COLLAGENEX PHARMACEUTICALS INC
8-K, 1999-03-25
PHARMACEUTICAL PREPARATIONS
Previous: ORION ACQUISITION CORP II, SC 13D, 1999-03-25
Next: FIRST UNION RESIDENTIAL SECURITIZATION TRANSACTIONS INC, 10-K, 1999-03-25





                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                         -------------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


Date of report (Date of earliest event reported)   March  19, 1999
                                                   ---------------


                        COLLAGENEX PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
              (Exact Name of Registrant as Specified in Charter)


        Delaware                     0-28308                    52-1758016
- --------------------------------------------------------------------------------
(State or Other Jurisdiction  (Commission File Number)        (IRS Employer
      of Incorporation)                                     Identification No.)


301 South State Street
Newtown, Pennsylvania                                              18940
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)                         (Zip Code)


Registrant's telephone number, including area code (215) 579-7388
                                                   --------------


- --------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)



<PAGE>


Item 5.  OTHER EVENTS.


      On March  19,  1999,  CollaGenex  Pharmaceuticals,  Inc.  (the  "Company")
entered into a Convertible  Loan and Security  Agreement (the "Loan  Agreement")
with OCM  Principal  Opportunities  Fund,  L.P.  ("OCM")  pursuant  to which the
Company issued OCM a convertible note raising $10,000,000 in gross proceeds.  In
accordance with the Loan Agreement,  the Company executed and delivered to OCM a
12% senior secured  convertible  note due March 18, 2000 in the principal amount
of $10,000,000 (the "Note"). The Note is mandatorily payable upon the closing of
that  certain  Stock  Purchase  Agreement  dated March 19,  1999 (the  "Purchase
Agreement"),  whereby the  Company  has agreed to sell to OCM and certain  other
investors shares of its Series D Cumulative  Convertible  Preferred Stock,  $.01
par  value  per  share,  at an  aggregate  purchase  price of  $20,000,000.  The
consummation  of the  Purchase  Agreement  is subject to,  among  other  things,
approval of such  transaction by the  stockholders  of the Company.  The Company
intends to seek such approval at its 1999 Annual Meeting of Stockholders. In the
event the Purchase Agreement is not consummated by June 30, 1999, OCM shall have
the option to convert the principal due under the Note into 1,538,462  shares of
Common Stock. The interest due under the Note is also convertible into shares of
Common Stock at a conversion price of $6.50 per share.

      The Loan Agreement contains certain covenants including those set forth in
the  Purchase  Agreement  which  are  incorporated  by  reference  into the Loan
Agreement.  Among other things,  the Note is secured by a first priority lien on
certain of the  Company's  existing  and  future  assets,  including  inventory,
accounts,  goods,  fixtures and general intangibles,  and all of the proceeds of
the foregoing.

      Prior to entering into the Note, the Company also executed an amendment to
its  Shareholder  Protection  Rights  Agreement  in order to  exclude  OCM as an
Acquiring Person (as defined therein) with respect to the transactions set forth
above.


                                      -2-
<PAGE>


Item 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

      (c)   Exhibits

              Exhibit No.                               Document
              -----------                               --------

                  4.1                    Amendment   No.   1   to    Shareholder
                                         Protection Rights  Agreement,  dated as
                                         of March 16, 1999,  between  CollaGenex
                                         Pharmaceuticals,   Inc.   and  American
                                         Stock Transfer & Trust Company.

                  10.1                   Convertible     Loan    and    Security
                                         Agreement  dated as of March 19,  1999,
                                         between  OCM  Principal   Opportunities
                                         Fund,      L.P.     and      CollaGenex
                                         Pharmaceuticals, Inc.

                  10.2                   Convertible  Note dated March 19, 1999,
                                         made  by  CollaGenex   Pharmaceuticals,
                                         Inc.   in   favor   of  OCM   Principal
                                         Opportunities Fund, L.P.

                  10.3                   Stock  Purchase  Agreement  dated March
                                         19,    1999,     between     CollaGenex
                                         Pharmaceuticals,  Inc.,  OCM  Principal
                                         Opportunities   Fund,  L.P.  and  other
                                         Purchasers set forth therein.


                                      -3-
<PAGE>


                                    SIGNATURE


      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.



                                    COLLAGENEX PHARMACEUTICALS, INC.



                                    By:  /s/ Brian M. Gallagher
                                       --------------------------------------
                                    Name:  Brian M. Gallagher, Ph.D.
                                    Title: President, Chief Executive Officer
                                            and Director

March 25, 1999


                                      -4-
<PAGE>


                                  EXHIBIT INDEX


              Exhibit No.                               Document
              -----------                               --------

                  4.1                    Amendment   No.   1   to    Shareholder
                                         Protection Rights  Agreement,  dated as
                                         of March 16, 1999,  between  CollaGenex
                                         Pharmaceuticals,   Inc.   and  American
                                         Stock Transfer & Trust Company.

                  10.1                   Convertible     Loan    and    Security
                                         Agreement  dated as of March 19,  1999,
                                         between  OCM  Principal   Opportunities
                                         Fund,      L.P.     and      CollaGenex
                                         Pharmaceuticals, Inc.

                  10.2                   Convertible  Note dated March 19, 1999,
                                         made  by  CollaGenex   Pharmaceuticals,
                                         Inc.   in   favor   of  OCM   Principal
                                         Opportunities Fund, L.P.

                  10.3                   Stock  Purchase  Agreement  dated March
                                         19,    1999,     between     CollaGenex
                                         Pharmaceuticals,  Inc.,  OCM  Principal
                                         Opportunities   Fund,  L.P.  and  other
                                         Purchasers set forth therein.



                                      -5-




                               AMENDMENT NO. 1 TO
                     SHAREHOLDER PROTECTION RIGHTS AGREEMENT

      THIS AMENDMENT NO. 1 dated as of March 16, 1999 (the  "Amendment")  to the
Shareholder  Protection  Rights  Agreement  dated as of September  15, 1997 (the
"Agreement"), between CollaGenex Pharmaceuticals,  Inc., a Delaware company (the
"Company") and American  Stock  Transfer & Trust  Company,  as Rights Agent (the
"Agent").

      NOW  THEREFORE,  in  consideration  of the premises  and mutual  covenants
contained herein,  and intending to be legally bound hereby,  the parties hereto
agree as follows:

     1.  AMENDMENT.  The  definition  of an  Acquiring  Person,  as contained in
Section  1.1 of the  Agreement  shall  be  revised  in its  entirety  to read as
follows:

      ""Acquiring  Person"  shall mean any Person who is a  Beneficial  Owner of
      more than the  Specified  Percentage of the  outstanding  shares of Common
      Stock;  provided,  however,  that the term  "Acquiring  Person"  shall not
      include  any  Person  (i) who is the  Beneficial  Owner  of more  than the
      Specified  Percentage  (as  defined  below) of the  outstanding  shares of
      Common  Stock on the  date of this  Agreement,  or who  shall  become  the
      Beneficial Owner of more than the Specified  Percentage of the outstanding
      shares of Common Stock solely as a result of an acquisition by the Company
      of shares of Common  Stock,  or who shall become the  Beneficial  Owner of
      more than the  Specified  Percentage of the  outstanding  shares of Common
      Stock as a result of the  transactions  contemplated by that certain Stock
      Purchase  Agreement  dated  March  1999,  by and among the Company and the
      Investor and Purchasers set forth therein,  until such time as any of such
      Persons shall become the Beneficial  Owner (other than by means of a stock
      dividend or stock split) after the date hereof of an  additional 1% of the
      outstanding  shares of Common Stock,  provided,  that,  for the purpose of
      determining  whether  any Person has  become  the  Beneficial  Owner of an
      additional  1% of the  outstanding  shares of Common  Stock,  compensatory
      management stock options and other stock-based management awards issued by
      the  Company  subsequent  to the  date  of  this  Agreement  shall  not be
      included, (ii) who becomes the Beneficial Owner of more than the Specified
      Percentage  of the  outstanding  shares of Common  Stock but who  acquired
      Beneficial  Ownership  of  shares  of  Common  Stock  without  any plan or
      intention  to  seek or  affect  control  of the  Company,  if such  Person
      promptly enters into an irrevocable  commitment to divest,  and thereafter
      promptly  divests  (without  exercising or retaining any power,  including
      voting,  with respect to such shares),  sufficient  shares of Common Stock
      (or securities  convertible  into,  exchangeable  into or exercisable  for
      Common  Stock) so that such Person  ceases to be the  Beneficial  Owner of
      more than the  Specified  Percentage of the  outstanding  shares of Common
      Stock or (iii) who  Beneficially  Owns shares of Common  Stock  consisting
      solely of one or more of (A)  shares of Common  Stock  Beneficially  Owned
      pursuant to the grant or exercise of an option  granted to such Person (an
      "Option  Holder") by the Company in connection  with an agreement to merge
      with, or acquire,  the Company  entered into prior to a Flip-in Date,

<PAGE>


      (B) shares of Common Stock (or securities  convertible into,  exchangeable
      into or exercisable for Common Stock),  Beneficially  Owned by such Option
      Holder  or its  Affiliates  or  Associates  at the  time of  grant of such
      option,  and (C) shares of Common Stock (or securities  convertible  into,
      exchangeable  into or exercisable for Common Stock) acquired by Affiliates
      or Associates of such Option Holder after the time of such grant which, in
      the aggregate,  amount to less than 1% of the outstanding shares of Common
      Stock. In addition,  the Company, any wholly-owned  Subsidiary (as defined
      below) of the Company and any employee  stock  ownership or other employee
      benefit plan of the Company or a  wholly-owned  Subsidiary  of the Company
      shall not be an Acquiring Person."

     2. EFFECT ON THE AGREEMENT.  Except as expressly amended by this Amendment,
the Agreement shall remain in full force and effect.

     3.  GOVERNING  LAW.  This  Amendment  shall be governed by and construed in
accordance with the laws of the State of Delaware.

     4.   COUNTERPARTS.   This   Amendment  may  be  executed  in  one  or  more
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together shall constitute a single instrument.

     5. EFFECTIVE DATE. This Amendment shall be effective  immediately  prior to
the execution by the Company of the Stock Purchase Agreement.

      IN WITNESS WHEREOF, the parties have executed and delivered this Amendment
as of the date first above written.

                                    COLLAGENEX PHARMACEUTICALS, INC.


                                    By: /s/ Nancy C. Broadbent
                                        -------------------------------------
                                        Nancy C. Broadbent
                                        Vice President and Chief Financial
                                        Officer


                                    AMERICAN STOCK TRANSFER & TRUST COMPANY


                                    By: /s/ Herbert J. Lemmer
                                        -------------------------------------
                                        Herbert J. Lemmer
                                        Vice President




                                     - 2 -





                     CONVERTIBLE LOAN AND SECURITY AGREEMENT


          This is a Convertible Loan and Security  Agreement (the  "Agreement"),
dated as of March 19, 1999,  by and between OCM  PRINCIPAL  OPPORTUNITIES  FUND,
L.P., a Delaware limited partnership, having its principal office at c/o Oaktree
Capital  Management,  LLC,  333 South Grand  Avenue,  28th Floor,  Los  Angeles,
California 90071 ("Lender"),  and COLLAGENEX  PHARMACEUTICALS,  INC., a Delaware
corporation,  having its principal  office at 301 South State  Street,  Newtown,
Pennsylvania 18940 ("Borrower").

                                   BACKGROUND

Lender,  Borrower and other Persons named therein are parties to a certain Stock
Purchase Agreement of even date herewith (the "Purchase Agreement"), pursuant to
which  Lender has agreed to purchase  from  Borrower  and Borrower has agreed to
sell to Lender shares of Borrower's  Series D Cumulative  Convertible  Preferred
Stock,  one-cent  ($0.01)  par value per share  ("Series  D  Preferred  Stock"),
subject to the terms and  conditions  set forth in the Purchase  Agreement  (the
"Purchase  Transaction").  One of the  conditions  to  the  consummation  of the
Purchase  Transaction is that the Borrower obtain the approval of the holders of
a majority  of the  Borrower's  Common  Stock (as  hereinafter  defined)  to the
Purchase  Transaction  (the  "Stockholders  Approval").  Until the  Stockholders
Approval  is obtained  in  accordance  with the  Purchase  Agreement,  Lender is
willing  to make  this  Convertible  Loan (as  defined  below) to  Borrower  and
Borrower is desirous of obtaining such loan from Lender on the terms and subject
to the conditions set forth in this Agreement.

                                      TERMS

          In   consideration   of  the  mutual  promises  and  covenants  herein
contained,  and intending to be legally bound hereby,  Lender and Borrower agree
as follows:

                             SECTION 1 - DEFINITIONS

1.1 As used in this  Agreement,  the  following  terms shall have the  following
meanings:

          (A)  "Accounts" and "General  Intangibles"  have the meanings given to
those terms in the Uniform Commercial Code of the Commonwealth of Pennsylvania.

          (B)  "Affiliate"  of a Person shall mean (i) a Person that directly or
indirectly,  through one or more intermediaries,  controls, is controlled by, or
is  under  common  


<PAGE>


control with, the first-mentioned Person, and (ii) an "associate",  as that term
is defined in Rule 12b-2  promulgated under the Exchange Act as in effect on the
date of this Agreement.

          (C) "Collateral" means all the collateral described in Section 4.1.

          (D) "Common Stock" means the common stock of Borrower,  par value $.01
per share.

          (E) "Convertible Loan" has the meaning set forth in Section 2.1.

          (F) "Convertible Note" has the meaning set forth in Section 2.1.

          (G) "Event of Default" means an event specified in Section 8.1.

          (H) "Financial Statements" means the consolidated financial statements
of Borrower.

          (I) "Financing Statements" has the meaning set forth in Section 4.3.

          (J)  "Indebtedness"  means all items of  indebtedness,  obligation  or
liability incurred by Borrower to any Person other than Lender,  whether matured
or unmatured, liquidated or unliquidated,  direct or indirect, joint or several,
including,  but  without  limitation  or  duplication:  (1) all  obligations  of
Borrower for borrowed money, or with respect to deposits or advances of any kind
to Borrower,  (2) all  obligations of Borrower  evidenced by bonds,  debentures,
notes or  similar  instruments,  (3) all  obligations  of  Borrower  upon  which
interest  charges are  customarily  paid, (4) all  obligations of Borrower under
conditional  sale or other  title  retention  agreements  relating  to  property
purchased by Borrower,  (5) all obligations of Borrower issued or assumed as the
deferred  purchase  price of  property  or services  (excluding  obligations  of
Borrower to  creditors  for raw  materials,  inventory,  services  and  supplies
incurred in the ordinary  course of Borrower's  business),  (6) all  capitalized
lease obligations of Borrower, (7) all obligations of others secured by any Lien
on  property  or  assets  owned or  acquired  by  Borrower,  whether  or not the
obligations  secured thereby have been assumed,  (8) all obligations of Borrower
under interest rate or currency hedging  transactions (valued at the termination
value  thereof),  (9) all  letters of credit  issued for the account of Borrower
(excluding  letters of credit  issued for the  benefit of  suppliers  to support
accounts payable to suppliers incurred in the ordinary course of business),  and
(10) all guarantees and  arrangements  having the economic effect of a guarantee
of Borrower of any indebtedness of any other Person.

          (K)  "Inventory"  means  all goods  now  owned or  hereafter  acquired
intended  for sale or lease,  or to be furnished  under  contracts of service by
Borrower,  including,  without limitation,  all raw materials, goods in process,
finished goods, materials and supplies of every nature and description now owned
or hereafter  owned by Borrower,  used or which might be


                                     - 2 -
<PAGE>


used in  connection  with the  manufacturing,  packing,  shipping,  advertising,
selling,  leasing or furnishing  of such goods or otherwise  used or consumed in
Borrower's business.

          (L) "Laws" means all ordinances, statutes, rules, regulations, orders,
injunctions,  writs or decrees of any  government  or political  subdivision  or
agency thereof, or any court or similar entity.

          (M)  "Loan   Documents"  means  the  Convertible  Note  and  Financing
Statements  described herein, the Security Agreement in the form attached hereto
as Exhibit D and any other  document,  agreement or instrument  made pursuant to
this Agreement or contemplated hereby.

          (N)  "Material  Adverse  Effect"  means (i) any adverse  change in the
condition  (financial  or  otherwise),  assets  (including  without  limitation,
patents, licenses to patents and Intellectual Property), liabilities,  business,
results of operations or prospects of Borrower and its Affiliate,  which change,
individually or in the aggregate,  is material to the Company or its subsidiary,
or (ii) any event,  matter,  condition  or effect  which  impairs the ability of
Borrower or its  Affiliate  to perform on a timely basis its  obligations  under
this Agreement,  the Convertible  Loan, the Convertible Note or the consummation
of the transactions  contemplated by this Agreement.  Materiality  under clauses
(i) or (ii) hereof shall be as determined in good faith by Lender.

          (O) "Obligations" means the obligations of:

               (1)  Borrower  to  pay  the  principal  of  and  interest  on the
Convertible Note in accordance with the terms thereof, and to satisfy all of its
other indebtedness,  liabilities and obligations of Borrower to Lender, of every
kind and description,  whether hereunder or otherwise, now existing or hereafter
incurred,  direct or  indirect,  absolute or  contingent,  due or to become due,
including, without limitation, all interest, fees, charges and expenses, and any
extensions,  modifications,  renewals  of  such  indebtedness  or  substitutions
therefor;

               (2)  Borrower to repay to Lender all  amounts  advanced by Lender
hereunder or otherwise on Borrower's behalf,  including, but without limitation,
advances  for  principal  or  interest,   payments  to  prior  secured  parties,
mortgagees,  or lienors, or for taxes,  levies,  insurance,  rent, repairs to or
maintenance of any of the Collateral; and

               (3) Borrower to reimburse Lender, on demand,  for all of Lender's
expenses  and  costs,  including  the  fees  and  expenses  of its  counsel,  in
connection  with the  preparation,  administration,  amendment,  modification or
enforcement of this Agreement and the documents required  hereunder,  including,
without  limitation,  any proceeding brought or threatened to enforce payment of
any of the obligations referred to in the foregoing paragraphs (1) and (2).

          (P) "Permitted Liens" means:


                                     - 3 -
<PAGE>


               (1) liens for taxes, assessments, or similar charges, incurred in
the ordinary course of business that are not yet due and payable;

               (2) pledges or deposits  made in the ordinary  course of business
to secure  payment of workers'  compensation,  or to  participate in any fund in
connection with workers' compensation,  unemployment insurance,  old-age pension
or other social security programs;

               (3) liens of mechanics, materialmen,  warehousemen,  carriers, or
other like  liens,  security  obligations  incurred  in the  ordinary  course of
business which are not yet due and payable;

               (4) liens in favor of Lender;

               (5) the  following,  if the  validity or amount  thereof is being
contested in good faith by appropriate and lawful  proceedings,  so long as levy
and  execution  thereon  have been stayed and  continue  to be stayed,  adequate
reserves  are set aside  therefor,  and they could not,  individually  or in the
aggregate,  have a  Material  Adverse  Effect  on the value of the  property  of
Borrower, or materially impair the use thereof in the operation of its business:

                    (a)  claims or liens for  taxes or  assessments,  but not in
          excess of $50,000;

                    (b) claims or liens of mechanics, materialmen, warehousemen,
          carriers or other like liens, but not in excess of $50,000; and

                    (c)  adverse  judgments  on  appeal,  but not in  excess  of
          $50,000.

          (Q)  "Person"   means  any   individual,   corporation,   partnership,
association,   joint-stock  company,  trust,  incorporated  organization,  joint
venture, court or government or political subdivision or agency thereof.

          (R) "Purchase  Agreement"  has the meaning set forth in the Background
section to this Agreement.

          (S)  "Records"  means  records,  orders,   receipts,   correspondence,
memoranda,  tapes,  data  processing  cards,  discs,  papers,  tabulating  runs,
programs, books, journals and other documents, or transcribed information of any
type, whether expressed in ordinary or machine language.


                                     - 4 -
<PAGE>


          (T) "Security  Agreement"  means the  Intellectual  Property  Security
Agreement  of even date  herewith  between  Borrower  and  Lender in the form of
Exhibit D.

          (U) "Series D Preferred Stock" means the shares of Borrower's Series D
Cumulative  Convertible  Preferred  Stock,  par  value  $.01  per  share,  to be
purchased   by   Lender   at   the   Closing   of   the   Purchase    Agreement.

          (V) "Special  Power of Attorney"  has the meaning set forth in Section
4.3.

          (W)  "Stockholders  and  Registration   Rights  Agreement"  means  the
Stockholders  and  Registration  Rights  Agreement  dated as of the date hereof,
between Borrower,  Lender and the other Persons named therein, the Schedules and
Exhibits thereto, and any certificate or other document required thereby, as the
same may be amended from time to time.

          (X)  "Subsidiary"  means  any  corporation  with  respect  to  which a
majority of the voting stock is owned directly or indirectly by Borrower.

     1.2 CAPITALIZED  TERMS. Any capitalized term not otherwise  defined in this
Agreement  shall  have  the  meaning  ascribed  to  such  term  in the  Purchase
Agreement.

     1.3 ACCOUNTING TERMS. Any accounting terms used in this Agreement which are
not specifically  defined herein shall have the meanings  customarily given them
in    accordance    with    generally    accepted     accounting     principles.

                          SECTION 2 - CONVERTIBLE LOAN

2.1 SENIOR SECURED CONVERTIBLE TERM LOAN.

          (A) General  Terms.  Subject to the terms hereof,  Lender will lend to
Borrower the principal sum of US Ten Million Dollars (US  $10,000,000.00),  on a
senior secured term basis, convertible in accordance with this Agreement and the
Convertible  Note  (the  "Convertible  Loan").  The  Convertible  Loan  shall be
convertible, at Lender's option, in whole or in part, in accordance with Section
3 of the Convertible Note into shares of Borrower's Common Stock.

          (B) Convertible Note. Borrower shall simultaneously with the execution
and  delivery  of this  Agreement,  execute and deliver to Lender its 12% Senior
Secured  Convertible Note due March 18, 2000 (the  "Convertible  Note"),  in the
principal amount of US Ten Million Dollars  $10,000,000.00  in the form attached
hereto as Exhibit A.


                                     - 5 -
<PAGE>


          (C)  Payments of  Principal.  Except as provided in Section  2.3,  the
principal  sum of this  Convertible  Loan  shall  be due and  payable  in on the
first(1st)   anniversary   date  of  the  issuance  of  the  Convertible   Note.

          (D) Interest  Rate and  Payments of  Interest.  Interest on the unpaid
balance of principal from time to time outstanding  shall be payable at the rate
of twelve percent (12%) per annum and shall be payable quarterly,  in arrears on
June 30,  September 30,  December 31 and March 31 of every year, and at maturity
(whether by  acceleration  or  otherwise)  and upon the making of the  mandatory
prepayment as provided for in Section 2.3. hereof.

     2.2 COMPUTATION OF INTEREST.

          (A) Interest on the Convertible  Loan shall be calculated on the basis
of a 360-day year,  consisting  of twelve (12) thirty (30) day months,  counting
the actual  number of days  elapsed.  All accrued and unpaid  interest  shall be
payable  upon  the  maturity  of the  Convertible  Loan,  whether  by  mandatory
prepayment, acceleration or otherwise.

          (B) If, at any time, the interest rate  applicable to the  Convertible
Loan  shall be  deemed by any  competent  court of law,  governmental  agency or
tribunal to exceed the  maximum  rate of interest  permitted  by any  applicable
Laws,  then,  for such time as the  applicable  rate of interest would be deemed
excessive, its application shall be suspended and there shall be charged instead
the maximum rate of interest permissible under such Laws.

     2.3 MANDATORY  PREPAYMENT.  In the event that the Purchase  Transaction  is
consummated  as  contemplated  in the Purchase  Agreement no later than June 30,
1999,  Borrower  shall  be  required  to  prepay  the  Convertible  Loan and the
Convertible  Note in whole, but not in part, out of the proceeds of the Purchase
Transaction.  Except  as  expressly  set  forth in this  Section  2.3,  under no
circumstances shall Borrower be permitted to prepay the Convertible Loan and the
Convertible Note.

     2.4 PAYMENT TO LENDER.  All sums payable to Lender  hereunder shall be paid
directly to Lender by confirmed wire transfer of immediately available funds. If
any  payment of  principal,  interest or other sum shall be due and payable on a
day other than a banking day,  then such payment shall be due and payable on the
next  banking day  preceding  the due date for such  payment.  Lender shall send
Borrower  statements of all amounts due  hereunder,  which  statements  shall be
considered  correct  and  conclusively  binding  on  Borrower,  unless  Borrower
notifies  Lender of any statement  which it deems to be incorrect  within thirty
(30) calendar days of the mailing of such statement by Lender to Borrower.

                        SECTION 3 - CONDITIONS PRECEDENT


                                     - 6 -
<PAGE>


3.1 DELIVERY OF DOCUMENTS. The obligation of Lender to enter into this Agreement
and to  make  the  financial  accommodations  described  herein  is,  except  as
otherwise provided below,  subject to the delivery by Borrower to Lender, at the
date of closing hereunder (the "Closing"),  the following, in form and substance
satisfactory to Lender:

          (A) this Agreement, properly executed by Borrower;

          (B) the  Stockholders  and  Registration  Rights  Agreement,  properly
executed by Borrower;

          (C) the Purchase Agreement, properly executed by Borrower;

          (D) the  Convertible  Note in the form  attached  hereto as Exhibit A,
properly executed by Borrower and dated the date of this Agreement;

          (E) the Financing Statements required by Section 4.3 hereof;

          (F) the  Special  Power of  Attorney  in the form  attached  hereto as
Exhibit B;

          (G) copies of the  resolutions  of the Board of  Directors of Borrower
(certified as of the date of Closing by the secretary of Borrower),  authorizing
the execution,  delivery and performance of this  Agreement,  the Loan Documents
and each other document to be delivered by Borrower pursuant hereto;

          (H) a copy,  certified as of the most recent date  practicable  by the
Secretary of State of the State of Delaware, of the certificate of incorporation
of Borrower  and of  registration  of  fictitious  names,  together  with a copy
(certified by the secretary of Borrower) of Borrower's bylaws, and a certificate
(dated as of the date of the Closing) of the secretary of Borrower to the effect
that such  certificate of  incorporation  and bylaws have not been amended since
the date of the aforesaid certifications;

          (I) a  certificate  (dated  as of  the  date  of the  Closing)  of the
secretary  of Borrower  as to the  incumbency  and  signatures  of the  officers
thereof;

          (J) a  certificate  of good  standing  with respect to Borrower  dated
within two (2 ) business  days prior to the date of  Closing,  from the State of
Delaware and from each state in which it is qualified to transact business;

          (K) a certificate  (dated as of the date of the Closing) signed by the
chief financial officer of Borrower to the effect that all  representations  and
warranties of Borrower  contained  herein are true,  correct and complete in all
material respects;


                                     - 7 -
<PAGE>


          (L) the opinion of Borrower's  counsel in the form attached  hereto as
Exhibit C-1;

          (M) the  opinion of  Borrower's  patent  counsel in the form  attached
hereto as Exhibit C-2;

          (N) Uniform Commercial Code, Judgment,  Federal Tax Lien and Franchise
Tax Searches satisfactory to Lender; and

          (O)  such  other  certificates  and  documents  as may  be  reasonably
required by Lender.

