DIATIDE INC
SC 13G, 1999-01-28
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                           (Amendment No.___________)*

                                  DIATIDE, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                     COMMON STOCK, PAR VALUE $.001 PER SHARE
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   252842-10-9
                   ------------------------------------------
                                 (CUSIP Number)


                                JANUARY 19, 1999
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

       [ ]    Rule 13d-1(b)

       [X]    Rule 13d-1(c)

       [ ]    Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                  Page 1 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Alta Partners
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    California

- ----------------------------------------------------------------------------------------------------------------

Number of         5.  Sole Voting Power           825,309
Shares Bene-      ----------------------------------------------------------------------------------------------
ficially Owned    6.  Shared Voting Power         0
by Each           ----------------------------------------------------------------------------------------------
Reporting         7.  Sole Dispositive Power      825,309
Person With:      ----------------------------------------------------------------------------------------------
                  8.  Shared Dispositive Power    0

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)   7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions) IA, CO

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 2 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Alta BioPharma Partners, L.P.
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    Delaware

- ----------------------------------------------------------------------------------------------------------------

Number of         5.  Sole Voting Power              795,332
Shares Bene-      ----------------------------------------------------------------------------------------------
ficially Owned    6.  Shared Voting Power            0
by Each           ----------------------------------------------------------------------------------------------
Reporting         7.  Sole Dispositive Power         795,332
Person With:      ----------------------------------------------------------------------------------------------
                  8.  Shared Dispositive Power       0

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person             795,332


       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)...............

       11.   Percent of Class Represented by Amount in Row (11)                  7.0%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)       PN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 3 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Alta Embarcadero BioPharma Partners, LLC
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    Delaware

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           29,977
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         0
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      29,977
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    0

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               29,977


       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         0.3%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)       CO

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 4 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Alta BioPharma Management, LLC
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    Delaware

- ----------------------------------------------------------------------------------------------------------------

Number of         5.  Sole Voting Power           825,309
Shares Bene-      ----------------------------------------------------------------------------------------------
ficially Owned    6.  Shared Voting Power         0
by Each           ----------------------------------------------------------------------------------------------
Reporting         7.  Sole Dispositive Power      825,309
Person With:      ----------------------------------------------------------------------------------------------
                  8.  Shared Dispositive Power    0

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)           CO

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 5 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Jean Deleage
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power            46,472
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power       46,472
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               871,781

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.6%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions) IN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>
                                                  Page 6 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Garrett Gruener
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           0
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      0
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309



       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions) IN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>
                                                  Page 7 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Daniel Janney
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           0
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      0
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See  Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions) IN .

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 8 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Alix Marduel
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           0
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      0
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)      IN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                  Page 9 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Guy Nohra
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           0
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      0
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)      IN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                 Page 10 of 15

<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  252842-10-9
- ----------------------------------------------------------------------------------------------------------------
<S>    <C>        <C>                             <C>

       1.    Names of Reporting Persons.
             I.R.S. Identification Nos. of above persons (entities only).

             Marino Polestra
- ----------------------------------------------------------------------------------------------------------------

       2.    Check the Appropriate Box if a Member of a Group (See Instructions)

             (a)
             (b)
- ----------------------------------------------------------------------------------------------------------------

       3.    SEC Use Only.

- ----------------------------------------------------------------------------------------------------------------

       4.    Citizenship or Place of Organization    USA

- ----------------------------------------------------------------------------------------------------------------

Number of        5.  Sole Voting Power           0
Shares Bene-     ----------------------------------------------------------------------------------------------
ficially Owned   6.  Shared Voting Power         825,309
by Each          ----------------------------------------------------------------------------------------------
Reporting        7.  Sole Dispositive Power      0
Person With:     ----------------------------------------------------------------------------------------------
                 8.  Shared Dispositive Power    825,309

- ----------------------------------------------------------------------------------------------------------------

       9.    Aggregate Amount Beneficially Owned by Each Reporting Person               825,309

       10.   Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions).............

       11.   Percent of Class Represented by Amount in Row (11)         7.2%

- ----------------------------------------------------------------------------------------------------------------

       12.   Type of Reporting Person (See Instructions)      IN

- ----------------------------------------------------------------------------------------------------------------
</TABLE>

                                                 Page 11 of 15

<PAGE>


Item 1.

       (a) Name of Issuer

             DIATIDE, INC.

