CARDIOTECH INTERNATIONAL INC
8-K, 1999-07-30
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                                   ----------

                                    FORM 8-K

                                 CURRENT REPORT

                         Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934

                                   ----------

  Date of Report                              Date of earliest event reported
  July 30, 1999                                        July 16, 1999



                         CARDIOTECH INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)


                                    000-28034
                                   (Commission
                                  File Number)


 Massachusetts                                              04-3186647
(State or other                                           (IRS Employer
jurisdiction of                                         Identification No.)
incorporation)

                               78E Olympia Avenue
                                Woburn, MA 01801
               (Address of principal executive offices) (Zip Code)


Registrant's telephone number, including area code:  (781) 933-4772


<PAGE>



Item 2. Acquisition or Disposition of Assets

         On July 16,  1999,  CardioTech  International,  Inc.,  a  Massachusetts
corporation ("CardioTech"),  completed the acquisition of Tyndale Plains-Hunter,
Ltd., a New Jersey  corporation  ("TPH"),  pursuant to an Agreement  and Plan of
Merger,  dated  as of May  25,  1999  (the  "Merger  Agreement"),  by and  among
CardioTech,   CardioTech   Acquisition  Corp.,  a  Delaware  corporation  and  a
wholly-owned  subsidiary  of  CardioTech   ("Acquisition  Sub"),  and  TPH.  TPH
manufactures  hydrophilic  polyurethanes,  which are used to  provide  permanent
lubricity to the surface of medical devices, improve blood compatibility and act
as drug delivery systems and which are used in personal care products  including
hair creams, mousses and skin creams.  CardioTech intends to continue to use the
assets of TPH to manufacture hydrophilic polyurethanes.

         TPH  merged  with  and  into  Acquisition  Sub  (the  "Merger"),   with
Acquisition Sub surviving the Merger and remaining a wholly-owned  subsidiary of
CardioTech,  effective as of July 16,  1999.  Each share of TPH common stock was
(i)  converted  into the right to receive 0.24 of a share of  CardioTech  common
stock and (ii) exchanged for a cash payment of approximately $0.19. A portion of
the cash payment,  approximately  $.05, was placed into escrow pursuant to terms
of the Merger  Agreement.  The  conversion and exchange  ratios were  determined
through arm's length negotiation between the parties. The total number of shares
of CardioTech common stock and the total amount of cash issued in the Merger was
446,153 shares and $350,000,  respectively.  The cash  consideration used in the
Merger  came  from  CardioTech's  working  capital.  This  transaction  has been
recorded in accordance with the purchase method of accounting.

         The description contained herein of the transaction is qualified in its
entirety by  reference  to the Merger  Agreement  (Exhibit  2.1),  and a copy of
CardioTech's  press release  announcing the effectiveness of the Merger (Exhibit
99.1), copies of which are attached hereto and incorporated herein by reference.


Item 7. Financial Statements, Pro Forma Financial Information and Exhibits

     (a)  Financial statements of business acquired.

          Audited financial  statements of TPH, and the notes thereto,  required
     by this item  will be filed by  amendment  to this Form 8-K not later  than
     September 28, 1999.

     (b)  Pro forma financial information.

          The pro  forma  financial  information  required  by this Item will be
     filed by amendment to this Form 8-K not later than September 28, 1999.

<PAGE>


     (c)  Exhibits.

     The  following  exhibits are filed as part of this report  pursuant to Item
     601 of Regulation S-K:

          Exhibit
          -------
          Number         Description
          ------         -----------

          2.1  Agreement  and Plan of Merger  dated as of May 25,  1999,  by and
               among  CardioTech  International,  Inc.,  CardioTech  Acquisition
               Corp. and Tyndale Plains-Hunter, Ltd.

          99.1 CardioTech's Press Release dated July 19, 1999.


<PAGE>




                                   SIGNATURES


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
CardioTech  International,  Inc. has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized.


Date:  July 30, 1999                            CARDIOTECH INTERNATIONAL, INC.



                                                By:    /s/ Michael Szycher
                                                       -----------------------
                                                       Michael Szycher, Ph.D.
                                                       Chief Executive Officer


<PAGE>



                                  EXHIBIT INDEX



          Exhibit
          -------
          Number         Description
          ------         -----------

          2.1  Agreement  and Plan of Merger  dated as of May 25,  1999,  by and
               among  CardioTech  International,  Inc.,  CardioTech  Acquisition
               Corp. and Tyndale Plains-Hunter, Ltd.

          99.1 CardioTech's Press Release dated July 19, 1999.









                          AGREEMENT AND PLAN OF MERGER


                                  BY AND AMONG


                         CARDIOTECH INTERNATIONAL, INC.,


                          CARDIOTECH ACQUISITION CORP.

                                       AND


                           TYNDALE PLAINS-HUNTER, LTD.





                            DATED AS OF MAY 25, 1999


<PAGE>



                                TABLE OF CONTENTS

                                                                            PAGE


ARTICLE I  THE MERGER.........................................................1

   1.1. THE MERGER............................................................1
   1.2. EFFECTIVE TIME........................................................2
   1.3. EFFECTS OF THE MERGER.................................................2
   1.4. CONVERSION OF TPH SHARES..............................................2
      1.4.1. CONVERSION OF TPH STOCK INTO PARENT STOCK AND CASH...............2
      1.4.2. CANCELLATION OF TPH TREASURY STOCK WITHOUT PAYMENT...............2
      1.4.3. FRACTIONAL SHARES................................................2
      1.4.4. EFFECTIVE TIME...................................................3
   1.5. APPROVALS.............................................................3
   1.6. SUPPLEMENTARY ACTION..................................................3
   1.7. ACQUISITION SUB COMMON STOCK..........................................3
   1.8.  CERTIFICATE OF INCORPORATION, ETC. OF SURVIVING CORPORATION..........3
   1.9. BY-LAWS OF SURVIVING CORPORATION......................................4
   1.10. OFFICERS AND DIRECTORS OF SURVIVING CORPORATION......................4
   1.11. TAX CONSEQUENCES.....................................................4

ARTICLE II  THE MERGER CONSIDERATION..........................................4

   2.1. MERGER CONSIDERATION..................................................4
   2.2. PAYMENT FOR STOCK.....................................................4
      2.2.1. PAYMENT AT CLOSING...............................................4
      2.2.2. PAYMENT AFTER CLOSING............................................5
      2.2.3. GENERAL..........................................................5
   2.3. NO FURTHER TRANSFERS..................................................6

ARTICLE III  THE CLOSING......................................................6

      3.1. TIME AND PLACE.....................................................6
      3.2. TRANSACTIONS AT CLOSING............................................6

ARTICLE IV  REPRESENTATION AND WARRANTIES OF TPH..............................7

   4.1. ORGANIZATION; GOOD STANDING...........................................7
   4.2. POWER AND AUTHORITY...................................................7
   4.3. SUBSIDIARIES..........................................................8
   4.4. CAPITALIZATION OF TPH.................................................8
   4.5. NON-CONTRAVENTION.....................................................9
   4.6. GOVERNMENTAL CONSENTS.................................................9
   4.7. FINANCIAL STATEMENTS..................................................9
   4.8. TAXES.................................................................9
   4.9. ABSENCE OF CERTAIN CHANGES...........................................11
   4.10. LITIGATION, ETC.....................................................12
   4.11. REAL PROPERTY AND ENVIRONMENTAL MATTERS.............................13
   4.12. CONFORMITY TO LAW...................................................15
   4.13. INSURANCE...........................................................15
   4.14. CONTRACTS...........................................................16

                                       i
<PAGE>

   4.15. EMPLOYEE BENEFIT PLANS..............................................17
   4.16. INTELLECTUAL PROPERTY RIGHTS........................................18
   4.17. INDEBTEDNESS........................................................18
   4.18. LABOR RELATIONS.....................................................19
   4.19. BROKERS.............................................................19
   4.20. ACCOUNTS RECEIVABLE AND ACCOUNTS PAYABLE............................19
   4.21. INVENTORIES AND BACKLOG.............................................20
   4.22. EMPLOYEES...........................................................20
   4.23. CUSTOMERS AND VENDORS...............................................20
   4.24. DISTRIBUTORS AND REPRESENTATIVES....................................20
   4.25. PRODUCT WARRANTIES..................................................21
   4.26. ABSENCE OF QUESTIONABLE PAYMENTS....................................21
   4.27. OFFICERS AND DIRECTORS; BANK ACCOUNTS...............................21
   4.28. TITLE TO ASSETS.....................................................21
   4.29. NO DISSENTING RIGHTS................................................23
   4.30. DISCLOSURE..........................................................23

ARTICLE V  REPRESENTATION AND WARRANTIES OF PARENT AND ACQUISITION SUB.......23

   5.1. ORGANIZATION; GOOD STANDING..........................................23
   5.2. POWER AND AUTHORITY..................................................23
   5.3. NON-CONTRAVENTION....................................................24

ARTICLE VI  CONDUCT OF BUSINESS BY TPH PENDING CLOSING.......................24

   6.1. ACCESS...............................................................24
   6.2. CARRY ON IN REGULAR COURSE...........................................25
   6.3. NO DIVIDENDS OR GENERAL INCREASES....................................25
   6.4. SALES OF CAPITAL ASSETS..............................................25
   6.5. PRESERVATION OF ORGANIZATION.........................................25
   6.6 PRESERVATION OF REORGANIZATION........................................25
   6.7. NO AMENDMENTS TO CHARTER.............................................25
   6.8. ISSUANCE OF CAPITAL STOCK............................................25
   6.9. ACQUISITIONS.........................................................27
   6.10. TRANSACTIONS WITH AFFILIATES........................................27
   6.11. MATERIAL CONTRACTS..................................................27
   6.12. INSURANCE...........................................................27
   6.13. ACCOUNTING PRACTICES................................................27
   6.14. TAXES...............................................................27
   6.15. TERMINATION.........................................................27
   6.16. OTHER...............................................................28

ARTICLE VII  CONDUCT OF BUSINESS BY PARENT PENDING CLOSING...................28

   7.1. ACCESS...............................................................28
   7.2. PRESERVATION OF REORGANIZATION.......................................28

ARTICLE VIII  CONDITIONS PRECEDENT TO PARENT'S AND ACQUISITION SUB'S
              OBLIGATIONS....................................................29

   8.1. REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING.......................29
   8.2. COMPLIANCE WITH AGREEMENT............................................29
   8.3. OFFICER'S CERTIFICATE................................................29
   8.4. NO INJUNCTION........................................................29
   8.5. RESIGNATION OF DIRECTORS.............................................29
   8.6. NO MATERIAL ADVERSE CHANGE...........................................29
   8.7. CORPORATE PROCEEDINGS................................................30
   8.8. CONSENTS.............................................................30

                                       ii
<PAGE>

   8.9. TPH STOCKHOLDER APPROVAL.............................................30
   8.10. EMPLOYEES...........................................................30
   8.11. DUE DILIGENCE.......................................................30
   8.12. OPINION OF COUNSEL..................................................30
   8.13. SECTION 3.2 DELIVERIES..............................................31
   8.14. ESCROW AGREEMENT....................................................32
   8.15. QUESTIONNAIRES......................................................32
   8.16. CONSENT TO ASSIGNMENT...............................................32
   8.17. EXERCISE OF OPTIONS.................................................32
   8.18. INDEBTEDNESS........................................................32
   8.19. SECTION 4.11(B) PERMITS.............................................32
   8.20. SIC CODE............................................................33

ARTICLE IX  CONDITIONS PRECEDENT TO TPH'S OBLIGATIONS........................33

   9.1. REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING.......................33
   9.2. COMPLIANCE WITH AGREEMENT............................................33
   9.3. OFFICER'S CERTIFICATE................................................33
   9.4. CONSENTS.............................................................33
   9.5. CORPORATE PROCEEDINGS................................................33
   9.6. ESCROW AGREEMENT.....................................................35

ARTICLE X  CERTAIN UNDERSTANDINGS AND AGREEMENTS.............................35

   10.1. REGISTRATION OF SHARES..............................................35
   10.2. SHAREHOLDER MEETING.................................................35
   10.3. SUBSEQUENT FINANCIAL STATEMENTS.....................................35
   10.4. ADDITIONAL AGREEMENTS...............................................35
   10.5. ADVICE OF CHANGES, FAILURE OF CONDITIONS............................37

ARTICLE XI  CERTAIN DEFINITIONS..............................................37


ARTICLE XII  CONFIDENTIAL INFORMATION........................................38


ARTICLE XIII  INDEMNIFICATION................................................39

   13.1. INDEMNIFICATION.....................................................39
   13.2. CLAIMS..............................................................39
   13.3. METHOD AND MANNER OF PAYING CLAIMS..................................40
   13.4. LIMITS ON INDEMNIFICATION...........................................40
   13.5. SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS..............40

ARTICLE XIV  RIGHT TO TERMINATE..............................................41


ARTICLE XV  GENERAL..........................................................41

   15.1. EXPENSES............................................................41
   15.2. NONSURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS...........41
   15.3. NOTICES.............................................................42
   15.4. ENTIRE AGREEMENT....................................................43
   15.5. GOVERNING LAW.......................................................43
   15.6. CONSENT TO JURISDICTION.............................................43
   15.7. ARBITRATION.........................................................43
   15.8. SECTION HEADINGS....................................................43
   15.9. ASSIGNS.............................................................44

                                      iii
<PAGE>

   15.10. FURTHER ASSURANCES.................................................44
   15.11. NO IMPLIED RIGHTS OR REMEDIES......................................45
   15.12. COUNTERPARTS.......................................................45
   15.13. SATISFACTION OF CONDITIONS PRECEDENT...............................45
   15.14. PUBLIC STATEMENTS OR RELEASES......................................45

                                       iv

<PAGE>


EXHIBITS

Exhibit  A.........Delaware  Certificate of Merger
Exhibit  B.........New Jersey Certificate of  Merger
Exhibit  C.........Form  of  Escrow  Agreement
Exhibit  D.........Form of Letter of Transmittal
Exhibit  E.........Business Plan for TPH
Exhibit  F.........Form of Opinion of Counsel to TPH

                                       v

<PAGE>

                          AGREEMENT AND PLAN OF MERGER



         This  AGREEMENT AND PLAN OF MERGER  ("Agreement"),  dated as of May 25,
1999, by and among CardioTech  International,  Inc., a Massachusetts corporation
("Parent"),   CardioTech   Acquisition   Corp.,  a  Delaware   corporation   and
wholly-owned   subsidiary   of   Parent   ("Acquisition   Sub"),   and   Tyndale
Plains-Hunter, Ltd., a New Jersey corporation ("TPH").