                         SECTION 4 - COLLATERAL SECURITY

4.1 Rights in Property Held by Borrower. As security for the prompt satisfaction
of all  Obligations,  including  payment of the  indebtedness  evidenced  by the
Convertible  Note,  Borrower  hereby  grants  Lender a lien upon and  continuing
security interest in all of the following,  wherever located,  whether now owned
or existing or hereafter acquired,  together with all replacements  therefor and
all proceeds  (including,  but without limitation,  insurance proceeds thereof):

          (A) all of Borrower's Inventory,  including existing Inventory and all
Inventory hereafter coming into existence;

          (B) all of Borrower's  Accounts,  including all existing  Accounts and
all Accounts  hereafter  coming into  existence,  together  with all  documents,
contracts, lien and security instruments and guarantees relating thereto;

          (C) all  interest of Borrower  now  existing or  hereafter  arising in
goods as to which an Account  for goods  sold or  delivered  has arisen  (herein
sometimes called  "Goods"),  including the rights of reclamation and stoppage in
transit;

          (D)  all  of  Borrower's  right,  title  and  interest  in  and to all
fixtures, appliances,  machinery,  equipment, furniture, leasehold improvements,
tools  and  supplies  now owned or  hereafter  acquired,  together  with (i) all
additions,  parts,  fittings,   accessories,   special  tools,  attachments  and
accessories  now  and  hereafter  affixed  thereto  and/or  used  in  connection
therewith, and (ii) all replacements thereof and substitutions therefor;

          (E)  all  of  Borrower's  General  Intangibles   (including,   without
limitation,   Intellectual  Property,  things  in  action,  contractual  rights,
goodwill, rights to performance,  licenses,  distributorship rights, copyrights,
trademarks and patents) now existing or hereafter in existence;

          (F) all notes, drafts, acceptances,  instruments,  documents of title,
policies and certificates of insurance  (including,  without limitation,  credit
insurance),  chattel paper,


                                     - 8 -
<PAGE>


guarantees  and securities  (domestic and foreign) now or hereafter  received by
Borrower or in which  Borrower  has or acquires  an interest  pertaining  to the
foregoing;

          (G) all other rights of Borrower now existing or hereafter  arising to
the payment of money  (including,  without  limitation,  tax refunds,  choses in
action, settlements and judgments);

          (H) all cash and non-cash proceeds, products and insurance proceeds of
the foregoing; and

          (I) all Records pertaining to the foregoing.

     4.2  PRIORITY OF LIENS.  The Borrower  shall take all actions  necessary so
long as any  Obligations  are  outstanding to ensure that the foregoing Liens in
favor of Lender  shall be first  and  prior to any  other  Liens in favor of any
other Person.

     4.3 FINANCING STATEMENTS.

          (A) Borrower will:

               (1)  immediately  execute such  financing  statements  (including
amendments thereto and continuation  statements  thereof) and other documents in
form  satisfactory  to Lender as Lender may specify to perfect or  continue  the
perfection  of  any  security   interest   granted  to  Lender  (the  "Financing
Statements");

               (2) pay or reimburse  Lender for all costs of filing or recording
the same in such public offices as Lender may designate; and

               (3) take such other  steps as Lender may  reasonably  direct,  to
perfect Lender's interest in the Collateral.

          (B) In addition to the foregoing,  and not in limitation  thereof,  to
the extent  lawful,  Borrower  hereby  appoints  Lender as its  attorney-in-fact
(without  requiring  Lender to act as such) to execute  and file any  schedules,
assignments, instruments, documents and financing statements in its name, and to
perform all other acts that Lender deems appropriate to perfect and continue its
security  interest in, and to protect and  preserve,  the  Collateral.  Borrower
shall  execute and deliver to lender at Closing the Special Power of Attorney in
the form attached hereto as Exhibit B (the "Special Power of Attorney").

                  SECTION 5 - BORROWER'S AFFIRMATIVE COVENANTS

          Borrower  covenants  and agrees that,  from and after the date of this
Agreement  and so long as Borrower  shall be indebted to Lender,  unless  Lender
shall  otherwise  consent  in  writing,


                                     - 9 -
<PAGE>


it shall comply with each of the covenants in the Purchase Agreement,  which are
hereby  incorporated  by  reference  herein  and  made a part  hereof,  and.  in
addition, comply with the following covenants:

5.1 NOTATION OF SECURITY INTEREST.  If requested by Lender,  Borrower shall mark
its Records concerning the Collateral in a manner satisfactory to Lender to show
Lender's security interest therein;  and shall, at Lender's request,  notify all
warehouses,  warehousemen, agents, landlords, processors or others in possession
of Collateral of Lender's  security  interest in such  Collateral,  and instruct
them to hold such  Inventory  for  Lender's  account  and  subject  to  Lender's
instructions.

     5.2 PAYMENT OF TAXES,  ASSESSMENT,  CHARGES AND CLAIMS. Borrower shall duly
pay or discharge or cause to be paid or discharged,  and shall cause each of its
subsidiaries  duly to pay or discharge  the  following  before they shall become
delinquent:  (a) all material taxes, assessments and governmental charges levied
or imposed upon Borrower or any of its  subsidiaries or upon the income,  profit
or property of Borrower or any of its subsidiaries,  and (b) all material lawful
claims for labor, materials and supplies which, if unpaid, might by law become a
material  lien  upon  the  property  of  Borrower  or any  of its  subsidiaries;
provided,  however,  that Borrower  shall not be required to pay or discharge or
cause to be paid or discharged (but shall make adequate  provision for) any such
tax,  assessment,  charge or claim whose  amount,  applicability  or validity is
being contested in good faith by appropriate  proceedings and for which adequate
provision has been made.

     5.3 BOOKS AND RECORDS AND OTHER DOCUMENTS. Borrower shall, at all times and
in  accordance  with  generally  accepted  accounting  principles,  consistently
applied,  if  applicable,  keep  complete and accurate  Records  concerning  its
business,  affairs and  operations  and  concerning  its  properties and assets,
including,  but not limited to, its corporate  minute books and bylaws and shall
deliver to Lender  promptly upon the Lender's  request (i) all  instruments  and
chattel  paper  (including  all executed  copies  thereof,  except such executed
copies retained by the obligors thereunder) representing proceeds of Collateral,
and (ii) such  other  information  with  respect  to any of the  Collateral  and
additional  copies of any or all of such papers or writings related thereto,  as
the Lender may in its sole discretion  deem to be necessary,  all of which shall
be at the sole expense of Borrower.

     5.4 INSPECTIONS.  Borrower shall,  upon reasonable notice and during normal
business hours,  permit a person  designated by Lender to inspect or examine the
properties  and  assets  of  Borrower,   including,  but  not  limited  to,  the
Collateral,  and further,  to examine,  check, audit, make copies of or extracts
from any of the Records of Borrower  or other data  relating to the  Collateral,
all without hindrance or delay.

     5.5 COLLECTION AND RECORDS OF ACCOUNTS. Borrower shall collect its Accounts
only in the ordinary  course of business,  and shall keep  accurate and complete
Records   of  its   Accounts,   consistent   with  sound   business   practices.


                                     - 10 -
<PAGE>


     5.6 Notifications.  Borrower shall promptly notify Lender in writing of the
following  and, if requested by Lender,  shall  deliver to Lender  copies of all
documents relating thereto:

          (A) any  litigation  affecting  Borrower,  whether or not the claim is
covered  by  insurance,  or any  suit or  administrative  proceeding  which  may
materially and adversely affect the Collateral or Borrower's  business,  assets,
operations or condition, financial or otherwise;

          (B) the  occurrence  of any event  described  in  Section  4043 of the
Employee  Income  Security  Act of 1974,  as  amended  ("ERISA"),  or receipt by
Borrower of any notice that it is not in full compliance  with the  requirements
of ERISA and regulations  thereunder;  or receipt by Borrower of notice from the
administrator  of any  multiemployer  plan to  which  Borrower  or any  Commonly
Controlled  Entity  (as  defined  in  Section  6.18  of this  Agreement)  has an
obligation to contribute that such plan has been placed in reorganization;

          (C) any labor dispute to which Borrower is or may become subject which
could have a Material  Adverse  Effect,  individually  or in the  aggregate,  on
Borrower's  business,  or the expiration of any labor contract to which Borrower
is a party or bound;

          (D) any violation of any law, statute,  regulation or ordinance of any
governmental  entity,  or of any agency  thereof,  applicable to Borrower  which
could have a Material Adverse Effect,  individually or in the aggregate,  on the
Collateral or Borrower's business, assets, operations or condition, financial or
otherwise;

          (E)  Borrower's  default under any note,  indenture,  loan  agreement,
mortgage, lease or other agreement to which Borrower is a party or bound;

          (F) any default under any Indebtedness or under any indebtedness owing
to  Borrower,  except  trade  receivables  which in the  aggregate do not exceed
$250,000;

          (G) any summons, citation,  directive,  information request, notice of
potential  responsibility,  notice of violation  or  deficiency,  order,  claim,
complaint,  investigation,  proceeding, judgment, letter or other communication,
written or oral,  to Borrower from the United  States  Environmental  Protection
Agency or other federal, state or local agency or authority, or any other entity
or individual,  public or private,  concerning any intentional or  unintentional
act or omission which involves generation, use, storage, transport,  disposal or
release of hazardous or toxic substances; and

          (H)  any  change  in  Borrower's  business,   assets,   operations  or
condition,  financial or otherwise that could, individually or in the aggregate,
have a Material  Adverse  Effect on Borrower or any of its  Affiliates or on the
ability of Borrower to repay the Convertible  Loan and the Convertible  Note, as
set forth in this Agreement.


                                     - 11 -
<PAGE>


     5.7 OTHER LIENS,  SECURITY INTERESTS;  FINANCING  STATEMENT  JURISDICTIONS.
Borrower shall keep  Collateral  free from all Liens,  of every kind and nature,
other than Permitted  Liens and Liens in favor of Lender.  Lender shall have the
absolute  right  at any  time and from  time to time to  obtain,  at  Borrower's
expense, financing statements and lien searches to verify the liens on, security
interests in and claims against all or a portion of the Collateral. Schedule 5.7
sets forth a complete and accurate list of (i) all jurisdictions in which any of
the Collateral is situated;  and (ii) all  jurisdictions in which Lender will be
required to file Financing  Statements to perfect its security  interest in such
Collateral.

     5.8 NOTICE OF  DEFAULT.  If any  officer of  Borrower  knows or should have
known  after due inquiry of any Event of Default  which  shall have  occurred or
knows of the  occurrence of any event which,  upon notice or passage of time, or
both, would  constitute an Event of Default,  Borrower shall  immediately,  upon
acquiring  knowledge  of  same,  furnish  to  Lender  a  statement  as  to  such
occurrence,  specifying the nature and extent  thereof.  If Borrower  receives a
notice of default from any creditor other than Lender, Borrower shall deliver to
Lender a copy of such notice of default immediately upon its receipt thereof.

     5.9 DEFENSE OF TITLE AND FURTHER  ASSURANCES.  Borrower  shall, at its sole
expense, defend the title to the Collateral and promptly, upon Lender's request,
do, execute, acknowledge and deliver or cause to be done, executed, acknowledged
and delivered, all such further acts, deeds, instruments,  transfers,  powers of
attorney,  mortgages or  assurances  as may be required in  connection  with the
transactions  contemplated by this Agreement,  including any security agreement,
financing statement or other writing necessary to evidence, preserve, protect or
enforce  Lender's  rights and interests to or in the  Collateral or in any other
collateral security agreed to by the parties hereto.

     5.10 AUTHORIZATION TO ACCOUNTANTS.  Borrower hereby irrevocably  authorizes
and directs all accountants and auditors  employed by it at any time while there
are any sums  owed  during  the term of this  Agreement,  and  until  all of the
Obligations  have been fully paid and  discharged,  to  exhibit  and  deliver to
Lender, at Lender's request,  copies of Borrower's financial  statements,  trial
balances  or  other  accounting   records  of  any  sort  in  their  possession.

     5.11 COMPLIANCE WITH AGREEMENT.  Borrower shall observe, perform and comply
with all of Borrower's  covenants made in this Agreement,  the Convertible  Note
and with all material agreements to which it is subject.

     5.12  DEPRECIATION OF COLLATERAL.  Borrower shall promptly notify Lender of
any event causing  material loss or  depreciation in the value of the Collateral
and set forth the amount of such loss or  depreciation.  In the event  Lender so
determines that such loss or  depreciation in value could have,  individually or
in the aggregate,  a Material Adverse Effect on Borrower,  Borrower shall,  upon
Lender's  request,  pay such amount as Lender  shall so have  determined  in its
reasonable


                                     - 12 -
<PAGE>


judgment  represents the value of such loss or depreciation in value. The making
of such payment shall not affect Lender's security interest in any Collateral.

     5.13 COMPUTER REPORTS.  Borrower irrevocably empowers Lender, upon Lender's
request,  to have full access to and to have, at Borrower's  expense,  printouts
and all information  maintained by its outside computer service company, if any,
respecting any and all financial records now or hereafter maintained by the same
on account of  Borrower.  If  Borrower  is  currently  using a service  company,
Borrower  agrees not to  terminate  the  present  arrangement  with any  service
company or acquire  any other  service  with any other such firm  without  prior
written  notification  to Lender.  If Borrower  does not currently use a service
company, Borrower shall notify Lender in writing at least ten (10) calendar days
in advance of entering into any agreement with or delivering any of its business
records to such service company.

     5.14 CHANGE IN LOCATION.  Borrower  shall notify  Lender in writing  thirty
(30) calendar  days in advance of the opening of any new place of business,  the
closing of any  existing  place of business or the  changing of any  location at
which Collateral is currently situated.

     5.15 CHANGE IN BUSINESS PRACTICES,  OFFICERS AND DIRECTORS.  Borrower shall
notify  Lender  of any  and  all  proposed  material  changes  in  its  business
practices,  properties and methods,  and of any proposed changes in the officers
and    directors    of   Borrower   or   of   any    Affiliate    of   Borrower.

     5.16  SALES  AGREEMENTS.  Borrower  shall  notify  Lender in writing of any
agreement under which any terms of sales (written or oral) different from normal
operating procedures may have been or will be granted.

     5.17  ADDITIONAL  TRADE  NAMES.  Borrower  shall give  Lender  thirty  (30)
calendar days advance  notice of the intention of Borrower to use any trade name
other than a trade name disclosed in Schedule  5.18.  Borrower shall execute any
and all documents  reasonably  required to perfect Lender's security interest in
said trade names.

     5.18  TENNESSEE  FINANCING  STATEMENT.  At Borrower's  request,  Lender has
agreed to limit the value of the Financing  Statements filed in Tennessee to One
Million Dollars  ($1,000,000.00),  based on Borrower's  representation as to the
aggregate  value of the Inventory  that will be located in Tennessee at any time
during the term of this Agreement;  provided,  that if at any time the aggregate
value of such  Inventory  is greater than One Million  Dollars  ($1,000,000.00),
Borrower  shall (i)  immediately  amend the applicable  Financing  Statements to
reflect the higher aggregate value of such Inventory and (ii) take all necessary
actions to ensure that Lender's  security  interest remains at all times a first
priority  perfected  security  interest in all of the Inventory  situated in the
State of Tennessee.


                                     - 13 -
<PAGE>


     5.19 VCOC QUALIFICATION.  So long as this Agreement or the Convertible Note
remain outstanding (or assuming  conversion of the Convertible Note, Lender owns
any  fully-diluted  voting  stock of the  Corporation),  such  investment  shall
qualify as a venture  capital  operation  company  under  applicable  ERISA laws
("VCOC").  The  Corporation  covenants  and agrees  Lender  shall  therefore  be
entitled to meet  periodically  with the  management of  Corporation on a timely
basis to discuss financial  results,  business  prospects and other matters upon
Lender's  reasonable  request and that Lender or its  designated  representative
shall be  afforded  free and full  access,  at all  reasonable  times,  and with
reasonable  prior  notice,  to all of the books,  records and  properties of the
Corporation  and to all officers,  employees and  accountants or auditors of the
Corporation and to make proposals to the Corporation,  the Board of Directors of
the Corporation and/or senior management of the Corporation.

                    SECTION 6 - BORROWER'S NEGATIVE COVENANTS

          Borrower hereby  covenants and agrees that, from and after the date of
this  Agreement  and so long as Borrower  shall be  indebted  to Lender,  unless
Lender  shall  consent  otherwise  in  writing,  it will comply with each of the
covenants in the Purchase Agreement,  which are hereby incorporated by reference
herein and made a part hereof, and, in addition, with the following covenants:

     6.1 INDEBTEDNESS.  Borrower shall not incur any Indebtedness other than the
obligations to Lender  represented by this Agreement and the  Convertible  Note.

     6.2  INVESTMENTS.  Borrower shall not purchase or acquire the  obligations,
securities or stock of, or any other additional interest in any Person,  except:
(i)  obligations  of  the US  Treasury,  US  federal  agencies  and  obligations
guaranteed  by the United  States of America or its  agencies;  (ii)  repurchase
agreements with major banks and authorized broker dealers,  fully collateralized
by US Treasury or US government agency securities; (iii) certificates of deposit
issued by major commercial banks having credit rating no lower that AA; and (iv)
commercial  paper rated no lower than A1/P1 of major  industrial  and  financial
corporations, shares of traditional money market funds for short term investment
of  uninvested  funds,  which  (x)  mature  within  365  days  from  the date of
acquisition thereof, and (y) are not in default as to principal or interest.

     6.3 DIVIDENDS AND PURCHASE OF STOCK.  Borrower shall not declare or pay any
dividend,  in cash or  otherwise,  on any  shares of any class of,  nor make any
distribution on account of, nor redeem,  retire,  purchase or otherwise  acquire
directly or indirectly, any of its capital stock.

     6.4   MISLEADING   STATEMENTS.   Borrower  shall  not  furnish  Lender  any
certificate  or other  document that  contains any untrue  statement of material
fact or that omits to state a material fact  necessary to make it not misleading
in light of the circumstances under which it was furnished.


                                     - 14 -
<PAGE>


     6.5  EVENT OF  DEFAULT.  Borrower  shall  not  suffer to exist any event of
default under any material  provision of any other financing  agreements binding
on it.

     6.6 SALE OF ACCOUNTS.  Borrower shall not sell, discount,  transfer, assign
or otherwise dispose of any of its Accounts,  notes  receivable,  installment or
conditional sales agreements or any other rights to receive income,  revenues or
money, however evidenced.

     6.7 LINE OF BUSINESS.  Borrower  shall not enter into any lines or areas of
business  substantially  different  from the business  activities in which it is
presently engaged.

     6.8  SUBSIDIARIES.  Borrower shall not create or acquire any  Subsidiaries;
provided,  however,  that Borrower is currently  evaluating whether to establish
two (2) separate  Delaware  Investment  Holding Companies through which Borrower
would  separately  hold and manage its  intellectual  property  and its cash and
liquid investment balances; and provided, further, that Borrower notifies Lender
at least thirty (30) calendar days prior to any such Investment  Holding Company
Subsidiary  being  created  and takes all steps  necessary  to  preserve  all of
Lender's rights in and to the Collateral.

     6.9 ADVANCES AND LOANS. Borrower shall not make any loan or advance or give
credit to any officer,  director or  shareholder of Borrower or of any Affiliate
of Borrower  or to any other  Person,  including  Subsidiaries  and  Affiliates.

     6.10  COMPENSATION  AND  FEES.  Borrower  shall  not pay  salary  or  other
compensation or fees, including but not limited to bonuses,  consulting fees and
management fees, to any officer, shareholder,  director or any Person, including
Subsidiaries and Affiliates,  except in reasonable  amounts for service actually
rendered.

     6.11 ERISA  COMPLIANCE.  Borrower  shall not (a) engage in any  "prohibited
transaction,"  as defined in Section 406 or Section  203(a) of ERISA,  incur any
"accumulated funding deficiency," as defined in Section 302 of ERISA, whether or
not waived,  or terminate any pension plan in a manner which could result in the
imposition  of a lien on the  property of Borrower  pursuant to Section  4068 of
ERISA, (b) "terminate," as that term is defined in ERISA, any multiemployer plan
to which Borrower or any trade or business (whether or not incorporated),  which
is under  common  control as defined in the  Internal  Revenue Code and of which
Borrower  is a part (a  "Commonly  Controlled  Entity"),  has an  obligation  to
contribute,  (c)  "withdraw,"  as that  term  is  defined  in  ERISA,  from  any
multiemployer  plan to which Borrower or any Commonly  Controlled  Entity has an
obligation to contribute,  or (d) "partially  withdraw," as that term is defined
in  ERISA,  from  any  multiemployer  plan to  which  Borrower  or any  Commonly
Controlled Entity has an obligation to contribute.


                                     - 15 -
<PAGE>


     6.12 TRANSFER OF  COLLATERAL.  Borrower  shall not transfer,  or permit the
transfer, to another location of any of the Collateral or of any Records related
to  any  of  the  Collateral   except  in  the  ordinary   course  of  business.

     6.13 SALE OF SUBSIDIARY STOCK. Borrower shall not transfer,  assign, pledge
or otherwise  dispose of shares of stock of any Subsidiary other than to Lender.

     6.14  PREPAYMENT.  Borrower  shall not prepay any  Indebtedness,  except as
contemplated in Section 2.3 of this Agreement.

     6.15  TRANSACTIONS.  Borrower  shall not enter  into any  transaction  that
could,  individually or in the aggregate,  have a Material Adverse Effect on the
Collateral or Borrower's ability to repay the Obligations.

                   SECTION 7 - REPRESENTATIONS AND WARRANTIES

          To  induce  Lender  to  enter  into  this  Agreement  and to make  the
Convertible Loan, Borrower hereby represents and warrants to Lender as follows:

     7.1 PURCHASE  AGREEMENT.  Borrower hereby  acknowledges and agrees that the
representations  and warranties set forth in Article 2 of the Purchase Agreement
are    incorporated   by   reference    herein   and   made   a   part   hereof.

     7.2 BINDING EFFECT.  This Agreement,  the Note and the other Loan Documents
delivered  pursuant hereto have been duly executed and delivered,  are valid and
legally  binding  obligations  of Borrower,  and are fully  enforceable  against
Borrower in accordance with their respective terms.

     7.3 TITLE TO ASSETS.  Borrower has good and marketable  title to all of its
assets,  subject to no security  interest,  encumbrance or lien, or claim of any
Person except for the Permitted Liens. The security interests granted in Section
4  hereof   constitute   valid  liens  subject  to  no  equal  or  prior  liens.

     7.4 CORPORATE AUTHORITY.  Borrower has the corporate power and authority to
execute,  deliver and perform this Agreement,  to borrow  hereunder and to incur
the Obligations,  and has taken all action necessary to authorize the execution,
delivery and performance of this Agreement,  the Notes and other Loan Documents.

     7.5  NO  VIOLATION.  The  execution,   delivery  and  performance  of  this
Agreement, the Notes and other Loan Documents will not immediately,  or with the
passage of time,  the giving of notice,  or both,  constitute a violation of any
applicable  law or of  Borrower's  articles  of  incorporation,  bylaws or other
incorporation  papers  or of  any  indenture,  agreement  undertaking  to  which
Borrower is a party or by which its properties  may be bound;  terminate or give
any Person


                                     - 16 -
<PAGE>


the right to terminate any contract,  agreement or instrument in which  Borrower
is a party or by which its properties may be bound; or result in the creation or
imposition of any security  interest in, or lien or encumbrance upon, any of the
assets of Borrower, except in favor of Lender.

     7.6 SOLVENCY.  Borrower is solvent, is able to pay its debts as they become
due and has capital  sufficient  to carry on its business and all  businesses in
which it is about to engage,  and now owns property  having a value both at fair
valuation and at present fair saleable value greater than the amount required to
pay Borrower's debts.  Borrower will not be rendered  insolvent by the execution
and delivery of this Agreement or by completion of the transactions contemplated
hereunder.

     7.7  COMMISSIONS.  Borrower has not made any  agreement or taken any action
which may cause anyone to become  entitled to a commission  or finder's fee as a
result of the making of the Convertible Loan.

     7.8  OTHER  CORPORATE  NAMES.  Borrower  has  not  used  any  corporate  or
fictitious name (including any trade name, trade style,  assumed name,  division
name or any similar  name),  other than the  corporate  name shown on Borrower's
certificate of incorporation.

     7.9 PLACES OF  BUSINESS.  Borrower's  principal  place of business  and all
other places of business  and/or  locations  where  inventory is situated at 301
South  State  Street,  Newtown,  PA 19940.  All the  Collateral  and the Records
pertaining to the Collateral are and will be located at the principal  places of
business of Borrower set forth hereinabove.

     7.10 LOANS TO OFFICERS. With the exception of that certain outstanding loan
to Mr. Robert Ashley,  in the amount of $56,195.00,  there is no outstanding and
unpaid  loans,  advances or  guaranties  to or for the benefit of any officer or
director of Borrower.

     7.11 NO  DEFAULTS.  There is no Event of Default as defined in Section  8.1
hereof and no event has occurred  and no condition  exists which upon the giving
of notice or the passage of time, or both, would constitute an Event of Default.

                               SECTION 8 - DEFAULT

8.1 EVENTS OF DEFAULT.  The occurrence of any one or more of the following shall
constitute an Event of Default hereunder:

          (A)  Borrower  shall  fail to pay when due,  on demand or at  maturity
(whether as stated or by acceleration) any payment of principal or interest,  or
any fee or charge, payable hereunder or under the Convertible Note.

          (B) Borrower  shall fail to observe or perform any  obligation,  other
than the  obligation  for payment of money  hereunder  or under the  Convertible
Note,  and such failure


                                     - 17 -
<PAGE>


shall  continue for 10 days after the earlier of: (1) the date written notice of
such  failure is mailed by Lender,  or (2) the date  Lender is  notified of such
failure or should have been so notified pursuant to the provisions hereof.

          (C)  Borrower  shall  fail to pay  any  Indebtedness  when  due to any
Person,  and such failure shall continue beyond any applicable grace period,  or
Borrower shall incur any other event of default under any agreement binding upon
it.

