SIGA PHARMACEUTICALS INC
PRER14A, 1999-12-10
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 14A

                                AMENDMENT NO. 1

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
                Proxy Statement Pursuant to Section 14(a) of the
                         Securities Exchange Act of 1934

Filed by the Registrant [X]
Filed by a Party other than the Registrant [_]

Check the appropriate box:

[X]  Preliminary Proxy Statement             [_]  Confidential, For Use of the
[ ]  Definitive Proxy Statement                   Commission Only (as permitted
[_]  Definitive Additional Materials              by Rule 14a-6(e)(2))
[_]  Soliciting Material Pursuant to
     Rule 14a-11(c) or Rule 14a-12


                           SIGA PHARMACEUTICALS, INC.
                (Name of Registrant as Specified In Its Charter)


    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X]  No fee required.
[_] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.


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3) Per unit price or other underlying value of transaction computed pursuant


<PAGE>


to  Exchange  Act Rule 0-11 (set forth the amount on which the filing fee is
calculated  and state how it was determined): __________________________________

4)  Proposed maximum aggregate value of transaction:____________________________

5)   Total fee paid:____________________________________________________________

     [_]  Fee paid previously with preliminary materials:

     [_] Check box if any part of the fee is offset as provided by Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the Form or Schedule and the date of its filing.

          1)   Amount previously paid:__________________________________________

          2)   Form, Schedule or Registration Statement No.:____________________

          3)   Filing Party:____________________________________________________

          4)   Date Filed:______________________________________________________



<PAGE>

                                December 20, 1999

Dear Shareholder:

1998-1999 has been an important period for SIGA. In September 1999, we announced
that we were evaluating  strategic  alternatives aimed at enhancing  shareholder
value  and  that  these  alternatives   included  the  possible  development  or
acquisition of an Internet technology.

In  December  1999,  we  announced  that we entered  into an  agreement  for the
acquisition  and further  development  of an Internet  communications  tool from
Open-i  Media,  Inc.,  a  New  York  based  software  and  web  developer.   The
client/server  application,  whose  working name is  PeerFinder,  is designed to
enable  real-time  peer-to-peer  communication  at or  between  web sites and to
facilitate the building of online communities.

PeerFinder is being  developed to make the Internet more dynamic and interactive
by enabling group or private  communication  that  complements the user's normal
surfing  habits.  PeerFinder  will travel with the user from site to site and is
not  restricted  to any single Web site,  portal or chat room.  By combining the
search for content with peer-to-peer  communication,  users will be able to more
easily locate information, transact business, solicit product reviews, or simply
converse on the topic at hand.

In 1998-1999,  we continued to make progress in the laboratory and in the clinic
on our lead  vaccine and  antibiotic  programs.  We received two SBIR grants and
several  patents  on  both  our  vaccine  and  antibiotic  technologies,  and we
announced  significant  management changes. In September 1999, we announced that
we would be  consolidating  our  biotechnology  assets  and  operations  in SIGA
Research Labs, a separate business unit based in Corvallis, Oregon, and that our
strategy would be to fund our ongoing vaccine and antibiotic  programs through a
combination of government grants, corporate partnerships and other alliances, as
we explore various strategic alternatives.

As we enter a new stage in the growth and  direction  of SIGA,  we would like to
thank our employees and you, our shareholders,  for your confidence, and we look
forward to reporting our continued progress.

Very sincerely yours,

Judson A. Cooper
Chairman

Joshua D. Schein, Ph.D.
Chief Executive Officer




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