COLLAGENEX PHARMACEUTICALS INC
DEFR14A, 1998-04-03
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                  Exchange Act of 1934 (Amendment No.     )

  Filed by the Registrant   |X|
  Filed by a Party other than the Registrant   | |

  Check the appropriate box:
  | |  Preliminary Proxy Statement
                                       | |  Confidential, for Use of the
                                            Commission Only (as permitted by
                                            Rule 14a-6(e)(2))
  |X|  Definitive Proxy Statement
  | |  Definitive Additional Materials
  | |  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                        CollaGenex Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)

- --------------------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate box):
  |X|  No fee required.
  | |  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

  (1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
  (2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
  (3)  Per unit price or other underlying value of transaction computed pursuant
to  Exchange  Act Rule 0-11 (set  forth the  amount on which the  filing  fee is
calculated and state how it was determined):

- --------------------------------------------------------------------------------
  (4)  Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------
  (5)  Total fee paid:

- --------------------------------------------------------------------------------
  | |  Fee paid previously with preliminary materials.

- --------------------------------------------------------------------------------
  | | Check  box if  any  part of  the fee is offset as provided by Exchange Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

  (1)  Amount Previously Paid:

- --------------------------------------------------------------------------------
  (2)  Form, Schedule or Registration Statement no.:

- --------------------------------------------------------------------------------
  (3)  Filing Party:

- --------------------------------------------------------------------------------
  (4)  Date Filed:

- --------------------------------------------------------------------------------


<PAGE>

                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 South State Street
                                Newtown, PA 18940





                                                                   April 8, 1998

To Our Stockholders:

        You  are  cordially  invited  to  attend  the  1998  Annual  Meeting  of
Stockholders of CollaGenex  Pharmaceuticals,  Inc. at 8:30 A.M.,  local time, on
Monday,  May 11, 1998, at the Marriott Hotel, 1201 Market Street,  Philadelphia,
Pennsylvania.

        The  Notice  of  Meeting  and Proxy  Statement  on the  following  pages
describe the matters to be presented at the meeting.

        It is  important  that your  shares be  represented  at this  meeting to
assure the presence of a quorum.  Whether or not you plan to attend the meeting,
we hope  that you will  have your  stock  represented  by  signing,  dating  and
returning your proxy in the enclosed envelope,  as soon as possible.  Your stock
will be voted in accordance with the instructions you have given in your proxy.

        Thank you for your continued support.


                                          Sincerely,



                                          Brian M. Gallagher, Ph.D.
                                          President and
                                             Chief Executive Officer


<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 South State Street
                                Newtown, PA 18940


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 11, 1998

        The  Annual  Meeting  of  Stockholders  (the  "Meeting")  of  COLLAGENEX
PHARMACEUTICALS,  INC., a Delaware corporation (the "Company"),  will be held at
the Marriott Hotel, 1201 Market Street, Philadelphia,  Pennsylvania,  on Monday,
May 11, 1998, at 8:30 A.M., local time, for the following purposes:

(1)     To elect  eight  directors  to serve  until the next  Annual  Meeting of
        Stockholders and until their respective  successors shall have been duly
        elected and qualified;

(2)     To ratify  the  appointment  of KPMG  Peat  Marwick  LLP as  independent
        auditors for the year ending December 31, 1998; and

(3)     To transact such other  business as may properly come before the Meeting
        or any adjournment or adjournments thereof.

        Holders of Common  Stock of record at the close of business on March 27,
1998 are entitled to notice of and to vote at the Meeting, or any adjournment or
adjournments  thereof.  A complete list of such stockholders will be open to the
examination of any stockholder at the Company's  principal  executive offices at
301 South State Street, Newtown, PA 18940 and at the Marriott Hotel, 1201 Market
Street, Philadelphia, Pennsylvania for a period of 10 days prior to the Meeting.
The Meeting may be  adjourned  from time to time  without  notice  other than by
announcement at the Meeting.

        IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED REGARDLESS OF THE NUMBER
OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE THE COMPANY THE EXPENSE OF FURTHER SOLICITATION. EACH PROXY GRANTED MAY
BE REVOKED BY THE  STOCKHOLDER  APPOINTING  SUCH PROXY AT ANY TIME  BEFORE IT IS
VOTED.  IF YOU  RECEIVE  MORE  THAN ONE  PROXY  CARD  BECAUSE  YOUR  SHARES  ARE
REGISTERED  IN  DIFFERENT  NAMES OR  ADDRESSES,  EACH SUCH PROXY CARD  SHOULD BE
SIGNED AND RETURNED TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.

                                          By Order of the Board of Directors





                                          Nancy C. Broadbent
                                            Secretary

Newtown, Pennsylvania
April 8, 1998

        The Company's 1997 Annual Report accompanies the Proxy Statement.


<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 South State Street
                                Newtown, PA 18940


- --------------------------------------------------------------------------------
                                 PROXY STATEMENT
- --------------------------------------------------------------------------------


        This Proxy Statement is furnished in connection with the solicitation by
the Board of Directors of CollaGenex  Pharmaceuticals,  Inc. (the  "Company") of
proxies to be voted at the Annual Meeting of  Stockholders  of the Company to be
held on Monday,  May 11, 1998 (the "Meeting") at the Marriott Hotel, 1201 Market
Street,  Philadelphia,  Pennsylvania  at  8:30  A.M.,  local  time,  and  at any
adjournment or adjournments thereof. Holders of record of Common Stock, $.01 par
value ("Common  Stock"),  as of the close of business on March 27, 1998, will be
entitled  to  notice  of and to  vote at the  Meeting  and  any  adjournment  or
adjournments  thereof.  As of that date,  there were 8,569,454  shares of Common
Stock issued and outstanding and entitled to vote. Each share of Common Stock is
entitled to one vote on any matter presented at the Meeting. The number of votes
entitled to be cast at the Meeting is 8,569,454.

        If proxies in the accompanying  form are properly executed and returned,
the Common  Stock  represented  thereby  will be voted in the  manner  specified
therein. If not otherwise specified, the Common Stock represented by the proxies
will be  voted  (i) FOR the  election  of the  eight  nominees  named  below  as
directors, (ii) FOR the ratification of the appointment of KPMG Peat Marwick LLP
as independent  auditors for the year ending  December 31, 1998 and (iii) in the
discretion  of the persons  named in the  enclosed  form of proxy,  on any other
proposals  which may  properly  come  before the Meeting or any  adjournment  or
adjournments thereof. Any Stockholder who has submitted a proxy may revoke it at
any time before it is voted, by written notice  addressed to and received by the
Secretary of the Company,  by submitting a duly  executed  proxy bearing a later
date or by electing to vote in person at the Meeting.  The mere  presence at the
Meeting  of the  person  appointing  a  proxy  does  not,  however,  revoke  the
appointment.

        The presence, in person or by proxy, of holders of Common Stock having a
majority  of the votes  entitled to be cast at the Meeting  shall  constitute  a
quorum.  The  affirmative  vote by the holders of a  plurality  of the shares of
Common  Stock  represented  at the  Meeting  is  required  for the  election  of
directors,  provided  a quorum is  present  in person or by proxy.  All  actions
proposed  herein  other than the  election  of  directors  may be taken upon the
affirmative  vote of  Stockholders  possessing  a majority  of the voting  power
represented at the Meeting, provided a quorum is present in person or by proxy.

        Abstentions  are  included  in the  shares  present at the  Meeting  for
purposes of determining  whether a quorum is present,  and are counted as a vote
against for  purposes of  determining  whether a proposal  is  approved.  Broker
non-votes  (when shares are  represented at the Meeting by a proxy  specifically
conferring only limited authority to vote on certain matters and no authority to
vote on other matters) are included in the determination of the number of shares
represented  at the Meeting  for  purposes  of  determining  whether a quorum is
present but are not counted for purposes of  determining  whether a proposal has
been approved and thus have no effect on the outcome.

        This Proxy  Statement,  together  with the related  proxy card, is being
mailed to the  Stockholders of the Company on or about April 8, 1998. The Annual
Report to  Stockholders  of the Company for the year ended  December  31,  1997,
including financial  statements (the "Annual Report"),  is being mailed together
with this Proxy Statement to all Stockholders of record as of March 27, 1998. In
addition, the Company has provided brokers,  dealers, banks, voting trustees and
their nominees,  at the Company's expense,  with additional copies of the Annual
Report so that such record  holders  could supply such  materials to  beneficial
owners as of March 27, 1998.


<PAGE>


                              ELECTION OF DIRECTORS
                              ---------------------

        At the Meeting,  eight  directors are to be elected  (which number shall
constitute  the entire  Board of  Directors of the Company) to hold office until
the next Annual Meeting of Stockholders  and until their  successors  shall have
been elected and qualified.

        It is the  intention of the persons  named in the enclosed form of proxy
to vote the stock represented thereby,  unless otherwise specified in the proxy,
for the election as directors of the persons whose names and biographies  appear
below.  All of the  persons  whose  names and  biographies  appear  below are at
present directors of the Company. In the event any of the nominees should become
unavailable or unable to serve as a director,  it is intended that votes will be
cast for a substitute nominee designated by the Board of Directors. The Board of
Directors  has no reason to believe  that the  nominees  named will be unable to
serve if elected.  Each of the  nominees  has  consented  to being named in this
Proxy Statement and to serve if elected.

        The current  Board of  Directors  and nominees for election to the Board
are as follows:

                                           Served as a         Positions with
Name                               Age    Director Since        the Company
- ----                               ---    --------------       --------------

Helmer P.K. Agersborg, Ph.D....    69          1992           Chairman of the
                                                              Board

Brian M. Gallagher, Ph.D.......    50          1994           President, Chief
                                                              Executive Officer
                                                              and Director

Peter R. Barnett, D.M.D........    46          1997           Director

Robert J. Easton...............    53          1993           Director

James E. Daverman..............    48          1995           Director

Stephen W. Ritterbush, Ph.D....    51          1992           Director

Pieter J. Schiller.............    60          1995           Director

Terence E. Winters, Ph.D.......    55          1992           Director

        The principal occupations and business experience, for at least the past
five years, of each nominee are as follows:

        DR.  AGERSBORG  has been  Chairman of the  Company's  Board of Directors
since March 1992 and served as its Chief  Executive  Officer and President until
March 1994. Dr.  Agersborg also serves as President and Chief Executive  Officer
of Afferon  Corporation and Maret  Corporation,  having joined such companies in
September 1992 and September 1994,  respectively.  Dr. Agersborg has also served
as director of Lidak  Pharmaceutical  since October 1992. Each of such companies
engages in  pharmaceutical  development.  From May 1987 until his  retirement in
June 1990, Dr. Agersborg was the President of Wyeth-Ayerst  Research Division of
American Home Products Corporation. Prior to that, and beginning in 1975, he was
a Vice  President,  and  then  an  Executive  Vice  President,  of  Wyeth-Ayerst
Laboratories Research Division.

        DR.  GALLAGHER  joined the Company in April 1994 as President  and Chief
Executive  Officer and was elected to the Board of Directors  in November  1994.
From 1988 until joining the Company, Dr. Gallagher was employed by Bristol-Myers
Squibb  Company  ("BMS") and its  predecessor,  Squibb  Corporation,  in various
executive positions including strategic planning, worldwide product and business
development and marketing.  From 1991 until joining the Company,  Dr.  Gallagher
was Vice  President  and  General  Manager  of Squibb  Diagnostics,  the in vivo
imaging  pharmaceutical  division.  Prior to that, Dr.  Gallagher served for ten
years with E.I. DuPont de Nemours & Co. in a variety of pharmaceutical research,
development, marketing and business management positions.


                                      -2-
<PAGE>


        DR.  BARNETT has been a director of the Company since  February 1997. He
is Senior Vice  President  and Chief  Operating  Officer of United  Dental Care,
Inc., a managed dental benefits firm, where he has served in such capacity since
January  1995.  From  August 1994 to January  1995,  Dr.  Barnett was  Executive
Director of Prudential  DMO, and from March 1993 to August 1994, he served as an
independent  consultant  in the managed  care field.  From January 1985 to March
1993, Dr. Barnett was a Senior Vice President with Pearle Vision, Inc.

        MR. EASTON has been a director of the Company since November 1993. He is
Managing Director of The Wilkerson Group, an IBM Company and a major health care
consulting  firm, where he has served in such capacity since 1986. Mr. Easton is
a former President of the Biomedical Marketing Association.

        MR.  DAVERMAN has been a director of the Company since November 1995. He
is a managing general partner of Marquette Venture Partners  ("MVP"),  a venture
capital  investment  company  which he  co-founded  in  1987.  Mr.  Daverman  is
President  of  Marquette  Management  Partners,  LLC,  the  general  partner  of
Marquette  Venture  Partners,  L.P. and a general  partner of MG II,  L.P.,  the
general  partner of Marquette  Venture  Partners II, L.P. and MVP II  Affiliates
Fund,  L.P. He is a member of the Board of Directors of the Technology  Advisory
Group of the Technology  Management  Office of the  University of Michigan.  Mr.
Daverman is a member of the Board of Directors of  Endocardial  Solutions,  Inc.
and numerous privately held companies.

        DR.  RITTERBUSH has been a director of the Company since its founding in
January 1992. He is managing  general  partner of Fairfax  Partners/The  Venture
Fund of Washington,  L.P., a venture capital fund,  which he co-founded in 1989.
Dr. Ritterbush serves as a director and is on the compensation  committee of the
Board of Directors of Apache Medical Systems, Inc.

        MR. SCHILLER has been a director of the Company since September 1995. He
joined  Advanced  Technology  Ventures  ("ATV"),  a  venture  capital  fund,  in
September 1986 and is currently a general  partner of various ATV funds. He is a
director of Anthra  Pharmaceuticals,  Inc., Endius,  Inc., Afferon  Corporation,
HealthShare Technology, Inc. and Novoste Corporation.

        DR.  WINTERS has been a director of the  Company  since its  founding in
January  1992. He is a general  partner of Columbine  Venture  Funds,  a venture
capital fund, of which he was a founder in 1983. He also serves as a director of
Afferon Corporation, Maret Corporation and Melanotan Corporation.

        All directors hold office until the next annual meeting of  stockholders
and until their successors  shall have been duly elected and qualified.  None of
the Company's  directors  are related to any other  director or to any executive
officer of the Company.

        THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE FOR EACH OF THE
NOMINEES FOR THE BOARD OF DIRECTORS.

Committees and Meetings of the Board
- ------------------------------------

        The Board of Directors has a Compensation  Committee (the  "Compensation
Committee"),  which approves  salaries and incentive  compensation for executive
officers of the Company and which  administers the Company's stock option plans,
and an Audit  Committee,  which  reviews  the results and scope of the audit and
other  services  provided  by  the  Company's   independent   accountants.   The
Compensation  Committee  currently  consists  of Robert J.  Easton,  Stephen  W.
Ritterbush,  Ph.D. and Terence E. Winters,  Ph.D. The Compensation Committee was
established  in March 1996 and held two  meetings in 1997.  The Audit  Committee
currently consists of James E. Daverman, Stephen W. Ritterbush, Ph.D. and Pieter
J.  Schiller.  The Audit  Committee was  established  in March 1996 and held one
meeting in 1997. There were four meetings of the Board of Directors during 1997.
Each incumbent  director  attended at least 75% of the aggregate of all meetings
of the  Board of  Directors  held  during  the  period  in which he  served as a
director  and the total  number of meetings  held by the  committee  on which he
served during the period, if applicable.


                                      -3-
<PAGE>


Compensation of Directors
- -------------------------

        Helmer  P.K.  Agersborg  is paid  $36,000  per year for his  services as
Chairman of the Board.  Peter R.  Barnett  receives  $1,500 per meeting for each
meeting of the Board of Directors attended. The Wilkerson Group, an IBM Company,
receives $1,500 per meeting for each meeting of the Board of Directors  attended
by Mr. Easton.  No other directors receive cash compensation for services on the
Board  of  Directors.  The  Company  provides  reimbursement  to  directors  for
reasonable  and necessary  expenses  incurred in connection  with  attendance at
meetings of the Board of Directors and other Company business.

        Prior to the effective  date of the Company's  initial  public  offering
(the "IPO"),  the Company granted options to certain  directors as follows:  (i)
Dr. Agersborg was granted options to purchase 60,625,  28,084, and 22,500 shares
of  Common  Stock  on March 1,  1992,  September  1,  1993  and  March 1,  1995,
respectively,  at exercise prices of $0.20, $0.20 and $0.335,  respectively.  Of
such  options,  an aggregate  of 88,709 have been  exercised  and the  remaining
options  vested to the extent of 7,500 shares on March 1, 1996,  7,500 shares on
March 1, 1997 and 7,500  shares on March 1, 1998;  (ii) Mr.  Easton was  granted
options to purchase  7,500 shares of Common Stock on each of January 1, 1994 and
October 1, 1995 at  exercise  prices of $0.20 and $1.20,  respectively.  Of such
options,  7,500 have been  exercised  and, of the  remaining  7,500,  5,000 have
vested  and 2,500 will vest on October  1,  1998;  and (iii) Dr.  Gallagher  was
granted  options to purchase 50,000 shares of Common Stock on each of October 1,
1995 and October  15, 1995 at exercise  prices of $1.20 per share and $0.335 per
share,  respectively.  As of April 1,  1998,  25,000 of the  options  granted on
October 1, 1995 had  vested,  and 49,167 of the  options  granted on October 15,
1995 had vested.

        On the effective  date of the Company's  IPO,  pursuant to the Company's
1996 Non-Employee  Director Stock Option Plan (the  "Non-Employee  Plan"),  each
non-employee  director of the Company,  then  consisting of Drs.  Ritterbush and
Winters and Messrs. Easton,  Daverman and Schiller, was automatically granted an
option to purchase 10,000 shares of Common Stock, at an exercise price per share
equal to $10.00.  On November  22,  1996,  the Board of Directors of the Company
adopted,  and on May 8, 1997 the  Stockholders  approved,  an  amendment  to the
Non-Employee Plan which,  among other things, (i) increased the number of shares
of Common Stock  underlying  the  automatic  option  grants to new  non-employee
directors  from  10,000 to 25,000  shares;  and (ii)  provided  for the grant of
options to purchase an additional  15,000 shares of Common Stock, at an exercise
price per share of $9.75,  to each of Drs.  Ritterbush  and  Winters and Messrs.
Easton, Daverman and Schiller. In February 1997, Dr. Barnett was granted options
to purchase  25,000  shares of Common  Stock at an  exercise  price of $9.00 per
share  under the  Non-Employee  Plan upon his  election  to the Board.  All such
options become exercisable in five equal annual installments commencing one year
after the date of grant  provided  that the optionee  then remains a director at
the  time  of  vesting  of  the  installments.  The  right  to  exercise  annual
installments   of  options   under  the   Non-Employee   Plan  will  be  reduced
proportionately based on the optionee's actual attendance at Directors' meetings
if the optionee fails to attend at least 75% of the Directors'  meetings held in
any calendar year. On February 7, 1997, Dr.  Gallagher was granted options under
the Company's 1996 Stock Plan (the "1996 Stock Plan") to purchase  50,000 shares
of Common Stock,  at an exercise  price of $9.00 per share.  Such options become
exercisable in five equal annual  installments  beginning  February 7, 1997. The
vesting on these options may accelerate if certain  conditions are met. Finally,
on April 4, 1997, Dr. Agersborg was granted options under the 1996 Stock Plan to
purchase  25,000  shares of Common  Stock,  at an  exercise  price of $12.75 per
share.  Such  options  become  exercisable  in five  equal  annual  installments
beginning on April 4, 1997.


                                      -4-
<PAGE>


                               EXECUTIVE OFFICERS
                               ------------------

        The following  table  identifies the current  executive  officers of the
Company:

                                       Capacities in              In Current
Name                           Age     Which Served             Position Since
- ----                           ---     ------------             --------------

Brian M. Gallagher, Ph.D...    50    President, Chief           April 1994
                                     Executive Officer and      (Director since
                                     Director                   November 1994)

Robert A. Ashley(1)........    40    Vice President,            September 1994
                                     Commercial Development

Nancy C. Broadbent(2)......    42    Chief Financial            March 1996
                                     Officer, Treasurer
                                     and Secretary

Douglas C. Gehrig(3).......    53    Vice President, Sales      June 1997

David P. Pfeiffer(4).......    35    Vice President,            June 1997
                                     Marketing
- ----------

(1)     Mr.  Ashley  joined the  Company in  September  1994 as Vice  President,
        Commercial  Development.  From 1989 until  joining the  Company,  he was
        employed  by BMS and its  predecessor,  Squibb  Corporation,  in various
        positions  including  product   development,   commercial  and  business
        development and, most recently, as Director,  Business Development where
        he was responsible for the worldwide  product and market  development of
        several new drugs.  From 1979 to 1989, Mr. Ashley held various positions
        at Amersham  International (UK) Ltd.,  including research,  development,
        manufacturing,  sales  and  marketing  positions,  as well as  worldwide
        product development and product launch positions.

(2)     Ms.  Broadbent  joined  the  Company  in March  1996 as Chief  Financial
        Officer,  Treasurer and  Secretary.  From October 1994 until joining the
        Company, Ms. Broadbent served as Senior Vice President,  Chief Financial
        Officer and director of Human  Genome  Sciences,  Inc., a  biotechnology
        company. From January 1993 to October 1994, she served as Vice President
        and Chief  Financial  Officer  of  Cangene,  Inc.,  a  biopharmaceutical
        company.  From January 1992 through  December 1992, Ms. Broadbent served
        as an  independent  financial  consultant.  From March 1990 to  December
        1991,  she was  employed by Baring  Brothers & Co.,  Inc.,  initially as
        Senior Vice President and then as Executive Director, Corporate Finance.
        Prior to that, Ms. Broadbent served for nine years in corporate  finance
        positions with Salomon Brothers, Inc. and PaineWebber Incorporated.

(3)     Mr.  Gehrig  joined the Company in June 1997 as Vice  President,  Sales.
        From  September  1991 until joining the Company,  he was employed by the
        Musculoskeletal Transplant Foundation,  most recently as Vice President,
        Hospital  Sales.  From January 1990 until September 1991, Mr. Gehrig was
        Director of Sales for the Consumer  Product  Division of Warner Lambert.
        Prior to that,  he served for 19 years in various  sales,  marketing and
        sales management positions with Johnson & Johnson.

(4)     Mr.  Pfeiffer  joined  the  Company  in June  1997  as  Vice  President,
        Marketing.  From September 1995 until June 1997, Mr.  Pfeiffer served as
        Director  of  Marketing,  Health  Management  Services,  for  SmithKline
        Beecham.  From  May 1994 to  September  1995,  Mr.  Pfeiffer  served  as
        Director,  Disease  Management  Services  of Stuart  Disease  Management
        Services.  From  October  1991 to May 1994 he was  employed  in  various
        product  management  positions with Zeneca  Pharmaceuticals  Group. From
        July 1988 to October  1991,  Mr.  Pfeiffer  held various  marketing  and
        product management positions with the Lederle  Laboratories  Division of
        American Cyanamid.


                                      -5-
<PAGE>


        None  of the  Company's  executive  officers  is  related  to any  other
executive officer or to any director of the Company.  Executive  officers of the
Company are elected  annually  by the Board of  Directors  and serve until their
successors are duly elected and qualified.

Section 16(a) Beneficial Ownership Reporting Compliance
- -------------------------------------------------------

        Section  16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange Act"), requires the Company's directors, officers and stockholders who
beneficially own more than 10% of any class of equity  securities of the Company
registered pursuant to Section 12 of the Exchange Act to file initial reports of
ownership  and reports of changes in  ownership  with  respect to the  Company's
equity securities with the Securities and Exchange  Commission (the "SEC").  All
reporting  persons are  required by SEC  regulation  to furnish the Company with
copies of all reports that such reporting  persons file with the SEC pursuant to
Section 16(a).

        Based  solely  on the  Company's  review  of the  copies  of such  forms
received  by the  Company  and upon  written  representations  of the  Company's
reporting  persons received by the Company,  Douglas C. Gehrig,  Vice President,
Sales,  and David P. Pfeiffer,  Vice President,  Marketing,  did not report on a
timely basis certain  transactions.  In particular,  Mr. Gehrig failed to timely
report on a Form 3 his election on June 16, 1997 as Vice President,  Sales.  Mr.
Gehrig filed such Form 3 with the Securities  and Exchange  Commission on August
11, 1997. Mr.  Pfeiffer failed to timely report on a Form 3 his election on June
9, 1997 as Vice  President,  Marketing.  Mr. Pfeiffer filed such Form 3 with the
Securities and Exchange Commission on August 11, 1997.


                                      -6-
<PAGE>


                             EXECUTIVE COMPENSATION
                             ----------------------

Summary of Compensation in Fiscal 1997, 1996 and 1995
- -----------------------------------------------------

        The  following  Summary   Compensation   Table  sets  forth  information
concerning  compensation for services in all capacities awarded to, earned by or
paid to each person who served as the Company's Chief  Executive  Officer at any
time during 1997 and each other executive officer of the Company whose aggregate
cash compensation exceeded $100,000 at the end of 1997 (collectively, the "Named
Executives") during the years ended December 31, 1995, 1996 and 1997.


                          SUMMARY COMPENSATION TABLE(1)
- --------------------------------------------------------------------------------
                                                                     Long-Term
                                                                    Compensation
                                               Annual Compensation    Awards
                                               -------------------  ----------
                                                                    Securities
                                                                    Underlying
      Name and Principal Position       Year   Salary      Bonus     Options
                                                 ($)        ($)        (#)
                  (a)                   (b)      (c)        (d)        (g)
- --------------------------------------  ----   -------     ------   ----------

Brian M. Gallagher, Ph.D(2) .........   1997   250,000     42,536      50,000
      President and Chief Executive     1996   225,000     50,000           0
      Officer                           1995   225,000     50,000     100,000

Robert A. Ashley ....................   1997   157,500     36,125      25,000
      Vice President, Commercial        1996   139,961     30,000           0
      Development                       1995   120,000     10,000      37,500

Nancy C. Broadbent(3) ...............   1997   173,250     36,380      25,000
      Chief Financial Officer,          1996   137,500     30,000      60,000
      Treasurer and Secretary           1995      --         --          --

- ----------

(1)     The costs of certain  benefits  are not  included  because  they did not
        exceed,  in the case of each Named  Executive,  the lesser of $50,000 or
        10% of the total annual salary and bonus reported in the above table.

(2)     In  November  1994,  Dr.  Gallagher  purchased  125,000  shares  of  the
        Company's  restricted  Common Stock at $0.335 per share. Such shares are
        subject to vesting and the Company's repurchase right and right of first
        refusal. Of such shares, 25,000 vested immediately, an additional 83,332
        shares vested as of April 1, 1998 and the  remaining  16,668 shares will
        vest in equal monthly  portions over the next eight months.  Pursuant to
        the Company's  repurchase  right,  the Company may repurchase any of Dr.
        Gallagher's unvested shares, at a purchase price of $0.335 per share, at
        the time of termination of his service.  Pursuant to the Company's right
        of first refusal, the Company may buy back Dr. Gallagher's vested shares
        at $0.335 per share,  if Dr.  Gallagher is terminated for cause,  and at
        the current  market value per share,  if he is terminated  for any other
        reason.  At December  31, 1997,  Dr.  Gallagher  held 102,083  shares of
        restricted Common Stock with a year-end value of $1,241,840 based on the
        value of the Common Stock as of such date  ($12.50 per share),  less the
        purchase price per share paid for such shares ($0.335 per share).

(3)     Ms.  Broadbent  joined  the  Company  in March  1996 as Chief  Financial
        Officer, Treasurer and Secretary.


                                      -7-
<PAGE>

Option Grants in 1997
- ---------------------

        The following table sets forth information  concerning individual grants
of stock options made  pursuant to the Company's  1996 Stock Plan during 1997 to
each  of  the  Named  Executives.  The  Company  has  never  granted  any  stock
appreciation rights.

<TABLE>
<CAPTION>

                                     OPTION GRANTS IN LAST FISCAL YEAR(1)
- -------------------------------------------------------------------------------------------------------------
                                         Individual Grants
- ------------------------------------------------------------------------------------
                                                                                         Potential Realizable
                                                                                               Value at
                                                                                         Assumed Annual Rates
                                  Number of     Percent of                                    of Stock
                                 Securities    Total Options                              Price Appreciation
                                 Underlying     Granted to     Exercise                      for Option
                                  Options      Employees in    or Base                        Term (4)
                                  Granted         Fiscal         Price    Expiration     -------------------
            Name                   (#)(2)         Year(3)       ($/Sh)      Date          5%($)      10%($)
             (a)                    (b)             (c)          (d)         (e)           (f)        (g)
- ------------------------------    ------       -------------   -------    ----------     -------    --------

<S>                               <C>              <C>         <C>         <C> <C>       <C>        <C>    
Brian M. Gallagher, Ph.D .....    50,000           15.4%       $ 9.00      2/6/07        283,003    717,184

Robert A. Ashley .............    25,000            7.7%       $ 9.00      2/6/07        141,501    358,592

Nancy C. Broadbent ...........    25,000            7.7%       $ 9.00      2/6/07        141,501    358,592

</TABLE>

- -----------

(1)     Mr.  Gehrig  was  granted  options  to  purchase  60,000  shares  of the
        Company's  Common Stock in July 1997 at an exercise price of $10.625 per
        share. Mr. Pfeiffer was granted options to purchase 60,000 shares of the
        Company's  Common Stock in July 1997 at an exercise price of $10.625 per
        share.

   
(2)     Such  options  were  granted  pursuant  to and in  accordance  with  the
        Company's  1996 Stock Plan. The 1996 Stock Plan was adopted by the Board
        of Directors  and approved by the  Stockholders  of the Company on March
        22, 1996 and March 29, 1996, respectively.  A total of 750,000 shares of
        Common  Stock  currently  are reserved  for  issuance  upon  exercise of
        options and/or stock purchase  rights granted under the 1996 Stock Plan.
        Those  eligible to receive stock option grants under the 1996 Stock Plan
        include  employees,  non-employee  directors and  consultants.  The 1996
        Stock  Plan is  administered  by the  Compensation  Committee,  which is
        comprised solely of outside directors.  Subject to the provisions of the
        1996  Stock  Plan,  the  administrator  of the 1996  Stock  Plan has the
        discretion  to determine  the  optionees  and/or  grantees,  the type of
        options to be granted (incentive stock options ("ISOs") or non-qualified
        stock  options  ("NQSOs")),  the  vesting  provisions,  the terms of the
        grants and such other related provisions as are consistent with the 1996
        Stock Plan.  The exercise  price of an ISO may not be less than the fair
        market  value per share of the Common  Stock on the date of grant or, in
        the  case  of an  optionee  who  beneficially  owns  10% or  more of the
        outstanding capital stock of the Company, not less than 110% of the fair
        market  value per share on the date of grant.  The  exercise  price of a
        NQSO may not be less than 85% of the fair  market value per share of the
        Common  Stock on the date of grant  or, in the case of an  optionee  who
        beneficially  owns 10% or more of the  outstanding  capital stock of the
        Company,  not less than 110% of the fair  market  value per share on the
        date of grant.  The purchase  price of shares  issued  pursuant to stock
        purchase  rights  may not be less than 50% of the fair  market  value of
        such shares as of the offer date of such rights.  The options  terminate
        not more  than ten  years  from the date of grant,  subject  to  earlier
        termination  on the  optionee's  death,  disability  or  termination  of
        employment  with the  Company,  but provide that the term of any options
        granted  to a holder  of more  than  10% of the  outstanding  shares  of
        capital stock may be
    

                                       -8-
<PAGE>


        no longer  than five  years.  Options are not  assignable  or  otherwise
        transferable except by will or the laws of descent and distribution.  In
        the  event of a merger  or  consolidation  of the  Company  with or into
        another  corporation  or the  sale  of all or  substantially  all of the
        Company's  assets in which the  successor  corporation  does not  assume
        outstanding options or issue equivalent options,  the Board of Directors
        is required to provide accelerated vesting of outstanding  options.  The
        1996 Stock Plan terminates on March 21, 2006.

(3)     Based on an aggregate of 323,750  options  granted to employees in 1997,
        including options granted to Named Executives.

(4)     Based on a grant date fair market value of $9.00 per share.

Aggregated Option Exercises in 1997
and Year End Option Values
- -----------------------------------

        The following table sets forth  information  concerning each exercise of
options  during 1997 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.

<TABLE>
<CAPTION>


                             AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                                    AND FISCAL YEAR END OPTION VALUES
- ---------------------------------------------------------------------------------------------------------
                                                                  Number of               Value of
                                                              Securities Underlying      Unexercised
                                                                 Unexercised             In-the-Money
                                                                 Options at              Options at
                                                                   Fiscal                  Fiscal
                                     Shares                       Year-End                Year-End
                                   Acquired on      Value           (#)                    ($) (1)
                                    Exercise      Realized       Exercisable/            Exercisable/
           Name                       (#)           ($)         Unexercisable            Unexercisable
            (a)                       (b)           (c)             (d)                      (e)
- ------------------------------    ----------     ---------    ---------------------   ------------------
<S>                                   <C>        <C>             <C>                  <C>
Brian M. Gallagher, Ph.D .....          --       $     --        71,667/78,333        $ 850,205/$498,046

Robert A. Ashley .............          --             --        28,125/53,125        $ 325,922/$413,422

Nancy C. Broadbent ...........        24,000       273,000           0/61,000         $       0/$465,500

</TABLE>


- -------------

(1)     Based on a year end fair market value of the underlying securities equal
        to $12.50, less the exercise price payable for such shares.


                                      -9-
<PAGE>


Employment Contracts, Termination of Employment and
Change-in-Control Arrangements
- ---------------------------------------------------

        The Company has  executed  indemnification  agreements  with each of its
executive  officers  and  directors  pursuant to which the Company has agreed to
indemnify such parties to the full extent  permitted by law,  subject to certain
exceptions,  if such party becomes  subject to an action because such party is a
director,  officer, employee, agent or fiduciary of the Company. In general, the
Company's employees are covered by confidentiality agreements.

        In addition,  each of Dr.  Gallagher,  Ms. Broadbent and Mr. Ashley have
agreed  that  during the term of his or her  employment  and for a period of two
years thereafter,  such person will not directly or indirectly  provide services
to  or  for  any  business  engaged  in  research   regarding  the  development,
manufacture,  testing,  marketing or sale of  collagenase  inhibiting  drugs for
application in periodontal  disease or any other application  which,  during the
period of such person's  employment  with the Company,  is either marketed or in
advanced clinical development by the Company.

Compensation Committee Interlocks and Insider Participation
- -----------------------------------------------------------

        The  Compensation  Committee  consists of, and during 1997 consisted of,
Robert J. Easton,  Stephen W.  Ritterbush,  Ph.D. and Terence E. Winters,  Ph.D.
There are no, and during 1997 there were no, Compensation Committee Interlocks.

        As of  April 1,  1998,  each of  Fairfax  Partners/The  Venture  Fund of
Washington,  L.P., with which Dr. Ritterbush is affiliated and Columbine Venture
Fund II, L.P.,  with which Dr. Winters is  affiliated,  held 446,517 and 969,328
shares, respectively, of the Company's Common Stock which were previously issued
upon conversion of certain shares of the Company's  Series A, Series B or Series
C Redeemable  Preferred Stock  previously held by such entities.  Such shares of
Common Stock are entitled to certain  registration  rights and certain rights to
participate in certain future offerings undertaken by the Company.

        In September  1995,  the Company and the then  holders of the  Company's
Series A,  Series B and  Series C  Redeemable  Preferred  Stock  entered  into a
Registration  Rights  Agreement (the "Rights  Agreement")  pursuant to which the
Company has granted certain  registration rights to such Stockholders.  Pursuant
to the Rights  Agreement,  at any time beginning six months after June 20, 1996,
the effective  date of the Company's  IPO, the holders of at least a majority of
the Common Stock issued upon the conversion of the Series A, Series B and Series
C Redeemable  Preferred  Stock (the  "Registrable  Securities")  have the right,
subject to certain  restrictions set forth in the Rights  Agreement,  to require
that the Company register the Registrable  Securities  requested by such holders
at the Company's  expense (on no more than two  occasions) on either a Form S-1,
Form S-2 or Form S-3 Registration Statement under the Securities Act of 1933, as
amended  (the  "Securities  Act").  The  Company is not,  however,  required  to
register any Registrable Securities unless such shares represent at least 10% of
the Company's  outstanding  shares of Common Stock, or, if less than 10%, if the
anticipated aggregate offering price exceeds $1,000,000.

        The  holders  of  Registrable  Securities  also  have  the  right  to an
unlimited  number of  registrations  on Form S-3 under the  Securities  Act. The
Company is not,  however,  required  to effect  such a  registration  unless the
requesting holders reasonably  anticipate having an aggregate  disposition price
of at least $500,000.

        Also  pursuant  to the  Rights  Agreement,  if, at any time  during  the
seven-year  period  commencing on the effective  date of the Company's  IPO, the
Company  proposes to register any of its Common Stock under the  Securities  Act
for sale to the public, the holders of the Registrable Securities have unlimited
piggyback  registration  rights at the  Company's  expense,  subject  to certain
restrictions set forth in the Rights Agreement.

        Also in  September  1995,  the  Company  granted to the then  holders of
Series A, Series B and Series C Redeemable  Preferred  Stock  certain  rights to
participate in certain future offerings  undertaken by the Company.  Such rights
to participate require that, with certain exceptions including,  but not limited
to, an underwritten  public  offering,  any time the Company  proposes to issue,
sell or exchange,  or reserve therefor,  any securities,  the Company must first
offer to sell to each of the  pre-conversion  holders of Series A,  Series B and
Series C Redeemable


                                      -10-
<PAGE>


Preferred  Stock their  respective pro rata share of such  securities at a price
and on terms  identical to the price and terms of the securities  proposed to be
issued, sold or exchanged in the applicable offering.


Performance Graph
- -----------------

        The following graph compares the cumulative total stockholder  return on
the  Company's  Common  Stock  with the  cumulative  total  return on the Nasdaq
Composite Index and the Nasdaq  Pharmaceutical Index  (capitalization  weighted)
for the  period  beginning  on the date on which  the  Securities  and  Exchange
Commission  declared  effective the Company's  Form 8-A  Registration  Statement
pursuant  to  Section 12 of the  Exchange  Act and ending on the last day of the
Company's last completed fiscal year.

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)
                 ----------------------------------------------

              Among the Company, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)



                               Base Period   December      June     December
      Company/Index Name        June 1996      1996        1997       1997
- ----------------------------   -----------   --------    --------   --------
CGPI........................      $100       $  89.04    $ 131.51   $ 136.99
NASDAQ......................       100         110.46      123.67     135.61
NASDAQ PHAR.................       100          98.41      101.11     101.87

- -------------

(1)     Graph  assumes $100  invested on June 20, 1996 in the  Company's  Common
        Stock,  the Nasdaq Composite Index and the Nasdaq  Pharmaceutical  Index
        (capitalization weighted).

(2) Total return assumes reinvestment of dividends.

(3) Year ended December 31.


                                      -11-
<PAGE>


Compensation Committee Report on Executive Compensation
- -------------------------------------------------------

        The Compensation Committee has furnished the following report:

        The Compensation Committee is composed of three non-employee  directors.
The  Compensation  Committee  recommends,  and the Board  approves,  all matters
relating to executive compensation, including setting and administering policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The  Compensation  Committee meets twice annually to set performance  objectives
for the Chief Executive Officer ("CEO") and to determine the annual compensation
of the CEO and other senior  executives  of the Company.  The CEO is not present
during the discussion of his compensation.

EXECUTIVE COMPENSATION POLICY

        The goal of the  Company's  executive  compensation  policy is to ensure
that an appropriate  relationship exists between executive  compensation and the
creation of stockholder  value,  while at the same time attracting and retaining
qualified  senior  management.  Since its  inception  in 1992,  the  Company has
operated as a "virtual"  pharmaceutical  company  with a small  number of highly
experienced  senior executives  determining and executing the Company's strategy
while contracting out pharmaceutical development activities to clinical research
and other  third party  organizations.  In order to attract  highly  experienced
executives, the Company's compensation packages for senior executives are highly
competitive  with  those paid to  executives  of other  emerging  pharmaceutical
companies.

COMPENSATION MIX

        The Company's  executive  compensation  packages generally include three
components: base salary, a discretionary annual cash bonus and stock options.

BASE SALARY

        The  Compensation  Committee  seeks to establish  base salaries for each
position  and  level of  responsibility  which  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

DISCRETIONARY CASH BONUS

        The Compensation  Committee believes that discretionary cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

STOCK OPTIONS

        Stock option grants under the Company's  stock option plans are designed
to align the long term interests of the Company's  executives  with those of its
stockholders  by rewarding  executives for  increasing  stockholder  value.  All
executive  officers are awarded option grants upon joining the Company which are
competitive  with those at  comparable  emerging  pharmaceutical  companies.  In
addition,  the  Compensation  Committee may award additional stock option grants
annually.  When granting stock options, the Compensation Committee considers the
recommendation of the CEO and the relative performance and contributions of each
officer  compared  to that of other  officers  within the Company  with  similar
levels of responsibility.

COMPENSATION OF THE CHIEF EXECUTIVE OFFICER

        In establishing Dr. Gallagher's  compensation  package, the Compensation
Committee  seeks  to  maintain  a level of total  current  compensation  that is
competitive with that paid to CEOs of other comparable  emerging  pharmaceutical
companies.  In addition,  in order to align Dr.  Gallagher's  interests with the
interests of the 


                                      -12-
<PAGE>


Company's   stockholders,   the  Compensation   Committee  attempts  to  make  a
substantial  portion  of the value of his total  compensation  dependent  on the
appreciation of the Company's stock price.

        Dr.  Gallagher's  performance is evaluated  annually by the Compensation
Committee  against a stated  list of  short,  medium  and long  term  objectives
developed  by the  Compensation  Committee  at the  beginning  of each  year and
approved by the Board.  Based on his achievements  relating to these objectives,
the Compensation Committee  recommended,  and the board approved, a bonus to Dr.
Gallagher  of $50,000 for 1997,  which is paid in 1998,  and an increase in base
salary from $250,000 to $262,500 effective January 1, 1998.

        Section 162(m) of the Internal Revenue Code disallows the  deductibility
by the Company of any compensation over $1 million paid to the CEO or any of the
other four most highly  compensated  executives,  unless  certain  criteria  are
satisfied.  The Company's CEO and the other named  executives  have not received
annual  compensation  over $1 million,  and the Company has not determined  what
measures, if any, it should take to comply with Section 162.

                                                 Compensation Committee Members:

                                                 Robert J. Easton
                                                 Stephen W. Ritterbush, Ph.D.
                                                 Terence E. Winters, Ph.D.


                                      -13-
<PAGE>


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
         --------------------------------------------------------------

        There are, as of February 15, 1998,  approximately  86 holders of record
and 1,700 beneficial  holders of the Company's Common Stock. The following table
sets forth  certain  information,  as of  February  15,  1998,  with  respect to
holdings of the  Company's  Common Stock by (i) each person known by the Company
to be the  beneficial  owner of more  than 5% of the  total  number of shares of
Common Stock  outstanding as of such date, (ii) each of the Company's  directors
(which includes all nominees) and Named Executives,  and (iii) all directors and
officers as a group.

<TABLE>
<CAPTION>


                                              Amount and Nature of       Percent
Name and Address of Beneficial Owner(1)       Beneficial Ownership(1)   of Class(2)
- ---------------------------------------       -----------------------   -----------
(i)  Certain Beneficial Owners:
<S>                                                <C>                      <C> 
Columbine Venture Fund II, L.P.
6155 N. Scottsdale Road, Suite 100
Scottsdale, Arizona 85250 .................        969,328                 11.3%

Marquette Venture Partners II, L.P.
  and MVP II Affiliates Fund, L.P.
520 Lake Cook Road, Suite 450
Deerfield, Illinois 60015 .................        916,313(3)              10.7

Zesiger Capital Group LLC
320 Park Avenue, 30th Floor
New York, New York 10022 ..................        652,700                  7.6

Delphi Ventures III, L.P. and
  Delphi  Investments III, L.P.
3000 Sand Hill Road
Building 1, Suite 135
Menlo Park, California 94025 ..............        625,000(4)               7.3

Fairfax Partners/The Venture Fund
  of Washington, L.P.
1568 Spring Hill Road, Suite 200
McLean, Virginia 22102 ....................        446,517                  5.2

(ii)  Directors (which includes all
      nominees) and Named Executives:

Brian M. Gallagher, Ph.D ..................        325,000(5)               3.7

Robert A. Ashley ..........................         96,975(6)               1.1

Nancy C. Broadbent ........................         87,000(7)               1.0

Helmer P.K. Agersborg, Ph.D ...............        121,209(8)               1.4

Peter R. Barnett, D.M.D ...................          7,000(9)                *

James E. Daverman .........................        921,313(10)             10.7

Robert J. Easton ..........................         23,689(11)               *

Stephen W. Ritterbush, Ph.D ...............        451,517(12)              5.3

Pieter J. Schiller ........................        395,299(13)              4.6

Terence E. Winters, Ph.D ..................        974,328(14)             11.4

(iii)  All Directors and officers as a
       group (12 persons) .................      3,467,330(15)             38.4

</TABLE>

- ----------


                                      -14-
<PAGE>


*       Less than 1%

(1)     Except as set  forth in the  footnotes  to this  table  and  subject  to
        applicable  community  property law, the persons named in the table have
        sole voting and investment power with respect to all shares.

(2)     Applicable percentage of ownership for each holder is based on 8,567,579
        shares of Common Stock outstanding on February 15, 1998, plus any Common
        Stock  equivalents and presently  exercisable  stock options or warrants
        held by each such  holder,  and  options or  warrants  held by each such
        holder which will become  exercisable  within 60 days after February 15,
        1998.

(3)     Includes  890,860  shares and 25,453  shares owned by Marquette  Venture
        Partners II, L.P. and MVP II Affiliates Fund, L.P., respectively.

(4)     Includes  613,946 shares and 11,054 shares owned by Delphi Ventures III,
        L.P. and Delphi Investments III, L.P., respectively.

(5)     Of such shares,  125,000 are subject to certain  rights of first refusal
        held by the Company,  of which 20,834 also are subject to  repurchase by
        the Company as of February  15, 1998.  See  "EXECUTIVE  COMPENSATION  --
        Summary of Compensation in fiscal 1997, 1996 and 1995". Includes 200,000
        shares  of  Common  Stock  underlying   options  which  are  or  may  be
        exercisable as of February 15, 1998 or 60 days after such date.

(6)     Includes 78,125 shares of Common Stock  underlying  options which are or
        may be exercisable as of February 15, 1998 or 60 days after such date.

(7)     Includes 62,000 shares of Common Stock  underlying  options which are or
        may be  exercisable  as of February 15, 1998 or 60 days after such date.
        Also includes 1,000 shares held as custodian to minor child.

(8)     Includes  32,500  shares of Common Stock  underlying  options  which are
        exercisable as of February 15, 1998 or 60 days after such date.

(9)     Includes  5,000  shares of Common  Stock  underlying  options  which are
        exercisable as of February 15, 1998 or 60 days after such date.

(10)    James E. Daverman is President of Marquette  Management  Partners,  LLC,
        the general partner of Marquette  Venture  Partners,  L.P. and a general
        partner  of MG II,  L.P.,  the  general  partner  of  Marquette  Venture
        Partners II, L.P. and MVP II Affiliates Fund, L.P. and, as such, has the
        power to vote or direct  the vote of and to  dispose  of or  direct  the
        disposition of the shares owned by Marquette  Venture  Partners II, L.P.
        and MVP II  Affiliates  Fund,  L.P.  Mr.  Daverman  expressly  disclaims
        beneficial  ownership  of such  shares,  except as to his  proportionate
        interest in Marquette  Venture  Partners II, L.P. and MVP II  Affiliates
        Fund,  L.P.  Includes  5,000 shares of Common Stock  underlying  options
        which are  exercisable  as of  February  15,  1998 or 60 days after such
        date.

(11)    Includes  10,000  shares of Common Stock  underlying  options  which are
        exercisable  as of February  15,  1998 or 60 days after such date.  Also
        includes 2,000 shares held as custodian to minor child.

(12)    Stephen W. Ritterbush,  Ph.D. is a general partner of Fairfax  Partners/
        The Venture Fund of Washington, L.P. and, as such, has the power to vote
        or direct the vote of and to dispose of or direct the disposition of the
        shares owned by Fairfax  Partners/The  Venture Fund of Washington,  L.P.
        Dr. Ritterbush  expressly disclaims beneficial ownership of such shares,
        except as to his proportionate  interest in Fairfax Partners/The Venture
        Fund  of  Washington,   L.P.  Includes  5,000  shares  of  Common  Stock
        underlying  options which are  exercisable as of February 15, 1998 or 60
        days after such date.

(13)    Pieter J. Schiller is a general partner of Advanced  Technology Ventures
        III, L.P. and, as such,  has the power to vote or direct the vote of and
        to dispose of or direct the  disposition of the shares owned by


                                      -16
<PAGE>


        Advanced  Technology Ventures III, L.P. Mr. Schiller expressly disclaims
        beneficial  ownership  of such  shares,  except as to his  proportionate
        interest in Advanced Technology Ventures III, L.P. Includes 5,000 shares
        of Common Stock underlying  options which are exercisable as of February
        15, 1998 or 60 days after such date.

(14)    Terence E. Winters, Ph.D. is a general partner of Columbine Venture Fund
        II, L.P.  and, as such,  has the power to vote or direct the vote of and
        to dispose of or direct the disposition of the shares owned by Columbine
        Venture  Fund  II,  L.P.  Dr.  Winters  expressly  disclaims  beneficial
        ownership of such  shares,  except as to his  proportionate  interest in
        Columbine  Venture Fund II, L.P.  Includes  5,000 shares of Common Stock
        underlying  options which are  exercisable as of February 15, 1998 or 60
        days after such date.

(15)    See Notes 5 through 14. Also  includes an aggregate of 64,000  shares of
        Common Stock  underlying  options granted to Douglas C. Gehrig and David
        P.  Pfeiffer  which are  exercisable  as of February 15, 1998 or 60 days
        after such date.


                                      -16-
<PAGE>


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
                 ----------------------------------------------

        As of April 1, 1998,  each of Advanced  Technology  Ventures III,  L.P.,
with which Mr. Schiller is affiliated,  and Marquette  Venture Partners II, L.P.
and MVP II Affiliates  Fund,  L.P., with which Mr. Daverman is affiliated,  held
390,299, 890,860 and 25,453 shares, respectively,  of the Company's Common Stock
which were previously  issued upon conversion of certain shares of the Company's
Series A, Series B or Series C Redeemable  Preferred  Stock  previously  held by
such entities.  Such shares of Common Stock are entitled to certain registration
rights and certain rights to participate in certain future offerings  undertaken
by the Company.

        In September  1995,  the Company and the then  holders of the  Company's
Series A,  Series B and  Series C  Redeemable  Preferred  Stock  entered  into a
Registration  Rights  Agreement (the "Rights  Agreement")  pursuant to which the
Company has granted certain  registration rights to such Stockholders.  Pursuant
to the Rights  Agreement,  at any time beginning six months after June 20, 1996,
the effective  date of the Company's  IPO, the holders of at least a majority of
the Common Stock issued upon the conversion of the Series A, Series B and Series
C Redeemable  Preferred  Stock (the  "Registrable  Securities")  have the right,
subject to certain  restrictions set forth in the Rights  Agreement,  to require
that the Company register the Registrable  Securities  requested by such holders
at the Company's  expense (on no more than two  occasions) on either a Form S-1,
Form S-2 or Form S-3 Registration Statement under the Securities Act of 1933, as
amended  (the  "Securities  Act").  The  Company is not,  however,  required  to
register any Registrable Securities unless such shares represent at least 10% of
the Company's  outstanding  shares of Common Stock, or, if less than 10%, if the
anticipated aggregate offering price exceeds $1,000,000.

        The  holders  of  Registrable  Securities  also  have  the  right  to an
unlimited  number of  registrations  on Form S-3 under the  Securities  Act. The
Company is not,  however,  required  to effect  such a  registration  unless the
requesting holders reasonably  anticipate having an aggregate  disposition price
of at least $500,000.

        Also  pursuant  to the  Rights  Agreement,  if, at any time  during  the
seven-year  period  commencing on the effective  date of the Company's  IPO, the
Company  proposes to register any of its Common Stock under the  Securities  Act
for sale to the public, the holders of the Registrable Securities have unlimited
piggyback  registration  rights at the  Company's  expense,  subject  to certain
restrictions set forth in the Rights Agreement.

        Also in  September  1995,  the  Company  granted to the then  holders of
Series A, Series B and Series C Redeemable  Preferred  Stock  certain  rights to
participate in certain future offerings  undertaken by the Company.  Such rights
to participate require that, with certain exceptions including,  but not limited
to, an underwritten  public  offering,  any time the Company  proposes to issue,
sell or exchange,  or reserve therefor,  any securities,  the Company must first
offer to sell to each of the  pre-conversion  holders of Series A,  Series B and
Series C  Redeemable  Preferred  Stock their  respective  pro rata share of such
securities  at a price  and on terms  identical  to the  price  and terms of the
securities proposed to be issued, sold or exchanged in the applicable offering.

        For  information  with respect to Drs.  Ritterbush  and Winters,  each a
member  of  the   Compensation   Committee,   see  "EXECUTIVE   COMPENSATION  --
Compensation Committee Interlocks and Insider Participation."

                     RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS
                     ---------------------------------------------------

        The Board of Directors of the Company  intends,  subject to  Stockholder
approval, to retain KPMG Peat Marwick LLP as independent auditors of the Company
for the year ending  December  31,  1998.  KPMG Peat  Marwick LLP also served as
independent  auditors of the  Company for 1997.  Neither the firm nor any of its
members has any direct or indirect  financial interest in or any connection with
the Company in any capacity other than as auditors.

        THE BOARD OF  DIRECTORS  RECOMMENDS A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF KPMG PEAT MARWICK LLP AS THE INDEPENDENT  AUDITORS OF THE COMPANY
FOR THE YEAR ENDING DECEMBER 31, 1998.


                                      -17-
<PAGE>


        One or more  representatives  of KPMG Peat  Marwick  LLP is  expected to
attend the Meeting and have an opportunity to make a statement and/or respond to
appropriate questions from stockholders.

        On January 19, 1996,  the Company  selected KPMG Peat Marwick LLP to act
as independent  accountants for the Company and informed the prior auditors, the
Company's independent accountants since January 1994, of its decision. The prior
auditors  conducted  the  Company's  audit for the period from  January 10, 1992
(inception) to December 31, 1993. In connection  with such audit,  there were no
disagreements with the prior auditors on any matters of accounting principles or
practices,  financial statement disclosure, or auditing scope or procedures. The
prior auditors' report on the Company's financial statements for the period from
January 10, 1992  (inception) to December 31, 1993 contained no adverse  opinion
or  disclaimer  of opinion and was not modified or qualified as to  uncertainty,
audit scope, or accounting  principles.  The decision to change  accountants was
approved by the Board of Directors of the Company.

                             STOCKHOLDERS' PROPOSALS
                             -----------------------

        Stockholders who wish to submit proposals for inclusion in the Company's
proxy  statement  and  form of proxy  relating  to the 1999  Annual  Meeting  of
Stockholders  must  advise the  Secretary  of the Company of such  proposals  in
writing by December 7, 1998.

                                  OTHER MATTERS
                                  -------------

        The Board of Directors  is not aware of any matter to be  presented  for
action at the  Meeting  other than the  matters  referred  to above and does not
intend to bring any other matters before the Meeting.  However, if other matters
should come before the Meeting,  it is intended that holders of the proxies will
vote thereon in their discretion.

                                     GENERAL
                                     -------

        The  accompanying  proxy is  solicited  by and on behalf of the Board of
Directors  of the  Company,  whose  notice of meeting is  attached to this Proxy
Statement,  and the  entire  cost  of such  solicitation  will be  borne  by the
Company.

        In  addition  to the  use of the  mails,  proxies  may be  solicited  by
personal  interview,  telephone  and telegram by  directors,  officers and other
employees  of the  Company  who  will not be  specially  compensated  for  these
services. The Company will also request that brokers,  nominees,  custodians and
other  fiduciaries  forward  soliciting  materials to the  beneficial  owners of
shares  held  of  record  by  such  brokers,  nominees,   custodians  and  other
fiduciaries.  The Company  will  reimburse  such  persons  for their  reasonable
expenses in connection therewith.

        Certain  information  contained in this Proxy Statement  relating to the
occupations  and security  holdings of directors  and officers of the Company is
based upon information received from the individual directors and officers.

        COLLAGENEX PHARMACEUTICALS, INC. WILL FURNISH, WITHOUT CHARGE, A COPY OF
ITS  REPORT  ON FORM  10-K FOR THE  YEAR  ENDED  DECEMBER  31,  1997,  INCLUDING
FINANCIAL  STATEMENTS AND SCHEDULES THERETO BUT NOT INCLUDING EXHIBITS,  TO EACH
OF ITS  STOCKHOLDERS  OF  RECORD  ON  MARCH  27,  1998,  AND TO EACH  BENEFICIAL
STOCKHOLDER  ON THAT DATE UPON WRITTEN  REQUEST MADE TO MS. NANCY C.  BROADBENT,
SECRETARY,  COLLAGENEX  PHARMACEUTICALS,  INC., 301 SOUTH STATE STREET, NEWTOWN,
PENNSYLVANIA  18940.  A  REASONABLE  FEE WILL BE CHARGED FOR COPIES OF REQUESTED
EXHIBITS.


                                      -18-
<PAGE>


        PLEASE DATE, SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST CONVENIENCE
IN THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN OF YOUR PROXY CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.

                                             By Order of the Board of Directors


                                             Nancy C. Broadbent,
                                             Secretary

Newtown, Pennsylvania
April 8, 1998



                                      -19-
<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

        The  undersigned  hereby  constitutes  and appoints Brian M.  Gallagher,
Ph.D. and Nancy C. Broadbent, and each of them, his or her true and lawful agent
and proxy with full power of  substitution  in each, to represent and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of  Stockholders  of the Company to be held at the Marriott  Hotel,  1201 Market
Street, Philadelphia,  Pennsylvania at 8:30 A.M., local time, on Monday, May 11,
1998,  and at any  adjournment  or  adjournments  thereof,  upon  the  following
proposals more fully  described in the Notice of Annual Meeting of  Stockholders
and Proxy Statement for the Meeting (receipt of which is hereby acknowledged).

        THIS PROXY WHEN PROPERLY  EXECUTED WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1 AND 2.

                  (continued and to be signed on reverse side)


<PAGE>


                 Please Detach and Mail In the Envelope Provided

A | X | Please mark your
        votes as in this
        example.

1. ELECTION OF        FOR        WITHHELD          Nominees:
   DIRECTORS.         | |          | |             Helmer P.K. Agersborg, Ph.D.
                                                   Peter R. Barnett, D.M.D
                                                   Brian M. Gallagher, Ph.D.
                                                   Robert J. Easton
   VOTE FOR all the nominees listed at right;      James E. Daverman
   except vote withheld from the following         Stephen W. Ritterbush, Ph.D.
   nominee(s) (if any).                            Pieter J. Schiller
                                                   Terence E. Winters, Ph.D.

   -----------------------------------------------------


2. APPROVAL OF PROPOSAL TO RATIFY                      FOR    AGAINST    ABSTAIN
   THE APPOINTMENT OF KPMG PEAT MARWICK                | |      | |        | |
   LLP AS THE INDEPENDENT AUDITORS OF THE COMPANY
   FOR THE YEAR ENDING DECEMBER 31, 1998.

3. In his or her discretion, the proxy is authorized to vote  upon other matters
   as may properly come before the Meeting.


                                   I will                    I will not
                                    | |                         | |
                                         attend the Meeting.


PLEASE MARK,  SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE ENCLOSED
ENVELOPE.

Signature of Stockholder         Signature of Stockholder         Dated:
                        ---------                        --------       --------
                                           IF HELD JOINTLY


Note:   This  proxy  must be signed  exactly as the name  appears  hereon.  When
        shares are held by joint  tenants,  both should sign. If the signer is a
        corporation, please sign full corporate name by duly authorized officer,
        giving full title as such. If the signer is a  partnership,  please sign
        in partnership name by authorized person.




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