DIATIDE INC
S-8, 1999-07-30
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>



      As filed with the Securities and Exchange Commission on July 30, 1999
                                                           Registration No. 333-

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  -------------

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                  DIATIDE, INC.
- --------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in Its Charter)

                                    Delaware
- --------------------------------------------------------------------------------
         (State or Other Jurisdiction of Incorporation or Organization)

                                   04-3078258
- --------------------------------------------------------------------------------
                      (I.R.S. Employer Identification No.)

           Nine Delta Drive, Londonderry, New Hampshire       03053
- --------------------------------------------------------------------------------
           (Address of Principal Executive Offices)         (Zip Code)

                            1999 STOCK INCENTIVE PLAN
- --------------------------------------------------------------------------------
                            (Full Title of the Plan)

                                Dr. Richard Dean
                      President and Chief Executive Officer
                                  Diatide, Inc.
                                Nine Delta Drive
                        Londonderry, New Hampshire 03053
- --------------------------------------------------------------------------------
                     (Name and Address of Agent for Service)

                                 (603) 437-8970
- --------------------------------------------------------------------------------
          (Telephone Number, Including Area Code, of Agent for Service)

<TABLE>
<CAPTION>


                         CALCULATION OF REGISTRATION FEE
- -------------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------------
       Title of                                         Proposed                Proposed
      Securities                 Amount                  Maximum                 Maximum                Amount of
         to be                    to be              Offering Price             Aggregate              Registration
      Registered               Registered               Per Share            Offering Price                Fee
- -------------------------------------------------------------------------------------------------------------------
<S>                         <C>                         <C>                  <C>                       <C>
Common Stock,               2,500,000 shares            $4.50 (1)            $11,250,000 (1)              $3,128
$.001 par value
per share
- -------------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------------
</TABLE>


(1)      Estimated solely for the purpose of calculating the registration fee,
         and based upon the average of the high and low prices of the Common
         Stock as reported on the Nasdaq National Market on July 26, 1999 in
         accordance with Rules 457(c) and 457(h) of the Securities Act of 1933,
         as amended.


<PAGE>



PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

         The information required by Part I is included in documents sent or
given to participants in the 1999 Stock Incentive Plan of Diatide, Inc. (the
"Registrant") pursuant to Rule 428(b)(1) of the Securities Act of 1933, as
amended (the "Securities Act").

PART II.  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE.

         The Registrant is subject to the informational and reporting
requirements of Sections 13(a), 14, and 15(d) of the Securities Exchange Act of
1934 as amended, (the "Exchange Act"), and in accordance therewith files
reports, proxy statements and other information with the Securities and Exchange
Commission (the "Commission"). The following documents, which are filed with the
Commission, are incorporated in this registration statement by reference:

         (1)      The Registrant's latest annual report filed pursuant to
                  Section 13(a) or 15(d) of the Exchange Act or the latest
                  prospectus filed pursuant to Rule 424(b) under the Securities
                  Act that contains, either directly or by incorporation by
                  reference, audited financial statements for the Registrant's
                  latest fiscal year for which such statements have been filed.

          (2)     All other reports filed pursuant to Section 13(a) or 15(d) of
                  the Exchange Act since the end of the fiscal year covered by
                  the annual reports or the prospectus referred to in (1) above.

          (3)     The description of the common stock of the Registrant, par
                  value $.001 per share ("Common Stock"), contained in the
                  Registrant's registration statement on Form 8-A filed under
                  the Exchange Act, including any amendment or report filed for
                  the purpose of updating such description.

         All documents subsequently filed by the Registrant pursuant to Sections
13(a), 13(c), 14, and 15(d) of the Exchange Act prior to the filing of a
post-effective amendment which indicates that all shares of Common Stock offered
hereby have been sold or which deregisters all shares of Common Stock then
remaining unsold, shall be deemed to be incorporated by reference herein and to
be part hereof from the date of the filing of such documents. Any statement
contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or supersede for the purposes of this
registration statement to the extent a statement contained herein or in any
other subsequently filed document which also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any statement so
modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this registration statement.



<PAGE>



ITEM 4. DESCRIPTION OF SECURITIES.

         Not applicable.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

         Not applicable.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Article EIGHTH of the Registrant's Restated Certificate of
Incorporation provides that no director of the Registrant shall be personally
liable for any monetary damages for any breach of fiduciary duty as a director,
except to the extent that the Delaware General Corporation law prohibits the
elimination or limitation of liability of directors for breach of fiduciary
duty.

