CHIREX INC
SC TO-T/A, 2000-08-16
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE TO
            Tender Offer Statement Under Section 14(d)(1) or 13(e)(1)
                     of the Securities Exchange Act of 1934

                                 Amendment No. 1

                                   CHIREX INC.
                            (Name of Subject Company)


                            COUSIN ACQUISITION, INC.
                                     RHODIA
                      (Names of Filing Persons (Offerors))

                     Common Stock, Par Value $.01 Per Share
           (Including the Associated Preferred Share Purchase Rights)
                                   170038 10 3
                         (Title of Class of Securities)

                      (CUSIP Number of Class of Securities)

                                 John P. Donahue
                                   Rhodia Inc.
                            259 Prospect Plains Road
                           Cranbury, New Jersey 08512
                              Tel.: (609) 860-4370
  (Name, Address and Telephone Number of Persons Authorized to Receive Notices
                 and Communications on Behalf of filing persons)

                                    Copy to:
                              Hubertus V. Sulkowski
                               Shearman & Sterling
                          114 avenue des Champs Elysees
                               75008 Paris, France
                               (33-1) 53-89-70-00

                            CALCULATION OF FILING FEE
================================================================================
        Transaction Valuation*                  Amount of Filing Fee**
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
             $557,738,844                             $111,547.80
================================================================================

*     Estimated for purposes of calculating the amount of the filing fee only.
      Calculated by multiplying $31.25, the per share tender offer price, by
      17,847,643, the sum of the (i) 15,263,977 currently outstanding shares of
      Common Stock sought in the Offer as of July 23, 2000, (ii) outstanding
      options with respect to 2,508,666 shares of Common Stock as of July 23,
      2000, and (iii) 75,000 shares of Common Stock that could be purchased
      under the Company's employee stock purchase plan, as of July 31, 2000.
**    Calculated as 1/50 of 1% of the transaction value.
|X|   Check the box if any part of the fee is offset as provided by Rule
      0-11(a)(2) and identify the filing with which the offsetting fee was
      previously paid. Identify the previous filing by registration statement
      number, or the Form or Schedule and the date of its filing.
      Amount Previously Paid: $ 111,547.80
      Form or Registration No.: Schedule TO
      Filing Party: Cousin Acquisition, Inc., Rhodia
      Date Filed:  August 4, 2000
      Check the box if the filing relates solely to preliminary communications
      made before the commencement of a tender offer.
      Check the appropriate boxes to designate any transactions to which the
      statement relates:
|X|   third-party tender offer subject to Rule 14d-1.
***   issuer tender offer subject to Rule 13e-4.
***   going-private transaction subject to Rule 13e-3.
***   amendment to Schedule 13D under Rule 13d-2.
      Check the following box if the filing is a final amendment reporting the
      results of the tender offer: ***
<PAGE>

     This Amendment No. 1 amends and supplements the Tender Offer Statement on
Schedule TO originally filed with the Securities and Exchange Commission (the
"Commission") on August 4, 2000 by Rhodia, a French corporation ("Parent") and
Cousin Acquisition, Inc., a Delaware corporation ("Purchaser") and an indirect
wholly owned subsidiary of Parent. The Schedule TO relates to the offer by
Purchaser to purchase all issued and outstanding shares of Common Stock, par
value $.01 per share (the "Common Shares"), together with the associated rights
to purchase preferred shares that are issued pursuant to the Rights Agreement
dated as of March 31, 1997 between ChiRex Inc. and The First National Bank of
Boston as Rights Agent (the "Rights" and, together with the Common Shares, the
"Shares"), of ChiRex Inc., a Delaware corporation (the "Company"), at a purchase
price of $31.25 per Share, net to the seller in cash, upon the terms and subject
to the conditions set forth in the Offer to Purchase dated August 4, 2000 (the
"Offer to Purchase") and in the related Letter of Transmittal, which, together
with any amendments or supplements thereto, collectively constitute the "Offer".
Copies of the Offer to Purchase and the related Letter of Transmittal are filed
with the Schedule TO as Exhibits (a)(1) and (a)(2), respectively. Capitalized
terms used and not defined herein shall have the meanings assigned to such terms
in the Offer to Purchase or in the Schedule TO.