          (D) Any financial statement,  representation,  warranty or certificate
made or furnished by or on behalf of Borrower to Lender in connection  with this
Agreement,  the Purchase Agreement and the Stockholders and Registration  Rights
Agreement, or as an inducement to Lender to enter into this Agreement, or in any
separate  statement  or document to be delivered  hereunder to Lender,  shall be
materially false, incorrect, incomplete or misleading when made.

          (E)  Borrower  shall  admit  its  inability  to pay its  debts as they
mature, or shall make an assignment for the benefit of its creditors.

          (F) Proceedings in bankruptcy,  or for reorganization of Borrower,  or
for the readjustment of any of its debts,  under the Bankruptcy Code or any part
thereof,  or under any other laws,  whether state or federal,  for the relief of
debtors, now or hereafter existing,  shall be commenced by Borrower, or shall be
commenced  against  Borrower,  which  proceedings  against Borrower shall not be
discharged within sixty (60) calendar days of their commencement.

          (G) A receiver  or trustee  shall be  appointed  for  Borrower  or any
substantial part of its assets,  or any proceedings  shall be instituted for the
dissolution or the full or partial  liquidation of Borrower and such receiver or
trustee  shall  not  be  discharged  within  sixty  (60)  calendar  days  of his
appointment,  or such  proceedings  shall not be  discharged  within  sixty (60)
calendar days of their commencement,  or Borrower shall discontinue  business or
materially change the nature of its business.

          (H) Borrower  shall  suffer a final  judgment for the payment of money
and shall not  discharge  the same within a period of thirty (30)  calendar days
unless  execution  thereon  is  effectively  bonded  or stayed  pending  further
proceedings.

          (I) Any execution or attachment shall be levied against the Collateral
or any properties of Borrower, and such execution or attachment shall not be set
aside,  discharged  or stayed  within  thirty (30)  calendar days after the same
shall have been levied.

          (J) The validity or enforceability of this Agreement,  the Convertible
Note,  the  other  Loan  Documents   delivered  pursuant  hereto,  the  Purchase
Agreement, the Stockholders and Registration Rights Agreement or the Certificate
of Designation shall be


                                     - 18 -
<PAGE>


contested in any judicial forum by Borrower,  or Borrower shall deny that it has
any or further liability or obligation hereunder or thereunder.

          (K)  Any  material   adverse  change  shall  occur  in  the  condition
(financial  or  otherwise)  of  Borrower  or in the  quality or  quantity of the
Collateral.

          (L) Borrower  shall have  breached any of the  covenants or agreements
contained in this Agreement, the Convertible Note, the other Loan Documents, the
Purchase  Agreement or the Stockholders  and  Registration  Rights Agreement and
such  breach  shall not have been  cured to the  satisfaction  of Lender  within
thirty (30)  calendar  days after the date of giving of notice of such breach to
Borrower.

          (M) Any court of  competent  jurisdiction  shall  find that any of the
patents  owned or licensed by Borrower are invalid in any material  respect;  or
any of the patents  owned or licensed by Borrower  materially  infringe upon any
other patent;  provided,  however,  that in either event, Lender, in good faith,
determines  that such finding will have a Material  Adverse  Effect on Borrower.

          (N) At any time after the date of this Agreement, shares of Borrower's
Common Stock are not actively  publicly  traded on the American Stock  Exchange,
NASDAQ or NYSE.

          (O) Borrower  consolidates  or merges  Borrower with or into any other
corporation  or  corporations,   or  sells,   conveys  or  disposes  of  all  or
substantially  all of the assets of Borrower or a enters into a  transaction  or
series of related  transactions  in which more than fifty  percent  (50%) of the
voting power of Borrower is sold or otherwise disposed of.

             SECTION 9 - LENDER'S RIGHTS AND REMEDIES UPON DEFAULT.

9.1 ACCELERATION.  Upon the occurrence of an Event of Default, and in every such
event  and at any time  thereafter,  Lender  may,  at its  option,  declare  all
Obligations due and payable, without presentment,  demand, protest or any notice
of any kind, all of which are hereby expressly waived, anything contained herein
or in  any  of  the  other  Loan  Documents  to  the  contrary  notwithstanding.

     9.2  REMEDIES.  Lender  shall have,  in addition to the rights and remedies
given it by this Agreement, all those allowed by all applicable Laws, including,
without limitation, the Uniform Commercial Code of Commonwealth of Pennsylvania.

     Without limiting the generality of the foregoing, upon the occurrence of an
Event of Default,  Lender may immediately,  without demand or notice of any kind
to Borrower (except as specifically  required by this  Agreement),  all of which
are  hereby  expressly  waived,  and  without  advertisement,  sell at public or
private sale or otherwise realize upon the whole or, from time to


                                     - 19 -
<PAGE>


time,  any part of the  Collateral,  or any  interest  which  Borrower  may have
therein.  After deducting from the proceeds of sale or other  disposition of the
Collateral  all expenses  (including  all expenses for legal  services),  Lender
shall apply such proceeds toward the  satisfaction of the  Obligations,  in such
order as it  shall  determine  in its  sole  discretion.  Any  remainder  of the
proceeds after  satisfaction in full of the Obligations  shall be distributed as
required by applicable laws. At any such sale or other disposition,  Lender may,
to the extent permissible under applicable laws,  purchase the whole or any part
of the  Collateral,  free from any rights of redemption or  appraisement  on the
part of Borrower,  which rights are hereby  waived and  released.  Notice of any
sale or other disposition shall be given to Borrower at the address  hereinafter
set forth,  or such other  address of Borrower as may from time to time be shown
on Lender's  records,  at least five days before the time of any intended public
sale or the time after which any intended  private sale or other  disposition of
the Collateral is to be made,  which Borrower  hereby agrees shall be reasonable
notice of such sale or other  disposition.  Borrower  agrees to assemble,  or to
cause to be  assembled,  at its own  expense,  the  Collateral  at such place or
places as Lender shall designate.  Without limiting the generality of any of the
rights and remedies conferred upon Lender under this section, Lender may, to the
full extent permitted by applicable laws:

          (A) enter upon the premises of Borrower,  exclude and remove therefrom
all officers,  directors and employees of Borrower and take immediate possession
of the  Collateral,  either  personally  or through any agent,  or by means of a
receiver  appointed by a court of competent  jurisdiction,  using all  necessary
force to do so, which means shall be in Lender's sole discretion;

          (B)  at  Lender's  option,  use,  operate,   manage  and  control  the
Collateral in any lawful manner;

          (C)  collect,  receive  and  administer  all rents,  income,  revenue,
earnings, issues and profits (including the Accounts), and proceeds therefrom;

          (D) maintain, repair, renovate, alter or remove all or any part of the
Collateral, as Lender may determine in its sole discretion;

          (E) make exchanges,  substitutions or surrenders of all or any part of
the Collateral;

          (F) compromise, extend or renew any of the Collateral or deal with the
same as it may deem advisable;

          (G) notify postal  authorities  to change the address for the delivery
of mail to Borrower to such  address or post office box as Lender may  designate
and receive and open all mail addressed to Borrower;


                                     - 20 -
<PAGE>


          (H) remove from Borrower's  place of business all Records  relating to
or  evidencing  any of the  Collateral or without cost or expense to Lender make
such use of the Borrower's  place of business as may be reasonably  necessary to
administer, manage and collect the Collateral;

          (I) institute and prosecute legal and equitable proceedings to enforce
collection of the  Obligations of Borrower to Lender,  or to realize upon any of
the Collateral;

          (J) settle, renew, extend,  compromise,  compound,  exchange or adjust
claims in respect of any of the Collateral or any legal  proceedings  brought in
respect thereof;

          (K) subrogate to all of Borrower's  interests,  rights and remedies in
respect to the  Collateral,  including the right to stop delivery and to reclaim
Goods which the account debtor has returned,  rejected, revoked acceptance of or
failed to return, and which have been consigned or diverted,  to take possession
of and to sell or dispose of the Goods;

          (L) set off  and  apply  to all or any  part  of the  Obligations  all
moneys,  credits and other property of any nature  whatsoever of Borrower now or
any time  hereafter  in the  possession  of Lender or of any Person on behalf of
Lender,  in transit to or from Lender,  or under the control or custody of or on
deposit with Lender;

          (M) if Borrower shall fail to pay the Obligations or otherwise fail to
perform,  observe  or  comply  with  any of the  conditions,  covenants,  terms,
stipulations or agreements contained in this Agreement,  Lender,  without notice
to or  demand  upon  Borrower  and  without  waiving  or  releasing  any  of the
Obligations  or any Event of Default,  may (but shall be under no obligation to)
at any time thereafter make such payment or perform such act for the account and
at the expense of Borrower, and may enter upon the premises of Borrower for that
purpose and take all such action thereon as the Lender may consider necessary or
appropriate  for such  purpose.  All sums so paid or  advanced by Lender and all
costs and expenses (including, without limitation, attorneys' fees and expenses)
incurred in connection therewith,  together with interest thereon at the highest
interest rate charged on the Note from the date of payment, advance or incurring
until paid in full,  shall be paid by Borrower to Lender,  on demand,  and shall
constitute and become a part of the Obligations; and

          (N) such other and  further  acts and deeds in the name of Borrower as
Lender may deem necessary or advisable to the extent necessary for the Lender to
realize upon any of the Collateral.

     9.3  CONFESSION OF JUDGMENT.  Borrower  hereby  irrevocably  authorizes and
empowers any attorney of any court of record within the United States of America
or elsewhere to appear for Borrower and with or without  complaint  filed,  upon
the occurrence of an Event of Default, confess judgment or a series of judgments
in favor of Lender and against  Borrower for the 


                                     - 21 -
<PAGE>


Obligations to Lender  hereunder and all other amounts due Lender by Borrower as
evidenced  by an  affidavit  signed by an officer of Lender,  setting  forth the
amount then due,  plus costs of suit and an  attorneys'  commission of 5% of the
foregoing  sums,  but in no event  less than  $2,000.00,  on which  judgment  or
judgments one or more executions may issue forthwith; and for so doing, this, or
a copy hereof verified by affidavit,  shall be good and sufficient warrant;  and
the said judgment shall bear interest at the highest rate of interest charged on
the Note, or if lower, at the highest rate of interest a judgment may bear under
the  laws  of   Commonwealth  of   Pennsylvania.   Borrower  hereby  waives  and
relinquishes all errors, defects and imperfections in the entry and all benefits
under any law or rule of court  relating to a stay of execution or exempting any
property from any sale under execution.  The authority herein granted to confess
judgment shall not be exhausted by any exercise  thereof but shall continue from
time to time and at all times until the  Obligations to Lender have been paid in
full.

     9.4  ENFORCEMENT  AND WAIVER BY THE LENDER.  Lender shall have the right at
all  times  to  enforce  the  provisions  of this  Agreement  and the  documents
delivered  pursuant  hereto  in strict  accordance  with the  terms  hereof  and
thereof,  notwithstanding  any  conduct  or  custom  on the  part of  Lender  in
refraining from so doing at any time or times. The failure or delay of Lender at
any time or times to  enforce  its rights and  remedies  under such  provisions,
strictly in accordance with the same, shall not be construed as having created a
custom in any way or manner contrary to specific provisions of this Agreement or
as having in any way or manner  modified  or waived  the same.  All  rights  and
remedies of Lender are  cumulative  and  concurrent,  may be exercised by Lender
singly,  successively or together, or at such time or times and in such order of
preference  as the Lender may so  determine,  and the  exercise  of one right or
remedy by Lender shall not be deemed a waiver of any other right or remedy.

                           SECTION 10 - MISCELLANEOUS

10.1  CONSTRUCTION.  The  provisions of this  Agreement  shall be in addition to
those of any guaranty,  security agreement,  note or other evidence of liability
held by Lender,  all of which shall be construed as complementary to each other.
In the event of  ambiguity  or  inconsistency  between  this  Agreement  and any
agreement,  document  or  instrument  made  pursuant  hereto,  the terms of this
Agreement  shall govern.  Nothing  herein  contained  shall prevent  Lender from
enforcing  any  or  all  other  notes,  guarantees  or  security  agreements  in
accordance with their respective terms.

     10.2  FURTHER  ASSURANCE.  From time to time,  Borrower  will  execute  and
deliver to Lender such  additional  documents  and will provide such  additional
information  as Lender may  reasonably  require,  to carry out the terms of this
Agreement   and   to   be   informed   of   Borrower's   status   and   affairs.

     10.3 POWER TO EXECUTE  DOCUMENTS.  Borrower  hereby  irrevocably  appoints,
constitutes  and  names  Lender,  or any of its  officers,  the true and  lawful
attorney for Borrower, with full power of substitution to do the following, upon
the occurrence of an Event of Default:


                                     - 22 -
<PAGE>


          (A) to endorse the name of Borrower or any of  Borrower's  officers or
agents  upon  any  and  all  notes,  checks,   drafts,  money  orders  or  other
instruments, for the payment of moneys which are payable to Borrower, including,
without limitation,  proceeds under any policy of insurance on the Collateral or
constituting collections on Borrower's Accounts;

          (B) to sign and  endorse  the name of  Borrower  or any of  Borrower's
officers or agents upon any and all invoices, freight or express bills, bills of
lading,  storage or warehouse  receipts,  drafts against  debtors,  assignments,
verifications  and notices in connection  with accounts,  and any instruments or
documents relative thereto or to Borrower's rights therein;

          (C) to give written notice to postal authorities to effect such change
of address so that all mail  addressed to Borrower may be delivered  directly to
Lender or its designee; and

          (D) to do such  other  and  further  acts  and  deeds  in the  name of
Borrower as Lender may deem  necessary  or  desirable  to enforce any Account or
other Collateral for the Obligations.

     10.4 COSTS, EXPENSES AND FEES PAID AND PAYABLE TO LENDER.

          (A) Borrower  agrees to pay on demand all reasonable  attorneys'  fees
and  disbursements of counsel,  audit fees,  search fees,  filing fees and other
expenses  incurred by Lender in connection with the preparation,  administration
or  enforcement  of this  Agreement  or other Loan  Documents,  or any  renewal,
extension, amendment or modification of this Agreement and other Loan Documents,
and all such fees and expenses shall be a part of the Obligations  hereunder and
shall be paid at  Closing or at such later time as  services  are  performed  or
expenses incurred.

          (B) Borrower agrees that all costs, expenses and reasonable attorneys'
fees  incidental to the custody,  care,  management,  sale or collection  of, or
realization  upon,  any of the  Collateral  or in any way  relating to the care,
enforcement  or protection of the  Collateral or the  enforcement of any and all
rights of Lender either  hereunder or under any applicable law or custom,  shall
become  part of the  Obligations,  be payable on demand,  and be entitled to the
benefit of this  Agreement,  and Lender may at any time apply to the  payment of
all such costs and  expenses  all moneys of Borrower or other  proceeds  arising
from the possession or disposition of all or any portion of the Collateral.

     10.5  NOTICES.  Any  notices or  consents  required  or  permitted  by this
Agreement  shall be in writing and shall be deemed  delivered  if  delivered  in
person or if sent by certified mail, postage prepaid,  return receipt requested,
as  follows,  unless  such  address  is changed  by  written  notice  hereunder:

          (A) If to Lender:


                                     - 23 -
<PAGE>


                     OCM Principal Opportunities Fund, L.P.
                     c/o Oaktree Capital Management, LLC
                     333 South Grand Avenue, 28th Floor
                     Los Angeles, CA 90071
                     Attention:  Stephen Kaplan, Principal
                                 Michael Harmon, Vice President
                     Phone: 213-830-6300
                     Fax:   213-830-6395 

            with a required copy to:

                     Dechert Price & Rhoads
                     4000 Bell Atlantic Tower
                     1717 Arch Street
                     Philadelphia, PA  19103
                     Attention:  Donna E. Ostroff, Esq.
                     Phone: 215-994-4000
                     Fax:   215-994-2222 


            if to Borrower:

                     CollaGenex Pharmaceuticals, Inc.
                     301 South State St.
                     Newtown, PA 18940 
                     Attention:  Nancy Broadbent,
                                 Vice President and Chief Financial Officer
                     Phone: 215-579-7388
                     Fax:   215-579-8577

            with a required copy to:

                     Buchanan Ingersoll Professional Corporation
                     Princeton Forrestal Center
                     500 College Road East
                     Princeton, NJ 08540 
                     Attention:  David J. Sorin, Esq.
                     Phone: 609-987-6800
                     Fax:   609-520-0360


                                     - 24 -
<PAGE>


          Any change of address  for  purposes  of  notices  hereunder  shall be
deemed to have been given five days after mailing  thereof,  by certified  mail,
postage prepaid,  return receipt  requested,  to the other party at such party's
then effective address hereunder.

     10.6 WAIVER AND RELEASE BY THE BORROWER. To the maximum extent permitted by
applicable Laws, Borrower:

          (A) waives (1) demand, protest,  presentment and notice of dishonor of
all commercial  paper at any time held by Lender on which Borrower is in any way
liable;  and (2) notice and opportunity to be heard,  after  acceleration in the
manner  provided in Section  9.1,  before  exercise by Lender of the remedies of
self-help,  set-off or of other summary  procedures  permitted by any applicable
Laws or by any agreement with Borrower; and

          (B) releases Lender and its officers, partners,  attorneys, agents and
employees  from all claims for loss or damage  caused by any act or  omission on
the part of any of them in connection with or arising out of this Agreement, the
other Loan Documents,  any transactions  contemplated hereunder or thereunder or
the Collateral or otherwise, except for grossly negligent or reckless conduct.

     10.7 SURVIVAL OF REPRESENTATIONS  AND WARRANTIES.  All  representations and
warranties of Borrower  contained in this  Agreement will survive the making and
execution  of this  Agreement  and are  material and have been or will be relied
upon by  Lender,  notwithstanding  any  investigation  made by  Lender or by any
Person on its behalf. For purposes of the foregoing, all statements which are in
the nature of or which purport to be  representations  and  warranties and which
are contained in any  certificate  or other writing  required to be delivered or
which is delivered on or after the Closing by or on behalf of Borrower to Lender
pursuant to this Agreement or in connection with the  transactions  contemplated
hereby  shall  be  deemed  to be  representations  and  warranties  of  Borrower
contained in this Agreement.

     10.8  APPLICABLE  LAW.  The  substantive   laws  of  the   Commonwealth  of
Pennsylvania  shall govern the construction of this Agreement and the rights and
remedies of the parties  hereto,  without  regard to  principles of conflicts of
law.

     10.9  CONSENT TO  JURISDICTION  AND  SERVICE OF  PROCESS.  Borrower  hereby
irrevocably  appoints each and every  officer of Borrower as its attorneys  upon
whom may be served any notice,  process or pleading in any action or  proceeding
against it arising out of or in connection with this Agreement, the Notes or any
of the  Loan  Documents;  and  Borrower  hereby  consents  that  any  action  or
proceeding  against  it may be  commenced  and  maintained  in any court  within
Commonwealth  of  Pennsylvania  or in the United States  District  Court for the
Eastern District of Pennsylvania by service of process on any such officer;  and
Borrower  agrees that the courts of the  Commonwealth  of  Pennsylvania  and the
United States District Court for the Eastern District of Pennsylvania shall have
jurisdiction  with  respect  to the  subject  matter  hereof  and the  person of


                                     - 25 -
<PAGE>


Borrower.  Notwithstanding the foregoing,  Lender in its absolute discretion may
also  initiate  proceedings  in the  courts of any other  jurisdiction  in which
Borrower may be found or in which any of its assets or any of the Collateral may
be located.

     10.10 BINDING EFFECT, ASSIGNMENT AND ENTIRE AGREEMENT. This Agreement shall
inure to the  benefit  of,  and shall be binding  upon,  the  respective  heirs,
executors,  administrators,  successors  and  permitted  assigns of the  parties
hereto.  Borrower  shall not assign any of its rights or  obligations  hereunder
without the prior written consent of Lender. This Agreement, the Note, the other
Loan Documents and any other documents  executed and delivered  pursuant hereto,
constitute  the entire  agreement  between the  parties,  superseding  all prior
agreements relating to the subject matter hereof.

     10.11  MODIFICATIONS.  No  modification  or waiver of any provision of this
Agreement or of the Notes,  nor consent to any departure by Borrower  therefrom,
shall in any event be  effective  unless the same shall be in writing,  and then
such waiver or consent shall be effective only in the specific  instance and for
the  purpose  for which  given.  No notice to or demand on  Borrower in any case
shall  entitle  Borrower  to any other or  future  notice or demand in the same,
similar or other circumstance.

     10.12  SEVERABILITY.  If any  provision  of this  Agreement  shall  be held
invalid under any  applicable  law, such  invalidity  shall not affect any other
provision  of this  Agreement  which can be given  effect  without  the  invalid
provision.    To   this   end,   the    provisions    hereof   are    severable.

     10.13 NO  RESPONSIBILITY  OF LENDER;  INDEMNIFICATION.  Lender shall not be
deemed to have assumed any liability or responsibility to Borrower or any Person
for the  correctness,  validity or genuineness  of any  instruments or documents
that  may  be  released  or  endorsed  to  Borrower  by  Lender   (which   shall
automatically be deemed to be without  recourse to Lender in any event),  or for
the existence, character, quantity, quality, condition, value or delivery of any
Goods  purporting  to be  represented  by any such  documents;  and  Lender,  by
accepting  such  security  interest in the  Collateral  or by releasing any such
Collateral  to Borrower,  shall not be deemed to have assumed any  obligation or
liability to any supplier or account debtor or to any other Person, and Borrower
agrees to  indemnify  and defend  Lender and hold it  harmless in respect to any
claim or  proceeding  arising out of any matter  referred to in this  Subsection
10.13.

     10.14  COUNTERPARTS.  This  Agreement  may be  executed  in any  number  of
counterparts,  each of which shall be deemed to be an original, but all of which
together shall constitute one and the same instrument.

     10.15 HEADINGS. The headings in this Agreement are for convenience only and
shall not limit or otherwise affect any of the terms hereof.


                                     - 26 -
<PAGE>


     10.16  WAIVER OF TRIAL BY JURY.  Borrower and Lender waive trial by jury in
any  suit or  proceeding  brought  in  connection  with  this  Agreement  or the
transactions contemplated hereunder.

     10.17  EXHIBITS  AND  SCHEDULES.  This  Agreement  includes  the  following
Exhibits and Schedules, which are attached hereto and incorporated into and made
a part of this Agreement:

     Exhibit A                Convertible Note

     Exhibit B                Special Power of  Attorney

     Exhibit C-1              Opinion of Borrower's  Counsel

     Exhibit C-2              Opinion of Borrower's  Patent Counsel 

     Exhibit D                Security  Agreement

     Schedule 5.7             Financing Statement Jurisdictions

     Schedule 5.18            Trade Names

     10.18 ADVICE OF COUNSEL.  Borrower acknowledges that it has been advised by
its counsel  with respect to this  transaction  and this  Agreement,  including,
without limitation, any waivers contained herein.


                                     - 27 -
<PAGE>


          IN WITNESS WHEREOF, the undersigned have executed this Agreement as of
the day and year first above written.




                          COLLAGENEX PHARMACEUTICALS, INC.

                          By:/s/ Brian M. Gallagher
                             ------------------------------------------
                          Name:   Brian M. Gallagher
                          Title:  President and Chief Executive Officer



                          By:/s/ Nancy C. Broadbent
                             ------------------------------------------
                          Name:   Nancy C. Broadbent
                          Title:  Vice President and Chief Financial Officer

                          OAKTREE PRINCIPAL OPPORTUNITIES FUND, L.P.

                          By:  Oaktree Capital Management, LLC,
                               its general partner

                               By:/s/ Stephen Kaplan
                                  -------------------------------------
                               Name:  Stephen Kaplan
                               Title: Principal


                               By:/s/ Michael Harmon
                                  -------------------------------------
                               Name:  Michael Harmon
                               Title: Vice President




                                     - 28 -





                                CONVERTIBLE NOTE

THE SHARES ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED  UNDER
THE SECURITIES ACT OF 1933 OR UNDER ANY STATE  SECURITIES  LAWS. THEY MAY NOT BE
SOLD OR OFFERED FOR SALE IN THE ABSENCE OF AN EFFECTIVE  REGISTRATION  STATEMENT
AS TO THE SECURITIES  UNDER SAID ACT AND ANY APPLICABLE  STATE SECURITIES LAW OR
AN OPINION OF COUNSEL  SATISFACTORY TO THE CORPORATION THAT SUCH REGISTRATION IS
NOT REQUIRED.

                        COLLAGENEX PHARMACEUTICALS, INC.

             12 % SENIOR SECURED CONVERTIBLE NOTE DUE March 18, 2000


No. 1                                                             $10,000,000.00


          COLLAGENEX   PHARMACEUTICALS,   INC.,  a  Delaware   corporation  (the
"Corporation," which term includes any successor corporation),  with a principal
office  at 301  South  State  Street,  Newtown,  Pennsylvania  18940,  for value
received  promises  to pay to OCM  PRINCIPAL  OPPORTUNITIES  FUND,  L.P.  or its
permitted assignees ("Holder"),  the principal sum of US Ten Million Dollars (US
$10,000,000.00)  on March 18, 2000 and to pay  interest on the unpaid  principal
amount of this Note at the rate of Twelve  Percent  (12%) per annum  during  the
period  commencing on the date hereof and thereafter.  The Corporation  will pay
interest  quarterly in arrears on June 30,  September 30, December 31, and March
31 of each year, commencing on September 1, 1999 (the "Interest Payment Dates").
Interest on this Note will  accrue  from the most recent date to which  interest
has been paid or, if no interest has been paid,  from the date hereof.  Interest
will be  computed on the basis of a 360-day  year of twelve (12) 30-day  months.
This Note  cannot be prepaid at any time,  except for the  mandatory  prepayment
referred to herein.

          This Note is a duly authorized and legally  binding  instrument of the
Corporation,  and was  issued  to the  Holder of this  Note  (together  with its
permitted assignees and transferees,  the "Holders") pursuant to the Convertible
Loan  and  Security  Agreement  dated  the  date  hereof,  by  and  between  the
Corporation and Holder ("Agreement").

          This  Note  is  that  certain  Convertible  Note  referred  to in  the
Agreement,  and  shall  evidence  the  Corporation's  obligation  to  repay  the
Convertible Loan, as defined in the Agreement.  If the Corporation fails to make
any payment required hereunder or if an Event of Default occurs or is continuing
under the Agreement, Lender may declare the Corporation in default hereunder and
may declare the unpaid principal balance of this Note, including any accrued but
unpaid  interest  thereon,  to be  immediately  due and  payable.  Holder  shall
thereupon  have the option,  at any time and from time to time,  to exercise all
rights and remedies set forth herein or in the Agreement,  as well as all rights
and  remedies  otherwise  available to Holder at law or in equity to collect the
unpaid  indebtedness  evidenced hereby.  Any capitalized term used


<PAGE>


in this Note, and not otherwise defined herein,  shall have the meaning ascribed
to such term in the Agreement.

