HARVARD SCIENTIFIC CORP
SC 13D, 1998-03-16
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                          (Amendment No.____________)*

                            HARVARD SCIENTIFIC CORP.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                     COMMON STOCK, PAR VALUE $0.01 PER SHARE
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                     417465200
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

       Jackie R. See, M.D., 100 No. Arlington, Suite 23-P, Reno, NV 89501
                                  (702)329-2255
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                        January 7, 1994-January 13, 1998(1)
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement of Schedule 13G to report
the acquisition which is the subject of the Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box [ ].

Note: Six copies of this statement, including all exhibits, should be filed with
the Commission. See Rule 13d-1(a) for other parties to whom copies are to be
sent.

*The remainder of this cover page shall be filed out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

- -------------------

         (1) Due to administrative errors, prior filings on Schedule 13D for 
this reporting person were not made. Accordingly, this Schedule sets forth
information regarding both current position as well as past activities.

                        (Continued on following page(s))


<PAGE>  2


CUSIP No.  417465200  13D

- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

       Jackie R. See, M. D., SS# ###-##-####
- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                      (a)  [  ]
                                      (b)  [ X]
- --------------------------------------------------------------------------------
   3   SEC USE ONLY

- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*
                                      OO
- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
       PURSUANT TO ITEMS 2(d) OR 2(e) [  ]

- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

                                      United States of America
- --------------------------------------------------------------------------------
   NUMBER OF               7    SOLE VOTING POWER
     SHARES                           1,401,441
  BENEFICIALLY      ------------------------------------------------------------
    OWNED BY               8    SHARED VOTING POWER
      EACH                            856,750
   REPORTING        ------------------------------------------------------------
     PERSON                9    SOLE DISPOSITIVE POWER
      WITH                            1,401,441
                    ------------------------------------------------------------
                           10   SHARED DISPOSITIVE POWER
                                      856,750
- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
       PERSON
                                      2,258,191
- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
       CERTAIN SHARES*
                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

                                      40.8%
- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

                                      IN
- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!





<PAGE>  3


CUSIP 417465200 Schedule 13D

ITEM 1.  SECURITY AND ISSUER

         This statement relates to the Common Stock par value $0.01 per share of
Harvard Scientific Corp. (the "Issuer"), 100 North Arlington Avenue, Suite 380,
Reno, Nevada 89501. All share amounts and dollar amounts per share have been
adjusted to reflect all Issuer stock splits to date.

ITEM 2.  IDENTITY AND BACKGROUND

         (I)      JACKIE R. SEE, M.D. Jackie R. See, M.D. has a business
                  address at 100 North Arlington Avenue, Suite 23-P, Reno,
                  Nevada 89501. He is the Chief Executive Officer, President, a
                  Director and majority stockholder of Bio-Sphere Technology,
                  Inc., a Nevada corporation ("BTI"). He is also a member of the
                  Board of Directors of the Issuer, a consultant to the Issuer
                  and the director of research of the Issuer. He has never been
                  convicted in any criminal proceeding (excluding traffic
                  violations or similar misdemeanors), nor was he ever a party
                  to any proceeding or subjected to a judgment, decree or final
                  order enjoining future violations, or prohibiting or mandating
                  activities subject to the federal or state securities law or
                  finding any violation with respect to such laws. He is an
                  American citizen.

         (II)     BIO-SPHERE TECHNOLOGY, INC. BTI is a Nevada biotechnology
                  research and development company with its principal office and
                  business located at 100 North Arlington, Suite 23-P, Reno,
                  Nevada 89501. BTI has never been convicted in any criminal
                  proceedings nor ever been a party to any proceeding or
                  subjected to a judgment, decree or final order enjoining
                  future violations, or prohibiting or mandating activities
                  subject to federal or state securities law or finding any
                  violation with respect to such laws.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

         (I)      JACKIE R. SEE, M.D. Prior to January 13, 1998, Dr. See did
                  not purchase any shares of Common Stock of the Issuer for
                  cash. On February 3, 1998, pursuant to the January 13, 1998
                  agreement described below, as amended on February 3, 1998 (the
                  "Financing Agreement"), Dr. See purchased 790,139 shares of
                  Common Stock at a per share purchase price of $3.164. Of the
                  aggregate purchase price for such shares, Dr. See paid
                  $7,901.39 in cash and delivered a promissory note payable to
                  the Issuer for the remaining balance of $2,492,098.61. The
                  promissory note is due March 31, 1999, bears interest at a
                  rate of 1% above prime and is secured by the shares purchased.
                  Dr. See's method of acquiring the shares of Common Stock of
                  the Issuer prior to January 13, 1998 otherwise than for cash
                  is described below:

                  Dr. See has received 356,750 shares of Common Stock of the
                  Issuer from the Issuer in payment for services rendered to the
                  Issuer. In particular, Dr. See received 19,750 shares in
                  1994, 2,000 shares on September 25, 1995, 35,000 shares on
                  March 18, 1997 and 300,000 shares on June 10, 1997. These
                  shares were valued at par value for purposes of these
                  issuances.



