ONYX PHARMACEUTICALS INC
10-Q, 1997-08-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>



                       U.S. SECURITIES AND EXCHANGE COMMISSION
                               WASHINGTON, D.C.  20549
                             ____________________________

                                      FORM 10-Q


( X )    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 1997

                                          OR

(   )    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934

For the transition period from _________________to______________


Commission File Number:  0-28298
                         -------


                              ONYX PHARMACEUTICALS, INC.
                (Exact name of registrant as specified in its charter)

Delaware                                         94-3154463
- -------------------------------             ------------------------
(State or other jurisdiction of             (IRS Employer ID Number)
incorporation or organization)

                                 3031 Research Drive
                             Richmond, California  94806
                       (Address of principal executive offices)

                                    (510) 222-9700
                 (Registrant's telephone number including area code)

Check whether the issuer (1) filed all reports required to be filed by Section
13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been
subject to such filing requirements for the past 90 days.  
         (XX)   Yes                    (   )   No

The number of outstanding shares of the registrant's Common Stock, $0.001 par
value, was 9,809,057 as of July 31, 1997.

<PAGE>

                          ONYX PHARMACEUTICALS, INC.

                                     INDEX


PART I:  FINANCIAL INFORMATION

                                                                         PAGE

ITEM 1.     Financial Statements

              Condensed balance sheets - June 30, 1997 and
               December 31, 1996                                           3

              Condensed statements of operations - three and six months 
               ended June 30, 1997 and 1996                                4

              Condensed statements of cash flows - six months ended
               June 30, 1997 and 1996                                      5

              Notes to condensed financial statements                      6

ITEM 2.     Management's discussion and analysis of financial
             condition and results of operations                           9



PART II:  OTHER INFORMATION

ITEM 2.     Changes in Securities                                        13

ITEM 4.     Submission of Matters to a Vote of Security Holders          13

ITEM 6.     Exhibits and Reports on Form 8-K                             13

SIGNATURES                                                               14

EXHIBIT INDEX                                                            15

                                       2
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

PART I:  FINANCIAL INFORMATION

ITEM 1:  FINANCIAL STATEMENTS

                            CONDENSED BALANCE SHEETS
                       (In thousands, except share data)


<TABLE>
<CAPTION>
                                                         June 30,     December 31,
                                                           1997           1996
                                                        -----------   ------------
                                                        (unaudited)
<S>                                                     <C>           <C>
ASSETS
  Current assets:
    Cash and cash equivalents                             $  7,152    $ 36,258 
    Short-term investments                                  30,370       4,071 
    Other current assets                                       618         638 
                                                          --------    --------
  Total current assets                                      38,140      40,967 

  Property and equipment, net                                4,061       4,196 
  Notes receivable from related parties                        800         396 
  Other assets                                                 209         220 
                                                          --------    --------
TOTAL ASSETS                                              $ 43,210    $ 45,779 
                                                          --------    --------
                                                          --------    --------

LIABILITIES AND STOCKHOLDERS' EQUITY
  Current liabilities:
    Accounts payable                                      $    786    $    693 
    Accrued liabilities                                      2,346       1,277 
    Accrued compensation                                       476         439 
    Deferred revenue                                           846       1,631 
    Long-term debt, current portion                            270         444 
                                                          --------    --------
  Total current liabilities                                  4,724       4,484 
  Long-term debt, noncurrent portion                             -          99 
  Deferred rent                                                154         273 

  Stockholders' equity:
  Preferred stock, $0.001 par value; 5,000,000 shares
  authorized, none issued and outstanding                        -           - 
  Common stock, $0.001 par value: 25,000,000 shares 
  authorized, 9,805,395 and 9,514,285 shares issued 
  and outstanding as of June 30, 1997 and December 31, 
  1996, respectively                                            10          10
  Additional paid-in capital                                74,682      71,132
  Deferred compensation                                       (522)       (632)
  Accumulated deficit                                      (35,838)    (29,587)
                                                          --------    --------
  Total stockholders' equity                                38,332      40,923
                                                          --------    --------
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                $ 43,210    $ 45,779
                                                          --------    --------
                                                          --------    --------
</TABLE>

                            See accompanying notes.