         Article NINTH of the Registrant's Restated Certificate of Incorporation
provides that a director or officer of the Registrant (a) shall be indemnified
by the Registrant against all expenses (including attorneys' fees), judgments,
fines and amounts paid in settlement incurred in connection with any litigation
or other legal proceeding (other than an action by or in the right of the
Registrant) brought against him by virtue of his position as a director or
officer of the Registrant if he acted in good faith and in a manner he
reasonably believed to be in, or not opposed to, the best interests of the
Registrant, and, with respect to any criminal action or proceeding, has no
reasonable cause to believe his conduct was unlawful and (b) shall be
indemnified by the Registrant against all expenses (including attorneys' fees)
and amounts paid in settlement incurred in connection with any action by or in
the right of the Registrant brought against him by virtue of his position as a
director or officer of the Registrant if he acted in good faith and in a manner
he reasonably believed to be in, or not opposed to, the best interests of the
Registrant, except that no indemnification shall be made with respect to any
matter as to which such person shall have been adjudged to be liable to the
Registrant, unless a court determines that, despite such adjudication but in
view of all of the circumstances, he is entitled to indemnification of such
expenses. Notwithstanding the foregoing, to the extent that a director or
officer has been successful, on the merits or otherwise, including, without
limitation, the dismissal of an action without prejudice, he is required to be
indemnified by the Registrant against all expenses (including attorneys' fees)
incurred in connection therewith. Expenses shall be advanced to a Director or
officer at his request, provided that he undertakes to repay the amount advanced
if it is ultimately determined that he is not entitled to indemnification for
such expenses.

         Indemnification is required to be made unless the Registrant determines
that the applicable standard of conduct required for indemnification has not
been met. In the event of a determination by the Registrant that the director or
officer did not meet the applicable standard of conduct required for
indemnification, or if the Registrant fails to make an indemnification payment
within 60 days after such payment is claimed by such person, such person is
permitted to petition the court to make an independent determination as to
whether such person is entitled to indemnification. As a condition precedent to
the right of


<PAGE>



indemnification, the director or officer must give the Registrant notice of the
action for which indemnity is sought and the Registrant has the right to
participate in such action or assume the defense thereof.

         Article NINTH of the Registrant's Restated Certificate of Incorporation
further provides that the indemnification provided therein is not exclusive, and
provides that in the event that the Delaware General Corporation Law is amended
to expand the indemnification permitted to directors or officers the Registrant
must indemnify those persons to the full extent permitted by such law as so
amended.

         Section 145 of the Delaware General Corporation Law provides that a
corporation has the power to indemnify a director, officer, employee or agent of
the corporation and certain other persons serving at the request of the
corporation in related capacities against amounts paid and expenses incurred in
connection with an action or proceeding to which he is or is threatened to be
made a party by reason of such position, if such person shall have acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests of the corporation, and, in any criminal proceeding, if such person
had no reasonable cause to believe his conduct was unlawful; provided that, in
the case of actions brought by or in the right of the corporation no
indemnification shall be made with respect to any matter as to which such person
shall have been adjudged to be liable to the corporation unless and only to the
extent that the adjudicating court determines that such indemnification is
proper under the circumstances.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

         Not applicable.

ITEM 8. EXHIBITS.

         The Exhibit Index immediately preceding the exhibits is incorporated
herein by reference.

ITEM 9. UNDERTAKINGS.

         1.       The Registrant hereby undertakes:

                  (a)      To file, during any period in which offers or sales
                           are being made, a post-effective amendment to this
                           registration statement:

                           (i)      To include any prospectus required by
                                    Section 10(a)(3) of the Securities Act;

                           (ii)     To reflect in the prospectus any facts or
                                    events arising after the effective date of
                                    the registration statement (or the most
                                    recent post-effective amendment thereof)
                                    which, individually or in the aggregate,
                                    represent a fundamental change in the
                                    information set