         WHEREAS,  the Boards of  Directors of Parent,  Acquisition  Sub and TPH
have determined that it is in the best interests of their  respective  companies
and their  shareholders  to  consummate  the  business  combination  transaction
provided  for  herein,  in which TPH will  merge with and into  Acquisition  Sub
subject to the terms and conditions set forth herein (the "Merger");

         WHEREAS,  the  parties  intend  that the  Merger  qualify as a tax-free
reorganization  under Sections  368(a)(1)(A)  and  368(a)(2)(D)  of the Internal
Revenue Code of 1986, as amended (the "Code");

         WHEREAS,  contemporaneously  with the  execution  and delivery  hereof,
certain  stockholders  of TPH who  hold in the  aggregate  more  than 50% of the
outstanding shares of TPH's common stock, no par value, have delivered to Parent
irrevocable  proxies,  authorizing  Howard M. Nashel and Murray H. Reich to vote
all shares of capital  stock of TPH owned by them in favor of the Merger and the
transaction   contemplated   hereby  in  a  form  satisfactory  to  Parent  (the
"Proxies");

         WHEREAS, the parties desire to make certain representations, warranties
and  agreements  in  connection  with the Merger and also to  prescribe  certain
conditions to the Merger; and

         NOW,   THEREFORE,   in   consideration   of   the   mutual   covenants,
representations, warranties and agreements contained herein, and intending to be
legally bound hereby, the parties agree as follows:


                                    ARTICLE I

                                   THE MERGER

         1.1.     THE MERGER.

         Subject to the terms and  conditions of this  Agreement,  in accordance
with the Delaware  General  Corporation Law ("DGCL") and the New Jersey Business
Corporation  Act  ("NJBCA"),  at the  Effective  Time (as defined in Section 1.2
hereof),  TPH shall  merge  with and into  Acquisition  Sub  (such  corporations
sometimes referred to herein as the "Constituent  Corporations").  The surviving
corporation  in the Merger  shall be  Acquisition  Sub which shall  continue its
corporate  existence under the laws of the State of Delaware (referred to herein
when the  context so  requires as the  "Surviving  Corporation")  and shall be a
wholly owned  subsidiary of Parent after the Merger.  Upon  consummation  of the
Merger, the separate corporate existence of TPH shall terminate.

                                       1
<PAGE>

         1.2.     EFFECTIVE TIME.

         Upon the filing of an executed  certificate of merger in  substantially
the form of the attached Exhibit A (the "Delaware Certificate of Merger") in the
office of the  Secretary  of State of the State of Delaware and the filing of an
executed certificate of merger in substantially the form of the attached Exhibit
B (the "New Jersey  Certificate  of Merger") in the office of the  Secretary  of
State of the State of New Jersey,  the merger shall become  effective.  The date
and time of such  filings are referred to in this  Agreement  as the  "Effective
Time."

         1.3.     EFFECTS OF THE MERGER.

         At and after the Effective  Time, the Merger shall have the effects set
forth in Section 252 of the DGCL and Section 14A:10-7 of the NJBCA.

         1.4.     CONVERSION OF TPH SHARES.

         At the  Effective  Time, by virtue of the Merger and without any action
on the part of the holder of any securities of the Constituent Corporations:

                  1.4.1.   CONVERSION OF TPH STOCK INTO PARENT STOCK AND CASH.

                  Each share of TPH's common stock,  no par value ("TPH Stock"),
         then  outstanding,  other  than  shares  of TPH  Stock  to be  canceled
         pursuant to Section 1.4.2,  shall be  automatically  converted into and
         represent  the right to receive  the number of shares of common  stock,
         $.01 par value per share, of Parent ("Parent Stock") and the amounts in
         cash set forth in Section 2.1, payable as provided in Section 2.2.

                  1.4.2.   CANCELLATION OF TPH TREASURY STOCK WITHOUT PAYMENT.

                  Each  share  of TPH  Stock  held in  TPH's  treasury  shall be
         canceled and retired  without any conversion  thereof or payment of any
         consideration therefor.

                  1.4.3.   FRACTIONAL SHARES.

                  No  fractional  shares of Parent Stock will be issued,  but in
         lieu thereof  each holder of TPH stock who would  otherwise be entitled
         to a  fraction  of a share  of  Parent  Stock  (after  aggregating  all
         fractional  shares of Parent Stock to be received by such holder) shall
         receive from Parent an amount of cash  (provided  to the nearest  whole
         cent) equal to the product of such fraction multiplied by $1.625.

                                       2

<PAGE>



                  1.4.4.   EFFECTIVE TIME.

                  From and after the Effective Time, the holders of certificates
         representing  shares of TPH Stock  shall  cease to have any rights with
         respect to such  certificates  or such TPH  Stock,  except the right to
         receive the consideration specified in Sections 1.4.1. and 1.4.3.

         1.5.     APPROVALS.

         This Agreement shall be submitted to the  stockholders of TPH for their
approval  on or  about  June  17,  1999 in  accordance  with  the  NJBCA  and in
accordance with all other  applicable  laws.  Within fourteen (14) calendar days
after the  execution  and  delivery  of this  Agreement,  TPH shall  send to its
stockholders a Notice of Stockholders'  Meeting in form and substance acceptable
to the parties hereto (the "Notice").  Promptly after the Merger shall have been
approved by the  stockholders  of TPH, but in no event prior to the Closing Date
(defined in Section 3.1), the Delaware  Certificate of Merger and the New Jersey
Certificate  of Merger  shall be filed as  required  by the laws of the State of
Delaware and State of New Jersey, respectively.

         1.6.     SUPPLEMENTARY ACTION.

         If, at any time after the Effective  Time,  any further  assignments or
assurances  in law or any other things are  necessary or desirable to vest or to
perfect  or  confirm  of record in the  Surviving  Corporation  the title to any
property  or right of TPH,  or  otherwise  to carry out the  provisions  of this
Agreement, the officers and directors of the Surviving Corporation or Parent are
hereby  authorized and empowered on behalf of Surviving  Corporation and TPH, in
the name of and on behalf of the appropriate corporation, to execute and deliver
any and all things necessary or proper to vest or to perfect or confirm title to
such property or rights in Surviving Corporation, and otherwise to carry out the
purposes and provisions of this Agreement.

         1.7.     ACQUISITION SUB COMMON STOCK.

         Each share of common stock,  $.01 par value per share,  of  Acquisition
Sub, issued and outstanding immediately prior to the Effective Time, which shall
be the only shares of capital stock of Acquisition Sub outstanding  prior to the
Effective  Time and all of which shall be owned by Parent,  shall remain issued,
outstanding and unchanged after the Merger and shall  thereafter  constitute all
of the issued  and  outstanding  shares of the  capital  stock of the  Surviving
Corporation.

         1.8.     CERTIFICATE OF INCORPORATION, ETC. OF SURVIVING CORPORATION.

         The Certificate of Incorporation  of Acquisition Sub immediately  prior
to the Effective Time shall  continue as the  Certificate  of  Incorporation  of
Surviving Corporation at and after the Effective Time.

                                       3

<PAGE>



         1.9.     BY-LAWS OF SURVIVING CORPORATION.

         At and after the Effective  Time, the By-Laws of Acquisition  Sub shall
continue as the By-Laws of Surviving Corporation.

         1.10.    OFFICERS AND DIRECTORS OF SURVIVING CORPORATION.

         At  the  Effective  Time,  the  officers  and  Board  of  Directors  of
Acquisition  Sub  immediately  prior thereto shall  continue as the officers and
Board of Directors, respectively, of Surviving Corporation.

         1.11.    TAX CONSEQUENCES.

         It is intended that the Merger  constitute a reorganization  within the
meaning of Section 368(a) of the Code, and that this Agreement shall  constitute
a "plan of reorganization" for purposes of Section 368 of the Code.


                                   ARTICLE II

                            THE MERGER CONSIDERATION

         2.1.     MERGER CONSIDERATION.

         The aggregate merger consideration (the "Merger  Consideration")  shall
be $1,075,000, to be paid by Parent, as follows: (a) an amount equal to $250,000
in cash (the "Cash  Consideration") shall be paid to the stockholders of TPH pro
rata in accordance  with their  respective  percentages of ownership of TPH, (b)
446,153  shares  of Parent  Stock  (the  "Stock  Consideration"),  based  upon a
valuation of $1.625 per share,  shall be issued to the  stockholders  of TPH pro
rata in accordance  with their  respective  percentages of ownership of TPH, and
(c) $100,000 (the "Escrowed Funds") shall be deposited with Nashel Kates Nussman
Rapone Ellis & Traum,  LLP ("NKNRET") (or other  institution  selected by Parent
and TPH) as escrow agent (the "Escrow  Agent") on behalf of the  stockholders of
TPH for the  purpose of  providing a source of funds for  indemnification  under
Article XIII,  and shall be held,  administered  and  distributed  by the Escrow
Agent in accordance with the provisions of an escrow agreement  substantially in
the form of Exhibit C hereto (the "Escrow Agreement").

         2.2.     PAYMENT FOR STOCK.

                  2.2.1.   PAYMENT AT CLOSING.

                  Each registered  holder of TPH Stock shall have the right, but
         not the  obligation,  to  surrender  to  NKNRET,  counsel  to TPH ("TPH
         Counsel"),  at  least  five (5)  business  days  prior  to the  Closing
         (defined  in  Section  3.1)  the  certificate  or  certificates  which,
         immediately prior to the Effective Time,  represent shares of TPH Stock
         (the  "Certificates"),  together  with a duly  executed  and  completed
         letter of  transmittal  provided  by Parent  (which will  require  only
         reasonable  information  regarding  transmittal  of payment for the TPH
         Stock), which shall incorporate a release, substantially in the form of
         Exhibit D hereto (the "Letter of  Transmittal").  If a holder of shares
         of TPH Stock  delivers to TPH  Counsel,  for  delivery to Parent at the
         Closing  such  materials  at least five (5) days prior to the  Closing,
         such holder shall be entitled to receive in exchange  therefor  payment
         of an  amount  equal  to such  holder's  pro rata  portion  of the Cash
         Consideration  and  Stock  Consideration  at  the  Closing,   and  such
         Certificate or Certificates  shall forthwith be canceled.  In lieu of a
         Certificate or Certificates,  such holder may submit to TPH Counsel for
         delivery to Parent at the Closing at least five (5) business days prior
         to the Closing a lost  certificate  affidavit and indemnity in form and
         substance  satisfactory,  together with the Letter of  Transmittal,  to
         Parent.  For the  stockholders  of TPH who  have  properly  and  timely
         delivered  their  Certificates  and the  related  materials  or such an
         affidavit and indemnity,  in accordance with this Section 2.2.1, Parent
         shall, at the Closing, make to each (i) the required Cash Consideration
         payment by check made payable as set forth in the applicable letters of
         transmittal  and (ii)  the  required  Stock  Consideration  payment  by
         issuing stock  certificates  as set forth in the applicable  letters of
         transmittal.

                                       4
<PAGE>

                  2.2.2.   PAYMENT AFTER CLOSING.

                  As soon as practicable  after the Effective Time, Parent shall
         mail to each record holder (as of the Effective  Time) of TPH Stock who
         did not surrender his, her or its Certificate or Certificates or submit
         a lost certificate affidavit and indemnity at the Closing in accordance
         with Section 2.2.1, a notice and the Letter of Transmittal (which shall
         specify  that  delivery  shall  be  effected,  and  risk of loss of the
         Certificate or  Certificates  shall pass,  only upon proper delivery of
         the Certificate or Certificates to Parent) and  instructions for use in
         effecting the surrender of the Certificates for payment therefor.  Upon
         surrender to Parent of a Certificate or Certificates, together with the
         Letter of  Transmittal  duly  executed  and  completed  and such  other
         documents as may reasonably be required by Parent,  or upon delivery to
         Parent of a lost certificate affidavit and indemnity, together with the
         Letter of Transmittal,  the holder of such  Certificate or Certificates
         shall be entitled to receive in  exchange  therefor  (i) by check in an
         amount equal to such holder's pro rata portion (in accordance with his,
         her or its  percentage of share  ownership) of the Cash  Consideration,
         and (ii) stock certificates  representing  holder's pro rata portion of
         the  Stock   Consideration.   Such  Certificate  or  Certificates,   if
         surrendered, shall forthwith be canceled.

                  2.2.3.   GENERAL.

                  No  interest  shall  be paid or  shall  accrue  on the  amount
         payable  upon the  surrender of any  Certificate  or delivery of a lost
         certificate  affidavit and indemnity,  on the condition that payment is
         made promptly as required  herein.  Payments  shall only be made to the
         person in whose name a Certificate so surrendered is registered.  Until
         surrendered in accordance with the provisions of this Section 2.2, each
         Certificate  shall  represent  for all  purposes  only the right of the
         holder  thereof to receive such holder's pro rata portion of the Merger
         Consideration,  without any interest thereon.  The Merger Consideration
         paid to  stockholders  of TPH shall be deemed to have been paid in full
         satisfaction of all rights  pertaining to the TPH Stock  represented by
         such Certificates.

                                       5
<PAGE>

         2.3.     NO FURTHER TRANSFERS.

         After the date  hereof,  there  shall be no  further  registrations  of
transfers  on the  stock  transfer  books  of TPH of  shares  of TPH  Stock.  If
Certificates  are  presented to Parent after the Effective  Time,  they shall be
canceled and  exchanged  for pro rata  portions of the Merger  Consideration  as
provided in this Agreement.


                                   ARTICLE III

                                   THE CLOSING

         3.1.     TIME AND PLACE.

         The closing of the  transactions  contemplated  hereby (the  "Closing")
shall be held at the offices of Mintz,  Levin, Cohn, Ferris,  Glovsky and Popeo,
P.C., One Financial Center, Boston, Massachusetts, as promptly as practicable on
the day of and immediately following the satisfaction or waiver (if waivable) of
all of the  conditions  set forth in Articles VIII and IX, or at such other time
and/or  other  place as the  parties  may agree or by telecopy if the parties so
agree.  The date on which the Closing is actually  held  hereunder  is sometimes
referred to herein as the "Closing Date."

         3.2.     TRANSACTIONS AT CLOSING.

         At the  Closing,  TPH  shall  deliver  to  Parent  the  following:  (i)
certificates  dated as of dates not more than ten (10) days prior to the Closing
Date,  from the  Secretary  of  State  of the  State  of New  Jersey  and  other
appropriate  authorities  as to the good  standing of, and  qualification  to do
business of, TPH in each jurisdiction where it is so qualified; (ii) certificate
dated as the Closing Date from the  treasurer and president of TPH as to payment
of taxes by TPH in each jurisdiction where it is qualified to do business; (iii)
the Certificate of  Incorporation of TPH certified by the secretary of TPH to be
true and complete copies at and as of the Closing;  (iv) the stock books,  stock
ledgers,  minute  books  and  corporate  seal of  TPH;  (v)  noncompetition  and
confidentiality  agreements with Mr. James Knox and Ms. Jirina Kuzma and in form
mutually satisfactory to Mr. Knox and Ms. Kuzma, respectively,  and Parent; (vi)
a letter from each  director and officer of TPH  acknowledging  that each has no
claim  against TPH for  compensation  for loss of office,  unfair  dismissal  or
otherwise,  as directed by Parent;  (vii) insofar as they are not in the custody
of TPH,  TPH's  financial  books and  records;  and (viii) all other  previously
undelivered  items  required to be  delivered  by TPH at or prior to the Closing
pursuant to this Agreement unless waived in writing by Parent.

         At or prior to the Closing,  TPH shall also have: (i) duly executed and
delivered  the  Delaware  Certificate  of Merger and New Jersey  Certificate  of
Merger to Parent, (ii) delivered to Parent an estoppel certificate,  in form and
substance  satisfactory to TPH and Parent relating to the property leased by TPH
in Lawrenceville,  New Jersey, (iii) a consent by TPH and Aortech Europe Limited
("Aortech") to the assignment to Acquisition Sub of the License Agreement, dated
May 9,  1996,  between  TPH and  Aortech  and (iv) a consent  by TPH and  Helene
Curtis,  Inc.  ("HCI") to the  assignment to  Acquisition  Sub of the Evaluation
Agreement  between  TPH and HCI,  effective  January 1, 1994,  as  amended;  the
Marketing  Exclusivity Agreement between TPH and HCI, effective October 1, 1997;
and the Agreement between TPH and HCI, effective February 1, 1997.

