COLLAGENEX PHARMACEUTICALS INC
PREM14A, 1999-03-30
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                      Exchange Act of 1934 (Amendment No. )

Filed by the Registrant |X|
Filed by a Party other than the Registrant |_|

Check the appropriate box:

|X|  Preliminary Proxy Statement
                                        |_|  Confidential,  for  Use  of the
                                             Commission  Only (as  permitted  
                                             by  Rule 14a-6(e)(2))

|_|  Definitive Proxy Statement
|_|  Definitive Additional Material
|_|  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                        COLLAGENEX PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)
- --------------------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)

Payment of Filing Fee (Check the appropriate box):

|X|  No fee required.
|_|  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------
(2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
(3)  Per unit price or other underlying value of transaction  computed  pursuant
     to Exchange  Act Rule 0-11 (set forth the amount on which the filing fee is
     calculated and state how it was determined):

- --------------------------------------------------------------------------------
(4)  Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------
(5)  Total fee paid:

- --------------------------------------------------------------------------------
|_|  Fee paid previously with preliminary materials.

- --------------------------------------------------------------------------------
|_|  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the filing for which the  offsetting  fee was paid
     previously.  Identify the previous filing by registration statement number,
     or   the   form   or    schedule    and   the    date   of   its    filing.

(1)  Amount Previously Paid:

- --------------------------------------------------------------------------------
(2)  Form, Schedule or Registration Statement no.:

- --------------------------------------------------------------------------------
(3)  Filing Party:

- --------------------------------------------------------------------------------
(4)  Date Filed:

- --------------------------------------------------------------------------------

<PAGE>

                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 SOUTH STATE STREET
                                NEWTOWN, PA 18940



                                                    April 12, 1999

To Our Stockholders:

         You are  cordially  invited  to  attend  the  1999  Annual  Meeting  of
Stockholders of CollaGenex  Pharmaceuticals,  Inc. at 8:30 A.M.,  local time, on
Tuesday, May 11, 1999, at the Marriott Hotel, 1201 Market Street,  Philadelphia,
Pennsylvania.

         The  Notice of  Meeting  and Proxy  Statement  on the  following  pages
describe the matters to be presented at the meeting.

         It is  important  that your shares be  represented  at this  meeting to
assure the presence of a quorum.  Whether or not you plan to attend the meeting,
we hope  that you will  have your  stock  represented  by  signing,  dating  and
returning your proxy in the enclosed envelope,  as soon as possible.  Your stock
will be voted in accordance with the instructions you have given in your proxy.

         Thank you for your continued support.


                                   Sincerely,



                                  Brian M. Gallagher, Ph.D.
                                  President and
                                  Chief Executive Officer

<PAGE>
                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 SOUTH STATE STREET
                                NEWTOWN, PA 18940



                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 11, 1999



     The  Annual  Meeting  of   Stockholders   (the   "Meeting")  of  COLLAGENEX
PHARMACEUTICALS,  INC., a Delaware corporation (the "Company"),  will be held at
the Mariott Hotel, 1201 Market Street, Philadelphia,  Pennsylvania,  on Tuesday,
May 11, 1999, at 8:30 A.M., local time, for the following purposes:

(1)  To  elect  eight  directors  to serve  until  the next  Annual  Meeting  of
     Stockholders  and until their  respective  successors  shall have been duly
     elected and qualified;

(2)  To amend the  Company's  1996 Stock  Option  Plan (the "1996  Stock  Option
     Plan") to increase the maximum  aggregate  number of shares of Common Stock
     available for issuance  thereunder from 750,000 to 1,500,000  shares and to
     reserve an  additional  750,000  shares of Common  Stock of the Company for
     issuance in  connection  with awards  granted  under the 1996 Stock  Option
     Plan;

(3)  To approve the  consummation of a private  placement  pursuant to which the
     Company  shall issue  shares of Series D Cumulative  Convertible  Preferred
     Stock,  $.01 par value,  representing  21.2% of the issued and  outstanding
     equity securities of the Company;

(4)  To ratify the appointment of KPMG LLP as independent  auditors for the year
     ending December 31, 1999; and

(5)  To transact such other  business as may properly come before the Meeting or
     any adjournment or adjournments thereof.

     Holders  of Common  Stock of record at the close of  business  on March 26,
1999 are entitled to notice of and to vote at the Meeting, or any adjournment or
adjournments  thereof.  A complete list of such stockholders will be open to the
examination of any stockholder at the Company's  principal  executive offices at
301 South State Street,  Newtown,  Pennsylvania  18940 and at the Mariott Hotel,
1201 Market Street, Philadelphia, Pennsylvania, for a period of 10 days prior to
the Meeting. The Meeting may be adjourned from time to time without notice other
than by announcement at the Meeting.

<PAGE>


     IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED REGARDLESS OF THE NUMBER OF
SHARES YOU MAY HOLD.  WHETHER  OR NOT YOU PLAN TO ATTEND THE  MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE THE COMPANY THE EXPENSE OF FURTHER SOLICITATION. EACH PROXY GRANTED MAY
BE REVOKED BY THE  STOCKHOLDER  APPOINTING  SUCH PROXY AT ANY TIME  BEFORE IT IS
VOTED.  IF YOU  RECEIVE  MORE  THAN ONE  PROXY  CARD  BECAUSE  YOUR  SHARES  ARE
REGISTERED  IN  DIFFERENT  NAMES OR  ADDRESSES,  EACH SUCH PROXY CARD  SHOULD BE
SIGNED AND RETURNED TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.

                                          By Order of the Board of Directors


                                          Nancy C. Broadbent
                                            Secretary
Newtown, Pennsylvania
April 12, 1999

        THE COMPANY'S 1998 ANNUAL REPORT ACCOMPANIES THE PROXY STATEMENT.


                                       2
<PAGE>

                        COLLAGENEX PHARMACEUTICALS, INC.
                             301 SOUTH STATE STREET
                                NEWTOWN, PA 18940

                 -------------------------------------------------
                                PROXY STATEMENT
                 -------------------------------------------------

     This Proxy  Statement is furnished in connection  with the  solicitation by
the Board of Directors of CollaGenex  Pharmaceuticals,  Inc. (the  "Company") of
proxies to be voted at the Annual Meeting of  Stockholders  of the Company to be
held on Tuesday, May 11, 1999 (the "Meeting") at the Marriott Hotel, 1201 Market
Street,  Philadelphia,  Pennsylvania  at  8:30  A.M.,  local  time,  and  at any
adjournment or adjournments thereof. Holders of record of Common Stock, $.01 par
value ("Common  Stock"),  as of the close of business on March 26, 1999, will be
entitled  to  notice  of and to  vote at the  Meeting  and  any  adjournment  or
adjournments  thereof.  As of that date,  there were 8,589,704  shares of Common
Stock issued and outstanding and entitled to vote. Each share of Common Stock is
entitled to one vote on any matter presented at the Meeting. The number of votes
entitled to be cast at the Meeting is 8,589,704.

     If proxies in the accompanying form are properly executed and returned, the
Common Stock represented  thereby will be voted in the manner specified therein.
If not otherwise specified,  the Common Stock represented by the proxies will be
voted (i) FOR the election of the eight nominees named below as directors,  (ii)
FOR a proposal to amend the  Company's  1996 Stock  Option Plan (the "1996 Stock
Option Plan") to increase the maximum number of shares of Common Stock available
for issuance  under the 1996 Stock Option Plan from 750,000 to 1,500,000  shares
and to reserve an additional  750,000  shares of Common Stock of the Company for
issuance in  connection  with awards  granted  under the 1996 Stock Option Plan,
(iii) FOR a proposal to  consummate  a private  placement  pursuant to which the
Company shall issue shares of Series D Cumulative  Convertible  Preferred Stock,
$.01 par value ("Series D Preferred  Stock"),  representing  21.2% of the issued
and outstanding  equity securities of the Company;  (iv) FOR the ratification of
the appointment of KPMG LLP as independent auditors for the year ending December
31, 1999, and (v) in the discretion of the persons named in the enclosed form of
proxy,  on any other proposals which may properly come before the Meeting or any
adjournment or adjournments  thereof.  Any Stockholder who has submitted a proxy
may revoke it at any time before it is voted, by written notice addressed to and
received by the Secretary of the Company,  by  submitting a duly executed  proxy
bearing a later date or by electing to vote in person at the  Meeting.  The mere
presence  at the  Meeting of the person  appointing  a proxy does not,  however,
revoke the appointment.

     The  presence,  in person or by proxy,  of holders of Common Stock having a
majority  of the votes  entitled to be cast at the Meeting  shall  constitute  a
quorum.  The  affirmative  vote by the holders of a  plurality  of the shares of
Common  Stock  represented  at the  Meeting  is  required  for the  election  of
directors,  provided  a quorum is  present  in person or by proxy.  All  actions
proposed  herein  other than the  election  of  directors  may be taken upon the
affirmative  vote of  Stockholders  possessing  a majority  of the voting  power
represented at the Meeting,  provided a quorum is present in person or by proxy.
Certain Stockholders of the Company, owning in the aggregate 4,764,580 shares of
Common Stock (approximately 55.2% of the currently  outstanding shares of Common
Stock  entitled  to vote at the  Meeting)  have  agreed  to vote in favor of the
private placement set forth in proposal (iii) above.

     Abstentions  are included in the shares present at the Meeting for purposes
of  determining  whether a quorum is present,  and are counted as a vote against
for purposes of  determining  whether a proposal is approved.  Broker  non-votes
(when shares are represented at the Meeting by a proxy  specifically  conferring
only limited  authority  to vote on certain  matters and no authority to vote on
other  matters)  are  included  in the  determination  of the  number  of shares
represented  at the Meeting  for  purposes  of  determining  whether a quorum is
present but are not counted for purposes of  determining  whether a proposal has
been approved and thus have no effect on the outcome.

     This Proxy Statement, together with the related proxy card, is being mailed
to the Stockholders of the Company on or about April 12, 1999. The Annual Report
to Stockholders  of the Company for the year ended December 31, 1998,  including
financial  statements (the "Annual Report"),  is being mailed together with this
Proxy

<PAGE>

Statement to all  Stockholders of record as of March 26, 1999. In addition,  the
Company  has  provided  brokers,  dealers,  banks,  voting  trustees  and  their
nominees,  at the Company's expense, with additional copies of the Annual Report
so that such record holders could supply such materials to beneficial  owners as
of March 26, 1999.

                              ELECTION OF DIRECTORS

     At the  Meeting,  eight  directors  are to be elected  (which  number shall
constitute  the entire  Board of  Directors of the Company) to hold office until
the next Annual Meeting of Stockholders  and until their  successors  shall have
been elected and qualified.

     It is the  intention of the persons  named in the enclosed form of proxy to
vote the stock represented thereby, unless otherwise specified in the proxy, for
the  election as  directors of the persons  whose names and  biographies  appear
below.  All of the  persons  whose  names and  biographies  appear  below are at
present directors of the Company. In the event any of the nominees should become
unavailable or unable to serve as a director,  it is intended that votes will be
cast for a substitute nominee designated by the Board of Directors. The Board of
Directors  has no reason to believe  that the  nominees  named will be unable to
serve if elected.  Each of the  nominees  has  consented  to being named in this
Proxy Statement and to serve if elected.

     The current  Board of Directors  and nominees for election to the Board are
as follows:
<TABLE>
<CAPTION>

                                                         Served as a         Positions with
Name                                        Age         Director Since       the Company
- ----                                        ---         --------------       -----------

<S>                                         <C>              <C>                                  
Helmer P.K. Agersborg, Ph.D..........       70               1992            Chairman of the Board
Brian M. Gallagher, Ph.D.............       51               1994            President, Chief Executive Officer
                                                                             and Director
Peter R. Barnett, D.M.D..............       47               1997            Director
James E. Daverman....................       49               1995            Director
Robert J. Easton.....................       54               1993            Director
Stephen W. Ritterbush, Ph.D..........       52               1992            Director
Pieter J. Schiller...................       61               1995            Director
Terence E. Winters, Ph.D.............       56               1992            Director
</TABLE>

     The principal  occupations and business  experience,  for at least the past
five years, of each nominee are as follows:

     Dr.  Agersborg has been Chairman of the Company's  Board of Directors since
March 1992 and served as its Chief  Executive  Officer and President until March
1994.  Dr.  Agersborg  also serves as Chairman,  President and Chief  Scientific
Officer of Afferon Corporation and Vice-Chairman and Chief Scientific Officer of
Maret Corporation,  having joined such companies in September 1992 and September
1994,  respectively.  Dr.  Agersborg  has  also  served  as  director  of  Lidak
Pharmaceutical   since  October  1992.   Each  of  such  companies   engages  in
pharmaceutical development. From May 1987 until his retirement in June 1990, Dr.
Agersborg was the President of Wyeth-Ayerst  Research  Division of American Home
Products  Corporation.  Prior  to that,  and  beginning  in 1975,  he was a Vice
President,  and then an Executive Vice President,  of Wyeth-Ayerst  Laboratories
Research Division.

     Dr.  Gallagher  joined the  Company in April  1994 as  President  and Chief
Executive  Officer and was elected to the Board of Directors  in November  1994.
From 1988 until joining the Company, Dr. Gallagher was

                                      -2-
<PAGE>

employed by  Bristol-Myers  Squibb Company ("BMS") and its  predecessor,  Squibb
Corporation,  in  various  executive  positions  including  strategic  planning,
worldwide  product  and  business  development  and  marketing.  From 1991 until
joining the Company,  Dr.  Gallagher was Vice  President and General  Manager of
Squibb Diagnostics,  the in vivo imaging pharmaceutical division. Prior to that,
Dr.  Gallagher  served  for ten  years  with E.I.  DuPont de  Nemours & Co. in a
variety  of  pharmaceutical  research,   development,   marketing  and  business
management positions.

     Dr.  Barnett has been a director of the Company since  February 1997. He is
Senior Vice President and Chief Operating Officer of United Dental Care, Inc., a
managed dental benefits firm, where he has served in such capacity since January
1995.  From August 1994 to January 1995, Dr.  Barnett was Executive  Director of
Prudential  DMO, and from March 1993 to August 1994, he served as an independent
consultant  in the managed  care field.  From  January  1985 to March 1993,  Dr.
Barnett was a Senior Vice President with Pearle Vision, Inc.

     Mr.  Daverman has been a director of the Company since November 1995. He is
a managing  general partner of Marquette  Venture  Partners  ("MVP"),  a venture
capital  investment  company which he founded in 1987. Mr. Daverman is President
of Marquette Management Partners,  LLC, the general partner of Marquette Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners II, L.P. and MVP II Affiliates  Fund,  L.P. He is a
member  of the  Board  of  Directors  of the  Technology  Advisory  Group of the
Technology  Management  Office of the University of Michigan.  Mr. Daverman is a
member of the Board of Directors  of  Endocardial  Solutions,  Inc. and numerous
privately held companies.

     Mr.  Easton has been a director of the Company since  November  1993. He is
Managing  Director of The Wilkerson Group,  Inc., a major health care consulting
firm,  where he has served in such capacity  since 1986.  Mr. Easton is a former
President of the Biomedical Marketing Association.

     Dr.  Ritterbush  has been a director of the Company  since its  founding in
January 1992. He is managing  general  partner of Fairfax  Partners/The  Venture
Fund of Washington,  L.P., a venture capital fund,  which he co-founded in 1989.
Dr. Ritterbush serves as a director and is on the compensation  committee of the
Board of Directors of Apache Medical Systems, Inc.

     Mr.  Schiller has been a director of the Company since  September  1995. He
joined  Advanced  Technology  Ventures  ("ATV"),  a  venture  capital  fund,  in
September 1986 and is currently a general  partner of various ATV funds. He is a
director of Anthra  Pharmaceuticals,  Inc., Endius,  Inc., Afferon  Corporation,
Avicenna  Systems  Corporation,   HealthShare   Technology,   Inc.  and  Novoste
Corporation.

     Dr.  Winters  has been a director  of the  Company  since its  founding  in
January  1992. He is a general  partner of Columbine  Venture  Funds,  a venture
capital fund, of which he was a founder in 1983. He also serves as a director of
Afferon Corporation, Maret Corporation and Melanotan Corporation.

     All directors hold office until the next annual meeting of stockholders and
until their successors  shall have been duly elected and qualified.  None of the
Company's  directors  are  related  to any other  director  or to any  executive
officer of the Company.