<PAGE>


                                    forth in the registration statement.
                                    Notwithstanding the foregoing, any increase
                                    or decrease in volume of securities offered
                                    (if the total dollar value of securities
                                    offered would not exceed that which was
                                    registered) and any deviation from the low
                                    or high end of the estimated maximum
                                    offering range may be reflected in the form
                                    of prospectus filed with the Commission
                                    pursuant to Rule 424(b) if, in the
                                    aggregate, the changes in volume and price
                                    represent no more than a 20% change in the
                                    maximum aggregate offering price set forth
                                    in the "Calculation of Registration Fee"
                                    table in the effective registration
                                    statement; and

                           (iii)    To include any material information with
                                    respect to the plan of distribution not
                                    previously disclosed in the registration
                                    statement or any material change to such
                                    information in the registration statement;

                           PROVIDED HOWEVER, that paragraphs (a)(i) and (a)(ii)
                           do not apply if the registration statement is on Form
                           S-3, Form S-8 or Form F-3, and the information
                           required to be included in a post-effective amendment
                           by those paragraphs is contained in periodic reports
                           filed with or furnished to the Commission by the
                           Registrant pursuant to Section 13 or Section 15(d) of
                           the Exchange Act that are incorporated by reference
                           in the registration statement.

                  (b)      That, for the purpose of determining any liability
                           under the Securities Act, each such post-effective
                           amendment shall be deemed to be a new registration
                           statement relating to the securities offered therein,
                           and the offering of such securities at that time
                           shall be deemed to be the initial bona fide offering
                           thereof.

                  (c)      To remove from registration by means of a
                           post-effective amendment any of the securities being
                           registered which remain unsold at the termination of
                           the offering.

         2.       The Registrant hereby undertakes that, for purposes of
                  determining any liability under the Securities Act, each
                  filing of the Registrant's annual report pursuant to Section
                  13(a) or Section 15(d) of the Exchange Act (and, where
                  applicable, each filing of an employee benefit plan's annual
                  report pursuant to Section 15(d) of the Exchange Act) that is
                  incorporated by reference in the registration statement shall
                  be deemed to be a new registration statement relating to the
                  securities offered therein, and the offering of such
                  securities at that time shall be deemed to be in the initial
                  bona fide offering thereof.

         3.       Insofar as indemnification for liabilities arising under the
                  Securities Act may be permitted to directors, officers and
                  controlling persons of the Registrant


<PAGE>


                  pursuant to the foregoing provisions, or otherwise, the
                  Registrant has been advised that in the opinion of the
                  Commission such indemnification is against public policy as
                  expressed in the Securities Act and is, therefore,
                  unenforceable. In the event that a claim for indemnification
                  against such liabilities (other than the payment by the
                  Registrant of expenses incurred or paid by a director, officer
                  or controlling person of the Registrant in the successful
                  defense of any action, suit or proceeding) is asserted by such
                  director, officer or controlling person in connection with the
                  securities being registered, the Registrant will, unless in
                  the opinion of its counsel the matter has been settled by
                  controlling precedent, submit to a court of appropriate
                  jurisdiction the question whether such indemnification by it
                  is against public policy as expressed in the Securities Act
                  and will be governed by the final adjudication of such issue.



<PAGE>



                                   SIGNATURES

         Pursuant to the requirements of the Securities Act, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Londonderry, New Hampshire on the 30th day of July,
1999.

                                               DIATIDE, INC.


                                               By: /s/ Richard T. Dean
                                                   -----------------------------
                                                   Richard T. Dean
                                                   President and Chief Executive
                                                   Officer

                                POWER OF ATTORNEY

         We, the undersigned officers and directors of Diatide, Inc. hereby
severally constitute Richard T. Dean, Ronald B. Kinder, David E. Redlick, and
Stuart M. Falber, and each of them singly, our true and lawful attorneys with
full power to them, and each of them singly, to sign for us and in our names in
the capacities indicated below, the registration statement on Form S-8 filed
herewith and any and all subsequent amendments to said registration statement,
and generally to do all such things in our names and behalf in our capacities as
officers and directors to enable Diatide, Inc. to comply with all requirements
of the Securities and Exchange Commission, hereby ratifying and confirming our
signatures as they may be signed by said attorneys, or any of them, to said
registration statement and any and all amendments thereto.

         Pursuant to the requirements of the Securities Act, this registration
statement has been signed below by the following persons in the capacities
indicated below and on the dates indicated.