                                       6
<PAGE>

         At or prior to the Closing,  Parent, or Acquisition Sub, as applicable,
shall have:  (i) duly executed and delivered the Delaware  Certificate of Merger
and New Jersey  Certificate  of Merger to TPH; (ii) delivered the Escrowed Funds
to the Escrow Agent (which shall be deemed to have been paid to the stockholders
of TPH pro rata and deposited in escrow with the Escrow Agent on their  behalf);
and (iii) paid the Cash Consideration and issued the Stock  Consideration to the
stockholders of TPH as provided in Section 2.2.1.


                                   ARTICLE IV

                      REPRESENTATION AND WARRANTIES OF TPH

         TPH  represents  and  warrants  to Parent  as  follows,  and  Parent in
agreeing to  consummate  the  transactions  contemplated  by this  Agreement has
relied upon such representations and warranties:

         4.1.     ORGANIZATION; GOOD STANDING.

         TPH is a  corporation  duly  organized,  validly  existing  and in good
standing under the laws of the State of New Jersey.  TPH has delivered to Parent
true and complete copies of its certificate of incorporation and by-laws and all
amendments  thereto.  The minute  books and  records of TPH which have been made
available to Parent  prior to the date hereof are the original  minute books and
records  of TPH and are  true and  complete  and  there  have  been no  changes,
alterations  or additions  thereto which have not been  furnished to counsel for
Parent prior to the date hereof.  TPH is duly qualified to do business and is in
good standing in each  jurisdiction  in which the  properties  owned,  leased or
operated  by it or the  nature  of  the  business  conducted  by it  makes  such
qualification  necessary,  except where  failure to be so qualified  and in good
standing  would not have a material  adverse  effect on the business of the TPH.
TPH is not in violation of any provision of its certificate of  incorporation or
by-laws or any agreement with any of its shareholders.

         4.2.     POWER AND AUTHORITY.

         TPH has full  corporate  power and  authority  to execute,  deliver and
perform  its  obligations  under this  Agreement  and all  agreements  and other
documents  executed  and  delivered,  or to be  executed  and  delivered,  by it
pursuant  to this  Agreement  and,  except for the vote of its  stockholders  to
approve this  Agreement  and the calling of such meeting at which such vote will
be taken,  has taken all action  required by its  certificate of  incorporation,
by-laws or otherwise,  to authorize the execution,  delivery and  performance of
the  Agreement  and  such  related   documents  and  the   consummation  of  the
transactions contemplated hereby and thereby. The execution and delivery of this
Agreement by TPH do not and, subject to the receipt of the requisite vote of its
stockholders  as aforesaid,  the  consummation of the Merger by TPH will not (i)
conflict with or violate any provisions of the certificate of incorporation  and
by-laws of TPH, or (ii) constitute a breach of or default, or give rise, with or
without  notice  or lapse  of time,  to any  third-party  right of  termination,
cancellation,  material  modification  or  acceleration  under any  note,  bond,
mortgage,  pledge, lien, lease,  agreement,  license,  commitment or instrument,
applicable to TPH, or conflict with or violate any  restrictions  of any kind to
which any of them is subject,  and/or result in the creation of any lien, charge
or other encumbrance or Tax on or against any assets, rights or property of TPH.
This Agreement has been duly executed and delivered by TPH and  constitutes  the
legal,  valid  and  binding  obligations  of  TPH  enforceable  against  TPH  in
accordance with its terms.  The affirmative  vote of the shares of a majority in
interest of the shares of TPH Stock as well as the  officers  and  directors  of
TPH,  and subject to the  Proxies  will be  sufficient  to approve the Merger in
accordance  with  the  requirements  of  the  NJBCA  and  TPH's  Certificate  of
Incorporation and Bylaws. The Proxies are legal, valid and effective under NJBCA
and the Certificate of Incorporation and Bylaws of TPH.

                                       7
<PAGE>

         4.3.     SUBSIDIARIES.

         TPH does not own or hold,  beneficially and/or of record, any shares of
any class of the capital stock or other equity  securities  (as the term "equity
security"  is defined  under the  Securities  Exchange  Act of 1934,  as amended
("Exchange  Act")) of any other  corporation  and has no other  type of legal or
beneficial  interest  (whether  ownership  or other)  in any other  corporation,
limited  liability  company,   partnership,   joint  venture,   business  trust,
unincorporated  trade or business  enterprise  or other  business  organization,
entity or  association  of any kind.  TPH is not subject to any  obligations  or
requirements  to provide funds for, or to make any  investment (in the form of a
loan, capital contribution or otherwise) to or in, any Person.

         4.4.     CAPITALIZATION OF TPH.

         The authorized capital stock of TPH consists solely of 5,000,000 shares
of Common  Stock,  no par  value,  1,836,342.305  shares of which are issued and
outstanding  on the date hereof and 53,000  shares of Common  Stock of which are
held by TPH as  treasury  shares.  All of the  shares of TPH  Stock are  validly
issued and outstanding,  fully paid and  non-assessable  and are owned of record
and  beneficially  as set forth on Schedule  4.4 hereto.  Except as set forth on
Schedule  4.4,  there  are  no  outstanding  subscriptions,  options,  warrants,
pre-emptive  rights or other rights to purchase or acquire any equity securities
of TPH, no  securities  of TPH are reserved for issuance for any purpose,  there
are no  contracts,  commitments,  agreements,  understandings,  arrangements  or
restrictions to which TPH is a party or by which of TPH is bound relating to any
shares of the capital stock or other equity  securities  of TPH,  whether or not
outstanding,  and there are no stock  appreciation  rights or "phantom stock" or
similar rights with respect to TPH. There are no outstanding TPH debt securities
or other instruments issued by TPH or to which TPH or any other person or entity
is a party,  entitling  the  holders  thereof to vote or to direct or  otherwise
restrict the vote of the holders of TPH Stock or which are  convertible  into or
exchangeable  for  voting  securities  of  TPH.  There  is no  liability  for or
obligations  with respect to any dividends  declared or  accumulated  but unpaid
with respect to any shares of TPH capital stock.

         4.5.     NON-CONTRAVENTION.

                                       8
<PAGE>


         Neither the  execution  and  delivery of this  Agreement by TPH nor the
consummation by TPH of the  transactions  contemplated  hereby will constitute a
violation of, or be in conflict  with, or constitute or create a default  under,
or result in the creation or imposition of any lien,  claim or encumbrance  upon
any property of TPH pursuant to: (i) the certificate of incorporation or by-laws
of TPH,  each as amended to date;  (ii) any agreement or commitment to which TPH
is a party or by which TPH or its properties is bound or any of such  properties
is subject,  or (iii) any statute or any judgment,  decree,  order regulation or
rule of any court or governmental authority.

         4.6.     GOVERNMENTAL CONSENTS.

         No   consent,   approval   or   authorization   of,  or   registration,
qualification  or filing  with,  any  governmental  agency or authority or third
party is required for the execution and delivery of this Agreement by TPH or for
the  consummation  by TPH of the  transactions  contemplated  hereby  except the
filings described in Section 1.5.

         4.7.     FINANCIAL STATEMENTS.

         TPH has  delivered the following  financial  statements to Parent,  and
they are attached as Schedule 4.7 hereto:  the  unaudited  consolidated  balance
sheet of TPH as of March 31, 1998 (the "1998  Balance  Sheet"),  and the related
unaudited  statements  of income and retained  earnings for the fiscal year then
ended (the "1998 Fiscal Year End  Financial  Statements").  The 1998 Fiscal Year
End  Financial  Statements  have been  prepared  in  accordance  with  generally
accepted  accounting  principles  consistently  applied  and fairly  present the
financial  position  of the  Company as of March 31, 1998 and the results of its
operations  and cash flows for the fiscal year ended March 31,  1998.  Except as
set forth on Schedule 4.7 hereto, TPH has no liability or obligation  (absolute,
accrued,  contingent or  otherwise),  including any guaranty with respect to any
obligation,  except such  liabilities  or  obligations  as are fully  reflected,
reserved  against or disclosed in the 1998 Fiscal Year End Financial  Statements
or such as have arisen in the ordinary  course of business since the date of the
1998 Fiscal Year End Financial Statements; provided that this sentence shall not
apply to liabilities  or obligations  (if any) which are not required by GAAP to
be reflected, reserved against or disclosed therein.

         4.8.     TAXES.

         (a) Except as set forth on Schedule  4.8 hereto,  TPH, has timely filed
with each appropriate  federal,  state, local and foreign governmental entity or
other  authority  (individually  or  collectively,  "Taxing  Authority") all Tax
Returns (as defined in Section 4.8(d)) required to be filed and have timely paid
in full all Taxes (as defined in Section 4.8(c)) if any, shown to be due on such
Tax Returns,  or otherwise have made appropriate  accruals for or paid all other
Taxes allocable to taxable  periods or portions  thereof ending on or before the
Closing Date. No Taxes for the periods  covered by such Tax Returns are required
to be paid that  have not been  reserved  for on the books of TPH.  There are no
liens for Taxes upon TPH or its assets  except  liens for current  Taxes not yet
due. TPH has delivered to Parent  complete copies of all the Tax Returns of TPH,
for the five (5) most recently completed taxable years, all examination  reports
by any Taxing Authority, and any statements of deficiencies proposed or assessed
against or agreed by TPH.  Except as set forth on Schedule 4.8 hereto,  no facts
exist that shall have caused TPH to believe that there are or may be grounds for
the  assessment  against it of any  additional  Taxes by any  Taxing  Authority.
Except  as set  forth on  Schedule  4.8  hereto,  no  examination  or  notice of
potential  examination  of the Tax  Returns  of TPH by any Taxing  Authority  is
pending, and no extension of any statute of limitations has been granted for the
assessment of any Taxes.

                                       9
<PAGE>

         (b) Except as set forth on Schedule 4.8 hereto,  all Taxes with respect
to TPH that are required to be withheld or collected  have been duly withheld or
collected and, to the extent required, have been paid to the proper governmental
authorities or properly deposited as required by applicable laws.

         (c) As used in this Agreement, "Tax" means any of the Taxes and "Taxes"
means,  with respect TPH,  (i) all income taxes  (including  any tax on or based
upon net income, or gross income, or income as specially  defined,  or earnings,
or profits,  or  selected  items of income,  earnings or profits)  and all gross
receipts, sales, use, ad valorem,  transfer,  franchise,  license,  withholding,
payroll, employment, excise, severance, stamp, occupation,  premium, property or
windfall  profit taxes,  alternative or add-on  minimum taxes,  custom duties or
other taxes, fees, assessments or charges of any kind whatsoever,  together with
any interest and any penalties,  additions to tax or additional  amounts imposed
by any Taxing  Authority  on TPH and (ii) any  liability  for the payment of any
amount of the type described in the immediately preceding clause (i) as a result
of being a  "transferee"  (within  the  meaning of Section  6901 of the Code (as
defined in Article 9) or any other applicable law) of another Person or a member
of an affiliated or combined TPH.

         (d) As used in this Agreement, "Tax Return" means any return, report or
information  return (including any related or supporting  information)  filed or
required to be filed with any Taxing  Authority or other authority in connection
with the  determination,  assessment or collection of any Tax paid or payable by
TPH  or  the   administration   of  any  laws,   regulations  or  administrative
requirements relating to any such Tax.

         (e)  Schedule 4.8 hereto  lists each  jurisdiction  in which TPH either
files Tax Returns or pays Taxes with respect to which no returns are required to
be filed, and any action, suit,  proceeding,  investigation,  audit or claim now
pending  against  TPH in respect of any Tax.  Except as listed on  Schedule  4.8
hereto,  no claim has ever been made by any Taxing  Authority in a  jurisdiction
where TPH does not file Tax Returns  that it is or may be subject to taxation by
that jurisdiction.

         (f) No property owned by TPH is property that such Person is or will be
required to treat as being owned by another person pursuant to the provisions of
Section 168(f)(8) of the Internal Revenue Code of 1954, as amended and in effect
immediately  prior  to the  enactment  of the  Tax  Reform  Act of  1986,  or is
"tax-exempt use property" as defined in Section 168(h) of the Code.

         (g) TPH has never  agreed to or been  required  to make any  adjustment
pursuant  to Section  481(a) of the Code by reason of any  change in  accounting
methods  initiated by such Person;  the IRS has not proposed any such adjustment
or change in  accounting  method;  and TPH has no  application  pending with any
Taxing Authority requesting permission for any changes in accounting methods.

                                       10
<PAGE>

         (h) TPH, is not now,  and during the  applicable  period  specified  in
Section  897(c)(A)(ii)  of the Code has not been, a United  States real property
holding corporation as defined in Section 897(c)(2) of the Code.

         (i) TPH is not now,  and has  never  been,  a party  to any  agreement,
contract, arrangement or plan that would result, separately or in the aggregate,
in the payment of any "excess parachute  payments" within the meaning of Section
280G of the Code.

         (j) TPH has not filed a consent pursuant to Section 341(f) of the Code,
and  has  not  agreed  to  have  Section  341(f)(2)  of the  Code  apply  to any
disposition  of a Section  (f)  asset (as such  terms  are  defined  in  Section
341(f)(4) of the Code) owned by it.

         (k) Except as described  on Schedule  4.8 hereto,  TPH has never been a
member of an affiliated  Group of corporations (as defined in Section 1504(a) of
the Code) or filed or been  included  in a  combined,  consolidated,  or unitary
income Tax Return.

         (l) Except as described  on Schedule 4.8 hereto,  TPH is not an obligor
on, and none of their respective assets has been financed directly or indirectly
by, any tax-exempt bonds.

         (m) Except as described on Schedule 4.8 hereto, TPH has not executed or
entered  into a closing  agreement  pursuant to Section  7121 of the Code or any
predecessor  prevision  thereof  or any  similar  provision  of state,  local or
foreign law that relates to their respective assets or operations.

         (n) TPH is not a party to any Tax  allocation or sharing  agreement and
has no  contractual  obligation  to  indemnify  any other Person with respect to
Taxes.

         (o) TPH does not have  pending  any  request  for a revenue  or private
letter ruling.

         (p) TPH has not been a personal  holding  company  with the  meaning of
Section 542 of the Code during the five-year  period  immediately  preceding the
date hereof.