                                       3
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

                      CONDENSED STATEMENTS OF OPERATIONS
                   (In thousands, except per share amounts)
                                 (unaudited)

<TABLE>
<CAPTION>
                                                   Three Months Ended   Six Months Ended
                                                        June 30,            June 30, 
                                                   ------------------   -----------------
                                                      1997      1996      1997      1996
                                                   --------   -------   -------   -------
<S>                                                <C>        <C>       <C>       <C>
Revenue:
  Contract and other revenue                       $    303   $    88   $   610   $   250
  Contract revenue from related parties               1,845     1,812     3,690     3,624
                                                   --------   -------   -------   -------
Total revenue                                         2,148     1,900     4,300     3,874

Operating expenses:
  Research and development                            5,103     3,541     8,980     7,083 
  General and administrative                          1,327     1,058     2,593     1,913 
                                                   --------   -------   -------   -------
Total operating expenses                              6,430     4,599    11,573     8,996 
                                                   --------   -------   -------   -------

Loss from operations                                 (4,282)   (2,699)   (7,273)   (5,122)

Interest income, net                                    524       332     1,022       462 
                                                   --------   -------   -------   -------

Net loss                                           $ (3,758)  $(2,367)  $(6,251)  $(4,660)
                                                   --------   -------   -------   -------
                                                   --------   -------   -------   -------

Net loss per share                                 $  (0.39)            $ (0.65)
                                                   --------             -------
                                                   --------             -------

Shares used in computing net loss 
 per share                                            9,680               9,602
                                                   --------             -------
                                                   --------             -------

Pro forma net loss per share                                  $ (0.29)            $ (0.63)
                                                              -------             -------
                                                              -------             -------

Shares used in computing pro forma 
 net loss per share                                             8,074               7,358
                                                              -------             -------
                                                              -------             -------
</TABLE>

                            See accompanying notes.

                                       4
<PAGE>

                          ONYX PHARMACEUTICALS, INC.


                       CONDENSED STATEMENTS OF CASH FLOW
                                 (In thousands)
                                  (unaudited)

<TABLE>
<CAPTION>
                                                              Six months ended
                                                                  June 30,
                                                           ---------------------
                                                              1997       1996
                                                           ---------   ---------
<S>                                                        <C>         <C>
CASH FLOWS FROM OPERATING ACTIVITIES:

Net loss                                                   $ (6,251)   $ (4,660)
Adjustments to reconcile net loss to net cash used 
  in operating activities:
  Depreciation and amortization                                 865         731
  Forgiveness of note receivable                                  -          25
  Amortization of deferred compensation                         110         137
  Changes in assets and liabilities:
    Other current assets                                         20          73
    Other assets                                                 11         (77)
    Accounts payable                                             93          63
    Accrued liabilities                                       1,069         457
    Accrued compensation                                         37          90
    Deferred revenue                                           (785)        (26)
    Deferred rent                                              (119)     (1,271)
                                                           ---------   ---------
Net cash used in operating activities                        (4,950)     (4,458)
                                                           ---------   ---------

CASH FLOWS FROM INVESTING ACTIVITIES:

Purchases of short-term investments                         (30,370)    (11,407)
Sales and maturities of short-term investments                4,071       8,704
Capital expenditures                                           (730)       (784)
Notes receivable from related parties                          (404)          -
Proceeds from sale of fixed assets                                -           -
                                                           ---------   ---------
Net cash used in investing activities                       (27,433)     (3,487)
                                                           ---------   ---------

CASH FLOWS FROM FINANCING ACTIVITIES:

Payments on long-term debt                                     (273)       (220)
Net proceeds from issuance of common stock                    3,550      35,311
Repurchase of common stock                                        -           -
                                                           ---------   ---------
Net cash provided by financing activities                     3,277      35,091
                                                           ---------   ---------

Net increase (decrease) in cash and cash equivalents        (29,106)     27,146

Cash and cash equivalents at beginning of the period         36,258       3,779
                                                           ---------   ---------

Cash and cash equivalents at end of the period             $  7,152    $ 30,925
                                                           ---------   ---------
                                                           ---------   ---------
</TABLE>


                            See accompanying notes.