<PAGE>  4


         (II)     BIO-SPHERE TECHNOLOGY, INC. BTI did not purchase any shares of
                  Common Stock of the Issuer for cash. Its method of acquiring
                  the shares is described as follows:

                  On January 7, 1994, the Issuer entered into an Asset Purchase
                  Agreement with BTI whereby the Issuer acquired intellectual
                  property rights relating to prostaglandin microsphere delivery
                  in exchange for 71,400 shares of the Issuer's Common Stock.
                  These shares were valued at par value for purposes of such
                  issuances.

                  On November 16, 1995, the Issuer issued 613,850 shares of
                  Common Stock for BTI's assistance in management, raising
                  working capital, a patent application and distribution
                  agreements associated with the PGE-1 product. These shares
                  were valued at par value for purposes of such issuances.

                  On November 20, 1997, the board of directors of the Issuer
                  authorized a payment of $150,000 in cash, 200,000 shares of
                  the Issuer's Common Stock and a 3% gross override royalty to
                  be paid or acquired by BTI in exchange for the conveyance of
                  all the rights to Prostaglandin E-1 Lyophilized Liposomes used
                  in the treatment of Psoriasis. These shares were valued at par
                  value for purposes of such issuances.

ITEM 4.  PURPOSE OF TRANSACTION

         (I)      JACKIE R. SEE, M.D. The purpose of the transactions prior
                  to January 13, 1998 was for services rendered. The purpose of
                  the acquisition of shares on February 3, 1998 was to invest in
                  the Issuer and to assist in the capitalization of the Issuer
                  for financial reporting and regulatory purposes. The
                  acquisition of such shares was in accordance with the
                  Financing Agreement among the Issuer, Dr. See and Thomas E.
                  Waite, the Issuer's Chairman, President and Chief Executive
                  Officer. Under the Financing Agreement, each of Dr. See and
                  Mr. Waite purchased 790,139 shares of the Issuer's Common
                  Stock for cash and stock. In addition, the Financing Agreement
                  provides that prior to April 1, 1999, Dr. See and Mr. Waite
                  will have the right to purchase up to an additional aggregate
                  of 592,604 shares (or 296,302 shares each if such amount is
                  purchased equally, as contemplated). Of such additional
                  shares, the purchase price would be $6.238 for the first
                  395,070 shares purchasable and $12.656 for the remaining
                  197,534 shares purchasable. If purchased, such shares would be
                  paid for by way of cash in the amount of not less than the par
                  value of the purchased shares and delivery of a promissory
                  note for the remaining balance of the purchase price then due.
                  Any such promissory note would have substantially the same
                  terms as the notes delivered in connection with the February
                  3, 1998 purchases. The Issuer has indicated that it plans to
                  submit the Financing Agreement to its stockholders for
                  approval, which approval is anticipated in view of the number
                  of shares controlled by Dr. See and Mr. Waite. Because of
                  their mutual participation in the Financing Agreement, Dr. See
                  and Mr. Waite might be deemed to be a "group" for purposes of
                  Rule 13d-5(b); however, Dr. See expressly disclaims the
                  existence of any such group (and notes that Mr. Waite has
                  disclaimed any such status in his separate filing with respect
                  to this transaction).

         Dr. See has disposed of an aggregate of 41,750 shares of Common Stock
         of the Issuer from time to time, of which 31,000 shares were 
         transferred by way of gift and the remaining 10,750 shares were sold
         through brokerage sales.


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         (II)     BIO-SPHERE TECHNOLOGY, INC. The purpose of the transactions on
                  January 7, 1994, November 16, 1995 and October 9, 1997 was for
                  technology transfer and promotion of the business of the
                  Issuer. BTI has sold or otherwise disposed of 138,500 shares
                  of Common Stock of the Issuer from time-to-time by BTI through
                  brokerage sales, private transfers, or otherwise.

         Except for the acquisitions or dispositions of additional securities of
         the Issuer in the ordinary course of business through broker sales, and
         except as may be contemplated by the Agreement, Dr. See and BTI have no
         other plans or proposals which relate to or would result in any of the
         matters described in Items 4(a) through 4(j).