         4.9.     ABSENCE OF CERTAIN CHANGES.

         Except as set forth on Schedule 4.9 hereto or as  contemplated  hereby,
since the date of the 1998  Balance  Sheet,  TPH has  conducted  its  respective
business  only  in the  ordinary  course  and  there  has not  occurred  (a) any
acquisition  or sale,  transfer  or  other  disposition  by TPH of any  asset or
property  other than  inventory  in the  ordinary  course of  business;  (b) any
damage,  destruction  or loss whether or not covered by insurance,  in excess of
$5,000 in the aggregate;  (c) any  declaration,  setting aside or payment of any
dividend or any other  distributions  in respect of the  capital  stock or other
equity securities of TPH except as permitted under Section 6.3; (d) any issuance
of any shares of the capital stock of TPH or any direct or indirect  redemption,
purchase  or other  acquisition  of any of the  capital  stock  or other  equity
securities  of TPH  (e) any  increase  in the  compensation,  pension  or  other
benefits  payable  or to  become  payable  by TPH to  any  of  its  officers  or
employees,  or any bonus  payments or  arrangements  made to or with any of them
(other than annual or periodic increases made in the ordinary course of business
consistent with such Person's past  practice);  (f) any incurrence by TPH of any
obligations or liabilities,  whether absolute,  accrued, contingent or otherwise
(including,  without  limitation,  liabilities  as guarantor  or otherwise  with
respect to  obligations  of  others),  other than  obligations  and  liabilities
incurred in the ordinary course of business or as contemplated  hereby;  (g) any
discharge or  satisfaction by TPH of any material lien or encumbrance or payment

                                       11
<PAGE>


by TPH of any  obligation  or  liability  (fixed  or  contingent)  in an  amount
exceeding  $5,000 other than in the ordinary course of business;  (h) any change
in any assumptions  underlying or methods of calculating any debt,  contingency,
or  other  reserve  of  TPH;  (i)  any  write-down  in the  value  of any of the
inventories  of TPH;  (j) any  write-off  of any  account  receivable  of TPH as
uncollectable   except  for  write-offs  in  the  ordinary  course  of  business
consistent with past practice;  (k) any cancellation of any debt or claim or any
waiver of any  right of in an  amount  exceeding  $5,000;  (l) any  disposition,
assignment,  transfer or lapse of any right of TPH to use any patent, trademark,
trade name,  copyright,  know-how  or  process;  (m) any change in any method of
accounting  or in any  accounting  practice of TPH; (n) any payment,  other than
salary  payments to  employees  of TPH,  loan or advance by TPH to, or any sale,
transfer or lease of any of such Person's  properties or assets to, or any other
contract, commitment, agreement, understanding, arrangement or transaction with,
any  officer,  director  or  shareholder  of such  Person;  (o) the  creation or
imposition of any lien on TPH's  properties  or assets;  (p) the loss or, to the
knowledge of TPH,  the  reasonable  likelihood  of the  prospective  loss of any
customer, vendor or distributor listed on Schedule 4.23 or Schedule 4.24 hereto;
(q) any  capital  expenditures  by TPH in excess of $5,000;  (r) any  agreement,
whether in writing or otherwise,  to take any of the foregoing actions described
in this Section; or (s) any material adverse change in the business, properties,
assets, liabilities, condition (financial or otherwise) or prospects of the TPH,
taken as a whole.

         4.10.    LITIGATION, ETC.

         Except as set forth on Schedule 4.10 hereto,  no claim,  action,  suit,
proceeding or investigation is pending or, to TPH's knowledge,  threatened by or
against TPH nor is there any judgment, decree, injunction,  rule or order of any
court or other governmental  entity or any arbitrator  outstanding  against TPH.
Except as set forth on Schedule  4.10  hereto,  no material  claims,  including,
without  limitation,  product liability  claims,  have been asserted against TPH
during  the past five (5)  years  and TPH is not  aware or has any  reason to be
aware  of any  basis  for  any  material  action,  proceeding  or  investigation
involving TPH, other than as set forth on Schedule 4.10 hereto.

                                       12

<PAGE>



         4.11.    REAL PROPERTY AND ENVIRONMENTAL MATTERS.

         (a) (i) Schedule  4.11(a)  identifies all of the real property that TPH
         leases,  has agreed to lease or has  obligation  to lease  (including a
         general  description  of the  improvements  thereon),  in each  case as
         Lessee.  Such leased real  property is  hereinafter  referred to as the
         "Leased  Property,"  and the  improvements  and  fixtures  thereon  are
         hereinafter referred to as the "Leased Improvements."  Schedule 4.11(a)
         identifies  all of the real property  formerly  leased by TPH. TPH does
         not own and has never owned any real property.

                  (ii) There are no adverse or other  parties in  possession  of
         the Leased Property, the Leased Improvements or any portion or portions
         thereof,  and on the Closing Date the leasehold interests in the Leased
         Property and the Leased  Improvements will be free and clear of any and
         all  leases,   licensees,   occupants   or  tenants  and  all  material
         conditions,    exceptions,     reservations,    liens,    restrictions,
         rights-of-way, easements, encumbrances and other matters affecting such
         Leased Property,  Improvements and leasehold  interests;  except as set
         forth on Schedule 4.11(a) hereto.  The transactions  contemplated under
         this  Agreement  do not  require  consents by any  landlords  under the
         Leased Property or Leased Improvements.

         (b)      Except as set forth on Schedule 4.11(b):

                  (i) TPH is not or has not been in violation  of any  judgment,
         decree,   order,  law,  license,   rule  or  regulation  pertaining  to
         environmental  matters,  including,  without limitation,  those arising
         under  the  Resource  Conservation  and  Recovery  Act  ("RCRA"),   the
         Comprehensive Environmental Response, Compensation and Liability Act of
         1980   as   amended   ("CERCLA"),    the   Superfund   Amendments   and
         Reauthorization Act of 1986 ("SARA"),  the Federal Clean Water Act, the
         Occupational  Safety and Health  Act,  the Federal  Clean Air Act,  the
         Toxic Substances  Control Act, and any state, local or foreign statute,
         regulation,  ordinance,  order or decree relating to health,  safety or
         the environment ("Environmental Laws");

                  (ii)  Neither TPH nor any of its  respective  predecessors  in
         interest has received  written  notice from any third party  including,
         without limitation, any federal, state or local governmental authority,
         nor does TPH  otherwise  have reason to  believe,  (i) that it has been
         identified by the United States  Environmental  Protection  Agency as a
         potentially  responsible  party  under  CERCLA  with  respect to a site
         listed on the National  Priorities List, 40 C.F.R.  Part 300 Appendix B
         (1986);  (ii)  that  any  hazardous  waste,  as  defined  by 42  U.S.C.
         ss.6903(5),   any   hazardous   substance   as  defined  by  42  U.S.C.
         ss.9601(14),  any  pollutant  or  contaminant  as  defined by 42 U.S.C.
         ss.9601(33) and any toxic substance, oil or hazardous material or other
         chemical or substance  regulated by any Environmental  Laws ("Hazardous
         Substances") which it has generated, transported, stored or disposed of
         has been found at any site at which a federal, state or local agency or
         other  third  party has  conducted  or has  ordered  that it  conduct a
         remedial  investigation,  removal or other response  action pursuant to
         any  Environmental  Law; or (iii) that it is or may be a named party to
         any  claim,   action,  cause  of  action,   complaint   (contingent  or
         otherwise),  investigation,  legal or administrative proceeding arising
         out of any  third  party's  incurrence  of costs,  expenses,  losses or
         damages  of any kind  whatsoever  in  connection  with the  release  of
         Hazardous Substances;

                                       13
<PAGE>

                  (iii) Except as disclosed in Schedule 4.11 hereto, neither TPH
         nor any of its respective predecessors in interest, has used, produced,
         transported, stored, disposed, or caused to be transported to or stored
         or disposed at any  location,  including  but not limited to any Leased
         Property,  any Hazardous  Substance such that there may be an actual or
         potential  threat  of  release  to the  environment  of such  Hazardous
         Substance;

                  (iv) There are no  underground  storage  tanks,  impoundments,
         lagoons or similar facilities at any Leased Property or at any formerly
         leased  property  during the time of occupancy of such property by TPH,
         and any prior use and operation of aboveground storage tanks by TPH has
         been in  compliance  with all  Environmental  Laws and no  release  has
         occurred from any aboveground storage tank;

                  (v) TPH has  delivered  to Parent  true,  complete and correct
         copies  of  all  reports,  studies,  audits,  assessments,   manifests,
         analyses,  tests or monitoring in TPH's possession  relating to (i) the
         existence or potential  existence of Hazardous  Substances  at, and any
         other  environmental,  health or safety concerns  relating to, any real
         property  currently  or  formerly  owned,  leased,  operated,  used  or
         controlled by TPH or (ii) compliance with or liability under any of the
         Environmental  Laws  (collectively,  the "Reports"),  which Reports are
         listed on Schedule 4.11(b), and other than as set forth in the Reports,
         TPH  does  not  have  knowledge  of the  existence  or  release  of any
         Hazardous  Substances  on,  under,  from,  onto or at any real property
         currently or formerly owned,  leased,  operated,  used or controlled by
         TPH;

                  (vi)  TPH has  delivered  to  Parent  copies  of all  permits,
         licenses, approvals,  consents,  registrations and other authorizations
         necessary for the operation of the Leased  Property  ("Permits")  which
         permits are listed on Schedule 4.11(b), and TPH and the Leased Property
         have been and are in full compliance with the Permits. TPH has received
         no notice of  violation of any  Environmental  Law or Permit and to the
         knowledge of TPH, no notice of violation or review or revocation of any
         Permit is currently pending or threatened;

                  (vii) Neither TPH nor any of its  respective  predecessors  in
         interest,  has  expressly  assumed the liability of any other person or
         entity pursuant to any of the Environmental Laws; and

                  (viii)  Schedule  4.11(b)  contains  a  complete  list  of all
         Hazardous  Substances  used  or  stored  by TPH at  any  real  property
         currently or formerly owned,  leased,  operated,  used or controlled by
         TPH.

         (c) To the best of TPH's  knowledge,  the New  Jersey  Industrial  Site
         Recovery  Act does not  apply to TPH.  To the best of TPH's  knowledge,
         TPH's primary SIC Code is 8731 (Laboratory, Research & Development).

                                       14
<PAGE>

         (d) TPH  does not  generate  industrial  or  process  wastewaters.  The
         Company does not discharge  industrial or process  wastewaters into the
         public  sanitary  sewer  system or into an on-site  treatment or septic
         system.

         (e)  Except  as  set  forth  in  Schedule  4.11(e),  TPH's  storage  of
         flammable,  combustible,  and/or hazardous  substances does not require
         approval by any local, state or federal agency.

         (f) TPH is operating  under Permit No. BNSR  01-97-2243,  issued by the
         NJDEP on  September 5, 1997 (Air  Permit).  The Air Permit has not been
         amended. TPH does not operate any  emissions-producing  equipment which
         is not  authorized  by the Air Permit.  TPH is in  compliance  with all
         conditions of the Air Permit,  including but not limited to,  emissions
         limitations, recordkeeping, and submission of annual reports. NJDEP has
         not issued any notices of  non-compliance or notices of violations with
         respect to the Air Permit.

         (g) TPH does not generate regulated hazardous wastes.

         4.12.    CONFORMITY TO LAW.

         Except as set forth on Schedule  4.12  hereto,  TPH has complied in all
material  respects with, and is in compliance in all material respects with, all
laws,  statutes and governmental  regulations and all judicial or administrative
tribunal  orders,  judgments,  writs,  injunctions or decrees  applicable to its
business, other than those relating to Taxes and Environmental Law, except where
noncompliance  would not have an  adverse  effect on the  business,  operations,
assets, liabilities, condition (financial or otherwise) or prospects of the TPH,
considered as a whole.  Except as set forth on Schedule 4.12 hereto, TPH has not
been charged with any violation of any provision of any federal, state, local or
foreign law or  administrative  regulation  in respect of its  business,  except
where such a violation  would not an adverse effect on the business,  operations
or condition  (financial or otherwise) of TPH. All material statutory  municipal
and other licenses,  consents, permits and authorities other than those relating
to Taxes and Environmental Law necessary or desirable for the carrying on of the
business  and  activities  of TPH as now carried on have been  obtained  and are
valid and subsisting  and all conditions  thereof have been complied with in all
material  respects  and, to the  knowledge  of TPH none of them are likely to be
suspended, cancelled, revised, refused or revoked.

         4.13.    INSURANCE.

         Schedule  4.13 hereto lists all policies of fire,  liability,  worker's
compensation, life, property and casualty and other insurance and fidelity bonds
owned or held by TPH,  including summary  descriptions and the termination dates
thereof.  If TPH receives,  prior to the Closing,  any notice of cancellation or
other termination of any such policies  presently in effect,  TPH covenants that
it will use its best  efforts to  replace  such  policies  not later than a date
prior to the effective date of any such  cancellation or other  termination with
policies providing  substantially the same coverage. In respect of all the TPH's
insurance:  (i) all premiums  have been duly paid to date;  and (ii) no claim is
outstanding and to the knowledge of TPH, no circumstances exist which are likely
to give rise to any claim by or against TPH.

                                       15
<PAGE>

         4.14.    CONTRACTS.

         Except as listed or  described in Schedule  4.14  hereto,  TPH is not a
party  to or  bound  by any  agreements  or  other  legally  binding  contracts,
contractual   rights,   obligations   or   offers,   whether   written  or  oral
(collectively, "Contracts"), that are of the following types:

                  (i)  any  employment  or  consulting  agreement  that  is  not
         terminable at will by TPH (other than any agreement for the  employment
         of any such employee or former employee implied in law);

                  (ii) any collective bargaining agreement with any labor union;

                  (iii)  any   agreement   for  capital   expenditures   or  the
         acquisition or  construction  of fixed assets which requires  aggregate
         future payments in excess of $5,000;

                  (iv) any agreement  (other than in respect of Equipment Leases
         (as defined in clause  (ix) of this  Section  4.14)) for the  purchase,
         maintenance or  acquisition,  or the sale or furnishing,  of materials,
         supplies,   merchandise,   equipment  or  other  property  or  services
         (including   consulting   services)  which  requires  aggregate  future
         payments in excess of $50,000 and has a remaining term in excess of one
         year;

                  (v) any agreement  (other than any Equipment  Lease which is a
         finance lease) granting to any person a  first-refusal,  first-offer or
         similar  preferential  right to purchase or acquire any right, asset or
         property of TPH;

                  (vi) any material license or royalty agreement;

                  (vii) any indenture,  mortgage, loan or credit agreement under
         which TPH has borrowed any money or issued any note, bond, indenture or
         other  evidence of  indebtedness  for  borrowed  money,  or  guaranteed
         indebtedness for borrowed money of others;

                  (viii) any agreement with any manufacturer's representative or
         other  sales agent  having a  remaining  term in excess of one year and
         which is not terminable  without  penalty on thirty (30) calendar days'
         or shorter notice;

                  (ix) except for equipment  finance or operating leases entered
         into in the ordinary course of business ("Equipment Leases"), any lease
         under  which TPH is (i) a lessee of, or holds or uses,  any  machinery,
         equipment, vehicle or other tangible personal property owned by a third
         party or (ii) a lessor  of,  or makes  available  for use by any  third
         party, any tangible  personal  property owned by TPH, which in any such
         case requires aggregate annual payment in excess of $10,000;

                                       16

<PAGE>

                  (x)  any  Equipment  Lease   pertaining  to  equipment  which,
         individually  or together with other  equipment  that is the subject of
         such  Equipment  Lease,  had  an  aggregate  purchase  price  from  the
         manufacturer or distributor in excess of $50,000;

                  (xi) any factoring  arrangements,  hire purchase,  conditional
         sale or credit sale agreements affecting any of TPH's assets; or

                  (xii) any other agreement, not included under the terms of any
         other provision of this Section 4.14, which is not made in the ordinary
         course of  business or which  involves  future  payment or  performance
         valued in excess of $10,000 or which has a term of one year or more.

