONAL PLC, in its capacity as a Joint Arranger


By: (s)

Print Name:

Title:

MIDLAND BANK PLC, in its capacity as a Joint Arranger and a Lender


By: (s)

Print Name:

Title:

- -10
<PAGE>
 
BANKERS TRUST COMPANY, in its capacities as a Lender, Agent and Security Agent


By: (s)

Print Name:

Title:

THE GOVERNOR AND COMPANY OF
BANK OF IRELAND, in its capacity as a Lender


By: (s)

Print Name:

Title:

BANQUE ET CAISSE D'EPARGNE DE L'ETAT, in its capacity as a Lender


By: (s)

Print Name:

Title:


By: (s)

Print Name:

Title:

DE NATIONALE INVESTERINGSBANK N.V., in its capacity as a Lender


By: (s)

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Title:


By: (s)

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Title:

- -11
<PAGE>
 
IKB DEUTSCHE INDUSTRIEBANK AG, in its capacity as a Lender


By: (s)

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Title:


By: (s)

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Title:


AIB CAPITAL MARKETS PLC, in its capacity as a Lender


By: (s)

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Title:


MITSUBISHI TRUST & BANKING CORPORATION, in its capacity as a Lender


By: (s)

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Title:


COMPAGNIE FINANCIERE DE CIC ET DE L'UNION EUROPEENNE, in its capacity as a 
Lender


By: (s)

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Title:

- -12
<PAGE>
 
By: (s)

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Title:


NATIONAL WESTMINSTER BANK PLC, in its capacity as a Lender


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- -13

<TABLE> <S> <C>

<PAGE>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY INFORMATION EXTRACTED FROM ChiRex Inc.'s third
quarter 1998 Form 10-Q AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH
Form 10-Q
</LEGEND>
<CIK> 0001005407
<NAME> CHIREX INC.
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               SEP-30-1998
<CASH>                                           5,172
<SECURITIES>                                         0
<RECEIVABLES>                                   22,098
<ALLOWANCES>                                         0
<INVENTORY>                                     31,112
<CURRENT-ASSETS>                                 5,170
<PP&E>                                         170,369
<DEPRECIATION>                                  25,559
<TOTAL-ASSETS>                                 237,785
<CURRENT-LIABILITIES>                           50,082
<BONDS>                                         78,389
                                0
                                          0
<COMMON>                                           118
<OTHER-SE>                                      93,457
<TOTAL-LIABILITY-AND-EQUITY>                   237,785
<SALES>                                         83,600
<TOTAL-REVENUES>                                83,927
<CGS>                                           65,624
<TOTAL-COSTS>                                   81,007
<OTHER-EXPENSES>                                   873
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                               3,883
<INCOME-PRETAX>                                 (1,836)
<INCOME-TAX>                                       605
<INCOME-CONTINUING>                             (1,231)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                    (1,231)
<EPS-PRIMARY>                                    (0.10)
<EPS-DILUTED>                                    (0.10)
        

</TABLE>


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