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER

         (a)      BENEFICIAL OWNERSHIP

                  (I)      JACKIE R. SEE, M.D. The aggregate number of
                           shares of Common Stock deemed to be beneficially
                           owned by Dr. See is 2,258,191 shares, or 40.8% of
                           the 5,534,349 shares deemed outstanding (including
                           296,302 shares which Dr. See may be deemed to have
                           the right to purchase under the Financing
                           Agreement). The shares that Dr. See may be deemed to
                           beneficially own consist of (A) the 1,105,139 shares
                           of Common Stock held by him, (B) the 746,750 shares
                           of Common Stock held by BTI, (C) the 110,000 shares
                           of Common Stock held by the Wassgren Anita See Trust
                           (Anita See is Dr. See's spouse), and (D) the 296,302
                           shares of Common Stock issuable to Dr. See upon
                           exercise of his rights to purchase additional shares
                           under the Financing Agreement. Dr. See disclaims
                           beneficial ownership of all except the shares held
                           or purchasable by him, other than to the extent of
                           his indirect interest in the BTI-held shares as a
                           stockholder of BTI.

                  (II)     BIO-SPHERE TECHNOLOGY, INC. The aggregate number of
                           shares of Common Stock of the Issuer beneficially
                           owned by BTI is 746,750 or 14.3% of the 5,238,047
                           shares of Common Stock of the Issuer currently
                           outstanding.

                  (III)    THOMAS E. WAITE. The aggregate number of
                           shares of Common Stock of the Issuer deemed to be
                           beneficially owned by Mr. Waite is 1,486,441 shares,
                           which includes the additional 296,302 shares that
                           may be acquired by Mr. Waite upon exercise of his
                           rights to purchase additional shares under the
                           Financing Agreement which holdings represent 26.9%
                           of the 5,534,349 shares deemed outstanding
                           (including 296,302 shares which Mr. Waite may be
                           deemed to have the right to purchase under the
                           Financing Agreement). As noted above, Dr. See
                           disclaims any designation of a group with Mr. Waite.

         (b)      POWER TO VOTE AND POWER TO DISPOSE

                  (I)      JACKIE R. SEE, M.D. Dr. See has sole voting and
                           dispository power over the 1,401,441 shares of
                           Common Stock of the Issuer held by him (including
                           296,302 shares purchasable by him under the
                           Financing Agreement). Dr. See has the shared voting
                           and dispository power over the 746,750 shares of
                           Common Stock of the Issuer held by BTI. Dr. See
                           shares voting and dispository power over the BTI
                           shares with Don A. Steffens, whose Item 2
                           information is as follows:


<PAGE>  6


                           Don A. Steffens has a business address at 100 North
                           Arlington Avenue, Suite 23-P, Reno, Nevada 89501. He
                           is the Vice President, Treasurer and a Director of
                           BTI. He has never been convicted in a criminal
                           proceeding (excluding traffic violations or similar
                           misdemeanors) nor has he ever been a party to any
                           proceeding or subjected to a judgment, decree or
                           final order enjoining future violations, or
                           prohibiting or mandating activities subject to
                           federal or state securities law or finding any
                           violation with respect to such laws. He is an
                           American citizen.

                           Although Dr. See has listed and disclaimed beneficial
                           ownership of the shares held by the Wassgren Anita
                           See Trust, he has no voting or dispository control
                           over such shares. Nonetheless, for disclosure
                           purposes, such shares are included in the shared
                           voting and dispository power category of the cover
                           page to this Schedule.

                  (II)     BIO-SPHERE TECHNOLOGY, INC. BTI has the sole voting
                           and dispository power over the 746,750 shares of
                           Common Stock of the Issuer held by it.

         (c)      TRANSACTIONS DURING THE LAST SIXTY DAYS

                  (I)      JACKIE R. SEE, M.D. See items 3 and 4 for
                           transactions within the last 60 days by Dr. See.

                  (II)     BIO-SPHERE TECHNOLOGY, INC. Within the 60 days prior
                           to the date of this Schedule, BTI has conducted the
                           following sales of Common Stock of the Issuer:

                  Date            Shares        Price/Sh.        Manner of Sale
                  ----            ------        ---------        --------------
                  1/16/98          300           $10.312          broker sale
                  1/16/98          100           $10.625          broker sale
                  1/20/98          400           $7.50            broker sale
                  1/21/98          400           $5.625           broker sale
                  1/22/98          400           $5.937           broker sale
                  1/23/98          400           $5.937           broker sale
                  1/26/98          270           $6.25            broker sale
                  1/26/98          130           $5.937           broker sale
                  1/27/98          250           $7.50            broker sale
                  1/27/98          150           $7.187           broker sale
                  1/28/98          400           $8.125           broker sale
                  1/29/98          1,550         $6.975           broker sale
                  1/29/98          400           $7.812           broker sale
                  1/29/98          250           $7.50            broker sale
                  1/29/98          150           $7.812           broker sale

<PAGE>  7

                  (III)    THOMAS E. WAITE. See Item 4 for transactions
                           within the last 60 days by Mr. Waite.