         (b) Except as set forth in Schedule 4.14 hereto,  each Contract  listed
or  described  therein is a valid and  binding  obligation  of TPH and, to TPH's
knowledge,  of each other party thereto and is in full force and effect.  Except
as set forth in  Schedule  4.14  hereto,  each  Contract to which TPH which is a
party and, to TPH's  knowledge,  each other  party  thereto  has  performed  all
material  obligations  required  to be  performed  by it through the date hereof
under the  Contracts  so listed and is not (with or without the lapse of time or
the  giving of notice,  or both) in  material  breach or default in any  respect
thereunder.

         (c) TPH does not have any outstanding powers of attorney except routine
powers  of  attorney  relating  to the  representation  of  such  Person  before
governmental  agencies  or given in  connection  with  qualification  to conduct
business or customs matters.

         (d) TPH has delivered to Parent a true and complete copy of each of the
written  Contracts  and a  description  of the terms and  conditions of any oral
Contracts.

         4.15.    EMPLOYEE BENEFIT PLANS.

         Schedule 4.15 hereto sets forth a true and complete list of all written
and oral, formal and informal,  annuity, bonus,  cafeteria,  stock option, stock
purchase,  stock appreciation or stock bonus profit sharing,  savings,  pension,
retirement,  incentive,  group  insurance,  insured or  self-insured  medical or
health and  hospitalization  or dental,  life or accident  disability,  employee
welfare, prepaid legal, nonqualified deferred compensation,  including,  without
limitation,  excess benefit plans and supplemental  executive  retirement plans,
top-hat plans,  deferred  bonuses,  rabbi trusts;  secular trusts,  nonqualified
annuity contracts,  insurance arrangements,  nonqualified stock options, phantom
stock plans,  severance,  voluntary  employee  beneficiary  association  (VEBA),
golden parachute payments,  tuition reimbursement or educational assistance,  or
vacation/time  off or other fringe  benefit plans.  TPH has no employee  benefit
funds or programs  (including  but not limited to such plans,  funds or programs
that are  "employee  benefit  plans"  within the meaning of Section  3(3) of the
Employee Retirement Income Security Act of 1974, as amended ("ERISA")), covering
employees  or  former  employees  of TPH (the  "Plans").  Except as set forth on
Schedule  4.15  hereto,   TPH  is  not  a  party  to  any  employee   agreement,
understanding, plan, policy, procedure or arrangements, whether written or oral,
which provides compensation or fringe benefits to its employees or which applies
to former employees of TPH, there are no negotiations,  demands,  commitments or
proposals  that are pending or that have been made to establish a plan providing
any benefits of a type  described in the  preceding  provisions  of this Section
4.15(a).  TPH does not  have  any  direct  or  indirect,  actual  or  contingent
liability for any Plan.

                                       17
<PAGE>

         4.16.    INTELLECTUAL PROPERTY RIGHTS.

         (a) Schedule  4.16 hereto sets forth a true and  complete  list of: (i)
all patents and applications  for patents,  all Marks (as defined in Article 11)
and  registrations  of Marks and  applications  for  registration of Marks,  all
copyright  registrations and applications for copyright  registrations and trade
names owned or used (pursuant to license agreements or otherwise) by TPH and, in
the case of any such  items of  Intellectual  Property  which are so owned,  the
jurisdictions in or by which such assets have been  registered,  filed or issued
and (ii) all contracts,  agreements or  understanding  pursuant to which TPH has
authorized any person to use any of the Intellectual  Property which is so owned
or under the terms of which TPH is authorized to use any  Intellectual  Property
or similar rights of any third party. TPH owns, possesses or licenses and, as of
the Closing Date, will own, possess or license, all right, title and interest in
and to the items of  Intellectual  Property which are material to the conduct of
its business as now  conducted or the business as  contemplated  in the Business
Plan for TPH appended  hereto as Exhibit E without  conflict  with the rights of
others.

         (b) Except as set forth in Schedule  4.16 hereto,  (i) TPH has the sole
and exclusive right to use the Intellectual Property (including applications for
any of the Intellectual Property) used in connection with its business, and none
of the past or present employees, officers, directors or shareholders of TPH, or
any other Person, has any rights with respect thereto,  (ii) the consummation of
the transactions  contemplated  hereby will not alter or impair any such rights,
(iii) TPH has not  received  any  notice or claim of  infringement  or any claim
challenging or questioning the validity or  effectiveness of any of the items of
Intellectual  Property, and there is no valid basis for any such claim, and (iv)
TPH is not liable, nor has any of them made any contract or arrangement  whereby
it may become liable,  to any Person for any royalty or other  compensation  for
use of any of the items of Intellectual Property.

         4.17.    INDEBTEDNESS.

         (a) Except for  Indebtedness  reflected or reserved against in the 1998
Balance Sheet or Indebtedness  incurred in the ordinary course of business after
the date of the 1998 Balance Sheet,  TPH has no Indebtedness  outstanding at the
date hereof, or will not have any Indebtedness  outstanding on the Closing Date.
Except as disclosed on Schedule 4.17 hereto,  TPH is not in default with respect
to any outstanding  Indebtedness or any instrument  relating thereto and no such
Indebtedness or any instrument or Agreement  relating  thereto purports to limit
the  operation  of the  business  by TPH.  Complete  and  correct  copies of all
instruments  (including  all  amendments,  supplements,  waivers  and  consents)
relating to any  Indebtedness  of TPH listed on  Schedule  4.17 hereto have been
furnished to Parent.

         (b)  Except as  disclosed  on  Schedule  4.17(b)  hereto,  there are no
outstanding loans by TPH to any of its  stockholders.  TPH has been (i) released
from all securities,  guarantees and indemnities given by or binding upon TPH in
relation to any debt or obligation of any of its stockholders  and/or of all and
any third parties and (ii) no such securities, guarantees or indemnities exists.

                                       18

<PAGE>

         4.18.    LABOR RELATIONS.

         TPH is in compliance in all material respects with all federal,  state,
local and foreign laws respecting employment and employment practices, terms and
conditions of employment,  wages and hours and  nondiscrimination  in employment
and is not  engaged in any unfair  labor  practice.  There is no charge or claim
pending or  threatened  against TPH alleging  unlawful  discrimination  or other
violation of law in employment  practices before any court or agency,  and there
is no charge or  complaint  of or  proceeding  with  regard to any unfair  labor
practice against TPH pending before the National Labor Relations Board. There is
not now, and at no time during the past five (5) years has there been, any labor
strike, dispute, slow-down or work stoppage or other job action actually pending
or, to, TPH's knowledge, threatened against or involving TPH other than disputes
with  individual  employees.  None of the  employees  of TPH is  covered  by any
collective  bargaining  agreement,  and no  collective  bargaining  agreement is
currently being negotiated by TPH. No questions  concerning  representation  has
been raised or, to TPH's  knowledge,  is threatened  respecting the employees of
TPH.

         4.19.    BROKERS.

         TPH has not  retained,  utilized or been  represented  by any broker or
finder in connection with the transactions contemplated by this Agreement.

         4.20.    ACCOUNTS RECEIVABLE AND ACCOUNTS PAYABLE.

         All accounts  receivable of TPH,  whether  reflected on the 1998 Fiscal
Year  End  Financial  Statements  or  otherwise,  represent,  or in the  case of
accounts receivable arising after the dates thereof and remaining outstanding at
the Closing Date will  represent,  sales actually made in the ordinary course of
business or valid claims as to which full  performance  has been  rendered.  The
reserves  against  such  accounts  receivable  for  returns  and bad  debts  are
commercially  reasonable and have been  determined in accordance  with generally
accepted accounting principles consistently applied; provided that such reserves
are  commercially  reasonable  based on the assumption  that the Acquisition sub
after the Closing  continues the collection  practices,  customer  relations and
product quality and performance standards of TPH prior to the Closing. Except to
the extent  reserved  against the  accounts  receivable,  no  counter-claims  or
offsetting  claims  with  respect  to the  accounts  receivable  are  pending or
threatened.  The accounts payable of TPH,  whether  reflected on the 1998 Fiscal
Year End Financial Statements or otherwise, arose from bona fide transactions in
the ordinary course of business,  and all such accounts  payable have been paid,
are not yet due and payable under the payer's  payment  policies and  procedures
(true and complete copies of which have been previously  provided to the Parent)
or are being contested by such payer in good faith.

                                       19

<PAGE>



         4.21.    INVENTORIES AND BACKLOG.

         Except as set forth on Schedule 4.21 hereto,  the  inventories  of TPH,
whether reflected on the 1998 Fiscal Year End Financial Statements or otherwise,
consist of raw materials, goods in process and finished goods saleable or usable
in the normal course of TPH's, business, and such inventories are not materially
excessive in kind or amount in light of such business.  All such inventories are
carried on the books of TPH pursuant to the normal inventory valuation policy of
TPH,  and are in  accordance  with  generally  accepted  accounting  principles,
consistently  applied,  as  reflected  in the 1998  Fiscal  Year  End  Financial
Statements.  Schedule 4.21 hereto sets forth the locations of all inventories of
TPH.  Except  as set  forth  on  Schedule  4.21  hereto,  no items  included  in
inventories  of TPH are or will be pledged as collateral or held by such Persons
on  consignment  from  others.  TPH is not,  nor on the Closing Date will it be,
committed to purchase  inventories  in amounts  greater than are required in the
ordinary  course  of  business.  With  respect  to  inventories  in the hands of
suppliers for which TPH will be committed on the Closing Date, such  inventories
on the Closing  Date will be  reasonably  expected to be usable in the  ordinary
course of business as presently being conducted.  As of May 3, 1999, the backlog
of firm  orders  for TPH was  $25,380.  Schedule  4.21  hereto  sets  forth  the
anticipated shipping dates for all backlog as of May 3, 1999.

         4.22.    EMPLOYEES.

         Schedule  4.22 hereto sets forth a complete  and  accurate  list of all
employees of each of TPH showing for each name, hire date,  current job title or
description,  bargaining  unit,  current  salary level  (including  any bonus or
deferred  compensation   arrangements)  and  any  bonus,   commission  or  other
remuneration paid during the most recently completed fiscal year, and describing
any existing contractual arrangement.

         4.23.    CUSTOMERS AND VENDORS.

         Schedule 4.23 hereto sets forth correct and complete lists of the three
(3) largest (by  consolidated  dollar volume)  customers and two (2) largest (by
consolidated  dollar  volume)  vendors  of TPH  during  the  two  most  recently
completed fiscal years,  indicating the existing  contractual  arrangements,  if
any,  with each such  customer or vendor.  Except as set forth on Schedule  4.23
hereto,  there are no  outstanding  disputes  with any customer or vendor listed
thereon,  and no  customer or vendor  listed  thereon  has  informed  TPH of its
intention  not to continue to do business  with TPH.  Since 1996,  there has not
been any material shortage or  unavailability of the raw materials  necessary to
manufacture  the  products  sold  by  TPH,  there  is  no  current  shortage  or
unavailability and, insofar as may be reasonably  foreseen,  no such shortage or
unavailability will occur.

         4.24.    DISTRIBUTORS AND REPRESENTATIVES.

         Schedule  4.24  hereto sets forth a correct  and  complete  list of the
twenty (20) largest distributors, representatives and agents for the sale of the
products  of TPH during the two most  recently  completed  fiscal  years and all
distributors,  representatives  and  agents to whom TPH has given any  exclusive
rights with respect to  territories or products.  Since 1993,  there has been no
termination of any independent distributor,  wholesaler, sales representative or
agent  relationship,  nor has any present independent  distributor,  wholesaler,
sales  representative  or agent  indicated  any present or future  intention  to
terminate or materially change the terms of its relationship with TPH.

                                       20

<PAGE>

         4.25.    PRODUCT WARRANTIES.

         Except with respect to matters  disclosed on Schedule 4.25, TPH has not
manufactured,  imported  sold or supplied  products  which are or were,  or will
become,  in any material respect faulty or defective or a danger to a purchaser,
a consumer or the public or any section of the public at large,  or which do not
comply in any material respect with any warranties or representations  expressly
or impliedly made by TPH, or in all material  respects with all applicable laws,
regulations,  standards and  requirements.  For the fiscal years ended March 31,
1995,  1996,  1997 and 1998 its, the liability of TPH for product  warranties or
guaranties, whether express or implied, has not exceeded in any such fiscal year
5% of  gross  sales.  True  and  correct  copies  of all  such  written  product
warranties and guaranties have been provided to Parent. The amounts reflected as
warranty  reserves  in  the  1998  Fiscal  Year  End  Financial  Statements  are
commercially  reasonable and have been  determined in accordance  with generally
accepted accounting principles, consistently applied.

         4.26.    ABSENCE OF QUESTIONABLE PAYMENTS.

         Neither TPH, nor any director, officer, agent, employee or other Person
acting on behalf of TPH, has (i) used any  corporate or other funds for unlawful
contributions,   payments,   gifts  or  entertainment,   or  made  any  unlawful
expenditures relating to political activity to government officials or others or
established  or  maintained  any  unlawful or  unrecorded  funds in violation of
Section 30A of the Exchange  Act or any other  applicable,  foreign,  federal or
state law,  (ii)  accepted or received  any  unlawful  contributions,  payments,
expenditures or gifts,  (iii) made any false or fictitious  entries in the books
and records of TPH, or (iv)

         4.27.    OFFICERS AND DIRECTORS; BANK ACCOUNTS.

         Schedule  4.27 hereto lists all officers and  directors of TPH, and all
of the bank accounts of TPH (designating each authorized signatory and the level
of each signatory's authorization).

         4.28.    TITLE TO ASSETS.

         Except as stated in the 1998 Fiscal Year End Financial Statements,  TPH
has good  title to all of the  assets  reflected  on the 1998  Balance  Sheet or
acquired  and used in TPH's  business  since  the date  thereof  and not sold or
otherwise  disposed of in the ordinary  course of business since such date, free
and  clear  of  all  liens,   title  defects,   mortgages,   charges,   pledges,
hypothecations,  security interests and encumbrances, provided that the forgoing
representation  and warranty  shall be construed in a manner which is consistent
with Section 4.7 above.

                                       21

<PAGE>



         4.29.    NO DISSENTING RIGHTS.

         In accordance with Section  14A:11-1(1)(a)(i)(B)  of the NJBCA, none of
the shareholders of TPH have the right to dissent from the Merger.

         4.30.    DISCLOSURE.

         No  representation,  warranty or statement  made by the Company in this
Agreement or in the Schedules or Exhibits  attached hereto,  contains any untrue
statement of a material  fact or omits to state a material  fact  required to be
stated herein or therein or necessary to make the statements contained herein or
therein not misleading.  The information or documents  provided by TPH to Parent
or its  representatives  in  connection  with the Merger and made  available  to
Purchaser,   considered  in  the  aggregate,   does  not  contain  any  material
misstatements  of fact or any material  omissions of fact  required to be stated
therein or necessary to make the statements  contained therein,  in light of the
circumstances under which they were made, not misleading.