                                       5
<PAGE>

                          ONYX PHARMACEUTICALS, INC.


                    NOTES TO CONDENSED FINANCIAL STATEMENTS
                                 JUNE 30, 1997
                                  (unaudited)

NOTE 1.  BASIS OF PRESENTATION

The accompanying unaudited condensed financial statements have been prepared 
in accordance with generally accepted accounting principles for interim 
financial information and with the instructions to Form 10-Q.  Accordingly, 
they do not include all of the information and footnotes required by 
generally accepted accounting principles for complete financial statements.  
In the opinion of management, all adjustments (consisting of normal recurring 
accruals) considered necessary for a fair presentation have been included.

Operating results for the three and six months ended June 30, 1997 are not 
necessarily indicative of the results that may be expected for the year 
ending December 31, 1997.  For further information, refer to the financial 
statements and footnotes thereto for the year ended December 31, 1996  
included in the ONYX Pharmaceuticals, Inc. (the "Company" or "ONYX") Annual 
Report on Form 10-K.

NOTE 2.  NET LOSS PER SHARE

Net loss per share is computed using the weighted average number of common 
shares outstanding.  Common equivalent shares are excluded from the 
computation as their effect is antidilutive, except that, pursuant to the 
Securities and Exchange Commission ("SEC") Staff Accounting Bulletins, common 
and common equivalent shares issued during the 12-month period prior to the 
filing of a registration statement in connection with the Company's initial 
public offering at prices below the public offering price of $12.00 have been 
included in the calculation as if they were outstanding for all periods 
presented through March 31, 1996 (using the treasury stock method for stock 
options at the estimated public offering price). 

Pro forma net loss per share for the three and six months ended June 30, 1996 
has been computed as described above and also gives effect to the conversion 
of convertible preferred shares not included above that automatically 
converted upon completion of the Company's initial public offering (using the 
if converted method) from original date of issuance.

Historical net loss per share for 1996 is as follows:

                                       Three months ended  Six months ended
                                          June 30, 1996      June 30, 1996
                                       ------------------  ----------------
    Net loss per share                      $  (0.41)         $  (1.29)
                                            ---------         ---------
                                            ---------         ---------
    Shares used in computing net
     loss per share                            5,814             3,608 
                                            ---------         ---------
                                            ---------         ---------

In February 1997, the Financial Accounting Standards Board issued Statement 
No. 128, Earnings per share, which is required to be adopted on December 31, 
1997. At that time, the Company will be required to change the method 
currently used to compute earnings per share and to restate all prior 
periods.  The impact on earnings per share for the three and six months ended 
June 30, 1997 and 1996 will not be material.

                                       6
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

                    NOTES TO CONDENSED FINANCIAL STATEMENTS
                                 JUNE 30, 1997
                                  (unaudited)

NOTE 3.  COLLABORATIVE AGREEMENTS

In accordance with the terms of the agreement dated May 4, 1995, 
Warner-Lambert Company ("Warner-Lambert") purchased 192,941 shares of common 
stock of the Company on May 2, 1997 at an aggregate purchase price of 
approximately $3,333,000.

