SALIX PHARMACEUTICALS LTD
SC 13G/A, 2000-02-15
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                               (Amendment No. 1)*


                           Salix Pharmaceuticals, Ltd.
        ----------------------------------------------------------------
                                (Name of Issuer)



                                  Common Stock
               ---------------------------------------------------
                         (Title of Class of Securities)



                                   794906 3 05
                    -----------------------------------------

                                 (CUSIP Number)

                                December 31, 1999
           -----------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

         [ ]  Rule 13d-1(b)
         [ ]  Rule 13d-1(c)
         [X]  Rule 13d-1(d)
- ------------------------
         *The  remainder  of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes).



<PAGE>



- ------------------------------------------------------------
1.       Name of Reporting Person
         I.R.S. Identification No. of Above Person

         Randy W. Hamilton
- ------------------------------------------------------------
2.       Check the Appropriate Box if a Member of a Group
           (See Instructions)
                                                                       (a) ____
         Not Applicable                                                (b) ____
- ------------------------------------------------------------
3.       SEC Use Only


- ------------------------------------------------------------
4.       Citizenship or Place of Organization

            United States
- ------------------------------------------------------------

                           5.       Sole Voting Power

Number of                                   877,315
Shares                     ________________________________________
Beneficially               6.       Shared Voting Power
Owned By
Each Reporting
Person                     ________________________________________
                           7.       Sole Dispositive Power

                                            877,315
                           ----------------------------------------
                           8.       Shared Dispositive Power


- ------------------------------------------------------------
9.       Aggregate Amount Beneficially Owned by Each
           Reporting Person

                  877,315

- ------------------------------------------------------------
10.      Check if the Aggregate Amount in Row (9) Excludes
           Certain Shares (See Instructions)
<PAGE>

                  /   /

- ------------------------------------------------------------

11.      Percent of Class Represented by Amount in Row (9)

                  8.57%
- ------------------------------------------------------------
12.      Type of Reporting Person (See Instructions)

         IN
- ------------------------------------------------------------

<PAGE>

Item 1(a)         Name of Issuer

                  Salix Pharmaceuticals, Ltd.

Item 1(b)         Address of Issuer's Principal Executive Offices

                  3600 W. Bayshore Road, Suite 205, Palo Alto, CA 94303

Item 2(a)         Name of Person Filing

                  Randy W. Hamilton

Item 2(b)         Address of Principal Business Office, or, if None, Residence

                  3600 W. Bayshore Road, Suite 205, Palo Alto, CA 94303


Item 2(c)         Citizenship

                  United States


Item 2(d)         Title of Class of Securities

                  Common Stock


Item 2(e)         CUSIP Number

                  794906 3 05

Item 3.  Filing Pursuant to Rules 13d-1(b) or 13d-2(b)

                  Not Applicable

Item 4.  Ownership

                  (a)      Amount  beneficially owned: At December 31, 1999, Mr.
                           Hamilton  beneficially  owned an aggregate of 877,315
                           shares of the Issuer's  common  stock which  includes
                           options to  purchase  30,000  shares of the  Issuer's
                           common stock that were exercisable  within 60 days of
                           December 31, 1999. In addition, Mr. Hamilton's wife
                           holds 190,000 shares of the Issuer's common stock.
                           Mr. Hamilton disclaims beneficial ownership of the
                           shares held by his wife.


                  (b)      Percent of class:

                           8.57%

<PAGE>



                  (c)      Number of shares as to which such person has:

                           (i)      Sole power to vote or to direct the vote:
                                    877,315
                           (ii)     Shared power to vote or to direct the vote:
                           (iii)    Sole power to dispose or to direct the
                                    disposition of: 877,315
                           (iv)     Shared power to dispose or to direct the
                                    disposition of:


Item 5.  Ownership of Five Percent or Less of a Class

                           Not Applicable

Item 6.  Ownership of More than Five Percent on Behalf of Another Person

                           Not Applicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired the
                  Security Being Reported on By the Parent Holding Company

                           Not Applicable

Item 8.  Identification and Classification of Members of the Group

                           Not Applicable

Item 9.  Notice of Dissolution of Group

                           Not Applicable

Item 10. Certification

                           Not Applicable

<PAGE>

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

February 14, 2000
- --------------------------------------------
Date

/s/ Randy W. Hamilton
- --------------------------------------------
Randy W. Hamilton


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