                                    ARTICLE V

          REPRESENTATIONS AND WARRANTIES OF PARENT AND ACQUISITION SUB

         Parent and Acquisition Sub hereby represent and warrant to TPH, and TPH
in agreeing to consummate the  transactions  contemplated  by this Agreement has
relied upon such representations and warranties, that:

         5.1.     ORGANIZATION; GOOD STANDING.

         Parent is a corporation  duly  incorporated  and validly existing under
the laws of the Commonwealth of Massachusetts.  Acquisition Sub is a corporation
duly  incorporated,  validly existing and in good standing under the laws of the
State of Delaware.  Parent and Acquisition Sub are duly qualified to do business
and are in good standing in each  jurisdiction  in which the  properties  owned,
leased or operated by them or the nature of the business conducted by them makes
such  qualification  necessary,  except where  failure to be so qualified and in
good standing would not have a material adverse effect on the business of Parent
and Acquisition Sub, respectively.

         5.2.     POWER AND AUTHORITY.

         Each of  Parent  and  Acquisition  Sub has  full  corporate  power  and
authority to execute,  deliver and perform its obligations  under this Agreement
and all agreements and other documents executed and delivered, or to be executed
and  delivered,  by it  pursuant  to this  Agreement  and have  taken all action
required by its certificate of incorporation, by-laws or otherwise, to authorize
the  execution,  delivery  and  performance  of the  Agreement  and such related
documents  and the  consummation  of the  transactions  contemplated  hereby and
thereby.  The  execution  and  delivery of this  Agreement by each of Parent and
Acquisition Sub do not and, the  consummation of the Merger by each of them will
not  (i)  conflict  with  or  violate  any  provisions  of  its  certificate  of
incorporation  or by-laws,  or (ii)  constitute a breach of or default,  or give
rise,  with or  without  notice or lapse of time,  to any  third-party  right of
termination, cancellation, material modification or acceleration under any note,
bond,  mortgage,  pledge,  lien,  lease,  agreement,   license,   commitment  or
instrument,  applicable to Parent and Acquisition Sub, respectively, or conflict
with or violate  any  restrictions  of any kind to which any of them is subject,
and/or result in the creation of any lien, charge or other encumbrance or Tax on
or  against  any  assets,  rights or  property  of Parent and  Acquisition  Sub,
respectively.  This  Agreement  has been duly  executed and delivered by each of
Parent  and  Acquisition  Sub and  constitutes  the  legal,  valid  and  binding
obligations of Parent and Acquisition Sub, respectively enforceable against each
of them in accordance with its terms.

                                       22

<PAGE>

         5.3.     NON-CONTRAVENTION

         Neither the execution and delivery of this  Agreement by each of Parent
and Acquisition  Sub nor the  consummation by each of Parent and Acquisition Sub
of the transactions contemplated hereby will constitute a violation of, or be in
conflict  with,  or  constitute  or  create a  default  under,  or result in the
creation  or  imposition  of any  lien,  claim  or  encumbrance  upon any of its
property  pursuant to: (i) its certificate of incorporation  or bylaws,  each as
amended to date;  (ii) any  agreement or commitment to which it is a party or by
which it or its  properties is bound or any of such  properties  is subject,  or
(iii) any statute or any judgment, decree, order regulation or rule of any court
or governmental authority, except where any such violation,  conflict or default
would not have a material adverse effect on it,  considered as a whole, or would
not delay or prevent the Closing.

                                   ARTICLE VI

                   CONDUCT OF BUSINESS BY TPH PENDING CLOSING

         TPH agrees  with  Parent  and  Acquisition  Sub,  from the date of this
Agreement and until the Closing,  except as otherwise  specifically consented to
or approved by Parent in writing, as follows:

         6.1.     ACCESS.

         TPH  shall,  afford to Parent  and its  representatives  and  potential
providers of finance access,  during normal business hours to and make available
all  properties,   books,  records,  contracts  and  documents  of  TPH  and  an
opportunity to make such  investigations as they shall reasonably desire to make
of TPH and TPH  shall  furnish  or  cause  to be  furnished  to  Parent  and its
authorized  representatives all such information with respect to the affairs and
businesses of the TPH as Parent may  reasonably  request and make the employees,
auditors and attorneys of TPH available  for  consultation  and permit access to
other third parties reasonably  requested for verification of any information so
obtained.

         6.2.     CARRY ON IN REGULAR COURSE.

         TPH shall, maintain all of its Leasehold Property and personal property
in accordance with its historical  maintenance  practices and shall carry on its
business substantially in the same manner as conducted prior to the date hereof,
including,  without limitation,  by refraining from entering into any commitment
or  contract  or  engaging  in any  transaction  not in the  ordinary  course of
business and consistent with its normal business practices.

                                       23

<PAGE>

         6.3.     NO DIVIDENDS OR GENERAL INCREASES.

         TPH shall not make any  declaration,  setting  aside or  payment of any
dividend or any other  distributions  in respect of or other  equity  securities
except as  expressly  permitted  herein.  TPH shall  not,  grant any  general or
uniform  increase in the rates of pay of its employees,  or to grant any general
or uniform  increase in the  benefits  under any bonus or pension  plan or other
contract or commitment unless such grant or increase is required by the terms of
any existing  agreement;  nor shall it increase the  compensation  payable or to
become payable to the officers, key salaried employees or agents, or to increase
any bonus, insurance, pension or other benefit plan, payment or arrangement made
to, for or with any such officers, key salaried employees or agents.

         6.4.     SALES OF CAPITAL ASSETS.

         TPH shall not, sell or otherwise dispose of any capital asset in excess
of $5,000 or other than in the ordinary  course of business  consistent with its
normal business practices.

         6.5.     PRESERVATION OF ORGANIZATION.

         TPH shall,  use all  reasonable  efforts to  preserve  intact  business
organization  and to  preserve  for Parent its  present  relationships  with its
supplies and customers and others having business relationships with TPH.

         6.6      PRESERVATION OF REORGANIZATION.

         TPH  shall  not  take or  cause  to be taken  any  action  which  would
disqualify  the Merger as a tax free  reorganization  under  Section  368 of the
Code.

         6.7.     NO AMENDMENTS TO CHARTER.

         TPH shall not amend its Certificate of Incorporation or Bylaws.

         6.8.     ISSUANCE OF CAPITAL STOCK.

         Except as  expressly  permitted  herein,  TPH shall not issue,  sell or
grant options, warrants or rights to purchase or subscribe to, or enter into any
arrangement  or  contract  with  respect to the  issuance or sale of, any of its
capital stock or rights or obligations  convertible into or exchangeable for any
shares of its  capital  stock or make any  changes  (by  split-up,  combination,
reorganization or otherwise) in its capital structure.

                                       24

<PAGE>



         6.9.     ACQUISITIONS.

         TPH shall not acquire or enter into an agreement to acquire, by merger,
consolidation or purchase of stock or assets, any business or entity.

         6.10.    TRANSACTIONS WITH AFFILIATES.

         TPH shall not engage in any transaction with its officers, directors or
shareholders, or any person with whom any such shareholder,  officer or director
has any direct or indirect  relation  by blood,  marriage  or  adoption,  or any
entity in which any of such persons owns any beneficial  interest  (other than a
publicly-held  corporation  whose  stock  is  traded  on a  national  securities
exchange  or in the  over-the-counter  market  and less  than 1% of the stock of
which is beneficially owned by all such persons).

         6.11.    MATERIAL CONTRACTS.

         TPH shall perform in all material respects all of its obligations under
all Contracts  (except those being  contested in good faith) and not enter into,
assume or amend any contract or commitment that would be a Contract,  other than
a Contract  entered into in the ordinary  course of business and consistent with
past practice and involving payments aggregating no more than $5,000.

         6.12.    INSURANCE.

         TPH shall use its best efforts to maintain in full force and effect and
in the same  amounts  policies of  insurance  comparable  in amount and scope of
coverage  to that it now  maintains  and not amend or  cancel  any  policies  of
insurance it now maintains.

         6.13.    ACCOUNTING PRACTICES.

         TPH shall not permit a change in its methods of maintaining  its books,
accounts  or  business  records  or,  except as required by GAAP (in which event
prior notice shall be given to Parent),  change any of its accounting principles
or the  methods  by which  such  principles  are  applied  for tax or  financial
reporting purposes.

         6.14.    TAXES.

         TPH shall  prepare  and file all  federal,  state,  local  and  foreign
returns for taxes and other tax reports, filings and amendments thereto required
to be filed by it,  on a timely  basis  and in a  manner  consistent  with  past
practice.

         6.15.    TERMINATION.

         TPH  shall  not  unless  and  until  this  Agreement  shall  have  been
terminated  by the parties  hereto in accordance  with Article XIV hereof,  (and
shall use reasonable  efforts to cause its affiliates,  officers,  directors and
employees  and any  investment  banker,  attorney,  accountant  or  other  agent
retained by it or its affiliates  not to): (i) initiate or solicit,  directly or
indirectly, any Acquisition Proposal; (ii) initiate, directly or indirectly, any
contact  with any person in an effort to or with a view towards  soliciting  any
Acquisition  Proposal;   (iii)  furnish  information  concerning  its  business,
properties or assets to any corporation,  partnership, person or other entity or
group (other than Parent, Acquisition Sub or any affiliate,  associate, agent or
representative of Parent or Acquisition Sub) under any circumstances  that could
reasonably be expected to relate to an actual or potential Acquisition Proposal;
or (iv) negotiate or enter into  discussions,  directly or indirectly,  with any
entity or group with respect to any actual or potential Acquisition Proposal. In
the event that TPH shall  receive or become  aware of any  Acquisition  Proposal
subsequent to the date hereof,  TPH shall promptly  inform Parent as to any such
matter and the details  thereof and shall convey to Parent a copy of any letter,
proposal or other document in which any such Acquisition Proposal is expressed.

                                       25
<PAGE>

         6.16.    OTHER.

         TPH shall not (i) borrow any money,  (ii)  create any fixed or floating
charge,  lien or other  encumbrance  over any part of its  properties or assets,
(iii)  make any loan to any  person  or (iv)  guarantee  or the  liabilities  or
obligations of any person. TPH shall immediately notify Parent of the occurrence
of any extraordinary event adversely affecting TPH.


                                   ARTICLE VII

                  CONDUCT OF BUSINESS BY PARENT PENDING CLOSING

         Parent agrees with TPH,  from the date of this  Agreement and until the
Closing,  except as  otherwise  specifically  consented to or approved by TPH in
writing, as follows:

         7.1.     ACCESS.

         Upon  reasonable  notice and subject to applicable laws relating to the
exchange of information including,  but not limited to, federal securities laws,
Parent shall afford to TPH and its  representatives  and potential  providers of
finance  access,  during  normal  business  hours  to  and  make  available  all
properties, books, records, contracts and documents of Parent and an opportunity
to make such  investigations  as they shall reasonably  desire to make of Parent
and  shall  furnish  or  cause  to  be  furnished  to  TPH  and  its  authorized
representatives  all such information with respect to the affairs and businesses
of Parent as TPH may  reasonably  request and make the  employees,  auditors and
attorneys of Parent  available for consultation and permit access to other third
parties reasonably requested for verification of any information so obtained.

         7.2.     PRESERVATION OF REORGANIZATION.

         Parent  shall  not take or cause to be taken  any  action  which  would
disqualify  the Merger as a tax free  reorganization  under  Section  368 of the
Code.

                                       26


<PAGE>



                                  ARTICLE VIII

       CONDITIONS PRECEDENT TO PARENT'S AND ACQUISITION SUB'S OBLIGATIONS

         The obligations of Parent and Acquisition Sub, including the obligation
of Acquisition Sub to consummate the transactions  contemplated  hereby shall be
subject to the  satisfaction at or prior to the Closing of each of the following
conditions (to the extent noncompliance is not waived in writing by Parent).

         8.1.     REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING.

         The  representations  and  warranties  made  or  given  by TPH in  this
Agreement  shall be true and correct at and as of the Closing Date with the same
effect as though such  representations  and warranties had been made or given at
and as of the Closing Date.

         8.2.     COMPLIANCE WITH AGREEMENT.

         TPH shall have performed and complied with all of its obligations under
this Agreement to be performed or complied with by it on or prior to the Closing
Date.

         8.3.     OFFICER'S CERTIFICATE.

         TPH shall have  delivered  to  Acquirer  in  writing,  at and as of the
Closing, a certificate duly executed by an executive officer of TPH,  certifying
that the conditions in each of Sections 8.1 and 8.2 have been satisfied.

         8.4.     NO INJUNCTION.

         No injunction  shall have been obtained,  and no suit,  action or other
proceeding  shall be pending  or  threatened  before  any court or  governmental
entity in which it is sought to restrain or prohibit or in the reasonable belief
of the Board of Directors of Parent,  materially  modify the consummation of the
transactions  contemplated hereby, or involving a claim that the consummation of
the  transactions  contemplated  hereby  would result in a violation of any law,
decree or regulation of any government entity.

         8.5.     RESIGNATION OF DIRECTORS.

         Parent shall have received the resignation of all directors of TPH.

         8.6.     NO MATERIAL ADVERSE CHANGE.

         During the period from the date hereof through the Closing Date,  there
shall not have been any material  adverse  change in the  business,  operations,
properties, assets, liabilities, condition (financial or otherwise) or prospects
of the members of the TPH, individually or taken as a whole.

         8.7.     CORPORATE PROCEEDINGS.

                                       27
<PAGE>

         All corporate and other  proceedings to be taken and all consents to be
obtained in connection with the  transactions  contemplated by this Agreement by
TPH and all documents incident thereto shall be reasonably  satisfactory in form
and  substance  to Parent  and its  counsel,  who shall have  received  all such
originals  or  certified  or  other  copies  of such  documents  as  either  may
reasonably request.

         8.8.     CONSENTS.

         Except  for the  filing of the New  Jersey  Certificate  of Merger  and
Delaware  Certificate of Merger  described in Section 1.5, there shall have been
received all necessary  governmental and contractual  consents or authorizations
required in connection with the transactions contemplated hereby.

         8.9.     TPH STOCKHOLDER APPROVAL.

         This Agreement shall have been approved by the stockholders of TPH.

         8.10.    EMPLOYEES.

         Parent  shall have made  arrangements  satisfactory  to it with current
executive  and  managerial  employees  of the  members  of TPH  regarding  their
employment after the Closing.  Without limiting the generality of the foregoing,
James Knox and Ms.  Jirina  Kuzma  shall  have  entered  into a  non-competition
agreement and confidentiality agreement, in form mutually satisfactory to Parent
and each of them and such agreements shall be in force and effect.

         8.11.    DUE DILIGENCE.

         Parent  shall have  completed  and been  satisfied in good faith in its
sole  discretion  with the  results  of a due  diligence  review  of TPH and its
businesses,  operations,  properties, assets, liabilities,  condition (financial
and otherwise) and prospects, with its due diligence review of the environmental
condition of properties  owned or occupied by TPH and the  compliance  status of
TPH's  operations,  and with its due  diligence  investigation  of the financial
projections   and  Tax   Returns   previously   provided   to   Parent   or  its
representatives.

         8.12.    OPINION OF COUNSEL.

         NKNRET,  counsel  to TPH,  shall  have  delivered  to  Parent a written
opinion,  addressed to Parent and  Acquisition  Sub and dated the Closing  Date,
substantially in the form of Exhibit F hereto.

         8.13.    SECTION 3.2 DELIVERIES.

         All  deliveries  to be made by  stockholders  of TPH under  Section 3.2
shall have been made.

