SIGA PHARMACEUTICALS INC
8-K, 1998-04-22
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



         Date of Report (Date of earliest event reported) April 22, 1998

                           SIGA Pharmaceuticals, Inc.
             (Exact name of registrant as specified in its charter)

             Delaware                 0-23047                    13-864870
(State or other jurisdiction of  Commission File Number      (I.R.S. Employer
incorporation or organization)                            Identification Number)

               420 Lexington Avenue, Suite 620, New York, NY 10170
               (Address of principal executive offices) (zip code)

                                 (212) 672-9100
               (Registrant's telephone number including area code)

                                      None
              (Former name, former address and former fiscal year,
                          if changed since last report)




<PAGE>



Item 5 Other Events


On April 22, 1998, SIGA Pharmaceuticals, Inc. ("SIGA") announced a series of key
management changes  implemented by SIGA's Board of Directors that began with the
appointment  of  Walter  Flamenbaum,   M.D.,  as  President  in  February  1998.
Flamenbaum is a veteran of Therics, Inc., a Johnson and Johnson funded company.

Joshua  Schein,  Ph.D.,  a founder and director of SIGA,  has agreed to serve as
interim  CEO and Judson  Cooper,  M.B.A.,  a founder and  director of SIGA,  has
agreed to serve as interim Chairman,  until a permanent replacement can be found
for David de Weese,  who  resigned  as  Chairman  and CEO to join an  investment
management firm.

SIGA also  announced the  appointment  of Thomas N. Konatich as Vice  President,
Finance, and Chief Financial Officer, replacing Dr. Schein.

Mr. Konatich joins SIGA from Innapharma,  Inc., a privately held  pharmaceutical
development company,  where he served as CFO and Director with senior management
responsibilities in areas including accounting,  business development,  investor
relations,  risk  management  and legal  compliance.  From 1993-1996 he was Vice
President and CFO of Seragen,  Inc., a  biopharmaceutical  development  company.
While at  Seragen,  he had a key role in the  successful  completion  of several
financings  as well as the  development  of a  strategic  alliance  with a major
pharmaceutical  company.  Prior to joining  Seragen,  Mr. Konatich spent over 15
years  in key  financial  positions  in  the  biotechnology  and  pharmaceutical
industries.

Mr. Konatich  received his M.B.A. in Finance from Columbia  University  Graduate
School of Business in 1968 and earned a B.B.A. degree in Economics at St. John's
University in 1967.




<PAGE>



                                 SIGNATURE PAGE


     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.


                                          SIGA PHARMACEUTICALS, INC.


Date: April 22, 1998                      /s/ Joshua Schein, Ph.D.
                                          -------------------------
                                          Joshua Schein, Chief Executive Officer














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