HARVARD SCIENTIFIC CORP
4, 1998-09-10
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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<PAGE>

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[  ] Check this box if no longer subject of Section 16. Form 4 or Form 5
     obligations may continue. See Instruction 1(b).

================================================================================
1. Name and Address of Reporting Person*

See,                                Jackie              R.
- --------------------------------------------------------------------------------
   (Last)                           (First)             (Middle)

100 N. Arlington Ave., Suite 23P
- --------------------------------------------------------------------------------
                                    (Street)

Reno,                               NV                   89501
- --------------------------------------------------------------------------------
   (City)                           (State)              (Zip)


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2. Issuer Name and Ticker or Trading Symbol


Harvard Scientific Corp.    HVSF
================================================================================
3. IRS or Social Security Number of Reporting Person (Voluntary)


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4. Statement for Month/Year

8/98
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5. If Amendment, Date of Original (Month/Year)


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6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   [ X ]   Director                             [ X ]   10% Owner
   [   ]   Officer (give title below)           [   ]   Other (specify below)



================================================================================
7. Individual or Joint/Group Filing (Check applicable line)

   [ X ] Form filed by one Reporting Person
   [   ] Form filed by more than one Reporting Person



================================================================================
           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
- ------------------------------------------------------------------------------------------------------------------------------------
 <S>                                   <C>            <C>      <C>    <C>         <C>    <C>      <C>            <C>       <C>
 Common Stock                          8/27/98        S               1,000       D      $5.25                   I         (1)
- ------------------------------------------------------------------------------------------------------------------------------------
 Common Stock                          8/28/98        S               1,000       D      $5.00                   I         (1)
- ------------------------------------------------------------------------------------------------------------------------------------
 Common Stock                          8/31/98        S                 500       D      $4.625                  I         (1)
- ------------------------------------------------------------------------------------------------------------------------------------
 Common Stock                          8/31/98        S                 500       D      $4.50                   I         (1)
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                  1,902,389      D/I       (2)
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
====================================================================================================================================
</TABLE>
* If the Form is filed by more than one Reporting Person, see Instruction 
  4(b)(v).

Reminder: Report on a separate line for each class of securities beneficially
          owned directly or indirectly.

                                   Page 1 of 1


<PAGE>


FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                          9.        10.    
                                                                                                          Number    Owner- 
                                                                                                          of        ship   
                    2.                                                                                    Deriv-    of     
                    Conver-                    5.                              7.                         ative     Deriv-   11.    
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature 
                    of                         Derivative    6.                of Underlying     8.       ities     Secur-   of     
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-    
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct 
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-  
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial 
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner- 
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship   
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>

Right to Purchase                                                                                         296,302   D     
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

====================================================================================================================================
</TABLE>
Explanation of Responses:

(1) Represents a sale of shares held by Bio-Sphere Technology, Inc. ("BTI"), a
corporation in which Dr. See is officer, director and shareholder.

(2) Reported holdings of non-derivative securities at month-end represent (a)
1,095,139 shares held by Dr. See in his individual capacity, (b) 707,250 shares
held by BTI, and (c) 100,000 shares of Common Stock held by the Wassgren Anita
See Trust, a trust in which Dr. See's spouse is the settlor and trustee (the
"Trust"). Dr. See disclaims beneficial ownership in all shares held by BTI other
than to the extent of his pecuniary interest therein and disclaims any
beneficial ownership in all shares held by the Trust. Excludes 296,302 shares
which Dr. See may be deemed to beneficially own by virtue of his right to
exercise a purchase right disclosed in Table II of this Form, the acquisition of
which was reported on a previously filed Form.


/s/  Jackie R. See, M.D.                                          9/9/98
- ---------------------------------------------            -----------------------
      **Signature of Reporting Person                             Date


**     Intentional misstatements or omissions of facts constitute Federal 
       Criminal Violations.

       See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this Form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedures.

       Alternatively, this Form is permitted to be submitted to the
       Commission in electronic format at the option of the reporting person
       pursuant to rule 101(b)(4) of Regulation S-T.


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