     THE BOARD OF DIRECTORS  RECOMMENDS THAT  STOCKHOLDERS  VOTE FOR EACH OF THE
NOMINEES FOR THE BOARD OF DIRECTORS.

COMMITTEES AND MEETINGS OF THE BOARD

     The Board of Directors  has a  Compensation  Committee  (the  "Compensation
Committee"),  which approves  salaries and incentive  compensation for executive
officers of the Company and which  administers the Company's stock option plans,
and an Audit  Committee,  which  reviews  the results and scope of the audit and
other  services  provided  by  the  Company's   independent   accountants.   The
Compensation  Committee  currently  consists  of Robert J.  Easton,  Stephen  W.
Ritterbush,  Ph.D. and Terence E. Winters,  Ph.D. The Compensation Committee was
established  in March 1996 and held two  meetings in 1998.  The Audit  Committee
currently consists of James E. Daverman, Stephen W. Ritterbush, Ph.D. and Pieter
J.  Schiller.  The Audit  Committee was  established  in March 1996 and held one
meeting in 1998. There were four meetings of the Board of Directors during 1998.
Each

                                      -3-
<PAGE>

incumbent director attended at least 75% of the aggregate of all meetings of the
Board of  Directors  held during the period in which he served as a director and
the total number of meetings held by the committee on which he served during the
period, if applicable.

COMPENSATION OF DIRECTORS

     Helmer P.K. Agersborg is paid $36,000 per year for his services as Chairman
of the Board.  Peter R. Barnett  receives $1,500 per meeting for each meeting of
the Board of Directors  attended.  The Wilkerson Group, Inc. receives $1,500 per
meeting for each meeting of the Board of Directors  attended by Mr.  Easton.  No
other  directors  receive  cash  compensation  for  services  on  the  Board  of
Directors.  The Company  provides  reimbursement to directors for reasonable and
necessary  expenses  incurred in connection  with  attendance at meetings of the
Board of Directors and other Company business.

     From  time-to-time,  members of the Board of  Directors  have been  granted
options  to  purchase  shares  of Common  Stock of the  Company.  See  "Security
Ownership of Certain Beneficial Owners and Management."

     Pursuant to the Company's 1996 Non-Employee Director Stock Option Plan (the
"Non-Employee   Plan"),  each  new  non-employee  director  of  the  Company  is
automatically granted an option to purchase 25,000 shares of Common Stock, at an
exercise  price per share equal to the then current fair market value per share.
All such options become exercisable in five equal annual installments commencing
one year  after the date of grant  provided  that the  optionee  then  remains a
director  at the time of  vesting  of the  installments.  The right to  exercise
annual  installments  of  options  under the  Non-Employee  Plan will be reduced
proportionately based on the optionee's actual attendance at Directors' meetings
if the optionee fails to attend at least 75% of the Directors'  meetings held in
any calendar year. On February 12, 1998 Dr. Gallagher was granted 75,000 options
under the 1996 Stock Option Plan at an exercise  price of $6.25 per share and on
January 15, 1999 Dr.  Gallagher was granted 75,000 options  outside of any stock
option plan at an  exercise  price of $10.0625  per share.  All of such  options
become  exercisable  in  five  equal  annual   installments   beginning  on  the
anniversary of their respective grant dates.


                                      -4-
<PAGE>

                               EXECUTIVE OFFICERS

     The  following  table  identifies  the  current  executive  officers of the
Company:
<TABLE>
<CAPTION>

                                                       Capacities in                       In Current
Name                                           Age     Which Served                        Position Since
- ----                                           ---     ------------                        --------------

<S>                                             <C>                                              <C> 
Brian M. Gallagher, Ph.D...............         51     President, Chief Executive          April 1994
                                                       Officer and Director                (Director since November
                                                                                           1994)
Robert A. Ashley(1)....................         41     Senior Vice President               January 1999
Nancy C. Broadbent(2)..................         43     Chief Financial Officer,            March 1996
                                                       Treasurer and Secretary
Douglas C. Gehrig(3)...................         54     Vice President, Sales               June 1997
David P. Pfeiffer(4)...................         36     Vice President, Marketing           June 1997
- -----------
</TABLE>

(1)  Mr.  Ashley  joined  the  Company  in  September  1994 as  Vice  President,
     Commercial Development. He was promoted to Senior Vice President in January
     1999.  From 1989 until joining the Company,  he was employed by BMS and its
     predecessor,  Squibb  Corporation,  in various positions  including product
     development,  commercial and business  development  and, most recently,  as
     Director,  Business  Development where he was responsible for the worldwide
     product and market development of several new drugs. From 1979 to 1989, Mr.
     Ashley  held  various  positions  at  Amersham   International  (UK)  Ltd.,
     including  research,  development,   manufacturing,   sales  and  marketing
     positions,  as well as worldwide  product  development  and product  launch
     positions.

(2)  Ms. Broadbent joined the Company in March 1996 as Chief Financial  Officer,
     Treasurer and Secretary.  From October 1994 until joining the Company,  Ms.
     Broadbent  served as Senior Vice  President,  Chief  Financial  Officer and
     director of Human Genome  Sciences,  Inc., a  biotechnology  company.  From
     January  1993 to  October  1994,  she  served as Vice  President  and Chief
     Financial  Officer of Cangene,  Inc.,  a  biopharmaceutical  company.  From
     January 1992 through  December 1992, Ms. Broadbent served as an independent
     financial consultant. From March 1990 to December 1991, she was employed by
     Baring Brothers & Co., Inc., initially as Senior Vice President and then as
     Executive Director,  Corporate Finance. Prior to that, Ms. Broadbent served
     for nine years in corporate finance  positions with Salomon Brothers,  Inc.
     and PaineWebber Incorporated.

(3)  Mr. Gehrig joined the Company in June 1997 as Vice President,  Sales.  From
     September  1991  until  joining  the  Company,   he  was  employed  by  the
     Musculoskeletal  Transplant  Foundation,  most recently as Vice  President,
     Hospital  Sales.  From January 1990 until  September  1991,  Mr. Gehrig was
     Director of Sales for the  Consumer  Product  Division  of Warner  Lambert.
     Prior to that, he served for 19 years in various sales, marketing and sales
     management positions with Johnson & Johnson.

(4)  Mr. Pfeiffer joined the Company in June 1997 as Vice President,  Marketing.
     From  September 1995 until June 1997,  Mr.  Pfeiffer  served as Director of
     Marketing,  Health Management  Services,  for SmithKline Beecham.  From May
     1994 to September 1995, Mr. Pfeiffer served as Director, Disease Management
     Services  of Stuart  Disease  Management  Services,  a  division  of Zeneca
     Pharmaceuticals.  From  October 1991 to May 1994 he was employed in various
     product management positions with Zeneca  Pharmaceuticals  Group. From July
     1988 to October  1991,  Mr.  Pfeiffer  held various  marketing  and product
     management  positions  with the Lederle  Laboratories  Division of American
     Cyanamid.

                                      -5-
<PAGE>

     None of the Company's  executive officers is related to any other executive
officer or to any director of the Company. Executive officers of the Company are
elected  annually by the Board of Directors and serve until their successors are
duly elected and qualified.

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

     Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended  (the
"Exchange Act"), requires the Company's directors, officers and stockholders who
beneficially own more than 10% of any class of equity  securities of the Company
registered pursuant to Section 12 of the Exchange Act to file initial reports of
ownership  and reports of changes in  ownership  with  respect to the  Company's
equity securities with the Securities and Exchange  Commission (the "SEC").  All
reporting  persons are  required by SEC  regulation  to furnish the Company with
copies of all reports that such reporting  persons file with the SEC pursuant to
Section 16(a).

     Based solely on the Company's  review of the copies of such forms  received
by the Company  and upon  written  representations  of the  Company's  reporting
persons  received by the Company,  each such  reporting  person has filed all of
their respective reports pursuant to Section 16(a) on a timely basis.


                                      -6-
<PAGE>

                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal 1998, 1997 and 1996

     The following Summary Compensation Table sets forth information  concerning
compensation  for services in all  capacities  awarded to,  earned by or paid to
each  person who served as the  Company's  Chief  Executive  Officer at any time
during 1998 and each other executive officer of the Company whose aggregate cash
compensation  exceeded  $100,000  at the end of 1998  (collectively,  the "Named
Executives") during the years ended December 31, 1998, 1997 and 1996.

                          SUMMARY COMPENSATION TABLE(1)
<TABLE>
<CAPTION>

- -----------------------------------------------------------------------------------------------------------------------------
                                                                                         Long-Term Compensation
                                                            Annual Compensation                 Awards

                                                 --------------------------------------------------------------
                                                                                              Securities         
                                                       Salary                Bonus            Underlying          All Other
    Name and Principal Position         Year                                                    Options         Compensation
                                                        ($)                   ($)                  (#)               ($)
                (a)                     (b)             (c)                   (d)                  (g)               (i)
- ------------------------------------ ----------- ------------------- ---------------------- ---------------------------------

<S>                                   <C>            <C>                    <C>                <C>            <C>
Brian M. Gallagher, Ph.D.(2)....        1998           262,500                 53,074            75,000            --
     President and                      1997           250,000                 42,536            50,000            --
     Chief Executive Officer            1996           225,000                 50,000                --            --

Robert A. Ashley................        1998           175,000                 36,701            25,000            --
     Senior Vice President              1997           157,500                 36,125            25,000            --
                                        1996           139,961                 30,000                --            --

Nancy C. Broadbent(3)...........        1998           182,000                 36,789            25,000            --
     Chief Financial Officer,           1997           173,250                 36,380            25,000            --
     Treasurer and Secretary            1996           137,500                 30,000            60,000            --

Douglas C. Gehrig(4)............        1998           153,500                 36,413            20,000            --
     Vice President, Sales              1997            78,977                    800            60,000            --

David F. Pfeiffer(5)............        1998           153,500                 36,544            20,000        35,000(6)
     Vice President, Marketing          1997            84,375                    656            60,000            --
- -----------
</TABLE>

(1)  The costs of certain benefits are not included because they did not exceed,
     in the case of each  Named  Executive,  the lesser of $50,000 or 10% of the
     total annual salary and bonus reported in the above table.

(2)  In November 1994, Dr. Gallagher  purchased  125,000 shares of the Company's
     restricted Common Stock at $0.335 per share. Such shares are subject to the
     Company's  right of first  refusal,  pursuant  to which the Company may buy
     them back from Dr.  Gallagher  at $0.335 per  share,  if Dr.  Gallagher  is
     terminated for cause, and at the then current market value per share, if he
     is terminated  for any other reason.  At December 31, 1998,  Dr.  Gallagher
     held 125,000  shares of  restricted  Common Stock with a year-end  value of
     $1,161,250  based on the value of the Common  Stock as of such date ($9.625
     per share),  less the purchase price per share paid for such shares ($0.335
     per share).

(3)  Ms. Broadbent joined the Company in March 1996 as Chief Financial  Officer,
     Treasurer and Secretary.

(4)  Mr. Gehrig joined the Company in June 1997 as Vice President, Sales.

(5)  Mr. Pfeiffer joined the Company in June 1997 as Vice President, Marketing.

(6)  Represents reimbursable relocation allowance.



                                      -7-
<PAGE>

Option Grants in 1998

     The following table sets forth information  concerning individual grants of
stock options made pursuant to the 1996 Stock Option Plan during 1998 to each of
the Named Executives.
<TABLE>
<CAPTION>

                        OPTION GRANTS IN LAST FISCAL YEAR

- ------------------------------------------------------------------------------------------- ---------------------------
                                       Individual Grants

                                                                                            ---------------------------
- -------------------------------- --------------- ------------- ------------- -------------- ---------------------------
                                                                                               Potential Realizable
                                                  Percent of                                         Value at
                                   Number of        Total                                    Assumed Annual Rates of
                                   Securities      Options                                            Stock
                                   Underlying     Granted to   Exercise or                    Price Appreciation for
                                    Options       Employees     Base Price                            Option
                                    Granted       in Fiscal                   Expiration             Term (3)
                                                                                            ---------------------------
             Name                    (#)(1)        Year (2)       ($/Sh)         Date           5%($)         10%($)
              (a)                     (b)            (c)           (d)            (e)            (f)           (g)
- -------------------------------- --------------- ------------- ------------- -------------- --------------- -----------

<S>                                  <C>              <C>         <C>           <C>            <C>          <C>
Brian M. Gallagher, Ph.D.....        75,000           23.9%       $6.25         2/12/08        294,794       747,067

Robert A. Ashley.............        25,000            8.0%       $6.25         2/12/08         98,265       249,022

Nancy C. Broadbent...........        25,000            8.0%       $6.25         2/12/08         98,265       249,022

Douglas C. Gehrig............        20,000            6.4%       $6.25         2/12/08         78,612       199,218

David F. Pfeiffer............        20,000            6.4%       $6.25         2/12/08         78,612       199,218
- -----------
</TABLE>

(1)  Such options were granted  pursuant to and in accordance with the Company's
     1996 Stock Option Plan. For a complete  description of such plan, see "1996
     Stock Option Plan Proposal."

(2)  Based on an  aggregate  of 313,500  options  granted to  employees in 1998,
     including options granted to Named Executives.

(3)  Based on a grant date fair market value of $6.25 per share.



                                      -8-
<PAGE>

Aggregated Option Exercises in 1998
and Year End Option Values

     The  following  table sets forth  information  concerning  each exercise of
options  during 1998 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.
<TABLE>
<CAPTION>

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR END OPTION VALUES

- -------------------------------------------------------------------------------------------------------------------------
                                                                                Number of
                                                                          Securities Underlying            Value of
                                                                               Unexercised               Unexercised
                                                                                Options at               In-the-Money
                                                                                  Fiscal                  Options at
                                                                                 Year-End                   Fiscal
                                         Shares                                    (#)                     Year-End
                                       Acquired on           Value             Exercisable/                ($) (1)
                                        Exercise           Realized           Unexercisable              Exercisable/
               Name                        (#)                ($)                  (d)                  Unexercisable
               (a)                         (b)                (c)                                            (e)
- --------------------------------    ------------------ ------------------ -------------------      ----------------------
<S>                                         <C>            <C>               <C>                      <C>     
Brian M. Gallagher, Ph.D........                --              --            97,500/127,500          $786,688/$383,438
Robert A. Ashley................             9,375         $82,406            42,500/54,375           $327,172/$175,859
Nancy C. Broadbent..............                --              --            17,000/69,000            $94,625/$279,875
Douglas L. Gehrig...............                --              --            24,000/56,000               $0/$67,500
David P. Pfeiffer...............                --              --            24,000/56,000               $0/$67,500
- -----------
</TABLE>

(1)  Based on a year end fair market value of the underlying securities equal to
     $9.625 per share, less the exercise price payable for such shares.

EMPLOYMENT   CONTRACTS,   TERMINATION   OF  EMPLOYMENT   AND   CHANGE-IN-CONTROL
ARRANGEMENTS

     The  Company  has  executed  indemnification  agreements  with  each of its
executive  officers  and  directors  pursuant to which the Company has agreed to
indemnify such parties to the full extent  permitted by law,  subject to certain
exceptions,  if such party becomes  subject to an action because such party is a
director,  officer, employee, agent or fiduciary of the Company. In general, the
Company's employees are covered by confidentiality agreements.

     In addition,  each of Dr.  Gallagher,  Ms.  Broadbent  and Messrs.  Ashley,
Gehrig and  Pfeiffer  have agreed that during the term of his or her  employment
and for a period of two years  thereafter,  such  person  will not  directly  or
indirectly provide services to or for any business engaged in research regarding
the  development,   manufacture,  testing,  marketing  or  sale  of  collagenase
inhibiting drugs for application in periodontal disease or any other application
which, during the period of such person's employment with the Company, is either
marketed or in advanced clinical development by the Company.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     The  Compensation  Committee  consists  of, and during 1998  consisted  of,
Robert J. Easton,  Stephen W.  Ritterbush,  Ph.D. and Terence E. Winters,  Ph.D.
There are no, and during 1998 there were no, Compensation Committee Interlocks.

                                      -9-
<PAGE>

     As of  April  1,  1999,  each  of  Fairfax  Partners/The  Venture  Fund  of
Washington,  L.P., with which Dr. Ritterbush is affiliated and Columbine Venture
Fund II, L.P.,  with which Dr. Winters is  affiliated,  held 446,517 and 969,328
shares, respectively, of the Company's Common Stock which were previously issued
upon conversion of certain shares of the Company's  Series A, Series B or Series
C Redeemable  Preferred Stock  previously held by such entities.  Such shares of
Common Stock are entitled to certain  registration  rights and certain rights to
participate in certain future offerings undertaken by the Company.