     Section 1.   Method of Payment.
     ------------------------------

          (a) METHOD OF PAYMENT.  The Corporation will pay interest on this Note
to the person who is the registered Holder of this Note at the close of business
on June 30,  September  30,  December 31, and March 31 of each year,  or if such
date is not a banking  day then the next  banking  day  preceding  the  Interest
Payment Date.  The  Corporation  will pay principal and interest in money of the
United  States that at the time of payment is legal tender for payment of public
and private debts, by confirmed wire transfer of immediately  available funds to
an account designated by Holder. If a payment date is a Saturday,  a Sunday or a
legal  holiday at a place of  payment,  payment may be made at that place on the
immediately  preceding day that is not a Saturday,  a Sunday or a legal holiday,
and no interest shall accrue for the intervening period.

          (b) NO  PREPAYMENTS.  Except as expressly set forth in Section 1(c) of
this Note, under no  circumstances  shall the Corporation be permitted to prepay
this Note.

          (c) MANDATORY  PREPAYMENT.  In the event that Holder  consummates  the
purchase  of  shares  of  the  Corporation's  Series  D  Cumulative  Convertible
Preferred  Stock (the  "Purchase  Transaction"),  as  contemplated  in the Stock
Purchase Agreement of even date herewith, by and among the Corporation,  Holder,
and the Persons named therein,  the Corporation  shall prepay this Note in full,
out of the proceeds of the Purchase Transaction.

     Section 2.   Affirmative Covenants.
     ----------------------------------

          (a) PAYMENT.  The Corporation  shall pay the principal of and interest
on the  Note  on the  dates  and  in the  manner  provided  in  this  Note.  The
Corporation   shall  pay  interest   (including   interest  accruing  after  the
commencement  of any  bankruptcy,  insolvency or  reorganization  proceeding) on
overdue principal of the Note at the rate borne by the Note.

          (b)  PRESERVATION OF CORPORATE  EXISTENCE;  ETC. Subject to Section 8,
the Corporation will do or cause to be done all things necessary to preserve and
keep in full force and effect its  corporate  existence  and that of each of its
subsidiaries  and the material  rights (charter and statutory) and franchises of
the Corporation.

          (c) LAWS. The  Corporation  will comply in all material  respects with
all material applicable  statutes,  regulations,  orders and restrictions of the
United States, any state,  municipality or other governmental  division thereof,
and agencies and  instrumentalities of the foregoing,  in respect of the conduct
of  its  business  and  the  ownership  of  its  property  (including,   without
limitation,  applicable statutes,  regulations, orders and restrictions relating
to equal employment  opportunities  and  environmental  standards and controls),
except such as are being contested in good faith, or if the failure so to comply
could not  reasonably  be  expected  to have a  material  adverse  effect on the
financial condition of the Corporation and its subsidiaries taken as a whole.


                                        2
<PAGE>


          (d)  FINANCIAL  STATEMENTS.  The  Corporation  will furnish  financial
statements and other reports to Holder in accordance with the Agreement.

          (e) OTHER  COVENANTS.  In addition to the  covenants set forth in this
Note,  the  Corporation  shall comply with all of the covenants set forth in the
Agreement.

     Section 3.   Conversion of Note.
     -------------------------------

          (a) Subject to and upon  compliance  with this Section 3, Holder shall
have the right, at its option,  at any time or from time to time, after June 30,
1999, to convert,  in whole or in part, the unpaid principal  amount hereof,  in
whole or in part (the  "Conversion  Amount"),  into  registered,  fully paid and
non-assessable  shares of the  Corporation's  common  stock,  par value $.01 per
share (the "Common Stock") One Million Five Hundred  Thirty-Eight  Thousand Four
Hundred Sixty-Two  (1,538,462)  shares of Common Stock. Such conversion shall be
effected at the "Note  Conversion  Price" of $6.50 per share.  In addition,  any
accrued and unpaid  interest as of the Date of  Conversion  (as defined below in
Section 3(b) hereof) shall be convertible into additional shares of Common Stock
at the same Note Conversion Price.

          (b) In order to exercise the conversion right,  Holder shall surrender
this Note during regular business hours at the office of the Corporation  stated
above,  accompanied  by written  notice to the  Corporation  at said office that
Holder elects to convert this Note and shall specify the Conversion Amount. Such
notice  shall  also  state  the  name or  names  (with  address)  in  which  the
certificate or  certificates  for shares of Common Stock  deliverable  upon such
conversion  shall be issued.  This Note, upon surrender for  conversion,  shall,
unless the shares  deliverable  upon  conversion are to be delivered in the same
name as Holder, be accompanied by proper  assignments for transfer.  As promptly
as practicable  after the receipt of such notice and the surrender of this Note,
but  subject to  Section  3(c),  the  Corporation  shall  deliver or cause to be
delivered to Holder a certificate or certificates  for the number of registered,
fully paid and non-assessable shares of Common Stock deliverable upon conversion
of this Note in the Conversion Amount pursuant to Holder's notice of conversion.
Certificates  evidencing the shares of Common Stock delivered upon conversion of
this Note shall bear a legend (to the extent  applicable)  similar to the legend
on the face of this Note. Such conversion  shall be deemed to have been effected
immediately  prior to the close of  business  on the date on which  such  notice
shall  have been  received  by the  Corporation  and this Note  shall  have been
surrendered  (the "Date of  Conversion"),  and at such time the rights of Holder
shall cease with respect to the  Conversion  Amount  converted and the person or
persons in whose name or names any  certificate  or  certificates  for shares of
Common  Stock shall be  issuable  upon such  conversion  shall be deemed to have
become the holder or holders of record of the shares represented  thereby unless
the stock  transfer  books of the  Corporation  shall be closed on that date, in
which event such person or persons shall be deemed to have become such holder or
holders of record on the next  succeeding day on which such stock transfer books
are open, but in any event such conversion shall be at the Note Conversion Price
in effect on the Date of Conversion.  No adjustment  shall be made for dividends
on any Common Stock that shall be delivered upon the conversion of such Note.


                                        3
<PAGE>


          (c) No fractional shares shall be issued upon conversion of this Note,
and the number of shares of Common Stock to be issued shall be rounded upward to
the nearest whole share, and there shall be no payment to Holder. Whether or not
fractional  shares result from such conversion  shall be determined on the basis
of the Conversion  Amount Holder is at the time converting into Common Stock and
the number of shares of  Common Stock issuable upon such aggregate conversion of
this Note.

          (d) In the  event  the  Corporation  at any time or from  time to time
after the date of issuance of this Note fixes a record date for the effectuation
of a split or  subdivision  of the  outstanding  shares of Common Stock  without
payment of any  consideration by such holder for the additional shares of Common
Stock then, as of such record date (or the date of such split or  subdivision if
no record  date is fixed),  the Note  Conversion  Price  shall be  appropriately
decreased so that the number of shares of Common Stock issuable on conversion of
the Note shall be  increased in  proportion  to such  increase in the  aggregate
number of shares issuable of Common Stock.

          (e) In the event that the Corporation  shall issue Additional Stock to
holders of its  outstanding  Common  Stock,  without any charge to such holders,
entitling  them to  subscribe  for or purchase  shares of its Common  Stock at a
price per share that is lower at the record date for such issuance than the Note
Conversion Price, then the Note Conversion Price in effect  immediately prior to
each (such issuance or deemed  issuance) shall be adjusted to a price determined
by the  following  formula:  (A + B) / (C + D),  where "A"  equals the number of
shares of Common Stock  outstanding  immediately  prior to such issuance or sale
multiplied by the then applicable Note  Conversion  Price,  where "B" equals the
consideration,  if any,  received by the Corporation upon such issuance or sale,
where "C" equals the total number of shares of Common Stock outstanding prior to
issuance of the additional  shares and where "D" equals any additional  stock or
conversion  shares,  or  any  other  shares  reserved  for  issuance  which  are
associated  with such financing,  immediately  after such issuance or sale. Such
adjustment  shall  become  effective at the close of business on the record date
for the determination of stockholders  entitled to receive such rights,  options
or warrants.

               (i)  "Additional  Stock" shall mean any shares of Common Stock or
               shares  of  Common  Stock   issuable   pursuant  to   Convertible
               Securities  issued or  Options  (or  deemed  to have been  issued
               pursuant to Section  3(i)  hereof) by the  Corporation  after the
               date of issuance of this Note, except:

                  (A) Common Stock issued pursuant to a transaction described in
                  Sections 3(d) hereof;

                  (B) Common  Stock or options to  purchase  such  Common  Stock
                  issued to officers,  employees or directors of, or consultants
                  to,  the  Corporation,  pursuant  to any  agreement,  plan  or
                  arrangement   approved  by  the  Board  of  Directors  of  the
                  Corporation;  provided,  however,  that the maximum  number of
                  shares of  Common  Stock  heretofore  or  hereafter  issued or
                  issuable   pursuant   to  all  such   agreements,   plans  and
                  arrangements  shall not


                                        4
<PAGE>


                  exceed an aggregate (as constituted on the date hereof) of Two
                  Million  Three  Hundred  Two  Thousand  (2,302,000)  shares of
                  Common Stock ("Permitted Options"); and

                  (C) Common Stock issued or issuable  upon  conversion  of this
                  Note.

          (f) No  adjustment  of the Note  Conversion  Price shall be made in an
amount less than  one-half of One Cent  ($0.005)  per share,  provided  that any
adjustments  which are not required to be made by reason of this sentence  shall
be carried forward and shall be taken into account in any subsequent  adjustment
to the  Note  Conversion  Price.  No  adjustment  of the Note  Conversion  Price
pursuant  to this  Section  3(f) shall have the  effect of  increasing  the Note
Conversion Price in effect immediately prior to such adjustment.

          (g) In the case of the issuance of securities of the  Corporation  for
cash,  the  amount  of  consideration  received  by  the  Corporation  for  such
securities  shall be  deemed  to be the  amount  of cash  paid  therefor  before
deducting any discounts, commissions or other expenses allowed, paid or incurred
by the  Corporation  for any  underwriting  or otherwise in connection  with the
issuance and sale thereof.

          (h) In the case of the issuance of securities of the Corporation for a
consideration in whole or in part other than cash, the consideration  other than
cash shall be deemed to have a dollar  value equal to the fair  market  value of
such non-cash  consideration,  irrespective of any accounting treatment thereof,
as determined by a vote of the majority of the Board of Directors.

          (i) In the case of the issuance  (whether before, on or after the date
of issuance of this Note) of Options or  Convertible  Securities,  the following
provisions shall apply for all purposes of this Section 3(e) and Section 3(e)(i)
hereof:

               (A)  With  respect to  Options  to  purchase  Common  Stock,  the
                    aggregate   maximum   number  of  shares  of  Common   Stock
                    deliverable upon exercise of such Options shall be deemed to
                    have been  issued at the time such  Options  were issued and
                    for a consideration  equal to the consideration  (determined
                    in the manner  provided  in Section  3(g) and  Section  3(h)
                    hereof),  if  any,  received  by the  Corporation  for  such
                    Options  plus the minimum  exercise  price  provided in such
                    Options for Common Stock issuable thereunder.

               (B)  With  respect  to  Convertible  Securities  and  Options  to
                    purchase  Convertible  Securities,   the  aggregate  maximum
                    number  of  shares  of  Common  Stock  deliverable  upon the
                    conversion  or exchange of any such  Convertible  Securities
                    and the aggregate  maximum  number of shares of Common Stock
                    issuable  upon the  exercise  of such  Options  to  purchase
                    Convertible  Securities  and the  subsequent  conversion  or
                    exchange of such  Convertible  Securities


                                       5
<PAGE>


                    shall  be  deemed  to have  been  issued  at the  time  such
                    Convertible Securities or such Options were issued and for a
                    consideration  equal to the consideration,  if any, received
                    by the Corporation for any such  Convertible  Securities and
                    Options, plus the minimum additional consideration,  if any,
                    to be received by the  Corporation  upon the  conversion  or
                    exchange of such  Convertible  Securities or the exercise of
                    such  Options  and  the   conversion   or  exchange  of  the
                    Convertible   Securities  issuable  upon  exercise  of  such
                    Options (the  consideration in each case to be determined in
                    the  manner  provided  in  Section  3(g)  and  Section  3(b)
                    hereof).

               (C)  In the event of any change in the number of shares of Common
                    Stock  deliverable,  or in the consideration  payable to the
                    Corporation,   upon   exercise  of  such   Options  or  upon
                    conversion  or  exchange  of  such  Convertible  Securities,
                    including,  but not limited to, a change  resulting from the
                    anti-dilution provisions thereof, the Note Conversion Price,
                    to the extent in any way affected by or computed  using such
                    Options or  Convertible  Securities,  shall be recomputed to
                    reflect such change, but no further adjustment shall be made
                    for the actual  issuance  of Common  Stock or any payment of
                    such  consideration upon the exercise of any such Options or
                    the conversion or exchange of such Convertible Securities.

               (D)  Upon the  expiration or  termination  of any such Options or
                    any  such   rights  to  convert  or   exchange   Convertible
                    Securities,  the Note Conversion Price, to the extent in any
                    way   affected  by  or  computed   using  such   Options  or
                    Convertible  Securities,  shall be recomputed to reflect the
                    issuance  of only the number of shares of Common  Stock (and
                    Options and Convertible  Securities  which remain in effect)
                    that were actually  issued upon the exercise of such Options
                    or upon  the  conversion  or  exchange  of such  Convertible
                    Securities.

               (E)  The number of shares of Common Stock  deemed  issued and the
                    consideration  deemed  paid  therefor  pursuant  to Sections
                    3(i)(A) and (B) hereof  shall be  appropriately  adjusted to
                    reflect any change,  termination  or  expiration of the type
                    described in either Sections 3(i)(C) or (D) hereof.

          (j)  If  at  any  time  or  from  time  to  time  there   shall  be  a
recapitalization or reclassification of Common Stock, provision shall be made so
that the Holder of this Note shall  thereafter  be  entitled  to  receive,  upon
conversion  of this Note,  the number of shares of stock or other  securities or
property of the Corporation or otherwise,  receivable upon such recapitalization
or  reclassification  by a holder of the  number of shares of Common  Stock into
which  this  Note  could  have  been   converted   immediately   prior  to  such
recapitalization.  In any such case, appropriate adjustment shall be made in the
application  of the  provisions  of this Section 3 with


                                       6
<PAGE>


respect to the rights of the Holders of this Note after the  recapitalization or
reclassification  to the end that the  provisions of this Section 3.  (including
adjustments of the Note Conversion Price then in effect and the number of shares
purchasable  upon conversion of this Note) shall be applicable  after that event
as nearly  equivalent as may be  practicable.

          (k) In the event the Corporation shall declare a distribution  payable
in  securities  of  other  persons,  evidences  of  indebtedness  issued  by the
Corporation or other persons,  assets  (excluding  cash dividends) or options or
rights not referred to in Section 3(d) hereof,  then,  in each such case for the
purpose of this  Section  3(k),  the Holders of this Note shall be entitled to a
proportionate  share of any such  distribution  as though  such  Holder  was the
holder  of the  number  of  shares  of  Common  Stock  into  which  this Note is
convertible as of the record date fixed for the  determination of the holders of
shares of Common Stock entitled to receive such distribution.

          (l) Before taking any action which would cause an adjustment  reducing
the Conversion  Price below the then par value,  if any, of the shares of Common
Stock issuable upon the conversion of this Note, the  Corporation  will take any
corporate action which may, in the opinion of its counsel, be necessary in order
that the  Corporation may validly and legally issue  registered,  fully paid and
non-assessable shares of the Common Stock at such adjusted Conversion Price.

          (m) Upon the occurrence of each adjustment or readjustment of the Note
Conversion  Price  pursuant to this Section 3 the  Corporation,  at its expense,
shall promptly  compute such  adjustment or  readjustment in accordance with the
terms hereof and prepare and furnish to Holder a certificate  setting forth such
adjustment  or  readjustment  and  showing  in detail  the facts upon which such
adjustment or readjustment is based, certified by the Corporation's President or
Chief Financial Officer.  The Corporation shall, upon the written request at any
time  of  Holder,  furnish  or  cause  to be  furnished  to such  Holder  a like
certificate  setting forth (i) such adjustment and  readjustment,  (ii) the Note
Conversion Price at the time in effect, and (iii) the number of shares of Common
Stock and the  amount,  if any,  of other  property  which at the time  would be
received upon the conversion of this Note.

          (n) The  Corporation  covenants  that it will at all times reserve and
keep  available out of its  authorized  Common Stock,  solely for the purpose of
delivery upon  conversion of this Note as herein  provided such number of shares
of Common Stock as shall then be deliverable  upon the conversion of the maximum
amount of principal and accrued but unpaid interest convertible pursuant to this
Note. The Corporation  covenants that all the shares of Common Stock which shall
be so deliverable upon conversion of this Note shall be duly and validly issued,
registered, fully paid and non-assessable.

          (o) The delivery of  certificates  for shares of Common Stock upon the
conversion  of this  Note  shall  be  made  without  charge  to  Holder  for any
documentary,  stamp or similar  issue or transfer tax in respect of the issuance
of such  certificates,  and such certificates shall be delivered in the name of,
or in such  names as may be  directed  by  Holder.  The  Corporation  shall not,
however,  be  required  to pay any tax which may be  payable  in  respect of any
transfer  involved  in the issue or  transfer  and  delivery of shares of Common
Stock in a name


                                       7
<PAGE>


other than that of Holder and no such issue or transfer  and  delivery  shall be
made  unless  and until the  person  requesting  such  transfer  has paid to the
Corporation the amount of any such tax or has established to the satisfaction of
the Corporation that such tax has been paid.

          (p) If the  Common  Stock of the  Corporation  ceases  to be listed or
authorized to be quoted on any national securities exchange or the public market
for  the  Common  Stock  of the  Corporation  otherwise  ceases  to  exist,  the
Corporation  shall  engage an  investment  bank,  reasonably  acceptable  to the
Corporation  and Holder,  to determine the fair market value price of the Common
Stock, from time to time in connection with this Note.

          (q) In the event of any taking by the  Corporation  of a record of the
holders of any class of securities  for the purpose of  determining  the holders
thereof  who are  entitled to receive any right to  subscribe  for,  purchase or
otherwise  acquire any shares of stock of any class or any other  securities  or
property,  or to receive any other right, the Corporation  shall mail to Holder,
at least twenty (20) calendar days prior to the date specified therein, a notice
specifying  the date on which any such  record is to be taken for the purpose of
such right, and the amount and character of such right.

          (r) The  Corporation  will not, by  amendment  of its  Certificate  of
Incorporation  or  through  any  reorganization,  recapitalization  or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation,  but will at
all times in good faith assist in the carrying out of all the provisions of this
Section  3.  and in the  taking  of  all  such  action  as may be  necessary  or
appropriate  in order to protect  the  conversion  rights of Holder of this Note
against impairment.

          (s) Shares of the Corporation's  Common Stock issuable upon conversion
of this Note,  shall be  subject to the terms and  conditions  and  entitled  to
receive the benefits of the Stockholders and Registration Rights Agreement.

          (t)  "Closing  Market  Price"  for any day means  the last sale  price
regular  way,  or, in case no such sale takes place on such day,  the average of
the  closing  bid and asked  prices  regular  way, in either case as reported on
American Stock Exchange,  National  Association of Securities  Dealers Automated
Quotation System, or New York Stock Exchange.

          (u) "Convertible Securities" means any indebtedness or shares of stock
convertible into or exchangeable for Common Stock.

          (v)  "Option"  means  rights,  options or warrants to  subscribe  for,
purchase or otherwise acquire Common Stock or Convertible Securities.

     Section 4.   Seniority.
     -----------------------

          This Note and the  obligations  evidenced  hereby shall rank senior in
priority to any other obligations or indebtedness of the Corporation.

     Section 5.   Events of Default.
     -------------------------------


                                       8
<PAGE>


          (a) An "Event of Default" occurs if:

               (i) the  Corporation  shall fail to pay when due, on demand or at
               maturity  (whether as stated or by  acceleration)  any payment of
               principal or interest, or any fee or charge, payable hereunder or
               under the Agreement.

               (ii)  the  Corporation  shall  fail to  observe  or  perform  any
               obligation,  other  than  the  obligation  for  payment  of money
               hereunder or under the Agreement or shall  materially  breach any
               of  the  covenants  or  agreements   contained   herein,  in  the
               Agreement,  the other Loan Documents,  the Purchase  Agreement or
               the  Stockholders  and Registration  Rights  Agreement,  and such
               failure or breach  shall  continue for thirty (30) days after the
               earlier of: (1) the date written notice of such failure is mailed
               by Holder,  or (2) the date Holder is notified of such failure or
               should have been so notified pursuant to the provisions hereof.

               (iii) the Corporation shall fail to pay any Indebtedness when due
               to any  Person,  and  such  failure  shall  continue  beyond  any
               applicable grace period, or the Corporation shall incur any other
               event of default under any agreement binding upon it.

               (iv) the  Corporation  shall admit its inability to pay its debts
               as they mature,  or shall make an  assignment  for the benefit of
               its   creditors;   or   proceedings   in   bankruptcy,   or   for
               reorganization of the Corporation, or for the readjustment of any
               of its debts,  under the Bankruptcy Code or any part thereof,  or
               under any other laws, whether state or federal, for the relief of
               debtors,  now or  hereafter  existing,  shall be commenced by the
               Corporation, or shall be commenced against the Corporation, which
               proceedings  against  the  Corporation  shall  not be  discharged
               within  sixty  (60)  calendar  days of their  commencement;  or a
               receiver or trustee shall be appointed for the Corporation or any
               substantial  part of its  assets,  or any  proceedings  shall  be
               instituted for the dissolution or the full or partial liquidation
               of the  Corporation  and such  receiver  or trustee  shall not be
               discharged within sixty (60) calendar days of his appointment, or
               such  proceedings  shall  not be  discharged  within  sixty  (60)
               calendar days of their  commencement,  or the  Corporation  shall
               discontinue  business  or  materially  change  the  nature of its
               business.

          (b) If an Event of Default  (other than an Event of Default  specified
in  Section  5(a)(iv))  occurs  and is  continuing,  then and in every such case
Holder may declare the principal of and accrued  interest and unpaid on the Note
to be due and payable  immediately by a notice in writing to the Corporation and
upon any such  declaration  such  principal and any accrued but unpaid  interest
shall become  immediately due and payable.  If an Event of Default  specified in
Section 5(a)(iv) occurs and is continuing, the principal of and accrued interest
and unpaid  interest on the Note shall ipso facto become and be immediately  due
and payable without any declaration or other act on the part of Holder.  Subject
to  Sections  5(c) and 6,  Holder,  by  notice to the  Corporation,  may waive a
default or Event of Default and its consequences.

          (c)  Subject to Section 4, the right of Holder of this Note to receive
payment of  principal  of and  interest on this Note,  on or after the due dates
expressed herein, or to bring suit


                                       9
<PAGE>


for the  enforcement  of any such  payment on or after  such date,  shall not be
impaired or affected without the consent of Holder of this Note.

     Section 6.   Amendment and Waiver.
     ----------------------------------

          This Note may be amended only with express  prior  written  consent of
Holder, and any past default or compliance with any provision may be waived in a
particular instance only with such consent of Holder.

     Section 7.   No Merger, etc.
     ----------------------------

          So  long  as  this  Note  or the  Agreement  remain  outstanding,  the
Corporation shall not consolidate with or merge into any other person or convey,
transfer or lease its properties and assets  substantially as an entirety to any
person,  and the Corporation  shall not permit any person to consolidate with or
merge into the  Corporation  or convey,  transfer  or lease its  properties  and
assets substantially as an entirety to the Corporation.

     Section 8.   Denominations; Transfer and Exchange.
     --------------------------------------------------

          This Note may be  transferred  or  assigned,  in whole or in part,  by
Holder.  When the Note is presented or surrendered for  registration of transfer
or exchange, it shall be duly endorsed or be accompanied by a written instrument
of transfer in form reasonably  satisfactory to the Corporation duly executed by
Holder thereof or its attorney duly authorized in writing. The Corporation shall
bear all costs and expenses associated with any transfer or exchange,  including
without limitation,  any tax or other governmental charge that may be imposed in
relation thereto.

     Section 9.   Replacement Securities.
     ------------------------------------

          If the Note is mutilated and is surrendered  to the  Corporation or if
Holder presents evidence to the reasonable  satisfaction of the Corporation that
the Note has been lost,  destroyed or wrongfully  taken,  the Corporation  shall
issue a replacement Note of like tenor. The Corporation shall bear all costs and
expenses associated with replacing the Note.

     Section 10.   No Recourse Against Others.
     -----------------------------------------

          No  director,  officer,  employee  or  stockholder,  as  such,  of the
Corporation  shall have any liability  for any  obligations  of the  Corporation
under the Note or for any  claim  based on, in  respect  or by reason  of,  such
obligations or their creation;  provided,  however, that nothing in this Section
10 shall in any way diminish or detract from Holder's interest in the Collateral
securing the payment of and performance by the Corporation of this Note.  Holder
by accepting this Note waives and releases all such  liability.  This waiver and
release are part of the consideration for the issue of the Note.

     Section 11.   Notice.
     ---------------------

          All notices,  requests,  consents and demands shall be made in writing
and shall be delivered  personally or mailed by  registered  or certified  mail,
return receipt  requested and 


                                       10
<PAGE>


postage  prepaid,  to the  Corporation  at 301 South State Street,  Newtown,  PA
18940,  or to such other address as may be furnished in writing to the Holder of
the Note or to the Holder at its  address  listed on the  transfer  books of the
Corporation.  Unless  otherwise  indicated  herein,  notices  hereunder shall be
effective when  delivered,  if delivered  personally,  or, if sent by mail, when
sent.

          The Corporation  hereby waives protest,  demand,  notice of nonpayment
and all other notices in connection with the delivery,  acceptance,  performance
or  enforcement  of this Note.  Any failure or delay of Holder to  exercise  any
right  hereunder shall not be construed as a waiver of the right to exercise the
same or any other  right at any other  time or times.  The waiver by Holder of a
breach or  default  of any  provision  of this  Note  shall  not  operate  or be
construed  as a  waiver  of  any  subsequent  breach  or  default  thereof.  The
Corporation  agrees to  reimburse  Holder for all  expenses,  including  without
limitation,  attorneys' fees and disbursements of counsel, incurred by Holder to
enforce the provisions of this Note,  protect and preserve Holder's rights under
the Agreement, and collect the Corporation's obligations hereunder.

