MORGAN STANLEY UNIVERSAL FUNDS INC
497, 1998-10-06
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<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                        EMERGING MARKETS DEBT PORTFOLIO
 
                                    OF THE
 
                     MORGAN STANLEY UNIVERSAL, FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Emerging Markets Debt Portfolio. Paul Ghaffari no
longer serves as Portfolio Manager of the Emerging Markets Debt Portfolio.
Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna now share primary
responsibility for managing the assets of the Emerging Markets Debt Portfolio.
Accordingly, the section "PORTFOLIO MANAGER." on page 19 is hereby deleted and
replaced with the following:
 
    PORTFOLIO MANAGER. The following persons have primary responsibility for
  the Portfolio.
 
    Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna. Thomas L.
  Bennett, a Managing Director of Morgan Stanley, joined MAS in 1984. He
  assumed responsibility for the MAS Funds Fixed Income Portfolio in 1984,
  the MAS Funds Domestic Fixed Income Portfolio in 1987, the MAS Funds High
  Yield Portfolio in 1985, the MAS Funds Fixed Income Portfolio II in 1990,
  the MAS Funds Special Purpose Fixed Income and Balanced Portfolios in 1992
  and the MAS Funds Multi-Asset-Class Portfolio in 1994. Mr. Bennett is
  Chairman of the Board of Trustees of MAS Funds, a member of the Executive
  Committee of MAS and a Director of MAS Fund Distributors, Inc. Mr Bennett
  holds a B.S. in Chemistry and an M.B.A. from University of Cincinnati.
  Stephen F. Esser, a Managing Director of Morgan Stanley, joined MAS in
  1988. He assumed responsibility for the MAS Funds High Yield Portfolio in
  1989. Mr. Esser holds a B.S. from University of Delaware. Abigail L.
  McKenna joined MSAM in 1996 and is a Vice President of MSAM and Morgan
  Stanley. She focuses primarily on the trading and management of the
  emerging markets debt portfolios. Prior to joining MSAM, she was a Senior
  Portfolio Manager at MIMCO from 1995 to 1996 and a Limited Partner at Weiss
  Peck & Greer from 1991 to 1995, where she was responsible for the trading
  and management of Corporate Bond Portfolios. She holds a B.A. in
  International Relations from Georgetown University and is a Chartered
  Financial Analyst. Messrs. Bennett and Esser and Ms. McKenna have shared
  primary responsibility for managing the Portfolio's assets since October
  1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                        EMERGING MARKETS DEBT PORTFOLIO
                            GLOBAL EQUITY PORTFOLIO
                        INTERNATIONAL MAGNUM PORTFOLIO
                       EMERGING MARKETS EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Emerging Markets Debt Portfolio. Paul Ghaffari no
longer serves as Portfolio Manager of the Emerging Markets Debt Portfolio.
Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna now share primary
responsibility for managing the assets of the Emerging Markets Debt Portfolio.
Accordingly, the first paragraph under "PORTFOLIO MANAGERS." on page 23 is
hereby deleted and replaced with the following:
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Thomas L. Bennett, a Managing Director of Morgan
  Stanley, joined MAS in 1984. He assumed responsibility for the MAS Funds
  Fixed Income Portfolio in 1984, the MAS Funds Domestic Fixed Income
  Portfolio in 1987, the MAS Funds High Yield Portfolio in 1985, the MAS
  Funds Fixed Income Portfolio II in 1990, the MAS Funds Special Purpose
  Fixed Income and Balanced Portfolios in 1992 and the MAS Funds Multi-Asset-
  Class Portfolio in 1994. Mr. Bennett is Chairman of the Board of Trustees
  of MAS Funds, a member of the Executive Committee of MAS and a Director of
  MAS Fund Distributors, Inc. Mr Bennett holds a B.S. in Chemistry and an
  M.B.A. from University of Cincinnati. Stephen F. Esser, a Managing Director
  of Morgan Stanley, joined MAS in 1988. He assumed responsibility for the
  MAS Funds High Yield Portfolio in 1989. Mr. Esser holds a B.S. from
  University of Delaware. Abigail L. McKenna joined MSAM in 1996 and is a
  Vice President of MSAM and Morgan Stanley. She focuses primarily on the
  trading and management of the emerging markets debt portfolios. Prior to
  joining MSAM, she was a Senior Portfolio Manager at MIMCO from 1995 to 1996
  and a Limited Partner at Weiss Peck & Greer from 1991 to 1995, where she
  was responsible for the trading and management of Corporate Bond
  Portfolios. She holds a B.A. in International Relations from Georgetown
  University and is a Chartered Financial Analyst. Messrs. Bennett and Esser
  and Ms. McKenna have shared primary responsibility for managing the
  Portfolio's assets since October 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
                AS PREVIOUSLY SUPPLEMENTED ON SEPTEMBER 1, 1998
 