NOTE  4.  MARKETABLE SECURITIES - AVAILABLE-FOR-SALE

The following is a summary of available-for-sale securities as of June 30, 
1997:

                                                  Available-for-sale
                                                      Securities
                                                 Estimated fair value
                                                    (in thousands)
                                                 --------------------
         Cash equivalents:
              U.S. corporate securities               $  2,490
              Money market funds                         4,662
                                                      --------
         Total cash equivalents:                         7,152
                                                      --------

         Short-term investments:
              U.S. corporate securities                 12,823
              Foreign corporate securities               9,896
              U.S. government securities                 2,037
                                                      --------
         Total short-term investments                   24,756
                                                      --------

         Total available-for-sale securities          $ 31,908
                                                      --------
                                                      --------

As of June 30, 1997, the difference between the fair value and the amortized 
cost of available-for-sale securities was insignificant.  The average 
portfolio duration is approximately five months, and the contractual maturity 
of each of the investments does not exceed two years.  Held at June 30, 1997, 
and excluded from short-term investments above, is $5,614,000 of certificates 
of deposits. 

NOTE 5.  LINE OF CREDIT

In March 1997, the Company entered into a $7 million line of credit 
arrangement with a bank.   The line bears interest at prime plus 1% and 
expires October 15, 1997.  The line is secured by certain assets of the 
Company and contains covenants related to maintaining debt-to-equity ratios, 
tangible net worth minimums, cash and investment balances, as well as a 
restriction on paying dividends or repurchasing stock.  As of June 30, 1997, 
no balance was outstanding on the line of credit.

                                       7
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

                    NOTES TO CONDENSED FINANCIAL STATEMENTS
                                 JUNE 30, 1997
                                  (unaudited)

NOTE 6.  SUBSEQUENT EVENT

On July 31, 1997, the Company signed a three-year research and development 
agreement with Warner-Lambert aimed at discovering new therapeutics to 
regulate inflammation and autoimmunity.  Terms of the agreement provide for 
receipt by the Company of an up-front licensing fee payable in three stages, 
as well as milestone payments and royalties on eventual product sales.  In 
return, Warner-Lambert receives exclusive worldwide marketing rights to 
products emerging from the collaboration.  Total payments to the Company 
prior to commercialization could total nearly $30 million.  Warner-Lambert 
has the right to terminate the agreement at its discretion on January 31, 
1999 upon written notice and provided that research payments to the Company 
are continued through July 31, 1999.  In addition, Warner-Lambert may 
terminate the research portion of the agreement, and associated research 
funding and milestone payments, at its discretion if a project director 
acceptable to Warner-Lambert has not been hired by ONYX prior to January 31, 
1998.

                                       8
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

                     MANAGEMENT'S DISCUSSION AND ANALYSIS 
                OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

EXCEPT FOR THE HISTORICAL INFORMATION CONTAINED HEREIN, THIS OVERVIEW AND THE 
FOLLOWING DISCUSSION CONTAIN FORWARD-LOOKING STATEMENTS THAT INVOLVE RISKS 
AND UNCERTAINTIES.  THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY FROM 
THOSE DISCUSSED HERE.  FACTORS THAT COULD CAUSE OR CONTRIBUTE TO SUCH 
DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE DISCUSSED IN THE ANNUAL 
REPORT ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 1996.

OVERVIEW

Since its inception, ONYX Pharmaceuticals, Inc. (the "Company" or "ONYX") has 
been engaged in the discovery and development of novel therapeutics based 
upon the genetics of human disease, with an emphasis on cancer.  Currently, 
the Company has five therapeutic discovery programs focused on the following 
cancer mutations:  p53, ras, cell cycle, BRCA1 and APC.

The Company intends to pursue its therapeutic discovery programs 
independently and in collaboration with pharmaceutical companies, and to 
collaborate with such companies on the development and commercialization of 
any products which may result from the Company's discovery programs.  The 
Company has entered into collaborative agreements with Bayer Corporation 
("Bayer") in the area of ras oncogenes, Warner-Lambert Company 
("Warner-Lambert") in the cell cycle area and Eli Lilly and Company ("Eli 
Lilly") on the function of the BRCA1 gene in breast cancer.

During the quarter ended June 30, 1997, the Company completed initial Phase I 
safety studies of ONYX-015 in patients with recurrent and refractory head and 
neck cancer.  ONYX-015 was found to be safe and well-tolerated, as well as 
biologically active.  Based on the results of this first Phase I study, the 
Company initiated a Phase II efficacy trial of ONYX-015 in the same patient 
population.  Three Phase I trials are also now underway, including pancreatic 
and ovarian cancers, and gastrointestinal cancers that have metastasized to 
the liver.  In addition, a lead compound was identified in the ras 
collaboration with Bayer Corporation.

On July 31, 1997, the Company signed a three-year research and development 
agreement with Warner-Lambert aimed at discovering new therapeutics to 
regulate inflammation and autoimmunity.  The Company believes that expanding 
into the area of inflammation is a natural step for the Company because some 
of the same biochemical pathways that lead to cancer also play an important 
role in the development of inflammatory disorders.  Terms of the agreement 
provide for receipt by the Company of an up-front licensing fee payable in 
three stages, as well as milestone payments and royalties on eventual product 
sales.  In return, Warner-Lambert receives exclusive worldwide marketing 
rights to products emerging from the collaboration.  Total payments to the 
Company prior to commercialization could total nearly $30,000,000.  
Warner-Lambert has the right to terminate the agreement at its discretion on 
January 31, 1999 upon written notice and provided that research payments to 
the Company are continued through July 31, 1999.  In addition, Warner-Lambert 
may terminate the research portion of the agreement, and associated research 
funding and milestone payments, at its discretion if a project director 
acceptable to Warner-Lambert has not been hired by ONYX prior to January 31, 
1998.

The Company has not been profitable since inception and expects to incur 
substantial and increasing losses for the foreseeable future, primarily due 
to the expansion of its research and development programs, including clinical 
trials in the p53 program.  The Company expects that losses will fluctuate 
from quarter to quarter and that such fluctuations may be substantial.  As of 
June 30, 1997, the Company's accumulated deficit was approximately $35,800,000.

The Company's business is subject to significant risks, including the risks 
inherent in its research and development efforts, uncertainties associated 
with obtaining and enforcing patents, the lengthy and expensive regulatory 
approval process and competition from other products.  The Company does not 
expect to generate revenues from the sale of proposed products in the 
foreseeable future.

                                       9
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

RESULTS OF OPERATIONS

THREE AND SIX MONTHS ENDED JUNE 30, 1997 AND 1996.

REVENUES

The Company's revenues increased 13% to $2,148,000 and 11% to $4,300,000 for 
the three and six months ended June 30, 1997, respectively, as compared to 
the same periods in 1996.  Revenues for the 1996 periods were $1,900,000 and 
$3,874,000, respectively.  Revenues for the three and six months ended June 
30, 1997 and 1996 were attributable to amounts earned for research performed 
under the Company's collaborations with Bayer, Warner-Lambert and Eli Lilly.  
The increase in revenues for the three and six months ended June 30, 1997 is 
primarily due to an expanded agreement with Eli Lilly which increased the 
funding levels under the agreement as compared to the funding levels in 1996.

RESEARCH AND DEVELOPMENT EXPENSES

Research and development expenses increased 44% to $5,103,000 and 27% to 
$8,980,000 for the three and six months ended June 30, 1997, respectively, as 
compared to the same periods in 1996.  The increase was primarily due to 
additional clinical costs associated with current and planned Phase I and 
Phase II clinical trials of ONYX-015, the lead product in the Company's p53 
program. The Company expects that research and development expenses will 
continue to grow significantly during future periods due to the hiring of 
personnel and the expansion of ONYX-015 clinical studies.

GENERAL AND ADMINISTRATIVE EXPENSES

General and administrative expenses increased 25% to $1,327,000 and 36% to 
$2,593,000 for the three and six months ended June 30, 1997, respectively, as 
compared to the same periods in 1996.  The increase was primarily due to 
increased administrative staffing, additional costs incurred in connection 
with corporate development activities and higher expenses associated with the 
Company's reporting and other requirements associated with operating as a 
publicly held company.  General and administrative expenses are expected to 
increase to support the Company's research and development efforts.

NET INTEREST INCOME

The Company had net interest income of $524,000 and $1,022,000 for the three 
and six months ended June 30, 1997 and 1996, respectively, as compared with 
$332,000 and $462,000 for the same periods in 1996.  The increase in net 
interest income reflects the Company's higher average balance of cash, cash 
equivalents and short-term investments resulting primarily from its initial 
public offering of common stock in May 1996.

LIQUIDITY AND CAPITAL RESOURCES

Since inception, the Company's cash expenditures have substantially exceeded 
its revenues.  The Company has relied primarily on the proceeds from the sale 
of equity securities and revenue from collaborative research and development 
agreements to fund its operations.

The Company's cash, cash equivalents and short-term investments were 
$37,522,000 at June 30, 1997, compared with $40,329,000 at December 31, 1996. 
Increasing levels of clinical research and product development associated 
with ONYX-015, the lead product in the p53 Program, and the higher levels of 
general and administrative expenses resulted in approximately $4,950,000 of 
cash used in operations for the six months ended June 30, 1997.  This cash 
decline was partially offset by Warner-Lambert's $3,333,000 purchase of 
192,941 shares of common stock in May 1997.  The Company expects cash used in 
operations will continue to increase as additional clinical trials for 
ONYX-015 commence.

                                       10
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

Total capital expenditures for equipment and leasehold improvements for the 
six months ended June 30, 1997 were $730,000.  The Company expects to make 
expenditures of approximately $1,900,000 for the remainder of 1997 for 
capital equipment and improvements to its existing facility.

The Company anticipates that its existing capital resources and interest 
thereon, and anticipated revenues from its existing collaborations will be 
sufficient to fund its current and planned operations through the end of 
1998. There can be no assurance, however, that changes in the Company's 
operating expenses will not result in the expenditure of such resources 
before such time, and in any event, the Company will need to raise 
substantial additional capital to fund its operations in future periods.  As 
of June 30, 1997, the Company had $7,000,000 available through a line of 
credit which expires on October 15, 1997.

BUSINESS RISKS

The Company is at an early stage of development.  The development of the 
Company's technology and proposed products will require a commitment of 
substantial funds to conduct these costly and time-consuming activities.  All 
of the Company's potential products are in research or development and will 
require significant additional research and development efforts prior to any 
commercial use, including extensive preclinical and clinical testing as well 
as lengthy regulatory approval.  The development of new products is subject 
to a number of significant risks.  Potential products that appear to be 
promising at an early stage of development may not reach the market for a 
number of reasons.  Such risks include the possibilities that the potential 
products will be found ineffective or unduly toxic during clinical trials, 
fail to receive necessary regulatory approvals, be difficult to manufacture 
on a large scale, be uneconomical to market or be precluded from 
commercialization by proprietary rights of third parties.  

In addition, many of the Company's potential products are subject to 
development and licensing arrangements with the Company's collaborators.  
Therefore, the Company is dependent on the research and development efforts 
of these collaborators.  Moreover, the Company is entitled to only a portion 
of the revenues, if any, realized from the commercial sale of any of the 
potential products covered by the collaborations.  Should the Company or its 
collaborators fail to perform in accordance with the terms of any of their 
agreements or terminate such agreements without cause, any consequent loss of 
revenue under the agreements could have a material adverse effect on the 
Company's results of operations. 

There can be no assurance that the Company will be able to maintain existing 
collaborative agreements, negotiate collaborative arrangements in the future 
on acceptable terms, if at all, or that any such collaborative arrangements 
will be successful.  To the extent that the Company is not able to maintain 
or establish such arrangements, the Company would be required to undertake 
such activities at its own expense.