     In September 1995, the Company and the then holders of the Company's Series
A, Series B and Series C Redeemable  Preferred Stock entered into a Registration
Rights  Agreement  (the  "Rights  Agreement")  pursuant to which the Company has
granted certain registration rights to such Stockholders. Pursuant to the Rights
Agreement,  at any time  beginning six months after June 20, 1996, the effective
date of the  Company's  initial  public  offering,  the  holders  of at  least a
majority of the Common Stock issued upon the  conversion of the Series A, Series
B and Series C Redeemable  Preferred Stock (the  "Registrable  Securities") have
the right, subject to certain restrictions set forth in the Rights Agreement, to
require that the Company register the Registrable  Securities  requested by such
holders at the  Company's  expense (on no more than two  occasions)  on either a
Form S-1, Form S-2 or Form S-3  Registration  Statement under the Securities Act
of 1933,  as amended  (the  "Securities  Act").  The  Company  is not,  however,
required to register any Registrable  Securities unless such shares represent at
least 10% of the Company's  outstanding shares of Common Stock, or, if less than
10%, if the anticipated aggregate offering price exceeds $1,000,000.

     The holders of Registrable  Securities  also have the right to an unlimited
number of  registrations  on Form S-3 under the  Securities  Act. The Company is
not,  however,  required to effect  such a  registration  unless the  requesting
holders reasonably  anticipate having an aggregate disposition price of at least
$500,000.

     Also  pursuant  to the  Rights  Agreement,  if,  at  any  time  during  the
seven-year  period  commencing  on the effective  date of the Company's  initial
public offering,  the Company proposes to register any of its Common Stock under
the  Securities  Act for sale to the  public,  the  holders  of the  Registrable
Securities  have  unlimited  piggyback  registration  rights  at  the  Company's
expense, subject to certain restrictions set forth in the Rights Agreement.

     Also in September  1995, the Company  granted to the then holders of Series
A,  Series  B  and  Series  C  Redeemable  Preferred  Stock  certain  rights  to
participate in certain future offerings  undertaken by the Company.  Such rights
to participate require that, with certain exceptions including,  but not limited
to, an underwritten  public  offering,  any time the Company  proposes to issue,
sell or exchange,  or reserve therefor,  any securities,  the Company must first
offer to sell to each of the  pre-conversion  holders of Series A,  Series B and
Series C  Redeemable  Preferred  Stock their  respective  pro rata share of such
securities  at a price  and on terms  identical  to the  price  and terms of the
securities proposed to be issued, sold or exchanged in the applicable offering.


                                      -10-
<PAGE>

PERFORMANCE GRAPH

     The following graph compares the cumulative total stockholder return on the
Company's  Common Stock with the cumulative total return on the Nasdaq Composite
Index and the Nasdaq  Pharmaceutical  Index  (capitalization  weighted)  for the
period  beginning on the date on which the  Securities  and Exchange  Commission
declared  effective the Company's Form 8-A  Registration  Statement  pursuant to
Section 12 of the Exchange Act and ending on the last day of the Company's  last
completed fiscal year.

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

              Among the Company, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)




                                [Graph goes here]



<TABLE>
<CAPTION>




        Company/         Base Period    December       June      December      June      December
       Index Name         June 1996       1996         1997        1997        1998        1998
       ----------         ---------       ----         ----        ----        ----        ----
<S>                         <C>       <C>         <C>           <C>         <C>          <C>      
CGPI................        $100      $  89.04    $   131.51    $ 136.99    $   94.52    $  105.48
NASDAQ..............         100        110.46        123.67      135.61    $  162.98    $  190.29
NASDAQ PHAR.........         100         98.41        101.11      101.87    $  104.04    $  130.72

</TABLE>

- -----------

(1)  Graph assumes $100 invested on June 20, 1996 in the Company's Common Stock,
     the   Nasdaq   Composite   Index  and  the  Nasdaq   Pharmaceutical   Index
     (capitalization weighted).

(2)  Total return assumes reinvestment of dividends.

(3)  Year ended December 31.



                                      -11-
<PAGE>

COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     The Compensation Committee has furnished the following report:

     The Compensation Committee is composed of three non-employee directors. The
Compensation Committee recommends,  and the Board approves, all matters relating
to  executive   compensation,   including  setting  and  administering  policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The  Compensation  Committee meets twice annually to set performance  objectives
for the Chief Executive Officer ("CEO") and to determine the annual compensation
of the CEO and other senior  executives  of the Company.  The CEO is not present
during the discussion of his compensation.

Executive Compensation Policy
- -----------------------------

     The goal of the Company's  executive  compensation policy is to ensure that
an  appropriate  relationship  exists  between  executive  compensation  and the
creation of stockholder  value,  while at the same time attracting and retaining
qualified  senior  management.  Historically,  the  Company  has  operated  as a
"virtual"  pharmaceutical  company  with a small  number of  highly  experienced
senior  executives  determining  and  executing  the  Company's  strategy  while
contracting out pharmaceutical  development  activities to clinical research and
other third party  organizations.  More recently,  however,  the Company has and
will  continue  to expand its sales and  marketing  infrastructure.  In order to
continually attract highly experienced  executives,  the Company's  compensation
packages  for  senior  executives  are  highly  competitive  with  those paid to
executives of other emerging pharmaceutical companies.

Compensation Mix
- ----------------

     The  Company's  executive  compensation  packages  generally  include three
components: base salary, a discretionary annual cash bonus and stock options.

Base Salary
- -----------

     The  Compensation  Committee  seeks to  establish  base  salaries  for each
position  and  level of  responsibility  which  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

Discretionary Cash Bonus
- ------------------------

     The Compensation  Committee  believes that  discretionary  cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

Stock Options
- -------------

     Stock option grants under the Company's  stock option plans are designed to
align the long term  interests  of the  Company's  executives  with those of its
stockholders  by rewarding  executives for  increasing  stockholder  value.  All
executive  officers are awarded option grants upon joining the Company which are
competitive  with those at  comparable  emerging  pharmaceutical  companies.  In
addition,  the  Compensation  Committee may award additional stock option grants
annually.  When granting stock options, the Compensation Committee considers the
recommendation  of the  Company's  Chief  Executive  Officer  and  the  relative
performance and contributions of each officer compared to that of other officers
within the Company with similar levels of responsibility.

Compensation of the Chief Executive Officer
- -------------------------------------------

     In establishing  Dr.  Gallagher's  compensation  package,  the Compensation
Committee  seeks  to  maintain  a level of total  current  compensation  that is
competitive  with  that paid to chief  executive  officers  of other  comparable
emerging   pharmaceutical   companies.  In  addition,  in  order  to  align  Dr.
Gallagher's  interests  with the  interests of

                                      -12-
<PAGE>

the  Company's  stockholders,  the  Compensation  Committee  attempts  to make a
substantial  portion  of the value of his total  compensation  dependent  on the
appreciation of the Company's stock price.

     Dr.  Gallagher's  performance  is  evaluated  annually by the  Compensation
Committee  against a stated  list of  short,  medium  and long  term  objectives
developed  by the  Compensation  Committee  at the  beginning  of each  year and
approved by the Board of Directors.  Based on his achievements relating to these
objectives,  the Compensation Committee  recommended,  and the board approved, a
bonus to Dr.  Gallagher  of  $75,000  for  1998,  which is paid in 1999,  and an
increase in base salary from $262,500 to $268,000 effective January 1, 1999.

     Section 162(m) of the Internal Revenue Code disallows the  deductibility by
the  Company of any  compensation  over $1 million  paid to the Chief  Executive
Officer  or any of the other four most  highly  compensated  executives,  unless
certain  criteria are satisfied.  The Company's Chief Executive  Officer and the
other named  executives have not received annual  compensation  over $1 million,
and the  Company has not  determined  what  measures,  if any, it should take to
comply with Section 162.

                                          Compensation Committee Members:

                                          Robert J. Easton
                                          Stephen W. Ritterbush, Ph.D.
                                          Terence E. Winters, Ph.D.


                                      -13-
<PAGE>


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     There are, as of February 15, 1999, approximately 118 holders of record and
3,000 beneficial holders of the Company's Common Stock. The following table sets
forth certain information,  as of February 15, 1999, with respect to holdings of
the  Company's  Common  Stock by (i) each person  known by the Company to be the
beneficial  owner of more than 5% of the total  number of shares of Common Stock
outstanding  as of such  date,  (ii)  each  of the  Company's  directors  (which
includes  all  nominees)  and Named  Executives,  and (iii)  all  directors  and
officers as a group.
<TABLE>
<CAPTION>

                                                                  Amount and Nature of               Percent
Name and Address of Beneficial Owner(1)                           BeneficialOwnership(1)            of Class(2)
- ---------------------------------------                           ----------------------            -----------
<S>                                                                      <C>                          <C>
(i)      Certain Beneficial Owners:
Zesiger Capital Group LLC
320 Park Avenue, 30th Floor
New York, New York 10022...............................                    972,300                      11.3%
Columbine Venture Fund II, L.P.
6155 N. Scottsdale Road, Suite 100
Scottsdale, Arizona 85250..............................                    969,328                      11.3
Marquette Venture Partners II, L.P.
  and MVP II Affiliates Fund, L.P.
520 Lake Cook Road, Suite 450
Deerfield, Illinois 60015..............................                    916,313(3)                   10.7
Thomson Horstmann & Bryant, Inc.
Park 80 West Plaza Two
Saddle Brook, NJ 07663.................................                    613,600                       7.1
Delphi Ventures III, L.P. and
  Delphi  Investments III, L.P.
3000 Sand Hill Road
Building 1, Suite 135
Menlo Park, California 94025...........................                    510,000(4)                    5.9
Fairfax Partners/The Venture Fund
  of Washington, L.P.
1568 Spring Hill Road, Suite 200
McLean, Virginia 22102.................................                    446,517                       5.2
(ii)     Directors (which includes all nominees) and
         Named Executives:
Brian M. Gallagher, Ph.D...............................                    412,500(5)                    4.6
Robert A. Ashley.......................................                    150,725(6)                    1.7
Nancy C. Broadbent.....................................                    124,000(7)                    1.4
Douglas C. Gehrig......................................                     70,500(8)                    *
David F. Pfeiffer......................................                     70,000(8)                    *
Helmer P.K. Agersborg, Ph.D............................                    126,209(9)                    1.5
Peter R. Barnett, D.M.D................................                     12,000(10)                   *
James E. Daverman......................................                    926,313(11)                  10.8
Robert J. Easton.......................................                     41,689(12)                   *
Stephen W. Ritterbush, Ph.D............................                    456,517(13)                   5.3
Pieter J. Schiller.....................................                    400,299(14)                   4.7
Terence E. Winters, Ph.D...............................                    979,328(15)                  11.4
(iii)    All Directors and officers as a
         group (12 persons)............................                  3,770,080(16)                  40.4%
</TABLE>

                                      -14-
<PAGE>

- -----------

*  Less than 1%

(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable community property law, the persons named in the table have sole
     voting and investment power with respect to all shares.

(2)  Applicable  percentage  of ownership  for each holder is based on 8,589,704
     shares of Common Stock  outstanding  on February 15, 1999,  plus any Common
     Stock equivalents and presently  exercisable stock options or warrants held
     by each such holder, and options or warrants held by each such holder which
     will become exercisable within 60 days after February 15, 1999.

(3)  Includes  890,860  shares  and 25,453  shares  owned by  Marquette  Venture
     Partners II, L.P. and MVP II Affiliates Fund, L.P., respectively.

(4)  Includes 500,968 shares and 9,032 shares owned by Delphi Ventures III, L.P.
     and Delphi Investments III, L.P., respectively.

(5)  Of such shares, 125,000 are subject to certain rights of first refusal held
     by the Company.  See "EXECUTIVE  COMPENSATION -- Summary of Compensation in
     fiscal  1998,  1997 and  1996".  Includes  287,500  shares of Common  Stock
     underlying  options which are or may be exercisable as of February 15, 1999
     or 60 days after such date.

(6)  Includes 122,500 shares of Common Stock underlying options which are or may
     be exercisable as of February 15, 1999 or 60 days after such date.

(7)  Includes 99,000 shares of Common Stock underlying  options which are or may
     be  exercisable  as of February  15, 1999 or 60 days after such date.  Also
     includes 1,000 shares held as custodian to minor child.

(8)  Includes 69,000 shares of Common Stock underlying  options which are or may
     be exercisable as of 2/15/99 or 60 days after such date.

(9)  Includes  37,500  shares  of  Common  Stock  underlying  options  which are
     exercisable as of February 15, 1999 or 60 days after such date.

(10) Includes  10,000  shares  of  Common  Stock  underlying  options  which are
     exercisable as of February 15, 1999 or 60 days after such date.

(11) James E. Daverman is President of Marquette Management  Partners,  LLC, the
     general partner of Marquette Venture  Partners,  L.P. and a general partner
     of MG II, L.P., the general partner of Marquette  Venture Partners II, L.P.
     and MVP II Affiliates  Fund,  L.P.  and, as such,  has the power to vote or
     direct  the vote of and to  dispose  of or direct  the  disposition  of the
     shares owned by Marquette  Venture  Partners II, L.P. and MVP II Affiliates
     Fund, L.P. Mr. Daverman expressly  disclaims  beneficial  ownership of such
     shares,  except  as to his  proportionate  interest  in  Marquette  Venture
     Partners II, L.P. and MVP II Affiliates  Fund, L.P.  Includes 10,000 shares
     of Common Stock underlying options which are exercisable as of February 15,
     1999 or 60 days after such date.

(12) Includes  10,000  shares  of  Common  Stock  underlying  options  which are
     exercisable  as of  February  15,  1999 or 60 days after  such  date.  Also
     includes  6,400 shares held as trustee for Second Easton Family  Charitable
     Trust.

(13) Stephen W. Ritterbush,  Ph.D. is a general partner of Fairfax  Partners/The
     Venture Fund of  Washington,  L.P.  and, as such,  has the power to vote or
     direct  the vote of and to  dispose  of or direct  the  disposition  of the
     shares owned by Fairfax Partners/The  Venture Fund of Washington,  L.P. Dr.
     Ritterbush expressly disclaims beneficial ownership of such shares,  except
     as to his proportionate  interest in Fairfax  Partners/The  Venture

                                      -15-
<PAGE>

     Fund of Washington,  L.P. Includes 10,000 shares of Common Stock underlying
     options which are exercisable as of February 15, 1999 or 60 days after such
     date.

(14) Pieter J.  Schiller is a general  partner of Advanced  Technology  Ventures
     III, L.P. and, as such,  has the power to vote or direct the vote of and to
     dispose  of or direct  the  disposition  of the  shares  owned by  Advanced
     Technology Ventures III, L.P. Mr. Schiller expressly  disclaims  beneficial
     ownership  of such  shares,  except  as to his  proportionate  interest  in
     Advanced  Technology  Ventures III, L.P.  Includes  10,000 shares of Common
     Stock  underlying  options which are exercisable as of February 15, 1999 or
     60 days after such date.

(15) Terence E. Winters,  Ph.D. is a general  partner of Columbine  Venture Fund
     II, L.P.  and, as such,  has the power to vote or direct the vote of and to
     dispose  of or direct the  disposition  of the  shares  owned by  Columbine
     Venture Fund II, L.P. Dr. Winters expressly disclaims  beneficial ownership
     of such  shares,  except  as to his  proportionate  interest  in  Columbine
     Venture Fund II, L.P.  Includes  10,000  shares of Common Stock  underlying
     options which are exercisable as of February 15, 1999 or 60 days after such
     date.

(16) See Notes 5 through 15.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     As of April 1, 1999, each of Advanced  Technology  Ventures III, L.P., with
which Mr. Schiller is affiliated,  and Marquette  Venture  Partners II, L.P. and
MVP II  Affiliates  Fund,  L.P.,  with which Mr.  Daverman is  affiliated,  held
390,299, 890,860 and 25,453 shares, respectively,  of the Company's Common Stock
which were previously issued upon conversion of the Company's Series A Preferred
Stock,  Series B Preferred Stock and Series C Preferred Stock previously held by
each such entity. Such entities are,  therefore,  with respect to such shares of
Common  Stock,  entitled  to the  identical  registration  rights  and rights to
participate in certain future offerings undertaken by the Company as are Fairfax
Partners/The  Venture Fund of  Washington,  L.P.,  with which Dr.  Ritterbush is
affiliated  and  Columbine  Venture  Fund II,  L.P.,  with which Dr.  Winters is
affiliated.

