CALGENE INC /DE/
PRE 14A, 1996-09-04
AGRICULTURAL PRODUCTION-CROPS
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<PAGE>
 
                            SCHEDULE 14A INFORMATION

                  PROXY STATEMENT PURSUANT TO SECTION 14(A) OF
                      THE SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:
[X] Preliminary Proxy Statement         [ ] Confidential, for Use of
                                             the Commission Only
                                             (as permitted by
                                             Rule 14a-6(e)(2))

[ ] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to (S)240.14a-11(c) or (S)240.14a-12

                                 CALGENE, INC.
              --------------------------------------------------
               (Name of Registrant as Specified In Its Charter)
                                        
                 --------------------------------------------
                   (Name of Person(s) Filing Proxy Statement
                         if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X] $125 per Exchange Act Rules 0-11(c)(1)(ii),
    14a-6(i)(1), or 14a-6(i)(2)
[ ] $500 per each party to the controversy pursuant to Exchange Act Rule 14a-
    6(i)(3)
[ ] Fee computed on table below per Exchange Act
    Rules 14a-6(i)(4) and 0-11
 
    (1)  Title of each class of securities to which transaction applies:
    (2)  Aggregate number of securities to which transaction applies:
    (3)  Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11:
    (4)  Proposed maximum aggregate value of transaction:
    (5)  Total Fee paid:

[ ] Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously.  Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.

    (1)  Amount Previously Paid:
    (2)  Form, Schedule or Registration Statement No.:
    (3)  Filing Party:
    (4)  Date Filed:
<PAGE>
 
                                 CALGENE, INC.



                                          October 3, 1996



To the Stockholders of Calgene, Inc.:

     You are cordially invited to attend the Annual Meeting of Stockholders of
Calgene, Inc. (the "Company") on Thursday, October 31, 1996 at 10:00 a.m. local
time.  The Annual Meeting will be held at the Varsity Theatre, 616 Second
Street, Davis, California.

     A description of business to be conducted at the Annual Meeting is set
forth in the attached Notice of Annual Meeting and Proxy Statement.  Also
enclosed is a copy of our Annual Report to Stockholders for the fiscal year
ended June 30, 1996.

     Whether or not you plan to attend the Annual Meeting, please mark, sign,
date and return the enclosed proxy card promptly in the accompanying envelope.
By returning the proxy, you can help the Company avoid the expense of duplicate
proxy solicitations and possibly having to reschedule the Annual Meeting if a
quorum of the outstanding shares is not present or represented by proxy.  If you
attend the Annual Meeting and wish to change your proxy vote, you may do so
simply by voting in person at the Annual Meeting.



                                    Lloyd M. Kunimoto
                                    President
<PAGE>
 
                                 CALGENE, INC.
                               1920 Fifth Street
                            Davis, California 95616
                           __________________________

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                        TO BE HELD ON OCTOBER  31, 1996

          NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of
Calgene, Inc. (the "Company") will be held on Thursday, October 31, 1996 at
10:00 a.m., local time, at the Varsity Theatre, 616 Second Street, Davis,
California for the following purposes:

          1. To elect directors of the Company.

          2. To approve the Stock Purchase Agreement dated_____________, 1996
 ("Stock Purchase Agreement") between Calgene and Monsanto Company, a Delaware
 Company ("Monsanto") pursuant to which (i) Calgene would issue 6,250,000 shares
 of Common Stock to Monsanto for $8.00 per share for an aggregate purchase price
 of $50 million, thereby increasing Monsanto's ownership interest in shares of
 Calgene Common Stock from 49.9% to approximately 54.6% (without giving effect
 to the exercise of outstanding options and warrants), (ii) Monsanto and Calgene
 would enter into a Restated Stockholders Agreement ("Restated Stockholders
 Agreement") amending and restating the Stockholders Agreement dated March 31,
 1996 ("Stockholders Agreement") as more fully described in the Proxy Statement,
 and (iii) the Company's Restated Certificate of Incorporation would be amended
 to reflect the amendments to the Stockholders Agreement contemplated by the
 Restated Stockholders Agreement (the foregoing transactions are hereinafter
 collectively referred to as the "Monsanto Transaction").

          3. To increase the authorized number of shares of Common Stock 
 from 80,000,000 to 100,000,000 shares.

          4. To confirm the appointment of Ernst & Young LLP as the independent
auditors of the Company through the fiscal year ending December 31, 1997.

          5. To transact such other business as may properly come before the 
meeting.

          The foregoing items of business are more fully described in the 
Proxy Statement accompanying this Notice.

          Holders of Common Stock of record at the close of business on
September 23, 1996 are entitled to vote at the Annual Meeting.

                                    FOR THE BOARD OF DIRECTORS



                                    MICHAEL J. MOTRONI
                                    Secretary

Davis, California
October 3, 1996


                                   IMPORTANT

          TO ENSURE YOUR REPRESENTATION AT THE MEETING, YOU ARE URGED TO MARK,
SIGN, DATE AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN THE POSTAGE-
PREPAID ENVELOPE ENCLOSED FOR THAT PURPOSE.  IF YOU ATTEND THE MEETING, YOU MAY
VOTE IN PERSON EVEN IF YOU RETURN A PROXY.
<PAGE>
 
                                  CALGENE, INC.
                                  ____________

                                PROXY STATEMENT

                         ANNUAL MEETING OF STOCKHOLDERS

                                OCTOBER 31, 1996

                             INFORMATION CONCERNING
                         VOTING AND PROXY SOLICITATION


          The enclosed proxy is solicited on behalf of the Board of Directors of
Calgene, Inc. ("Calgene" or the "Company") for use at the Annual Meeting of
Stockholders to be held on Thursday, October 31, 1996 at 10:00 a.m., local time,
or at any adjournment of the Annual Meeting.  The Annual Meeting will be held at
the Varsity Theatre, 616 Second Street, Davis, California.

          The Company's principal executive offices are located at 1920 Fifth
Street, Davis, California 95616. This Proxy Statement is being mailed to
stockholders on or about October 3, 1996.

          Only holders of Common Stock of record at the close of business on
September 23, 1996 (the "Record Date") are entitled to vote at the meeting.  On
the Record Date, __________ shares of the Company's Common Stock were issued and
outstanding.  The affirmative vote of the holders of a plurality of the shares
of Common Stock present or represented at the Annual Meeting is required for the
election of directors.   Each share is entitled to one vote for each of the nine
nominees, unless a stockholder notifies the Secretary of the Company prior to
the commencement of voting of the stockholder's intention to cumulate votes.  In
that event, each share will be entitled to nine votes, which a stockholder may
cast for a single candidate or distribute among up to nine candidates, but such
cumulative voting will only apply to candidates who have been properly nominated
prior to the commencement of voting. The affirmative vote of the holders of a
majority of the shares of Common Stock present or represented at the Annual
Meeting, other than broker non-votes (as defined below) and other than those
held by Monsanto, is required for the approval of the Monsanto Transaction.  The
affirmative vote of the holders of a majority of the shares of Common Stock
outstanding on the Record Date is required for the approval of the proposed
amendment to the Certificate of Incorporation to increase the authorized number
of shares of Common Stock from 80,000,000 to 100,000,000 shares, and the
approval of the holders of a majority of the shares of Common Stock present or
represented at the Annual Meeting is required for the ratification of the
selection of Ernst & Young LLP as the Company's independent auditors through the
fiscal year ending December 31, 1997.  A majority of the shares entitled to
vote, present in person or represented by proxy (including those held by
Monsanto), will constitute a quorum at the Annual Meeting.  For purposes of
determining a quorum, shares represented by all valid proxies received will be
counted, including proxies that contain instructions to abstain as to certain
votes and proxies filed by brokers or others indicating that their voting
authority does not extend to all agenda items ("broker non-votes").

          A proxy given pursuant to this solicitation may be revoked by the
person giving it at any time before its use by delivering to the Secretary of
the Company a written notice of revocation or a duly executed proxy bearing a
later date, or by attending the meeting and voting in person.

          The cost of soliciting proxies will be borne by the Company.  If the
Company decides to retain the services of a proxy solicitor, the Company
estimates that it would pay a fee not to exceed $6,000.  In addition, the
Company expects to reimburse brokerage firms and other persons representing
beneficial owners of shares for their expense in forwarding solicitation
material to such beneficial owners.  Proxies 

<PAGE>
 
may be solicited by certain of the Company's directors, officers and regular
employees, without additional compensation, in person or by telephone or
facsimile.

                                STOCK OWNERSHIP

          The following table sets forth the beneficial ownership of Common
Stock of the Company as of July 31, 1996 by each director, by each executive
officer shown in the Summary Compensation Table (see "Executive Compensation"),
by all directors and executive officers as a group and by each person known by
the Company to be a beneficial owner of more than 5% of the shares outstanding.
<TABLE>
<CAPTION>
 
                               
                                      Shares Beneficially    Approximate Percent
                                           Owned(1)               Owned (2)
                                      ____________________   ___________________
<S>                                        <C>                   <C>
Roger H. Salquist.........................    239,940                *

Robert E. Baker...........................     15,000                *

Andrew Baum...............................     49,817               --

Patrick J. Fortune........................         --               --

Robert T. Fraley..........................         --               --

Jeffrey D. Gargiulo.......................      6,667                *

Michael R. Hogan..........................         --               --

Thomas F. Hughes..........................     28,618                *

Lloyd Kunimoto............................     38,263                *

Danilo Lopez..............................         --               --

Michael J. Motroni........................      37,040               *

Howard D. Palefsky........................      14,500               *

John E. Robson............................      19,167               *

Roderick N. Stacey........................     107,830               *

Allen J. Vangelos.........................      14,600               *

Hendrik A. Verfaillie.....................          --              --

All executive officers and                     
directors as a group (16 persons).........     587,692               *

Monsanto Company..........................  30,146,114            49.9%   
   800 North Lindbergh
    Boulevard,St. Louis, MO  63137(3)       

- - - ----------------------------
</TABLE>

   *      Less than 1%.
   (1)    The Company believes that all beneficial owners named in the table
          have sole voting and investment power with respect to the shares they
          beneficially own.  The shares shown in the table to be beneficially
          owned include any shares that the person has the right to acquire
          within 60 days of July 31, 1996 by exercise of any stock option for
          which the Company has knowledge.  The shares subject to such options
          are as follows: Mr. Salquist: 209,762; Mr. Baker: 14,500;  Mr. Baum:
          41,116; Mr. Gargiulo: 6,667; Mr. Hughes: 26,544; Mr. Kunimoto: 31,366;
          Mr. Motroni:  37,040; Mr. Palefsky: 13,500; Mr. Robson: 4,167; Mr.
          Stacey: 107,830; Mr. Vangelos:  14,500; and all executive officers and
          directors as a group: 513,242.

                                      -2-
<PAGE>
 
   (2)    Percent of the 60,443,115 outstanding shares of Common Stock,
          counting as outstanding for each named person all shares issuable to
          such person on exercise of options that are  included in the first
          column.
   (3)    Does not include the 6,250,000 shares of Calgene Common Stock
          ("Additional Shares") which would be issued if the Monsanto
          Transaction is consummated, which would increase Monsanto's holdings
          to approximately 54.6% (without giving effect to the exercise of
          outstanding options and warrants).

 
                                 PROPOSAL NO. 1

                             ELECTION OF DIRECTORS

          A board of nine directors will be elected at the Annual Meeting.
Unless otherwise instructed, the proxy holders will vote the proxies received by
them for the nine nominees of the Board of Directors named below.  Except for
Messrs. Fortune and Hogan, all of the nominees are presently directors of the
Company.  If any nominee is unable or declines to serve as a director at the
time of the Annual Meeting, the proxies will be voted for any nominee who shall
be designated by the current Board of Directors to fill the vacancy in
accordance with the Stockholders Agreement.  It is not expected that any nominee
will be unable or will decline to serve as a director.  If stockholders nominate
persons other than the Board's nominees for election as directors, the proxy
holders will vote all proxies received by them in accordance with cumulative
voting to assure the election of as many of the Board's nominees as possible.

          Directors are elected by a plurality of the votes cast.  Proxies
marked to withhold authority to vote for one or more nominees, and broker non-
votes, will not be counted as votes cast.  Each share is entitled to one vote
for each of the nine nominees, unless a stockholder notifies the Secretary of
the Company prior to the commencement of voting of the stockholder's intention
to cumulate votes.  In that event, each share will be entitled to nine votes,
which a stockholder may cast for a single candidate or distribute among up to
nine candidates, but such cumulative voting will only apply to candidates who
have been properly nominated prior to the commencement of voting.

          Messrs. Verfaillie, Fraley, Robson, Hogan and Fortune have been
designated by Monsanto in accordance with the Stock Purchase Agreement and the
Restated Stockholders Agreement between Calgene and Monsanto.  The election of
Messrs. Verfaillie, Fraley, Robson, Hogan and Fortune is a condition precedent
to Monsanto's purchase of the Additional Shares.  See "Approval of Transaction
with Monsanto."

          The Board of Directors recommends a vote FOR the nominees listed
below:
<TABLE>
<CAPTION>
 
                                                                Director
Name of Nominee             Age  Principal Occupation            Since
- - - ---------------             ---  --------------------            -----

<S>                        <C>   <C>                             <C>
Patrick J. Fortune.........  49  Chief Information Officer of       __
                                 Monsanto Company

Robert T. Fraley...........  43  President of Ceregen (a           1996
                                 business unit of Monsanto
                                 Company)

Michael R. Hogan...........  43  Vice President and Corporate       __
                                 Controller of Monsanto Company

Lloyd Kunimoto.............  43  President and Acting Chief        1996
                                 Executive Officer of the
                                 Company
</TABLE> 
                                      -3-
<PAGE>
<TABLE> 
<CAPTION> 
<S>                         <C>  <C>                              <C>  
Howard D. Palefsky........   49  Chairman and Chief Executive      1986
                                 Officer of Collagen
                                 Corporation

John E. Robson.............  66  Senior Advisor of Robertson,      1996
                                 Stephens & Company

Roger H. Salquist..........  55  Consultant; Former Chairman       1981
                                 and Chief Executive Officer
                                 of the Company

Allen J. Vangelos..........  64  President and Chief Executive     1994
                                 Officer of Calavo Growers of
                                 California

Hendrik A. Verfaillie......  51  Executive Vice President of       1996
                                 Monsanto Company

</TABLE>

     The term of office of each person elected as a director will continue until
the next Annual Meeting of Stockholders or until his or her successor has been
elected. The terms of the Stockholders Agreement and Restated Stockholders
Agreement set forth the rights of Calgene and Monsanto to designate nominees to
the Board of Directors. See "Approval of Transaction with Monsanto -- Summary of
Stockholder Agreement and Restated Stockholder Agreement." There is no family
relationship between any director and any other director or executive officer of
the Company.

     Mr. Fortune was appointed Corporate Vice President, Information Technology
and Chief Information Officer of Monsanto Company in October 1995. From August
1994 to August 1995 Mr. Fortune was President and Chief Operating Officer of
Coram-Healthcare Corporation, whose business is home infusion therapy for cancer
and AIDS patients. From 1991 to 1994 Mr. Fortune was Corporate Vice President
Information Management for Bristol-Meyers Squibb. From 1989 to 1991 Mr. Fortune
was Senior Vice President and General Manager of Packaging Corporation of
America prior to which he served as Vice President, Information Services and
Corporate Vice President of the Parenterals Group of Baxter International. He is
also a member of Board of Directors of Parexel Corporation (a clinical research
organization) and serves on the Board of Visitors of the School of Physical
Sciences at the University of Chicago.

     Mr. Fraley was named President of Ceregen, a business unit of Monsanto, in
1995. From 1993 to 1995, Mr. Fraley was Vice President, New Products Division,
of the Monsanto Agricultural Products Group. From 1990 to 1993, Mr. Fraley was
Vice President, Research and Development, New Products Division, of the Monsanto
Agricultural Products Group.

     Mr. Hogan was appointed Corporate Vice President and Corporate Controller
of Monsanto Company in January 1996. From 1986 to 1995, Mr. Hogan was Executive
Vice President of General American Life and while holding such position also
served as President and director of Gencore Health Systems, Inc. and its
predecessor organization from 1990 through 1994..

     Mr. Kunimoto has been the President and Acting Chief Executive Officer
since July 1996. From June 1995 to July 1996 Mr. Kunimoto served as Vice
President of Strategic Planning and Business Development. From November 1983 to
June 1995 , Mr. Kunimoto served in several senior management positions with the
Company.

                                      -4-
<PAGE>
 
     Mr. Palefsky has been the Chairman and Chief Executive Officer of Collagen
Corporation, a medical products company, since 1995. He served as President and
Chief Executive Officer of Collagen Corporation from 1978 to 1995. He is also a
director of Collagen Corporation, Target Therapeutics, Inc., and Innovasive
Devices, Inc., all medical products companies.

     Mr. Robson has been a Senior Advisor of Robertson, Stephens & Company since
1993. From 1989 to 1992 Mr. Robson was Deputy Secretary of the United States
Treasury. Mr. Robson is also a director of Northrop Grumman Corporation, an
aerospace and defense company and Security Capital Industrial Trust, a real
estate investment trust.

     Mr. Salquist has been a consultant to the Company since August 1996. Mr.
Salquist had previously served as an executive officer of the Company since
September 1983 and its Chief Executive Officer since November 1985. Mr. Salquist
is a director of Collagen Corporation , a medical products company.

     Mr. Vangelos has been the President and Chief Executive Officer of Calavo
Growers of California since September 1986, prior to which he held management
positions at Castle & Cooke, including Vice President and General Manager of
Processed Products and President of International Diversified Business and Fresh
Marketing. From 1980 to 1984, he was the Chief Executive Officer of Impact
Corporate Group, a food brokerage company. Mr. Vangelos was the 1993 Chairman of
the Board of Directors of the Agricultural Council of California and a past
Chairman of the United Fresh Fruit and Vegetable Association.

     Mr. Verfaillie was appointed an Executive Vice President of Monsanto
Company in July 1995. Prior to this he served as President of The Agricultural
Group, Vice President and Advisory Director-Monsanto Company from 1993 to 1995,
Vice President and General Manager, Roundup Division-The Agricultural Group from
1990 to 1993, and Vice President-Commercial Development-Monsanto Agricultural
Company from 1986 to 1990.

BOARD MEETINGS, COMMITTEES AND DIRECTOR COMPENSATION

     The Board of Directors of the Company (the "Board") held four meetings
during the fiscal year ended June 30, 1996. No nominee attended fewer than 75%
of the meetings of the Board of Directors and of the committee of the Board on
which he served that were held during the period of the director's service
except for Mr. Stinnett who passed away in January 1996.

     The Board has an Audit Committee, a Human Resources Committee and a
Replacement/Retention Committee. From time to time, the Board has created
various ad hoc committees for special purposes.

     The Audit Committee consists of Messrs. Palefsky, Robson and Fraley. The
Audit Committee held three meetings in the last fiscal year. The Audit Committee
recommends engagement of the Company's independent auditors and is primarily
responsible for approving the services performed by the Company's independent
auditors and for reviewing and evaluating the Company's accounting principles
and its system of internal accounting controls.

     The Human Resources Committee consists of Messrs. Vangelos, Verfaillie and
Baker. The Human Resources Committee held two meetings during the last fiscal
year. The Human Resources Committee considers and makes recommendations to the
Calgene Board of Directors concerning general compensation policies and employee
benefit plans and specifically recommends salary levels and bonus awards for
certain senior executive officers, including the Chief Executive Officer. The
Human Resources Committee also administers Calgene's stock option plan and has
sole authority to grant options to officers. The Human Resources Committee's
executive salary and bonus recommendations for fiscal 1996 were approved by the
Calgene Board of Directors without modifications.

                                      -5-
<PAGE>
 
     The Retention/Replacement Committee consists of Messrs. Palefsky,
Verfaillie and Robson. The Retention/Replacement Committee held no meetings
during the last fiscal year. The Retention/Replacement Committee is responsible
for the retention and/or replacement of all of the executive officers of the
Company. Under the terms of the Restated Stockholders Agreement the
Retention/Replacement Committee would be eliminated, thus leaving the Calgene
Board of Directors thereafter responsible for the retention and/or replacement
of all of the executive officers of the Company.