                             HIGH YIELD PORTFOLIO
                          U.S. REAL ESTATE PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            ASIAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Emerging Markets Debt Portfolio. Paul Ghaffari no
longer serves as Portfolio Manager of the Emerging Markets Debt Portfolio.
Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna now share primary
responsibility for managing the assets of the Emerging Markets Debt Portfolio.
Accordingly, the third paragraph under "PORTFOLIO MANAGERS." on page 24 is
hereby deleted and replaced with the following:
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Information about Thomas L. Bennett and Stephen F.
  Esser is included under High Yield Portfolio above. Abigail L. McKenna
  joined MSAM in 1996 and is a Vice President of MSAM and Morgan Stanley. She
  focuses primarily on the trading and management of the emerging markets
  debt portfolios. Prior to joining MSAM, she was a Senior Portfolio Manager
  at MIMCO from 1995 to 1996 and a Limited Partner at Weiss Peck & Greer from
  1991 to 1995, where she was responsible for the trading and management of
  Corporate Bond Portfolios. She holds a B.A. in International Relations from
  Georgetown University and is a Chartered Financial Analyst. Messrs. Bennett
  and Esser and Ms. McKenna have shared primary responsibility for managing
  the Portfolio's assets since October 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                            FIXED INCOME PORTFOLIO
                                VALUE PORTFOLIO
                          U.S. REAL ESTATE PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Emerging Markets Debt Portfolio. Paul Ghaffari no
longer serves as Portfolio Manager of the Emerging Markets Debt Portfolio.
Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna now share primary
responsibility for managing the assets of the Emerging Markets Debt Portfolio.
Accordingly, the fourth paragraph under "PORTFOLIO MANAGERS." on page 23 is
hereby deleted and replaced with the following:
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Information about Thomas L. Bennett is included under
  Fixed Income Portfolio above. Stephen F. Esser, a Managing Director of
  Morgan Stanley, joined MAS in 1988. He assumed responsibility for the MAS
  Funds High Yield Portfolio in 1989. Mr. Esser holds a B.S. from University
  of Delaware. Abigail L. McKenna joined MSAM in 1996 and is a Vice President
  of MSAM and Morgan Stanley. She focuses primarily on the trading and
  management of the emerging markets debt portfolios. Prior to joining MSAM,
  she was a Senior Portfolio Manager at MIMCO from 1995 to 1996 and a Limited
  Partner at Weiss Peck & Greer from 1991 to 1995, where she was responsible
  for the trading and management of Corporate Bond Portfolios. She holds a
  B.A. in International Relations from Georgetown University and is a
  Chartered Financial Analyst. Messrs. Bennett and Esser and Ms. McKenna have
  shared primary responsibility for managing the Portfolio's assets since
  October 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                             HIGH YIELD PORTFOLIO
                            MID CAP VALUE PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Emerging Markets Debt Portfolio. Paul Ghaffari no
longer serves as Portfolio Manager of the Emerging Markets Debt Portfolio.
Thomas L. Bennett, Stephen F. Esser and Abigail L. McKenna now share primary
responsibility for managing the assets of the Emerging Markets Debt Portfolio.
Accordingly, the third paragraph under "PORTFOLIO MANAGERS." on page 23 is
hereby deleted and replaced with the following:
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Information about Thomas L. Bennett and Stephen F.
  Esser is included under High Yield Portfolio above. Abigail L. McKenna
  joined MSAM in 1996 and is a Vice President of MSAM and Morgan Stanley. She
  focuses primarily on the trading and management of the emerging markets
  debt portfolios. Prior to joining MSAM, she was a Senior Portfolio Manager
  at MIMCO from 1995 to 1996 and a Limited Partner at Weiss Peck & Greer from
  1991 to 1995, where she was responsible for the trading and management of
  Corporate Bond Portfolios. She holds a B.A. in International Relations from
  Georgetown University and is a Chartered Financial Analyst. Messrs. Bennett
  and Esser and Ms. McKenna have shared primary responsibility for managing
  the Portfolio's assets since October 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                             HIGH YIELD PORTFOLIO
                            EQUITY GROWTH PORTFOLIO
                                VALUE PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            GLOBAL EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth and Emerging Markets Debt
Portfolios. Kurt A. Feuerman no longer serves as a Portfolio Manager of the