     For  information   concerning  such  registration   rights  and  rights  to
participate  in certain  future  offerings  undertaken by the Company,  and with
respect  to Drs.  Ritterbush  and  Winters,  each a member  of the  Compensation
Committee.  See "EXECUTIVE COMPENSATION -- Compensation Committee Interlocks and
Insider Participation."

     In March 1999, each of Robert J. Easton and Marquette  Venture Partners II,
L.P. and MVP II Affiliates Fund, L.P. executed a Stock Purchase  Agreement and a
Stockholders  and  Registration  Rights  Agreement with respect to the purchase,
upon  requisite  stockholder  approval,  of  shares  of the  Company's  Series D
Preferred Stock. See "Series D Preferred Stock Issuance Proposal."

                         1996 STOCK OPTION PLAN PROPOSAL

     The 1996  Stock  Option  Plan was  adopted  by the Board of  Directors  and
approved  by the  Stockholders  of the  Company on March 22,  1996 and March 29,
1996,  respectively.  Those  eligible to receive  stock  option  grants or stock
purchase  rights  under  the  1996  Stock  Option  Plan  include  the  Company's
employees, directors and consultants. The 1996 Stock Option Plan was adopted to

     o    attract  and retain the best  available  personnel  for  positions  of
          substantial responsibility;

     o    provide additional  incentives to employees,  members of the Board and
          consultants of the Company and its subsidiaries; and

     o    promote the success of the Company's business.

Currently  there are 750,000  shares of Common Stock  reserved for issuance upon
the exercise of options  and/or stock  purchase  rights  granted  under the 1996
Stock Option Plan.

                                      -16-
<PAGE>

     The 1996 Stock Option Plan is administered by the  Compensation  Committee,
which is  comprised  solely of outside  directors.  The  Compensation  Committee
determines, among other things, the

     o    nature of the options to be granted;

     o    persons, or grantees, who are to receive options;

     o    number of shares to be subject to each option;

     o    exercise price of the options; and

     o    vesting schedule of the options.

     The 1996 Stock Option Plan provides for the granting of options intended to
qualify as incentive  stock  options,  or ISOs, as defined in Section 422 of the
Internal Revenue Code of 1986, as amended, to employees of the Company. The 1996
Stock Option Plan also provides for the granting of non-qualified stock options,
or NQSOs,  to  employees,  non-employee  directors and  consultants  who perform
services for the Company or its  subsidiaries.  The  exercise  price of all ISOs
granted  under the 1996 Stock  Option  Plan may not be less than the fair market
value of the shares at the time the option is granted.  In addition,  no ISO may
be granted to an employee  who owns more than 10% of the total  combined  voting
power of all classes of stock of the  Company  unless the  exercise  price as to
that employee is at least 110% of the fair market value of the stock at the time
of the grant.  No employee  may be granted  ISOs which are  exercisable  for the
first time in any calendar year to the extent that the aggregate  exercise value
of such option shares exceeds  $100,000 as of the date of grant.  Options may be
exercisable  for a period  of not more  than ten  years  from the date of grant,
provided,  however  that the term of an ISO granted to an employee who owns more
that 10% of the  total  combined  voting  power of all  classes  of stock of the
Company may not exceed five years. The exercise price of NQSOs granted under the
1996 Stock  Option  Plan may not be less than 85% of the fair  market  value per
share of the  Common  Stock on the date of grant.  No NQSO may be  granted  to a
person who owns more than 10% of the total combined  voting power of all classes
of stock of the  Company  unless the  exercise  price to that person is at least
110% of the fair  market  value  of the  stock  at the  time of the  grant.  The
exercise  price must be paid in full at the time an option is exercised,  and at
the Compensation  Committee's discretion,  all or part of the exercise price may
be paid with previously  owned shares or other approved  methods of payment.  An
option is  exercisable  as determined by the  Compensation  Committee.  The 1996
Stock Option Plan will terminate on March 28, 2006.

     Subject to the terms as specified in any option  agreement,  the  following
time table applies with respect to exercising  outstanding  vested  options if a
grantee's employment or consulting relationship is terminated:

   Reason for termination
   during term of employment
   or consulting relationship                  Latest exercise date
   --------------------------                  --------------------

Disability                          One year following termination by grantee
Death                               One year following death by grantee's estate
Any other reason                    90 days following termination by grantee

     Options are not assignable or otherwise  transferable except by will or the
laws of descent and distribution  and shall be exercisable  during the grantee's
lifetime only by the grantee.

     The 1996 Stock  Option  Plan also  permits the  awarding of stock  purchase
rights at not less  than 50% of the fair  market  value of the  shares as of the
date offered.  The 1996 Stock Option Plan requires the execution of a restricted
stock purchase  agreement in a form  determined by the  Compensation  Committee.
Once a stock purchase right is exercised,  the purchaser will have the rights of
a shareholder.  The purchaser will be a shareholder when the purchase is entered
on the Company's records.



                                      -17-
<PAGE>

     The 1996 Stock Option Plan provides that in the event of a

o  reorganization;                       o  recapitalization;
o  stock split;                          o  stock dividend;
o  combination of or reclassification    o  or any other change in the corporate
   of shares;                               structure or shares of the Company,

the Board of Directors  shall make  adjustments  with respect to the shares that
may be  issued  under  the  1996  Stock  Option  Plan or  that  are  covered  by
outstanding options, or in the option price per share.

     The Board  shall  notify  the  grantee  at least  fifteen  days  prior to a
dissolution  or  liquidation  of  the  Company.  The  outstanding  options,  not
previously  exercised,  will terminate  immediately prior to the consummation of
such proposed  action.  In the event of a merger or consolidation of the Company
or the sale of all or  substantially  all of the Company's  assets (a "merger"),
the  outstanding  options  will  be  assumed  or an  equivalent  option  will be
substituted  by such  successor  corporation  or a parent or  subsidiary of such
successor  corporation.  If such successor  corporation does not agree to assume
the  outstanding  options  or to  substitute  equivalent  options,  the Board of
Directors  will,  in lieu of such  assumption or  substitution,  provide for the
grantee to have the right to exercise  all of his  outstanding  options.  If the
Board of Directors  makes an option fully  exercisable  in lieu of assumption or
substitution,  in the event of a merger, the Board of Directors shall notify the
grantee that the option will be fully  exercisable  for a period of fifteen days
from the date of such notice,  and the option will terminate upon the expiration
of such period.  The option will be considered assumed if, following the merger,
the option confers the right to purchase, for each share of Common Stock subject
to the option immediately prior to the merger, the consideration (whether stock,
cash,  or other  securities  or  property)  received in the merger by holders of
Common Stock for each share held on the effective date of the  transaction  (and
if holders were  offered a choice of  consideration,  the type of  consideration
chosen  by the  holders  of a  majority  of the  outstanding  shares).  If  such
consideration  received  in the  merger  was  not  solely  common  stock  of the
successor  corporation  or its  parent,  the Board of  Directors  may,  with the
consent  of the  successor  corporation  and the  participant,  provide  for the
consideration  to be received  upon the  exercise of an option for each share of
stock  subject  to the  option  to be  solely  common  stock  of  the  successor
corporation  or  its  parent  equal  in  fair  market  value  to the  per  share
consideration  received  by  holders  of Common  Stock in the  merger or sale of
assets.

     The Board may at any time amend,  alter,  suspend or  discontinue  the 1996
Stock Option Plan, but no such action will be made which would impair the rights
of any grantee under any grant previously made,  without such grantee's consent.
In addition,  to the extent  necessary  and  desirable to comply with Rule 16b-3
under the Exchange Act, or with Section 422 of the Code (or any other applicable
law or regulation,  including the  requirements  of the National  Association of
Securities  Dealers or an established stock exchange),  the Company shall obtain
shareholder  approval of any 1996 Stock  Option Plan  amendment in such a manner
and to such a degree as required.  Any such amendment or termination of the 1996
Stock Option Plan is not permitted to affect  options  already  granted and such
options  will  remain in full force and effect as if the 1996 Stock  Option Plan
had not been amended or terminated, unless mutually agreed otherwise between the
grantee  and the Board of  Directors,  which  agreement  must be in writing  and
signed by the grantee and the Company.

FEDERAL INCOME TAX ASPECTS

     (a)  Incentive Stock Options

     Some  options  to be  issued  under  the 1996  Stock  Option  Plan  will be
designated  as ISOs and are intended to qualify  under  Section 422 of the Code.
Under the  provisions of that Section and the related  regulations,  an optionee
will not be required to recognize any income for Federal  income tax purposes at
the time of grant of an ISO.  Additionally,  the Company will not be entitled to
any deduction.  The exercise of an ISO also is not a taxable event, although the
difference  between the option  price and the fair  market  value on the date of
exercise is an item of tax  preference for purposes of the  alternative  minimum
tax. The taxation of gain or loss upon the sale of stock  acquired upon exercise
of an ISO depends in part on whether the stock is disposed of at least two years
after the date the

                          -18-
<PAGE>
option  was  granted  and at  least  one year  after  the  date  the  stock  was
transferred to the optionee, referred to as the ISO Holding Period.

     If the ISO  Holding  Period  is not met,  then,  upon  disposition  of such
shares,  referred to as a disqualifying  disposition,  the optionee will realize
compensation,  taxable as ordinary  income,  in an amount equal to the excess of
the fair  market  value of the  shares at the time of  exercise  over the option
price,  limited,  however,  to the gain on sale.  Any  additional  gain would be
taxable as capital  gain (see  discussion  of capital  gains  under the  section
relating  to  NQSOs,  below).  If  the  optionee  disposes  of the  shares  in a
disqualifying  disposition at a price that is below the fair market value of the
shares  at the time the ISO was  exercised  and  such  disposition  is a sale or
exchange to an unrelated party, the amount includible as compensation  income to
the optionee will be limited to the excess of the amount received on the sale or
exchange over the exercise price.

     If  the  optionee   recognizes   ordinary   income  upon  a   disqualifying
disposition,  the Company  generally  will be entitled to a tax deduction in the
same amount.

     Effective as of January 1, 1998, the holding  period for long-term  capital
gain treatment is reduced to one year.  Hence, if the ISO Holding Period is met,
any  disposition  on or after  January 1, 1998  would be taxable as a  long-term
capital gain or loss; any such gains are taxable at a maximum rate of 20%.

     A maximum  capital  gains  rate of 18% will apply to  certain  sales  after
December 31, 2000 of shares  acquired upon the exercise of an ISO if such shares
have been held for at least five years.

     If the ISO is  exercised by delivery of  previously  owned shares of Common
Stock in partial  or full  payment  of the  option  price,  no gain or loss will
ordinarily  be  recognized  by the optionee on the  transfer of such  previously
owned shares.  However, if the previously owned transferred shares were acquired
through the exercise of an ISO, the  optionee may realize  ordinary  income with
respect to the shares used to exercise  an ISO if such  transferred  shares have
not been held for the ISO Holding  Period.  If an ISO is  exercised  through the
payment of the  exercise  price by the delivery of Common  Stock,  to the extent
that the number of shares  received  exceeds  the number of shares  surrendered,
such excess shares will possibly be considered ISO stock with a zero basis.

     (b)  Non-Qualified Stock Options

     Some  options  to be  issued  under  the 1996  Stock  Option  Plan  will be
designated  as NQSOs.  If (as in the case of NQSOs  granted under the 1996 Stock
Option Plan at this time) the NQSO does not have a "readily  ascertainable  fair
market value" at the time of the grant, the NQSO is not included as compensation
income at the time of grant.  Rather, the optionee realizes  compensation income
only when the NQSO is exercised and the optionee has become substantially vested
in the shares transferred.  The shares are considered to be substantially vested
when they are  either  transferable  or not  subject  to a  substantial  risk of
forfeiture.  The  amount of income  realized  is equal to the excess of the fair
market value of the shares at the time the shares  become  substantially  vested
over the sum of the exercise price plus the amount, if any, paid by the optionee
for the NQSO. If a NQSO is exercised  through  payment of the exercise  price by
the delivery of Common Stock,  to the extent that the number of shares  received
by the optionee exceeds the number of shares  surrendered,  ordinary income will
be realized  by the  optionee at that time only in the amount of the fair market
value of such excess  shares,  and the tax basis of such  excess  shares will be
such fair  market  value.  When the  optionee  disposes  of the shares  acquired
pursuant to a NQSO,  the optionee will  recognize  capital gain or loss equal to
the  difference  between the amount  received for the shares and the  optionee's
basis on the shares.

     Under the 1996 Stock Option Plan, the  optionee's  basis in the shares will
be the  exercise  price plus the  compensation  income  realized  at the time of
exercise.  Under tax legislation  which became  effective as of January 1, 1998,
the capital gain or loss will be short-term (with gains generally subject to tax
as  ordinary  income) if the shares  are  disposed  of within one year after the
option is  exercised  and long term (with  gains  generally  subject to tax at a
maximum  rate of 20%) if the shares are disposed of more than one year after the
option is exercised.

                                      -19-
<PAGE>
     A maximum  capital  gains rate of 18% will apply to  certain  sales,  after
December  31,  2000,  of shares  acquired  upon the  exercise of an NQSO if such
shares have been held for at least five years.

     The Company is generally entitled to a deductible  compensation  expense in
an amount  equivalent  to the  amount  included  as  compensation  income to the
optionee.  This deduction is allowed in the Company's  taxable year in which the
income is included as compensation to the optionee.

     Except as  otherwise  indicated,  the  preceding  discussion  is based upon
Federal tax laws and  regulations  in effect on the date of the  preparation  of
this Summary,  which are subject to change,  and upon an  interpretation  of the
relevant  sections of the Code, their  legislative  histories and the income tax
regulations which interpret  similar  provisions of the Code.  Furthermore,  the
forgoing is only a general  discussion of the Federal  income tax aspects of the
1996 Stock Option Plan and does not purport to be a complete  description of all
Federal income tax aspects of the 1996 Stock Option Plan.  Optionees may also be
subject to state and local  taxes in  connection  with the grant or  exercise of
options  granted  under  the  1996  Stock  Option  Plan  and the  sale or  other
disposition of shares  acquired upon exercise of the options.  Each key employee
receiving a grant of options should consult with his or her personal tax advisor
regarding the Federal,  state and local tax consequences of participating in the
1996 Stock Option Plan.

PREVIOUSLY GRANTED OPTIONS UNDER THE 1996 STOCK OPTION PLAN

     As of March 31,  1999,  the  Company  had  granted  options to  purchase an
aggregate of 749,950(1)  shares of Common Stock under the 1996 Stock Option Plan
at an average  exercise price of $9.51 per share. As of March 31, 1999,  184,212
options to purchase  shares  were  vested and no options to purchase  shares had
been exercised  under the 1996 Stock Option Plan. The following table sets forth
the  options  granted  under  the  1996  Stock  Option  Plan  to (i)  the  Named
Executives;  (ii) all current executive  officers as a group; (iii) each nominee
for election as a Director;  (iv) all current  Directors  who are not  executive
officers as a group;  (v) each  associate  of any of such  Directors,  executive
officers or  nominees;  (vi) each person who has received or is to receive 5% of
such options or rights; and (vii) all employees,  including all current officers
who are not executive officers, as a group:
<TABLE>
<CAPTION>

                                                      Options Granted
                                                          through           Weighted Average
                      Name                            March 31, 1999         Exercise Price        Expiration Date
- ---------------------------------------------         --------------         --------------        ---------------
<S>                                                      <C>                     <C>                 <C>    <C>   
Brian M. Gallagher, Ph.D.....................            125,000                 $7.35               2/2007-2/2008
Robert A. Ashley.............................             50,000                 $7.63               2/2007-2/2008
Nancy C. Broadbent...........................             50,000                 $7.63               2/2007-2/2008
Douglas C. Gehrig............................             80,000                 $9.53               7/2007-2/2008
David F. Pfeiffer............................             80,000                 $9.53               7/2007-2/2008
All current executive officers as a group
   (5 persons)...............................            385,000                 $8.33               2/2007-2/2008
All current Directors who are not executive
   officers as a group (7 persons)...........                 --                   --                      --
All employees, including all current
   officers who are not executive officers,
   as a group (137 persons)(4)...............            364,950                $10.75              11/2006-2/2009
</TABLE>

     As of March 31, 1999,  the market value of the Common Stock  underlying the
1996 Stock Option Plan was $[ ] per share.