Item 11.  Additional Information

          Item 11 of the Schedule TO , which incorporates by reference the
     information contained in the Offer to Purchase, is hereby amended and
     supplemented to include the following information:

     On August 15, 2000, Parent received early termination of the waiting period
     with respect to the Offer and the Merger under the HSR Act.

     On August 16, 2000, Parent issued a press release announcing the early
     termination of the waiting period with respect to the Offer and the Merger
     under the HSR Act, a copy of which is filed as Exhibit (a)(11) hereto and
     is incorporated herein by reference.

Item 12.  Material to Be Filed as Exhibits.

(a)(11)   Press Release Issued by Parent on August 16, 2000.
<PAGE>

After due inquiry and to the best of my knowledge and belief, I certify that the
information set forth in this statement is true, complete and correct.

Dated:  August 16, 2000

                                     COUSIN ACQUISITION, INC.


                                     By: /s/ John P. Donahue
                                     Name: John P. Donahue
                                     Title:  President, Secretary and Treasurer
<PAGE>

          After due inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:  August 16, 2000

                                               RHODIA


                                   By: /s/ Michel Marien
                                       Name: Michel Marien
                                       Title: President of the Life Science
                                       Chemicals Enterprise
<PAGE>

                                  EXHIBIT INDEX

Exhibit
No.

*(a)(1)        Offer to Purchase dated August 4, 2000.

*(a)(2)        Form of Letter of Transmittal.

*(a)(3)        Form of Notice of Guaranteed Delivery.

*(a)(4)        Form of Letter to Brokers, Dealers, Commercial Banks, Trust
               Companies and Other Nominees.

*(a)(5)        Form of Letter to Clients for use by Brokers, Dealers,
               Commercial Banks, Trust Companies and Other Nominees.

*(a)(6)        Form of Guidelines for Certification of Taxpayer Identification
               Number on Substitute Form W-9.

*(a)(7)        Summary Advertisement as published in The Wall Street Journal on
               August 4, 2000.

*(a)(8)        Joint Press Release issued by Parent and the Company on July 24,
               2000.

*(a)(9)        Transcript of Analyst Conference Call held  on July 24, 2000,
               and made available for replay on July 25, 2000.

*(a)(10)       Press Release Issued by Parent on August 4, 2000.

(a)(11)        Press Release issued by Parent on August 16, 2000.

*(d)(1)        Agreement and Plan of Merger, dated as of July 24, 2000, among
               Parent, Purchaser and the Company.

*(d)(2)        Confidentiality Agreement, dated May 26, 2000, between Parent
               and the Company.

*(d)(3)        Confidentiality Agreement, dated June 27, 2000, between Parent
               and the Company.

*(d)(4)        Consulting Agreement, dated as of the 24th day of July, 2000,
               among the Company, Michael A. Griffith and Parent.

----------------------------
*        Previously filed.
<PAGE>

*(d)(5)        Consulting Agreement, dated as of the 24th day of July, 2000,
               among the Company, Francis Jackson Wright and Parent.

*(d)(6)        Extension to Consulting Agreement, dated as of the 21st day of
               July, 2000, between the Company and K. Barry Sharpless.

*(d)(7)        Employment Agreement, dated as of the 24th day of July, 2000,
               among the Company, Ian D. Shott and Parent.

*(d)(8)        Employment Agreement, dated as of the 24th day of July, 2000,
               among the Company, Bruce P. Shutts and Parent.

* (d)(9)       Employment Agreement, dated as of the 24th day of July, 2000,
               among the Company, Stuart E. Needleman and Parent.

*(d)(10)       Letter agreement re: grants of stock appreciation rights, dated
               as of July 21, 2000, between Parent and K. Barry Sharpless.

*(x)(24)       Power of attorney from Mr. Bravard to Mr. Marien.


----------------------------
*        Previously filed.


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