       (b) Address of Issuer's Principal Executive Offices

             Nine Delta Drive
             Londonderry, New Hampshire   03053

Item 2.

       (a) Name of Person Filing

             Alta Partners;  Alta BioPharma  Partners,  L.P.;  Alta  Embarcadero
             BioPharma  Partners,  LLC;  Alta  BioPharma  Management,  LLC; Jean
             Deleage;  Garrett Gruener;  Daniel Janney; Alix Marduel; Guy Nohra;
             Marino Polestra

       (b) Address of Principal Business Office or, if none, Residence

             The business  address of all persons  jointly  filing this Schedule
13G is:

             One Embarcadero Center, Suite 4050
             San Francisco, California 94111

       (c) Citizenship

             See Item 4. of cover pages

       (d) Title of Class of Securities

             Common Stock, par value $.001 per share

       (e) CUSIP Number

             252842-10-9

Item  3.  If  this  statement  is  filed  pursuant  to   ss.ss.240.13d-1(b)   or
          240.13d-2(b) or (c), check whether the person filing is a:

       (a)  [ ]   Broker or dealer  registered  under  section 15 of the Act (15
                  U.S.C. 78o);.

       (b)  [ ]   Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

       (c)  [ ]   Insurance  company as defined in section  3(a)(19)  of the Act
                  (15 U.S.C. 78c);

       (d)  [ ]   Investment   company   registered   under  section  8  of  the
                  Investment Company Act of 1940 (15 U.S.C. 80a-8);

       (e)  [ ]   An     investment      advisor     in     accordance      with
                  ss.240.13d-1(b)(1)(ii)(E);

                                 Page 12 of 15

<PAGE>

       (f)  [ ]   An employee  benefit plan or endowment fund in accordance with
                  ss.240.13d-1(b)(1)(ii)(F);

       (g)  [ ]   A parent holding company or control person in accordance with
                  ss.240.13d-1(b)(1)(ii)(G);

       (h)  [ ]   A  savings  association  as  defined  in  Section  3(b) of the
                  Federal Deposit Insurance Act (12 U.S.C. 1813);

       (i)  [ ]   A church  plan  that is  excluded  from the  definition  of an
                  investment  company under section  3(c)(14) of the  Investment
                  Company Act of 1940 (15 U.S.C. 80a-3);

       (j)  [ ]   Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

Item 4. Ownership

       Provide the following  information  regarding  the  aggregate  number and
percentage of the class of securities of the issuer identified in Item 1.

       (a) Amount  beneficially  owned:  871,781:  See Item 9 of cover pages for
           details as to each person filing this Schedule 13G.

       (b) Percent of class:  7.6%: See Item 11 of cover pages for details as to
           each person filing this Schedule 13G.

       (c) Number of shares as to which the person has:

         (i)      Sole power to vote or to direct the vote:  See Item 5 of cover
                  pages for details as to each person filing this Schedule 13G.

         (ii)     Shared  power to vote or to  direct  the  vote:  See Item 6 of
                  cover pages for details as to each person filing this Schedule
                  13G.

         (iii)    Sole power to dispose  or to direct  the  disposition  of: See
                  Item 7 of cover  pages for  details as to each  person  filing
                  this Schedule 13G.

         (iv)     Shared power to dispose or to direct the  disposition  of: See
                  Item 8 of cover  pages for  details as to each  person  filing
                  this Schedule 13G.

       Instruction.  For  computations  regarding  securities  which represent a
right to acquire an underlying security see ss.240.13d-3(d)(1).

Item 5.  Ownership of Five Percent or Less of a Class

       If this  statement  is being filed to report the fact that as of the date
hereof the reporting  person has ceased to be the beneficial  owner of more than
five percent of the class of securities, check the following. [ ]

Item 6.  Ownership of More than Five Percent on Behalf of Another Person.

         Not Applicable

Item 7.  Identification  and Classification of the Subsidiary Which Acquired the
         Security Being Reported on By the Parent Holding Company.

       This Statement is filed jointly by Alta BioPharma  Partners,  L.P. ("Alta
BioPharma") and Alta Embarcadero BioPharma Partners, LLC ("Embarcadero LLC"), by
virtue  of their  direct  beneficial  ownership  of  825,309  shares of Series B
Convertible  Preferred Stock that are currently  convertible into 825,309 shares
of the Common Stock of Diatide,  Inc.  reported hereby (the  "Shares");  by Alta
BioPharma Management Partners,  LLC ("Alta Management"),  by virtue of being the
sole general partner of Alta BioPharma;  and by Alta Partners ("Alta Partners"),
by virtue of being the  management  advisory  company  of these  entities.  Jean
Deleage,  Garrett  Gruener,  Dan  Janney,  Alix  Marduel,  Guy Nohra and  Marino
Polestra are the  managing  directors  of Alta  Management  and officers of Alta
Partners (the "Partners").  By 

                                 Page 13 of 15

<PAGE>

virtue of the relationships  described above and their roles with Alta Partners,
each of the Partners may be deemed to control Alta Partners and Alta Management,
and, therefore,  may be deemed to possess indirect  beneficial  ownership of the
Shares held by each entity.  However,  none of the Partners,  acting alone,  has
voting or investment power with respect to the Shares directly beneficially held
by the entities and, as a result, the Partners disclaim beneficial  ownership of
the Shares directly  beneficially owned by each entity,  except to the extent of
their pecuniary interest in each entity. Jean Deleage  individually holds 46,472
shares of Diatide  Inc.'s Common Stock.  Embarcadero  LLC is a side company that
makes  all  investments  pro  rata to the  capital  of Alta  BioPharma  with all
allocations  made to its  members  based  on  paid-in  capital.  Certain  of the
Partners are members of Embarcadero  LLC and certain  members of Embarcadero LLC
are affiliates of Alta Partners.

Item 8.  Identification and Classification of Members of the Group

         Not Applicable

Item 9.  Notice of Dissolution of Group

         Not Applicable

Item 10. Certification

       By signing  below I certify that, to the best of my knowledge and belief,
the  securities  referred  to above were not  acquired  and are not held for the
purpose of or with the effect of  changing  or  influencing  the  control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.

                                   SIGNATURES

       After  reasonable  inquiry and to the best of my knowledge and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.

Date: January 27, 1999

ALTA PARTNERS                                     ALTA BIOPHARMA PARTNERS, L.P.
                                                  By:      Alta BioPharma
                                                           Management, LLC,
                                                           Its General Partner

By:        /s/ Eileen McCarthy                    By:        /s/ Eileen McCarthy
- -----------------------------------               ------------------------------
   Eileen McCarthy, Vice President                    Eileen McCarthy, Member

ALTA EMBARCADERO BIOPHARMA PARTNERS,              ALTA BIOPHARMA MANAGEMENT, LLC
LLC

By:        /s/ Eileen McCarthy                    By:        /s/ Eileen McCarthy
- -----------------------------------               ------------------------------
    Eileen McCarthy, Member                           Eileen McCarthy, Member


           /s/ Jean Deleage                                  /s/ Garrett Gruener
- -----------------------------------               ------------------------------
Jean Deleage                                       Garrett Gruener


           /s/ Daniel Janney                                 /s/ Alix Marduel
- -----------------------------------               ------------------------------
Daniel Janney                                      Alix Marduel


           /s/ Guy Nohra                                     /s/ Marino Polestra
- -----------------------------------               ------------------------------
Guy Nohra                                          Marino Polestra

                                 Page 14 of 15

<PAGE>

                                    EXHIBIT A

                             Joint Filing Statement

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13G is filed on behalf of each of us.


Date: January 27, 1999

ALTA PARTNERS                                     ALTA BIOPHARMA PARTNERS, L.P.
                                                  By:      Alta BioPharma
                                                           Management, LLC,
                                                           Its General Partner

By:        /s/ Eileen McCarthy                    By:        /s/ Eileen McCarthy
- -----------------------------------               ------------------------------
   Eileen McCarthy, Vice President                    Eileen McCarthy, Member

ALTA EMBARCADERO BIOPHARMA PARTNERS,              ALTA BIOPHARMA MANAGEMENT, LLC
LLC

By:        /s/ Eileen McCarthy                    By:        /s/ Eileen McCarthy
- -----------------------------------               ------------------------------
    Eileen McCarthy, Member                           Eileen McCarthy, Member


           /s/ Jean Deleage                                  /s/ Garrett Gruener
- -----------------------------------               ------------------------------
Jean Deleage                                       Garrett Gruener


           /s/ Daniel Janney                                 /s/ Alix Marduel
- -----------------------------------               ------------------------------
Daniel Janney                                      Alix Marduel


           /s/ Guy Nohra                                     /s/ Marino Polestra
- -----------------------------------               ------------------------------
Guy Nohra                                          Marino Polestra

                                 Page 15 of 15



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