BIO-SPHERE TECHNOLOGY INC
4, 1999-02-10
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[  ] Check this box if no longer subject of Section 16. Form 4 or Form 5
     obligations may continue. See Instruction 1(b).

================================================================================
1. Name and Address of Reporting Person*

                          Bio-Sphere Technology, Inc.
- --------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)

                        1325 Airmotive Way, Suite 125
- --------------------------------------------------------------------------------
                                    (Street)

   Reno,                              NV                 89502
- --------------------------------------------------------------------------------
   (City)                           (State)              (Zip)


================================================================================
2. Issuer Name and Ticker or Trading Symbol

                           Harvard Scientific Corp.   HVSF

================================================================================
3. IRS or Social Security Number of Reporting Person (Voluntary)


================================================================================
4. Statement for Month/Year

                     01/99
================================================================================
5. If Amendment, Date of Original (Month/Year)


================================================================================
6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   [   ]   Director                             [ x ]   10% Owner
   [   ]   Officer (give title below)           [   ]   Other (specify below)



================================================================================
7. Individual or Joint/Group Filing (Check applicable line)

   [x] Form filed by one Reporting Person 
   [ ] Form filed by more than one Reporting Person

<TABLE>

================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================

<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                   <C>            <C>      <C>    <C>         <C>    <C>      <C>            <C>       <C>
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/04/99       S               2,000       D      $1.3750                 D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/05/99       S               2,000       D      $1.5000                 D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/06/99       S               1,000       D      $1.4375                 D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/06/99       S               1,000       D      $1.5000                 D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/07/99       S               1,000       D      $1.2500                 D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/07/99       S               1,000       D      $1.1875                 D
- ------------------------------------------------------------------------------------------------------------------------------------
      (see continuation sheet for additional sales)                                              547,250        D
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

====================================================================================================================================
                                                                          (Over)
</TABLE>
* If the Form is filed by more than one Reporting Person, see Instruction
4(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.          


                                   Page 1 of 3

<PAGE>

FORM 4 (continued)

 Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned

         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                          9.        10.
                                                                                                          Number    Owner-
                                                                                                          of        ship
                    2.                                                                                    Deriv-    of
                    Conver-                    5.                              7.                         ative     Deriv-   11.
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature
                    of                         Derivative    6.                of Underlying     8.       ities     Secur-   of
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner-
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------



====================================================================================================================================
</TABLE>
Explanation of Responses:


        /s/ Jackie R. See, President                            2/05/99
- ---------------------------------------------            -----------------------
      **Signature of Reporting Person                             Date


**     Intentional misstatements or omissions of facts constitute Federal
       Criminal Violations.

       See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedures.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.

                                   Page 2 of 3
                                                                 SEC 1474 (7-96)





<PAGE>
FORM 4 (Continued)

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

================================================================================
1. Name and Address of Reporting Person*

                           Bio-Sphere Technology, Inc.
- --------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)
                         1325 Airmotive Way, Suite 125
- --------------------------------------------------------------------------------
                                    (Street)
    Reno                              NV                 89502
- --------------------------------------------------------------------------------
   (City)                           (State)              (Zip)

================================================================================
2. Issuer Name and Ticker or Trading Symbol

                          Harvard Scientific Corp HVSF
================================================================================
4. Statement for Month/Year

                    01/99
================================================================================
<TABLE>
<CAPTION>

                                                                                                               6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                   <C>            <C>      <C>     <C>         <C>   <C>       <C>            <C>       <C>
Common Stock                          01/08/99       S                2,000       D     $1.1562                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/11/99       S                2,000       D     $1.1250                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/12/99       S                2,000       D     $1.1250                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/12/99       S                  500       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/13/99       S                2,000       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/14/99       S                2,000       D     $1.0937                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/15/99       S                2,000       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/15/99       S                  500       D     $1.0937                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/19/99       S                2,000       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/20/99       S                2,000       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/21/99       S                1,000       D     $1.0000                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/21/99       S                1,000       D     $1.0625                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/22/99       S                2,000       D     $0.9687                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/25/99       S                2,000       D     $0.9375                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/26/99       S                2,000       D     $0.9062                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/27/99       S                2,000       D     $0.9062                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/28/99       S                2,000       D     $0.9062                  D
- ------------------------------------------------------------------------------------------------------------------------------------
Common Stock                          01/29/99       S                2,000       D     $0.9062                  D
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                  547,250        D
- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>


                                   Page 3 of 3




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