     Section 12.   Governing Law.
     ----------------------------

          This Note shall be deemed a contract under,  and shall be governed and
construed in accordance  with,  the laws of the  Commonwealth  of  Pennsylvania,
without giving effect to principles of conflicts of laws. The provisions of this
Note are severable and the invalidity or unenforceability of any provision shall
not alter or impair the remaining provisions of this Note.


                                       11
<PAGE>


          IN WITNESS WHEREOF,  the Corporation has caused this Note to be signed
manually or by facsimile by its duly authorized  officers and its corporate seal
or a facsimile thereof to be affixed hereto or imprinted hereon.

Dated:  March 19, 1999.

                                       COLLAGENEX PHARMACEUTICALS, INC.


                                       By:/s/ BM Gallagher
                                          -----------------------------------
                                       Name:  BM Gallagher
                                       Title: President and CEO



Attest:

/s/ Nancy C. Broadbent
- ----------------------
Secretary



                                       12





- --------------------------------------------------------------------------------

                            STOCK PURCHASE AGREEMENT

                                  by and among

                        COLLAGENEX PHARMACEUTICALS, INC.

                     OCM PRINCIPAL OPPORTUNITIES FUND, L.P.

                                       and

                           THE PURCHASERS NAMED HEREIN


                           Dated as of March 19, 1999


- --------------------------------------------------------------------------------



<PAGE>


                                TABLE OF CONTENTS

                                                                          Page
                                                                          ----

ARTICLE I  SALE AND PURCHASE OF SECURITIES...................................1
      1.1  Sale and Purchase of Preferred Stock..............................1
      1.2  Closing...........................................................2
ARTICLE II  REPRESENTATIONS AND WARRANTIES OF THE COMPANY....................3
      2.1   Certificate of Incorporation Stock...............................3
      2.2   Issuance of Series D Preferred Stock and Reservation of 
             Reserved Shares.................................................3
      2.3   Organization and Qualification...................................3
      2.4   Capitalization...................................................4
      2.5   Authority Relative to this Agreement.............................5
      2.6   Absence of Certain Changes.......................................5
      2.7   Reports..........................................................6
      2.8   Financial Reports................................................7
      2.9   No Violation; Consents and Approvals.............................7
      2.10  Brokerage Fees and Commissions...................................8
      2.11  Litigation.......................................................8
      2.12  Absence of Changes in Benefit Plans..............................8
      2.13  ERISA Compliance.................................................8
      2.14  Taxes...........................................................11
      2.15  Permits; Environmental Matters..................................11
      2.16  Contracts; Debt Instruments.....................................12
      2.17  Title to Properties.............................................13
      2.18  Intellectual Property...........................................14
      2.19  Certain Agreements..............................................14
      2.20  Indemnification Claims..........................................14
      2.21  Antitakeover Statute; Shareholder Protection Rights Agreement...14
      2.22  Protective Agreements...........................................15
      2.23  Other Agreements Containing Non-Disclosure and Non-Competition
             Provisions.....................................................15
      2.24  Patents.........................................................16
      2.25  Related Transactions............................................16
      2.26  Amendments to Certificate of Incorporation......................16
      2.27  Public Announcements............................................16
      2.28  Use of Proceeds.................................................17
      2.29  S-8 Amendment...................................................17
      2.30  Disclosure......................................................17
ARTICLE III  REPRESENTATIONS AND WARRANTIES OF INVESTOR AND PURCHASERS......17
      3.2  Authority Relative to this Agreement; No Conflict................18
      3.4  Investment Intent................................................18
      3.4  Purchasers' Counsel..............................................18
      3.5  Economic Risk....................................................18
      3.6  Additional Representations.......................................19


                                      -i-


<PAGE>


ARTICLE III-A COVENANTS.....................................................19
      3A.1  Conduct of Business of the Company..............................19
      3A.2  Existence; Maintenance of Property..............................21
      3A.3  No Solicitation.................................................21
      3A.4  Access to Information...........................................21
      3A.5  Proxy Statement and Stockholder Meeting.........................22
      3A.6  NASDAQ Listing..................................................22
      3A.7  Reasonable Best Efforts.........................................22
      3A.8  Shareholder Litigation..........................................23
      3A.9  Financial Reports...............................................23
ARTICLE IV  CONDITIONS TO CLOSING...........................................25
      4.1  Conditions to Investor's Obligations for Closing.................25
      4.2  Conditions to the Company's Obligations for the Closing..........27
ARTICLE V  INDEMNIFICATION..................................................27
      5.1  Indemnification by the Company...................................27
      5.2  Indemnification by Investor and Purchasers.......................27
      5.3  Procedure for Indemnification....................................28
      5.4  Procedure for Indemnification....................................29
ARTICLE VI  MISCELLANEOUS...................................................29
      6.1  Termination; Effect of Termination; Expenses.....................29
      6.2  Extension; Waiver................................................30
      6.3  Entire Agreement; Assignment.....................................30
      6.4  Enforcement of the Agreement; Governing Law; Jurisdiction........30
      6.5  Validity.........................................................31
      6.6  Notices..........................................................31
      6.7  Descriptive Headings.............................................33
      6.8  Parties in Interest..............................................33
      6.9  Counterparts.....................................................33
      6.10  Amendment.......................................................33
      6.11  Survival........................................................33
      6.12  Certain Definitions.............................................34


                                       -ii-


<PAGE>


                                    EXHIBITS

Exhibit A     Certificate of Designation, Preferences and Rights of Series D
              Cumulative Convertible Preferred Stock
Exhibit B-1   Opinion of Counsel to the Company
Exhibit B-2   Opinion of Patent Counsel to the Company
Exhibit C     List of Purchasers
Exhibit D     Stockholders and Registration Rights Agreement
Exhibit E     Notice Information for Purchasers

                                    SCHEDULES

Schedule 2.3(a)    List of Jurisdictions for Foreign Qualification
Schedule 2.4(c)    List of Holders of Option Shares; List of Holders
Schedule 2.4(d)    Warrants, Options, etc.
Schedule 2.6       Certain Changes
Schedule 2.12      Absence of Changes in Benefit Plans
Schedule 2.13      List of Benefit Plans
Schedule 2.15      Permits; Environmental Matters
Schedule 2.16(a)   Material Contracts
Schedule 2.16(b)   Indebtedness
Schedule 2.16(c)   Agreements Involving the Payment of $50,000 or More per Year
Schedule 2.18      Intellectual Property
Schedule 2.19      Contracts that Limit the Company's Ability to Compete
Schedule 2.22      Protective Agreements with Directors, Officers and Employees
Schedule 2.23      Other Agreements Containing Non-Disclosure and 
                   Non-Competition Provisions
Schedule 3A.1      Conduct of Business of the Company


                                     -iii-


<PAGE>


                                  DEFINED TERMS

affiliate...................................................................34
Agreement....................................................................1
associate...................................................................34
beneficial owner............................................................34
Budget......................................................................24
Closing......................................................................2
Closing Date.................................................................2
COBRA........................................................................9
Code.........................................................................8
Common Stock.................................................................1
Company......................................................................1
confidential information....................................................15
control.....................................................................34
DGCL.........................................................................8
Employee Benefit Plans.......................................................8
Environmental Laws..........................................................11
Environmental Permits.......................................................12
ERISA........................................................................8
Exchange Act.................................................................6
Foundation..................................................................16
fully diluted...............................................................34
Governmental Entity..........................................................7
Hazardous Substance.........................................................12
indemnified party...........................................................28
Intellectual Property.......................................................13
Investor.....................................................................1
Investor Purchase Price......................................................1
Liens........................................................................3
Loss........................................................................27
Material Adverse Effect.....................................................34
NASDAQ.......................................................................1
NCA.........................................................................14
NDA.........................................................................14
NYSE........................................................................22
Opinion of the Company's Counsel............................................26
Opinion of the Company's Patent Counsel.....................................26
Patent Agreements...........................................................16
person......................................................................35
Protective Agreements.......................................................14
Proxy Statement.............................................................22
Purchaser Purchase Price,....................................................2
Related Transactions........................................................16
S-8 Amendment...............................................................17


                                      -iv-


<PAGE>


SEC Documents................................................................6
Securities Act...............................................................6
Series D Certificate of Designation.........................................16
Series D Preferred Stock.....................................................1
Shareholder Protection Rights Agreement.....................................14
subsidiary..................................................................35
Taxes.......................................................................11
Third Party Claim...........................................................28
Total Purchase Price.........................................................2




                                       -v-


<PAGE>


                            STOCK PURCHASE AGREEMENT



          THIS IS A STOCK  PURCHASE  AGREEMENT,  dated as of March 19, 1999 (the
"Agreement."),  by and  between  COLLAGENEX  PHARMACEUTICALS,  INC.,  a Delaware
corporation,  having its principal  office at 301 South State  Street,  Newtown,
Pennsylvania 19940 (the "Company"),  OCM PRINCIPAL  OPPORTUNITIES  FUND, L.P., a
Delaware limited partnership, having its principal office at c/o Oaktree Capital
Management,  LLC, 333 South Grand A5venue,  28th Floor, Los Angeles,  California
90071 (the  "Investor")  and the  persons  named on Exhibit C to this  Agreement
(individually a "Purchaser" and collectively the "Purchasers").

                                   BACKGROUND
                                   ----------

          WHEREAS,  the Company  currently has issued and outstanding  8,587,204
shares of Common Stock, par value one-cent  ($0.01) per share ("Common  Stock").
The Company's  Common Stock is currently  traded on the Nasdaq  National  Market
("NASDAQ").

          WHEREAS,  the  Company is engaged in the  business of  developing  and
commercializing   innovative   proprietary   therapies   for  the  treatment  of
periodontal disease and other pathologies;

          WHEREAS,  the  Company  intends  to  issue  the  Series  D  Cumulative
Convertible  Preferred  Stock,  one-cent  ($0.01) par value ("Series D Preferred
Stock"); and

          WHEREAS,  Investor  and  Purchasers  desire to  purchase  the Series D
Convertible  Preferred  Stock,  subject  to the terms and  conditions  contained
herein.

                                      TERMS
                                      -----

          NOW,  THEREFORE,  in consideration  of the mutual covenants  contained
herein,  and intending to be legally bound hereby,  the parties  hereto agree as
follows:

                                    ARTICLE I

                         SALE AND PURCHASE OF SECURITIES
                         -------------------------------

1.1   SALE AND PURCHASE OF PREFERRED STOCK.

               (a) Subject to the terms and conditions set forth herein,  at the
Closing  (as  defined in Section  1.2(a)),  the  Company  will issue and sell to
Investor, and Investor will purchase from the Company, One Hundred Seventy-Seven
Thousand  (177,000)  shares  of the  Series D  Preferred  Stock.  The  aggregate
purchase  price for the Series D Preferred  Stock being  purchased  hereunder is
Seventeen  Million Seven Hundred Thousand Dollars  ($17,700,000)  (the "Investor
Purchase Price").


<PAGE>


               (b) Subject to the terms and conditions set forth herein,  at the
Closing,  the Company will issue and sell to each Purchaser,  and each Purchaser
will purchase from the Company, the number of shares of Series D Preferred Stock
set forth beside the name of each  Purchaser on Exhibit C hereto.  The aggregate
purchase price for the Series D Preferred Stock being purchased by each Purchase
is set forth on Exhibit C hereto (the "Purchaser  Purchase  Price," and together
with the Investor Purchase Price, the "Total Purchase Price").

               (c) The total number of shares of Series D Preferred  Stock to be
purchased  from the Company by Investor  is One Hundred  Seventy-Seven  Thousand
(177,000)  and the total  number of  shares  of Series D  Preferred  Stock to be
purchased  from the Company by each  Purchaser is set forth on Exhibit C hereto.
The per share  purchase  price for the  Series D  Preferred  Stock to be paid by
Investor and each Purchaser  pursuant to this Section 1.1 is One Hundred Dollars
($100) per share. At Closing, Investor shall pay the Investor Purchase Price for
the shares of Series D Preferred Stock purchased by Investor hereunder, and each
Purchaser  shall pay the  Purchaser  Purchase  Price for the  shares of Series D
Preferred  Stock  purchased by such  Purchaser,  by wire transfer of immediately
available  funds to an account  designated  by the Company not less than two (2)
business days prior to Closing.

          1.2   CLOSING.

               (a) The closing of the  purchase and sale of the shares of Series
D Preferred  Stock  referred to in Section 1.1 above (the  "Closing")  will take
place  as soon as  practicable  after  the  Company's  1999  Annual  Meeting  of
Stockholders  and  prior to June 30,  1999 at the  offices  of  Dechert  Price &
Rhoads, 4000 Bell Atlantic Tower, 1717 Arch Street,  Philadelphia,  Pennsylvania
19103-2793,  on such date to be  mutually  agreed  by the  parties  hereto  (the
"Closing Date").

               (b) At  Closing,  the  Company  will  deliver to Investor a stock
certificate  representing One Hundred Seventy-Seven Thousand (177,000) shares of
Series D Preferred Stock,  registered in the name of Investor or an affiliate or
associate  of Investor.  Delivery is being made against  payment of the Investor
Purchase  Price  therefor in cash,  by wire  transfer of  immediately  available
funds, with confirmed receipt.

               (c) At Closing,  the  Company  will  deliver to each  Purchaser a
stock certificate  representing the number of shares of Series D Preferred Stock
set forth beside the name of each  Purchaser on Exhibit C hereto,  registered in
the name of each  Purchaser.  Delivery  is being  made  against  payment  of the
Purchaser  Purchase  Price  therefor in cash,  by wire  transfer of  immediately
available funds, with confirmed receipt.



                                      -2-
<PAGE>


                                   ARTICLE II

                         REPRESENTATIONS AND WARRANTIES
                                 OF THE COMPANY
                                 --------------


          The Company  hereby  represents  and  warrants  to  Investor  and each
Purchaser as follows:

          2.1  CERTIFICATE  OF  INCORPORATION.  The  Company  has filed with the
Secretary of State of the State of Delaware an amendment to its  Certificate  of
Incorporation incorporating the Certificate of Designation.

          2.2 ISSUANCE OF SERIES D PREFERRED  STOCK AND  RESERVATION OF RESERVED
SHARES.  Subject to the terms and conditions  hereof, the Company has authorized
the issuance of the shares of Series D Preferred Stock; and the Company has also
authorized  the  reservation of the shares of Common Stock reserved for issuance
upon  conversion of the Series D Preferred  Stock and dividends,  when declared,
with respect to the Series D Preferred Stock.

          2.3 ORGANIZATION AND QUALIFICATION.

               (a) The Company is a corporation duly organized, validly existing
and in good  standing  under  the  laws of the  State  of  Delaware  and has the
requisite corporate power to carry on its business as it is now being conducted.
The Company is duly qualified as a foreign corporation to do business, and is in
good standing,  in each jurisdiction where the character of its properties owned
or leased or the nature of its activities  makes such  qualification  necessary,
except where the failure to be so qualified  could not reasonably be expected to
result in a Material  Adverse Effect (as defined in Section  6.12(e)).  Schedule
2.3(a) attached hereto sets forth a list of  jurisdictions  in which the Company
is so qualified to do business and is in good standing as a foreign corporation.

               (b)  The  only   subsidiary   of  the   Company   is   CollaGenex
International, Ltd., which is a corporation duly organized, validly existing and
in good standing under the laws of its jurisdiction of incorporation and has the
requisite corporate power to carry on its business as it is now being conducted.
The subsidiary of the Company is duly  qualified as a foreign  corporation to do
business,  and is in good standing,  in each jurisdiction where the character of
its  properties  owned or  leased  or the  nature  of its  activities  make such
qualification  necessary,  except where the failure to be so qualified could not
be  reasonably  expected  to result in a  Material  Adverse  Effect.  All of the
outstanding  shares of capital stock of the subsidiary have been validly issued,
are fully paid and non-assessable and are owned by the Company free and clear of
all pledges, claims, equities, options, liens, charges, rights of first refusal,
"tag" or "drag" along rights, encumbrances and security interests of any kind or
nature whatsoever  (collectively,  "Liens"). Except for the capital stock of its
subsidiary,  the  Company  has  never  had,  nor  does it  presently  have,  any
subsidiaries,  nor has it owned, nor does it presently own, any capital stock or
other proprietary interest or other voting control,  directly or indirectly,  in
any corporation,


                                      -3-
<PAGE>


association,  trust,  partnership,  limited liability company,  joint venture or
other entity. The Company is, however, currently evaluating whether to establish
two (2) separate Delaware Investment Holding Companies through which the Company
would  separately  hold and manage its  intellectual  property  and its cash and
liquid investment balances.

               (c) The Company has  delivered  to Investor  complete and correct
copy of its Certificate of Incorporation, certified by the Secretary of State of
the State of  Delaware,  and a complete  and correct  copy of its Bylaws and the
comparable  charters  and  bylaws  or  other  organizational  documents  of  its
subsidiary, in each case as amended to the date of this Agreement.

          2.4  CAPITALIZATION.  The  authorized  capital  stock  of the  Company
immediately upon the  consummation at Closing of the  transactions  contemplated
hereby, and giving effect thereto, shall consist of:

               (a) Four Million Eight  Hundred  Thousand  (4,800,000)  shares of
undesignated preferred stock, $0.01 par value;

               (b) Two Hundred  Thousand  (200,000) shares of Series D Preferred
Stock, of which One Hundred  Seventy-Seven  Thousand  (177,000) shares have been
validly issued to Investor and of which  Twenty-Three  Thousand  (23,000) shares
have been validly  issued to Purchasers in the amounts set forth on Exhibit C at
Closing and are outstanding,  fully paid and non-assessable  upon receipt of the
Total Purchase Price pursuant to Section 1.1 hereof, with only limited liability
attaching solely to the ownership thereof under applicable state law;

               (c) Twenty Five Million  (25,000,000)  shares of Common Stock, of
which (i) Eight  Million  Five  Hundred  Eighty-Seven  Thousand Two Hundred Four
(8,587,204)  shares  are  validly  issued  and  outstanding,  and fully paid and
non-assessable,  and (ii) Two  Million Two Hundred  Seventy-Six  Thousand  Three
Hundred  Sixty-Four  (2,276,364)  shares  are  duly  reserved  for  issuance  in
connection  with the  conversion of the Series D Preferred  Stock and payment of
dividends  on the Series D Preferred  Stock as set forth in the  Certificate  of
Designation.  Nine  Million  Seven  Hundred  Eighty  Four  Thousand  Six Hundred
Sixty-Three  (9,784,663)  shares of Common Stock  represent the Company's  total
common equity on a fully-diluted  basis  (including  without  limitation  shares
outstanding and shares  issuable upon the exercise of the rights  outstanding as
of the date of  execution  of this  Agreement  referred to in  Schedule  2.4(d))
(Schedule  2.4(d)  attached  hereto  lists all of the shares of Common  Stock by
holder  issuable upon exercise of such rights).  Schedule 2.4(c) attached hereto
contains a list of (y) all holders of record owning five percent (5%) or more of
outstanding  capital stock of the Company and (z) all other holders known to the
Company,  of five  percent  (5%) or more of  outstanding  capital  stock  of the
Company  and holders  known to the  Company to have filed a Schedule  13D or 13G
under the Exchange  Act,  including,  for both (y) and (z) above,  the number of
shares of outstanding capital stock of the Company held by each such holder; and


                                      -4-
<PAGE>


               (d)  Schedule  2.4(d)  attached  hereto  contains  a list  of all
outstanding  warrants,  options,  agreements,  convertible  securities  or other
commitments  pursuant to which the Company or its  subsidiary  are or may become
obligated to issue any shares of their capital stock or other  securities of the
Company or its  subsidiary,  which  names all persons  entitled to receive  such
shares  or  securities  and the  shares  of  capital  stock or other  securities
required to be issued thereunder. There are no bonds, debentures, notes or other
indebtedness  of the  Company  or its  subsidiary  having  the right to vote (or
convertible into, or exchangeable  for,  securities having the right to vote) on
any matters on which  stockholders  of the Company or its  subsidiary  may vote.
Except as set forth on Schedule  2.4(d),  there are no  outstanding  securities,
options,  warrants,  calls,  rights,  commitments,  agreements,  arrangements or
undertakings of any kind to which the Company or its subsidiary is a party or by
which the  Company or its  subsidiary  is bound  obligating  the  Company or its
subsidiary to issue, deliver or sell, or cause to be issued,  delivered or sold,
directly  or  indirectly,  additional  shares of capital  stock or other  voting
securities of the Company or its  subsidiary,  or obligating  the Company or its
subsidiary  to issue,  grant,  extend or enter into any such  security,  option,
warrant, call, right, commitment,  agreement, arrangement or undertaking. Except
as set  forth on  Schedule  2.4(d),  there are not any  outstanding  contractual
obligations of the Company or its subsidiary to repurchase,  redeem or otherwise
acquire,  or providing  preemptive or  registration  rights with respect to, any
shares of capital  stock of the Company or its  subsidiary.  The Company and its
subsidiary  do not have  outstanding  any loans to any  person  (as  defined  in
Section 6.12(f)) in respect of the purchase of securities  issued by the Company
and its subsidiary.

          2.5  AUTHORITY  RELATIVE  TO  THIS  AGREEMENT.  The  Company  has  all
requisite  corporate  power and authority to execute and deliver this  Agreement
and to  consummate  the  transactions  contemplated  hereby.  The  execution and
delivery of this Agreement by the Company and the consummation by the Company of
the transactions  contemplated  hereby have been duly and validly  authorized by
the Board of Directors of the Company, and no other corporate proceedings on the
part of the Company are necessary to authorize  this  Agreement or to consummate
the  transactions  so  contemplated.  This  Agreement  has been duly and validly
executed and delivered by the Company,  and, assuming this Agreement constitutes
a valid  and  binding  obligation  of each  Investor  and each  Purchaser,  this
Agreement constitutes a valid and binding agreement of the Company,  enforceable
against the Company in accordance with its terms.

          2.6  ABSENCE  OF  CERTAIN  CHANGES.  Except  as  disclosed  in the SEC
Documents (as defined in Section 2.7 below) or as contemplated by this Agreement
or as set forth in Schedule 2.6 attached  hereto,  since  December 31, 1997,  no
event has  occurred,  and no  circumstances  exist,  that  could  reasonably  be
expected to result in a Material  Adverse Effect (as defined in Section  6.12(e)
below).  Except as  disclosed  in the  Company's  filings and reports  under the
Exchange Act (as defined in Section 2.7 below) or as set forth in Schedule  2.6,
since December 31, 1997, there has not been (a) any  declaration,  setting aside
or payment of any dividend or other distribution in respect of the capital stock
of the Company or its subsidiary or any  redemption or other  acquisition by the
Company  or its  subsidiary  of any  shares  of  Common


                                      -5-
<PAGE>


Stock or other equity securities of the Company or its subsidiary; (b) any entry
into any  agreement,  commitment or transaction by the Company or its subsidiary
which is material to the Company  and its  subsidiary  taken as a whole,  except
agreements,  commitments  or  transactions  in the ordinary  course of business,
consistent with prior practice;  (c) any split,  combination or reclassification
of the  Company's  capital  stock or any  issuance or the  authorization  of any
issuance of any other  securities  in respect of, in lieu of or in  substitution
for shares of its  capital  stock;  (d)(i) any  granting  by the  Company or its
subsidiary  to any officer of the Company or its  subsidiary  of any increase in
compensation,  except in the ordinary  course of business  consistent with prior
practice or as was required under employment agreements in effect as of the date
of the most recent audited financial  statements  included in the SEC Documents,
(ii) any  granting by the Company or its  subsidiary  to any such officer of any
increase  in  severance  or  termination  pay,  except  as  was  required  under
employment,  severance or termination agreements in effect as of the date of the
most recent audited financial statements included in the SEC Documents, or (iii)
any entry by the Company or its  subsidiary  into any  employment,  severance or
termination  agreement  with any such officer;  (e) any damage,  destruction  or
loss, whether or not covered by insurance,  that could reasonably be expected to
have a  Material  Adverse  Effect;  or (f) any  change  in  accounting  methods,
principles  or  practices  by  the  Company  materially  affecting  its  assets,
liabilities or business, except insofar as may have been required by a change in
generally accepted accounting  principles,  consistently  applied.

          2.7 REPORTS.  Since June 25, 1996,  the Company has filed all required
forms, reports and documents with the SEC required to be filed by it pursuant to
the federal securities laws and the rules and regulations promulgated thereunder
(collectively,  the "SEC  Documents"),  all of which have  complied  as of their
respective   filing  dates  in  all  material   respects  with  all   applicable
requirements  of the Securities Act of 1933, as amended (the  "Securities  Act")
and the Securities  Exchange Act of 1934, as amended (the "Exchange  Act"),  and
the rules and regulations promulgated thereunder. None of such forms, reports or
documents at the time filed contained any untrue statement of a material fact or
omitted to state a material fact  required to be stated  therein or necessary in
order to make the statements  therein, in light of the circumstances under which
they were made, not misleading.  Except to the extent that information contained
in any SEC Document has been revised or superseded by a later-filed SEC Document
filed and publicly available prior to the date hereof, none of the SEC Documents
contains any untrue  statement of a material fact or omits to state any material
fact required to be stated  therein or necessary in order to make the statements
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  The  financial  statements  of the  Company  included  in  the  SEC
Documents comply as to form in all material respects with applicable  accounting
requirements  and the published  rules and  regulations  of the SEC with respect
thereto,  have been prepared in accordance  with generally  accepted  accounting
principles  (except, in the case of unaudited  statements,  as permitted by Form
10-Q of the SEC)  applied on a  consistent  basis  during the  periods  involved
(except  as may be  indicated  in the notes  thereto)  and  fairly  present  the
consolidated  financial  position of the Company  and its  subsidiary  as of the
dates thereof and the consolidated  results of its operations and cash flows for
the periods then ended (subject, in the case of unaudited statements,  to normal
year-end audit adjustments).