     Directors who are not also employees of the Company or its subsidiaries
receive a fee of $1,000 per meeting ($250 per telephone meeting) attended, $500
per Board committee meeting attended (unless held on the same day as a Board
meeting) and a monthly retainer of $1,000, plus out-of-pocket travel expenses.
Prior to April 1, 1996, directors received an annual retainer of $3,000
(accruing and payable $250 per month). Under the 1991 Stock Option Plan, non-
employee directors receive an option to purchase 10,000 shares of Common Stock
at the time of their initial election to the Board, and receive annually
thereafter options to purchase 3,000 shares of Common Stock. These automatically
granted options have terms of five years (subject to continued service on the
Board), become exercisable in equal monthly increments over the twelve months
following the respective grant dates and have exercise prices equal to the fair
market value of the Common Stock on their respective dates of grant. On March
25, 1996, annual options were automatically granted to each of the nonemployee
directors then serving at an exercise price of $6.00 per share.

    There were no consulting fees paid to directors in fiscal 1996.

     In addition to the fees listed above, Monsanto Company transferred to Mr.
Robson 15,000 shares of Common Stock of the Company pursuant to the terms of a
letter agreement dated May 6, 1996 between John E. Robson and Monsanto Company.
Such shares are subject to a three-year vesting period, under which 33 1/3% of
the total number of shares originally granted become non-forfeitable on each
March 31 commencing March 31, 1997.


                             EXECUTIVE COMPENSATION

SUMMARY OF CASH AND OTHER COMPENSATION

     The following table provides certain summary information concerning
compensation earned during the last three fiscal years by the Company's Chief
Executive Officer and each of the four other most highly compensated executive
officers of the Company who were serving at the end of fiscal 1996 (the "named
executive officers"). The table also includes such information for two former
executive officers who at the end of fiscal 1996 were no longer employed by the
Company or a subsidiary of the Company.

                                      -6-
<PAGE>
 
                                 SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                               Long-Term
                                                                                               Compensation
                                                       Annual Compensation(1)                     Awards
                                              -------------------------------------------       ---------
                                                                               Other Annual     Securities          All Other
Name ans Principal                 Fiscal          Salary          Bonus       Compensation     Underlying        Compensation   
Position                            Year             ($)           ($)             ($)          Options (#)           $(2)
- - - ------------                        ----            -----          ----           --           -----------           ------
<S>                          <C>          <C>                     <C>           <C>              <C>            <C>
Roger H. Salquist (3)(4)            1996           $275,577       $  --            ----                 --              $3,596
 Chairman of the Board and          1995            242,404          --            ----            100,000               1,212
 Chief Executive Officer            1994            225,865          --            ----            104,762                  --
                                                                                                                   
Andrew Baum                         1996            160,046        10,000          ----             40,000               3,280
 Vice President                     1995            162,600        10,000          ----             25,000                 840
                                    1994            154,592          --            ----                 --                  --

Thomas Hughes                       1996            125,261        25,000          ----             55,175               3,002
 Division President,                1995            106,731        25,000          ----             22,825               1,142
 Stoneville Pedigreed Seed          1994             89,462          --            ----             10,000                 977
 Company                                                                                                           
                                                                                                                   
Lloyd Kunimoto(5)                   1996            140,000        60,000          ----             50,000               2,800
 Vice President                     1995            140,538          --            ----             25,000                 754
                                    1994            135,519         4,808          ----                 --                  --

Michael J. Motroni                  1996            140,230           --        100,000             20,000               2,962
 Vice President of Finance          1995            120,461           --           ----             15,000                 647
 and Secretary                      1994            107,135         3,654          ----                 --                  --
                                                                                                                   

Roderick N. Stacey                  1996            198,462           --        695,000                 --               6,524
 Former President and Chief         1995            233,558           --           ----                 --               1,077
 Operating Officer                  1994            200,673           --          6,679            100,000                  --
                                                                                                                   

Danilo Lopez                        1996            148,077           --        131,250                 --               2,558
Former President, Calgene           1995            171,635           --           ----            100,000                 815
 Fresh                                                                                                             
 
</TABLE>
____________________

(1)  Includes amounts earned in the fiscal year even if paid in the subsequent
     fiscal year or deferred pursuant to the Company's 401(k) savings plan.
     Excludes amounts paid during the fiscal year that were earned in a prior
     year.
(2)  Amounts reported as "All Other Compensation" represent the Company's
     matching contributions under its 401(k) savings plan.
(3)  The options shown in the table as granted to Mr. Salquist in fiscal 1994
     were originally granted in 1987 for a six-year term and extended for four
     additional years in fiscal 1994.
(4)  In August 1996 Mr. Salquist resigned as Chairman of the Board and Chief
     Executive Officer. Mr. Salquist remains as a member of the Board and has
     also become a consultant to the Company. See "Executive Compensation -
     Change of Control Employment Agreements."
(5)  Since the resignation of Mr. Salquist, Mr. Kunimoto has served as Acting
     Chief Executive Officer.

                                      -7-
<PAGE>
 
CHANGE OF CONTROL EMPLOYMENT AGREEMENTS

     Messrs. Salquist, Stacey and Motroni entered into Change of Control
Employment Agreements, dated as of July 19, 1995, with the Company.  Each
agreement becomes effective only upon a Change of Control (as defined) of the
Company and provides that, if the employment of the officer is terminated by the
Company without Cause (as defined) or by the officer for Good Reason (as
defined) within the three-year term of the agreement or if (in the case of Mr.
Salquist) he resigns upon the six-month or three-year anniversaries of the
effective date of the agreement, the officer shall receive severance benefits
that include a payment equal to 2.99 times his base salary and average bonus for
the prior three fiscal years.  For purposes of such agreements, a Change of
Control included the closing of the transaction on March 31, 1996 pursuant to
which Monsanto Company acquired a 49.9% equity interest in the combined business
of the Company and Gargiulo, L.P. (the "Initial Monsanto Transaction").  See
"Certain Transaction -Reorganization Agreement".

     In connection with his resignation following the closing of the Initial
Monsanto Transaction, Mr. Stacey and the Company entered into an amendment to
his Change of Control Employment Agreement pursuant to which Mr. Stacey agreed
that payments required to be made to him under such agreement would be paid over
a one-year period rather than in a lump sum.  The amended agreement provided for
the payment of $347,500 upon Mr. Stacey's resignation and monthly payments of
$9,000 during a 12 month consulting period and an additional payment of $239,500
at the end of the 12 month period.

     In connection with his resignation in August 1996, Mr. Salquist and the
Company entered into an amendment to his Change of Control Employment Agreement
pursuant to which Mr. Salquist agreed that payments required to be made to him
under such agreement would be paid over a 13 month period rather than in a lump
sum.  The amended agreement provided for the payment of $315,000 upon Mr.
Salquist's resignation and monthly payments of $25,000 during a 12 month
consulting period and an additional payment of $290,000 at the end of the 12
month period.

                                      -8-
<PAGE>
 
Stock Option Tables

     The following table provides information regarding stock options granted in
fiscal 1996 to the named executive officers in the Summary Compensation Table.
In accordance with rules of the Commission, the table shows the hypothetical
gains that would be produced by the respective options based on assumed 5% and
10% rates of annual compound stock price appreciation from the date the options
were granted until the end of the ten-year option terms.  The actual value an
executive may realize will depend on the spread between the market price and the
exercise price on the date the option is exercised.
<TABLE>
<CAPTION>
                                                 OPTION GRANTS IN LAST FISCAL YEAR
                                                 ---------------------------------

 
                                               Individual Grants                         Potential
                                      --------------------------------------------    Realized Value  
                                                 Percent of                             at Assumed
                                                   Total                              Annual Rates of 
                                        Number    Options                               Stock Price
                                       of Shares  Granted                             Appreciation for
                                       Underlying   to                                   Option Term
                                        Options  Employees                                  ($)(3)
                                        granted  in Fiscal    Exercise   Expiration   -------------------
                                        (#)(1)    Year (%)   Price ($)(2)   Date         5%         10%
                                         -----     ------    -----------    -----       -----      -----
<S>                                 <C>           <C>       <C>           <C>         <C>         <C>
Roger H. Salquist                          ---       ---        ---         ---         ---          ---

Andrew Baum                             40,000      2.00       5.75       4/22/06      144,646      366,561

Thomas Hughes                              175        --       6.75       7/27/05          743        1,883
                                        25,000      1.25       5.688      3/22/06       89,429      226,630
                                        30,000      1.51       5.75       4/22/06      108,484      274,921

Lloyd Kunimoto                          50,000      2.51       5.75       4/22/06      180,807      458,201

Michael J. Motroni                       5,000       .25       4.75      12/18/05       14,936       37,851
                                        15,000       .75       5.75       4/22/06       54,242      137,460

Roderick N. Stacey                         ---       ---        ---           ---          ---          ---

Danilo Lopez                               ---       ---        ---           ---          ---          ---

</TABLE>

_______________________
(1)  Newly granted options have terms of ten years and become exercisable
     incrementally in equal monthly amounts over a period of five years from the
     date of grant.  The committee that administers the stock option plan may,
     with the consent of the option holder, modify the terms (including price)
     of outstanding options.
(2)  The exercise price may be paid in cash or by delivery of already-owned
     shares, subject to certain conditions.
(3)  At assumed rates of appreciation of 5% and 10%, compounded annually, the
     Common Stock would appreciate in value 63% and 159%, respectively, over a
     ten-year period.  These mandated computations do not represent the
     Company's estimate or projection of future Common Stock prices.

                                      -9-
<PAGE>
 
OPTION EXERCISES AND FISCAL YEAR-END VALUES

     The following table shows stock options exercised by the named executive
officers in the Summary Compensation Table during fiscal 1996, the aggregate
value of gains on the dates of exercise, the number of shares covered by both
exercisable and non-exercisable stock options as of fiscal year-end, and the
year-end values for such options.
<TABLE>
<CAPTION>
 
                                            AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                                                 AND FISCAL YEAR END OPTION VALUES
                                                          

                                                                     Number of Shares
                                                                   Underlying Unexercised      Value of Unexercised In-the-
                                                                    Options at Fiscal            Money Options at Fiscal
                                   Shares                              Year-End(#)                   Year-End($)(1)
                                   Acquired                     ----------------------------    ---------------------------
                                     on           Value           
                                 Exercise(#)    Realized($)(1)   Exercisable    Unexercisable   Exercisable   Unexercisable
                                 -----------    --------------   -----------    -------------   -----------   -------------
<S>                             <C>            <C>             <C>              <C>             <C>          <C>      
Roger H. Salquist                     --              --           202,262           92,500        144,048        --

Andrew Baum                           --              --            37,134           62,866          1,166      33,834

Thomas Hughes                         --              --            20,610           79,390          2,046      47,629

Lloyd Kunimoto                        --              --            26,884           73,116          1,459      42,291

Michael J. Motroni                    --              --            33,085           41,915          2,782      19,718

Roderick N. Stacey                    --              --           107,830          160,170         10,500        --

Danilo Lopez                          --              --              --              --              --          --

</TABLE>

_______________________

(1)  Value is based on market value of the Common Stock at exercise date (for
     value realized), or at year end (for value of unexercised options), minus
     the option exercise price.


                 REPORT OF THE EXECUTIVE COMPENSATION COMMITTEE

COMPOSITION AND FUNCTIONS OF THE COMMITTEE

     The Human Resources Committee (referred to in this report as the
"Committee") consists of three non-employee directors:  Messrs. Allen J.
Vangelos, Hendrik A. Verfaillie and Robert E. Baker.

                                      -10-
<PAGE>
 
     The Committee performs the functions of a compensation committee.  The
Committee considers and makes recommendations to the Calgene Board of Directors
concerning general compensation policies and employee benefit plans and
specifically recommends salary levels and bonus awards for certain senior
executive officers, including the Chief Executive Officer.  The Committee also
administers Calgene's stock option plan and has sole authority to grant options
to officers.  The Committee's executive salary and bonus recommendations for
fiscal 1996 were approved by the Calgene Board of Directors without
modifications.

OBJECTIVES OF EXECUTIVE COMPENSATION POLICY

     The objectives of Calgene's executive compensation policy are to:

     * set executive compensation at levels sufficient to attract, retain and
       motivate highly qualified executive personnel;

     * align the interests of management and the stockholders by making a
       substantial portion of executive compensation dependent on the
       success of Calgene, as measured by long-term appreciation in the
       market price of Calgene's Common Stock; and

     * balance considerations of individual achievements each year with 
       Calgene's financial and non-financial performance.

     In furtherance of these objectives, Calgene's executive compensation policy
provides for a combination of base salary, cash incentive bonus awards and long-
term stock options.  Calgene also makes matching contributions under its 401(k)
savings plan for all employees that participate, including its executive
officers.  Calgene does not provide its executives with significant perquisites.

SALARY

     In determining its recommendation to the Calgene Board of Directors
concerning the salary of senior executive officers, the Committee considers
published data from annual surveys of executive compensation at other companies
in its field.  With the survey data as a reference point, the Committee makes
adjustments based on its evaluation of Calgene executives' individual levels of
experience, responsibility and past performance.  The Committee also takes into
consideration each executive's comparability with other Calgene executives.  The
Committee typically gives considerable weight to the views of the Chief
Executive Officer with respect to executive salaries other than his own.  Annual
salary adjustments normally become effective in the month of July.

INCENTIVE BONUSES

     The Committee each year sets target maximum cash bonus levels for certain
senior executives and delegates to the Chief Executive Officer the
responsibility to do so for more junior executives.  Fiscal 1996 bonus award
target amounts for senior executives ranged from 33% to 16% of their salaries.
The Committee has formulated five performance categories: (1) individual
contribution toward achieving annual corporate objectives, and the degree to
which Calgene achieves the objectives; (2) achievement of divisional
nonfinancial objectives; (3) achievement of financial objectives; (4)
contribution to building the organization of Calgene's tomato, oils and cotton
business units; and (5) corporate leadership.  These categories include
performance criteria that can be measured against objective standards, and also
criteria that involve subjective determinations.  Each of these categories is
assigned a weight for a particular executive based upon that executive's role
and responsibilities in Calgene.  Each senior executive's performance under
those categories provides a guideline for the Committee's fiscal year-end

                                      -11-
<PAGE>
 
recommendation to the Calgene Board as to what portion, if any, of the target
maximum bonus will be awarded to a particular executive.  The Committee takes
into account the overall corporate financial results and cash position of
Calgene in determining the total bonuses to be awarded.


STOCK OPTIONS

     The granting of stock options is the principal method available to the
Committee to align the interests of the executive officers with those of the
stockholders.  The option will reward the executive only if the market price of
the Common Stock appreciates over the option term and the executive remains
employed by Calgene over the vesting period.  Options granted to executive
officers generally have a ten-year term, vest over a period of five years and
may be exercised at a price per share equal to the market price on the date of
grant.  Stock options are granted to at least some executive officers each year,
as well as to numerous other employees.  The number of shares in an option grant
reflects the executive's position at Calgene, stock options granted to the
executive in the past and the executive's potential contribution to the success
of Calgene.  In granting stock options to senior executive officers, the
Committee has not followed any set of fixed guidelines.

COMPENSATION OF CHIEF EXECUTIVE OFFICER

     The Committee increased the salary of Mr. Salquist from $225,000 in fiscal
1995 to $275,000 in fiscal 1996, reflecting his contributions to the Company and
the consummation of the Initial Monsanto Transaction.

OTHER MATTERS

     The Committee has considered the potential impact of Section 162(m) of the
Internal Revenue Code, which disallows a tax deduction to any publicly-held
corporation for compensation (including non-cash compensation) exceeding $1
million in any year paid to any of the five most highly compensated executive
officers, unless such compensation meets certain requirements.  The cash
compensation of each of Calgene's executive officers is well below $1 million.
The principal non-cash compensation of Calgene executives is from stock options.
Calgene is generally entitled to a tax deduction if an executive exercises a
nonqualified stock option or disposes of shares acquired from the exercise of an
incentive stock option before the required holding period has ended.  The
Committee believes that Calgene stock options either will meet the requirements
of Section 162(M) or will not result in the loss of significant tax deductions.
Taking this into account, as well as Calgene's large tax loss carryover and the
reduced flexibility from a change to the stock option plan to conform to the
requirements of Section 162(m), the Committee has not recommended any change to
the stock option plan.  However, the Committee may consider imposing annual
exercise limitations in some future option grants to executives if Calgene would
otherwise be deprived of significant tax benefits.

     The Calgene Board of Directors approved Change of Control Agreements for
Roger H. Salquist, Roderick N. Stacey and Michael J. Motroni.  These agreements
provide for the payment of severance compensation in the event of termination of
their employment in connection with any Change of Control of Calgene.

     This report is submitted by the following directors, who constituted all
the members of the Committee during fiscal 1996.

                                Robert E. Baker
                               Allen J. Vangelos
                              Hendrik A Verfaillie

                                      -12-
<PAGE>
 
                       COMPENSATION COMMITTEE INTERLOCKS
                           AND INSIDER PARTICIPATION

     During the fiscal year ended June 30, 1996, the members of the Human
Resources Committee were Messrs. Baker, Vangelos and Verfaillie.  None of the
members has ever been an officer or employee of the Company or any of its
subsidiaries.  During fiscal 1996, there were no Committee "interlocks" within
the meaning of the SEC rules, and there continue to be no such "interlocks."

     Mr. Salquist, former Chairman of the Board and Chief Executive Officer,
participated in portions of meetings of the Committee at the invitation of the
Committee and made various proposals to the Committee at its request.  In
addition, at the Committee's direction, Mr. Salquist set the cash compensation
of certain other executives.


                            STOCK PERFORMANCE GRAPH

     The graph below compares the five-year cumulative total returns for Calgene
Common Stock, the Nasdaq Composite Index and a select Peer Group Index of
Companies identified by Calgene.  The graph assumes a $100 investment on June
30, 1991 in Calgene Common Stock and in each of the two indices, and assumes the
reinvestment of all dividends paid by companies represented in the two indices.
The representation of the component companies in the indices is weighted
according to their respective market capitalizations at the end of each period
for which cumulative returns are shown in the graph.  The selected peer group
index consists of the following agricultural biotechnology companies known by
the Company to have their shares traded on the Nasdaq National Market:  Mycogen
Corporation, Ecogen Inc., DNA Plant Technology Corporation and Biosys Inc.  The
graph is in this Proxy in accordance with the rules of the SEC and is not
necessarily indicative of future performance.

<TABLE>
 
<S>                 <C>      <C>      <C>      <C>      <C>      <C>
                    6/30/91  6/30/92  6/30/93  6/30/94  6/30/95  6/30/96
                    -------  -------  -------  -------  -------  -------

Calgene, Inc.           100   120.63   148.51   149.96    95.13    89.88

Nasdaq Composite        100   158.23    186.2   154.69   199.47   249.51

Peer Group Index        100   120.85   124.61   118.34    68.42    71.18
 
</TABLE>

                                      -13-
<PAGE>
 
            SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     The Company's officers and directors are required to file with the
Securities and Exchange Commission reports of their acquisitions and
dispositions of equity securities of the Company.  Based on the Company's review
of copies of such reports received by it, or written representations from
reporting persons, the Company believes that during the fiscal year ended June
30, 1996, its officers and directors filed all required reports on a timely
basis.

                                PROPOSAL NO. 2

                     APPROVAL OF TRANSACTION WITH MONSANTO

     On September __, 1996, the Company entered into a Stock Purchase Agreement
with Monsanto (the "Stock Purchase Agreement"), pursuant to which (i) the
Company agreed to sell and issue to Monsanto, and Monsanto agreed to purchase,
6,250,000 shares of Common Stock of the Company (the "Additional Shares"), at
$8.00 per share, for an aggregate purchase price of $50 million, thereby
increasing Monsanto's ownership interest in shares of Calgene Common Stock from
49.9% to approximately 54.6% (without giving effect to the exercise of
outstanding options and warrants), (ii) Monsanto and Calgene agreed to enter
into a Restated Stockholders Agreement ("Restated Stockholders Agreement")
amending and restating the Stockholders Agreement dated March 31, 1996
("Stockholders Agreement"), and (iii) the Restated Certificate of Incorporation
shall be amended to reflect the amendments to the Stockholders Agreement
contemplated by the Restated Stockholders Agreement (the foregoing transactions
are herein collectively referred to as the "Monsanto Transaction").   On July
30, 1996, the last reported sale price of the Calgene Common Stock on the Nasdaq
National Market was $4.875 per share.  Upon the closing of such purchase,
Monsanto will own approximately 36,396,114 shares of Common Stock of the
Company, representing approximately 54.6% of the issued and outstanding shares
of Common Stock of the Company.  The affirmative vote of the holders of a
majority of the shares of Common Stock present or represented at the Annual
Meeting, other than broker non-votes and shares held by Monsanto, is required
for the approval of the Monsanto Transaction.  The affirmative vote of the
holders of a majority of the shares of Common Stock outstanding on the Record
Date is required for the approval of the proposed amendment to the Certificate
of Incorporation and Monsanto has agreed to vote all of its shares of Common
Stock in favor of such amendment.