         (d)      RECEIPT OF DIVIDENDS AND PROCEEDS OF SALE.

                  No one not identified above has the right to receive dividends
                  or the proceeds from the sale of shares of Common Stock of the
                  Issuer owned by Dr. See, BTI or Mr.
                  Waite.

         (e)      Not applicable.

ITEM 6.  CONTRACTS, ARRANGEMENTS,  UNDERSTANDINGS OR  RELATIONSHIPS WITH RESPECT
TO SECURITIES OF THE ISSUER.

         See Items 3 and 4 for a discussion of arrangements regarding shares of
Common Stock of the Issuer.

ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS

         (1)      Consulting Agreement dated April 19, 1996 between the Issuer
                  and Dr. Jackie R. See, incorporated by reference to Exhibit
                  10.1 to Amendment #1 to the Registration Statement on Form
                  SB-2, Regis. #333-25647, filed June 24, 1997 (the "SB-2").

         (2)      Memorandum of Agreement dated May 15, 1997 amending the
                  Consulting Agreement between the Issuer and Dr. See of April
                  19, 1996, incorporated by reference to Exhibit 10.1A to the
                  SB-2.

         (3)      Agreement for the Acquisition of Intellectual Property Rights
                  dated January 7, 1994 between the Issuer and BTI, incorporated
                  by reference to Exhibit 10.6 to the SB-2.

         (4)      Exchange Agreement dated November 16, 1995 between the Issuer
                  and BTI, incorporated by reference to Exhibit 10.7 to the
                  SB-2.

         (5)      Financing Agreement dated January 13, 1998, as amended
                  February 3, 1998, among the Issuer, Dr. Jackie R. See and
                  Thomas E. Waite incorporated by reference to Exhibits A and B
                  to the Schedule 13D filed by Thomas E. Waite on March 5, 1998

         (6)     Agreement For The Acquisition Of Intellectual Property dated 
                 November 20, 1997 between the Issuer and BTI.

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         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.



Date: March 16, 1998                 /s/ Jackie R. See
                                    -----------------------------------
                                    Signature

                                    Jackie R. See, M.D.
                                    -----------------------------------
                                    Name/Title



<PAGE>  9
 
          AGREEMENT FOR THE ACQUISITION OF INTELLECTUAL PROPERTY RIGHTS



               This Agreement dated November 20th, 1997, is entered into by and
between Harvard Scientific Corp, a Nevada corporation with its principal address
at 100 North Arlington Avenue, Suite 380, Reno, Nevada 89501 (hereafter
"Harvard"), and Bio-Sphere Technology, Inc., a Nevada corporation with its
principal address at 100 North Arlington Avenue, Suite 23P, Reno, Nevada 89501
(hereafter "Bio-Sphere").

                                   WITNESSETH

               WHEREAS, Bio-Sphere is the owner of all rights, title and
interest in the intellectual property pertaining to Prostaglandin E-1
Lyophilized Liposomes for the use of treatment of Psoriasis, including, but not
limited to, any patents, patents pending or other proprietary ownership thereto.
Bio-Sphere hereto agrees to assign such said rights forthwith to Harvard.

               WHEREAS, upon receipt of the rights, title, and interest in the
intellectual property described above, Harvard agrees to exchange 2,000,000
shares of common stock of Harvard (the "Harvard Stock") plus $150,000 cash to
Bio-Sphere.

               NOW, THEREFORE, the parties hereto agree as follows:

        1. Bio-Sphere acknowledges that the shares of Harvard Stock to be issued
           it have not been registered under the Securities Act of 1933, as
           amended (the "Act") and may not be sold or transferred by Bio-Sphere
           accept in accordance with the provisions of the Act.

        2. The parties agree that the value of the additional technology and
           rights conveyed hereunder by Bio-Sphere (together with the other
           undertakings made by Bio-Sphere) is equal to the fair market value of
           the 2,000,000 shares of Harvard Stock being issued to Bio-Sphere
           hereunder.

        3. Harvard agrees with Bio-Sphere to use its best efforts to actively
           and diligently further develop, including obtaining regulatory
           clearance for, and promotion of, the commercial sale of the Product
           in the U.S. and elsewhere.



                                     Page 1

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        IN WITNESS WHEREOF, the parties have entered into this Agreement as of
        the day and year first set forth above.


                                           HARVARD SCIENTIFIC CORP.





        Dated ____________              BY: /S/ Thomas E. Waite
                                           ---------------------------------
                                        Thomas E. Waite, President & CEO





                                        BIO-SPHERE TECHNOLOGY, INC.





        Dated _____________             BY: /S/ Don Steffens
                                           ------------------------------------
                                        Don Steffens, Vice President & Director




                                     Page 2


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