- -----------

(1)  Of the 749,950 options granted as of March 31, 1999,  3,000 of such options
     have been canceled and may be reissued by the Company.



                                      -20-
<PAGE>

(2)  Options are granted  under the 1996 Stock  Option Plan  pursuant to various
     vesting schedules.  In general,  such options vest over two (2) to five (5)
     year periods.

(3)  All 142 of the  Company's  employees  are eligible to  participate  in 1996
     Stock Option Plan.

(4)  Includes  two (2)  consultants  who were  granted  options to  purchase  an
     aggregate of 40,000  shares of Common Stock at an exercise  price of $12.19
     per share with an expiration date of February 2009.

Each of the following individuals holds more than five-percent (5%) of the total
options  issuable under the 1996 Stock Option Plan:  Brian M.  Gallagher,  Ph.D.
(16.67%);  Robert A. Ashley  (6.67%);  Nancy C.  Broadbent  (6.67%);  Douglas C.
Gehrig (10.67%) and David F. Pfeiffer (10.67%).

PROPOSED AMENDMENT

     Stockholders are being asked to consider and vote upon a proposed amendment
(the  "Amendment")  to the 1996 Stock Option Plan to increase the maximum number
of shares of Common Stock  available  for  issuance  under the 1996 Stock Option
Plan from  750,000 to  1,500,000  shares and to  reserve an  additional  750,000
shares of Common  Stock of the Company for  issuance in  connection  with awards
granted under the 1996 Stock Option Plan.

     The Board of Directors  believes that the  Amendment  provides an important
inducement  to recruit  and retain the best  available  personnel.  The Board of
Directors believes that providing employees with an opportunity to invest in the
Company rewards them appropriately for their efforts on behalf of the Company.

     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE APPROVAL OF THE AMENDMENT.


                                      -21-
<PAGE>

                   SERIES D PREFERRED STOCK ISSUANCE PROPOSAL

     Stockholders are being asked to consider and vote upon a proposal to issue,
pursuant to a private placement (the "Private  Placement"),  200,000 shares (the
"Preferred  Shares") of Series D  Preferred  Stock at a price per share of $100.
The Series D Preferred  Stock is  initially  convertible  into an  aggregate  of
1,818,182 shares of Common Stock, or approximately 21.2% of the currently issued
and  outstanding  shares of Common  Stock.  The Private  Placement  includes the
issuance of 177,000 shares of Series D Preferred  Stock,  initially  convertible
into 1,609,091 shares of Common Stock (or  approximately  18.7% of the currently
issued  and  outstanding  shares of Common  Stock),  to a single  investor,  OCM
Principal  Opportunities Fund, L.P. ("OCM"). Among the purchasers of the balance
of the shares are Robert J.  Easton,  a Director of the Company,  and  Marquette
Venture  Partners  II,  L.P.  ("Marquette")  and MVP II  Affiliates  Fund,  L.P.
("MVP"),  together  the  beneficial  owners of more  than 5% of the  outstanding
shares of Common Stock.  James E.  Daverman,  a Director of the Company,  is the
President of the General  Partner of Marquette  and MVP.  Based on the number of
shares to be issued (on an as-converted to Common Stock basis), certain dividend
provisions of the Preferred Shares and other rights and preferences thereof, the
Company,  pursuant to The Nasdaq Stock Market,  Inc.'s Marketplace Rules 4310(c)
and (d), seeks to obtain stockholder approval of the Private Placement.

     As indicated in the Company's Quarterly Report on Form 10-Q for the quarter
ended  September 30, 1998 and the  Company's  Annual Report on Form 10-K for the
year ended December 31, 1998, the Company is in need of additional  financing to
fund the  Company's  actual and planned  operations.  At December 31, 1998,  the
Company had $10,250,317 of cash and cash equivalents.

     The  Company  has  incurred  losses  each year since  inception  and had an
accumulated  deficit of $37,928,591 at December 31, 1998. The Company expects to
continue  to incur  losses in the near  future  from  expenditures  on sales and
marketing,  manufacturing,  drug development and administrative  activities. The
Company currently estimates that cash on hand at December 31, 1998 together with
the proceeds of the Debt Financing (as  hereinafter  defined) and cash generated
from operations will be sufficient to satisfy the Company's cash requirements at
least  through  December  31,  1999.  The  Board  of  Directors  of the  Company
considered various means of procuring  financing and has determined that, at the
present time, the Private  Placement is in the best interests of the Company and
its  stockholders.  The  Company  believes  that  it may  be  required  to  seek
additional  financing  in the future to fund its  operations  and to continue to
develop its products.

STOCK PURCHASE AGREEMENT

     On March 19, 1999,  the Company  executed a Stock  Purchase  Agreement (the
"Purchase  Agreement") with six (6) investors  pursuant to which the Company has
agreed  to  issue  the  Preferred  Shares  for an  aggregate  purchase  price of
$20,000,000.  The  Preferred  Shares,  which  have the  rights  and  preferences
described below, are initially convertible into an aggregate of 1,818,182 shares
of Common Stock, or approximately  21.2% of the currently issued and outstanding
shares of Common Stock. The consummation of the Private Placement is subject to,
among other  things,  approval of the  transaction  by the  stockholders  of the
Company.  If approved by the stockholders of the Company, it is anticipated that
the  closing  of the  Private  Placement  would  occur  as soon  as  practicable
thereafter.  Simultaneously  with the execution of the Purchase  Agreement,  the
purchasers  and the Company  executed a  Stockholders  and  Registration  Rights
Agreement (the "Stockholders  Agreement"),  the material provisions of which are
described below.

DEBT FINANCING

     On March 19, 1999,  the Company  completed a private  placement of a Senior
Secured  Convertible  Note (the "Note") to OCM (the "Debt  Financing"),  raising
$10,000,000 in gross  proceeds.  The Note will pay interest at 12% per annum and
is due and payable on March 18, 2000.  The Note must be prepaid upon the closing
of the Private Placement.  In the event the Private Placement is not consummated
by June 30,  1999,  the holder of the Note shall have the option to convert  the
principal  due under the Note,  at a conversion  price of $6.50 per share,  into
1,538,462  shares of Common  Stock.  The accrued  interest due under the Note is
also  convertible into shares of Common Stock at a conversion price of $6.50 per
share.  The shares of Common Stock issued upon conversion of


                                      -22-
<PAGE>

the Note would have registration  rights similar to those granted to the holders
of the  Preferred  Shares.  See "- the Series D Preferred  Stock -  Information,
Registration and Other Rights" below.

VOTING AGREEMENT

     Certain stockholders of the Company,  including Brian M. Gallagher,  Ph.D.,
Nancy C. Broadbent,  Robert A. Ashley,  Henry P.K.  Agersborg,  Ph.D., Robert J.
Easton, Zesiger Capital Group LLC (on its own behalf and as trustee on behalf of
certain  stockholders),  Columbine  Venture  Fund II,  L.P.,  Marquette  Venture
Partners II, L.P., MVP II Affiliates Fund,  L.P.,  Delphi Ventures III, L.P. and
Delphi  Investments  III,  L.P.  and  Fairfax   Partners/The   Venture  Fund  of
Washington,  L.P.,  owning in the  aggregate  4,764,580  shares of Common  Stock
(approximately  55.2%  of the  currently  outstanding  shares  of  Common  Stock
entitled  to vote at the  Meeting)  have  agreed to vote in favor of the Private
Placement.

THE SERIES D PREFERRED STOCK

     Appendix  A  attached  hereto  is  the  proposed  form  of  Certificate  of
     -----------
Designation, Preferences and Rights of Series D Cumulative Convertible Preferred
Stock (the "Designation").  The following is a summary of the Designation and of
the rights and preferences of the Series D Preferred Stock.

     Designation and Amount.  Preferred  Stock of the Company  designated as the
"Series D Cumulative  Convertible  Preferred  Stock" (herein  referred to as the
"Series D Preferred  Stock"),  having a par value per share equal to $.01,  with
the number of shares constituting such series is 200,000.

     Dividends.  During the first three years  after the date of  issuance,  the
holders of the  outstanding  shares of Series D Preferred Stock will be entitled
to receive,  out of funds legally available  therefor,  an 8.4% annual dividend,
equal in value to $8.40 per  share,  payable  on each July 31 and  January 31 in
registered  shares of Common Stock (valued at 100% of the average  trading price
on the Nasdaq National Market for the five trading days immediately prior to the
dividend  declaration  date).  After such three-year  period, the holders of the
outstanding shares of Series D Preferred Stock will be entitled to receive,  out
of funds legally available therefor, an 8% annual cash dividend,  equal in value
to $8.00 per share, payable on each July 31 and January 31.

     Conversion  by  Holders.  Each  share of Series D  Preferred  Stock will be
convertible,  at the  option of its  holder,  at any time after  issuance,  into
shares of Common Stock  determined  by dividing  $100 by the  conversion  price,
which  initially  shall be $11 per share,  for each share of Series D  Preferred
Stock converted.

     Voting  Rights.  The Series D  Preferred  Stock  shall be  entitled to vote
together  with the holders of the Common  Stock on all matters to be voted on by
the Company,  on an  as-converted  to Common  Stock  basis.  The approval of the
holders  of at least 66 2/3% of the Series D  Preferred  Stock is  required  for
certain  actions by the Company,  including  creating or issuing  stock  ranking
senior to the Series D Preferred  Stock or issuing  securities  during the first
year after the original issuance of the Series D Preferred Stock at a price less
than the  conversion  price then in effect.  The  approval  of the holders of at
least a majority of the Series D Preferred Stock is required for certain actions
by the Company,  including  paying  dividends  (other than those on the Series D
Preferred  Stock),  incurring  indebtedness in excess of $10,000,000 for working
capital  purposes,  disposing  of assets of the Company  (except in the ordinary
course of  business),  acquisitions  in any  calendar  year  period in excess of
$10,000,000  and making  research and  development  expenditures in any 12-month
period in excess of  $7,000,000  unless the Company has  reported net income for
four consecutive quarters.

     Conversion by the Company.  Each share of Series D Preferred  Stock will be
convertible,  at the option of the Company,  into shares of Common Stock, at the
applicable  conversion  rate, at any time after the Common Stock has traded at a
price per share of at least 200% above the  conversion  price then in effect for
40  consecutive  trading  days,  provided  that the shares of Common Stock to be
issued upon such conversion are registered  under the Securities Act of 1933, as
amended.

                                      -23-
<PAGE>

     Adjustment  of  Conversion  Price.  The  conversion  price of the  Series D
Preferred  Stock  shall be  adjusted,  on a  weighted  average  basis,  upon the
issuance of  securities,  options or warrants at a price per share less than the
then effective conversion price.

     Redemption.   Each  outstanding  share  of  Series  D  Preferred  Stock  is
redeemable,  at the option of the Company as follows: at $100 per share plus all
accrued and unpaid  dividends  if less than 5% of the Series D  Preferred  Stock
originally issued are outstanding; at $120 per share plus all accrued and unpaid
dividends  in the event of a change in control of the Company  between the third
and fifth anniversaries of the date of issuance of the Series D Preferred Stock;
and at $100 per share plus accrued and unpaid dividends in the event of a change
in control of the Company after the fifth anniversary of the date of issuance of
the Series D Preferred Stock.

     Board  Representation.  The holders of the Series D Preferred Stock will be
entitled to elect one director to the Board of  Directors  of the  Company.  The
maximum size of the Board of Directors is set at nine members.

     Default  Dividends.  The  dividend  payable to the  holders of the Series D
Preferred Stock shall be doubled upon an event of default,  which is defined as,
among other things,  default on the payment of dividends,  material  breaches of
the Purchase Agreement or the Stockholders Agreement, the filing of a bankruptcy
petition by or against the Company,  acceleration  of  indebtedness in excess of
$1,000,000,  a change in control of the  Company,  or the  failure of the Common
Stock to actively trade on the American Stock Exchange,  New York Stock Exchange
or the Nasdaq  National  Market.  The  Company is  entitled  to pay the  default
dividends  in shares of Common  Stock in the event the  Company  cannot pay cash
dividends  because of a deficiency in cash or a prohibition  under Delaware law,
such that a cash payment would have a material adverse effect on the Company.

     Additional  Dividends.  If dividends are not paid on the required  dividend
payment  dates  (July  31  and  January  31),  accrued  dividends  shall  accrue
additional  dividends at double the applicable dividend rate (16.8% or 16.0%, as
the case may be).

     Adjustment of Conversion  Price.  In the event the Company fails to declare
dividends after the Company has been notified of an event of default for failure
to pay  dividends,  the holders of a majority  of the Series D  Preferred  Stock
shall  have the  option to elect to have the  conversion  price of the  Series D
Preferred  Stock reset to the then fair market  value of the Common Stock (based
upon the five-day trailing average closing price of the Common Stock).

     Liquidation,  Dissolution  or Winding Up. In the event of any  liquidation,
dissolution or winding up of the Company, whether voluntary or involuntary,  the
holders of outstanding  shares of Series D Preferred  Stock shall be entitled to
receive  out of the assets of the  Company  available  for  distribution  to its
stockholders,  an amount equal to $100.00 per share of Series D Preferred  Stock
plus all cumulative dividends, whether or not earned or declared.

     Information,  Registration  and Other Rights.  Pursuant to the Stockholders
Agreement,  the  Company has agreed to furnish OCM with  certain  financial  and
business information,  including monthly, quarterly and annual financial reports
and annual budgets and operating forecasts.  The Company has granted OCM a right
of first refusal to purchase certain  securities issued after twelve (12) months
from the date of issuance of the Series D Preferred Stock in the event the price
per share of such  securities is less than the conversion  price then in effect.
The Company has  granted  the  holders of the Series D Preferred  Stock  certain
demand and  piggyback  registration  rights  with  respect  to the Common  Stock
issuable upon conversion of the Series D Preferred  Stock.  The Company also has
agreed to file a shelf  registration  statement  for the shares of Common  Stock
issuable  upon  conversion  of the  Series D  Preferred  Stock and the shares of
Common Stock issuable as dividends on the Series D Preferred Stock.



                                      -24-
<PAGE>

                                 CAPITALIZATION

     The following table sets forth the total capitalization of the Company: (i)
as of December  31,  1998;  (ii) pro forma to give effect to the issuance of the
Note;  and (iii) pro forma as adjusted to give effect to the sale by the Company
of 200,000  shares of the Series D Preferred  Stock in the Private  Placement at
the offering  price of $100 per share and the  application  of the estimated net
proceeds therefrom  (including repayment of the Note), after deducting estimated
offering expenses.
<TABLE>
<CAPTION>

                                                                          As of December 31, 1998
                                                            -------------------------------------------------------
                                                                                                      Pro Forma As
                                                             Actual              Pro Forma              Adjusted
                                                             ------              ---------              --------

                                                                               (in thousands)

<S>                                                         <C>                   <C>                <C>    
Short-term debt..................................           $    --               $  10,000          $    --
                                                            ===========           =========          =======
Stockholders' Equity:
    Preferred  Stock,  $0.01 par value,  5,000,000
      shares authorized;  none issued and outstanding
      on an actual  and pro  forma  basis and  200,000
      shares issued  and outstanding on a pro forma as
      adjusted basis..............................                --                     --                 2
                                                            -----------            ---------        ---------
    Common Stock, $0.01 par value, 25,000,000
     shares authorized; 8,587,204 shares issued and
     outstanding on an actual, pro forma and pro
     forma as adjusted basis, respectively.......                    86                   86               86
    Additional paid-in capital...................                47,317               47,317           65,915
    Deferred compensation........................                  (194)                (194)            (194)
    Accumulated Deficit .........................               (37,928)             (37,928)         (37,928)
                                                                -------              -------          -------
     Total shareholders' equity .................           $     9,281           $    9,281          $27,881
                                                            ===========           ==========          =======
</TABLE>

     THE BOARD OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE APPROVAL OF THE PRIVATE
PLACEMENT.

                INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

     The information appearing under the captions  "Management's  Discussion and
Analysis of Financial  Condition  and Results of  Operations"  and the Company's
Consolidated  Balance  Sheets as of December 31, 1998 and December 31, 1997, and
the  Consolidated  Statements of Operations and the  Consolidated  Statements of
Stockholders' Equity (Deficit), each for the years ended December 31, 1998, 1997
and 1996 and the independent  auditors'  report on such  consolidated  financial
statements  contained in the Annual Report accompanying this Proxy Statement are
incorporated herein by reference to such portions of such Annual Report.