                                       28
<PAGE>

         8.14.    ESCROW AGREEMENT.

         Each of TPH,  any  representative  of the  stockholders  of TPH and the
Escrow Agent shall have  executed and delivered  the Escrow  Agreement,  and the
Escrow Agreement shall be in full force and effect.

         8.15.    QUESTIONNAIRES.

         Parent   shall  have   received   properly   completed   and   executed
questionnaires,  in form  satisfactory to Parent,  from every stockholder of TPH
(or such  lesser  number of  stockholders  as  Parent,  in its good  faith  sole
discretion,  deems sufficient), in which such stockholders indicate whether they
are an "Accredited Investor" as that term is defined in Rule 501 of Regulation D
promulgated  under the  Securities  Act of 1933, as amended  ("Securities  Act")
thereunder. Parent in its good faith discretion shall be satisfied, based on its
review of such completed and executed  Questionnaires,  that the issuance of the
Stock   Consideration  is  exempt  under  Regulation  D  promulgated  under  the
Securities Act from the federal securities registration requirements.

         8.16     CONSENT TO ASSIGNMENT.

         Parent  shall have  received  the consent of Helene  Curtis,  Inc.  and
AorTech Europe Limited to the assignment of their contracts to Acquisition  Sub,
in form satisfactory to Parent.

         8.17     EXERCISE OF OPTIONS.

         With  respect to the  options  held by Murray  Reich and  Jirina  Kuzma
disclosed on Schedule 4.4, TPH and such optionees  shall deliver a letter signed
by TPH and such optionees that such options have been terminated.

         8.18     SECTION 4.17 INDEBTEDNESS

         TPH shall  discharge all debt listed on Schedule 4.17,  including,  but
not limited to, its $40,000  debt to Helene  Curtis for  Equipment as defined in
the Agreement between TPH and Helene Curtis effective February 1, 1997.

         8.19     SECTION 4.11(b) PERMITS

         TPH shall have filed  with  NJDEP the  annual  registration  statements
described on Schedule 4.11(b).

                                       29


<PAGE>


         8.20     SIC CODE

         TPH  shall  ensure  that  its  primary  SIC  Code is 8731  (Laboratory,
Research &  Development)  or such other  primary SIC Code as agreed to by Parent
and TPH.


                                   ARTICLE IX

                    CONDITIONS PRECEDENT TO TPH'S OBLIGATIONS

         The  obligations  of TPH to consummate  the  transactions  contemplated
hereby shall be subject to the satisfaction, at or prior to the Closing, of each
of the  following  conditions  (to the  extent  noncompliance  is not  waived in
writing by TPH, if available):

         9.1.     REPRESENTATIONS AND WARRANTIES TRUE AT CLOSING.

         The  representations  and warranties made by Parent and Acquisition Sub
in this  Agreement  shall be true at and as of the  Closing  Date  with the same
effect as though made or given at and as of the Closing Date.

         9.2.     COMPLIANCE WITH AGREEMENT.

         Parent and  Acquisition  Sub shall have performed and complied with all
of their respective obligations under this Agreement that are to be performed or
complied with by them at or prior to the Closing.

         9.3.     OFFICER'S CERTIFICATE.

         Parent  shall  have  delivered  to  TPH  in  writing,  at and as of the
Closing,  a certificate duly executed by an executive  officer of Parent, to the
effect that the conditions in each of Section 9.1 and 9.2 have been satisfied.

         9.4.     CONSENTS.

         Except  for the  filing of the New  Jersey  Certificate  of merger  and
Delaware  Certificate of merger  described in Section 1.5, there shall have been
received  all  necessary  governmental  consents or  authorizations  required in
connection with the transactions contemplated hereby.

         9.5.     CORPORATE PROCEEDINGS.

         All corporate and other  proceedings to be taken and all consents to be
obtained  by Parent and  Acquisition  Sub in  connection  with the  transactions
contemplated  by this  Agreement  and all  documents  incident  thereto shall be
reasonably  satisfactory in form and substance to TPH and its counsel, who shall
have received all such  originals or certified or other copies of such documents
as either may reasonably request.

                                       30

<PAGE>



         9.6.     ESCROW AGREEMENT.

         Each of Parent, any  representatives of the stockholders of TPH and the
Escrow Agent shall have  executed and delivered  the Escrow  Agreement,  and the
Escrow Agreement shall be in full force and effect.


                                    ARTICLE X

                      CERTAIN UNDERSTANDINGS AND AGREEMENTS

         10.1.    REGISTRATION OF SHARES.

         Parent agrees and covenants to use its commercially  reasonable efforts
to register for resale under the Securities Act on Form S-3,  within ninety (90)
days of the  Effective  Time  the  shares  of its  Common  Stock  issued  to the
stockholders  of TPH  pursuant  to the  Merger  (or if the  Company  is not then
eligible  to register  for resale  such shares of Common  Stock on Form S-3 such
registration shall be on another appropriate form).

         10.2.    SHAREHOLDER MEETING.

         TPH shall  take all steps  necessary  to duly  call,  give  notice  of,
convene  and hold a special  meeting of its  shareholders  to be held as soon as
possible  after the date hereof for the  purpose of voting upon the  approval of
this Agreement and the consummation of the transactions contemplated hereby. The
Board of Directors of TPH hereby does and  (subject to the  fiduciary  duties of
TPH's Board of Directors,  as advised by outside  counsel to TPH) will recommend
that  shareholders  of TPH vote to approve this Agreement and the Merger and the
other  transactions  contemplated  hereby and  (subject to such duties) will use
best  efforts  to obtain  any vote of such  shareholders  that is  necessary  to
authorize the Merger and such  transactions.  TPH shall coordinate and cooperate
with  Parent  with  respect  to the  scheduling  of the  special  meeting of its
shareholders  and will not take any action to delay,  postpone  or  adjourn  the
special meeting without the prior written consent of Parent.

         10.3.    SUBSEQUENT FINANCIAL STATEMENTS.

         Parent will deliver to TPH simultaneously  with its filing thereof with
the SEC any  Quarterly  or  Annual  Report  of  Parent  on  Form  10-Q or  10-K,
respectively,  filed by Parent with the SEC under the  Exchange  Act between the
date hereof and the Effective Time.

         10.4.    ADDITIONAL AGREEMENTS.

         In case at any time  after the  Effective  Time any  further  action is
necessary or  desirable  to carry out the purposes of this  Agreement or to vest
the Surviving  Corporation  with full title to all properties,  assets,  rights,
approvals,  immunities and franchises of TPH, the proper  officers and directors
of TPH shall take all such  necessary  action as may be reasonably  requested by
Parent.

                                       31

<PAGE>



         10.5.    ADVICE OF CHANGES, FAILURE OF CONDITIONS.

         Each of Parent and TPH shall  promptly  advise  the other  party of any
change or event which it believes has caused or  constitutes,  or is  reasonably
likely to cause or constitute,  a material breach of any of its representations,
warranties or covenants  contained  herein or is reasonably  likely to cause any
condition hereunder to the other party's obligation to consummate the Merger not
to be satisfied.  From time to time prior to the Effective  Time (and on the day
prior to the  Closing),  each  party  will  promptly  supplement  or  amend  the
Schedules  delivered by it in connection with the execution of this Agreement to
reflect any matter  that,  if  existing,  occurring or known at the date of this
Agreement,  would  have  been  required  to be set  forth or  described  in such
Schedules  or that is  necessary to correct any  information  in such  Schedules
which has been rendered inaccurate thereby.


                                   ARTICLE XI

                               CERTAIN DEFINITIONS

         As used  herein the  following  terms not  otherwise  defined  have the
following respective meanings:

         "Acquisition Proposal" means any proposal, plan or offer to acquire all
or any such  substantial  part of the business or properties or capital stock of
TPH,  whether by merger,  purchase of assets,  tender offer or otherwise,  or to
liquidate  TPH  or  otherwise  distribute  to  shareholders  of  TPH  all or any
substantial part of the business or properties of TPH; provided,  however,  that
the Merger shall not  constitute  an  Acquisition  Proposal for purposes of this
Agreement.

         "GAAP" means  generally  accepted  accounting  principles of the United
States applied in a manner consistent with past practices.

         "Indebtedness" means all obligations,  contingent or otherwise, that in
accordance  with GAAP should be classified  upon the obligor's  balance sheet as
liabilities, or to which reference should be made in the footnotes thereto.

         "Intellectual   Property"  includes  any  and  all  inventions,   Marks
(including trademarks, service marks, certification marks, collective marks, and
collective membership marks, whether word, logo, or other forms of Marks, all of
the  foregoing  collective  referred to as "Marks"),  trade  names,  copyrights,
applications  therefor,  patents  thereon,  registrations  thereof and  licenses
thereof,  royalty rights,  any and all goodwill  associated with the business or
represented  by the assets of such party,  trade secrets,  secret  processes and
procedures,   engineering,   production,   assembly   design  and   installation
encompassed in any and all embodiments including,  but not limited to, technical
drawings  and   specifications,   working  notes  and  memos,   market  studies,
consultants'  reports of technical and  laboratory  data,  competitive  samples,
engineering prototypes and confidential  information,  know-how, and all similar
property of any nature, tangible or intangible.

                                       32
<PAGE>

         "Marks"  has the meaning set forth in the  definition  of  Intellectual
Property.

         "Person"  means and includes an individual,  a  partnership,  a limited
liability  partnership,  a joint  venture,  a corporation,  a limited  liability
company,  a trust, an  unincorporated  organization,  a group or a government or
other department or agency thereof.


                                   ARTICLE XII

                            CONFIDENTIAL INFORMATION

         Any and all information  disclosed by Parent to TPH or by TPH to Parent
as a result of or in connection with the  negotiations  leading to the execution
of this Agreement,  or in furtherance thereof, which information was not already
known to TPH or to Parent, as the case may be, shall be kept confidential by TPH
and by Parent and their respective  employees and agents until the Closing Date,
except to the extent that Parent in its  reasonable  judgment  must disclose any
such  information to potential  providers of finance in the process of procuring
financing  for the purchase  contemplated  herein.  If the Closing does not take
place for any reason,  each of TPH and Parent  agrees not to further  divulge or
disclose or use for its benefit or purposes any such  information at any time in
the future unless it has otherwise become public. The information intended to be
protected hereby shall include,  but not be limited to,  financial  information,
customers,  sales  representatives,  and  anything  else  having an  economic or
pecuniary benefit to TPH or Parent, respectively. Notwithstanding the foregoing,
TPH  may  disclose  to  its  stockholders  and  affiliated  parties  information
necessary  or  desirable  in order  to  properly  inform  its  stockholders  and
affiliated   parties  for  the  purposes  of  taking  a   stockholder   vote  on
authorization of the Merger.

                                       33
<PAGE>

                                  ARTICLE XIII

                                 INDEMNIFICATION

         13.1.    INDEMNIFICATION.

         Subject to the limitations  hereinafter set forth, Parent,  Acquisition
Sub,  each of  their  respective  officers,  directors,  employees,  agents  and
representatives and their respective successors and assigns shall be indemnified
and  held  harmless  from,  against  and in  respect  of  any  and  all  losses,
liabilities,   deficiencies,  penalties,  fines,  costs,  damages  and  expenses
whenever arising or incurred  (including,  without  limitation,  amounts paid in
settlement and costs of investigation) ("Losses" and singularly "Loss") that may
be suffered or incurred by any of them  arising  from or by reason of any of the
following:  (i) breach of any  representation  or  warranty  made by TPH in this
Agreement  or (ii) any and all actions,  suits,  proceedings,  claims,  demands,
assessments,  judgments,  costs and  expenses  (including,  without  limitation,
interest, penalties,  reasonable legal fees and accounting fees) incident to the
foregoing and the  enforcement  of the  provisions  of this Section.  Claims for
Losses may only be made  against the  Escrowed  Funds and no  recourse  shall be
available  against any  stockholder or former  stockholder of TPH or against any
other  portion of the  Merger  Consideration,  except if and to the extent  such
stockholder or former  stockholder shall have entered into a separate  agreement
providing otherwise.

         13.2.    CLAIMS.

         (a)  Notice.   Any  party  seeking   indemnification   hereunder   (the
"Indemnified  Party") shall promptly notify the other party hereto  obligated to
provide indemnification  hereunder (the "Indemnifying Party") of the any action,
suit,  proceeding,  demand or  breach  (a  "Claim")  with  respect  to which the
Indemnified Party claims indemnification hereunder; provided that failure of the
Indemnified  Party to give such notice shall not relieve any Indemnifying  Party
of its obligations under this Article XIII except to the extent, if at all, that
such Indemnifying Party shall have been materially prejudiced thereby.

         (b) Third Party  Claims.  If such Claim  relates to any  action,  suit,
proceeding or demand  instituted  against the Indemnified Party by a third party
(a "Third Party Claim"),  the Indemnifying Party shall be entitled to assume the
defense  of such  Third  Party  Claim  against  such  claimant  (a "Third  Party
Claimant")  after receipt of such notice from the Indemnified  Party, and in the
case of such an assumption  the  Indemnifying  Party shall have the authority to
negotiate, compromise and settle such Third Party Claim.

         The Indemnified  Party shall retain the right to employ its own counsel
and to participate in the defense of any Third Party Claim, the defense of which
has been assumed by the Indemnifying  Party, in which case the Indemnified Party
shall bear and shall be solely  responsible  for its own costs and  expenses  in
connection with such  participation.  If the Indemnifying  Party does not assume
the  defense  of any  Third  Party  Claim  as  provided  in  this  Section,  the
Indemnified  Party may defend the Third Party Claim as it determines in its sole
discretion at the expense and risk of the Indemnifying Party.

                                       34
<PAGE>

         Notwithstanding  the  foregoing  provisions  of  this  Section,  (i) no
Indemnifying Party shall be entitled to settle any Third Party Claim without the
Indemnified  Party's prior written consent unless as part of such settlement the
Indemnified Party is released in writing from all liability with respect to such
Third Party Claim and (ii) no Indemnified  Party shall be entitled to settle any
Third Party Claim without the Indemnifying  Party's prior written consent unless
as part of such settlement the Indemnifying Party is released by the Indemnified
Party and the Third Party Claimant in writing from all liability  (including all
liability  under this  Article  XIII) with  respect to such Third  Party  Claim.
Further,  neither  shall settle any Third Party Claim  without the other's prior
written  consent if the terms of the settlement  would involve any limitation on
the future activities of the other.

         13.3.    METHOD AND MANNER OF PAYING CLAIMS.

         Subject to the  Indemnifying  Party's right pursuant to Section 13.2 to
defend and settle a Third Party Claim, payment of any amount required to be paid
to Parent under this Article  XIII shall be made  exclusively  from the Escrowed
Funds.  The unpaid  balance of a Claim that has not been paid within  forty-five
(45) days of written demand therefor shall bear interest at the weighted average
rate of  interest  actually  earned by the  Escrowed  Funds from the date notice
thereof is given by the Indemnified  Party to the Indemnifying  Party;  provided
that the  Indemnifying  Party shall only be  obligated  to pay  interest on that
portion of such Claim ultimately determined to be owed to the Indemnified Party.