The proposed products under development by the Company have never been 
manufactured on a commercial scale, and there can be no assurance that such 
products can be manufactured at a cost or in quantities necessary to make 
them commercially viable.  The Company has no sales, marketing or 
distribution capability.  If any of its products subject to collaborative 
agreements are successfully developed, the Company must rely on its 
collaborators to market such products.  If the Company develops any products 
which are not subject to collaborative agreements, it must either rely on 
other large pharmaceutical companies to market such products or must develop 
a marketing and sales force with technical expertise and supporting 
distribution capability in order to market such products directly.  

The Company intends to seek additional funding through collaborative 
arrangements, public or private equity or debt financings, capital lease 
transactions or other financing sources that may be available.  However, 
there can be no assurance that additional financing will be available on 
acceptable terms or at all.  If additional funds are raised by issuing equity 
securities, substantial dilution to existing stockholders may result.  If 
adequate funds are not available, the Company may be required to delay, 
reduce the scope of, or eliminate one or more of its research or development 
programs or to obtain funds through collaborative arrangements with others 
that are on unfavorable terms or that may require the Company to relinquish 


                                       11
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

rights to certain of its technologies, product candidates or products that the 
Company would otherwise seek to develop itself.
 
The foregoing risks reflect the Company's early stage of development and the 
nature of its industry and proposed product.  Also inherent in the Company's 
stage of development is a range of additional risks, including competition, 
uncertainties regarding protection of patents and proprietary rights, 
government regulation and uncertainties regarding health care reform. 

                                       12
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

PART II:  OTHER INFORMATION
 
ITEM 2.  CHANGES IN SECURITIES
 
         On May 2, 1997, the Company sold 192,941 shares of Common Stock to 
         Warner-Lambert Company for an aggregate purchase price of 
         $3,333,000.  The sale of such shares to Warner-Lambert Company was 
         deemed to be exempt from registration under the Securities Act of 
         1933, as amended, pursuant to Rule 4(2) thereof, as a transaction 
         not involving a public offering.
 
ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
 
         (a)  The Annual Meeting of Stockholders of ONYX Pharmaceuticals, 
              Inc., a Delaware corporation ("ONYX") was held on May 22, 1997.
 
         (b)  Each of management's nominees to the Board of Directors was 
              elected to serve until the Company's annual meeting of 
              stockholders in 2000.  The nominees were:  Paul Goddard, Ph.D., 
              8,556,498 common shares for, 15,657 withheld; Randy Thurman, 
              8,556,398 common shares for and 15,757 withheld; and Wendell 
              Wierenga, Ph.D., 8,555,177 common shares for and 16,978 withheld.
 
         (c)  (i)  The other matter presented to the stockholders at the 
                   Annual Meeting was the ratification of selection of Ernst 
                   & Young LLP as independent auditors of ONYX for the fiscal 
                   year ending  December 31, 1997:  8,553,048 common shares 
                   for, 9,883 against, 9,224 abstain and 0 non-votes.
 
              (ii) ONYX also solicited the approval of the stockholders on 
                   the following matters:
 
                   A.   An increase of 600,000 shares to the aggregate number
                        of shares of Common Stock authorized for issuance under
                        the 1996 Equity Incentive Plan, as amended, and to add
                        provisions to such plan with respect to Section 162(m)
                        of the Internal Revenue Code of 1986, as amended:
 
                        5,934,740 common shares for, 697,630 against, 15,931
                        abstain and 1,923,854 non-votes
 
                   B.   An amendment to the 1996 Non-Employee Directors' Plan,
                        as amended, to allow non-employee directors who are
                        also consultants to receive option grants under the
                        plan:
 
                        8,031,352 common shares for, 357,805 against, 28,417
                        abstain and 154,581 non-votes

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

         a)  Exhibits

                Exhibit 11.1   Statement Regarding Computation of Net Loss 
                               Per Share

                Exhibit 27.1   Financial Data Schedule

         b)  Form 8-K

                No reports on Form 8-K were filed during the period covered 
                by this report.