               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

     The Board of  Directors  of the  Company  intends,  subject to  Stockholder
approval, to retain KPMG LLP as independent auditors of the Company for the year
ending  December 31, 1999.  KPMG LLP also served as independent  auditors of the
Company  for 1998.  Neither  the firm nor any of its  members  has any direct or
indirect  financial  interest  in the Company.

     THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF KPMG LLP AS THE INDEPENDENT  AUDITORS OF THE COMPANY FOR THE YEAR
ENDING DECEMBER 31, 1999.

     One or more  representatives  of KPMG LLP is expected to attend the Meeting
and have an  opportunity  to make a  statement  and/or  respond  to  appropriate
questions from stockholders.


                                      -25-
<PAGE>

                             STOCKHOLDERS' PROPOSALS

     Stockholders  who wish to submit  proposals  for inclusion in the Company's
proxy  statement  and  form of proxy  relating  to the 2000  Annual  Meeting  of
Stockholders  must  advise the  Secretary  of the Company of such  proposals  in
writing by December 14, 1999.

                                  OTHER MATTERS

     The Board of  Directors  is not aware of any  matter  to be  presented  for
action at the  Meeting  other than the  matters  referred  to above and does not
intend to bring any other matters before the Meeting.  However, if other matters
should come before the Meeting,  it is intended that holders of the proxies will
vote thereon in their discretion.

                                     GENERAL

     The  accompanying  proxy is  solicited  by and on  behalf  of the  Board of
Directors  of the  Company,  whose  notice of meeting is  attached to this Proxy
Statement,  and the  entire  cost  of such  solicitation  will be  borne  by the
Company.

     In addition to the use of the mails,  proxies may be  solicited by personal
interview,  telephone and telegram by directors, officers and other employees of
the  Company  who will not be  specially  compensated  for these  services.  The
Company  will  also  request  that  brokers,  nominees,   custodians  and  other
fiduciaries forward soliciting materials to the beneficial owners of shares held
of record by such  brokers,  nominees,  custodians  and other  fiduciaries.  The
Company will reimburse such persons for their reasonable  expenses in connection
therewith.

     Certain  information  contained  in this Proxy  Statement  relating  to the
occupations  and security  holdings of directors  and officers of the Company is
based upon information received from the individual directors and officers.

     COLLAGENEX  PHARMACEUTICALS,  INC. WILL FURNISH,  WITHOUT CHARGE, A COPY OF
ITS  REPORT  ON FORM  10-K FOR THE  YEAR  ENDED  DECEMBER  31,  1998,  INCLUDING
CONSOLIDATED  FINANCIAL  STATEMENTS  AND  SCHEDULE  THERETO  BUT  NOT  INCLUDING
EXHIBITS,  TO EACH OF ITS  STOCKHOLDERS OF RECORD ON MARCH 26, 1999, AND TO EACH
BENEFICIAL  STOCKHOLDER  ON THAT DATE UPON WRITTEN  REQUEST MADE TO MS. NANCY C.
BROADBENT, SECRETARY, COLLAGENEX PHARMACEUTICALS,  INC., 301 SOUTH STATE STREET,
NEWTOWN,  PENNSYLVANIA  18940.  A  REASONABLE  FEE WILL BE CHARGED FOR COPIES OF
REQUESTED EXHIBITS.

     PLEASE DATE, SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST CONVENIENCE IN
THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN  OF YOUR  PROXY  CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.

                                            By Order of the Board of Directors


                                            Nancy C. Broadbent,
                                            Secretary
Newtown, Pennsylvania
April 12, 1999

                                      -26-
<PAGE>
                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
              OF THE COMPANY FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned hereby  constitutes and appoints Brian M. Gallagher,  Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of  Stockholders  of the Company to be held at the Marriott  Hotel,  1201 Market
Street, Philadelphia, Pennsylvania at 8:30 A.M., local time, on Tuesday, May 11,
1999,  and at any  adjournment  or  adjournments  thereof,  upon  the  following
proposals more fully  described in the Notice of Annual Meeting of  Stockholders
and Proxy Statement for the Meeting (receipt of which is hereby acknowledged).

     THIS  PROXY WHEN  PROPERLY  EXECUTED  WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1, 2, 3 AND 4.

                    (continued and to be signed on reverse side)



<PAGE>


                 Please Detach and Mail In the Envelope Provided


A [X]Please mark your votes as in this example.

1.   ELECTION OF             FOR         WITHHELD   Nominees:
     DIRECTORS.              [  ]          [   ]    Helmer P.K. Agersborg, Ph.D.
     VOTE FOR all the nominees listed at right;     Brian M. Gallagher, Ph.D.
     except vote withheld from the following        James E. Daverman
     nominee(s) (if any).                           Pieter J. Schiller
                                                    Peter R. Barnett, D.M.D
                                                    Robert J. Easton
                                                    Stephen W. Ritterbush, Ph.D.
                                                    Terrence E. Winters. Ph.D.
     ------------------------------
2.   APPROVAL  OF  PROPOSAL  TO AMEND THE  COMPANY'S  1996 STOCK  OPTION PLAN TO
     INCREASE THE MAXIMUM  AGGREGATE  NUMBER OF SHARES OF COMMON STOCK AVAILABLE
     FOR  ISSUANCE  THEREUNDER  FROM 750,000  SHARES TO 1,500,000  SHARES AND TO
     RESERVE AN  ADDITIONAL  750,000  SHARES OF COMMON  STOCK OF THE COMPANY FOR
     ISSUANCE IN  CONNECTION  WITH AWARDS  GRANTED  UNDER THE 1996 STOCK  OPTION
     PLAN.

          FOR                 AGAINST                  ABSTAIN
        [     ]              [       ]                 [      ]

3.   TO APPROVE THE  CONSUMMATION  OF A PRIVATE  PLACEMENT  FOR AGAINST  ABSTAIN
     PURSUANT TO WHICH THE COMPANY  SHALL  ISSUE  SHARES OF SERIES D  CUMULATIVE
     CONVERTIBLE  PREFERRED  STOCK,  $.01 PAR VALUE,  REPRESENTING  21.2% OF THE
     ISSUED AND OUTSTANDING EQUITY SECURITIES OF THE COMPANY.

          FOR                 AGAINST                  ABSTAIN
        [     ]              [       ]                 [      ]

4.   APPROVAL  OF  PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF  KPMG  LLP  AS THE
     INDEPENDENT AUDITORS OF THE COMPANY FOR THE YEAR ENDING DECEMBER 31, 1999.

          FOR                 AGAINST                  ABSTAIN
        [     ]              [       ]                 [      ]


5.   In his or her  discretion,  the  proxy is  authorized  to vote  upon  other
     matters as may properly come before the Meeting.

                              I will              I will not
                              [    ]              [        ]
                                   attend the Meeting.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY,  USING THE ENCLOSED
ENVELOPE.

Signature of Stockholder           Signature of Stockholder         Dated:
                        ----------                         --------       ------
                                                    IF HELD JOINTLY

NOTE: THIS PROXY MUST BE SIGNED EXACTLY AS THE NAME APPEARS HEREON.  WHEN SHARES
      ARE  HELD  BY  JOINT  TENANTS,  BOTH  SHOULD  SIGN.  IF  THE  SIGNER  IS A
      CORPORATION,  PLEASE SIGN FULL CORPORATE NAME BY DULY AUTHORIZED  OFFICER,
      GIVING FULL TITLE AS SUCH. IF THE SIGNER IS A PARTNERSHIP,  PLEASE SIGN IN
      PARTNERSHIP NAME BY AUTHORIZED PERSON.




<PAGE>

                                   APPENDIX A
                           CERTIFICATE OF DESIGNATION
<PAGE>


                                                                     Appendix A


              CERTIFICATE OF DESIGNATION, PREFERENCES AND RIGHTS
              OF SERIES D CUMULATIVE CONVERTIBLE PREFERRED STOCK
                                       OF
                        COLLAGENEX PHARMACEUTICALS, INC.

          CollaGenex   Pharmaceuticals,   Inc.,  a  Delaware   corporation  (the
"Corporation"),  pursuant  to the  provisions  of  Section  151  of the  General
Corporation  Law of the State of Delaware  (the  "DGCL"),  does hereby make this
Certificate of Designation  under the corporate seal of the Corporation and does
hereby state and certify that pursuant to the  authority  vested in the Board of
Directors of the Corporation by the Certificate of  Incorporation,  the Board of
Directors has duly adopted the following resolutions:

          RESOLVED,  that  pursuant  to  Article  Fifth  of the  Certificate  of
Incorporation,  as amended (which authorizes five million  (5,000,000) shares of
Preferred  Stock,  par value $0.01 per share,  none of which is presently issued
and  outstanding),  the Board of  Directors  hereby fixes the  designations  and
preferences  and relative  participating,  optional and other special rights and
qualifications,  limitations  and  restrictions  of a series of Preferred  Stock
consisting of 200,000 shares to be designated as Series D Cumulative Convertible
Preferred Stock.

Series D Convertible Preferred Stock
- ------------------------------------

          RESOLVED,   that  the  holders  of  Series  D  Cumulative  Convertible
Preferred Stock, except as otherwise provided by law, shall have and possess the
following rights and preferences.

A. Series D Convertible Preferred Stock.
   ------------------------------------

          1. DESIGNATION, NUMBER OF SHARES. This series of Preferred Stock shall
be  designated as Series D Cumulative  Convertible  Preferred  Stock  ("Series D
Preferred  Stock"),  and the number of shares that shall  constitute such series
shall be 200,000.  The par value of Series D Preferred  Stock shall be $0.01 per
share.

          2. RANK.  With respect to dividend  rights and rights on  liquidation,
winding up and  dissolution of the  Corporation,  Series D Preferred Stock shall
rank senior to:

          (i) the Common Stock, par value $0.01 per share ("Common  Stock"),  of
the Corporation; and

          (ii) each other class of capital stock or class or series of preferred
stock  issued by the  Corporation  after the date  hereof  (in  accordance  with
Paragraph  A.8.(b)(ii)  hereof),  the terms of which shall specifically  provide
that such class or series  shall rank junior to Series D  Preferred  Stock as to
dividend  distributions  or  distributions  upon  liquidation,  winding  up  and
dissolution of the  Corporation  (each of the securities in clauses (i) and (ii)
above collectively referred to as "Junior Securities").

     3. DIVIDEND PROVISIONS.

          (a) Each  holder of Series D  Preferred  Stock  shall be  entitled  to
receive,  when,  as and if  declared  by the  Board of  Directors,  out of funds
legally available therefor,  dividends on each share of Series D Preferred Stock
as follows:  (i) during the first three (3) years after the date of the original
issuance of the Series D Preferred  Stock (the "Common Stock Dividend  Period"),
the Company  shall pay such  dividends at a rate equal to eight and  four-tenths
percent  (8.4%) per share per annum in fully  paid,  registered,  non-assessable
shares of Common  Stock which shares of such Common Stock shall be valued at one
hundred  percent  (100%) of the  average  trading  price on the Nasdaq  National
Market  ("NASDAQ")  for the  five  (5)  trading  days  immediately  prior to the
Dividend  Declaration  Date (as defined in Paragraph B. hereof);  and (ii) after
the Common Stock Dividend  Period,  the Company shall pay cash dividends on each
share of Series D  Preferred  Stock at a rate  equal to eight  percent  (8%) per
share per annum.  At all times,  dividends  paid in cash shall be paid at a rate
equal to eight  percent  (8%)

<PAGE>

per share per annum and  dividends  paid in Common Stock shall be paid at a rate
of eight and four-tenths percent (8.4%) per share per annum.

          (b) All  dividends,  whether  payable  in cash or in  shares of Common
Stock, shall be cumulative,  whether or not earned or declared, and shall accrue
on a daily  basis  beginning  on the date of the  original  issuance of Series D
Preferred Stock (whether or not funds are legally  available for the declaration
and/or payment of such dividends), and shall be payable semi-annually in arrears
on each Dividend Payment Date (as defined in Paragraph B. hereof), commencing on
the first Dividend Payment Date after the date of the original  issuance of such
Series D Preferred  Stock.  Each  dividend on Series D Preferred  Stock shall be
payable to the holders of record of Series D  Preferred  Stock as they appear on
the stock register of the Corporation on such record date as may be fixed by the
Board of  Directors,  which record date shall not be less than ten (10) nor more
than sixty (60) calendar days prior to the applicable Dividend Payment Date.

          (c)  Commencing  on the  sixth  (6th)  anniversary  of the date of the
original  issuance of the Series D Preferred  Stock,  the annual  dividend  rate
referenced  above in Paragraph  A.3.(a)  shall  increase by one percent (1%) per
annum until the earlier of the date that all of the shares of Series D Preferred
Stock are (i) converted into shares of Common Stock in accordance with Paragraph
A.5. hereof, or (ii) redeemed in accordance with Paragraph A.6. hereof.

          (d) Dividends shall cease to accrue in respect of any shares of Series
D  Preferred  Stock on the date such  shares are (i)  converted  into  shares of
Common Stock in accordance with Paragraph A.5.  hereof,  or (ii) are redeemed in
accordance with Paragraph A.6. hereof.

          (e) Accrued  dividends on the Series D Preferred Stock, if not paid on
the first or any  subsequent  Dividend  Payment Date  following  accrual,  shall
thereafter  accrue  additional  dividends  ("Additional  Dividends")  in respect
thereof,  compounded  semi-annually,   at  the  rate  specified  hereinabove  in
Paragraph  A.3.(a)  hereof or as  specified  hereinbelow  in  Paragraph  A.3.(h)
hereof;  during the first six (6) years after the date of the original  issuance
of the Series D Preferred Stock, and at the applicable  increased  dividend rate
for each year thereafter.

          (f) All  dividends  paid with  respect to shares of Series D Preferred
Stock  pursuant to  Paragraph  A.3.(a)  shall be paid pro rata to the holders of
Series D Preferred Stock of record entitled thereto.

          (g) Dividends on account of arrears for any past  Dividend  Period may
be declared  and paid at any time,  without  reference  to any regular  Dividend
Payment Date,  to the holders of Series D Preferred  Stock of record on any date
as may be fixed by the Board of  Directors,  which date is not more than  thirty
(30) calendar days prior to the payment of such dividends.