         13.4.    LIMITS ON INDEMNIFICATION.

         (a) The amount of any Losses  receivable  hereunder shall be reduced by
the net amount the Indemnified  Party recovers  (after  deducting all attorneys'
fees,  expenses  and other  costs of  recovery)  from any insurer or other third
party  liable for such  Losses.  To the extent  that the  Indemnified  Party has
already received  payment from the  Indemnifying  Party with respect to any Loss
and the  Indemnified  Party later  recovers any amounts from an insurer or third
party with  respect to such  Losses,  the  Indemnified  Party shall  refund such
amounts to the Indemnifying Party.

         (b) No Indemnified Party shall be entitled to indemnification hereunder
with  respect  to  (i)  frivolous  claims,  suits,  actions  or  proceedings  as
determined  by a court of  competent  jurisdiction  or arbitral  body or (ii) an
indemnifiable  claim or claims  unless the  aggregate  amount of Losses  exceeds
$5,000, in which event the indemnity  provided for in this Article XIII shall be
effective  with  respect to only such amount as exceeds  $5,000,  subject to the
limitation on the maximum amount of $100,000.

         (c) No  Indemnifying  Party shall be liable for any Losses  pursuant to
this Article XIII unless a written claim for  indemnification in accordance with
Section 13.2 is given by the Indemnified  Party to the  Indemnifying  Party with
respect  thereto by thirty  (30) days after the first  anniversary  date of this
Agreement.

                                       35
<PAGE>

         13.5.    SURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS.

         All  representations and warranties of TPH, set forth in this Agreement
or any other agreement,  instrument,  certificate or other document executed and
delivered by TPH in  connection  with this  Agreement  (and any  indemnification
obligation with respect  thereto) shall survive any  investigation  by Parent at
and as of  the  Closing  Date  and  shall  terminate  and  expire  on the  first
anniversary  date of this  Agreement;  provided that, if Parent or the Surviving
Corporation shall have asserted a bona fide claim in writing for indemnification
hereunder  not later than thirty (30) days after the first  anniversary  date of
this Agreement,  the  representations  or warranties alleged in such claim to be
breached shall survive until such claim is resolved.


                                   ARTICLE XIV

                               RIGHT TO TERMINATE

         In the event that the Closing  does not occur on or before 60 days from
the date of this Agreement, either Parent or TPH may terminate this Agreement at
any time after the close of business on such date by delivering  written  notice
to the  other so long as such  failure  to close was not a result of a breach by
the  party  seeking  to  terminate  this  Agreement.  In the  event  of any such
termination,  this  Agreement  shall  forthwith  become  void and of no  effect,
without  liability or  obligation  on the part of any party hereto except to the
extent that such  termination  shall have resulted from the willful and material
breach  by a  party  of any of its  representations,  warranties,  covenants  or
agreements set forth in this Agreement.


                                   ARTICLE XV

                                     GENERAL

         15.1.    EXPENSES.

         (a) All costs and expenses incurred in connection with the negotiation,
preparation,  execution  and  performance  of this  Agreement  and  all  related
agreements  and  other  documents  shall be borne by the  party  incurring  such
expenses.

         (b) If any action, suit,  arbitration proceeding or other proceeding is
instituted arising out of this Agreement, the prevailing party, in proportion to
the degree to which such party  prevails,  shall  recover  such  party's  costs,
including,  without limitation,  the court or arbitral costs (including fees and
expenses  payable to any  arbitrator  or the AAA (as defined in Section 15.7) in
connection  with any such  arbitration)  and attorneys'  fees incurred  therein,
including any and all appeals or petitions therefrom.

         15.2.    NONSURVIVAL OF REPRESENTATIONS, WARRANTIES AND AGREEMENTS.

         None of the  representations,  warranties,  covenants and agreements of
Parent and/or  Acquisition  Sub in this Agreement nor any  instrument  delivered
pursuant  to this  Agreement  or in any  instrument  delivered  pursuant to this
Agreement  shall  survive the  Effective  Time,  except for those  covenants and
agreements  contained  herein and therein which by their terms apply in whole or
in part after the Effective Time.

                                       36
<PAGE>

         15.3.    NOTICES.

         All notices,  demands and other  communications  hereunder  shall be in
writing or by written  telecommunication,  and shall be deemed to have been duly
given if delivered  personally or by overnight courier or if mailed by certified
mail,   return  receipt   requested,   postage  prepaid,   or  sent  by  written
telecommunication, as follows:

         If to TPH prior to the Closing or to the  stockholders of TPH after the
Closing, to:

         Murray H. Reich
         184 Loomis Court
         Princeton, NJ 08540

         with a copies sent simultaneously to:

         Howard Nashel, Esquire
         Nashel Kates Nussman Rapone Ellis & Traum, LLP
         190 Moore Street
         Suite 360
         Hackensack, NJ  07601-7407

         If to Parent, or Acquisition Sub, to:

         CardioTech International, Inc.
         78E Olympia Avenue
         Woburn, MA 01801
         Attention: President
         Fax: 781-933-3933

         with copies sent simultaneously to:

         Michael L. Fantozzi, Esquire
         Mintz, Levin, Cohn, Ferris, Glovsky
           and Popeo, P.C.
         One Financial Center
         Boston MA 02111
         Fax:  617-542-2241

         Any such notice shall be effective  (i) if delivered  personally,  when
received;  (ii) if sent by  overnight  courier,  when  receipted  for;  (iii) if
mailed,  three days after being mailed as described  above,  and (iv) if sent by
facsimile transmission,  when dispatched, on the condition that the transmission
is confirmed.

                                       37
<PAGE>

         15.4.    ENTIRE AGREEMENT.

         This Agreement  contains the entire  understanding of the parties as to
the subject matter hereof,  supersedes all prior or  contemporaneous  agreements
and  understandings  relating  to the  subject  matter  hereof  and shall not be
amended except by a written  instrument  hereafter  signed by all of the parties
hereto.

         15.5.    GOVERNING LAW.

         The  validity,  interpretation,   validity  and  construction  of  this
Agreement  shall be governed by the  internal  laws,  but not the  choice-of-law
rules of the Commonwealth of Massachusetts.

         15.6.    CONSENT TO JURISDICTION.

         Each  of  the  parties   hereby  agrees  to  submit  to  the  exclusive
jurisdiction  of the courts in and of the  Commonwealth  of  Massachusetts,  and
consents  that  service  of  process  with  respect  to all courts in and of the
Commonwealth of Massachusetts may be made to them at their respective  addresses
set forth in Section 15.3 in the manner set forth therein.

         15.7.    ARBITRATION.

         (a) All disputes  arising in connection  with this Agreement other than
matters pertaining to injunctive relief, shall be finally settled by arbitration
in accordance with the provisions herein.

         (b) Any party which desires to initiate arbitration  proceedings may do
so by delivering written notice to the other parties (the "Arbitration Notice"),
specifying  the nature of the dispute or  controversy  to be arbitrated and such
other  matters as may be required by the Rules of  Arbitration  of the  American
Arbitration  Association (the "AAA"). The parties shall in good faith attempt to
select an arbitrator agreeable to both parties.

         (c) If within  thirty (30) days of receipt of the  Arbitration  Notice,
the parties cannot  mutually  agree on the selection of an arbitrator,  then the
dispute which is the subject of such notice shall be  arbitrated  before the AAA
in the Commonwealth of Massachusetts by a panel of three arbitrators selected to
the extent provided in the AAA's Rules of Arbitration.

         (d) All decisions of the arbitrator(s)  shall be final,  conclusive and
binding on all parties and shall not be subject to  judicial  review,  except to
the extent set forth in the Rules of Civil  Procedure  for the  Commonwealth  of
Massachusetts.

         (e)  Any  proceeding  for  injunctive   relief   (including   temporary
restraining orders,  preliminary  injunctions and permanent  injunctions) may be
brought in any court of competent  jurisdiction,  and the parties consent to the
non-exclusive  jurisdiction of the courts of the  Commonwealth of  Massachusetts
for such purpose.

         15.8.    SECTION HEADINGS.

                                       38
<PAGE>

         The headings of  subdivisions  of this Agreement are for convenience of
reference  only  and  shall  not  limit or  control  the  meaning  of any of the
provisions hereof.

         15.9.    ASSIGNS.

         This  Agreement  shall be binding  upon and inure to the benefit of the
parties hereto and their respective  successors and permitted  assigns.  Neither
this Agreement nor the obligations of any party hereunder shall be assignable or
transferable  by such  party  without  the prior  written  consent  of the other
parties hereto.

         15.10.   FURTHER ASSURANCES.

         TPH,  Parent and  Acquisition  Sub shall execute and deliver such other
instruments as may be reasonably  required in connection with the performance of
this Agreement and each shall take all such further actions as may be reasonably
required to carry out the transactions contemplated by this Agreement.

                                       39

<PAGE>


         15.11.   NO IMPLIED RIGHTS OR REMEDIES.

         Except as  otherwise  expressly  provided  herein,  including,  without
limitation, the provisions of Article 13, nothing herein expressed or implied is
intended,  or shall be construed  to confer upon or to give any person,  firm or
corporation,  other than TPH, Parent and Acquisition Sub, any rights or remedies
under or by reason of this Agreement.

         15.12.   COUNTERPARTS.

         This Agreement may be executed in multiple counterparts,  each of which
shall be deemed an original,  but all of which together shall constitute one and
the same agreement.

         15.13.   SATISFACTION OF CONDITIONS PRECEDENT.

         TPH, Parent and  Acquisition  Sub shall each use their  respective best
efforts to cause the satisfaction of the conditions  precedent contained in this
Agreement; provided, however, that nothing contained in this Section 15.13 shall
obligate any party hereto to waive any right or condition under this Agreement.

         15.14.   PUBLIC STATEMENTS OR RELEASES.

         The  parties  hereto each agree that no party to this  Agreement  shall
make, issue or release any public  announcement,  statement or acknowledgment of
the  existence of, or reveal the status of, this  Agreement or the  transactions
provided for herein,  without  first  obtaining the consent of the other parties
hereto.  Nothing  contained in this Section  15.14 shall  prevent any party from
making such  public  announcements  as such party  reasonably  determines  to be
necessary in order to satisfy such party's legal or contractual obligations.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       40

<PAGE>



         IN WITNESS  WHEREOF,  and  intending to be legally  bound  hereby,  the
parties hereto have caused this Agreement to be duly executed and delivered,  by
their respective duly authorized officers in the use of corporate parties, as an
instrument under seal as of the date and year first above written.

                                             CARDIOTECH INTERNATIONAL, INC.



                                    By:      /s/ Michael Adams
                                             -----------------
                                             Name:    Michael Adams
                                             Title:   Chief Operating Officer


                                             CARDIOTECH ACQUISITION CORP.



                                    By:      /s/ Michael Adams
                                             -----------------
                                             Name:    Michael Adams
                                             Title:   Chief Operating Officer


                                             TYNDALE PLAINS-HUNTER, LTD.


                                    By:      /s/ Murray H. Reich
                                             -------------------
                                             Name:    Murray H. Reich
                                             Title:   President

                                       41






                CardioTech International, Inc. Gains Significant
                  Technology in Connection with Acquisition of
                           Tyndale-Plains Hunter, LTD

For Immediate Release

         Woburn, MA (July 19, 1999): CardioTech International,  Inc., (AMEX:CTE)
announced that it has completed its acquisition of  Tyndale-Plains  Hunter,  LTD
("TPH").  TPH,  located  in  Lawrenceville,  New  Jersey,  is a  leader  in  the
manufacture of hydrophilic polyurethanes.  Hydrophilic polyurethanes are used to
provide  permanent  lubricity to the surface of medical  devices,  improve blood
compatibility,   and  act  as  controlled   delivery  systems.   TPH's  patented
hydrophilic,  or "water-loving"  technology,  provides CardioTech the ability to
integrate this key technology  into the vascular  access and peripheral  grafts.
The Company believes this technology will result in significant improvements and
benefits to its family of vascular grafts and other implantable devices.

         CardioTech  completed the  acquisition  of TPH on July 15, 1999 through
the  issuance  of  446,153  shares  of the  Company's  Common  Stock,  valued at
approximately $725,000, and cash of $350,000. TPH will operate as a wholly-owned
subsidiary of CardioTech. The acquisition was recorded under the purchase method
of accounting.  TPH recorded revenues of approximately  $600,000 (unaudited) for
its fiscal year ended March 31, 1999.

<PAGE>


         Dr. Michael Szycher,  CEO and President of CardioTech  stated,  "We are
extremely  pleased  to  have  successfully  completed  the  acquisition  of TPH.
Management  believes  that  TPH  will  contribute  positively  to the  Company's
revenues and  earnings.  More  importantly,  however,  the  technology  provided
through TPH's hydrophilic  polyurethanes,  and TPH's expertise in developing and
manufacturing  these  polyurethanes,  should  result  in  notable  technological
advancements and contributions to CardioTech's continued development of superior
vascular grafts. In addition, CardioTech will be the only company in the country
with an  established,  full  product  line of premium  polyurethane  elastomers,
having  characteristics  ranging from  hydrophilic to  hydrophobic.  We are also
pleased to announce that Dr. John Hudson will manage CardioTech's TPH subsidiary
in his capacity as Operations Manager."

         Speaking on behalf of the Board of Directors and  shareholders  of TPH,
Howard Nashel Esq., attorney for TPH, stated "We are excited about the potential
for  increasing  our  shareholders'  value as a result of this  transaction.  We
expect  CardioTech to exploit TPH's  hydrophilic  technology  and integrate this
technology as part of their advanced medical  devices,  resulting in implantable
devices with superior performance in the cardiovascular arena."

<PAGE>



         CardioTech International,  Inc. is a leading developer and manufacturer
of advanced,  microporous,  polyurethane-based  vascular  graft  devices for the
treatment of late-stage  cardiovascular  disease.  The Company is also a leading
developer  and  manufacturer  of patented  polyurethane  compounds.  The Company
received CE mark for its VascuLink  vascular  access graft in November 1998, and
is  currently  marketing  the  product  through  its  international  distributor
network. The Company's corporate and operational  headquarters in Woburn, MA and
will  be  complemented  by the  addition  of the  TPH  operational  facility  in
Lawrenceville,  New Jersey. In addition, the Company maintains its international
operating subsidiary in Brymbo, Wrexham, UK.

         The Company  believes  that this  release  may contain  forward-looking
statements  that are subject to risks and  uncertainties,  including  statements
regarding  the value of TPH's  technology,  CardioTech's  ability  to  integrate
successfully  TPH's technology into CardioTech's  vascular access and peripheral
grafts and the effect of the acquisition on CardioTech's  revenues and earnings.
Such statements are based on management's  current  expectations and are subject
to a number of factors that could cause actual results to differ materially from
the forward-looking statements. The Company cautions investors that there can be
no assurance that actual results will not differ materially from those projected
or suggested in such forward-looking statements, as a result of various factors,
including but not limited to the following: the possible delisting of Cardiotech
on the AMEX, the Company's ability to obtain additional  funding,  the Company's
ability to successfully manage its growth and integrate TPH into its operations,
the Company's ability to successfully  manufacture,  market,  and distribute its
products,  the  Company's  ability to obtain  financing  to support  its working
capital  needs,  intense  competition  related to the  development  of synthetic
grafts and difficulties  inherent in developing  synthetic  grafts. As a result,
the Company's further development involves a high degree of risk.

Contact:
Michael Szycher, Ph.D.
Chief Executive Officer
(781) 933-4772
(July 19, 1999)




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