Equity Growth Portfolio. Philip W. Friedman and William S. Auslander now share
primary responsibility for managing the assets of the Equity Growth Portfolio
with Margaret K. Johnson. In addition, Paul Ghaffari no longer serves as
Portfolio Manager of the Emerging Markets Debt Portfolio. Thomas L. Bennet,
Stephen F. Esser and Abigail L. McKenna now share primary responsibility for
managing the assets of the Emerging Market Debt Portfolio. Accordingly, the
second and fourth paragraphs under "PORTFOLIO MANAGERS." on page 25 is hereby
deleted and replaced with the following:
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Philip W. Friedman is a Managing Director of Morgan
  Stanley and MSAM and is a member of MSAM's investment management team. In
  addition to portfolio management, his equity research responsibilities
  include business equipment and services, capital goods, consumer durables,
  multi-industry and transportation. Prior to joining MSAM in 1997, he was
  the North American Director of Equity Research at Morgan Stanley. From 1990
  to 1995, he was a member of Morgan Stanley's Equity Research team. Mr.
  Friedman graduated from Rutgers University with a B.A. (Phi Beta Kappa and
  Summa Cum Laude) in Economics. He also holds an M.B.A. from the J. L.
  Kellogg School of Management at Northwestern University. Margaret K.
  Johnson is a Principal of MSAM and Morgan Stanley and a Portfolio Manager
  in the Institutional Equity Group. She joined MSAM in 1984. She holds a
  B.A. degree from Yale College and is a Chartered Financial Analyst. William
  S. Auslander is a Vice President of MSAM and Morgan Stanley. He joined MSAM
  in 1995 as an equity analyst in the Institutional Equity Group. Prior to
  joining MSAM, he worked at Icahn & Co. for nine years as an equity analyst.
  He graduated from the University of Wisconsin at Madison with a B.A. in
  Economics and received an M.B.A. from Columbia University. Ms. Johnson has
  shared primary responsibility for managing the Portfolio's assets since its
  inception. Messrs. Friedman and Auslander have shared primary
  responsibility for managing the Portfolio's assets since September 1998.
<PAGE>
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Information about Thomas L. Bennett and Stephen F.
  Esser is included under High Yield Portfolio above. Abigail L. McKenna
  joined MSAM in 1996 and is a Vice President of MSAM and Morgan Stanley. She
  focuses primarily on the trading and management of the emerging markets
  debt portfolios. Prior to joining MSAM, she was a Senior Portfolio Manager
  at MIMCO from 1995 to 1996 and a Limited Partner at Weiss Peck & Greer from
  1991 to 1995, where she was responsible for the trading and management of
  Corporate Bond Portfolios. She holds a B.A. in International Relations from
  Georgetown University and is a Chartered Financial Analyst. Messrs. Bennett
  and Esser and Ms. McKenna have shared primary responsibility for managing
  the Portfolio's assets since October 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                            MONEY MARKET PORTFOLIO
                            FIXED INCOME PORTFOLIO
                             HIGH YIELD PORTFOLIO
                             CORE EQUITY PORTFOLIO
                            EQUITY GROWTH PORTFOLIO
                                VALUE PORTFOLIO
                           MID CAP GROWTH PORTFOLIO
                            MID CAP VALUE PORTFOLIO
                          U.S. REAL ESTATE PORTFOLIO
                     INTERNATIONAL FIXED INCOME PORTFOLIO
                        EMERGING MARKETS DEBT PORTFOLIO
                            GLOBAL EQUITY PORTFOLIO
                        INTERNATIONAL MAGNUM PORTFOLIO
                       EMERGING MARKETS EQUITY PORTFOLIO
                            ASIAN EQUITY PORTFOLIO
                           LATIN AMERICAN PORTFOLIO
                              BALANCED PORTFOLIO
                          MULTI-ASSET-CLASS PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Core Equity, Equity Growth, Emerging Markets Debt
and Asian Equity Portfolios. Kurt A. Feuerman no longer serves as a Portfolio
Manager of the Core Equity and Equity Growth Portfolios. Philip W. Friedman
and William S. Auslander now share primary responsibility for managing the
assets of the Equity Growth Portfolio with Margaret K. Johnson. Mr. Friedman
has also been added as a Portfolio Manager of the Core Equity Portfolio. In
addition, Paul Ghaffari no longer serves as Portfolio Manager of the Emerging
Markets Debt Portfolio. Thomas L. Bennett, Stephen F. Esser and Abigail L.
McKenna now share primary responsibility for managing the assets of the
Emerging Markets Debt Portfolio. Furthermore, Timothy Jensen and Ashutosh
Sinha now share responsibility for managing the assets of the Asian Equity
Portfolio with Vinod Sethi. Accordingly, the fourth, fifth, eleventh and
fifteenth paragraphs under "PORTFOLIO MANAGERS." are hereby deleted and
replaced with the following:
 