<TABLE>
<CAPTION>

Signature                                Title                                               Date
- ---------                                -----                                               ----
<S>                                      <C>                                                 <C>
/s/  Richard T. Dean                     President, Chief Executive Officer and              July 30, 1999
- -----------------------------            Director (Principal Executive, Financial
Richard T. Dean                          and Accounting Officer)

</TABLE>



<PAGE>


<TABLE>

<S>                                      <C>                                                 <C>
/s/ Robert S. Lees                       Director                                            July 30, 1999
- -----------------------------
Robert S. Lees



/s/ Gustav A. Christensen                Director                                            July 30, 1999
- -----------------------------
Gustav A. Christensen



/s/ Donald L. Murfin                     Director                                            July 30, 1999
- -----------------------------
Donald L. Murfin



/s/ Hirsch Handmaker                     Director                                            July 30, 1999
- -----------------------------
Hirsch Handmaker



/s/ Joseph F. Lovett                     Director                                            July 30, 1999
- -----------------------------
Joseph F. Lovett

</TABLE>


<PAGE>



                                INDEX TO EXHIBITS

<TABLE>
<CAPTION>

NUMBER            DESCRIPTION
- ------            -----------
<S>               <C>
3.1(1)            Restated Certificate of Incorporation of the Registrant

3.2(2)            Amended and Restated By-laws of the Registrant

4.1(2)            Specimen Stock Certificate of Common Stock of the Registrant

5.1               Opinion of Hale and Dorr LLP, counsel to the Registrant

23.1              Consent of Hale and Dorr LLP (included in Exhibit 5.1)

23.2              Consent of Ernst & Young LLP

24.1              Power of Attorney (included in the signature pages of this
                  Registration Statement)

</TABLE>

- ----------------
(1)      Previously filed with the Commission as an Exhibit to the Registrant's
         Current Report on Form 8-K dated January 25, 1999 (File No. 000-28434).

(2)      Previously filed with the Commission as an Exhibit to the Registrant's
         Registration Statement on Form S-1, as amended (File No. 333-3326).










<PAGE>



                                                                     EXHIBIT 5.1

                   [Letterhead of Hale and Dorr appears here]

                                                      July 30, 1999


Diatide, Inc.
Nine Delta Drive
Londonderry, New Hampshire 03053

         Re:      1999 STOCK INCENTIVE PLAN
                  -------------------------

Ladies and Gentlemen:

         We have assisted in the preparation of a Registration Statement on Form
S-8 (the Registration Statement") to be filed with the Securities and Exchange
Commission relating to 2,500,000 shares (the "Shares") of Common Stock, $.001
par value per share, of Diatide, Inc., a Delaware corporation (the "Company"),
issuable under the Company's 1999 Stock Incentive Plan (the "Plan").

         We have examined the Restated Certificate of Incorporation of the
Company, the Amended and Restated By-laws of the Company, and originals, or
copies certified to our satisfaction, of all pertinent records of the meetings
of the directors and stockholders of the Company, the Registration Statement and
such other documents relating to the Company as we have deemed material for the
purposes of this opinion.

         In examination of the foregoing documents, we have assumed the
genuineness of all signatures and the authenticity of all documents submitted to
us as originals, the conformity to original documents of all documents submitted
to us as certified, photostatic or facsimile copies, and the authenticity of the
originals of any such documents.

         Based on the foregoing, we are of the opinion that the Shares have been
duly authorized for issuance under the Plan, and the Shares, when issued and
paid for in accordance with the terms of the Plan and at a price per share in
excess of the par value per share for such Shares, will be legally issued, fully
paid and nonassessable.

         We hereby consent to the filing of this opinion with the Securities and
Exchange Commission in connection with the Registration Statement.

                                            Very truly yours,

                                            /s/ HALE AND DORR LLP
                                            ---------------------
                                            HALE AND DORR LLP


<PAGE>



                                                                    EXHIBIT 23.2


                         CONSENT OF INDEPENDENT AUDITORS

        We consent to the incorporation by reference in the Registration
Statement (Form S-8) pertaining to the 1999 Stock Incentive Plan of Diatide,
Inc. of our report dated February 9, 1999, with respect to the financial
statements of Diatide, Inc. included in its Annual Report (Form 10- K) for the
year ended December 31, 1998, filed with the Securities and Exchange Commission.

                                        /s/ ERNST & YOUNG LLP
                                        ---------------------
                                        ERNST & YOUNG LLP

Manchester, New Hampshire
July 28, 1999





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