REASONS FOR THE TRANSACTION

     In the year ended June 30, 1996, the Company incurred substantial losses
primarily in connection with the  operation of its tomato business.  As of June
30, 1996, the Company had available cash and cash equivalents of $_________ and
working capital of $_________________.

     The Company believes that significant additional funds are required to pay
down debt, fund its tomato operations, to support the market introduction of new
cotton products and to finance continued oils research and  development.  The
Board of Directors of Calgene believes that the proposed transaction with
Monsanto is on terms no less favorable to the Company than could be obtained
from an independent third party.  The Board determined to seek stockholder
approval for the Monsanto Transaction because the transaction will enable
Monsanto to nominate a majority of the members of the Board of Directors of
Calgene.  If the proposed transaction with Monsanto is not approved at the
Annual Meeting, Calgene is unable to predict whether it will be able to obtain
required financing on favorable terms, if at all.

     The Board of Directors recommends a vote FOR the Monsanto Transaction.

                                      -14-
<PAGE>
 
SUMMARY OF STOCK PURCHASE AGREEMENT

     Consummation of the purchase of the Additional Shares by Monsanto pursuant
to the Stock Purchase Agreement is subject to various conditions, including:
(i) expiration of the applicable waiting periods under the Hart-Scott-Rodino
Antitrust Improvements Act of 1976, as amended ("HRS Act"), (ii) election of the
five (5) Monsanto designated directors of the Company by the stockholders of
Calgene, (iii) approval of the Monsanto Transaction, which includes the issuance
of the Additional Shares to Monsanto, by the holders of a majority of the shares
of Calgene Common Stock present or represented at the Annual Meeting, other than
Monsanto, (iv) Calgene shall have executed the Restated Stockholders Agreement,
(v) the Additional Shares shall have been authorized for listing on the Nasdaq
National Market, subject to official notice of issuance, and (vi) between the
date of the Stock Purchase Agreement and the Closing Date there shall have been
no Material Adverse Change (as defined in the Stock Purchase Agreement) in the
position, financial or otherwise, or the operations, assets, liabilities or
results of operations of Calgene or its subsidiaries.

     The Stock Purchase Agreement provides that the closing of the transactions
contemplated thereunder shall occur on the first date after the conditions set
forth therein are satisfied or waived. Absent a request for additional
information by the United States Department of Justice ("DOJ") or the Federal
Trade Commission ("FTC") under the HSR Act and assuming the requisite
stockholder approval at the Annual Meeting with respect to the Monsanto
Transaction, Calgene and Monsanto presently anticipate closing on or about
November __, 1996.  If a request for additional information is issued by the DOJ
or FTC the waiting period under the HSR Act is extended until 20 days after all
the information requested is furnished to the DOJ or FTC.  The Stock Purchase
Agreement provides that either Monsanto or Calgene may terminate the Stock
Purchase Agreement if the conditions for each's benefit as set forth therein are
not satisfied or waived by January 31, 1997.

SUMMARY OF THE STOCKHOLDERS AGREEMENT AND THE RESTATED STOCKHOLDERS AGREEMENT

     As part of the Monsanto Transaction, the Stock Purchase Agreement provides
that, simultaneously with the issuance of the Additional Shares to Monsanto,
Calgene and Monsanto shall enter into the Restated Stockholders Agreement which
amends and restates the existing Stockholders Agreement.  A copy of the proposed
Restated Stockholders Agreement is appended to this Proxy Statement as Exhibit
A.

     The following is a summary of both the existing Stockholders Agreement
which became effective on March 31, 1996 and the proposed Restated Stockholders
Agreement which will become effective upon the consummation of the transactions
contemplated by the Stock Purchase Agreement.

     Composition of the Calgene Board.  The existing Stockholders Agreement
provides that the composition of the Calgene Board and the manner of selecting
members thereof shall be as follows:

       (a) After March 31, 1996, the Calgene Board shall be comprised of
           nine directors;

       (b) Until the earlier of any time that (i) Monsanto's percentage
           ownership of the outstanding Calgene securities ("Percentage
           Interest") is at least 55% or (ii) Calgene elects to convert
           borrowings made from Monsanto into equity securities of Calgene and
           Monsanto's Percentage Interest is at least 50% after such conversion
           (a "Trigger Event"), the Calgene Board shall consist of two directors
           who include the Chief Executive Officer and a second director
           nominated by a majority of the Company Directors (as hereinafter
           defined) ("Company Management Directors"), three Independent
           Directors (as defined in the Stockholders Agreement) nominated by
           Calgene ("Company Directors") 

                                      -15-
<PAGE>
 
           and four directors nominated by Monsanto (each a "Monsanto
           Director"), at least one of which shall be an Independent Director.

       (c) At and after the occurrence of a Trigger Event, the Calgene Board
           shall be comprised of 11 Directors and Monsanto shall have the right
           to designate two additional directors to the Board; and

       (d) At any time that Monsanto's Percentage Interest is at least 70%,
           (i) Monsanto shall have the right to designate eight Calgene
           Directors, to consist of two Company Management Directors and six
           other directors designated by Monsanto (including at least one
           Independent Director) and (ii) Calgene shall have the right to
           designate three Independent Directors to the Board. At such time as
           Monsanto's Percentage Interest is at least 99%, Monsanto shall have
           the right to designate all of the Calgene Directors.

    The proposed Restated Stockholders Agreement provides that the
composition of the Calgene Board and the manner of selecting members thereof
shall be as follows:

       (a) Until otherwise changed in accordance with the Restated
           Stockholders Agreement, the Board of Directors of Calgene shall be
           comprised of nine Directors consisting of one Company Management
           Director, three Independent Directors and five Directors designated
           by Monsanto, at least one of which shall be an Independent Director.
           With respect to the nominees for election at the Annual Meeting, Mr.
           Kunimoto is the Company Management Director, Messrs. Salquist,
           Vangelos and Palefsky are the Company Directors and Messrs.
           Verfaillie, Fraley, Robson, Hogan and Fortune have been designated by
           Monsanto with Mr. Robson being the Independent Director designated by
           Monsanto.

       (b) The provision in the existing Stockholders Agreement set forth in
           clause (c) above, increasing the Calgene Board to 11 upon the
           occurrence of a Trigger Event and granting to Monsanto the right to
           designate two additional directors was deleted.

       (c) At any time that Monsanto's Percentage Interest is at least
           seventy percent (70%), Calgene shall nominate (i) six directors
           designated by Monsanto which shall consist of one Company Management
           Director and five Monsanto directors (including at least one
           Independent Director) and (ii) three Independent Directors. At such
           time as Monsanto's Percentage Interest is at least ninety-nine
           percent (99%), Calgene shall nominate nine directors designated by
           Monsanto.

    Under the terms of the existing Stockholders Agreement, and unchanged
by the Restated Stockholders Agreement, Calgene shall nominate the following
number of Monsanto designees when the Monsanto Percentage Interest is as set
forth below:

                                      -16-
<PAGE>
 
               Monsanto
               Designees for Nomination
               Monsanto Percentage Interest      to the Calgene Board
               ----------------------------    ------------------------

               less than 40% but at least 20%      3 directors
               less than 20% but at least 10%      2 directors
               less than 10% but at least 5%       1 director
               less than 5%                        none


    In addition, the Restated Stockholders Agreement has changed the
definition of "Trigger Event" so that upon the purchase by Monsanto of the
Additional Shares pursuant to the Stock Purchase Agreement a "Trigger Event"
occurs.

    Under the terms of the Restated Stockholders Agreement the
Retention/Replacement Committee would be eliminated, leaving the Calgene Board
of Directors thereafter responsible for the retention and/or replacement of all
of the executive officers of the Company.

    Registration Rights.  The Stockholders Agreement provides Monsanto and
certain assignees may subject to certain conditions and limitations, require
Calgene, whether or not Calgene proposes to register its Common Stock for sale,
to register with the Securities and Exchange Commission all or part of the
shares held by Monsanto.  The Restated Stockholders Agreement provides that the
Additional Shares acquired by Monsanto pursuant to the Stock Purchase Agreement
shall also be entitled to these registration rights.  Calgene is not required to
effect such a registration prior to September 30, 1998, unless an event of
default has occurred and is continuing under the Credit Agreements.  See
"Certain Transactions - Credit Agreements."

    Anti-Dilution Rights.  If at any time Calgene agrees to sell shares of
Calgene Common Stock or other securities having the right to vote generally in
any election of directors of Calgene (collectively, "Calgene Securities") in a
private or public offering (other than pursuant to Calgene stock option plans),
Monsanto is entitled to notice of such proposed sale and has the right, but not
the obligation, to acquire all or any portion of the Calgene Securities to be
offered for sale sufficient for Monsanto to maintain, after the consummation of
the proposed offering, the same percentage of ownership of Calgene Securities as
Monsanto possessed immediately prior to such offering.  With respect to shares
of Calgene Securities issued pursuant to Calgene's stock option plans, Monsanto
shall have the right to maintain its percentage ownership of issued and
outstanding Calgene Securities by making open market purchases in accordance
with the Stockholders Agreement.  This provision is unchanged by the Restated
Stockholders Agreement.

    Limitations on Monsanto's Ownership of Calgene Securities.

    The existing Stockholders Agreement provides that until September 30,
1998 Monsanto may not increase its Percentage Interest above 49.9% except in
limited circumstances such as:

       (a) conversion of principal and/or interest under the Credit
           Agreements;

       (b) issuance of Calgene Securities in an asset sale by Monsanto
           to Calgene;

       (c) prior to March 31, 1997 a tender offer for 100% of the
           publicly held shares; or

                                      -17-
<PAGE>
 
       (d) on or after March 31, 1997, a tender offer to increase its
           Percentage Interest to 70%, provided if Monsanto increases its
           Percentage Interest to more than 80%, then it has to tender for
           100% of the publicly held shares;

    In both (c) and (d) above, the price must be approved by disinterested
directors and supported by a fairness opinion by an investment banking firm.

    The Restated Stockholders Agreement increases the Percentage Interest
which Monsanto may hold prior to September 30, 1998 to ____% to reflect the
purchase of the Additional Shares pursuant to the Stock Purchase Agreement and
deletes clause (c) above.

    Limitations on Monsanto's Resale of Calgene Securities.  The existing
Stockholders Agreement provides that Monsanto shall not, directly or indirectly,
sell any Calgene securities (other than to an affiliate) except as follows:  (a)
on and after March 31, 1997, Monsanto may sell Calgene securities (i) as part of
a joint venture, merger or sale of all or substantially all of its current Crop
Protection business unit, as such business may be subsequently renamed or
reorganized, or (ii) pursuant to a tender offer by a third party to the
stockholders of Calgene; (b) after September 30, 1998, in addition to the rights
set forth in (a) above, Monsanto may sell Calgene securities (ii) in a
registered public offering pursuant to the registration rights granted to
Monsanto under the Stockholders Agreement; (ii) through sales pursuant to Rule
144 under the Securities Act of 1933 (the "Securities Act"); (iii) through sales
of not more than 10% of the total issued and outstanding Calgene securities to a
Non-Financial Purchaser (as defined in the Stockholders Agreement); or (iv)
through sales to a Financial Purchaser (as defined in the Stockholders
Agreement); (c) after September 30, 1999, in addition to the rights set forth in
(a) and (b) above, Monsanto may sell Calgene securities through a private sale
of 35% or more of the total issued and outstanding Calgene securities to a Non-
Financial Purchaser under circumstances where such third party assumes the
applicable and proportionate rights and obligations of Monsanto under the
Stockholders Agreement and the other transaction agreements; and (d)
notwithstanding the foregoing, at any time, Monsanto may sell Calgene securities
issued to Monsanto upon conversion by Monsanto of principal or accrued interest
under the Credit Agreements after the occurrence of an event of default (see
"Certain Transactions - Credit Agreements").

    This provision will not be changed by the Restated Stockholders
Agreement.

    Approval Required for Certain Actions.  The existing Stockholder
Agreement provides as follows:

       (a) On and after March 31, 1996 until the earlier of a Trigger
           Event or such date on which Monsanto's Percentage Interest is
           less than 25%, a majority of the Calgene Board, including at
           least one Company Director and one Monsanto Management Director,
           shall be required to approve any of the following: (i) the entry
           by Calgene or any of its Affiliates into any merger or
           consolidation or the acquisition by Calgene or any of its
           Affiliates of any business or assets that would constitute more
           than 10% of Calgene's total assets determined on a consolidated
           basis (a "Substantial Part"); (ii) the sale, pledge, grant of
           security interest in, transfer, retirement or other disposal of a
           Substantial Part of Calgene, except pursuant to a security
           interest granted in connection with borrowings permitted under
           subsection (iv) below or the pledge or granting of a security
           interest in certain intangible property as further described in
           the Stockholders Agreement; (iii) any dividend by or return of
           capital by Calgene or Gargiulo, Inc. (formerly Tomato Investment
           Associates, Inc.) (other than such distributions by Gargiulo,
           Inc. to Calgene as are necessary for Calgene to timely perform
           its obligations under the Gargiulo Credit Facility Agreement);
           (iv) any incurrence or assumption, in the aggregate, by Calgene,
           any of its 
            
           

                                      -18-
<PAGE>
 
           affiliates or any combination thereof, of any
           indebtedness for borrowed money at any time outstanding exceeding
           in the aggregate (determined on a consolidated basis) the greater
           of (A) $15 million, increasing by $5 million on each July 1
           commencing July 1, 1996, plus amounts secured by inventory and/or
           receivables for seasonal working capital lines and indebtedness
           incurred to acquire property, plant or equipment and secured by
           the acquired asset, minus amounts outstanding under the Calgene
           Credit Facility Agreement, or (B) the amounts set forth in the
           Calgene Operating Plan (as defined in the Stockholders
           Agreement), provided that loans under the Gargiulo Credit
           Facility Agreement shall not be counted in this limitation; (v)
           the repurchase or redemption of any Calgene securities, other
           than from employees upon termination of employment or service;
           (vi) the establishment of any new committees of the Calgene Board
           or new or revised delegations of Calgene Board authority to any
           Calgene Board committee or changes or revisions to general
           delegations of authority to officers or other persons for
           categories of expenditures; (vii) the adoption of or amendment to
           any benefit or incentive plans of Calgene or any of its
           Affiliates which would increase the annual cost thereof by more
           than fifteen percent (15%) from the prior fiscal year or any
           adoption of, or amendment to, any stock option plan; (viii) the
           election, appointment or removal of the Chief Executive Officer,
           Chief Operating Officer or Chief Financial Officer of Calgene and
           its successors and the establishment of its annual or long-term
           compensation level and benefits (other than agreements in effect
           at the Effective Time); provided, however, that Monsanto shall
           have the right to select the Chief Technical Officer of Calgene
           and a controller reporting to the Chief Financial Officer of
           Calgene; (ix) approval of the Operating Plan and Strategic Plan
           (each as defined in the Stockholders Agreement) of Calgene and
           its Affiliates, as well as the annual operating plan and long-
           term strategic plan for the Gargiulo business, to be submitted to
           the Calgene Board annually for approval, and any material changes
           thereto; (x) any transaction between Calgene (and its
           Affiliates), on the one hand, and its directors, officers or
           employees, on the other hand, which is not in the normal course
           of business; (xi) any modification of the transaction agreements;
           (xii) any amendment of the By-Laws or Certificate of Incorporation of
           Calgene or Gargiulo, Inc.; (xiii) the issuance of additional Calgene
           securities (other than warrants for the purchase of Calgene
           securities) in excess of 4,000,000 shares of Calgene Common Stock in
           any two-year period to a third party, other than pursuant to plans
           referred to in subsection (vii) above or the issuance of any warrants
           for the purchase of Calgene securities; (xiv) the sale or licensing
           by Calgene or any of its Affiliates of certain intangible property,
           as further described in the Stockholders Agreement, or any other
           intangible property for consideration (other than royalties
           contingent on future sales) exceeding $5 million in the aggregate
           (determined on a consolidated basis) per transaction or per series of
           related transactions; (xv) new fixed capital investments, capital
           leases or noncancellable operating leases by Calgene and its
           Affiliates having annual payments in the aggregate (determined on a
           consolidated basis) exceeding the aggregate amount set forth in the
           Operating Plan; (xvi) matters relating to Gargiulo, Inc. covered in
           Article 5 of the Stockholders Agreement, including, without
           limitation, any changes in the composition of the Gargiulo Board of
           Directors; (xvii) any press release which mentions or directly or
           indirectly refers to Monsanto, except as required by law and where
           Calgene Board approval cannot be obtained in a timely manner; (xviii)
           the initiation, settlement or termination of any suit or proceeding

                                      -19-
<PAGE>
 
           concerning intellectual property, any other matter which could have
           an adverse public affairs effect upon Monsanto or the filing of any
           insolvency or bankruptcy proceeding by or on behalf of Calgene or any
           of its Affiliates; or (xix) the removal or election of the directors,
           subject to the terms of the Stockholders Agreement, of Gargiulo, Inc.

       (b) After a Trigger Event and until the earlier of (i) March 31,
           1999 or (ii) such time as Monsanto's Percentage Interest is at
           least seventy percent (70%), a majority of the Calgene Board,
           including at least two Company Directors, shall be required to
           approve any of the following:  except as provided in the
           Stockholders Agreement, the matters set forth in clauses (i),
           (ii), (vi), (viii), (ix) and (xi) of paragraph (a) above; or (ii)
           any transaction between Calgene (and its Affiliates) and Monsanto
           or any Affiliate of Monsanto.

       (c) From and after the occurrence of both (i) a Trigger Event and
           (ii) March 31, 1999, and until Monsanto's Percentage Interest is
           at least 99%, neither Monsanto nor any of Affiliates shall enter
           into any transaction with Calgene or any of its Affiliates
           without the approval of at least two Company Directors.

    The Restated Stockholders Agreement will delete clause (a)(xvi) above
because Article 5 of the Stockholders Agreement referred to therein, which
contained several provisions relating to the operations of Gargiulo, Inc.
(formerly Tomato Investment Associates, Inc.) a wholly owned subsidiary of
Calgene, will also be deleted.

    Further, the amendment to the Stockholders Agreement changes the
definition of "Trigger Event" so that upon the purchase by Monsanto of the
Additional Shares a "Trigger Event" occurs. Accordingly, after the purchase by
Monsanto of the Additional Shares, clause (b) above, not clause (a), will be
applicable.

CERTIFICATE OF AMENDMENT

    The amendments to Calgene's Certificate of Incorporation reflected in
the proposed Certificate of Amendment are to (i) reflect the amendments to the
provisions in the Stockholders Agreement as reflected in the Restated
Stockholders Agreement and described in the "Composition of the Calgene Board"
and "Approval Required for Certain Actions," and (ii) increase the authorized
shares of Calgene from 80,000,000 shares to 100,000,000 shares.  A copy of the
Certificate of Amendment is appended to this Proxy Statement as Exhibit B.

    THE FOREGOING IS A BRIEF SUMMARY OF CERTAIN PROVISIONS OF THE STOCK
PURCHASE AGREEMENT, THE RESTATED STOCKHOLDERS AGREEMENT AND CERTIFICATE OF
AMENDMENT.  THE RESTATED STOCKHOLDERS AGREEMENT AND CERTIFICATE OF AMENDMENT ARE
ATTACHED HERETO AS EXHIBITS A AND B, RESPECTIVELY, AND INCORPORATED BY REFERENCE
HEREIN.

                              CERTAIN TRANSACTIONS

SUMMARY OF EXISTING AGREEMENTS WITH MONSANTO

    Reorganization Agreement.  On October 13, 1995, the Company and
    ------------------------                                       
Monsanto entered into an Agreement and Plan of Reorganization ("Reorganization
Agreement") and certain other agreements whereby Monsanto contributed all of the
outstanding shares of capital stock of Tomato Investment Associates, Inc., a
wholly-owned subsidiary of Monsanto ("TIA"), whose principal asset was the
entire 

                                      -20-
<PAGE>
 
equity interest in Gargiulo, L.P., $30 million in cash and certain technology
licenses in exchange for a 49.9% equity interest in the Company. In connection
with the Reorganization Agreement, a total of 30,146,114 shares of Common Stock
of the Company were issued to Monsanto. The Reorganization Agreement was
approved by the stockholders of the Company on March 25, 1996. On March 31, 1996
(the "Effective Time"), the Company and Monsanto consummated the transactions
contemplated by the Reorganization Agreement which included entering into the
agreements discussed below. Subsequent to the Effective Date, Gargiulo L.P. was
merged into TIA and TIA changed its name to "Gargiulo, Inc."

    Stockholders Agreement.  On March 31, 1996, the Company and Monsanto
    ----------------------                                              
entered into a Stockholders Agreement (the "Stockholders Agreement").  The
Stockholders Agreement and the proposed amendments thereto are summarized herein
under "Proposal No. 2 - Approval of Transaction with Monsanto - Summary of 
Existing Stockholders Agreement and Proposed Amendments."

  Credit Agreements
  -----------------

    Calgene Credit Facility Agreement

    On March 31, 1996, Monsanto and Calgene entered into the Calgene Credit
Facility Agreement pursuant to which Monsanto shall, during the Commitment
Period (as hereinafter defined), and subject to the terms and conditions
contained therein, make, at the request of Calgene, three consecutive one-year
loans of up to $15 million each (each a "Calgene Loan" and together the "Calgene
Loans"), collectively totalling not more than $45,000,000.  At no time shall the
outstanding principal of all Calgene Loans exceed $15 million.  Prior to the
occurrence of an Event of Default (as defined in the Calgene Credit Facility
Agreement), Calgene may borrow, repay and reborrow under each Calgene Loan, each
such borrowing or reborrowing being an "Advance."  The "Commitment Period" began
on March 31, 1996 and ends on the earlier of September 30, 1998, or such earlier
time that Monsanto terminates its obligations to make further Advances under the
Calgene Credit Facility Agreement.  The Calgene Loans made pursuant to the
Calgene Credit Facility Agreement are to be secured by the joint and several
guaranty of the subsidiaries of Calgene.

    Prior to the occurrence of an Event of Default, the Calgene Loans bear
interest at the per annum rate equal to 2.00% above Citibank's published prime
rate (the "Calgene Base Rate"), and following an Event of Default at the per
annum rate equal to 3.00% above the Calgene Base Rate.  During the continuance
of an Event of Default, Calgene shall have no right to obtain any new Advances
under this Agreement.  The Calgene Loans may be prepaid in whole or in part at
any time after giving at least three days' prior written notice to Monsanto.

    In lieu of repayment of outstanding principal and accrued interest on each
Calgene Loan, Calgene, subject to Monsanto's right to require Calgene to sell
shares and pay cash, as provided below, may elect to convert all or any portion
of the principal and accrued interest due under the applicable Calgene Loan (the
"Conversion Amount") into shares of Calgene Common Stock at the average of the
closing market price for such shares during the thirty trading days immediately
preceding the applicable maturity date for such Calgene Loan.

    Monsanto may, in its sole discretion and within five business days after
its receipt of notice from Calgene that Calgene intends to exercise Calgene's
rights to convert the Conversion Amount, give written notice to Calgene stating
that (i) all or any part of the Conversion Amount shall be payable in cash (the
"Alternative Conversion Amount"), (ii) Calgene shall, at its expense, sell
publicly such number of shares of its common stock as Monsanto would have
received if the Alternative Conversion Amount had been converted as described
above and (iii) the net proceeds of such sale shall be paid by Calgene to
Monsanto in full payment and satisfaction of such Alternative Conversion Amount.

                                      -21-
<PAGE>
 
    Upon any such conversion, the Conversion Amount shall first be applied to
reduce the accrued interest due on the applicable Calgene Loan as of the
applicable maturity date, and any remaining portion of the Conversion Amount
shall be applied to reduce the principal due on such Calgene Loan.  In any
event, on each annual Maturity Date (as defined in the Calgene Credit Facility
Agreement), all outstanding principal and accrued interest not converted by
Calgene into shares of Calgene Common Stock shall be repaid in full to Monsanto.

    Upon the occurrence and during the continuation of an Event of Default, for
a period of thirty (30) days from the occurrence of the Event of Default,
Calgene, subject to Monsanto's right to require Calgene to sell shares and pay
cash, as described above, may similarly elect to convert all or any portion of
the principal and accrued interest under any outstanding Calgene Loan into
shares of Calgene Common Stock. If Calgene does not elect to exercise its
conversion rights upon such an Event of Default, Monsanto may, in addition to
its other remedies, elect to convert all or a portion of the remaining principal
and accrued interest under such Calgene Loan into shares of Calgene Common Stock
at the average of the closing market prices for such shares during the thirty
days preceding such Event of Default.  In no event, however, shall Monsanto
elect to convert principal and accrued interest into more than 3,000,000 shares
of Calgene Common Stock (as such number is adjusted for stock dividends, stock
splits and similar events affecting holders of Calgene's common stock).

    The obligation of Monsanto to provide Advances is subject to the
fulfillment of certain conditions, including, among others: (i) the continued
accuracy of all representations and warranties made by Calgene and its
subsidiaries; (ii) the compliance with all covenants contained in the Calgene
Credit Facility Agreement; (iii) no event shall have occurred which would
constitute an Event of Default or Potential Event of Default (as defined in the
Calgene Credit Facility Agreement); or (iv) there shall not have occurred any
circumstance which could reasonably be expected to have a material adverse
effect on (A) the business, assets, operations or financial condition of Calgene
and its subsidiaries, taken as a whole, or (B) the ability of the Company and
its subsidiaries to perform their obligations under the Calgene Credit Facility
Agreement.

    The covenants contained in the Calgene Credit Facility Agreement require
Calgene to maintain a minimum consolidated net worth of not less than $10
million and a minimum consolidated working capital of not less than $5 million.
The Calgene Credit Facility Agreement also requires that Calgene and its
subsidiaries meet certain specified financial ratios, including a ratio of total
long-term liabilities to net worth and a current ratio.  In addition, the
Calgene Credit Facility Agreement imposes a number of limitations on Calgene
with respect to future acquisitions, liens, mergers and the sale of assets,
loans and investments, guaranties, capital expenditures, the payment of
dividends and the incurrence of indebtedness.  The existence of these covenants
could limit Calgene's ability to finance the growth of its existing operations
if cash flows were to decrease substantially or if expenses were to increase
substantially. These covenants would also limit Calgene's ability to engage in
additional acquisitions that would significantly increase the ratio of long-term
indebtedness to net worth following such acquisitions.  The failure of Calgene
to satisfy these covenants would cause an Event of Default which could have a
material adverse effect on its business and results of operations.  Calgene is
not in compliance with certain financial covenants contained in the Calgene
Credit Facility Agreement.  Monsanto has agreed to grant Calgene a limited
waiver with respect to such non-compliance only as to the initial Advance which
matures March 31, 1997, provided Calgene first makes all reasonable efforts to
obtain any further necessary funds from its existing senior lenders.

    All of the Calgene Loans shall be subordinated and subject in right of
payment to the prior payment in full of a certain senior indebtedness of Calgene
as more fully described in the Calgene Credit Facility Agreement.  No payment on
account of principal or interest on the Calgene Loans shall be made if at the
time of such payment or immediately after giving the effect thereto: (i) there
shall exist a default in any payment with respect to any such senior
indebtedness or (ii) there shall have occurred an event of 

                                      -22-
<PAGE>
 
default (other than a default in the payment of amounts due thereon) with
respect to any such senior indebtedness.

    As of August 31, 1996, there was no outstanding balance of principal and
interest under the Calgene Credit Facility Agreement.

       Gargiulo Credit Facility Agreement

    On March 31, 1996, Monsanto and Calgene entered into the Gargiulo Credit
Facility Agreement pursuant to which Monsanto shall, during the Commitment
Period (as hereinafter defined), and subject to the terms and conditions
contained therein, make available to Calgene a revolving credit facility of up
to $40 million (the "Gargiulo Loan").

    The Gargiulo Loan has been used to acquire Collier Farms and to support the
braned tomato strategy of Gargiulo as determined by the Gargiulo Board of
Directors (other than amounts used to finance the acquisition of Collier Farms).
Prior to the occurrence of an Event of Default (as defined in the Gargiulo
Credit Facility Agreement), Gargiulo may borrow, repay and reborrow, each such
borrowing or reborrowing being an "Advance."  In order to obtain an Advance from
Monsanto under the Gargiulo Credit Facility Agreement, Gargiulo must provide
documentation reasonably acceptable to Monsanto verifying that Gargiulo has
reached certain milestones and achieved certain goals as set forth therein.  The
maximum amount of each Advance is subject to certain limitations based upon such
milestones and goals. The "Commitment Period" began on March 31, 1996 and ends
on the earlier of the fourth anniversary or such earlier time that Monsanto
terminates its obligations to make further Advances.  The Gargiulo Loan is
secured by the joint and several guaranty of the subsidiaries of Calgene.

    Prior to the occurrence of an Event of Default, the Gargiulo Loan shall
bear interest at the per annum rate equal to 2.00% above Citibank's published
prime rate (the "Gargiulo Base Rate"), and following an Event of Default at the
per annum rate equal to 3.00% above the Gargiulo Base Rate.  During the
continuance of an Event of Default, Calgene shall have no right to obtain any
new Advances.  The Gargiulo Loan may be prepaid in whole or in part at any time
after giving at least three days' prior written notice to Monsanto.

    The Gargiulo Loan is payable, unless extended as described below, in one
payment on the fourth anniversary of the Effective Time (the "Maturity Date") in
an amount equal to the lesser of (i) the Repayment Portion of the Cumulative
Free Cash Flow (as defined in the Gargiulo Credit Facility Agreement) of
Gargiulo from the Effective Time to the Maturity Date and (ii) the amount of the
outstanding principal and accrued interest on the Gargiulo Loan.  "Repayment
Portion" means the sum of 20% of the first $10 million of Cumulative Free Cash
Flow, 50% of the next $10 million and 80% of the remaining balance.  In the
event that the Repayment Portion is not sufficient to pay all of the then
outstanding principal and accrued interest at the Maturity Date, the maturity
date with respect to the unpaid amount of outstanding principal and interest
shall be extended to the sixth anniversary of the Effective Time (the "Extended
Maturity Date").  In the event the Repayment Portion of the Cumulative Free Cash
Flow (less amounts previously paid) is not sufficient to pay the then
outstanding principal and accrued interest at the Extended Maturity Date,
Calgene shall pay Monsanto such lesser amount and Monsanto, at its sole option,
may do any one or combination of the following: (i) convert all or any portion
of the then outstanding principal and accrued interest into shares of Calgene
Common Stock at the average of the closing market price for such shares during
the thirty trading days immediately preceding the date of such conversion, (ii)
further extend the Final Maturity Date (as defined in the Gargiulo Credit
Facility Agreement) upon the same terms as are contained in the Gargiulo Credit
Facility Agreement, or (iii) as to any unpaid amount which is not converted
under clause (i) or for which payment is not extended pursuant to clause (ii),
cause Calgene to sell publicly that number of shares of Calgene Common Stock as

                                      -23-
<PAGE>
 
Monsanto would have received if such amount has been converted under clause (i)
above with the net proceeds of such sale being delivered to Monsanto in full
payment and satisfaction of such amount.

    Upon the occurrence and during the continuation of an Event of Default,
Monsanto may, in addition to its other remedies, similarly elect to convert all
or any portion of the principal and accrued interest under the Gargiulo Loan
(the "Gargiulo Conversion Amount") into shares of Calgene Common Stock at the
average of the closing market prices for such shares during the thirty days
preceding such Event of Default.  In no event, however, shall Monsanto elect to
convert principal and accrued interest into more than 8,000,000 shares of
Calgene Common Stock (as such number is adjusted for stock dividends, stock
splits and similar events affecting holders of Calgene's common stock).  Upon
any such conversion, the Gargiulo Conversion Amount shall first be applied to
reduce the accrued interest due on the Gargiulo Loan, and any remaining portion
of the Gargiulo Conversion Amount shall be applied to reduce the principal due
on such Gargiulo Loan.

    The obligation of Monsanto to provide Advances is subject to the
fulfillment of certain conditions, including, among others: (i) the continued
accuracy of all representations and warranties made by Calgene and its
subsidiaries; (ii) the compliance with all covenants contained in the Gargiulo
Credit Facility Agreement; (iii) no event shall have occurred which would
constitute an Event of Default or Potential Event of Default (as defined in the
Gargiulo Credit Facility Agreement); or (iv) there shall not have occurred any
circumstance which could reasonably be expected to have a material adverse
effect on (A) the business, assets, operations or financial condition of Calgene
and its subsidiaries, taken as a whole or (B) the ability of the Company and its
subsidiaries to perform their obligations under the Gargiulo Credit Facility
Agreement.

    The covenants contained in the Gargiulo Credit Facility Agreement require
Calgene to maintain a minimum consolidated net worth of not less than $10
million and a minimum consolidated working capital of not less than $5 million.
The Gargiulo Credit Facility Agreement also requires that Calgene and its
subsidiaries meet certain specified financial ratios, including a ratio of total
long-term liabilities to net worth and a current ratio.  In addition, the
Gargiulo Credit Facility Agreement imposes a number of limitations on Calgene
and each of its subsidiaries with respect to future acquisitions, liens, mergers
and the sale of assets, loans and investments, guaranties, capital expenditures,
the payment of dividends and the incurrence of indebtedness.  The existence of
these covenants could limit Calgene's ability to finance the growth of its
existing operations if cash flows were to decrease substantially or if expenses
were to increase substantially.  These covenants would also limit Calgene's
ability to engage in additional acquisitions that would significantly increase
the ratio of long-term indebtedness to net worth following such acquisitions.
The failure of Calgene to satisfy these covenants would cause an Event of
Default which could have a material adverse effect on its business and results
of operations.  Calgene is not in compliance with certain financial covenants
contained in the Gargiulo Credit Facility Agreement.  Calgene intends to seek a
waiver from Monsanto with respect to such non-compliance.

    The Gargiulo Loan is to be subordinated and subject in right of payment to
the prior payment in full of certain senior indebtedness of Calgene as more
fully described in the Gargiulo Credit Facility Agreement.  No payment on
account of principal or interest on the Gargiulo Loan shall be made if at the
time of such payment or immediately after giving the effect thereto, (i) there
shall exist a default in any payment with respect to any such senior
indebtedness or (ii) there shall have occurred an event of default (other than a
default in the payment of amounts due thereon) with respect to any such senior
indebtedness.

    As of August 31, 1996, the outstanding balance of principal and interest
under the Gargiulo Credit Facility Agreement was $______________.

    License Agreements

                                      -24-
<PAGE>
 
    As part of the Initial Monsanto Transaction in March 1996, Monsanto
contributed certain technology licenses to Calgene pursuant to various license
agreements and letter agreements.  The technologies underlying the License
Agreements are summarized below.

    ACC Synthase and ACC Deaminase.  ACC is a precursor of ethylene, a plant
growth regulator that induces ripening in certain fruits.  By reducing the
amount of ACC available for conversion into ethylene, the ripening process can
be delayed.  Control of the ripening process may enable Calgene to improve the
efficiency of its tomato production operations.  Calgene will be granted non-
exclusive, perpetual, royalty-free rights to the ACC synthase and ACC deaminase
genes for use in certain produce crops and shall be able to practice under
Monsanto's ACC Synthase license from the USDA.

    Fruit-specific Promoters.  Promoters control the expression of genes in
each plant cell.  In order for certain genes to function in a beneficial manner,
expression of these genes must be restricted to certain parts of the plant.
Fruit-specific promoters provide a means of limiting gene expression to the
fruit.  For example, these promoters may be useful in regulating carbohydrate
metabolism (e.g., sugar content) in ripening fruits such as tomatoes and
strawberries.  Calgene has been granted non-exclusive, perpetual, royalty-free
rights to certain fruit-specific promoters for use in certain produce crops.

    Virus Resistance Genes.  Virus infection is known to significantly reduce
the yields of certain crops, including tomatoes.  Monsanto has developed methods
of interfering with viral replication in engineered plants, which slows the rate
and degree of infection, and reduces the yield loss resulting from the
infection. Calgene has been granted non-exclusive, perpetual, royalty-free or
royalty-bearing rights to certain aspects of Monsanto's patent estate related to
the engineering of virus resistance into certain produce crops.

    FAD 3 Gene.  The FAD 3 gene controls the relative amount of polyunsaturated
fatty acids found in plant oils, including canola oil.  Calgene believes that
reducing the expression of the FAD 3 gene in engineered canola plans may result
in an oil with reduced linoleic and linolenic acid content.  Such an oil would
be a superior cooking oil, as well as a superior raw material for the production
of margarine and shortening.  Calgene has been granted exclusive, perpetual,
royalty-bearing rights to the FAD 3 gene for use in certain oilseed crops.

    Insect Resistance Gene.  Monsanto has modified genes from a soil
microorganism called Bacillus thurengiensis ("B.t.") the encode proteins that
are toxic to certain insects.  Use of insecticides to control insects is a major
cost in the production of tomatoes.  Calgene has been granted non-exclusive,
perpetual, royalty-free rights to Monsanto's B.t. patent estate for use in
certain produce crops.

    ADP Glucose Pyrophosphorylase ("ADPGPP") Gene.  The ADPGPP gene is a
bacterial gene involved in starch biosynthesis.  By expression of this gene in
plants, the starch and/or sugar content of plants can be increased.  This may
improve the flavor or sweetness of produce crops such as tomatoes or
strawberries.  Calgene has been granted non-exclusive, perpetual, royalty-free
rights to Monsanto's patent estate related to ADPGPP for use in certain produce
crops.  Monsanto and Calgene are parties to an interference at the United States
Patent and Trademark Office relating to the ADPGPP gene.

    Oil Modification Technology.  Monsanto has certain patent rights and know-
how related to the production of plants with altered oil compositions.  By
modifying oil composition it may be possible to provide temperate sources of
certain tropical oils and the production of novel oil compositions.  The
Monsanto oil modification genes include sucrose phosphorylase, cytochrome b5 and
PEP carboxylase. Calgene has been granted non-exclusive, perpetual, royalty-free
rights under Monsanto's patents and know-how for use in certain oilseed crops.

    Insect Protected Cotton Direct Grower Licensing Agreement

                                      -25-
<PAGE>
 
    Calgene has entered into an agreement with Monsanto under which Calgene
will participate in the direct licensing of Monsanto's B.t. technology to cotton
growers.  Under the terms of this agreement, Monsanto has granted to Calgene a
non-exclusive, royalty-free U.S. license to use Monsanto's B.t. technology in
Calgene's cottonseed products.  Subject to the issuance of a Monsanto patent
that covers the B.t. gene that is currently being utilized in Calgene's
cottonseed product development program, Calgene would be obligated under
applicable patent law to end use of its current B.t. gene and is permitted under
such agreement to incorporate Monsanto's B.t. gene into its product development
program over a four-year period.

    Monsanto intends to enter into license agreements directly with cotton
growers.  Under the terms of these agreements, cotton growers would obtain a
one-time right to purchase a specified number of units of cottonseed containing
Monsanto's B.t. gene in return for the payment of a license fee.  Monsanto has
agreed to pay to Calgene a specified percentage of the net license fees received
from licensed growers who subsequently purchase Calgene's cottonseed products
containing Monsanto's B.t. gene.  The material terms of Calgene's agreement
shall be modified to reflect any more favorable terms that may be granted to any
other cottonseed company that may participate in the direct licensing program.


                                 PROPOSAL NO. 3

            INCREASE IN AUTHORIZED NUMBER OF SHARES OF COMMON STOCK

    The Company currently has authorized 80,000,000 shares of Common Stock.  As
of August 31, 1996, there were 60,443,115 shares of Common Stock outstanding and
3,673,996 additional shares of Common Stock reserved for issuance upon exercise
of outstanding stock options.  After giving effect to the purchase of the
Additional Shares by Monsanto, only 9,632,889 shares will be available for
further issuance.  Accordingly, the Board has adopted an amendment to the
Certificate of Incorporation, subject to stockholder approval, to increase its
authorized Common Stock to 100,000,000 shares.  The affirmative vote of the
holders of a majority of the shares of Calgene Common Stock outstanding on the 
Record Date is required for approval of this amendment to the Certificate of
Incorporation.

    The Board of Directors recommends a vote FOR the proposed increase in
authorized Common Stock.