    CORE EQUITY PORTFOLIO--Arden C. Armstrong, Philip W. Friedman, James J.
  Jolinger, Nicholas J. Kovich, Robert J. Marcin, Gary G. Schlarbaum, and
  Brian Kramp. Arden C. Armstrong, a Managing Director of Morgan Stanley,
  joined MAS in 1986. She assumed responsibility for the MAS Funds Mid Cap
  Growth Portfolio in 1990, the MAS Funds Growth Portfolio in 1993 and the
  MAS Funds Equity Portfolio in 1994. Ms. Armstrong received a B.A. (Magna
  Cum Laude) in Economics from Brown University, an M.B.A. from the Wharton
  School at University of Pennsylvania and is a Chartered Financial Analyst.
  Philip W. Friedman is a Managing Director of Morgan Stanley and MSAM and is
  a member of MSAM's investment management team. In addition to portfolio
  management, his equity research responsibilities include business equipment
  and services, capital goods, consumer durables, multi-industry and
  transportation. Prior to joining MSAM in 1997, he was the North American
  Director of Equity Research at
<PAGE>
 
  Morgan Stanley. From 1990 to 1995, he was a member of Morgan Stanley's
  Equity Research team. Mr. Friedman graduated from Rutgers University with a
  B.A. (Phi Beta Kappa and Summa Cum Laude) in Economics. He also holds an
  M.B.A. from the J. L. Kellogg School of Management at Northwestern
  University. James J. Jolinger, a Vice President of Morgan Stanley, joined
  MAS in 1994. He served as Equity Analyst for Oppenheimer Capital from 1987-
  1994. Nicholas J. Kovich, a Managing Director of Morgan Stanley, joined MAS
  in 1988. He assumed responsibility for the MAS Funds Equity Portfolio in
  1994. Mr. Kovich received a B.S. in Chemical Engineering and an M.B.A. from
  University of Kansas. Robert J. Marcin, a Managing Director of Morgan
  Stanley, joined MAS in 1988. He assumed responsibility for the MAS Funds
  Value Portfolio in 1990 and the MAS Funds Equity Portfolio in 1994. Mr.
  Marcin holds a B.A. (Cum Laude) from Dartmouth College and is a Chartered
  Financial Analyst. Gary G. Schlarbaum, a Managing Director of Morgan
  Stanley, joined MAS in 1987. He assumed responsibility for the MAS Funds
  Equity and Small Cap Value Portfolios in 1987, the MAS Funds Balanced
  Portfolio in 1992 and the MAS Funds Multi-Asset-Class and Mid Cap Value
  Portfolios in 1994. Mr. Schlarbaum holds a B.A. from Coe College and a
  Ph.D. from University of Pennsylvania. Brian Kramp, a Vice President of
  Morgan Stanley, joined MAS in 1997. He served as Analyst/Portfolio Manager
  for Meridian Asset Management and its successor, CoreStates Investment
  Advisors from 1985-1997. Ms. Armstrong and Messrs. Friedman, Jolinger,
  Kovich, Marcin, Schlarbaum and Kramp have shared primary responsibility for
  managing the Portfolio's assets since its inception.
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Information about Philip W. Friedman is included
  under Core Equity Portfolio above. Margaret K. Johnson is a Principal of
  MSAM and Morgan Stanley and a Portfolio Manager in the Institutional Equity
  Group. She joined MSAM in 1984. She holds a B.A. degree from Yale College
  and is a Chartered Financial Analyst. William S. Auslander is a Vice
  President of MSAM and Morgan Stanley. He joined MSAM in 1995 as an equity
  analyst in the Institutional Equity Group. Prior to joining MSAM, he worked
  at Icahn & Co. for nine years as an equity analyst. He graduated from the
  University of Wisconsin at Madison with a B.A. in Economics and received an
  M.B.A. from Columbia University. Ms. Johnson has shared primary
  responsibility for managing the Portfolio's assets since its inception.
  Messrs. Friedman and Auslander have shared primary responsibility for
  managing the Portfolio's assets since September 1998.
 