                                      -6-
<PAGE>


          2.8 FINANCIAL REPORTS. The audited,  consolidated financial statements
for the Company and its  subsidiary  for the period ended December 31, 1997; the
unaudited quarterly financial  statements for the Company and its subsidiary for
each of the quarterly  periods ended March 31, 1998, June 30, 1998 and September
30, 1998; and the unaudited  monthly  financial  statements for the months ended
October, 1998, November,  1998, December,  1998 and January, 1999, and the draft
audited annual consolidated  financial statements for 1998,  previously provided
to Investor are true, correct and complete in all material respects,  and comply
as to form in all material respects with applicable accounting  requirements and
the rules and regulations of the SEC with respect thereto, have been prepared in
accordance with generally accepted  accounting  principles (except to the extent
permitted  by Form 10-Q of the SEC)  applied on a  consistent  basis  during the
periods  involved  (except as may be indicated in the notes  thereto) and fairly
present the consolidated financial position of the Company and its subsidiary as
of the date thereof and the  consolidated  results of their  operations and cash
flows for the periods then ended.  Since the date of such financial  statements,
there  have  been  no  changes  that  could  reasonably  be  expected  to  have,
individually  or in  the  aggregate,  a  Material  Adverse  Effect.  Except  for
liabilities incurred in the ordinary course of business,  which individually and
in the aggregate are not  material,  the Company and its  subsidiary do not have
any  liabilities or obligations of any nature (whether  absolute,  contingent or
otherwise) that, individually or in the aggregate,  could reasonably be expected
to have a Material Adverse Effect other than such  liabilities  reflected on the
financial  statements  referred  to  hereinabove  in this  Section  2.8.

          2.9 NO VIOLATION;  Consents and  Approvals.  Neither the execution and
delivery  of  this  Agreement  by  the  Company  nor  the  consummation  of  the
transactions  contemplated hereby will conflict with, or result in any violation
of or default under (with or without notice or lapse of time, or both),  or give
rise to a right of  termination,  cancellation or acceleration of any Liens upon
any of the properties or assets or the Company or its subsidiary  under, (a) the
Certificate of Incorporation or Bylaws of the Company or its subsidiary, each as
amended,  (b) any loan or credit  agreement,  note, bond,  mortgage,  indenture,
lease or other agreement,  instrument, permit, concession,  franchise or license
applicable to the Company or its subsidiary or their properties or assets or (c)
subject  to the  governmental  filings  and  other  matters  referred  to in the
following sentence, any judgment,  order, decree, statute, law, ordinance,  rule
or regulation applicable to the Company or its subsidiary or their properties or
assets,  other  than,  in the case of clauses  (b) or (c),  any such  conflicts,
violations,  defaults,  rights or Liens that,  individually or in the aggregate,
could not reasonably be expected to have a Material Adverse Effect.  No consent,
approval,  order or  authorization  of, or  registration,  declaration or filing
with, (x) any Federal, state or local government or any court, administrative or
regulatory  agency or  commission  or other  governmental  authority  or agency,
domestic or foreign (a  "Governmental  Entity" ), (y)  NASDAQ,  or (z) any third
party,  is required  by the Company or its  subsidiary  in  connection  with the
execution and delivery of this Agreement by the Company or the  consummation  by
the Company of the transactions  contemplated by this Agreement,  except for (i)
the  filing  with the SEC of a notice on Form D or such  reports  under  Section
13(a) of the Exchange Act as may be required in connection  with this  Agreement
and the  transactions  contemplated  by this  Agreement,  (ii) the filing of the
Series D Certificate  of  Designation  (as such


                                      -7-
<PAGE>


term is  defined in Section  2.26) with the  Secretary  of State of the State of
Delaware  pursuant to the Delaware General  Corporation Law (the "DGCL"),  (iii)
applicable  state "blue sky" filings,  if any, (iv) approval of the transactions
contemplated  hereby by the  stockholders  of the  Company,  and (v) such  other
consents,  approvals, orders,  authorizations,  registrations,  declarations and
filings, which have been obtained or made or the failure of which to be obtained
or made,  individually or in the aggregate,  could not reasonably be expected to
have a Material Adverse Effect.  

          2.10 BROKERAGE FEES AND COMMISSIONS.  No person or entity,  other than
BT Alex.  Brown  Incorporated,  is entitled  to receive  from the Company or its
subsidiary any investment banking,  brokerage or finder's fee in connection with
this     Agreement     or     the     transactions      contemplated     hereby.

          2.11 LITIGATION. There is no suit, action or proceeding pending or, to
the knowledge of the Company,  threatened  against the Company or its subsidiary
that could  reasonably  be expected to have a Material  Adverse  Effect,  nor is
there any judgment, decree, injunction, rule or order of any Governmental Entity
or  arbitrator  outstanding  against  the Company or its  subsidiary  that could
reasonably be expected to have a Material Adverse Effect.

          2.12 ABSENCE  OF CHANGES  IN  BENEFIT  PLANS.  Except as set forth  in
Schedule  2.12,  there has not been any  adoption or  amendment  in any material
respect by the Company or its subsidiary of any collective  bargaining agreement
or any Employee  Benefit Plan, as defined in Section  2.13(a) of this Agreement.

          2.13 ERISA  COMPLIANCE.  

               (a) LIST OF PLANS.  Set forth in Schedule 2.13 attached hereto is
an accurate  and  complete  list of all employee  benefit  plans,  as defined in
Section 3(3) of the Employee  Retirement Income Security Act of 1974, as amended
("ERISA")  (including  any  "multiemployer  plan" as defined in Section 3(37) of
ERISA), and all other pension,  retirement,  supplemental  retirement,  deferred
compensation,  excess benefit, profit sharing, bonus, incentive, stock purchase,
stock ownership, stock option, stock appreciation right, employment,  severance,
salary continuation, termination,  change-of-control,  health, life, disability,
group insurance,  vacation,  holiday and fringe benefit plan, program, contract,
or arrangement (whether written or unwritten, qualified or nonqualified,  funded
or unfunded and including any that have been frozen or  terminated)  maintained,
contributed  to, or required to be  contributed  to, by the Company or any ERISA
Affiliate for the benefit of any employee, former employee,  director or officer
of the  Company  or under  which  the  Company  or any ERISA  Affiliate  has any
liability with respect to any employee, former employee,  director or officer of
the Company ("Employee Benefit Plans"). The term "ERISA Affiliate" means (i) any
corporation  included  with the Company in a  controlled  group of  corporations
within the meaning of Section  414(b) of the Internal  Revenue Code of 1986,  as
amended (the "Code");  (ii) any trade or business  (whether or not incorporated)
which is under  common  control  with the Company  within the meaning of Section
414(c) of the 


                                      -8-
<PAGE>


Code; (iii) any member of an affiliated  service group of which the Company is a
member  within  the  meaning of  Section  414(m) of the Code;  or (iv) any other
person or entity  treated as an affiliate of the Company under Section 414(o) of
the Code.

               (b) STATUS OF PLANS.  Each Employee  Benefit Plan  (including any
related trust)  complies in form with, and has at all times been  maintained and
operated in compliance  with its terms and, the  requirements  of all applicable
laws,  including,  without  limitation,  ERISA,  the Code  and the  Consolidated
Omnibus Budget Reconciliation Act ("COBRA"). No condition or circumstance exists
that would prevent the amendment or termination of any Employee Benefit Plan.

               (c)  LIABILITIES.  No Employee Benefit Plan is now or at any time
has been subject to Part 3, Subtitle B of Title I of ERISA or Title IV of ERISA.
Neither the Company or any current ERISA Affiliate is, or within the seven years
immediately  preceding the date of this Agreement was, required to contribute to
any  multiemployer  plan,  as  defined by section  3(37) of ERISA.  Neither  the
Company nor any ERISA  Affiliate,  while an ERISA  Affiliate,  has  incurred any
withdrawal  liability,  within  the  meaning  of  Section  4201 of  ERISA to any
multiemployer  plan,  which  liability  has not been  fully  paid as of the date
hereof. No Employee Benefit Plan which is a "group health plan" (as such term is
defined  in  Section  5000(b)(1)  of the Code or  Section  607(1) of ERISA) is a
"multiple employer welfare  arrangement," within the meaning of Section 3(40) of
ERISA.  Neither the Company nor any of its  subsidiaries  maintains any Employee
Benefit Plan (whether  qualified or  non-qualified  under Section  401(a) of the
Code) providing for  post-employment  or retiree health,  life insurance  and/or
other welfare benefits and having unfunded liabilities.  Neither the Company nor
any of its  subsidiaries has any unfunded  liabilities  pursuant to any employee
benefit  pension plan (as defined in Section 3(2) of ERISA) that is not intended
to be qualified under Section 401(a) of the Code. No asset of the Company or any
of its subsidiaries is subject to any lien arising under Section 302(f) of ERISA
or Section  412(n) of the Code,  and, to the knowledge of the Company,  no event
has occurred and no condition or circumstance  exists that is reasonably  likely
to give rise to any such lien.  Neither the Company nor any of its  subsidiaries
has been required to provide any security  under Section 307 of ERISA or Section
401(a)(29) or 412(f) of the Code, and, to the knowledge of the Company, no event
has occurred and no condition or circumstance  exists that is reasonably  likely
to give rise to any such requirement to provide any such security.

               (d) ABSENCE OF LITIGATION.  There are no actions,  suits, claims,
or  disputes  pending,  or,  to the  knowledge  of the  Company,  threatened  or
reasonably  expected  to be  asserted  against or with  respect to any  Employee
Benefit  Plan or the  assets of any such plan  (other  than  routine  claims for
benefits and appeals of denied routine  claims) or with respect to any fiduciary
with respect thereto.

               (e)  CONTRIBUTIONS.  Full  payment  has been  timely  made of all
amounts which the Company or any ERISA Affiliate is required,  under  applicable
law or under any Employee Benefit Plan or any agreement relating to any Employee
Benefit  Plan to which the 


                                      -9-
<PAGE>


Company or any ERISA  Affiliate  is a party,  to have paid as  contributions  or
premiums  thereto  as of the  last day of the most  recent  fiscal  year of such
Employee Benefit Plan ended prior to the Closing.

               (f) TAX QUALIFICATION.  Each Employee Benefit Plan intended to be
qualified  under  Section  401(a) of the Code has, as currently in effect,  been
determined to be so qualified by the IRS or an application  for a  determination
letter  will be  submitted  to the IRS no later  than the end of the  applicable
remedial  amendment period as described in Section 401(b) of the Code. Since the
date of each most recent  determination  referred to in this  paragraph  (f), no
event has occurred and no condition or circumstance has existed that resulted or
is reasonably  likely to result in the revocation of any such  determination  or
that would adversely  affect the qualified  status of any such Employee  Benefit
Plan or the exempt status of any such trust.

               (g) TRANSACTIONS. Neither the Company nor any ERISA Affiliate nor
any of their respective directors,  officers,  employees or, to the knowledge of
the Company,  other  Persons who  participate  in the  operation of any Employee
Benefit Plan or related trust or funding vehicle, has engaged in any transaction
with respect to any Employee  Benefit Plan or breached any applicable  fiduciary
responsibilities or obligations under Title I of ERISA that would subject any of
them to a tax, penalty or liability for prohibited transactions or breach of any
obligations  under  ERISA or the Code or would  result in any claim  being  made
under,  by or on  behalf of any such  Employee  Benefit  Plan by any party  with
standing  to make such claim.

               (h)  TRIGGERING  EVENTS.  The execution of this Agreement and the
consummation  of the  transactions  contemplated  hereby,  do not  constitute  a
triggering event under any Employee Benefit Plan or arrangement,  whether or not
legally  enforceable,  which  (either  alone  or  upon  the  occurrence  of  any
additional  or subsequent  event) will or may result in any payment  (whether of
severance  pay or  otherwise),  "parachute  payment" (as such term is defined in
Section 280G of the Code), acceleration,  vesting or increase in benefits to any
employee  or  former  employee  or  director  of  the  Company  or  any  of  its
subsidiaries.  No Employee  Benefit Plan  provides for the payment of severance,
termination, change in control or similar-type payments or benefits.

               (i)  DOCUMENTS.  The  Company  have  delivered  or  caused  to be
delivered  to the  Investor  or its  counsel  true and  complete  copies  of the
following  documents  in  connection  with each  Employee  Benefit  Plan  (where
applicable):  (i) all  Employee  Benefit  Plans as in effect on the date hereof,
together with all  amendments  thereto,  including,  in the case of any Employee
Benefit Plan not set forth in writing, a written description  thereof;  (ii) all
current  summary plan  descriptions,  summaries of material  modifications,  and
material  communications;  (iii) all current trust  agreements,  declarations of
trust and other  documents  establishing  other  funding  arrangements  (and all
amendments thereto and the latest financial statements  thereof);  (iv) the most
recent IRS determination letter,  obtained with respect to each Employee Benefit
Plan intended to be qualified  under Section  401(a) of the Code or exempt under
Section  501(a) of the Code;  (v) the annual report on IRS Form  5500-series  of
each of the last three years for each


                                      -10-
<PAGE>


Employee  Benefit  Plan  required  to file  such  form;  (vi) the most  recently
prepared financial statements; (vii) all service provider agreements,  insurance
contracts,  annuity contracts,  investment management  agreements,  subscription
agreements,   participation   agreements,   and  recordkeeping   agreements  and
collective  bargaining  agreements;  and  (viii)  the most  recent  response  to
auditors' reports for each Employee Benefit Plan.

          2.14   TAXES.

               (a) The Company and its subsidiary  have filed all Federal income
tax returns and all other tax returns  and reports  (whether  foreign,  state or
local)  required  to be filed by them,  the failure of which to file could have,
individually or in the aggregate,  a Material  Adverse Effect.  All such returns
are  complete  and  correct  in all  material  respects.  The  Company  and  its
subsidiary  have paid all taxes due for the periods for which such  returns were
filed and all material  taxes for which no return was required to be filed,  and
the most recent financial  statements  contained in the SEC Documents reflect an
adequate reserve for all taxes payable by the Company and its subsidiary for all
taxable  periods  and  portions  thereof  through  the  date of  such  financial
statements.

               (b) No material  deficiencies  for any taxes have been  proposed,
asserted or assessed against the Company or its subsidiary,  and no requests for
waivers  of  the  time  to  assess  any  such  taxes  are  pending.  No  written
notification  of intention to examine has been  received  from,  and to the best
knowledge of the Company, no tax return of the Company is being examined by, the
United States Internal Revenue Service or any other taxing authority with regard
to Taxes.  The Federal income tax returns of the Company and its subsidiary have
been properly and timely filed with the Internal  Revenue  Service for all years
through 1997.

               (c) As used in this Agreement, "Taxes" shall include all Federal,
state,  local and  foreign  income,  property,  sales,  excise and other  taxes,
tariffs or  governmental  charges  of any nature  whatsoever. 

               (d) Neither the Company nor its  subsidiary  is a "real  property
holding corporation" as defined in the Code.

          2.15 PERMITS;  ENVIRONMENTAL  MATTERS.  The Company and its subsidiary
have  accrued or otherwise  provided,  in  accordance  with  generally  accepted
accounting  principles,  consistently  applied,  for all  damages,  liabilities,
penalties  or costs that it may incur in  connection  with any claim  pending or
threatened  against  them,  or any  requirement  that is or may be applicable to
them,  under any  Environmental  Laws,  and such  accrual or other  provision is
reflected  in the  Company's  most recent SEC  Financial  Statements,  except as
disclosed in Schedule 2.15, which disclosed items could not,  individually or in
the  aggregate,  reasonably be expected to have a Material  Adverse  Effect with
respect to the Company or its subsidiary:

               (a) The Company and its  subsidiary  are in  compliance  with all
applicable laws, rules, regulations,  ordinances,  orders decrees and common law
relating to


                                      -11-
<PAGE>


contamination,  pollution or the  protection or human health or the  environment
("Environmental  Laws"),  and the Company and its  subsidiary  has all  permits,
licenses,  registrations and other  governmental  authorizations  required under
such  laws  ("Environmental  Permits")  for their  operations,  and there are no
violations,  investigations  or  proceedings  pending  or, to the  knowledge  of
Company or its subsidiary, threatened with respect to Environmental Laws or such
Environmental  Permits  except  where the  failure  to have  such  Environmental
Permits or where the violation,  investigation  or proceeding  relating  thereto
would not,  individually or in the aggregate,  have a Material Adverse Effect on
the Company or its subsidiary.

               (b) No notice,  notification,  demand,  request for  information,
citation,  summons, complaint or order is pending or has been received by or, to
the  knowledge of the Company or its  subsidiary,  is  threatened  by any person
against the Company or its subsidiary under any Environmental Laws or in respect
of any of the  properties  or  facilities  now or  previously  owned,  leased or
operated by the Company or its subsidiary.  No penalty has been assessed against
the  Company or its  subsidiary,  and no  liability  has been  imposed  upon the
Company or its subsidiary,  under  Environmental Law with respect to any alleged
notification,  demand, request for information,  citation, summons, complaint or
order except where such matters have been fully  resolved,  or where  resolution
would not,  individually or in the aggregate,  have a Material Adverse Effect on
the Company or its subsidiary or prevent or materially delay the consummation of
the transactions contemplated by this Agreement.

               (c) No hazardous, toxic or regulated substance,  waste, materials
or chemical  ("Hazardous  Substance") has been discharged,  generated,  treated,
manufactured,  handled, stored, transported,  emitted, released or is present at
any property now or previously  owned,  leased or operated by the Company or its
subsidiary in violation of any  Environmental Law or under  circumstance  which,
individually or in the aggregate, would have in a Material Adverse Effect on the
Company or its subsidiary.

          2.16   CONTRACTS; DEBT INSTRUMENTS.

               (a) Except as  disclosed in both the SEC  Documents  and Schedule
2.16(a),  there is no contract or  agreement  that is material to the  business,
financial  condition or results of operations of the Company and its subsidiary.
Neither the Company nor its  subsidiary  is in violation of or in default  under
(nor does there exist any condition which upon the passage of time or the giving
of notice,  or both,  would cause such a violation of or default under) any loan
or credit  agreement,  note,  bond,  mortgage,  indenture,  lease,  or any other
contract, agreement,  arrangement or understanding, to which they are a party or
by which  they or any of their  properties  or  assets  are  bound,  except  for
violations  or  defaults  that  could  not,  individually  or in the  aggregate,
reasonably be expected to result in a Material Adverse Effect.

               (b) Set forth on Schedule  2.16(b) of the Agreement is (i) a list
of all loan or credit agreements, notes, bonds, mortgages,  indentures and other
agreements and instruments  pursuant to which any indebtedness of the Company or
its  subsidiary  in an  aggregate


                                      -12-
<PAGE>


principal  amount in excess of $100,000 is  outstanding  or may be incurred  and
(ii) the respective  principal amounts  currently  outstanding  thereunder.  For
purposes of this Section 2.16,  "indebtedness"  shall mean,  with respect to any
person,  without  duplication,  (A) all  obligations of such person for borrowed
money,  or with respect to deposits or advances of any kind to such person,  (B)
all obligations of such person evidenced by bonds, debentures,  notes or similar
instruments,  (C) all obligations of such person upon which interest charges are
customarily  paid, (D) all obligations of such person under  conditional sale or
other title retention  agreements relating to property purchased by such person,
(E) all  obligations  of such person issued or assumed as the deferred  purchase
price of property or services (excluding obligations of such person to creditors
for raw  materials,  inventory,  services and supplies  incurred in the ordinary
course of such person's business), (F) all capitalized lease obligations of such
person,  (G) all obligations of others secured by any Lien on property or assets
owned or acquired by such person, whether or not the obligations secured thereby
have been assumed,  (H) all  obligations  of such person under  interest rate or
currency hedging transactions (valued at the termination value thereof), (I) all
letters of credit  issued for the account of such person  (excluding  letters of
credit  issued for the  benefit of  suppliers  to  support  accounts  payable to
suppliers  incurred in the ordinary  course of business) and (J) all  guarantees
and arrangements having the economic effect of a guarantee of such person of any
indebtedness of any other person.

               (c) Set forth on Schedule  2.16(c) of this Agreement is a list of
all of the contracts,  agreement,  leases, subleases,  licenses or other similar
arrangements or understandings to which the Company or its subsidiary is a party
which involve payments of more than $50,000 in any one year.

          2.17 TITLE TO PROPERTIES.  The Company and its  subsidiary  have good,
valid and  marketable  title  to, or valid  leasehold  interests  in,  all their
material  properties  and assets except for such as are no longer used or useful
in the conduct of their  businesses  or as have been disposed of in the ordinary
course of  business  and except for  defects  in title,  easements,  restrictive
covenants and similar  encumbrances or impediments that,  individually or in the
aggregate,  do not and will not have a Material  Adverse Effect on their ability
to conduct their businesses as currently conducted. All such material properties
and  assets,  other  than  properties  and  assets in which the  Company  or its
subsidiary has leasehold interests,  are free and clear of all Liens, except for
Liens  that,  in the  aggregate,  could not  reasonably  be  expected  to have a
Material  Adverse  Effect on the  ability of the  Company or its  subsidiary  to
conduct  business as currently  conducted.  The Company and its subsidiary  have
complied in all material respects with the terms of all leases to which they are
a party and under which they are in  occupancy,  and all such leases are in full
force and effect.  The Company and its subsidiary enjoy peaceful and undisturbed
possession under all such leases.

          2.18   INTELLECTUAL   PROPERTY.   For  purposes  of  this   Agreement,
"Intellectual  Property"  shall mean all  industrial and  intellectual  property
rights,  including without  limitation,  patents,  patent  applications,  patent
rights, trademarks,  trademark applications, trade names, service marks, service
mark applications, trade mark registrations, copyrights, copyright 


                                      -13-
<PAGE>


applications,  copyright registrations,  technology,  know-how,  licenses, trade
secrets,  proprietary processes and formulae owned or licensed by the Company or
its subsidiary.  A complete list of the Intellectual Property of the Company and
its subsidiary is set forth on Schedule 2.18 to this  Agreement.  The Company or
its  subsidiary  owns, is licensed by the owner or otherwise  holds the right to
use and  enjoy  the  rights  under  the  Intellectual  Property  as set forth in
Schedule  2.18,  except where the lack of ownership,  license or right to use or
enjoy the  rights  under the  Intellectual  Property  could  not  reasonably  be
expected to have,  individually or in the aggregate,  a Material  Adverse Effect
and the consummation of the transactions contemplated by this Agreement will not
alter or impair any such rights. Except as set forth in Schedule 2.18, no claims
have been asserted by any person or Governmental Entity alleging that any of the
current or  contemplated  activities of the Company or its  subsidiary  infringe
upon or violate any patent,  copyright,  trademark,  trade name, trade secret or
other proprietary right of any third party. No person or Governmental Entity has
undertaken a judicial  challenge or  judicially  questioned  the validity of the
Intellectual  Property set forth in Schedule  2.18 or the  effectiveness  of any
license or agreement  relating thereto to which the Company or its subsidiary is
a party  and  which,  individually  or in the  aggregate,  could  reasonably  be
expected to have a Material Adverse Effect.

          2.19 CERTAIN  AGREEMENTS.  Except as set forth in Schedule  2.19,  the
Company  is not a party  to,  or  bound  by,  any  contract  or  agreement  that
materially  limits the ability of the Company  directly or indirectly to compete
in any line of  business  or with any person in any  geographic  area during any
period of time.

          2.20 INDEMNIFICATION  CLAIMS. There are no indemnification,  breach of
contract or similar claims by or against the Company or its subsidiary which are
filed or pending,  and, to the best knowledge of the Company and its subsidiary,
there are no indemnification, breach of contract or similar claims by or against
the Company or its subsidiary threatened,  in each case in excess of $100,000.00
in amount.

          2.21 ANTITAKEOVER  STATUTE;  SHAREHOLDER  PROTECTION RIGHTS AGREEMENT.
The Board of Directors of the Company has taken all action  necessary to approve
the  acquisition  of shares of Series D  Preferred  Stock by  Investor  and each
Purchaser  pursuant to this Agreement (which shares represent 15% or more of the
voting  stock of the  Company)  in  accordance  with  and  pursuant  to  Section
203(a)(1) of the DGCL. The actions taken by the Company are sufficient to comply
with  Section  203(a)(1)  of the DGCL  and  will  result  in  Investor  and each
Purchaser  being exempted from the  restriction  set forth in Section 203 of the
DGCL.  The Board of Directors  of the Company has taken all action  necessary in
accordance with the Shareholder  Protection Rights Agreement dated September 15,
1997,  between the Company and the American  Stock Transfer & Trust Company (the
"Shareholder  Protection Rights  Agreement") to guarantee that none of the stock
purchase  rights  distributed  pursuant  to the  Shareholder  Protection  Rights
Agreement  are or  will  become  exercisable  as a  result  of the  transactions
contemplated by the Documents.


                                      -14-
<PAGE>


          2.22  PROTECTIVE  AGREEMENTS.  Schedule 2.22 hereto contains a list of
all directors, officers and employees of the Company or its subsidiary that have
entered into the standard form of Non-Competition  Agreement (the "NCA") and the
standard form of Non-Disclosure  Agreement (the "NDA" and together with the NCA,
the "Protective  Agreements"),  with the Company or its subsidiary,  as the case
may be, copies of which have been provided  previously to Investor.  Each of the
Protective  Agreements is (i) in full force and effect;  and (ii) enforceable by
the Company against the respective director,  officer or employee who is a party
thereto  in  accordance  with its  terms,  except  that the  remedy of  specific
performance and injunctive and other forms of equitable relief may be subject to
equitable defenses,  if any, and to the discretion of the court before which any
proceeding  therefor may be brought.  No breach of or event of default under any
Protective  Agreement  has  occurred  or is  continuing  with  respect  to  each
director,  officer or employee who is a party to a Protective  Agreement and the
Company  has not waived any  defenses  nor allowed any defense to lapse or toll.


          2.23 OTHER AGREEMENTS  CONTAINING  NON-DISCLOSURE AND  NON-COMPETITION
PROVISIONS.  

               (a) Schedule 2.23 attached  hereto  contains a true,  correct and
complete list of all persons  (other than  directors,  officers and employees of
the Company or its subsidiary) who have entered into agreements with the Company
or its subsidiary  containing  mutual  confidentiality  and non-use  agreements,
mutual  non-disclosure   agreements,   and  non-disclosure   agreements,   which
provisions,  individually  or in the  aggregate,  have  not  had,  and  are  not
reasonably  expected to have,  a Material  Adverse  Effect.  The Company and its
subsidiary hereby represent and warrant that the Company and its subsidiary have
entered into agreements with all persons with whom the Company or its subsidiary
has shared,  disclosed or otherwise made available its confidential  information
(as defined  below)  pursuant to which such persons are bound  contractually  to
protect from disclosure and keep  confidential  such  information and not to use
any such  confidential  information  for any purpose except as set forth in such
agreements.  Each  such  agreement  is (i) in full  force and  effect;  and (ii)
enforceable by the Company or its subsidiary  against each respective person who
is a party  thereto  in  accordance  with its terms,  except  that the remedy of
specific  performance and injunctive and other forms of equitable  relief may be
subject to equitable defenses, if any, and to the discretion of the court before
which any  proceeding  therefor  may be  brought.  No breach or event of default
under any such  agreement  has  occurred or is  continuing  with respect to each
person who is a party  thereto and the Company has not waived any  defenses  nor
allowed  any  defense  to lapse or toll.  For  purposes  of this  Section  2.23,
"confidential  information"  shall mean the Company's or its subsidiary's  trade
secrets, business plans, technology,  procedures,  manuals, confidential reports
and communications,  lists of potential  customers and clients,  any information
and materials  received by the Company or its  subsidiary  from third parties in
confidence  (or  subject to  non-disclosure  or similar  covenants),  production
processes,  product  designs,  marketing  techniques and  arrangements,  mailing
lists, purchasing information,  pricing policies, quoting procedures,  financial
information,  customer and prospect names and requirements,  employee, customer,
supplier and distributor data and other materials or information relating to the
Company's


                                      -15-
<PAGE>


business  and  activities  and the manner in which the  Company  does  business,
discoveries,  concepts, and ideas, including, without limitation, the nature and
results of research and development activities, processes, formulas, inventions,
techniques and  "know-how,"  any other  materials or information  related to the
business or activities  of the Company  which are not generally  known to others
engaged in similar businesses or activities and all ideas which are derived from
or relate to the Company's  access to any of the above  mentioned  materials and
information.