                                 PROPOSAL NO. 4

              CONFIRMATION OF APPOINTMENT OF INDEPENDENT AUDITORS

    On May 21, 1996, the Company announced that it was changing its fiscal year
end from June 30 to December 31.  The Board of Directors has selected Ernst &
Young LLP as the Company's independent public accountants for the transition
period of July 1, 1996 through December 31, 1996 and for the fiscal year ending
December 31, 1997 and recommends that the stockholders confirm such selection.
Confirmation will require the affirmative vote by holders of a majority of
shares present or represented by proxy and entitled to vote on the matter.  In
the event that confirmation fails to receive the required majority vote, the
Board of Directors will reconsider its selection.

    Ernst & Young LLP has audited the Company's annual financial statements
since the fiscal year ended September 30, 1982.  Representatives of Ernst &
Young LLP are expected to be present at the Annual Meeting with the opportunity
to make a statement if they desire to do so, and are expected to be available to
respond to appropriate questions.

                    STOCKHOLDER PROPOSALS FOR ANNUAL MEETING

                                      -26-
<PAGE>
 
    Proposals that are intended to be presented by stockholders of the Company
at the 1997 Annual Meeting must be received by the Company no later than
_______________ in order that they may be potentially eligible to be included in
the Company's proxy statement and from of proxy relating to that meeting.

                           INCORPORATION BY REFERENCE

    The Company hereby incorporates by reference into this Proxy Statement its
Annual Report on Form 10-K for the fiscal year ended June 30, 1996 and all
reports filed by the Company with the Securities and Exchange Commission
pursuant to Section 13(a) of the Securities Exchange Act of 1934 after the date
hereof and prior to the date of the Annual Meeting.

                                 OTHER MATTERS

    The Company knows of no other matters to be submitted to the meeting.  If
any other matters properly come before the meeting, it is the intention of the
persons named in the accompanying form of proxy to vote the shares they
represent as the Board of Directors may recommend.

                                      -27-
<PAGE>
 
THE COMPANY WILL MAIL WITHOUT CHARGE TO ANY STOCKHOLDER UPON WRITTEN REQUEST A
COPY OF THE ANNUAL REPORT ON FORM 10-K, INCLUDING THE FINANCIAL STATEMENTS,
SCHEDULES AND A LIST OF EXHIBITS.  REQUESTS SHOULD BE SENT TO THE CORPORATE
SECRETARY, CALGENE, INC., 1920 FIFTH STREET, DAVIS, CALIFORNIA 95616.

                                      -28-
<PAGE>
 
PROXY                                                                      PROXY

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                                 CALGENE, INC.

                      1996 ANNUAL MEETING OF STOCKHOLDERS

                         To be held on October 31, 1996



        The undersigned stockholder of Calgene, Inc. ("Calgene") hereby
   acknowledges receipt of the Notice of Annual Meeting of Stockholders and
   Proxy Statement for the 1996 Annual Meeting of Stockholders of Calgene, Inc.
   to be held on October 31, 1996, and hereby appoints Lloyd M. Kunimoto and
   Michael J. Motroni, and each of them, proxy and attorney-in-fact, with full
   power of substitution, on behalf and in the name of the undersigned to
   represent the undersigned at such meeting and at any continuations or
   adjournments thereof, and to vote all shares of Common Stock which the
   undersigned would be entitled to vote if then and there personally present,
   on the matters set forth on the reverse side.

                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE
<PAGE>
 
   1.  To elect directors of the Company.

   NOMINEES:  Patrick J. Fortune, Robert T. Fraley, Michael R. Hogan, Lloyd
   Kunimoto, Howard D. Palefsky, John E. Robson, Roger H. Salquist, Allen J.
   Vangelos, Hendrik A. Verfaillie.

   For  [_]                Withheld  [_]

   [_] ___________________  For all nominees except vote withheld
                            from nominee(s) noted on line above.

   2.  To approve the Stock Purchase Agreement dated ______________, 1996
   ("Stock Purchase Agreement") between Calgene and Monsanto Company, a Delaware
   Company ("Monsanto") pursuant to which (i) Calgene would issue 6,250,000
   shares of Common Stock to Monsanto for $8.00 per share for an aggregate
   purchase price of $50 million, thereby increasing Monsanto's ownership
   interest in shares of Calgene Common Stock from 49.9% to approximately 54.6%
   (without giving effect to the exercise of outstanding options and warrants),
   (ii) Monsanto and Calgene would enter into a Restated Stockholders Agreement
   ("Restated Stockholders Agreement") amending and restating the Stockholders
   Agreement dated March 31, 1996 ("Stockholders Agreement") as more fully
   described in the Proxy Statement, and (iii) the Company's Restated
   Certificate of Incorporation would be amended to reflect the amendments to
   the Stockholders Agreement contemplated by the Restated Stockholders
   Agreement (the foregoing transactions are hereinafter collectively referred
   to as the "Monsanto Transaction").
   
   For  [_]                    Against  [_]                      Abstain  [_]
 
   3.  To increase the authorized number of shares of Common Stock from
   80,000,000 to 100,000,000 shares.

   For  [_]                    Against  [_]                      Abstain  [_]

   4.  To confirm the appointment of Ernst & Young LLP as the independent
   auditors of the Company through the fiscal year ending December 31, 1997.

   For  [_]                    Against  [_]                      Abstain  [_]

   THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO CONTRARY DIRECTION IS
   INDICATED, WILL BE VOTED FOR THE PROPOSALS SET FORTH ABOVE AND AS THE
                            ---   
   PROXYHOLDERS DEEM ADVISABLE ON SUCH OTHER MATTERS AS MAY COME BEFORE THE
   MEETING.
   
              MARK HERE FOR ADDRESS CHANGE AND NOTE BELOW                 [_]

   (This Proxy should be marked, dated, signed by the stockholder(s) exactly as
   his or her name appears hereon, and returned promptly in the enclosed
   envelope.  Persons signing as officers or in a fiduciary capacity should so
   indicate.  If shares are held by joint tenants or as community property, both
   should sign.)

   Signature _______________________  Date________________

   Signature _______________________  Date________________

<PAGE>
                                                                       EXHIBIT A
 
                               CALGENE II, INC.

                                      AND

                               MONSANTO COMPANY

                             AMENDED AND RESTATED

                            STOCKHOLDERS AGREEMENT
                            
<PAGE>
 
                               TABLE OF CONTENTS

ARTICLE 1  Effect of this Agreement.......................................   1

     1.1   Effect of this Agreement.......................................   1

ARTICLE 2  Compliance with Securities Act.................................   2

     2.1   Certain Definitions............................................   2
     2.2   Requested Registration.........................................   7
     2.3   Company Registration...........................................  10
     2.4   Expenses of Registration.......................................  12
     2.5   Registration procedures........................................  12
     2.6   Indemnification................................................  14
     2.7   Information by Holder..........................................  16 
     2.8   Rule 144 Reporting.............................................  16
     2.9   Transfer of Registration Rights................................  17
     2.10  Limitations on Subsequent Registration Rights..................  17
     2.11  Termination of Registration Rights.............................  17
     2.12  "Market Stand-off" Agreement...................................  18 
        
ARTICLE 3  Anti-Dilution Rights and Limitations on Owner..................  18

     3.1   Anti-Dilution Rights...........................................  18
     3.2   Private Offering...............................................  18
     3.3   Public Offering................................................  19
     3.4   Limitations....................................................  19
     3.5   Open Market Purchases to Maintain Ownership Percentage.........  20
     3.6   Limitations on Holder's Ownership..............................  20
     3.7   Limitations on Holder's Resale of Company Securities...........  21
        
ARTICLE 4  Company and Calgene Corporate Governance.......................  22

     4.1   Composition of the Board of Directors and Calgene Board........  22
     4.2   Solicitation and Voting of Shares..............................  25
     4.3   Committees.....................................................  26
     4.4   Approval Required for Certain Actions..........................  27
     4.5   Enforcement of this Agreement..................................  30
     4.6   Certificate of Incorporation and By-laws.......................  30
     4.7   Advisors.......................................................  31
     4.8   Injunctive Relief..............................................  31

ARTICLE 5  Governance of Gargiulo.........................................  31
<PAGE>
 
ARTICLE 6  Miscellaneous.................................................  31

     6.1   Governing Law.................................................  31
     6.2   Successors and Assigns........................................  31
     6.3   Entire Agreement; Amendment...................................  31
     6.4   Notices.......................................................  32
     6.5   Delays or Omissions...........................................  32
     6.6   Counterparts..................................................  33
     6.7   Severability..................................................  33
     6.8   Stock Legends.................................................  33
     6.9   [This section intentionally left blank.]......................  33
     6.10  Audits Consultants and Inspections............................  33
     6.11  No Third Party Beneficiaries..................................  34
     6.12  Sections and Articles.........................................  34
     6.13  Headings......................................................  34
<PAGE>
 
                  AMENDED AND RESTATED STOCKHOLDERS AGREEMENT
                  -------------------------------------------

AGREEMENT made as of the 31st day of March, 1996, by and between Calgene II,
Inc., a Delaware corporation, having its principal place of business at 1920
Fifth Street, Davis, California 95616 (the "Company"), and Monsanto Company, a
Delaware corporation, having its principal place of business at 800 North
Lindbergh Boulevard, St. Louis, Missouri 63167 ("Monsanto"), as amended as of
______________, 1996.

WHEREAS, Calgene, Inc., a Delaware corporation ("Calgene"), and Monsanto have
entered into an Agreement and Plan of Reorganization, dated as of October 13,
1995 (the "Reorganization Agreement"), and certain other Transaction Agreements
(as defined in the Reorganization Agreement) whereby Monsanto has acquired
shares of the Company's common stock, par value $.001 per share ("Common Stock")
and may acquire additional shares of Common Stock;

WHEREAS, the Company and Monsanto have agreed that the Company shall, at the
request of a Holder (as hereafter defined), register under the Securities Act of
1933, as amended (the "Securities Act"), and register or qualify under any
applicable state securities or blue sky laws the Common Stock of the Company
acquired or to be acquired by Holder so as to permit a Holder to sell such
Common Stock in the public markets; and

WHEREAS, the Company and Monsanto have agreed on certain restrictions and
obligations with respect to the management and operation of the Company, Calgene
and Tomato Investment Associates, Inc., a Delaware corporation ("Tomato
Associates").

NOW, THEREFORE, in consideration of the premises and the mutual covenants and 
conditions herein contained, the Company and Monsanto hereby agree as follows:


                                   ARTICLE 1
                           Effect of this Agreement
                           ------------------------

1.1  Effect of this Agreement. Effective upon the date hereof, and subject only
     ------------------------
     to the conditions set forth herein, all provisions relating to the granting
     of registration rights and covenants related thereto made by the Company
     and Monsanto shall be contained in this Agreement. The registration rights
     and covenants provided herein set forth the sole and entire agreement
     between the Company and Monsanto on the subject matter of registration
     rights.
<PAGE>
 
                                   ARTICLE 2
                        Compliance with Securities Act
                        ------------------------------

2.1  Certain Definitions. As used in this Agreement, the following terms shall
     -------------------
     have the following respective meanings (all terms defined in this Article 2
     or in other provisions of this Agreement in the singular shall have the
     same meaning when used in the plural and vice versa)
                                              ----------

     "Affiliate" has the same meaning as in Rule 12b-2 promulgated under the 
      ---------
     Exchange Act.

     "Associate" has the same meaning as in Rule 12b-2 promulgated under the 
      ---------
     Exchange Act.

     "Board" or "Board of Directors" means the Board of Directors of the Company
      -----      ------------------
     except where the context otherwise requires.

     "Calgene" has the meaning set forth in the recitals herein.
      -------

     "Calgene Board" means the Board of Directors of Calgene.
      -------------

     "Calgene Director" means a member of the Calgene Board.
      ----------------

     "Commission" means the Securities and Exchange Commission or any other 
      ----------
     federal agency at the time administering the Securities Act.

     "Common Stock" means the Common Stock, $.001 par value, of the Company.
      ------------

     "Company" has the meaning set forth in the first paragraph hereof.
      -------

     "Company Credit Facility" means the Holding Company Credit Facility 
      -----------------------
     Agreement made as of even date herewith between the Company and 
     Monsanto.

     "Company Director" means an Independent Director who is nominated for such 
      ----------------
     position by the Company in accordance with Section 4.1 hereof.

     "Company Management Director" means the Chief Executive Officer (or, if 
      ---------------------------
     there is none at any time, a Director nominated by a majority of the
     Company Directors) and a second Director who shall be nominated by a
     majority of the Company Directors.

     "Company Securities" has the meaning set forth in Section 3.1 hereof.
      ------------------
<PAGE>
 
     "Control Securities" means securities of the Company, other than Restricted
      ------------------
     Securities, owned by a Holder at the time such Holder would be deemed to be
     an Affiliate of the Company.

     "Credit Facilities" means the Company Credit Facility and the Gargiulo
      -----------------
     Credit Facility.

     "Director" means a member of the Board of Directors of the Company.
      --------

     "Effective Date" means March 31, 1996.
      --------------

     "Employment Agreements" has the meaning set forth in Section 6.9        
      ---------------------
     hereof.

     "Equity Security" means (i) any Common Stock or other Voting Stock, (ii)
      ---------------
     any securities of the Company convertible into or exchangeable for Common
     Stock or other Voting Stock or (iii) any options, rights or warrants (or
     any similar securities) issued by the Company to acquire Common Stock or
     other Voting Stock.

     "Exchange Act" means the Securities Exchange Act of 1934, as amended.
      ------------

     "Financial Purchaser" means a Person (i) purchasing Company Securities from
      -------------------
     Monsanto for investment purposes or otherwise in the ordinary course of
     business and not for the purpose nor with the effect of changing or
     influencing the control of the Company and (ii) which Person is not already
     primarily in the same lines of business as the Company.

     "Gargiulo" means Gargiulo, Inc. formerly known as Tomato Investment 
      --------
     Associates, Inc.

     "Gargiulo Business" means the business transacted by Tomato Associates
      -----------------
     after the Effective Date, which business was transacted by Gargiulo prior
     to the Effective Date.

     "Gargiulo Credit Facility" means the Gargiulo Credit Facility Agreement
      ------------------------
     made as of even date herewith between the Company and Monsanto.

     "Holder" means Monsanto and, subject to Section 2.9 hereof and except for
      ------
     purposes of Article 3 hereof, any subsequent holder of outstanding
     Registrable Securities.

     "Indemnified Party" has the meaning set forth in Section 2.6(c) hereof.
      -----------------
<PAGE>
 
     "Indemnifying Party" has the meaning set forth in Section 2.6(c) hereof.
      ------------------

     "Independent Director" means a Director or Calgene Director (i) who is not
     --------------------
     and has never been an officer or employee of Calgene, the Company, any
     Affiliate or Associate of Calgene or the Company or of a Person that
     derived five percent (5%) or more of its revenues or earnings in its most
     recent fiscal year from transactions involving Calgene, the Company or any
     Affiliate or Associate of Calgene or the Company, (ii) who is not and has
     never been an officer or employee of Monsanto, any Affiliate or Associate
     of Monsanto or of a Person that derived more than five percent (5%) of its
     revenues or earnings in its most recent fiscal year from transactions
     involving Monsanto or any Affiliate or Associate of Monsanto, (iii) who is
     not and never has been an officer or employee of Gargiulo, any Affiliate or
     Associate of Gargiulo or of a Person that derived more than five percent
     (5%) of its revenues or earnings in its most recent fiscal year from
     transactions involving Gargiulo or any Affiliate or Associate of Gargiulo,
     (iv) who has no affiliation, compensation, consulting or contracting
     arrangement with Calgene, the Company, Monsanto, Gargiulo or their
     respective Affiliates or Associates or any other Person such that a
     reasonable person would regard such Director as likely to be unduly
     influenced by management of Calgene, the Company or Monsanto, respectively
     (provided, however, that no Person shall be regarded as being unduly
     influenced by the management of Monsanto merely because such Person serves
     or previously served as a director of Monsanto or any Affiliate or
     Associate of Monsanto), and (v) who has an outstanding reputation for
     personal integrity and distinguished achievement in areas relevant to the
     Company. Notwithstanding the foregoing, no member of the immediate family
     of any Person who does not qualify to be an Independent Director by reason
     of clause (i), (ii), (iii) or (iv) above shall be considered an Independent
     Director. For purposes of the preceding sentence, the term "immediate
     family" shall have the same meaning as set forth in Item 404(a) of
     Regulation S-K. Without limiting the foregoing, Roger H. Salquist shall
     qualify as an Independent Director so long as he continues to qualify under
     clauses (iv) and (v) of such definition. Roger H. Salquist shall not fail
     to qualify under clause (iv) above as a result of his Change in Control
     Employment Agreement dated July 19, 1995, as modified, or Consulting
     Agreement dated _____________, 1996 with the Company.

     "Monsanto" has the meaning set forth in the first paragraph hereof.
      --------

     "Monsanto Director" means a Director or Calgene Director, including any
      -----------------
     Monsanto Management Director, who is designated for such position by
     Monsanto in accordance with Section 4.1 hereof.
<PAGE>
 
     "Monsanto Management Director" means a Director or Calgene Director who is
      ----------------------------
     nominated for such position by Monsanto in accordance with Section 4.1
     hereof and who is or was an employee of Monsanto.

     "New Percentage Ownership" has the meaning set forth in Section 3.6(d) 
      ------------------------
     hereof.

     "Non-Financial Purchaser" means a Person, other than a Financial Purchaser,
      -----------------------
     purchasing Company Securities from Monsanto.

     "Operating Plan" has the meaning set forth in Section 4.4(a) (ix) hereof.
     --------------

     "Other Selling Stockholders" has the meaning set forth in Section 2.2(c)
      --------------------------
     hereof.

     "Percentage Interest" means the percentage of outstanding Voting Stock that
      -------------------
     is controlled directly or directly by Monsanto and its Affiliates.

     "Person" means a corporation, association, partnership, joint venture,
      ------
     limited liability company, individual, trust, unincorporated organization,
     a government agency or political subdivision thereof and any other entity.

     "Preliminary Prospectus means a preliminary prospectus as contemplated by
      ----------------------
     Rule 430 or 430A under the Securities Act included at any time in the
     Registration Statement.

     "Pre-Offering Percentage" has the meaning set forth in Section 3.1 hereof.
      -----------------------

     "Prospectus" means (i) the prospectus as first filed with the Commission
      ----------
     pursuant to Rule 424(b) under the Securities Act or, (ii) if no such filing
     is required, the form of final prospectus included in the Registration
     Statement at the effective date thereof or (iii) if a Term Sheet or
     Abbreviated Term Sheet (as such terms are defined in Rule 434(b) and
     434(c), respectively, under the Securities Act) is filed with the
     Commission pursuant to Rule 424(b) (7) under the Securities Act, the Term
     Sheet or Abbreviated Term Sheet and the last Preliminary Prospectus filed
     with the Commission prior to the time the Registration Statement became
     effective, taken together (including, in each case, the documents
     incorporated by reference therein pursuant to Item 12 of Form S-3 under the
     Securities Act), together with any supplement to any of the foregoing.

     "Registration Statement" means any registration statement of the Company
      ----------------------
     filed under the Securities Act which covers any of the Registrable
     Securities pursuant to the provisions of this Agreement, including the
     Prospectus relating thereto and all amendments and supplements to such
     registration statement, 
<PAGE>
 
     including post-effective amendments, all exhibits and all material
     incorporated or deemed to be incorporated by reference in such registration
     statement.

     "Registrable Securities" means shares of Common Stock issued or issuable to
      ----------------------
     Monsanto pursuant to the Transaction Agreements and the Stock Purchase
     Agreement whether owned by Monsanto or a permitted transferee of Monsanto
     and all such other securities of the Company acquired by Monsanto or any
     Affiliate of Monsanto in accordance herewith.

     "Register", "Registered" and "Registration", whether or not capitalized,
      --------    ----------       ------------
     mean and refer to a registration effected by preparing and filing a
     Registration Statement in compliance with the Securities Act and applicable
     rules and regulations thereunder, and the declaration or ordering of the
     effectiveness of such Registration Statement.

     "Registration Expenses" means all expenses incurred by the Company in
      ---------------------
     compliance with this Article 2, including, without limitation, all
     registration fees, qualification fees, filing fees, advertising and road
     show expenses (excluding advertising and road show expenses incurred by a
     Holder), printing expenses, escrow fees, fees and disbursements of counsel
     for the Company, blue sky fees and expenses, and the expense of any special
     audits incident to or required by any such registration (but excluding the
     compensation of regular employees of the Company, which shall be paid in
     any event by the Company).

     "Reorganization Agreement" has the meaning set forth in the recitals
      ------------------------
     herein.

     "Requesting Holder" means a Holder requesting any registration pursuant to 
      -----------------
     Section 2.2 hereof.

     "Restricted Securities" means the securities of the Company acquired by a
      ---------------------
     Holder from the Company or an Affiliate of the Company otherwise than
     pursuant to a public offering.

     "Section 16 Officers" has the meaning set forth in Section 4.3(b) (iii)
      -------------------
     hereof.

     "Securities Act" means the Securities Act of 1933, as amended.
      --------------

     "Selling Expenses" means all underwriting discounts and selling commissions
      ----------------
     applicable to the sale of Registrable Securities.

     "Strategic Plan" has the meaning set forth in Section 4.4(a) (ix) hereof.
      --------------
<PAGE>
 
     "Subsidiary" has the same meaning as in Rule l2b-2 promulgated under the 
      ----------
     Exchange Act.

     "Substantial Part" means more than ten percent (10%) of the total
      ----------------
     consolidated assets of the Company as shown on the Company's consolidated
     balance sheet as of the end of the most recent fiscal quarter ending prior
     to the time the determination is made.

     "Tomato Associates" has the meaning set forth in the recitals herein.
      -----------------

     "Transaction Agreements" has the meaning set forth in the Reorganization 
      ----------------------
     Agreement.

     "Trigger Event" means the earliest of (i) any time that Monsanto's
      -------------
     Percentage Interest is at least fifty-five percent (55%), (ii) the Company
     elects to convert borrowings made from Monsanto into Equity Securities and
     Monsanto's Percentage Interest is at least fifty percent (50%) after such
     conversion, or (iii) the closing of Monsanto's purchase of additional
     shares of Common Stock pursuant to the Stock Purchase Agreement.

     "Two Senior Gargiulo Officers" has the meaning set forth in Section 5.3
      ----------------------------
     hereof.

     "Unaffiliated Equity Holders" means holders of Equity Securities other than
      ---------------------------
     Monsanto or any of its Affiliates.

     "Voting Stock" means securities having the right to vote generally in any 
      ------------
     election of Directors of the Company (other than solely by reason of the 
     occurrence of an event).

2.2     Requested Registration.
        ----------------------

        (a) Request for Registration. Holders of Registrable Securities shall
            ------------------------
            have the right to request (with such requests in writing and stating
            the number of shares of Registrable Securities to be disposed of and
            the intended method of disposition of shares by such Holders) up to
            two (2) registrations on Form S-3 (and up to two (2) additional
            registrations on Form S-3 for each conversion of outstanding
            principal or interest into shares of Common Stock upon the
            occurrence of an "Event of Default" under the Company Credit
            Facility or the Gargiulo Credit Facility (as defined in each such
            Credit Facility, respectively)) at the Company's expense and an
            unlimited number of additional registrations on Form S-3 at the
            selling Holder's expense, provided that the requests for additional
            registrations are made by Holders of at least ten percent (10%) of
            the Registrable Securities, subject only to the following:
<PAGE>
 
      (i)   The Company shall not be required to effect a registration pursuant
            to this Section 2.2 prior to September 30, 1998, unless an Event of
            Default has occurred and is continuing under the Company Credit
            Facility or under the Gargiulo Credit Facility, in which event the
            Company shall be required to effect a registration pursuant to this
            Section 2.2 at any time upon the request of a Holder with respect to
            any shares of Common Stock issued to a Holder Upon conversion of
            outstanding principal or accrued interest under either the Company
            Credit Facility or the Gargiulo Credit Facility after the occurrence
            of an Event of Default under either of such agreements.

      (ii)  The Company shall not be required to effect a registration pursuant
            to this Section 2.2 within one hundred eighty (180) days after the
            effective date of the last such registration pursuant to this
            Section 2.2.

      (iii) The Company shall not be required to effect a Registration Statement
            in any particular jurisdiction in which the Company would be
            required to execute a general consent to service of process in
            effecting such registration, qualification or compliance, unless the
            Company is already subject to service in such jurisdiction and
            except as may be required by the Securities Act or applicable rules
            or regulations thereunder.

      (iv)  The Company shall not be required to effect a Registration Statement
            for a period of not more than ninety (90) days immediately following
            the delivery of a certificate signed by the President of the Company
            to the Requesting Holders stating that, in the good-faith judgment
            of the Board of Directors of the Company, it would be seriously
            detrimental to the Company and its shareholders for such
            Registration Statement to be filed on or before the date filing
            would otherwise be required hereunder; provided, however, that the
            Company may not utilize this right more than once in any twelve (12)
            month period and the Company may not exercise this right based on
            the fact that the Company has recently registered any of its
            securities for the account of a security holder or holders
            exercising their respective demand registration rights.

      If the Company cannot qualify for registration on Form S-3, then the
      Company shall effect any registration required or requested by the Holder
      on Form S-1, or such other appropriate form, in which event this Section
      2.2 shall apply in all respects as if the words "Form S-3" were
<PAGE>
 
      replaced by the words "Form S-1" or the appropriate designation for 
      such other form.

  (b) Notice of Inclusion. The Company shall give written notice to all Holders
      -------------------
      of Registrable Securities of the receipt of a request for registration
      pursuant to this Section 2.2 and shall provide a reasonable opportunity
      for other Holders to participate in the registration; provided, however,
      that, if the registration is for an underwritten offering, then the terms
      of Section 2.2(c) hereof shall apply to all participants in such offering.
      Subject to the foregoing, the Company shall use its best efforts to effect
      promptly the registration of all shares of Registrable Securities on Form
      S-3 to the extent requested by the Holder or Holders thereof for purposes
      of disposition.

  (c) Underwriting. If the Requesting Holders intend to distribute the
      ------------
      Registrable Securities covered by their request by means of an
      underwriting, then they shall so advise the Company as a part of their
      request made pursuant to this Section 2.2, and the Company shall include
      such information in the written notice referred to in Section 2.2(b)
      hereof. The right of any Holder to registration pursuant to this Section
      2.2 shall be conditioned upon such Holder's participation in such
      underwriting and the inclusion of such Holder's Registrable Securities in
      the underwriting to the extent requested and to the extent provided
      herein.

      The Company shall (together with all Holders proposing to distribute their
      securities through such underwriting) enter into an underwriting agreement
      in customary form with the representative of the underwriter or
      underwriters of recognized national standing, selected for such
      underwriting by a majority in interest of the Requesting Holders and
      reasonably acceptable to the Company. Notwithstanding any other provision
      of this Section 2.2, if the representative advises the Requesting Holders
      in writing that marketing factors require a limitation on the number of
      shares to be underwritten, then the Requesting Holders shall so advise all
      Holders, and the number of shares of Registrable Securities that may be
      included in the registration and underwriting shall be allocated first
      among all Holders thereof in proportion, as nearly as practicable, to the
      respective amounts of Registrable Securities held by such Holders at the
      time of filing the Registration Statement. No Registrable Securities
      excluded from the underwriting by reason of the underwriter's marketing
      limitation shall be included in such registration.

      If any Holder of Registrable Securities disapproves of the terms of the
      underwriting, then such person may elect to withdraw therefrom by 
<PAGE>
 
      written notice to the Company, the underwriter and the Requesting Holders.
      The Registrable Securities and/or other securities so withdrawn shall also
      be withdrawn from registration; provided, however, that, if, by the
      withdrawal of such Registrable Securities, a greater number of Registrable
      Securities held by other Holders may be included in such registration (up
      to the maximum of any limitation imposed by the underwriters), then the
      Company shall offer to all Holders who have included Registrable
      Securities in the registration the right to include additional Registrable
      Securities in the same proportion used to determine the underwriter
      limitation in this Section 2.2(c).

      If the underwriter has not limited the number of Registrable Securities to
      be underwritten, then the Company and its executive officers, and such
      other Persons as are determined by the Board of Directors, their
      successors, and their assigns ("Other Selling Stockholders"), may include
      securities for their own account in such registration if the underwriter
      so agrees and if the number of Registrable Securities held by the Holders
      that would otherwise have been included in such registration and
      underwriting will not thereby be limited for any reason, including but not
      limited to the price for which the Registrable Securities will be sold. To
      the extent that the underwriter wishes to limit the number of shares to be
      included in the registration on behalf of the Company and the Other
      Selling Stockholders, the shares of Common Stock to be registered held by
      the Other Selling Stockholders shall be excluded from such offering prior
      to excluding any shares held by the Company and those held by the Company
      shall be excluded prior to excluding any Registrable Securities held by
      the Holders.

2.3  Company Registration.
     --------------------
  
  (a) Notice and Inclusion. If, at any time after September 30, 1998, the
      --------------------
      Company shall determine to register any of its securities for its own
      account, other than a registration relating solely to employee benefit
      plans, or a registration relating solely to a Commission Rule 145
      transaction, the Company shall:

      (i)   promptly give to each Holder written notice thereof (which shall
            include a list of the jurisdictions in which the Company intends to
            attempt to qualify such securities under the applicable blue sky or
            other state securities laws); and

      (ii)  include in such registration (and any related qualification under
            blue sky laws or other compliance), and in any underwriting involved
            therein, all Registrable Securities specified in a written 
<PAGE>
 
            request or requests, within twenty (20) days after receipt of the
            written notice from the Company, by any Holder or Holders.

  (b) Underwriting. If the registration of which the Company gives notice is for
      ------------
      a registered public offering by the Company of its securities through an
      underwriting, then the Company shall so advise the Holders as a part of
      the written notice given pursuant to Section 2.3(a) (i) hereof. In such
      event, the right of any Holder to registration pursuant to this Section
      2.3 shall be conditioned upon such Holder's participation in such
      underwriting and the inclusion of such Holder's Registrable Securities in
      the underwriting to the extent provided herein. All Holders proposing to
      distribute their securities through such underwriting shall (together with
      the Company, and all the Other Selling Stockholders distributing their
      securities through such underwriting) enter into an underwriting agreement
      in customary form with the underwriter or underwriters selected for
      underwriting by the Company. Notwithstanding any other provision of this
      Section 2.3, if the underwriter determines that marketing factors require
      a limitation on the number of shares to be underwritten, then the
      underwriter may exclude from such registration and underwriting some or
      all of the Registrable Securities held by the Holders or the stock held by
      Other Selling Stockholders in accordance with this Section 2.3(b). The
      Company shall so advise all Holders and all Other Selling Stockholders
      distributing their securities through such underwriting, and (i) as to the
      first registration in which Holders are entitled to participate pursuant
      to this Section 2.3, the number of Registrable Securities and other
      securities that may be included in the registration and underwriting shall
      be allocated among all Holders thereof on the basis that shares held by
      all the Other Selling Stockholders who are not Holders shall first be
      excluded to the extent required and, if further exclusion is necessary,
      shares held by the selling Holders shall then be excluded; provided,
      however, that, as among the respective Other Selling Stockholders as a
      group on the one hand and the Holders as a group on the other hand
      suffering such exclusion, the exclusion shall be in proportion, as nearly
      as practicable, to the amount of securities entitled to inclusion in such
      registration held by each of the Other Selling Stockholders as a group and
      each of the Holders at the time of filing the Registration Statement; and
      (ii) as to all subsequent registrations, the number of shares of
      Registrable Securities and other securities that may be included in the
      registration and underwriting shall be allocated among all Other Selling
      Stockholders and the Holders in proportion, as nearly as practicable, to
      the respective amounts of securities entitled to inclusion in such
      registration held by all such Other Selling Stockholders and Holders at
      the time of filing the Registration Statement. For purposes of the
<PAGE>
 
        apportionment provisions in clause (i) above, for any selling Holder
        that is a partnership or corporation, the partners, retired partners,
        and shareholders of such Holder, the estate and family members of such
        partners and retired partners, and any trusts for the benefit of any of
        the foregoing persons shall be deemed to be a single "selling Holder,"
        and any pro rata reduction with respect to such selling Holder shall be
        based upon the aggregate number of shares carrying registration rights
        owned by all entities and individuals included in such "selling Holder,"
        as defined in this sentence. If any Other Selling Stockholder or Holder
        disapproves of the terms of any such underwriting, he may elect to
        withdraw therefrom by written notice to the Company and the underwriter.
        Any securities excluded or withdrawn from such underwriting shall be
        withdrawn from such registration.

2.4 Expenses of Registration. All Registration Expenses incurred in connection
    ------------------------
    with any registration qualification or compliance pursuant to this Article 2
    shall be borne by the Company; provided, however, that the Registration
    Expenses for the fifth and all subsequent registrations under Section 2.2(a)
    hereof requested by the Holders shall be borne by the requesting Holders pro
    rata on the basis of the number of their shares so registered. All Selling
    Expenses relating to the securities registered by Holders and, if
    applicable, Other Selling Stockholders, and fees and disbursements of
    counsel, shall be borne by the Holders or the Other Selling Stockholders, as
    the case may be, of such securities pro rata on the basis of the number of
    their shares so registered.

2.5 Registration procedures.
    -----------------------
    (a) Company shall use its best efforts to register or qualify the
        Registrable Securities covered by such Registration Statement under such
        other securities or blue sky laws of such United States jurisdictions as
        Holder shall reasonably request and do any and all acts and things which
        may be necessary or desirable to enable Holder to consummate the public
        sale or other disposition in such jurisdictions; provided, however, that
        Company shall not be required in connection therewith or as a condition
        thereto to qualify to do business or file a general consent to service
        of process in any such jurisdictions.

    (b) The Company represents and warrants that, on the date of its
        effectiveness, the Registration Statement will comply in all material
        respects with the applicable requirements of the Securities Act and the
        rules thereunder, including without limitation Rule 415; on the date of
        its effectiveness, the Registration Statement will not contain any
        untrue statement of a material fact or omit to state any material fact
        required to 
<PAGE>
 
        be stated therein or necessary in order to make the statements made
        therein not misleading; provided, however, that no representation is
        made by Company with respect to information relative to any Holder; and
        the Prospectus will not include any untrue statement of a material fact
        or omit to state a material fact necessary in order to make the
        statements therein, in light of the circumstances under which they were
        made, not misleading; provided, however, that no representation is made
        by Company with respect to information relative to any Holder.

    (c) If, at any time or times while the Registration Statement is effective,
        Company notifies Holder that a development has occurred or is pending
        which, based upon consultation with Company's legal counsel, Company
        reasonably believes may cause the then current Prospectus not to be in
        compliance with applicable securities laws, then Holder shall refrain
        from delivering the Prospectus and from making any offers or sales of
        Registrable Securities requiring the delivery of the Prospectus until
        such time as Company either notifies Holder that the Prospectus complies
        with such laws or delivers an amended Prospectus in replacement of the
        deficient Prospectus. Company shall use its reasonable best efforts to
        minimize the time during which Holder must so refrain, and no more than
        one (1) such period of refrain shall be imposed during any period of one
        hundred eighty (180) days.

    (d) At least two (2) business days prior to the initial filing of the
        Registration Statement or Prospectus and no fewer than two (2) business
        days prior to the filing of any amendment or supplement thereto
        (including any document that would be incorporated or deemed to be
        incorporated therein by reference), Company shall furnish Holder, its
        legal counsel and the managing underwriter, if any, copies of all such
        documents proposed to be filed, which documents (other than those
        incorporated or deemed to be incorporated by reference) shall be subject
        to review of Holder, its legal counsel and such underwriters, if any,
        and Company shall cause its officers and directors and the independent
        certified public accountants to Company to respond to such inquiries as
        shall be necessary, in the opinion of respective counsel to Company and
        any such underwriters, to conduct a reasonable investigation within the
        meaning of the Securities Act. Company shall not file any such
        Registration Statement or Prospectus or any amendments or supplements
        thereto to which Holder, its legal counsel, or the managing
        underwriters, if any, shall reasonably object on a timely basis (i.e.,
                                                                         ---
        within two (2) business days of receipt thereof).

    (e) Company shall promptly notify Holder when the Registration Statement is
        declared effective; notify Holder of any stop-order or similar
<PAGE>
 
        proceeding by the Commission or any state securities authority; and
        furnish such number of Prospectuses Prospectus supplements and other
        documents incident thereto as Holder from time to time may reasonably
        request.

    (f) In the event of any breach by Company of the provisions of Section 2.2,
        2.3, 2.4 or 2.5, the parties agree that Holder will suffer irreparable
        harm. Accordingly, the parties agree that the provisions of Sections
        2.2, 2.3, 2.4 and 2.5 are specifically enforceable by Holder and that
        Holder shall be entitled to temporary and permanent injunctive relief
        against Company and the other rights and remedies to which Holder may be
        entitled to at law, in equity or under this Agreement for any such
        breach.

2.6 Indemnification.
    ---------------

    (a) Indemnification by the Company. The Company shall indemnify each Holder
        ------------------------------
        with respect to which registration, qualification or compliance has been
        effected pursuant to this Article 2, each of its officers, directors,
        employees, agents and partners, each Person controlling such Holder
        within the meaning of Section 15 of the Securities Act, each
        underwriter, if any, and each Person who controls any underwriter within
        the meaning of Section 15 of the Securities Act, against all expenses,
        claims, losses, damages and liabilities (or actions in respect thereof),
        including any of the foregoing incurred in settlement of any litigation,
        commenced or threatened, arising out of or based on any untrue statement
        (or alleged untrue statement) of a material fact contained in any
        Prospectus, offering circular or other document (including any related
        Registration Statement, notification or the like) incident to any such
        registration qualification or compliance, or based on any omission (or
        alleged omission) to state therein a material fact required to be stated
        therein or necessary to make the statements therein not misleading, or
        any violation by the Company of the Securities Act or any rule or
        regulation thereunder applicable to the Company and relating to action
        or inaction required of the Company in connection with any such
        registration, qualification or compliance. The Company shall reimburse
        each such Holder, each of its officers, directors, employees, agents and
        partners, and each Person controlling such Holder, each such underwriter
        and each Person who controls any such underwriter for any legal and any
        other expenses reasonably incurred in connection with investigating,
        preparing or defending any such expense, claim, loss, damage, liability
        or action; provided, however, that the Company shall not be liable in
        any such case to the extent that any such claim, loss, damage,
        liability, action or expense arises out of or is based on any untrue
        statement or omission or alleged untrue statement or omission made in
        reliance upon 
<PAGE>
 
        and in conformity with written information furnished to the Company by
        an instrument duly executed by such Holder or underwriter and stated to
        be specifically for use therein.

    (b) Indemnification by the Holders. To the extent set forth in the second
        ------------------------------
        sentence of this Section 2.6(b), each Holder shall, if Registrable
        Securities or other securities held by such Holder are included in the
        securities as to which such registration qualification or compliance is
        being effected, indemnify the Company, each of its directors, officers,
        employees and agents, each underwriter, if any, of the Company's
        securities covered by such a Registration Statement, each Person who
        controls the Company or such underwriter within the meaning of Section
        15 of the Securities Act, each other such Holder, each of such other
        Holder's officers, directors, employees, agents and partners, and each
        Person controlling such Holder within the meaning of Section 15 of the
        Securities Act against all expenses, claims, losses, damages and
        liabilities (or actions in respect thereof), including any of the
        foregoing incurred in settlement of any litigation, commenced or
        threatened, arising out of or based on any untrue statement (or alleged
        untrue statement) of a material fact made by the Holder and contained in
        any such Registration Statement, Prospectus, offering circular or other
        document, or any amendment or supplement thereto or incident to any such
        registration qualification or compliance or based on any omission (or
        alleged omission) to state therein a material fact required to be made
        by the Holder and stated therein or necessary to make the statements
        therein not misleading or any violation by the Company of any rule or
        regulation promulgated under the Securities Act applicable to the
        Company in connection with such registration qualification or compliance
        as a result of any statement (or based on any omission to state or
        alleged omission) required to be made by such Holder. Each such Holder
        shall reimburse the Company, such other Holders, directors, officers,
        employees, agents, partners, Persons, underwriters and control persons
        for any legal or any other expenses reasonably incurred in connection
        with investigating, preparing or defending any such expense, claim,
        loss, damage, liability or action, in each case to the extent, but only
        to the extent, that such untrue statement (or alleged untrue statement)
        or omission (or alleged omission) is made in such Registration
        Statement, Prospectus, offering circular or other document or any
        amendment or supplement thereto in reliance upon and in conformity with
        written information furnished by the Holder to the Company by an
        instrument duly executed by such Holder and stated to be specifically
        for use therein; provided, however, that the obligations of such Holders
        hereunder shall be limited to an 
<PAGE>
 
        amount equal to the proceeds to each such Holder of Registrable
        Securities sold as contemplated herein in connection with the particular
        registration qualification or compliance involved.

    (c) Notice. Each party entitled to indemnification under this Section 2.6
        ------
        (the "Indemnified Party") shall give notice to the party required to
        provide indemnification (the "indemnifying Party") promptly after such
        Indemnified Party has actual knowledge of any claim as to which
        indemnity may be sought and shall permit the Indemnifying Party to
        assume the defense of any such claim or any litigation resulting
        therefrom; provided, however, that counsel for the Indemnifying Party,
        who shall conduct the defense of such claim or any litigation resulting
        therefrom, shall be approved by the Indemnified Party (whose approval
        shall not unreasonably be withheld), and that the Indemnified Party may
        participate in such defense at its own expense; and provided further
        that the failure of any Indemnified Party to give notice as provided
        herein shall not relieve the Indemnifying Party of its obligations under
        this Section 2.6 unless such failure resulted in detriment to the
        Indemnifying Party. No Indemnifying Party, in the defense of any such
        claim or litigation, shall, except with the consent of each Indemnified
        Party, consent to entry of any judgment or enter into any settlement
        which does not include as an unconditional term thereof the giving by
        the claimant or plaintiff to such Indemnified Party of a release from
        all liability in respect to such claim or litigation.

2.7 Information by Holder. Each Holder or Holders of Registrable Securities in
    ---------------------
    any registration shall furnish to the Company such information regarding
    such Holder or Holders and the distribution proposed by such Holder or
    Holders as the Company may reasonably request in writing but only to the
    extent as shall be required in connection with any registration
    qualification or compliance referred to in this Article 2.

2.8 Rule 144 Reporting. With a view to making available the benefits of certain
    ------------------
    rules and regulations of the Commission which may permit the sale of the
    Restricted Securities or Control Securities to the public without
    registration, the Company agrees to:

        (a) Use its best efforts to make and keep public information available
            as those terms are understood and defined in Rule 144 under the
            Securities Act;

        (b) Use its best efforts to file with the Commission in a timely manner
            all reports and other documents required of the Company under the
            Securities Act and the Exchange Act (at any time after it has become
<PAGE>
 
            subject to such reporting requirements);

        (c) For so long as a Holder owns any Restricted Securities or Control
            Securities, furnish to the Holder forthwith upon request (i) a
            written statement by the Company as to its compliance with the
            reporting requirements of Rule 144 and of the Securities Act and the
            Exchange Act, (ii) a copy of the most recent annual or quarterly
            report of the Company, and (iii) such other reports and documents so
            filed as such Holder may reasonably request in availing itself of
            any rule or regulation of the Commission allowing a Holder to sell
            any such securities without registration; and

        (d) When any Holder qualifies under Rule 144 for the unrestricted right
            of sale under Rule 144, the Company shall, upon written request of
            such Holder (such request to include sufficient detail as to
            establish how the Holder so qualifies under Rule 144), promptly
            remove any restrictive legend that may have been placed on any
            Restricted or Control Securities and issue Common Stock of the
            Company free of such restrictive or other legends.

2.9  Transfer of Registration Rights. The rights to cause the Company to
     -------------------------------
     register the Registrable Securities granted to each Holder by the Company
     under Sections 2.2 and 2.3 hereof may be transferred or assigned to a
     transferee or assignee in connection with the transfer or assignment of not
     less than one million (1,000,000) shares of the Registrable Securities;
     provided, however, that the Company shall be entitled to notice of any such
     transfer of registration rights within thirty (30) days of the date such
     transfer is effected.

2.10 Limitations on Subsequent Registration Rights. No owner or prospective
     ---------------------------------------------
     owner of securities of the Company shall have any registration rights other
     than as set forth in this Agreement. The Company shall not, without the
     prior written consent of the Holders (which consent shall not be
     unreasonably withheld) of not less than sixty-six and two- thirds percent
     (66-2/3%) of the Registrable Securities then held by Holders, enter into
     any agreement with any owner or prospective owner of any securities of the
     Company that would allow such owner or prospective owner to include such
     securities in any registration filed under this Article 2 if such inclusion
     would adversely affect the rights of any Holder.

2.11 Termination of Registration Rights. The registration rights granted
     ----------------------------------
     pursuant to this Article 2 shall terminate as to each Holder at such time
     as (a) all Registrable Securities can be sold within a given three (3)
     month period without compliance with the registration requirements of the
     Securities Act pursuant to Rule 144 supported by a written opinion of legal
     counsel for the 
<PAGE>
 
     Company, which opinion shall be reasonably satisfactory in form and
     substance to legal counsel for such Holders, and (b) all accrued interest
     and principal under the Company Credit Facility and the Gargiulo Credit
     Facility has been repaid in full or converted into Common Stock of the
     Company (and such Common Stock can be sold as provided in (a) above).

2.12 "Market Stand-off" Agreement. Each Holder hereby agrees that, to the extent
      ----------------
     requested by the Company and an underwriter of a sale of Common Stock (or
     other securities) of the Company for the account of the Company and not for
     the account of a security holder or holders exercising their respective
     demand registration rights, it shall not sell or otherwise transfer or
     dispose of (other than to transferees who agree to be similarly bound) any
     Registrable Securities during the ninety (90) day period following the
     effective date of a registration statement of the Company filed under the
     Securities Act; provided, however, that all officers and directors of the
     Company, all Other Selling Stockholders and all other Persons with
     registration rights (whether or not pursuant to this Agreement) shall enter
     into similar agreements. To enforce the foregoing covenant, the Company may
     impose stop-transfer instructions with respect to the Registrable
     Securities of each Holder (and the shares or securities of every other
     Person subject to the foregoing restriction) until the end of such ninety
     (90) day period.


                                   ARTICLE 3
                 Anti-Dilution Rights and Limitations on Owner
                 ---------------------------------------------

3.1  Anti-Dilution Rights. If, at any time after the Effective Date, Company
     --------------------
     agrees to sell shares of its Common Stock or other Voting Stock ("Company
     Securities") in a private or public offering (other than Company Securities
     issued pursuant to the Company's stock option plans), Holder shall have the
     right, but not the obligation, to acquire all or any portion of the Company
     Securities sufficient for Holder to maintain, after the offering, the same
     percentage of ownership of issued and outstanding Company Securities that
     Holder possessed immediately prior to the offering (the "Proffering
     Percentage"). With respect to the issuance of Company Securities pursuant
     to the Company's stock option plans, Holder shall have a right to maintain
     its percentage ownership of issued and outstanding Company Securities by
     making open market purchases as provided in Section 3.5 hereof.

3.2  Private Offering. With respect to a private offering, other than pursuant
     ----------------
     to a Company stock option plan, Company shall, within five (5) business
     days after the execution of any agreement entered into in connection with
     such private offering, notify Holder in writing of the proposed offering
     and provide Holder with copies of all related documentation, including, for
     example, any letter of 
<PAGE>
 
     intent and the final contract. Holder shall have twenty (20) business days
     from the date of receipt of Company's notice in which to advise Company
     whether Holder elects to exercise its rights under Section 3.1 hereof. If
     Holder does not respond, or if Holder indicates that it will not exercise
     its rights, Holder shall be considered irrevocably to have waived its
     rights under Section 3.1 hereof with respect to such specific private
     offering. If Holder timely advises Company that Holder will exercise its
     rights under Section 3.1 hereof, Holder shall have the right to acquire all
     or any portion of the necessary amount of the Company Securities to
     maintain Holder's Proffering Percentage at the price or value of the
     consideration specified in the private offering agreement entered into
     between Company and the purchaser. Closing shall be in accordance with the
     terms of the private offering agreement, and Holder shall make such
     investment representations to Company and shall provide Company with such
     other documentation at closing as is reasonably required by Company to
     comply with applicable securities laws.

3.3  Public Offering. With respect to a public offering, Company shall notify
     ---------------
     Holder no later than five (5) business days after Company has entered into
     a letter of intent with its underwriters, and shall provide Holder with a
     copy of the letter of intent. Holder shall have twenty (20) business days
     from the date of receipt of Company's notice in which to advise Company
     whether Holder elects to exercise its rights under Section 3.1 hereof. If
     Holder does not respond or if Holder indicates that it will not exercise
     its rights, Holder shall be considered irrevocably to have waived its
     rights under Section 3.1 hereof with respect to the public offering. If
     Holder timely advises Company that Holder desires to retain its rights
     under Section 3.1 hereof, then, when Company files a Registration Statement
     containing a Preliminary Prospectus with the Commission, Company shall
     provide Holder with copies of the Preliminary Prospectus and all subsequent
     amendments. Holder shall have twenty (20) business days from its receipt of
     the Preliminary Prospectus in which to exercise its rights under Section
     3.1 hereof by making an offer to acquire all or any portion of the
     necessary amount of Company Securities to maintain Holder's pre-Offering
     Percentage based on the price, less all Selling Expenses, and the other
     terms contained in the final Prospectus. No such offer to buy shall be
     accepted prior to the time that the Registration Statement becomes
     effective. The Registration Statement shall indicate that Holder has anti-
     dilution rights to purchase Company Securities on the terms offered to the
     public.

3.4  Limitations. Notwithstanding the preceding provisions of this Article 3,
     -----------
     Company shall not be required to issue any fractional shares as a result of
     Holder's exercise of its rights under Section 3.1 hereof. Company shall not
     be required to transfer any Company Securities to Holder under this Article
     3 if to do so would result in the violation of any applicable law, rule or
     regulation.
<PAGE>
 
3.5  Open Market Purchases to Maintain Ownership Percentage. Notwithstanding any
     ------------------------------------------------------
     other provision hereof, at any time after the Effective Date, Holder may
     make such open market purchases of Company Securities as are necessary to
     maintain Holder's percentage of ownership of issued and outstanding Company
     Securities at fifty-three percent (53%) (or such higher percentage as may
     be permitted under Section 3.6 hereof) or to increase its percentage of
     ownership of issued and outstanding Company Securities to fifty-three
     percent (53%) (or such higher percentage as may be permitted under Section
     3.6 hereof). With respect to the issuance of Company Securities pursuant to
     a Company stock option plan or any warrant, conversion right or other
     option, Company shall notify Holder no later than ten (10) calendar days
     after the end of each calendar quarter and within ten (10) calendar days of
     the record date for a shareholder meeting and for dividend payments for
     Company Securities of the number of shares and issuance price of Company
     Securities issued pursuant to Company's stock option plans or any warrant,
     conversion right or other option subsequent to the last notice given
     pursuant to this Section 3.5 so as to enable Holder to make open market
     purchases of Company Securities as permitted under this Section 3.5.

3.6  Limitations on Holder's Ownership. Except for purchases of Company
     ---------------------------------
     Securities made in accordance with this Article 3, during the term of this
     Agreement, Holder shall not directly or indirectly acquire any Company
     Securities except as follows:

     (a) On and after March 31, 1996 until September 30, 1998, Holder shall not
         increase or further increase its ownership of issued and outstanding
         Company Securities above fifty-three percent (53%), except through one
         (1) or more of the following:

         (i)   Conversion of principal and/or interest under the Company Credit
               Facility or the Gargiulo Credit Facility into shares of Common
               Stock;

         (ii)  Issuance of Company Securities in an asset sale by Holder to
               Company; and

         (iii) A tender offer by Holder to increase its ownership to seventy
               percent (70%) or more of the issued and outstanding Company
               Securities at a price approved by the disinterested Directors of
               Company and based upon a fairness opinion delivered to the Board
               of Directors of the Company by an investment banking firm;
               provided, however, that, if Holder makes a tender offer to
               increase its ownership to more than eighty percent (80%) of the
               issued and outstanding Company Securities, such tender offer 
<PAGE>
 
               must be for one hundred percent (100%) of the publicly traded
               Company Securities.

      (b) After September 30, 1998, Holder may increase its ownership of Company
          Securities through open market purchases or otherwise.

      (c) If, at any time after the Effective Date, Holder shall elect to
          increase its percentage of ownership of issued and outstanding Company
          Securities above fifty-three percent (53%) as provided in paragraph
          (a) above (such increased percentage hereafter being the "New
          Percentage Ownership"), then thereafter Holder may make such open
          market purchases of Company Securities as are necessary to maintain
          such New Percentage Ownership or to increase its percentage of
          ownership of issued and outstanding Company Securities to such New
          Percentage Ownership.

      (d) Holder shall not be required to dispose of any Company Securities if
          Holder's percentage ownership of Company Securities is increased as a
          result of any recapitalization by Company or any other action taken by
          Company.

3.7   Limitations on Holder's Resale of Company Securities. Holder shall not
      ----------------------------------------------------
      directly or indirectly sell any Company Securities (other than to an
      Affiliate of Holder) except as follows:

      (a) On and after the first anniversary of the Effective Date until the
          earlier of September 30, 1998, or the third anniversary of the
          Effective Date, Holder may sell Company Securities (i) as part of a
          joint venture, merger or sale of all or substantially all of its
          current Crop Protection business unit, as such business may be
          subsequently renamed or reorganized, or (ii) pursuant to a tender
          offer by a third party to the shareholders of Company.

      (b) After the earlier of September 30, 1998, or the third anniversary of
          the Effective Date, in addition to the rights to sell Company
          Securities set forth in paragraph (a) above, Holder may sell Company
          Securities (i) in a registered public offering pursuant to the
          registration rights granted to Holder under this Agreement, (ii)
          through sales pursuant to Rule 144 under the Securities Act, (iii)
          through sales of not more than ten percent (10%) of the total issued
          and outstanding Company Securities to a Non-Financial Purchaser, or
          (iv) through sales to a Financial Purchaser.

      (c) After the earlier of September 30, 1999, or the fourth anniversary of
          the Effective Date, in addition to the rights to sell Company
          Securities as set forth in paragraphs (a) and (b) above, Holder may
          sell Company 
<PAGE>
 
          Securities through a private sale of thirty-five percent (35%) or more
          of the total issued and outstanding Company Securities to a Non-
          Financial Purchaser under circumstances where such third party assumes
          the applicable and proportionate rights and obligations of Holder
          under this Agreement and the other Transaction Agreements.

      (d) Notwithstanding the foregoing, at any time after the Effective Date,
          Holder may sell Company Securities issued to Holder upon conversion by
          Holder of principal or accrued interest under either of the Credit
          Facilities after the occurrence of an Event of Default under either of
          such Credit Facilities.


                                   ARTICLE 4
                   Company and Calgene Corporate Governance

4.1   Composition of the Board of Directors and Calgene Board. The number of
      -------------------------------------------------------
      Directors comprising both the Board of Directors and the Calgene Board and
      the manner of nominating the members thereof shall be as follows:

      (a) The number of Directors comprising the Board of Directors shall
          initially be fixed at nine (9) Directors. The number of such Directors
          may be increased only in accordance with Section 4.4(a) (xii) hereof.
          The parties agree that the manner of nominating, and the governance
          provisions relating to, the Board of Directors and the Calgene Board
          shall be identical, and that the provisions of this Section 4.1 set
          forth below and of Sections 4.3(c) and 4.3(d) hereof shall be deemed
          to apply equally to the Calgene Board and Calgene Directors.
          Accordingly, when applied to the Calgene Board, the term "Director"
          shall be deemed to mean "Calgene Director", the term "Company",
          whether used alone or as a modifier, shall be deemed to mean
          "Calgene", and the term "Board of Directors" shall be deemed to mean
          "Calgene Board".

      (b) Until changed in accordance with this Agreement, the Board of
          Directors shall be comprised of nine (9) Directors, and the Company
          shall nominate for election as Directors: (i) one (1) Company
          Management Director, (ii) three (3) Company Directors, and (iii) five
          (5) Directors designated by Monsanto, at least one (1) of which shall
          be an Independent Director.

      (c) [This section intentionally left blank]

      (d) At any time that Monsanto's Percentage Interest is at least seventy
          percent (70%), (i) the Corporation shall nominate: (i) six (6)
          Directors 
<PAGE>
 
          designated by Monsanto, which shall consist of the one (1) Company
          Management Director and five (5) other Monsanto Directors (including
          at least one (1) Independent Director) and (ii) three (3) Independent
          Directors. At such time as Monsanto's Percentage Interest is at least
          ninety-nine percent (99%), the Corporation shall nominate nine (9)
          Directors designated by Monsanto.

      (e) Notwithstanding anything in the foregoing paragraphs (b), (c) and (d)
          to the contrary, (i) at any time Monsanto's Percentage Interest is
          less than forty percent (40%) but at least twenty percent (20%), The
          Company shall nominate three (3) Directors designated by Monsanto,
          (ii) at any time Monsanto's Percentage Interest is less than twenty
          percent (20%) but at least ten percent (10%), the Company shall
          nominate two (2) Directors designated by Monsanto and (iii) at any
          time Monsanto's Percentage Interest is less than ten percent (10%) but
          at least five percent (5%), the Company shall nominate one (1)
          Director designated by Monsanto. If, at any time, Monsanto's
          Percentage Interest is less than five percent (5%), the Company shall
          not be obligated to nominate any Director designated by Monsanto. At
          any such time, all other Directors, other than the Company Management
          Directors, shall be nominated by the Company.

      (f) The Independent Directors to be nominated by the Company from time to
          time shall be nominated by action of a majority of Company Directors
          then in office. The Company Directors shall consult with the other
          Independent Directors as to the nomination of any Company Director,
          and in the event a majority of the Company Directors are unable to
          agree upon any Company Director nominee, then the majority of all the
          Independent Directors shall nominate such nominee. In the event that
          no Company Directors are in office at the time of any nomination of a
          Company Director, such Company Directors shall be nominated by a
          majority of the Independent Directors then in office; provided,
          however, that the holders of a majority of the outstanding Voting
          Stock held by Unaffiliated Equity Holders shall be entitled to
          nominate and elect Company Directors in lieu of any individuals so
          nominated to be such Company Directors by a majority of the
          Independent Directors.

      (g) The Company and Monsanto, respectively, shall have the right to
          nominate any replacement for a Director nominated in accordance with
          this Section 4.1 by the Company or Monsanto, respectively, upon the
          death, resignation, retirement, disqualification or removal from
          office for cause of such Director. Such replacement for any
          Independent Director shall also be an Independent Director unless, in
          the case of a 
<PAGE>
 
          replacement of a Monsanto Director, the Monsanto Directors include
          more than the required number of Independent Directors. The Board of
          Directors shall elect each person so nominated by Monsanto or the
          Company pursuant to this paragraph (g). In addition, the Board of
          Directors shall nominate the Company's Chief Executive Officer to
          replace such officer's predecessor in office as a Company Management
          Director.

      (h) In the event that the number of Monsanto Directors on the Board of
          Directors differs from the number that Monsanto has the right (and
          wishes) to designate for nomination pursuant to this Section 4.1, (i)
          if the number of Monsanto Directors exceeds such number, Monsanto
          shall promptly take all appropriate action to cause to resign that
          number of Monsanto Directors as is required to make the remaining
          number of such Monsanto Directors conform to this Section 4.1 or (ii)
          if the number of Monsanto Directors otherwise is less than such
          number, the Company shall promptly take all necessary action to create
          sufficient vacancies on the Board of Directors to permit Monsanto to
          designate the full number of Monsanto Directors which it is entitled
          (and wishes) to nominate pursuant to this Section 4.1 (such action to
          include seeking the resignation or removal of Directors or, at the
          request of Monsanto, calling a special meeting of the stockholders of
          the Company for the purpose of removing Directors to create such
          vacancies to the extent permitted by applicable law). Upon the
          creation of any vacancy pursuant to the preceding sentence, Monsanto
          shall nominate the person to fill such vacancy in accordance with this
          Section 4.1 and the Board of Directors shall elect each person so
          nominated. Notwithstanding the foregoing, at each annual meeting of
          the stockholders of the Company, the Company shall nominate such
          number of Directors as Monsanto is otherwise entitled to designate
          under this Section 4.1.

      (i) Notwithstanding anything herein to the contrary, no individual who is
          an officer, director, employee, agent, partner or principal
          stockholder of any competitor of the Company or any of its Affiliates
          (other than Monsanto and its Affiliates) or any competitor of Monsanto
          or any of its Affiliates (other than the Company) shall serve as a
          Director without the unanimous consent of the Board of Directors.

      (j) In the event that Monsanto desires to remove any Monsanto Director
          with or without cause and Monsanto is unable to procure the
          resignation of such Monsanto Director, then, upon the request of
          Monsanto, the Board of Directors shall promptly call a special meeting
          of stockholders of the Corporation for purposes of removing such
          Monsanto Director. In the event that the Company desires to remove 
<PAGE>
 
          any Company Director with or without cause and the Company is unable
          to procure the resignation of such Company Director, then, upon the
          request of a majority of all of the Independent Directors then in
          office, the Board of Directors shall promptly call a special meeting
          of stockholders of the Company for purposes of removing such Company
          Director. In the event that the Chief Executive Officer's employment
          with the Company is terminated for any reason, then upon the request
          of either Monsanto or a majority of all of the Independent Directors
          then in office, the Board of Directors shall promptly call a special
          meeting of stockholders of the Corporation for the purpose of removing
          such person as a Company Management Director.

4.2   Solicitation and Voting of Shares.
      ---------------------------------
 
      (a) The Company shall use its best efforts to solicit from the
          stockholders of the Company eligible to vote for the election of
          Directors proxies in favor of the Company Management Directors and the
          nominees designated in accordance with Section 4.1 hereof or the
          removal of any Director pursuant to Section 4.1(h) or 4.1(j) hereof.

      (b) In any election of Directors or any meeting of the stockholders of the
          Company called expressly for the removal of Directors, so long as the
          Board of Directors includes (and will include after any such removal)
          the number of Monsanto Directors contemplated by Section 4.1 hereof
          and so long as such meeting is properly called and Monsanto is
          properly notified in accordance with the Company's by-laws and
          certificate of incorporation, Monsanto and its Affiliates shall attend
          such meeting for purposes of establishing a quorum and shall vote all
          their shares of Voting Stock (i) in favor of any nominee or Director
          designated in accordance with Section 4.1 hereof, (ii) in favor of
          removal of any Director as contemplated by Section 4.1(h) or 4.1(j)
          hereof, and (iii) otherwise against the removal of any Director
          designated in accordance with Section 4.1 hereof (other than in cases
          of removal of a Director for cause); provided, however, that, if
          Monsanto and its Affiliates elect to cumulate their votes in
          accordance with the Company's by-laws and certificate of
          incorporation, then, in any vote electing Monsanto Directors, Monsanto
          and its Affiliates may cast all of their votes in favor of one (1) or
          more of the Monsanto Directors designated by Monsanto and in any vote
          with respect to the removal of a Monsanto Director, Monsanto and its
          Affiliates may cast all or any portion of their votes either in favor
          or against the removal of any Monsanto Director unless a Monsanto
          Director is otherwise required to be removed in accordance with
          Section 4.1(h) hereof. In any other matter submitted to a vote of the
          stockholders of the Company, 
   
<PAGE>
 
          Monsanto and its Affiliates may vote any or all of their shares in
          their sole discretion.

      (c) Monsanto agrees that it will, and will cause any of its Subsidiaries
          (other than the Company and its Subsidiaries) to, take all action as a
          stockholder of the Company or as is otherwise reasonably within its
          control, as necessary to effect the provisions of this Agreement,
          including, without limitation, voting all shares of Voting Stock in
          favor of all persons nominated in accordance with Section 4.1 hereof;
          provided, however, that, if Monsanto cannot so take actions to give
          effect to all of the provisions of this Agreement, it may first take
          actions to ensure that it receives all of its benefits hereunder and
          then, to the extent possible, to give effect to the provisions in
          favor of the Company.

4.3   Committees.

      (a) The Board of Directors shall establish, empower and maintain the
          committees of the Board of Directors contemplated by this Section 4.3.

      (b) The following committees shall be established, empowered and
          maintained by the Board of Directors at all times during the term of
          this Agreement:

          (i)   an Audit Committee, consisting of at least three (3) of the
                Company's Independent Directors, which committee shall be
                authorized and empowered to cause an audit to be performed of
                the Company and each of its Subsidiaries;

          (ii)  [This section intentionally left blank]

          (iv)  such other committees as the Board of Directors deems necessary
                or desirable; provided, however, that such committees are
                established in compliance with Section 4.4(a)(vi) hereof.

          For purpose of clause (ii) above, "executive officers" shall have the
          same meaning as in Rule 3b-7 promulgated under the Exchange Act.

      (c) Except as otherwise provided in Section 4.3(b) hereof or as agreed by
          a majority of the Monsanto Management Directors, the number of
          Monsanto Directors on each committee of the Board of Directors shall
          be the same proportion (but not less than one (1)) of the total
          membership of such committee as the number of Monsanto Directors, as
          the case may be, is of the entire Board of Directors. Except as
          otherwise provided in Section 4.3(b) hereof, the Monsanto Directors on
          each 
<PAGE>
 
          committee of the Board of Directors shall be determined by a
          majority of the Monsanto Management Directors.

      (d) No action by any committee of the Board of Directors shall be valid
          unless taken by unanimous written consent as provided in the Company's
          by-laws or taken at a meeting for which adequate notice has been duly
          given or waived by the members of such committee. Such notice shall
          include a description of the general nature of the business to be
          transacted at the meeting, and no other business may be transacted at
          such meeting unless all members of the committee are present and
          consent to the consideration of such other business. Any committee
          member unable to participate in person at any meeting shall be given
          the opportunity to participate by telephone. The Board of Directors or
          the remaining committee members shall designate an Independent
          Director or Company Management Director to replace any absent or
          disqualified Independent Director member or Company Management
          Director member, respectively, of any committee and a majority of the
          Monsanto Management Directors shall designate a Monsanto Director to
          replace any absent or disqualified Monsanto Director member of any
          committee. Each of the committees established by the Board of
          Directors pursuant to this Section 4.3 shall establish such other
          rules and procedures for its operation and governance (consistent with
          the terms of this Agreement) as it shall see fit and may seek such
          consultation and advice as to matters within its purview as it shall
          require.

4.4   Approval Required for Certain Actions.
      -------------------------------------

      (a) On and after the Effective Date and until the earlier of a Trigger
          Event or such date on which Monsanto's Percentage Interest is less
          than twenty-five (25%), a majority of the Board, including at least
          one (1) Company Director and one (1) Monsanto Management Director,
          shall be required to approve any of the following:

          (i)   the entry by the Company or any of its Affiliates into any
                merger or consolidation or the acquisition by the Company or any
                of its Affiliates of any business or assets that would
                constitute a Substantial Part of the Company (determined on a
                consolidated basis) whether such acquisition be by merger or
                consolidation or the purchase of stock or assets or otherwise;

          (ii)  the sale, pledge, grant of security interest in, transfer,
                retirement or other disposal of (A) a Substantial Part of the
                Company (determined on a consolidated basis), except pursuant to
                a security interest granted in connection with borrowings
                permitted 
<PAGE>
 
                 under subsection (iv) below or (B) the pledge or granting of a
                 security interest in any intangible property set forth in
                 Exhibit B attached to the disclosure letter from Monsanto to
                 Calgene dated June 27, 1995;

          (iii)  any dividend by or return of capital by the Company or Gargiulo
                 (other than such distributions by Gargiulo to the Company as
                 are necessary for the Company to timely perform its obligations
                 under Sections 1.02 and 5.02(c) of the Gargiulo Credit
                 Facility);

          (iv)   any incurrence or assumption, in the aggregate, by the Company,
                 any of its Affiliates or any combination thereof, of any
                 indebtedness for borrowed money at any time outstanding
                 exceeding in the aggregate (determined on a consolidated basis)
                 the greater of (i) Fifteen Million Dollars ($15,000,000),
                 increasing by Five Million Dollars ($5,000,000) on each July 1
                 commencing July 1, 1996, plus amounts secured by inventory
                 and/or receivables for seasonal working capital lines and
                 indebtedness incurred to acquire property, plant or equipment
                 and secured by the acquired asset, minus amounts outstanding
                 under the Company Credit Facility, or (ii) the amounts set
                 forth in the Company's Operating Plan (hereinafter defined),
                 provided that loans under the Gargiulo Credit Facility shall
                 not be counted in this limitation;

          (v)    the repurchase or redemption of any Equity Securities of the
                 Company, other than from employees upon termination of
                 employment or service;

          (vi)   the establishment of any new committees of the Board (or the
                 Calgene Board) or new or revised delegation(s) of Board (or the
                 Calgene Board) authority to any Board (or Calgene Board)
                 committee or changes or revisions to general delegations of
                 authority to officers or other Persons for categories of
                 expenditures;

          (vii)  the adoption of or amendment to any benefit or incentive plans
                 of the Company or any of its Affiliates which would increase
                 the annual cost thereof by more than fifteen percent (15%) from
                 the prior fiscal year or any adoption of, or amendment to, any
                 stock option plan;

          (viii) the election, appointment or removal of the Chief Executive
                 Officer, Chief Operating Officer or Chief Financial Officer of
                 the
<PAGE>
 
                 Company and Calgene and their successors and the establishment
                 of their annual or long term compensation level and benefits
                 and basis for awards (other than agreements in effect on the
                 Effective Date); provided, however, that Monsanto shall have
                 the right to select the Chief Technical Officer of the Company
                 and a controller reporting to the Chief Financial Officer of
                 the Company;

          (ix)   approval of the annual operating plan ("Operating Plan") and
                 long-term strategic plan ("Strategic Plan") of the Company and
                 its Affiliates, as well as the annual operating plan and long-
                 term strategic plan for the Gargiulo Business, to be submitted
                 to the Board annually for approval, and any material changes
                 thereto;

          (x)    any transaction between the Company (and its Affiliates), on
                 the one hand, and its (their) directors, officers or employees,
                 on the other hand, which is not in the normal course of
                 business;

          (xi)   any modification of the Transaction Agreements;

          (xii)  any amendment of the by-laws or certificate of incorporation of
                 the Company, Calgene or Tomato Associates by the respective
                 Boards of Directors thereof;

          (xiii) the issuance of any warrants for the purchase of Equity
                 Securities or the issuance of additional Equity Securities
                 (other than warrants for the purchase of Equity Securities) in
                 excess of four million (4,000,000) shares of Common Stock in
                 any two (2) year period to a third party, other than pursuant
                 to plans referred to in subsection (vii) above;

          (xiv)  the sale or licensing by the Company or any of its Affiliates
                 of (A) any intangible property set forth in Exhibit B attached
                 to the disclosure letter from Monsanto to Calgene dated June
                 27, 1995 or (B) any other intangible property for consideration
                 (other than royalties contingent on future sales) exceeding
                 Five Million Dollars ($5,000,000) in the aggregate (determined
                 on a consolidated basis) per transaction or per series of
                 related transactions;

          (xv)   new fixed capital investments, capital leases or noncancellable
                 operating leases by the Company and its Affiliates having
                 annual payments in the aggregate (determined on a consolidated
                 basis) exceeding the aggregate amount set forth in the
                 Operating Plan;
<PAGE>
 
          (xvi)   [This section intentionally left blank]

          (xvii)  any press release which mentions or directly or indirectly
                  refers to Monsanto, except as required by law and where Board
                  approval cannot be obtained in a timely manner;

          (xviii) the initiation, settlement or termination of any suit or
                  proceeding concerning intellectual property, any other matter
                  which could have an adverse public affairs effect upon
                  Monsanto or the filing of any insolvency or bankruptcy
                  proceeding by or on behalf of the Company or any of its
                  Affiliates; or

          (xix)   the removal or election of the directors, subject to Section
                  5.1 hereof, of Tomato Associates.


      (b) After a Trigger Event and until the earlier of (i) the third
          anniversary of the Effective Date or (ii) Monsanto's Percentage
          Interest is at least seventy percent (70%), a majority of the Board,
          including at least two (2) Company Directors, shall be required to
          approve any of the following:

          (i)   the matters set forth in subsections (i), (ii), (vi), (viii),
                (ix) and (xi) of paragraph (a) above; or

          (ii)  any transaction between the Company (and its Affiliates) and
                Monsanto or any Affiliate of Monsanto.

      (c) From and after the occurrence of both (i) a Trigger Event and (ii) the
          third anniversary of the Effective Date, and until Monsanto's
          Percentage Interest is at least ninety-nine percent (99%), neither
          Monsanto nor any of its Affiliates shall enter into any transaction
          with the Company or any of its Affiliates without the approval of at
          least two (2) Company Directors.

4.5   Enforcement of this Agreement. The Independent Directors, acting by
      -----------------------------
      unanimous consent, shall have full and complete authority on behalf of the
      Company to enforce the terms of this Agreement.

4.6   Certificate of Incorporation and By-laws. The Company and Monsanto shall
      ----------------------------------------
      take or cause to be taken all lawful action necessary to ensure at all
      times that the Company's and Calgene's Certificate of Incorporation and 
      By-laws are not at any time inconsistent with the provisions of this
      Agreement. Not later than the Effective Date, the Board of Directors shall
      amend the Company's By-laws and the Calgene Board shall amend Calgene's 
      By-laws to reflect the provisions of this Agreement.
<PAGE>
 
4.7   Advisors. The Independent Directors shall be entitled to retain, at the
      --------
      cost and expense of the Company, the services of an investment banking
      firm of national reputation of their choice and one (1) law firm of their
      choice to advise them in their capacity as Independent Directors with
      respect to any matter on which the Independent Directors are required or
      permitted to act hereunder.

4.8   Injunctive Relief. In the event of a breach of the provisions of this
      -----------------
      Article 4, a party hereto entitled to rights under this Article 4 will
      suffer irreparable harm and the total amount of monetary damages will be
      impossible to calculate and will therefore be an inadequate remedy.
      Accordingly, in such event, such party shall be entitled to temporary and
      permanent injunctive relief against the Company and any other breaching
      party and to any other rights and remedies to which such party may be
      entitled to at law or in equity.


                                   ARTICLE 5
                            Governance of Gargiulo
                            ----------------------

      [This Article intentionally left blank.]



                                   ARTICLE 6
                                 Miscellaneous
                                 -------------

6.1   Governing Law. This Agreement shall be governed in all respects by the
      -------------
      laws of the State of Delaware (exclusive of such state's choice of laws
      rules).

6.2   Successors and Assigns. Except as otherwise provided herein, the
      ----------------------
      provisions hereof shall inure to the benefit of, and be binding upon, the
      successors, assigns, heirs, executors, and administrators of the parties
      hereto.

6.3   Entire Agreement; Amendment. This Agreement and the other documents
      ---------------------------
      delivered pursuant hereto constitute the complete, exclusive and final
      understanding and agreement between the parties with regard to the
      subjects hereof and thereof. Except as specifically set forth herein, any
      term of Section 2 or 3 hereof may be waived only with the prior written
      consent of the Company and the Holders of at least sixty-six and two-
      thirds percent (66-2/3%) of the outstanding shares of the Registrable
      Securities. Any amendment or waiver effected in accordance with this
      Section 6.3 shall be binding upon each Holder of the Registrable
      Securities (including securities into which such Registrable Securities
      have been converted) outstanding at the 
<PAGE>
 
      time, each future Holder of all such securities, and the Company. Any
      provision of this Agreement may be amended or waived if, and only if, such
      amendment or waiver is in writing and signed, in the case of an amendment,
      by the Company and Monsanto, or in the case of a waiver, by the party
      against whom the waiver is to be effective; provided that no such
      amendment or waiver shall be effective without the approval of all of the
      Independent Directors.

6.4   Notices. Any notice required or permitted to be given under this Agreement
      -------
      shall be in writing, and shall be deemed sufficiently given when delivered
      in person or transmitted by telegram or telecopier (confirmed by mail),
      addressed as follows:

      If to Monsanto:                   Monsanto Company
                                        800 North Lindbergh Boulevard
                                        St. Louis, Missouri  63167
                                        Attention:  Assistant Secretary
                                        Telecopy Number:  314-694-2574

      If to any other Holder, at such address and telecopy number as such Holder
      shall have furnished the Company in writing.

      If to Company:                    Calgene, Inc.
                                        1920 Fifth Street
                                        Davis, California  95616
                                        Attention:  Chairman and Chief Executive
                                                    Officer
                                        Telecopy Number:        916-753-1510

      or to such other address as may be specified from time to time in a notice
      given by such party. The parties agree to acknowledge in writing the
      receipt of any such notice delivered in person.

6.5   Delays or Omissions. No delay or omission to exercise any right, power or
      -------------------
      remedy accruing to any Holder of any Registrable Securities, upon any
      breach or default of the Company under this Agreement, shall impair any
      such right, power or remedy of such Holder nor shall it be construed to be
      a waiver of any such breach or default, or an acquiescence therein, or of
      or in any similar breach or default thereafter occurring. Any waiver,
      permit, consent or approval of any kind or character on the part of any
      party or any waiver on the part of any party of any provisions or
      conditions of this Agreement must be made in writing and shall be
      effective only to the extent specifically set forth in such writing. All
      remedies, either under this Agreement, at law, in 
<PAGE>
 
      equity or otherwise afforded to any party, shall be cumulative and not
      alternative.

6.6   Counterparts. This Agreement may be executed in any number of
      ------------
      counterparts, each of which shall be an original, but all of which
      together shall constitute one instrument.

6.7   Severability. In the event that any provision of this Agreement becomes or
      ------------
      is declared by a court of competent jurisdiction to be illegal,
      unenforceable or void, this Agreement shall continue in full force and
      effect without said provision; provided, however, that no such
      severability shall be effective if it materially changes the economic
      benefit of this Agreement to any party.

6.8   Stock Legends. Subject to Section 2.8(d) hereof, certificates representing
      -------------
      Restricted Securities (other than Restricted Securities issued to Monsanto
      in connection with the conversion of principal and/or accrued interest
      under the Company Credit Facility or the Gargiulo Credit Facility upon the
      occurrence of an Event of Default under either such Credit Facility)
      issued to Monsanto pursuant to the Transaction Agreements shall bear the
      following legend:

           "The securities represented by this certificate are subject to
           certain resale restrictions and entitled to the benefits set forth in
           a Stockholders Agreement dated March 31, 1996, between Calgene II,
           Inc., a Delaware corporation, and Monsanto Company, a Delaware
           corporation (the "Agreement") . A copy of the Agreement and all
           amendments thereto is on file in the office of the Secretary of the
           Company."

6.9   [This section intentionally left blank.]

6.10  Audits Consultants and Inspections. Monsanto (using Monsanto's internal
      and/or external auditors or any other Person appointed by Monsanto to whom
      the Company does not reasonably object) shall have the right (i) to audit
      the books and records, other financial information and business practices
      and operations of the Company and its Affiliates, and (ii) to discuss the
      business practices and operations, affairs, finances and accounts of the
      Company and its Affiliates with the officers of the Company and its
      Affiliates and the independent public accountants who review or audit the
      Company's financial statements, all at such reasonable times and as often
      as may reasonably be requested. The Company shall also permit inspection
      of its (and its Affiliates') properties, books and records by Monsanto
      (using the Persons identified above) during normal business hours or at
      other reasonable times. The scope of all such audits, discussions and
      inspections shall be determined by Monsanto in its sole discretion. Any
      authorized representative of Monsanto 
<PAGE>
 
      who or which is not employed by Monsanto (i) shall be required to execute
      a confidentiality agreement in a form approved by the Board of Directors
      (which approval shall not be unreasonably withheld or delayed) and (ii)
      may not be employed by or affiliated with a competitor of the Company, as
      reasonably determined by the Board of Directors; provided, however, that
      an independent certified public accounting firm shall not be deemed to be
      employed by or affiliated with a competitor of the Company even if such
      firm provides services to a competitor of the Company.

6.11  No Third Party Beneficiaries. Nothing contained in this Agreement, express
      ----------------------------
      or implied, is intended to or shall confer upon anyone other than the
      parties hereto (and their successors and assigns, including, without
      limitation, subsequent Holders and purchasers under Section 3.7(c)) any
      right, benefit or remedy of any nature whatsoever under or by reason of
      this Agreement.

6.12  Sections and Articles. All sections and articles referred to herein are
      ---------------------
      sections and articles of this Agreement.

6.13  Headings. Headings as to the contents of particular articles and sections
      --------
      are for convenience only and are in no way to be construed as part of this
      Agreement or as a limitation of the scope of the particular articles or
      sections to which they refer.

IN WITNESS WHEREOF, the parties have caused this Agreement to be duly executed
and delivered as of the day and year first above written.

                                                CALGENE II, INC



                                                By:    
                                                   ---------------------------


                                                MONSANTO COMPANY



                                                By: 
                                                   ---------------------------

<PAGE>
 
                                                                       EXHIBIT B



             [Amendment to Restated Certificate of Incorporation]






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