    EMERGING MARKETS DEBT PORTFOLIO--Thomas L. Bennett, Stephen F. Esser and
  Abigail L. McKenna. Information about Thomas L. Bennett is included under
  Fixed Income Portfolio above. Information about Stephen F. Esser is
  included under High Yield Portfolio above. Abigail L. McKenna joined MSAM
  in 1996 and is a Vice President of MSAM and Morgan Stanley & Co.
  Incorporated. She focuses primarily on the trading and management of the
  emerging markets debt portfolios. Prior to joining MSAM, she was a Senior
  Portfolio Manager at MIMCO from 1995 to 1996 and a Limited Partner at Weiss
  Peck & Greer from 1991 to 1995, where she was responsible for the trading
  and management of Corporate Bond Portfolios. She holds a B.A. in
  International Relations from Georgetown University and is a Chartered
  Financial Analyst. Messrs. Bennett and Esser and Ms. McKenna have shared
  primary responsibility for managing the Portfolio's assets since October
  1998.
<PAGE>
 
    ASIAN EQUITY PORTFOLIO--Vinod Sethi, Timothy Jensen and Ashutosh Sinha.
  Vinod Sethi joined MSAM in 1989 and since then, has been actively involved
  in MSAM's emerging market group. Mr. Sethi is a Managing Director of Morgan
  Stanley and MSAM and is MSAM's Chief Investment Officer for the Asian
  region. He received his undergraduate degree in Chemical Engineering from
  I.I.T. (Bombay) and his M.B.A. from New York University School of Business.
  Timothy Jensen joined MSAM in 1998. He is a Principal of Morgan Stanley and
  MSAM and a member of MSAM's emerging markets group focusing primarily on
  the East Asian markets. Prior to joining MSAM, he was a Partner at Ardsley
  Partners, where he managed a portion of the emerging markets assets. Prior
  to that, he was a Vice President at Bankers Trust Company where he was
  responsible for a Latin American equity portfolio. He graduated from
  Harvard College with a B.A. in History and received an M.B.A. in Finance
  from UCLA. Ashutosh Sinha joined MSAM in 1995. He is a Vice President of
  Morgan Stanley and MSAM and a member of MSAM's emerging markets group
  focusing primarily on the East Asian and Middle Eastern markets. Prior to
  joining MSAM, he spent two years at SBI Funds Management Ltd., where he was
  an analyst for the India Magnum Fund. Previous to that, he worked for three
  years as a consultant for Citicorp Overseas Software Ltd. He graduated from
  I.I.T. (Kanpur) with a degree in Electrical Engineering and received an
  M.B.A. from the Indian Institute of Management, Calcutta. Mr. Sethi has had
  primary responsibility for managing the Asian Equity Portfolio since April
  1998 and Mr. Jensen and Mr. Sinha have shared primary responsibility for
  managing the Asian Equity Portfolio since August 1, 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                            FIXED INCOME PORTFOLIO
                             HIGH YIELD PORTFOLIO
                            EQUITY GROWTH PORTFOLIO
                                VALUE PORTFOLIO
                            GLOBAL EQUITY PORTFOLIO
                       EMERGING MARKETS EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth Portfolio. Kurt A. Feuerman no
longer serves as a Portfolio Manager of the Equity Growth Portfolio. Philip W.
Friedman and William S. Auslander now share primary responsibility for
managing the assets of the Equity Growth Portfolio with Margaret K. Johnson.
Accordingly, the third paragraph under "PORTFOLIO MANAGERS." on page 25 is
hereby deleted and replaced with the following:
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Philip W. Friedman is a Managing Director of Morgan
  Stanley and MSAM and is a member of MSAM's investment management team. In
  addition to portfolio management, his equity research responsibilities
  include business equipment and services, capital goods, consumer durables,
  multi-industry and transportation. Prior to joining MSAM in 1997, he was
  the North American Director of Equity Research at Morgan Stanley. From 1990
  to 1995, he was a member of Morgan Stanley's Equity Research team. Mr.
  Friedman graduated from Rutgers University with a B.A. (Phi Beta Kappa and
  Summa Cum Laude) in Economics. He also holds an M.B.A. from the J. L.
  Kellogg School of Management at Northwestern University. Margaret K.
  Johnson is a Principal of MSAM and Morgan Stanley and a Portfolio Manager
  in the Institutional Equity Group. She joined MSAM in 1984. She holds a
  B.A. degree from Yale College and is a Chartered Financial Analyst. William
  S. Auslander is a Vice President of MSAM and Morgan Stanley. He joined MSAM
  in 1995 as an equity analyst in the Institutional Equity Group. Prior to
  joining MSAM, he worked at Icahn & Co. for nine years as an equity analyst.
  He graduated from the University of Wisconsin at Madison with a B.A. in
  Economics and received an M.B.A. from Columbia University. Ms. Johnson has
  shared primary responsibility for managing the Portfolio's assets since its
  inception. Messrs. Friedman and Auslander have shared primary
  responsibility for managing the Portfolio's assets since September 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                             HIGH YIELD PORTFOLIO
                            EQUITY GROWTH PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth Portfolio. Kurt A. Feuerman no
longer serves as a Portfolio Manager of the Equity Growth Portfolio. Philip W.
Friedman and William S. Auslander now share primary responsibility for
managing the assets of the Equity Growth Portfolio with Margaret K. Johnson.
Accordingly, the second paragraph under "PORTFOLIO MANAGERS." on page 21 is
hereby deleted and replaced with the following:
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Philip W. Friedman is a Managing Director of Morgan
  Stanley and MSAM and is a member of MSAM's investment management team. In
  addition to portfolio management, his equity research responsibilities
  include business equipment and services, capital goods, consumer durables,
  multi-industry and transportation. Prior to joining MSAM in 1997, he was
  the North American Director of Equity Research at Morgan Stanley. From 1990
  to 1995, he was a member of Morgan Stanley's Equity Research team. Mr.
  Friedman graduated from Rutgers University with a B.A. (Phi Beta Kappa and
  Summa Cum Laude) in Economics. He also holds an M.B.A. from the J. L.
  Kellogg School of Management at Northwestern University. Margaret K.
  Johnson is a Principal of MSAM and Morgan Stanley and a Portfolio Manager
  in the Institutional Equity Group. She joined MSAM in 1984. She holds a
  B.A. degree from Yale College and is a Chartered Financial Analyst. William
  S. Auslander is a Vice President of MSAM and Morgan Stanley. He joined MSAM
  in 1995 as an equity analyst in the Institutional Equity Group. Prior to
  joining MSAM, he worked at Icahn & Co. for nine years as an equity analyst.
  He graduated from the University of Wisconsin at Madison with a B.A. in
  Economics and received an M.B.A. from Columbia University. Ms. Johnson has
  shared primary responsibility for managing the Portfolio's assets since its
  inception. Messrs. Friedman and Auslander have shared primary
  responsibility for managing the Portfolio's assets since September 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                       TO PROSPECTUS DATED MAY 1, 1998,
                AS PREVIOUSLY SUPPLEMENTED ON SEPTEMBER 1, 1998
 