               (b) Neither the Company nor its subsidiary has nor shall disclose
any confidential information of the Company or its subsidiary except pursuant to
those  non-disclosure  and  non-competition  provisions  described above in this
Section 2.23 or in Section 2.22, or as otherwise may be required to be disclosed
by applicable law; provided,  however, to the extent possible, the Company shall
use its best efforts to avoid such  disclosures  consistent with the exercise of
reasonable business judgment.

          2.24 PATENTS.  The Company has an exclusive worldwide license to make,
have made,  use,  sell and have sold the subject  matter which is disclosed  and
claimed  in  U.S.  Patent  Nos.  4,666,897  entitled   Inhibition  of  Mammalian
Collagenolytic   Enzymes  by  Tetracycline,   and  Re  34,656  entitled  Use  of
Tetracycline  to  Enhance  Bone  Protein  Synthesis  and/or  Treatment  of  Bone
Deficiency.  The license to the above patents was granted pursuant to the option
exercised  by the  Company  in its  September  6, 1995  letter  to the  Research
Foundation of the State University of New York, (the "Foundation"),  said option
being  granted  pursuant  to the option  granted  by the  Amended  and  Restated
Agreement between the Company and the Foundation, effective January 13, 1992, as
amended by the Addendum to Amended and Restated Agreement,  dated April 1, 1996,
and the Second Addendum to the Amended and Restated  Agreement,  dated April 18,
1996  (individually and collectively the "Patent  Agreements").  The Company has
not,  to the  best  of its  knowledge,  breached  any  provision  of the  Patent
Agreements  and to the best  knowledge of the Company there has been no event of
default or claim brought under any of the Patent Agreements.  Each of the Patent
Agreements  is in full  force and effect and is  enforceable  by the  Company in
accordance  with its  respective  terms and may be assigned by the  Company,  in
whole or in part, without the consent of any other person.

          2.25 RELATED TRANSACTIONS. No current or former stockholder, director,
officer or employee of the Company (other than Investor and  Purchasers) nor any
relative or  "associate"  (as defined in the rules and  regulations  promulgated
under the Exchange Act) of any such Person, is presently, directly or indirectly
through his or its affiliation  with any other person or entity,  a party to any
transaction  with the Company  providing for the  furnishing of services  (other
than  employment  of such  individuals  by the Company) by or to, or the sale of
products  by or to,  or  rental  of real or  personal  property  from or to,  or
otherwise  requiring  cash  payments  by or to, any such  Person in excess of an
aggregate of $60,000. For purposes of this Agreement,  a transaction of the type
described in this Section  2.25 is  sometimes  herein  referred to as a "Related
Transaction."


                                      -16-
<PAGE>


          2.26 AMENDMENTS TO CERTIFICATE OF INCORPORATION. Prior to the Closing,
the Board of  Directors  of the Company and its  subsidiary  will have taken all
actions  necessary  to adopt  the  resolutions  set  forth in  Exhibit A to this
Agreement,  and the  Company  will  have  filed a  Certificate  of  Designation,
Preferences and Rights of Series D Cumulative Convertible Preferred Stock in the
form of Exhibit A hereto (the  "Certificate of Designation" ) with the Secretary
of State of the State of Delaware.

          2.27  PUBLIC  ANNOUNCEMENTS.  The  Company  and its  subsidiary  shall
consult  with  Investor  and obtain the prior  approval  and consent of Investor
before issuing any press release or otherwise  making any public  statement with
respect to the transactions  contemplated  hereby,  except as may be required by
law,  in which  case the  Company  or its  subsidiary  shall use its good  faith
efforts to review the contents of any such announcement with Investor and obtain
the approval and consent of Investor reasonably in advance of the public release
of such announcement.

          2.28 USE OF PROCEEDS.  The net  proceeds  received by the Company from
the sale of the shares of Series D Preferred Stock contemplated  herein shall be
used by the Company:  (i) to repay in full principal and unpaid accrued interest
of that certain 12% Senior Secured  Convertible Note due March 18, 2000,  issued
by the Company in favor of Investor pursuant to the terms and conditions of that
certain Convertible Loan and Security Agreement,  by and between the Company and
Investor,  of even date herewith and (ii) for working  capital and other general
corporate purposes.

          2.29 S-8 AMENDMENT. No future amendment by the Company of its Form S-8
(Registration  Statement  No.  333-31229)  with respect to the  registration  of
shares on behalf of officers of the Company  (the "S-8  Amendment")  shall have,
individually or in the aggregate,  a Material Adverse Effect on the transactions
contemplated  by this  Agreement,  and the total number of shares subject to the
S-8  Amendment  shall  at no  time  exceed  Two  Hundred  Twenty-Seven  Thousand
(227,000)  shares.  The Company  shall cause any  directors  and officers of the
Company who would  otherwise be entitled to sell shares of Common Stock pursuant
to such S-8 Amendment to enter into an agreement  with the Company,  in form and
substance  reasonably  acceptable  to Investor  and the  Company,  whereby  such
directors and officers  shall be precluded  from selling shares in excess of the
amounts that they would  otherwise be entitled to sell in  accordance  with Rule
144(e) promulgated under the Securities Act.

          2.30 DISCLOSURE.  No representation or warranty by the Company in this
Agreement,  and no  exhibit,  document,  statement,  certificate  or Schedule or
written  information  furnished by the Company or to be furnished by the Company
to Investor pursuant hereto, or in connection with the transactions contemplated
hereby,  contains or will contain any untrue  statement of a material  fact,  or
omits or will omit to state a material fact  necessary to make the statements or
facts contained herein or therein not misleading.


                                      -17-
<PAGE>


                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES
                           OF INVESTOR AND PURCHASERS
                           --------------------------

          Investor  and  each  Purchaser,  severally  and  not  jointly,  hereby
represent  and warrant as to itself,  himself or herself  only to the Company as
follows:

3.1   ORGANIZATION.

               (a) Investor is a limited  partnership  duly  organized,  validly
existing  and in good  standing  under the laws of the State of Delaware and has
the requisite power to carry on its business as it is now being conducted.

               (b) Each  Purchaser is duly  organized,  validly  existing and in
good  standing  under  the  laws of the  state of its  organization  and has the
requisite power to carry on its business as it is now being conducted. Exhibit C
sets forth the state of organization of each Purchaser.

          3.2 AUTHORITY  RELATIVE TO THIS AGREEMENT;  NO CONFLICT.  Investor and
each Purchaser has the requisite power and authority to execute and deliver this
Agreement and to consummate  the  transactions  contemplated  hereby without the
consent of any other person  (except for such consents as have  heretofore  been
obtained).  This  Agreement has been duly and validly  executed and delivered by
Investor and each Purchaser and, assuming this Agreement constitutes a valid and
binding  obligation  of the  Company,  this  Agreement  constitutes  a valid and
binding agreement of Investor and each Purchaser,  enforceable  against Investor
and each Purchaser in accordance with its terms,  and will not conflict with any
other agreement to which Investor or such Purchaser is a party.

          3.3 INVESTMENT  INTENT.  The shares of Series D Preferred  Stock being
purchased by Investor  and each  Purchaser  are being  purchased by Investor and
each Purchaser for  investment  for its, his or her own account,  and not with a
view to any  distribution  thereof that would violate the Securities Act, or the
applicable state securities laws of any state.  Investor and each Purchaser will
not distribute the shares of Preferred  Stock in violation of the Securities Act
or the applicable securities laws of any state. Investor and each Purchaser will
not  "sell  short"  the  Common  Stock of the  Company,  but  Investor  and each
Purchaser  may purchase the  Company's  Common Stock in the open market for long
term investment purposes and as to such purchases,  if any, the Company makes no
representations or warranties.

          3.4 PURCHASERS' COUNSEL. Each Purchaser hereby represents and warrants
on its own behalf that such  Purchaser  is not  represented  by Dechert  Price &
Rhoads or Buchanan Ingersoll Professional Corporation.


                                      -18-
<PAGE>


          3.5  ECONOMIC  RISK.  Investor  and each  Purchaser  is well versed in
financial  matters,  has had extensive dealings over the years in securities and
is fully  familiar  with the  operating  history  and  financial  results of the
Company and is fully capable of understanding  the type of investment being made
pursuant  to this  Agreement  and the risks  involved in  connection  therewith.
Investor and each Purchaser is  financially  able to hold the Series D Preferred
Stock for  long-term  investment,  believes  that the  nature  and amount of the
Series D Preferred  Stock being acquired by Investor and each such Purchaser are
consistent with Investor's and each Purchaser's  overall  investment program and
financial position,  and recognizes that there are substantial risks involved in
the acquisition of the Series D Preferred Stock.

          3.6 ADDITIONAL REPRESENTATIONS. Investor and each Purchaser: (i) is an
accredited  investor within the meaning of Rule 501(a) under the Securities Act,
(ii) is aware of the  limits on resale  imposed  by virtue of the  nature of the
transactions  contemplated by this Agreement and is aware that the  certificates
representing  such  Investor's or Purchaser's  respective  ownership of Series D
Preferred Stock will bear related  restrictive  legends;  (iii) is acquiring the
shares of the Company hereunder without registration under the Securities Act in
reliance on the  exemption  from  registration  contained in Section 4(2) of the
Securities  Act;  (iv) has been given the  opportunity  to ask questions of, and
receive  answers from,  the officers of the Company  regarding the Company,  its
current and proposed  business  operations and the Series D Preferred Stock, and
the  officers of the Company  have made  available to the Investor and each such
Purchaser  all  documents  and  information  that the  Investor  and  each  such
Purchaser has requested relating to an investment in the Company; (v) has access
to all of  the  Company's  public  filings  with  the  Securities  and  Exchange
Commission;  (vi)  acknowledges that the Company is entering into this Agreement
in  reliance  upon  Investor's  and each such  Purchaser's  representations  and
warranties  and other  covenants  and  agreements  contained  herein;  and (vii)
acknowledges  that Investor and each of the  Purchasers,  as the case may be, is
entering  into this  Agreement in reliance  upon  Investor's  or each such other
Purchaser's,  as the case  may be,  representations  and  warranties  and  other
covenants and agreements contained herein.

                                  ARTICLE III-A

                                    COVENANTS
                                    ---------

          3A.1  Conduct of Business of the  Company.  During the period from the
date of execution of this  Agreement  to the Closing  Date,  the Company and its
subsidiary will each conduct its operations  according to its ordinary and usual
course of business  and  consistent  with past  practice.  Without  limiting the
generality of the foregoing,  and except as otherwise expressly provided in this
Agreement,  neither  the  Company nor its  subsidiary  shall,  without the prior
written consent of the Investor:

               (a) issue,  sell or pledge, or authorize or propose the issuance,
sale or pledge of:


                                      -19-
<PAGE>


                    (i)  additional  shares of capital  stock of any  class,  or
securities convertible into any such shares, or any rights,  warrants or options
to  acquire  any  such  shares  or  other  convertible  securities,  or grant or
accelerate  any right to convert or exchange any  securities  of the Company for
shares,  other than shares of Common Stock issuable pursuant to the terms of any
option  grants under the  Company's  current  stock option plans or  commitments
disclosed in Section 2.4(d) and Section 2.13 hereof, or

                    (ii) any other  securities  in respect  of, in lieu of or in
substitution for shares of Common Stock outstanding on the date thereof;

               (b)  purchase  or  otherwise  acquire,  or propose to purchase or
otherwise  acquire,  any of its  outstanding  capital stock or other equity debt
securities;

               (c) declare or pay any dividend or  distribution on any shares of
capital stock of the Company;

               (d)  enter  into  any  merger  or   consolidation   or  make  any
acquisition  of a  material  amount  of assets or  securities,  any  disposition
(including by way of mortgage,  license,  encumbrance or any Lien) of a material
amount of assets or securities,  or enter into a material  contract,  not in the
ordinary  course of  business,  consistent  with past  practice,  or  release or
relinquish any material  contract rights not in the ordinary course of business,
consistent with past practice, or make any amendments, or modifications thereto;

               (e) (i) incur any  indebtedness  for borrowed  money or guarantee
any such  indebtedness of another  person,  issue or sell any debt securities or
warrants or other  rights to acquire any debt  securities  of the Company or its
subsidiary,  guarantee  any debt  securities of another  person,  enter into any
"keep well" or other agreement to maintain any financial  statement condition of
another person or enter into any  arrangement  having the economic effect of any
of the foregoing;  or (ii) make any loans, advances of capital contributions to,
or investments in, any other person;

               (f) pay, discharge,  settle or satisfy any claims, liabilities or
obligations   (absolute,   accrued,   asserted  or  unasserted,   contingent  or
otherwise),  other than the payment, discharge,  settlement or satisfaction,  in
the ordinary  course of business  consistent with past practice or in accordance
with  their  terms,  of  liabilities   reflected  or  reserved  against  in,  or
contemplated by, the most recent consolidated financial statements (or the notes
thereto) of the Company included in the SEC Documents filed prior to the date of
this Agreement or incurred  since the date of such  financial  statements in the
ordinary course of business consistent with past practice;

               (g)  propose  or  adopt  any  amendments  to the  Certificate  of
Incorporation,  as  amended,  or  Bylaws  of the  Company  (or any such  similar
organizational documents of its subsidiary), except as contemplated hereby;


                                      -20-
<PAGE>


               (h) enter into any new employment  agreements  with any officers,
directors or key employees or grant any material  increases in the  compensation
or benefits to officers, directors and key employees;

               (i) take any of the actions set forth in Section 2.6  (Absence of
Certain Changes) not otherwise specified herein;

               (j) settle the terms of any  material  litigation  affecting  the
Company or its subsidiary;

               (k) make any tax election or settle or compromise  any income tax
liability;

               (l)  make or agree to make  any new  capital  expenditures  which
individually  are in excess of $300,000 or which in the  aggregate are in excess
of $300,000; or

               (m) agree in writing or  otherwise  to take any of the  foregoing
actions or any action  which would make any  representation  or warranty in this
Agreement untrue or incorrect.

          3A.2 EXISTENCE; MAINTENANCE OF PROPERTY. Between the date of execution
of this Agreement and the Closing Date, the Company and its subsidiary  shall do
or cause to be done all things  necessary  to  preserve,  renew and keep in full
force and effect its respective corporate existence,  material rights, licenses,
permits and  franchises and comply with all laws and  regulations  applicable to
the conduct of its  respective  business  and the  ownership  of its  respective
property;  at all times maintain and preserve all material property necessary in
the conduct of the business and keep the same in good repair,  working order and
condition,  and from time to time  make,  or cause to be made,  all  needed  and
proper repairs,  renewals and replacements thereto, so that the business carried
on in connection therewith may be properly conducted at all times.

            3A.3 NO SOLICITATION. On or before the Closing Date, the Company and
its subsidiary  shall not, nor shall the Company or its subsidiary  authorize or
permit any officer,  director or employee of or any investment banker,  attorney
or other advisor or representative of the Company or its subsidiary to, directly
or indirectly,  solicit,  initiate or encourage  (including by way of furnishing
confidential  or  non-public  information  with  respect to the  business of the
Company or its  subsidiary or permitting  access to the assets and properties or
books and records of the Company or its subsidiary),  receive, negotiate, assist
or otherwise facilitate any offers or inquiries from any person or entity, other
than Investor or its affiliates, concerning any proposal that constitutes or may
reasonably be expected to lead to any direct or indirect acquisition or takeover
proposal or any  financing  of the  business  of the Company or its  subsidiary,
other than trade  financing in the ordinary  course of business  consistent with
past practice.


                                      -21-
<PAGE>


          3A.4 ACCESS TO INFORMATION. Between the date of execution of this
Agreement and the Closing Date, the Company will upon reasonable notice (i) give
Investor and its authorized representatives access during regular business hours
to all of the Company's plants, offices,  warehouses and other facilities and to
all books and records of it, (ii) permit Investor to make such inspections as it
may require (and the Company shall  cooperate with Investor in any  inspections,
including, without limitation, environmental due diligence), and (iii) cause its
officers and those of its subsidiary to furnish Investor with such financial and
operating data and other information with respect to the business and properties
of the Company and its  subsidiary  as Investor  may from time to time  request.
Investor shall maintain the  confidentiality of any confidential and proprietary
information  so  obtained  by it which is not  otherwise  available  from  other
sources that are free from similar  restrictions;  provided,  however,  that the
foregoing shall in no way limit or otherwise restrict the ability of Investor or
such authorized  representatives to disclose any such information concerning the
Company  or its  subsidiary  which it may be  required  to  disclose  (a) to its
partners,  board members or stockholders,  to the extent required to satisfy its
fiduciary  obligations  to such  persons,  or (b)  otherwise  pursuant  to or as
required by law.

          3A.5  PROXY  STATEMENT  AND  STOCKHOLDER   MEETING.   As  promptly  as
practicable after the execution and delivery of this Agreement, the Company will
prepare  and file  with the SEC  preliminary  proxy  materials  relating  to the
adoption of this  Agreement  and the approval of the  transactions  contemplated
hereby by the  stockholders  of the Company.  As promptly as  practicable  after
comments  are  received  from the SEC on the  preliminary  proxy  material,  the
Company will file with the SEC the definitive Proxy  Statement.  As used herein,
"Proxy  Statement"  means the letter to stockholders,  notice of meeting,  proxy
statement and form of proxy (and any schedule  required to be filed with the SEC
in connection  therewith) to be  distributed to  stockholders  of the Company in
connection  with the Stockholder  Meeting (as defined  below).  The Company will
make all necessary filings with respect to the transactions contemplated by this
Agreement  under  the  Securities  Act,  the  Exchange  Act  and the  rules  and
regulations  thereunder,  and applicable state securities laws, and will use all
reasonable  efforts to obtain any required  approvals or clearances with respect
thereto.  The Proxy  Statement will include the  recommendation  of the Board of
Directors  of  the  Company  in  favor  of  the  approval  of  the  transactions
contemplated hereby.

          3A.6 NASDAQ  LISTING.  Between the date of execution of this Agreement
and  the  Closing  Date,  the  Company  shall  take  all  actions  necessary  or
appropriate  to ensure that the shares of Common Stock are listed or  authorized
to be quoted on NASDAQ or listed on any  national  securities  exchange on which
shares of Common  Stock are then listed and the  Company  shall take all actions
necessary or  appropriate  to ensure that it  maintains a public  market for its
Common  Stock on the  American  Stock  Exchange,  NASDAQ  or the New York  Stock
Exchange ("NYSE").

          3A.7   REASONABLE BEST EFFORTS.


                                      -22-
<PAGE>


               (a)  Subject  to the terms  and  conditions  herein,  each of the
parties hereto agrees to use its reasonable best efforts to take, or cause to be
taken,  all  appropriate  action,  and to do,  or cause to be done,  all  things
necessary,  proper  or  advisable  under  applicable  laws  and  regulations  to
consummate and make effective the  transactions  contemplated by this Agreement.
In case at any time  after  Closing  Date any  further  action is  necessary  or
desirable to carry out the purposes of this  Agreement,  the proper officers and
directors of each party to this Agreement shall take all such necessary  action.
Such  reasonable  best  efforts  shall  include,  without  limitation,  (i)  the
obtaining of all necessary consents, approvals or waivers from third parties and
governmental  authorities  necessary  to the  consummation  of the  transactions
contemplated  by this  Agreement,  and (ii) opposing  vigorously,  to the extent
commercially reasonable, any litigation or administrative proceeding relating to
this  Agreement or the  transactions  contemplated  hereby,  including,  without
limitation,  to the  extent  commercially  reasonable,  promptly  appealing  any
adverse  court or  agency  order.  Notwithstanding  the  foregoing  or any other
provisions contained in this Agreement to the contrary, neither Investor nor any
of its  affiliates  shall be under any  obligation of any kind to enter into any
negotiations or to otherwise agree with any Governmental  Entity,  including but
not limited to any governmental or regulatory  authority with  jurisdiction over
the enforcement of any applicable  federal,  state, local and foreign antitrust,
competition  or other  similar  laws,  or any other  party to sell or  otherwise
dispose of, hold separate  (through the  establishment  of a trust or otherwise)
particular  assets or  categories of assets or businesses of any of the Company,
Investor or any of Investor's affiliates.

               (b) Between the execution of this Agreement and the Closing Date,
the  Company  shall  give and make  all  required  notices  and  reports  to the
appropriate  persons  with  respect  to the  Environmental  Permits  that may be
necessary for the consummation of the transactions contemplated hereby.

               (c) Between the execution of this Agreement and the Closing Date,
the Company and its Board of  Directors  shall (i) take all action  necessary to
ensure that no state  takeover  statute or similar  statute or  regulation is or
becomes  applicable to this  Agreement or any of the  transactions  contemplated
hereby,  and (ii) if any state takeover statute or similar statute or regulation
becomes  applicable to this  Agreement or any of the  transactions  contemplated
hereby,  take all action necessary to ensure that the transactions  contemplated
by this  Agreement may be  consummated  as promptly as  practicable on the terms
contemplated  by this  Agreement  and  otherwise  to minimize the effect of such
statute or regulation on the transactions  contemplated by this Agreement.  

          3A.8  STOCKHOLDER  LITIGATION.  Between the date of  execution of this
Agreement and the Closing Date, the Company shall give Investor the  opportunity
to  participate  in the  defense or  settlement  of any  stockholder  litigation
against  the  Company  and its  directors  relating  to any of the  transactions
contemplated  by this Agreement until Closing.  Thereafter,  with regard to such
stockholder litigation that commences after the date of execution but before the
Closing of this  Agreement,  the Company shall give Investor the  opportunity to
participate  in the  defense


                                      -23-
<PAGE>


of such  litigation,  and if settlement of such litigation could have a Material
Adverse Effect,  then no such settlement  shall be agreed to without  Investor's
consent,  which  consent shall not be  unreasonably  withheld.  In addition,  no
settlement  requiring  a payment by a director  shall be agreed to without  such
director's consent, which consent shall not be unreasonably withheld.

          3A.9  FINANCIAL  REPORTS.  Between  the  date  of  execution  of  this
Agreement  and the Closing Date,  the Company  shall  furnish  Investor with the
following: 

               (a) PERIODIC  REPORTS.  As soon as  practicable,  and in any case
within  thirty (30)  calendar  days after the end of each  calendar  month,  the
Company shall furnish Investor with monthly unaudited financial  statements (all
prepared  in  accordance   with   generally   accepted   accounting   principles
consistently  applied),  including (A) an unaudited balance sheet as of the last
day of such month, (B) an unaudited statement of income for such month, together
with a  cumulative  statement  of income from the first day of the then  current
fiscal year to the last day of such month,  (C) a cash flow  statement  for such
month,  together  with a cash  flow  statement  from the  first  day of the then
current  fiscal year to the last day of such month,  (D) a schedule  showing all
prescription  data known to the Company on new and existing users,  (E) an aging
schedule (or summary thereof) of all accounts  receivable and accounts  payable,
and (F) a comparison  between the actual figures for such month,  the comparable
figures  (with  respect  to  clauses  (A),  (B) and (C) only) for the prior year
period  and the  comparable  figures in the  Budget.  For the  purposes  of this
Agreement, "Budget" shall mean the Company's annual operating and capital budget
with monthly  breakdowns  prepared by management  and signed by the President or
the Chief  Financial  Officer of the Company.  As soon as practicable and in any
case within  ninety (90)  calendar  days after the end of the fiscal year ending
December 31, 1998, the Company shall furnish Investor with a balance sheet as of
the end of such fiscal year, a statement of income and a statement of cash flows
of the Company for such year, setting forth in each case in comparative form the
figures from the Company's previous fiscal year, all prepared in accordance with
generally accepted  accounting  principles  consistently  applied and audited by
independent  auditors.  With the  annual  financial  statements  referred  to in
Section 3A.9(a),  there shall be delivered to Investor a certificate of the form
of certified  public  accountants  auditing  such  financial  statements  of the
Company,  in each case, to the effect that no knowledge has been obtained of any
violation  or default by the Company in the  performance  of its  agreements  or
covenants  contained herein, in the Certificate of Incorporation or in any other
material  agreement to which the Company is a party or of the  occurrence of any
condition, event or act which, with or without notice or lapse of time, or both,
would constitute a violation or an event of default, or, if such firm or officer
shall have obtained knowledge of any such violation, condition, event or act, it
or he (as  the  case  may  be)  shall  specify  in  such  certificate  all  such
violations,  conditions,  events and acts and the nature and status thereof. The
foregoing  financial  statements  shall be certified  by the  President or Chief
Financial  Officer  of the  Company to the effect  that such  statements  fairly
present the  financial  position  and  financial  results of the Company for the
fiscal period covered,  and shall be accompanied by a written explanation of (A)
any material  differences  between the operating  and financial  results and the
Budget,  (B) an  analysis  of any  significant  problems,  changes,  events  and
achievements,  including without limitation, those 


                                      -24-
<PAGE>


involving  sales and marketing  activities  and staffing and (C) a commentary on
developing  changes in the  business  outlook of the  Company,  together  with a
statement  as to their  anticipated  effect on future  operations  and  previous
forecasts.

               (b)  AUDITOR'S  LETTERS.  No later  than five (5)  business  days
following  receipt by the Company,  the Company shall furnish Investor with each
audit response letter,  accountant's  management letter and other written report
submitted to the Company by its  independent  public  accountants  in connection
with an annual or interim audit of the books of the Company.

               (c) NOTICE OF ACTIONS. No later than five (5) business days after
the commencement thereof, the Company shall furnish Investor with written notice
of all actions, suits, claims, proceedings,  investigations and that could have,
individually or in the aggregate, a Material Adverse Effect.

               (d) OTHER INFORMATION.  Promptly,  from time to time, the Company
shall  furnish  Investor  with such other  information  regarding  the business,
prospects, financial condition,  operations,  property or affairs of the Company
as Investor reasonably may request.