                                       13
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                                       ONYX PHARMACEUTICALS, INC.



Date:  August 14, 1997                 By:  /s/ Hollings C. Renton
                                            -----------------------------------
                                            Hollings C. Renton
                                            President, Chief Executive Officer
                                            and Director (Principal Executive 
                                            Officer)




Date:  August 14, 1997                 By:  /s/ Douglas L. Blankenship
                                            -----------------------------------
                                            Douglas L. Blankenship
                                            Treasurer 
                                            (Principal Financial and Accounting
                                            Officer)

                                       14
<PAGE>

                          ONYX PHARMACEUTICALS, INC.

EXHIBIT INDEX

                                                              Sequentially
                                                                Numbered
Exhibit Number   Description of Exhibits                          Page
- --------------   -----------------------                      ------------
     11.1        Statement Regarding Computation of 
                  Net Loss per Share                                

     27.1        Financial Data Schedule                            


                                       15

<PAGE>

                          ONYX PHARMACEUTICALS, INC.

Exhibit 11.1

                      COMPUTATION OF NET LOSS PER SHARE 
                   (In thousands, except per share amounts)
                                 (unaudited)


<TABLE>
<CAPTION>
                                                    Three Months Ended     Six Months Ended
                                                         June 30,              June 30, 
                                                   --------------------  --------------------
                                                      1997       1996       1997      1996
                                                   ---------  ---------  ---------  ---------
<S>                                                <C>        <C>        <C>        <C>
NET LOSS:                                          $ (3,758)  $ (2,367)  $ (6,251)  $ (4,660)
                                                   ---------  ---------  ---------  ---------
                                                   ---------  ---------  ---------  ---------
Shares used in net loss per share computation:

Weighted average shares of common stock 
  outstanding:                                        9,680      5,814      9,602      3,395 

Shares related to Staff Accounting 
  Bulletins Nos. 55, 64 and 83                            -          -          -        213 
                                                   ---------  ---------  ---------  ---------
Shares used in net loss per share 
  computation:                                        9,680      5,814      9,602      3,608 
                                                   ---------  ---------  ---------  ---------
                                                   ---------  ---------  ---------  ---------
Net loss per share                                 $  (0.39)  $  (0.41)  $  (0.65)  $  (1.29)
                                                   ---------  ---------  ---------  ---------
                                                   ---------  ---------  ---------  ---------

CALCULATION OF SHARES OUTSTANDING FOR 
COMPUTING PRO FORMA NET LOSS PER SHARE:

Shares used in computing historical net 
  loss per share (from above):                                   5,814                 3,608

Adjusted to reflect the effect of the assumed 
  conversion of convertible preferred stock from 
  the date of issuance:                                          2,260                 3,750
                                                              ---------             ---------

Shares used in computing pro forma net loss 
  per share:                                                     8,074                 7,358
                                                              ---------             ---------
                                                              ---------             ---------

Pro forma net loss per share                                  $  (0.29)             $  (0.63)
                                                              ---------             ---------
                                                              ---------             ---------
</TABLE>

    

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-START>                             JAN-01-1997
<PERIOD-END>                               JUN-30-1997
<CASH>                                           7,152
<SECURITIES>                                    30,370
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                38,140
<PP&E>                                           9,285
<DEPRECIATION>                                 (5,224)
<TOTAL-ASSETS>                                  43,210
<CURRENT-LIABILITIES>                            4,724
<BONDS>                                            270
                                0
                                          0
<COMMON>                                            10
<OTHER-SE>                                      38,322
<TOTAL-LIABILITY-AND-EQUITY>                    43,210
<SALES>                                              0
<TOTAL-REVENUES>                                 4,300
<CGS>                                                0
<TOTAL-COSTS>                                   11,573 
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                  34
<INCOME-PRETAX>                                (6,251)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (6,251)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (6,251)
<EPS-PRIMARY>                                   (0.65)
<EPS-DILUTED>                                   (0.65)
        

</TABLE>


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