                            FIXED INCOME PORTFOLIO
                             HIGH YIELD PORTFOLIO
                            EQUITY GROWTH PORTFOLIO
                                VALUE PORTFOLIO
                            MID CAP VALUE PORTFOLIO
                            GLOBAL EQUITY PORTFOLIO
                        INTERNATIONAL MAGNUM PORTFOLIO
                       EMERGING MARKETS EQUITY PORTFOLIO
                            ASIAN EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth Portfolio. Kurt A. Feuerman no
longer serves as a Portfolio Manager of the Equity Growth Portfolio. Philip W.
Friedman and William S. Auslander now share primary responsibility for
managing the assets of the Equity Growth Portfolio with Margaret K. Johnson.
Accordingly, the third paragraph under "PORTFOLIO MANAGERS." on page 29 is
hereby deleted and replaced with the following:
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Philip W. Friedman is a Managing Director of Morgan
  Stanley and MSAM and is a member of MSAM's investment management team. In
  addition to portfolio management, his equity research responsibilities
  include business equipment and services, capital goods, consumer durables,
  multi-industry and transportation. Prior to joining MSAM in 1997, he was
  the North American Director of Equity Research at Morgan Stanley. From 1990
  to 1995, he was a member of Morgan Stanley's Equity Research team. Mr.
  Friedman graduated from Rutgers University with a B.A. (Phi Beta Kappa and
  Summa Cum Laude) in Economics. He also holds an M.B.A. from the J. L.
  Kellogg School of Management at Northwestern University. Margaret K.
  Johnson is a Principal of MSAM and Morgan Stanley and a Portfolio Manager
  in the Institutional Equity Group. She joined MSAM in 1984. She holds a
  B.A. degree from Yale College and is a Chartered Financial Analyst. William
  S. Auslander is a Vice President of MSAM and Morgan Stanley. He joined MSAM
  in 1995 as an equity analyst in the Institutional Equity Group. Prior to
  joining MSAM, he worked at Icahn & Co. for nine years as an equity analyst.
  He graduated from the University of Wisconsin at Madison with a B.A. in
  Economics and received an M.B.A. from Columbia University. Ms. Johnson has
  shared primary responsibility for managing the Portfolio's assets since its
  inception. Messrs. Friedman and Auslander have shared primary
  responsibility for managing the Portfolio's assets since September 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                        TO PROSPECTUS DATED MAY 1, 1998
 
                            EQUITY GROWTH PORTFOLIO
                          U.S. REAL ESTATE PORTFOLIO
                        INTERNATIONAL MAGNUM PORTFOLIO
                       EMERGING MARKETS EQUITY PORTFOLIO
 
                               PORTFOLIOS OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth Portfolio. Kurt A. Feuerman no
longer serves as a Portfolio Manager of the Equity Growth Portfolio. Philip W.
Friedman and William S. Auslander now share primary responsibility for
managing the assets of the Equity Growth Portfolio with Margaret K. Johnson.
Accordingly, the first paragraph under "PORTFOLIO MANAGERS." on page 22 is
hereby deleted and replaced with the following:
 
    EQUITY GROWTH PORTFOLIO--Philip W. Friedman, Margaret K. Johnson and
  William S. Auslander. Philip W. Friedman is a Managing Director of Morgan
  Stanley and MSAM and is a member of MSAM's investment management team. In
  addition to portfolio management, his equity research responsibilities
  include business equipment and services, capital goods, consumer durables,
  multi-industry and transportation. Prior to joining MSAM in 1997, he was
  the North American Director of Equity Research at Morgan Stanley. From 1990
  to 1995, he was a member of Morgan Stanley's Equity Research team. Mr.
  Friedman graduated from Rutgers University with a B.A. (Phi Beta Kappa and
  Summa Cum Laude) in Economics. He also holds an M.B.A. from the J. L.
  Kellogg School of Management at Northwestern University. Margaret K.
  Johnson is a Principal of MSAM and Morgan Stanley and a Portfolio Manager
  in the Institutional Equity Group. She joined MSAM in 1984. She holds a
  B.A. degree from Yale College and is a Chartered Financial Analyst. William
  S. Auslander is a Vice President of MSAM and Morgan Stanley. He joined MSAM
  in 1995 as an equity analyst in the Institutional Equity Group. Prior to
  joining MSAM, he worked at Icahn & Co. for nine years as an equity analyst.
  He graduated from the University of Wisconsin at Madison with a B.A. in
  Economics and received an M.B.A. from Columbia University. Ms. Johnson has
  shared primary responsibility for managing the Portfolio's assets since its
  inception. Messrs. Friedman and Auslander have shared primary
  responsibility for managing the Portfolio's assets since September 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE
<PAGE>
 
                       SUPPLEMENT DATED OCTOBER 6, 1998
                      TO PROSPECTUS DATED AUGUST 28, 1998
 
                            EQUITY GROWTH PORTFOLIO
 
                                    OF THE
 
                     MORGAN STANLEY UNIVERSAL FUNDS, INC.
                                 P.O. BOX 2798
                             BOSTON, MASSACHUSETTS
                                  02208-2798
 
                               ----------------
 
  The Prospectus is hereby amended and supplemented to reflect changes in the
portfolio management of the Equity Growth Portfolio. Kurt A. Feuerman no
longer serves as a Portfolio Manager of the Equity Growth Portfolio. Philip W.
Friedman and William S. Auslander now share primary responsibility for
managing the assets of the Equity Growth Portfolio with Margaret K. Johnson.
Accordingly, the section "PORTFOLIO MANAGERS." on page 18 is hereby deleted
and replaced with the following:
 
  PORTFOLIO MANAGERS. The following persons have primary responsibility for
the Portfolio.
 
    Philip W. Friedman, Margaret K. Johnson and William S. Auslander. Philip
  W. Friedman is a Managing Director of Morgan Stanley and MSAM and is a
  member of MSAM's investment management team. In addition to portfolio
  management, his equity research responsibilities include business equipment
  and services, capital goods, consumer durables, multi-industry and
  transportation. Prior to joining MSAM in 1997, he was the North American
  Director of Equity Research at Morgan Stanley. From 1990 to 1995, he was a
  member of Morgan Stanley's Equity Research team. Mr. Friedman graduated
  from Rutgers University with a B.A. (Phi Beta Kappa and Summa Cum Laude) in
  Economics. He also holds an M.B.A. from the J. L. Kellogg School of
  Management at Northwestern University. Margaret K. Johnson is a Principal
  of MSAM and Morgan Stanley and a Portfolio Manager in the Institutional
  Equity Group. She joined MSAM in 1984. She holds a B.A. degree from Yale
  College and is a Chartered Financial Analyst. William S. Auslander is a
  Vice President of MSAM and Morgan Stanley. He joined MSAM in 1995 as an
  equity analyst in the Institutional Equity Group. Prior to joining MSAM, he
  worked at Icahn & Co. for nine years as an equity analyst. He graduated
  from the University of Wisconsin at Madison with a B.A. in Economics and
  received an M.B.A. from Columbia University. Ms. Johnson has shared primary
  responsibility for managing the Portfolio's assets since its inception.
  Messrs. Friedman and Auslander have shared primary responsibility for
  managing the Portfolio's assets since September 1998.
 
                               ----------------
 
              PLEASE RETAIN THIS SUPPLEMENT FOR FUTURE REFERENCE


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