               (e)  Subsidiaries.  If for any period the Company  shall have any
subsidiary or  subsidiaries  whose accounts are  consolidated  with those of the
Company, then in respect of such period, the Company shall furnish Investor with
the  financial  statements,  letters,  notices and other  information  delivered
pursuant to the foregoing Sections 3A.9(a) through (d) shall be the consolidated
financial  statements of the Company and all such consolidated  subsidiaries and
the letters,  notices and other information relating to the Company and all such
subsidiaries, as well.

                                   ARTICLE IV

                              CONDITIONS TO CLOSING
                              ---------------------

4.1  CONDITIONS TO  INVESTOR'S  AND  PURCHASERS'  OBLIGATIONS  FOR CLOSING.  The
obligations  of Investor and each  Purchaser to effect the purchase of shares of
Series D Preferred  Stock  contemplated  by Section 1.1(a) of this Agreement are
subject to the  satisfaction  or written  waiver of the following  conditions in
Investor's and each Purchaser's reasonable discretion:

               (a) the  representations  and warranties of the Company contained
in this Agreement shall be true,  correct and complete in all material respects,
on and as of the Closing Date  (irrespective  of any notice  delivered after the
date hereof),  and the Company shall have performed in all material respects all
of its  obligations  under this Agreement  required to be performed prior to the
Closing Date;

               (b) there shall not have occurred any Material Adverse Effect;


                                      -25-
<PAGE>


               (c) there shall not have  occurred any event of default on any of
the Company's indebtedness (as defined in Section 2.16);

               (d) there shall not have  occurred  any  violation  of law by the
Company  which could  reasonably  be expected  to have,  individually  or in the
aggregate, a Material Adverse Effect;

               (e) Investor  shall have received a certificate of the President,
Chief Executive Officer or Chief Financial Officer of the Company,  on behalf of
the Company,  certifying as to the  fulfillment  of the  conditions set forth in
clauses (a) through (d) above;

               (f) no statute, rule, regulation,  judgment,  order or injunction
shall  be  enacted,  entered,   promulgated  or  enforced  (i)  challenging  the
transactions   contemplated   hereby,   seeking  to  restrain  or  prohibit  the
transactions  contemplated hereby or seeking any damages material in relation to
the Company or Investor,  (ii) seeking to impose  limitations  on the ability of
Investor to acquire or hold,  or exercise full rights of ownership of any shares
of Series D Preferred  Stock,  including  the right to vote such shares or (iii)
which  otherwise  could  reasonably be expected to have,  individually or in the
aggregate, a Material Adverse Effect;

               (g) Investor shall have been provided with evidence  satisfactory
to Investor in its reasonable  discretion that (i) the Board of Directors of the
Company  has  approved  the  transactions  contemplated  by this  Agreement  for
purposes  of Section  203 of the DGCL,  and (ii) the Board of  Directors  of the
Company  has taken all  necessary  action  to  guarantee  that none of the stock
purchase  rights  distributed  pursuant  to the  Shareholder  Protection  Rights
Agreement  are or  will  become  exercisable  as a  result  of the  transactions
contemplated  by this  Agreement  and  excluding  any  future  purchases  of the
Company's securities by Investor or any of the Purchasers.

               (h)  Investor   and  each   Purchaser   shall  have   received  a
certificate,  dated the Closing  Date,  duly  executed by the  Secretary  of the
Company  certifying as to (i) the attached copy of  resolutions  of the Board of
Directors of the Company  authorizing and approving the execution,  delivery and
performance  of  this  Agreement  and  the   consummation  of  the  transactions
contemplated  hereby and stating that such  resolutions  have not been modified,
amended, revoked or rescinded,  and (ii) the incumbency,  authority and specimen
signature of each officer of the Company  executing this Agreement and any other
document or instrument contemplated hereby;

               (i) Investor and each Purchaser shall have received a certificate
of the  Secretary  of  State  of the  State  of  Delaware  certifying  as to the
Company's  due  organization,  valid  existence  and good standing as a domestic
corporation in the State of Delaware as of a date not more than two (2) business
days prior to the Closing Date;

               (j)  Investor  shall have  received  an opinion of counsel to the
Company  (the  "Opinion  of the  Company's  Counsel")  and an  opinion of patent
counsel to the Company (the "Opinion of the  Company's  Patent  Counsel"),  each
dated the Closing Date,  in the form attached  hereto as Exhibit B-1 and Exhibit
B-2, respectively;


                                      -26-
<PAGE>


               (k) the Company shall have  received  (and  furnished to Investor
evidence thereof reasonably  satisfactory to Investor) any necessary or required
approvals or consents  from all  Governmental  Entities and other third  parties
(including the Company's  stockholders as contemplated in the Proxy Statement at
the  Company's  1999 Annual  Stockholders  Meeting (the  "Stockholder  Meeting")
necessary or required to complete the transactions contemplated hereby, and such
approvals  and  consents  shall not have been  withdrawn  or  expired  as of the
Closing Date and the Series D Certificate  of  Designation  shall have been duly
filed with the Secretary of State of the State of Delaware;

               (l) the Company shall have executed and delivered to Investor the
Stockholders and Registration Rights Agreement; and

               (m)  the  Company  shall  pay  Investor's  reasonable  costs  and
expenses in connection with the transactions contemplated hereby, including, but
not limited  to: (i)  Investor's  out-of-pocket  costs and  expenses  related to
Investor's  business due  diligence,  including  but not limited to the fees and
expenses of a consultant to evaluate the Company's  business and marketing plan,
up to a limit of $25,000;  (ii) the  reasonable  fees and expenses of Investor's
outside  counsel  incurred  in  connection  with the  transactions  contemplated
hereby,  including  Investor's due diligence;  and (iii) the reasonable  fees of
Investor's  patent counsel  incurred in connection with Investor's due diligence
investigation and related matters (the costs and expenses referred to in clauses
(i), (ii) and (iii) referred to collectively as the "Investor's Expenses").

          4.2  CONDITIONS  TO THE  COMPANY'S  OBLIGATIONS  FOR THE CLOSING.  The
obligations  of the  Company to effect the sale of shares of Series D  Preferred
Stock  contemplated  by  Section  1.1(a) of this  Agreement  are  subject to the
satisfaction    or    written    waiver    of    the    following    conditions:

               (a) the  representations  and  warranties  of  Investor  and each
Purchaser  contained in this Agreement shall be true and correct in all material
respects,  on and as of the Closing Date  (irrespective  of any notice delivered
after the date hereof),  and Investor and each Purchaser shall have performed in
all material  respects all of their respective  obligations under this Agreement
required to be performed prior to the Closing Date;

               (b)  the  Company  shall  have  received  certificates  from  the
authorized  officer of Investor,  and from each  Purchaser  certifying as to the
fulfillment of the condition set forth in clause (a) above; and

               (c) the Company  shall have  obtained all  requisite  stockholder
approval for the transactions  contemplated hereby at the Stockholder Meeting or
otherwise;  provided,  however,  that the Company  shall use its best efforts to
obtain  stockholder  approval  by a date no later than June 30,  1999.


                                      -27-
<PAGE>


                                    ARTICLE V

                                INDEMNIFICATION
                                ---------------

          5.1  INDEMNIFICATION  BY THE  COMPANY.  The Company  shall  indemnify,
defend  and  hold  harmless  Investor,   each  Purchaser  and  their  respective
affiliates and their respective  partners,  shareholders,  directors,  officers,
employees  and agents  from and against any loss,  liability,  claim,  damage or
expense (including court and arbitration fees and costs, and reasonable fees and
expenses  of  legal  counsel,  investigators,   expert  witnesses,  consultants,
accountants and other professionals) (a "Loss") suffered or incurred by any such
indemnified  party in  connection  with a third party claim arising from (i) any
untruth,  inaccuracy or breach of any  representation or warranty of the Company
contained in this Agreement, or (ii) any breach of any covenant or obligation of
the Company contained in this Agreement.

          5.2  INDEMNIFICATION  BY INVESTOR  AND  PURCHASERS.  Investor and each
Purchaser  shall,  severally  and not jointly,  indemnify  and hold harmless the
Company  and  its  affiliate  and  their  respective   partners,   shareholders,
directors,  officers,  employees and agents from an against any Loss suffered or
incurred by any such  indemnified  party in connection  with a third party claim
arising  from (i) any untruth,  inaccuracy  or breach of any  representation  or
warranty of Investor or  Purchasers  contained  in this  Agreement,  or (ii) any
breach of any covenant or obligation  of Investor or any Purchaser  contained in
this Agreement.

          5.3 PROCEDURE FOR INDEMNIFICATION.

               (a) In order for a party (the "indemnified party") to be entitled
to any indemnification  provided for under this Agreement in respect of, arising
out of or  involving  a  claim  or  demand,  made  by  any  person  against  the
indemnified  party (a "Third Party Claim"),  such indemnified  party must notify
the  indemnifying  party in writing of the Third Party Claim within  thirty (30)
calendar days after receipt by such  indemnified  party of written notice of the
Third Party Claim;  provided,  however,  that failure to give such  notification
shall not affect the indemnification provided hereunder except to the extent the
indemnifying  party  shall  have been  actually  prejudiced  as a result of such
failure (except that the indemnifying party shall not be liable for any expenses
incurred  during the period in which the  indemnified  party failed to give such
notice).  Thereafter,  the indemnified  party shall deliver to the  indemnifying
party,  within five (5)  business  days after the  indemnified  party's  receipt
thereof,  copies of all notices and documents  (including court papers) received
by the indemnified party relating to the Third Party Claim.

                    (i) If a Third  Party Claim is made  against an  indemnified
party,  the  indemnifying  party will be entitled to  participate in the defense
thereof  and,  if it so  chooses,  to assume the defense  thereof  with  counsel
selected by the  indemnifying  party;  provided,  such counsel is not reasonably
objected  to  by  the  indemnified  party;  and  provided,   further,  that  the
indemnifying  party first  notifies the  indemnified  party of its  intention to
assume such defense  within  thirty (30) calendar days of receipt of notice of a
Third Party Claim.  Should


                                      -28-
<PAGE>


the  indemnifying  party so elect to assume the defense of a Third Party  Claim,
the indemnifying party will not be liable to the indemnified party for any legal
expenses  subsequently  incurred by the indemnified party in connection with the
defense  thereof.  If the  indemnifying  party elects to assume the defense of a
Third Party Claim,  the  indemnified  party (x) will cooperate in all reasonable
respects with the indemnifying  party in connection with such defense,  (y) will
not admit any liability with respect to, or settle, compromise or discharge, any
Third Party Claim without the indemnifying party's prior written consent and (z)
will agree to any  settlement,  compromise  or  discharge of a Third Party Claim
which the indemnifying  party may recommend and which by its terms obligates the
indemnifying  party to pay the full amount of the liability in  connection  with
such Third Party Claim,  which  releases the  indemnified  party  completely  in
connection with such Third Party Claim,  which does not obligate the indemnified
party to take or  forbear  to take any  action,  and which  would not  adversely
affect the business, operations or properties of the Company.

                    (ii) In the event the  indemnifying  party shall  assume the
defense of any Third Party Claim as provided above, the indemnified  party shall
be  entitled to  participate  in (but not  control)  such  defense  with its own
counsel at its own  expense.  If the  indemnifying  party does not so assume the
defense of any such Third Party Claim, the indemnified party may defend the same
in such  manner  as it may  deem  appropriate  including,  but not  limited  to,
settling  such  claim  or  litigation   after  giving  notice  of  same  to  the
indemnifying  party on such terms as the indemnified party may deem appropriate,
and the  indemnifying  party promptly will reimburse the indemnified  party upon
written request.

                    (iii)  Anything  contained in this Agreement to the contrary
notwithstanding,  the  indemnifying  party  shall not be  entitled to assume the
defense of any Third  Party  Claim (and shall be liable for  counsel's  fees and
expenses  incurred by the indemnified party in defending such Third Party Claim)
if the Third Party Claim seeks an order, injunction or other equitable relief or
relief for other than  money  damages  against  the  indemnified  party that the
indemnified  party  reasonably  determines,  after  conferring  with its outside
counsel, cannot be separated from any related claim for money damages and which,
if successful, would adversely affect the business,  operations or properties of
the indemnified party; provided,  however, that if such equitable relief portion
of the Third Party Claim can be so separated  from that for money  damages,  the
indemnifying  party  shall be  entitled  to assume the  defense  of the  portion
relating to money damages.

          5.4 PERIOD OF INDEMNITY. The indemnities contained in this Article VII
shall  expire six (6) years from the Closing  Date,  except with  respect to the
untruth,  inaccuracy or breach of any  representation or warranty of the Company
contained in Sections 2.12 (Changes in Benefit Plans) and 2.14 (Taxes), in which
cases the  indemnification  period  shall be  extended  until the running of the
statute of  limitations  applicable to the taxable  period to which a particular
claim  relates;   or  Sections  2.3   (Organization  and   Qualification),   2.4
(Capitalization),   2.13  (ERISA   Compliance),   2.21  (Antitakeover   Statute;
Shareholder  Protection Rights Agreement),  2.22 (Protective  Agreements),  2.23
(Other Agreements Containing Non-Disclosure and Non-


                                      -29-
<PAGE>


Competition  Provisions) and 2.24 (Patents),  in which case the  indemnification
period shall not terminate at any time.

                                   ARTICLE VI

                                  MISCELLANEOUS
                                  -------------

          6.1 TERMINATION; EFFECT OF TERMINATION; EXPENSES.

               (a)  This  Agreement  may  be  terminated  and  the  transactions
contemplated  hereby may be abandoned at any time prior to the Closing Date: 

                    (i) by mutual written consent of the Company and Investor;

                    (ii) by Investor,  if the Closing does not occur by June 30,
1999; provided,  however, that the right to terminate this Agreement pursuant to
this Section 6.1(a) shall not be available to any party whose failure to fulfill
any of its obligations  under this Agreement  results in the failure of any such
condition; or

                    (iii) by either party if any court of competent jurisdiction
or any other  governmental body shall have issued an order,  decree or ruling or
taken  any  other  action  permanently   enjoining,   restraining  or  otherwise
prohibiting the transactions  contemplated hereby and such order, decree, ruling
or other action shall have become final and nonappealable.

               (b) In the event of termination and abandonment of this Agreement
pursuant to Section 6.1(a), this Agreement, except for the provisions of Section
3A.4 (only with respect to confidentiality), Section 6.1(c) and Article V, shall
forthwith  become void and have no effect,  without any liability on the part of
any party or its directors,  officers or  shareholders.  Nothing in this Section
6.1(b) shall relieve any party to this Agreement of liability for breach of this
Agreement.

               (c) In the event of  termination or abandonment of this Agreement
pursuant to Section  6.1(a)  above,  the Company's  liability to pay  Investor's
Expenses shall be limited to Seventy Five Thousand  Dollars  ($75,000.00) in the
aggregate.

          6.2 EXTENSION; WAIVER. The parties hereto, may (a) extend the time for
the  performance  of any of the  obligations  or other acts of the other parties
hereto,  (b)  waive  any  inaccuracies  in the  representations  and  warranties
contained herein by any other  applicable party or in any document,  certificate
or writing delivered  pursuant hereto by any other applicable party or (c) waive
compliance  with any of the  agreements  or  conditions  contained  herein.  Any
agreement  on the part of any party to any such  extension  or  waiver  shall be
valid only if set forth in an  instrument  in  writing  signed on behalf of such
party.


                                      -30-
<PAGE>


          6.3  ENTIRE  AGREEMENT;  ASSIGNMENT.  This  Agreement  (including  the
Schedules  and  Exhibits   hereto)  and  the  other  documents  and  instruments
contemplated  hereby, (a) constitute the entire agreement among the parties with
respect to the subject matter hereof,  and supersedes all other prior agreements
and understandings, both written and oral, among the parties or any of them with
respect to the subject matter hereof, and (b) shall not be assigned by operation
of law or  otherwise;  provided,  that Investor may assign any of its rights and
obligations  hereunder to any  affiliate of Investor  prior to Closing and after
Closing to any person,  but no such  assignment  shall  relieve  Investor of its
obligations hereunder unless such assignee or transferee agrees in writing to be
bound by the  terms  hereof  as  though an  original  signatory  hereto.  Either
Investor or any affiliate or associate of Investor may purchase shares of Series
D Preferred Stock under this Agreement.

          6.4  ENFORCEMENT OF THE AGREEMENT;  GOVERNING LAW;  JURISDICTION.  The
parties hereto agree that Investor would suffer  irreparable  damage would occur
in the event that any of the  provisions of this Agreement were not performed in
accordance with their specific terms or were otherwise  breached by the Company.
It is  accordingly  agreed that  Investor  shall be entitled to an injunction or
injunctions to prevent  breaches of this  Agreement and to enforce  specifically
the terms and  provisions  hereof in any state court located in the State of New
York, or the United States District Court for the Southern  District of New York
or any federal court in the State of New York (as to which the Company agrees to
submit to jurisdiction for the purposes of such or any other action), this being
in  addition  to any other  remedy to which  Investor  is  entitled at law or in
equity. This Agreement shall be governed by and construed in accordance with the
substantive  laws of the State of  Delaware  regardless  of the laws that  might
otherwise govern under principles of conflicts of laws applicable thereto.

          6.5 VALIDITY.  The invalidity or  unenforceability of any provision of
this  Agreement  shall not affect the  validity or  enforceability  of any other
provisions of this Agreement, which shall remain in full force and effect.

          6.6  NOTICES.  All  notices,   requests,  claims,  demands  and  other
communications  hereunder  shall be in writing  and shall be deemed to have been
duly given when delivered in person, by cable, telegram,  facsimile transmission
with  confirmation  of receipt,  or telex,  or by registered  or certified  mail
(postage  prepaid,  return  receipt  requested)  to the  respective  parties  as
follows:


                                      -31-
<PAGE>


                        if to Investor:

                        OCM Principal Opportunities Fund, L.P.
                        c/o Oaktree Capital Management, LLC
                        333 South Grand Avenue, 28th Floor
                        Los Angeles, CA 90071
                        Attention:  Stephen Kaplan, Principal
                                    Phone:  213-830-6350
                                    Michael P. Harmon, Vice President
                                    Phone:  213-830-6352
                                    Fax:    213-830-6395 

                        with a required copy to:

                        Dechert Price & Rhoads
                        4000 Bell Atlantic Tower
                        1717 Arch Street
                        Philadelphia, PA  19103
                        Attention:  Donna E. Ostroff, Esq.
                                    Phone:  215-994-4000
                                    Fax:    215-994-2222 

                        If to Purchasers:

                        See Exhibit E attached hereto

                        if to the Company:

                        CollaGenex Pharmaceuticals, Inc.
                        301 South State St.
                        Newtown, PA 18940 
                        Attention:  Nancy Broadbent,
                                    Vice President and Chief Financial Officer
                                    Phone:  215-579-7388
                                    Fax:    215-579-8577


                                      -32-
<PAGE>


                        with a required copy to:

                        Buchanan Ingersoll Professional Corporation
                        Princeton Forrestal Center
                        500 College Road East
                        Princeton, NJ 08540 
                        Attention:  David J. Sorin, Esq.
                                    Phone:  609-987-6800
                                    Fax:    609-520-0360

or to such  other  address  as the  person  to whom  notice  is  given  may have
previously  furnished  to the others in  writing  in the manner set forth  above
(provided  that  notice of any change of address  shall be  effective  only upon
receipt thereof).

          6.7 DESCRIPTIVE HEADINGS. The descriptive headings herein are inserted
for  convenience  of  reference  only and are not  intended  to be part of or to
affect the meaning or interpretation of this Agreement. 

          6.8 PARTIES IN  INTEREST.  This  Agreement  shall be binding  upon and
inure solely to the benefit of each party hereto, and nothing in this Agreement,
express or implied,  is  intended to confer upon any other  person any rights or
remedies  of any nature  whatsoever  under or by reason of this  Agreement.

          6.9  COUNTERPARTS.  This  Agreement  may be  executed  in two or  more
counterparts,  each of which shall be deemed to be an original, but all of which
shall constitute one and the same agreement.

          6.10  AMENDMENT.  This  Agreement  may  not be  amended  except  by an
instrument in writing signed on behalf of all the parties.

          6.11  SURVIVAL.   The  representations,   warranties,   covenants  and
agreements  of the  Company,  Investor  and  each  Purchaser  contained  in this
Agreement,  and all  statements  contained  in this  Agreement  or any  exhibit,
attachment or Schedule hereto or any certificate,  financial statement or report
or other document delivered pursuant to this Agreement or in connection with the
transactions contemplated hereby, shall be deemed incorporated in this Agreement
and shall constitute  representations,  warranties,  covenants and agreements of
the respective Party delivering the same. All such representations,  warranties,
covenants and  agreements  shall survive the Closing and (i) with respect to the
representations  and  warranties in Section 2.12.  and 2.14,  terminate when the
applicable  statute  of  limitations  with  respect  to the Tax  liabilities  in
question have expired;  (ii) with respect to the  representations and warranties
in Sections 2.3, 2.4, 2.13, 2.21, 2.22, 2.23 and 2.24 shall not terminate at any
time; and (iii) with respect to all other representations, warranties, covenants
and  agreements,  terminate  at  the  close  of  business  on the  fourth  (4th)
anniversary of the Closing Date. The Company acknowledges that


                                      -33-
<PAGE>


its  representations  and warranties in this Agreement  shall not be affected or
mitigated by any  investigation  conducted by Investor,  each Purchaser or their
representatives  prior  to the  Closing  or any  knowledge  of  Investor  or any
Purchaser.

          6.12  Certain  Definitions.   For  purposes  of  this  Agreement,  the
following terms shall have the meanings ascribed to them below:

               (a) "affiliate" of a person shall mean (i) a person that directly
or indirectly,  through one or more intermediaries,  controls, is controlled by,
or is  under  common  control  with,  the  first-mentioned  person  and  (ii) an
"associate",  as that  term is  defined  in Rule  12b-2  promulgated  under  the
Exchange Act as in effect on the date of execution of this Agreement.

               (b) "beneficial  owner" (including the term "beneficially own" or
correlative  terms) with respect to any securities  means a person that shall be
deemed to be the beneficial owner of such securities (i) that such person or any
of its affiliates  beneficially  owns,  directly or  indirectly,  (ii) that such
person or any of its affiliates  has,  directly or indirectly,  (A) the right to
acquire (whether such right is exercisable immediately or only after the passage
of time),  pursuant to any agreement,  arrangement or  understanding or upon the
exercise of  consideration  rights,  exchange  rights,  warrants or options,  or
otherwise,  or (B) the right to vote pursuant to any  agreement,  arrangement or
understanding or (iii) that are beneficially owned,  directly or indirectly,  by
any  other  person  with  which  such  person or any of its  affiliates  has any
agreement,  arrangement or understanding for the purpose of acquiring,  holding,
voting or disposing of any of such securities.

               (c) "control" (including the terms "controlling", "controlled by"
and "under common control with" or correlative terms) shall mean the possession,
direct  or  indirect,  of the power to  direct  or cause  the  direction  of the
management  and  policies  of a  person,  whether  through  ownership  of voting
securities, by contract, or otherwise.

               (d)  "Documents"  means  this  Agreement,  the  Stockholders  and
Registration Rights Agreement,  the Certificate of Designation,  the Convertible
Loan and Security  Agreement dated as of the date hereof between the Company and
Investor, and the Convertible Note.

               (e) "fully  diluted" in  reference  to the shares of Common Stock
means all outstanding  securities  entitled generally to vote in the election of
directors of the Company on a fully  diluted  basis,  after giving effect to the
exercise or  conversion of all options,  rights and  securities  exercisable  or
convertible into such voting securities.

               (f) "Material  Adverse  Effect" shall mean (i) any adverse change
in the condition (financial or otherwise), assets (including without limitation,
patents  and  licenses  to  patents),  liabilities,   business,  or  results  of
operations  or  prospects  of the  Company  and its  subsidiary,  which  change,
individually or in the aggregate,  is material to the Company or its subsidiary,
or (ii) any event, matter,  condition or effect which impairs the ability of the
Company or its  


                                      -34-
<PAGE>


subsidiary to perform on a timely basis its obligations  under this Agreement or
the consummation of the transactions contemplated by this Agreement. Materiality
under  clauses  (i) or (ii)  hereof  shall  be as  determined  in good  faith by
Investor.

               (g) "person" shall mean a natural person,  company,  corporation,
partnership, association, trust or any unincorporated organization.

               (h)  "Stockholders  and Registration  Rights Agreement" means the
Stockholders  and  Registration  Rights  Agreement  dated as of the date hereof,
among the Company, Investor and Purchasers.

               (i) "subsidiary" shall mean, when used with reference to a person
means a corporation the majority of the outstanding  voting  securities of which
are owned directly or indirectly by such person.


                                      -35-
<PAGE>


          IN WITNESS  WHEREOF,  each of the parties has caused this Agreement to
be executed on its behalf by its officers thereunto duly authorized,  on the day
and year first above written.

                             COLLAGENEX PHARMACEUTICALS, INC,



                             By: /s/ Brian M. Gallagher
                                ------------------------------------------
                             Name:  Brian M. Gallagher
                             Title: President and Chief Executive Officer


                             By: /s/ Nancy C. Broadbent
                                ------------------------------------------
                             Name:  Nancy C. Broadbent
                             Title: Vice President and Chief Financial Officer


                             OAKTREE PRINCIPAL OPPORTUNITIES FUND, L.P.

                             By:   Oaktree Capital Management, LLC, its 
                                   general partner


                             By: /s/ Stephen Kaplan
                                ------------------------------------------
                             Name:  Stephen Kaplan
                             Title: Principal


                             By: /s/ Michael Harmon
                                ------------------------------------------
                             Name:  Michael Harmon
                             Title: Vice President





                 [SIGNATURES CONTINUE ON THE FOLLOWING PAGE]



                                      -36-
<PAGE>


                             PURCHASERS:

                             /s/ Richard A. Horstmann
                             --------------------------------------------
                             Richard A. Horstmann


                             MARQUETTE VENTURE PARTNERS II, L.P.

                             By: /s/ James E. Daverman
                                ----------------------------------------
                             Name:  James E. Daverman
                             Title: 


                             MVP II AFFILIATES FUND, L.P.


                             By: /s/ James E. Daverman
                                -----------------------------------------
                             Name:  James E. Daverman
                             Title: 

                             /s/ Robert J. Easton
                             --------------------------------------------
                             Robert J. Easton


                             PEBBLEBROOK PARTNERS LTD


                             By: /s/ Stuart Schube
                                -----------------------------------------
                             Name:  Stuart Schube
                             Title: 





© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission