NOVOSTE CORP /FL/
5, 2000-02-14
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 5

               ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

[_]  Check box if no longer  subject to Section 16. Form 4 or Form 5 obligations
     may continue. See Instruction 1(b).

[_]  Form 3 Holdings Reported

[_]  Form 4 Transactions Reported

________________________________________________________________________________
1.   Name and Address of Reporting Person*

  Harrison                           Donald                  C.
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   (Last)                            (First)              (Middle)

U. of Cincinnati Medical Center
250 Health Professions Building
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                                    (Street)

Cincinnati                             Ohio                 45267
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   (City)                            (State)                (Zip)
________________________________________________________________________________
2.   Issuer Name and Ticker or Trading Symbol

Novoste Corporation (NOVT)

________________________________________________________________________________
3.   IRS Identification Number of Reporting Person, if an Entity (Voluntary)



________________________________________________________________________________
4.   Statement for Month/Year

December 1999

________________________________________________________________________________
5.   If Amendment, Date of Original (Month/Year)



________________________________________________________________________________
6.   Relationship of Reporting Person to Issuer
     (Check all applicable)

     [X]  Director                             [_]  10% Owner
     [_]  Officer (give title below)           [_]  Other (specify below)

________________________________________________________________________________
7.   Individual or Joint/Group Filing
     (Check applicable line)

     [X]  Form filed by one Reporting Person
     [_]  Form filed by more than one Reporting Person
________________________________________________________________________________


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           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
================================================================================
<TABLE>
<CAPTION>
                                                                                                 5.             6.
                                                                 4.                              Amount of      Owner-
                                                                 Securities Acquired (A) or      Securities     ship
                                                                 Disposed of (D)                 Beneficially   Form:     7.
                                                                 (Instr. 3, 4 and 5)             Owned at End   Direct    Nature of
                                      2.            3.           -----------------------------   of Issuer's    (D) or    Indirect
1.                                    Transaction   Transaction                  (A)             Fiscal Year    Indirect  Beneficial
Title of Security                     Date          Code             Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)    (Instr. 8)                   (D)             and 4)         (Instr.4) (Instr. 4)
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<S>                                   <C>            <C>             <C>         <C>    <C>      <C>            <C>       <C>


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</TABLE>

Reminder:  Report on a separate line for each class of  securities  beneficially
owned directly or indirectly.


                                                                          (Over)
(Form 5-07/99)

<PAGE>


FORM 5 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
         (e.g., puts, calls, warrants, options, convertible securities)

================================================================================
<TABLE>
<CAPTION>
                                                                                                            9.        10.
                                                                                                            Number    Owner-
                                                                                                            of        ship
                2.                                                                                        Deriv-    of
                Conver-                      5.                                  7.                         ative     Deriv-  11.
                sion                         Number of                           Title and Amount           Secur-    ative   Nature
                or                           Derivative     6.                   of Underlying     8.       ities     Secur-  of
                Exer-                        Securities     Date                 Securities        Price    Bene-     ity:    In-
                cise     3.                  Acquired (A)   Exercisable and      (Instr. 3 and 4)  of       ficially  Direct  direct
                Price    Trans-     4.       or Disposed    Expiration Date      ----------------  Deriv-   Owned     (D) or  Bene-
1.              of       action     Trans-   of (D)         (Month/Day/Year)               Amount  ative    at End    In-     ficial
Title of        Deriv-   Date       action   (Instr. 3,    ------------------              or      Secur-   of        direct  Owner-
Derivative      ative    (Month/    Code     4 and 5)      Date        Expira-             Number  ity      Year      (I)     ship
Security        Secur-   Day/       (Instr.  ------------  Exer-       tion                of      (Instr.  (Instr.   (Instr. (Instr
(Instr. 3)      ity      Year)      8)        (A)   (D)    cisable     Date      Title     Shares  5)       4)        4)      4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>             <C>      <C>        <C>       <C>   <C>    <C>         <C>       <C>       <C>     <C>      <C>       <C>     <C>
Stock Option                                                                     Common
(Right to Buy)  $13.75   11/12/99   A         V     5,000  3/31/01(1)  11/12/04  Stock     5,000            5,000     D

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====================================================================================================================================
</TABLE>
Explanation of Responses:

(1) Options vest in full on the earlier of (i) the date of the 2001 Annual
Meeting of Shareholders or (ii) 3/31/01



/s/ Donald C. Harrison, MD                                  February 14, 2000
- ---------------------------------------------            -----------------------
    Donald C. Harrison, MD                                        Date

**   Intentional misstatements or omissions of facts constitute Federal Criminal
     Violations.

     SEE 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:  File three copies of this form, one of which must be manually signed.
       If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Member.


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