          (h) The dividend payable to holders of Series D Preferred Stock as set
forth above in Paragraph  A.3.(a)  shall be doubled (the  "Default  Dividends"),
which Default  Dividends  shall be payable in either cash or Common Stock at the
choosing  of each  holder of Series D Preferred  Stock upon the  occurrence  and
during  the  continuance  of any of the  following  events  (each an  "Event  of
Default" and  collectively  the "Events of  Default")  not cured or not curable,
upon the giving of written notice thereof to the Corporation by the holders of a
majority of the shares of Series D Preferred Stock then outstanding:

               (i) in the event that the  Corporation  does not (A)  declare the
dividend  payable on the shares of Series D Preferred Stock within (30) calendar
days  of the  Dividend  Declaration  Date,  (B)  fulfill  its  dividend  payment
obligation in full for the Series D Preferred Stock, as set forth herein, within
thirty (30) calendar days after said dividend payment is due and payable, or (C)
fulfill its dividend  payment  obligation in the form of either cash or stock as
required herein; or

               (ii) in the event  that the  Corporation  shall  have  materially
breached any of the representations and warranties contained in any of the Stock
Purchase Agreement or the Stockholders and Registration Rights Agreement and any
registration statement filed by the Company in relation thereto; or


                                      -2-
<PAGE>

               (iii) in the event that the  Corporation  shall  have  materially
breached  any of the  covenants  or  agreements  contained  in any of the  Stock
Purchase  Agreement or the Stockholders  and  Registration  Rights Agreement and
such  breach  shall not have been cured to the  satisfaction  of the  holders of
record of a majority of the shares of Series D Preferred Stock then  outstanding
within  thirty  (30)  calendar  days  after the date of giving of notice of such
breach to the Corporation; or

               (iv) in the event of the  acceleration of any indebtedness of the
Corporation   with  a  principal   amount  in  excess  of  One  Million  Dollars
($1,000,000); or

               (v) in  the  event  of  the  receipt  of a  final  non-appealable
judgment against the Corporation in an amount that is uninsured in excess of One
Million Dollars ($1,000,000); or

               (vi) in the  event  that the  Corporation  shall (A) apply for or
consent  to the  appointment  of a  receiver,  trustee  or  liquidator  for  the
Corporation  or any of its  property;  (B) admit in writing its inability to pay
debts  as  they  mature;  (C)  make a  general  assignment  for the  benefit  of
Creditors;  (D) be  adjudicated  bankrupt  or  insolvent;  (E) file a  voluntary
petition  in  bankruptcy,  a petition  or answer  seeking  reorganization  or an
arrangement with creditors to take advantage of any bankruptcy,  reorganization,
insolvency,  readjustment of debt, dissolution or liquidation law or statute, or
an answer  admitting the material  allegations of a petition filed against it in
any  proceeding  under any such law; or (F) have  failed to have an  involuntary
petition in bankruptcy  filed against it dismissed and  discharged  within sixty
(60)  calendar  days after the date of such filing;  corporate  actions shall be
taken for the purpose of effecting any of the foregoing;  or an order,  judgment
or decree shall be entered without the  application,  approval or consent of the
Corporation,  by any  court of  competent  jurisdiction,  approving  a  petition
seeking reorganization of the Corporation or of all or a substantial part of its
assets, and such order, judgment or decree shall continue unstayed and in effect
for sixty (60) calendar days (a "Bankruptcy"); or

               (vii)  in the  event  that  either  (A) any  court  of  competent
jurisdiction  finds that any of the patents owned or licensed by the Corporation
are invalid in any material respect; or (B) any of the patents owned or licensed
by the Corporation materially infringe upon any other patent; provided, however,
                                                              --------  -------
that in the event of either (A) or (B), Investor, in good faith, determines that
such finding will have a Material Adverse Effect on the Corporation; or

               (viii) if at any time after the date the first  share of Series D
Preferred  Stock is issued,  shares of Common  Stock are not  actively  publicly
traded on the American Stock Exchange, NASDAQ or NYSE; or

               (ix) in the event that the Corporation consolidates or merges the
Corporation  with or into any  other  corporation  or  corporations,  or  sells,
conveys or disposes of all or substantially all of the assets of the Corporation
or enters into a  transaction  or series of related  transactions  in which more
than fifty  percent  (50%) of the  voting  power of the  Corporation  is sold or
otherwise disposed of (a "Change in Control").

     In  addition  to the  foregoing,  in the event that the Board of  Directors
continues to fail to declare and pay accrued  dividends and/or Default Dividends
on the  shares of  Series D  Preferred  Stock  after  the  Corporation  has been
notified of an Event of Default in accordance with Paragraph  A.3.(h)(i) hereof,
which is not curable or has not been cured within the period of time  prescribed
for the  Corporation  to  effectuate  such a cure,  the  holders  of record of a
majority of shares of Series D Preferred Stock shall have the option, during the
continuance of such an Event of Default,  to elect to have the Conversion  Price
reset to the then fair market value of the Common Stock of the  Corporation,  as
determined  by using  the five (5) day  trailing  average  closing  price of the
Common  Stock of the  Corporation,  as  reported  on  NASDAQ.  Any  reset of the
Conversion  Price hereunder shall be effective on the day immediately  after the
date of the holders' notice to the Corporation.

     Notwithstanding the foregoing,  in the event that the Corporation is unable
to meet its  obligation to pay cash dividends in the form of cash because of (a)
a deficiency  in the cash position of the  Corporation  such that the payment of
such dividends in cash would have a Material  Adverse Effect on the Corporation,
or (b) a


                                      -3-
<PAGE>

prohibition by the DGCL, then the Corporation  shall be permitted to pay Default
Dividends in shares of Common Stock during such time the condition  described in
this paragraph continues.

          (i) The  holders of Series D  Preferred  Stock  shall be  entitled  to
receive the dividends  provided for in Paragraph A.3.(a) hereof in preference to
and in  priority  over any  dividends  upon any of the Junior  Securities.  Such
dividends on the Series D Preferred  Stock shall be  cumulative,  whether or not
earned  or  declared,  so that if at any time  full  Accumulated  Dividends  (as
defined in Paragraph B. of this  Agreement)  on all shares of Series D Preferred
Stock then  outstanding have not been paid for all Dividend Periods then elapsed
and a prorated  dividend on the Series D Preferred  Stock at the rate  aforesaid
from the Dividend Payment Date immediately preceding the Junior Payment Date (as
defined  below) to the Junior  Payment  Date have not been paid or set aside for
payment,  the amount of such unpaid dividends shall be paid before any sum shall
be set aside for or applied by the  Corporation  to the purchase,  redemption or
other acquisition for value of any shares of Junior Securities  (either pursuant
to any  applicable  sinking fund  requirement  or  otherwise) or any dividend or
other  distribution  shall be paid or declared  and set apart for payment on any
Junior Securities (the date of any such actions to be referred to as the "Junior
Payment  Date");  provided,  however,  that the  restrictions  set forth in this
                  --------   -------
sentence  shall  not  apply to the  purchase  or  other  acquisition  of  Junior
Securities  pursuant to any  employee or director  incentive  or benefit plan or
arrangement (including any employment, severance or consulting agreement) of the
Corporation  or  any  subsidiary  of the  Corporation  heretofore  or  hereafter
adopted.

          (j) Dividends  payable on Series D Preferred Stock for any period less
than one (1) year shall be computed on the basis of a 360-day year consisting of
twelve  30-day  months plus the actual  number of calendar  days  elapsed in the
month for which such dividends are payable.

     4. LIQUIDATION PREFERENCE.  Upon any voluntary or involuntary  liquidation,
dissolution  or  winding  up of the  Corporation,  the  holders of all shares of
Series D Preferred  Stock then  outstanding  shall be entitled to be paid out of
the assets of the Corporation  available for distribution to its stockholders an
amount in cash equal to One Hundred Dollars ($100.00) in cash per share, plus an
amount equal to full  cumulative  dividends  (whether or not earned or declared)
accrued  and  unpaid  thereon,   including   Default  Dividends  and  Additional
Dividends,   to  the  date  of  final  distribution  and  no  more,  before  any
distribution is made on any Junior Securities. After payment in full pursuant to
this  Paragraph  A.4.,  the  holders of Series D  Preferred  Stock  shall not be
entitled  to any  further  participation  in any  distribution  in the  event of
liquidation, dissolution or winding up of the affairs of the Corporation.

     5. CONVERSION.

          (a) RIGHT OF CONVERSION.  Each share of Series D Preferred Stock shall
be convertible,  at the option of the holder thereof, at any time, and from time
to  time,  after  the date of  issuance  of such  share,  at the  office  of the
Corporation  or any transfer agent for the Series D Preferred  Stock,  into such
number of fully paid,  registered,  non-assessable  shares of Common Stock as is
determined by dividing One Hundred  Dollars  ($100.00) by the Conversion  Price.
The "Conversion  Price" for the Series D Preferred Stock shall be Eleven Dollars
($11.00) per share.  The Conversion Price for the Series D Preferred Stock shall
be subject to adjustment as set forth in Paragraph A.5.(c) hereof.

          (b) PROCEDURES FOR VOLUNTARY  CONVERSION.  Before any holder of shares
of Series D Preferred Stock shall be entitled to convert any of such shares into
shares  of  Common  Stock,  such  holder  shall  surrender  the  certificate  or
certificates therefor, duly endorsed, at the office of the Corporation or of any
transfer agent for the Series D Preferred  Stock,  and shall give written notice
by mail, postage prepaid, or hand delivery,  to the Corporation at its principal
corporate  office,  of the election to convert the same and shall state  therein
the name or names in which the certificate or certificates  for shares of Common
Stock  are  to  be  issued.  The  Corporation  shall,  as  soon  as  practicable
thereafter, issue and deliver at such office to such holders of shares of Series
D Preferred Stock, or to the nominee or nominees of such holders,  a certificate
or  certificates  for the number of shares of Common  Stock to which such holder
shall be entitled as  aforesaid.  Such  conversion  shall be deemed to have been
made immediately prior to the close of business on the date of such surrender of
the  shares of  Series D  Preferred  Stock to be  converted,  and the  person or
persons  entitled  to receive  the  shares of Common  Stock  issuable

                                      -4-
<PAGE>

upon such  conversion  shall be treated for all purposes as the record holder or
holders of such shares of Common Stock as of such date. If the  conversion is in
connection with an underwritten  offering of securities  registered  pursuant to
the Securities Act of 1933, as amended, the conversion may, at the option of any
holder  tendering the Series D Preferred  Stock for  conversion,  be conditioned
upon the effectiveness of such offering,  in which event the person(s)  entitled
to receive Common Stock issuable upon such  conversion of the Series D Preferred
Stock shall not be deemed to have converted such Series D Preferred  Stock until
immediately  prior to the  effectiveness  of such  offering and the  Corporation
shall deliver to such holders  tendering Series D Preferred Stock for conversion
written notice of the anticipated  date of such  effectiveness  no less than ten
(10) calendar days prior thereto.

          (c) ADJUSTMENTS OF CONVERSION PRICE. So long as any shares of Series D
Preferred Stock are outstanding,  the Conversion Price of the Series D Preferred
Stock shall be subject to adjustment from time to time as follows:

               (i)  (A)  Upon  issuance  (or  deemed  issuance  pursuant  to the
provisions hereof) by the Corporation of any Additional Stock (as defined below)
after the date of issuance of Series D Preferred Stock, without consideration or
for an Effective Price per share, or, in the case of Convertible  Securities,  a
conversion  price per  share,  less than the  Conversion  Price for the Series D
Preferred Stock in effect immediately prior to the issuance (or deemed issuance)
of such Additional  Stock,  then the Conversion Price for the Series D Preferred
Stock in effect  immediately  prior to each (such  issuance or deemed  issuance)
shall be adjusted,  if the issuance  occurs after the initial  twelve (12) month
period after the date of original issuance of the Series D Preferred Stock, to a
price determined by the following  formula:  (A + B) / (C + D), where "A" equals
the  number  of shares of Common  Stock  outstanding  immediately  prior to such
issuance or sale multiplied by the then applicable  Conversion Price,  where "B"
equals the consideration, if any, received by the Corporation upon such issuance
or sale, where "C" equals the total number of shares of Common Stock outstanding
prior to issuance of the  additional  shares and where "D" equals any Additional
Stock or any conversion  shares, or any other shares reserved for issuance which
are associated with such financing, immediately after such issuance or sale. See
Exhibit A hereto for an example of the formula set forth herein.

                    (B) No  adjustment  of the  Conversion  Price  for  Series D
Preferred  Stock  shall be made in an  amount  less  than  one-half  of One Cent
($0.005) per share,  provided that any adjustments  which are not required to be
made by reason of this sentence shall be carried forward and shall be taken into
account in any subsequent  adjustment to the Conversion  Price. No adjustment of
the Conversion Price for the Series D Preferred Stock pursuant to this Paragraph
A.5.(c)(i)  shall have the effect of increasing  such  Conversion  Price for the
Series D Preferred Stock above the Conversion Price in effect  immediately prior
to such adjustment.

                    (C) In  the  case  of  the  issuance  of  securities  of the
Corporation  for cash, the amount of  consideration  received by the Corporation
for such  securities  shall be  deemed to be the  amount  of cash paid  therefor
before deducting any discounts,  commissions or other expenses allowed,  paid or
incurred by the Corporation for any underwriting or otherwise in connection with
the issuance and sale thereof.

                    (D) In  the  case  of  the  issuance  of  securities  of the
Corporation  for a  consideration  in  whole or in part  other  than  cash,  the
consideration  other than cash shall be deemed to have a dollar  value  equal to
the  fair  market  value of such  non-cash  consideration,  irrespective  of any
accounting  treatment  thereof,  as  determined by a vote of the majority of the
Board of  Directors  including  the  affirmative  vote of the Series D Preferred
Director.

                    (E) In the case of the issuance (whether before, on or after
the date of  issuance  of Series D  Preferred  Stock) of Options or  Convertible
Securities,  the  following  provisions  shall  apply for all  purposes  of this
Paragraph A.5.(c)(i) and Paragraph A.5.(c)(ii) hereof:

          (1) With respect to Options to purchase  Common  Stock,  the aggregate
          maximum number of shares of Common Stock  deliverable upon exercise of
          such  Options  shall be deemed  to have  been  issued at the time such
          Options were issued and for a consideration equal to the consideration
          (determined in the manner provided in Subparagraph

                                      -5-
<PAGE>

          A.5.(c)(i)(C) and Subparagraph A.5.(c)(i)(D) hereof), if any, received
          by the  Corporation  for such Options plus the minimum  exercise price
          provided in such Options for Common Stock issuable thereunder.

          (2) With  respect to  Convertible  Securities  and Options to purchase
          Convertible  Securities,  the  aggregate  maximum  number of shares of
          Common Stock  deliverable  upon the conversion or exchange of any such
          Convertible  Securities and the aggregate  maximum number of shares of
          Common  Stock  issuable  upon the exercise of such Options to purchase
          Convertible  Securities and the  subsequent  conversion or exchange of
          such Convertible Securities shall be deemed to have been issued at the
          time such Convertible Securities or such Options were issued and for a
          consideration  equal to the  consideration,  if any,  received  by the
          Corporation for any such Convertible  Securities and Options, plus the
          minimum  additional  consideration,  if  any,  to be  received  by the
          Corporation  upon  the  conversion  or  exchange  of such  Convertible
          Securities  or the  exercise  of such  Options and the  conversion  or
          exchange of the Convertible  Securities issuable upon exercise of such
          Options (the consideration in each case to be determined in the manner
          provided in Subparagraphs A.5.(c)(i)(C) and A.5.(c)(i)(D) hereof).

          (3) In the event of any change in the number of shares of Common Stock
          deliverable, or in the consideration payable to the Corporation,  upon
          exercise  of such  Options  or upon  conversion  or  exchange  of such
          Convertible  Securities,  including,  but not  limited  to,  a  change
          resulting from the  antidilution  provisions  thereof,  the Conversion
          Price of the  Series  D  Preferred  Stock,  to the  extent  in any way
          affected by or computed using such Options or Convertible  Securities,
          shall be recomputed to reflect such change,  but no further adjustment
          shall be made for the actual  issuance of Common  Stock or any payment
          of such  consideration  upon the  exercise of any such  Options or the
          conversion or exchange of such Convertible Securities.

          (4) Upon the expiration or termination of any such Options or any such
          rights to convert or exchange Convertible  Securities,  the Conversion
          Price of the  Series  D  Preferred  Stock,  to the  extent  in any way
          affected by or computed using such Options or Convertible  Securities,
          shall be  recomputed  to reflect  the  issuance  of only the number of
          shares of Common Stock (and Options and Convertible  Securities  which
          remain in effect) that were actually  issued upon the exercise of such
          Options  or upon  the  conversion  or  exchange  of  such  Convertible
          Securities.

          (5) The  number  of  shares  of Common  Stock  deemed  issued  and the
          consideration   deemed  paid   therefor   pursuant  to   Subparagraphs
          A.5.(c)(i)(E)(1)  and (2) hereof  shall be  appropriately  adjusted to
          reflect any change, termination or expiration of the type described in
          either Subparagraph A.5.(c)(i)(E)(3) or (4) hereof.

               (ii) "Additional  Stock" shall mean any shares of Common Stock or
shares of Common Stock  issuable  pursuant to Convertible  Securities  issued or
Options  (or deemed to have been  issued  pursuant  to  Paragraph  A.5.(c)(i)(E)
hereof) by the  Corporation  after the date of  issuance  of Series D  Preferred
Stock, except:

                    (A) Common Stock issued pursuant to a transaction  described
in Paragraph A.5.(c)(iii) hereof;

                    (B) Common  Stock or options to purchase  such Common  Stock
issued  to  officers,   employees  or  directors  of,  or  consultants  to,  the
Corporation,  pursuant to any  agreement,  plan or  arrangement  approved by the
Board of  Directors  of the  Corporation;  provided,  however,  that the maximum
                                           --------   -------
number of shares of Common  Stock  heretofore  or  hereafter  issued or issuable
pursuant  to all such  agreements,  plans and

                                      -6-
<PAGE>

arrangements  shall not exceed an aggregate (as  constituted on the date hereof)
of Two Million  Three  Hundred Two Thousand  (2,302,000)  shares of Common Stock
("Permitted Options"); and

                    (C) Common  Stock  issued or  issuable  upon  conversion  of
shares of Series D Preferred Stock.

               (iii) In the  event the  Corporation  at any time or from time to
time after the date of issuance of Series D Preferred  Stock fixes a record date
for the  effectuation  of a split or  subdivision of the  outstanding  shares of
Common Stock or the  determination of holders of shares of Common Stock entitled
to receive a dividend  or other  distribution  payable in  additional  shares of
Common Stock or other  securities or rights  convertible  into, or entitling the
holder thereof to receive  directly or indirectly,  additional  shares of Common
Stock (hereinafter referred to as "Common Stock Equivalents") without payment of
any  consideration  by such holder for the additional  shares of Common Stock or
Common  Stock  Equivalents  (including  the  additional  shares of Common  Stock
issuable upon conversion or exercise thereof),  then, as of such record date (or
the date of such dividend,  distribution, split or subdivision if no record date
is  fixed),  the  Conversion  Price of the  Series D  Preferred  Stock  shall be
appropriately decreased so that the number of shares of Common Stock issuable on
conversion  of each share of Series D  Preferred  Stock  shall be  increased  in
proportion  to such  increase in the  aggregate  number of shares  issuable with
respect to Common Stock  Equivalents,  with the number of shares  issuable  with
respect to Common Stock  Equivalents  determined from time to time in the manner
provided for deemed issuances in Subparagraph A.5.(c)(i)(E) hereof.

               (iv) If the number of shares of Common Stock  outstanding  at any
time after the date of issuance of Series D Preferred  Stock is  decreased  by a
combination  of the  outstanding  shares of Common  Stock,  then,  following the
record date of such combination, the Conversion Price for the Series D Preferred
Stock shall be  appropriately  increased  so that the number of shares of Common
Stock issuable on conversion of each share of Series D Preferred  Stock shall be
decreased in  proportion to such  decrease in the  outstanding  shares of Common
Stock.

          (d) OTHER DISTRIBUTIONS.  In the event the Corporation shall declare a
distribution  payable in securities of other persons,  evidences of indebtedness
issued by the Corporation or other persons, assets (excluding cash dividends) or
options or rights not referred to in Paragraph  A.5.(c)(iii)  hereof,  then,  in
each such case for the purpose of this Paragraph A.5.(d),  the holders of shares
of Series D Preferred  Stock shall be entitled to a  proportionate  share of any
such  distribution as though they were holders of the number of shares of Common
Stock into which their shares of Series D Preferred  Stock are convertible as of
the record date fixed for the  determination  of the holders of shares of Common
Stock entitled to receive such distribution.

          (e) RECAPITALIZATION.  If at any time or from time to time there shall
be a  recapitalization  or  reclassification  of  Common  Stock  (other  than  a
subdivision,  combination  or  consolidation,  merger or sale of assets or stock
transaction  provided for in Paragraph A.6. hereof),  provision shall be made so
that each  holder of shares of Series D  Preferred  Stock  shall  thereafter  be
entitled to receive, upon conversion of the Series D Preferred Stock, the number
of  shares  of stock or other  securities  or  property  of the  Corporation  or
otherwise, receivable upon such recapitalization or reclassification by a holder
of the  number of shares of Common  Stock  into  which  such  shares of Series D
Preferred   Stock  could  have  been   converted   immediately   prior  to  such
recapitalization.  In any such case, appropriate adjustment shall be made in the
application  of the provisions of this Paragraph A.5. with respect to the rights
of the holders of shares of Series D Preferred Stock after the  recapitalization
or  reclassification  to the end  that the  provisions  of this  Paragraph  A.5.
(including  adjustments of the Conversion Price then in effect and the number of
shares  purchasable  upon  conversion of the Series D Preferred  Stock) shall be
applicable after that event as nearly equivalent as may be practicable.

          (f) NO  IMPAIRMENT.  The  Corporation  will not, by  amendment of this
Certificate of Incorporation or through any reorganization,  recapitalization or
any other voluntary action, avoid or seek to avoid the observance or performance
of any of the terms to be observed or performed  hereunder  by the  Corporation,
but will at all  times  in good  faith  assist  in the  carrying  out of all the
provisions of this Paragraph A.5. and in the taking

                                      -7-
<PAGE>

of all such action as may be  necessary or  appropriate  in order to protect the
conversion  rights of the holders of shares of Series D Preferred  Stock against
impairment.

          (g) NO FRACTIONAL  SHARES.  No fractional  shares shall be issued upon
conversion of the Series D Preferred  Stock,  and the number of shares of Common
Stock to be issued shall be rounded upward to the nearest whole share, and there
shall be no  payment to a holder of shares of Series D  Preferred  Stock for any
such rounded fractional share. Whether or not fractional shares result from such
conversion  shall be  determined  on the basis of the total  number of shares of
Series D Preferred  Stock the holder is at the time converting into Common Stock
and  the  number  of  shares  of  Common  Stock  issuable  upon  such  aggregate
conversion.

          (h)  CERTIFICATE  AS TO  ADJUSTMENTS.  Upon  the  occurrence  of  each
adjustment or  readjustment  of the  Conversion  Price of the Series D Preferred
Stock pursuant to this Paragraph A.5., the  Corporation,  at its expense,  shall
promptly  compute such  adjustment or  readjustment in accordance with the terms
hereof and  prepare  and  furnish to each holder of shares of Series D Preferred
Stock a certificate setting forth such adjustment or readjustment and showing in
detail the facts upon which such adjustment or readjustment is based,  certified
by the  Corporation's  President or Chief  Financial  Officer.  The  Corporation
shall,  upon the written request at any time of any holder of shares of Series D
Preferred  Stock,  furnish  or  cause  to be  furnished  to such  holder  a like
certificate  setting  forth  (i)  such  adjustment  and  readjustment,  (ii) the
Conversion Price at the time in effect, and (iii) the number of shares of Common
Stock and the  amount,  if any,  of other  property  which at the time  would be
received upon the conversion of a share of Series D Preferred Stock.

          (i)  NOTICES  OF  RECORD  DATE.  In the  event  of any  taking  by the
Corporation  of a record  of the  holders  of any  class of  securities  for the
purpose of  determining  the  holders  thereof  who are  entitled to receive any
dividend  (other  than a cash  dividend)  or other  distribution,  any  right to
subscribe for, purchase or otherwise acquire any shares of stock of any class or
any other securities or property, or to receive any other right, the Corporation
shall mail to each holder of shares of Series D Preferred Stock, at least twenty
(20) calendar days prior to the date specified  therein, a notice specifying the
date on which any such record is to be taken for the  purpose of such  dividend,
distribution  or  right,   and  the  amount  and  character  of  such  dividend,
distribution or right.

     (j)  RESERVATION  OF  STOCK  ISSUABLE  UPON  CONVERSION,   DIVIDENDS.   The
Corporation  shall at all  times  take  appropriate  steps to  reserve  and keep
available out of its authorized but unissued shares of Common Stock,  solely for
the purpose of (i) effecting the  conversion of the shares of Series D Preferred
Stock,  such number of its shares of Common  Stock as shall from time to time be
sufficient  to  effect  the  conversion  of all  outstanding  shares of Series D
Preferred  Stock, and (ii) the payment of dividends as contemplated in Paragraph
A.3.(a).  If at any time the number of authorized but unissued  shares of Common
Stock shall not be sufficient to effect the  conversion of all then  outstanding
shares of Series D Preferred Stock or the payment of dividends, then in addition
to such other  remedies  as shall be  available  to the holder of such shares of
Series D Preferred  Stock,  the Corporation  will take such corporate  action as
may, in the opinion of its counsel,  be necessary to increase its authorized but
unissued  shares of Common Stock to such number of shares as shall be sufficient
for such purposes.

          (k) NOTICES.  Any notice  required by the provisions of this Paragraph
A.5. to be given to the  holders of shares of Series D Preferred  Stock shall be
deemed given when  received if delivered  via courier or sent by  facsimile,  by
telex, or by United States mail,  postage prepaid,  and addressed to each holder
of record at his, her or its address appearing on the books of the Corporation.

          (l) MANDATORY CONVERSION.

               (i) All or a portion  of the shares of Series D  Preferred  Stock
shall,  at the  option  of the  Corporation  (as  determined  by  the  Board  of
Directors),   automatically  be  converted  into  fully  paid,   registered  and
non-assessable  shares of Common Stock in accordance  with Paragraph  A.5.(a)(i)
above, if at any time after the date the first share of Series D Preferred Stock
is issued, the following two conditions are met:


                                      -8-
<PAGE>


                    (A) the Closing  Common  Stock  Market  Price (as defined in
Paragraph B.(d) hereof) for forty (40) consecutive  trading days is at least two
hundred percent (200%) of the Conversion Price then in effect; and

                    (B) an effective  shelf  registration  (in  accordance  with
Section 5(b) of the Stockholders and Registration Rights Agreement) is in effect
for the shares of Common  Stock to be issued  upon  conversion  of the shares of
Series D Preferred Stock.

               (ii) If the Corporation has elected to convert Series D Preferred
Stock into Common Stock pursuant to Paragraph  A.5.(l)(i) above, the Corporation
will  provide  written  notice  of  mandatory  conversion  of shares of Series D
Preferred  Stock to each  holder of record of Series D  Preferred  Stock no less
than thirty (30) nor more than sixty (60)  calendar days prior to the date fixed
for  conversion  by first class mail,  postage  prepaid,  to each holder at such
holder's  address as it appears on the stock  register of the  Corporation.  The
Corporation's  obligation  to  deliver  shares of Common  Stock  shall be deemed
fulfilled if, on the mandatory  conversion  date, the Corporation  shall deposit
with a bank or trust  company in New York,  New York having  capital of at least
One  Hundred  Million  Dollars  ($100,000,000),  such number of shares of Common
Stock as are required to be delivered by the Corporation  upon the conversion of
the shares of Series D Preferred  Stock so called for  conversion.  Provided the
Corporation  has fulfilled its  obligation to deposit  shares as provided in the
foregoing  sentence,  effective on the  mandatory  conversion  date fixed by the
Corporation  and  notified  to the  holders of Series D  Preferred  Stock,  each
outstanding  share of Series D Preferred  Stock shall be converted  into a fully
paid,  registered,  and  non-assessable  share of Common Stock at the Conversion
Price then in effect,  automatically  and  without any action on the part of any
holder  of shares of Series D  Preferred  Stock,  and each such  share of Common
Stock shall be deemed outstanding from and after the mandatory conversion date.

     6. OPTIONAL REDEMPTION.

          (a) If at any time after the date of  original  issuance of the shares
of Series D Preferred  Stock less than five percent (5%) of the shares of Series
D Preferred Stock originally  issued are outstanding,  the Corporation  shall be
entitled,  at the  Corporation's  option,  to  redeem  the  shares  of  Series D
Preferred  Stock then  outstanding  for an amount equal to one hundred (100%) of
the original  issue price per share plus an amount  equal in full to  cumulative
accrued  dividends  and Default  Dividends  (whether or not earned or  declared)
accrued and unpaid thereon.

          (b) In the event that on and after the third (3rd)  anniversary of the
date of the  original  issuance of the Series D Preferred  Stock and  continuing
until the fifth  (5th)  anniversary  thereof a Change  in  Control  occurs,  the
Corporation  shall be  entitled,  at its option,  to redeem all of the shares of
Series D Preferred  Stock then  outstanding  for an amount  equal to one hundred
twenty percent  (120%) per share of the  liquidation  preference  plus an amount
equal in full to cumulative  accrued dividends and Default Dividends (whether or
not earned or  declared)  accrued and unpaid  thereon  from the date of original
issuance of the Series D Preferred Stock until the date of redemption.

          (c) If at any time after the fifth  (5th)  anniversary  of the date of
the  original  issuance  of the  Series D  Preferred  Stock a Change in  Control
occurs,  the Corporation shall be entitled,  at its option, to redeem all of the
shares of Series D Preferred  Stock then  outstanding for an amount equal to one
hundred  percent (100%) per share of the  liquidation  preference plus an amount
equal in full to  cumulative  dividends  and Default  Dividends  (whether or not
earned  or  declared)  accrued  and  unpaid  thereon  from the date of  original
issuance of the Series D Preferred Stock until the date of redemption.

          (d) If the  Corporation  elects to  redeem  Series D  Preferred  Stock
pursuant to this  Paragraph  6A.(a),  (b) or (c), the  Corporation  will provide
written notice of such optional redemption of shares of Series D Preferred Stock
to each holder of record of Series D  Preferred  Stock not less than thirty (30)
calendar  days  prior to the date  fixed for  redemption  by first  class  mail,
postage  prepaid,  to each holder and such holder's address as it appears on the
stock register of the Corporation.


                                      -9-
<PAGE>

     7. STATUS OF CONVERTED STOCK. In the event any shares of Series D Preferred
Stock are converted to Common Stock  pursuant to Paragraph A.5.  hereof,  or are
redeemed by the  Corporation  pursuant to Paragraph A.6.  hereof,  the shares so
converted or so redeemed shall be canceled, retired and eliminated and shall not
be  reissued  by  the  Corporation.  The  Certificate  of  Incorporation  of the
Corporation shall be appropriately amended to effect the corresponding reduction
in the Corporation's authorized capital stock.

     8. VOTING RIGHTS.

          (a) GENERAL. The holders of Series D Preferred Stock shall be entitled
to vote  together with the holders of Common Stock on all matters to be voted on
by the Corporation on an as-converted basis.

          (b) CLASS VOTING RIGHTS.

               (i)  Except as  otherwise  provided  below,  a vote of at least a
majority of the shares of the Series D Preferred Stock then outstanding shall be
sufficient to take any action requiring the vote of the Series D Preferred Stock
as a separate  class.  At any meeting  where the Series D Preferred  Stock shall
have the right to vote as a separate class, the presence, in person or by proxy,
of a majority of the then  outstanding  shares of Series D Preferred Stock shall
constitute a quorum of such class.

               (ii) So long as any Series D Preferred Stock is outstanding,  the
Corporation  shall not,  without the affirmative vote of the holders of at least
sixty-six and two-thirds percent (66 2/3%) of all outstanding shares of Series D
Preferred  Stock  voting  separately  as a class,  given in  person or by proxy,
either in writing  or by  resolution  adopted  at an annual or  special  meeting
called  for this  purpose  (A)  amend,  alter or  repeal  any  provision  of the
Certificate of Incorporation or By-laws of the Corporation,  each as amended, so
as to affect,  in any manner adverse to the holders of Series D Preferred Stock,
the relative rights, preferences, qualifications, limitations or restrictions of
the Series D Preferred Stock; (B) create, authorize, designate or reclassify any
authorized stock of the Corporation  into, or increase the authorized amount of,
or issue any capital  stock that ranks senior to or pari passu with the Series D
                                                    ---- -----
Preferred Stock, or any Junior Securities,  whether voluntary or involuntary, or
any security  convertible into such a class or series,  which are required to be
redeemed  by the  Corporation  at any time that any shares of Series D Preferred
Stock are  outstanding;  (C) during the first twelve (12) months  after  Closing
issue Common  Stock or  securities  convertible  into Common Stock at a price or
conversion  price (except  options under the Option Plans) below the  Conversion
Price  then in  effect;  or (D) take any other  action on which the  holders  of
Series D Preferred Stock shall be entitled by law to vote separately as a class.

               (iii) The  Corporation  shall not,  without the  express  written
approval  of the  holders  of record  of a  majority  of the  shares of Series D
Preferred Stock then outstanding take any of the following actions:

                    (A) DIVIDENDS.  The Corporation shall not declare or pay any
dividend or distribution on any shares of capital stock of the Corporation other
than dividends on Series D Preferred Stock.

                    (B)  INDEBTEDNESS.  The Corporation and its subsidiary shall
not (x)  incur  any  indebtedness  for  borrowed  money  or  guarantee  any such
indebtedness of another person, issue or sell any debt securities or warrants or
other rights to acquire any debt  securities of the  Corporation,  guarantee any
debt securities of another person, enter into any "keep well" or other agreement
to maintain any financial  statement  condition of another  person or enter into
any arrangement having the economic effect of any of the foregoing,  except that
the  Corporation  may incur  such  indebtedness  in any amount not to exceed Ten
Million Dollars  ($10,000,000) in the aggregate outstanding at any time only for
the  Corporation's  working  capital  requirements  in the  ordinary  course  of
business ("Working Capital Loans");  or (y) make any loans,  advances of capital
contributions  to, or  investments  in,  any  other  person,  other  than to the
Corporation or its subsidiaries.

                                      -10-
<PAGE>

                    (C)  DISPOSITIONS.  The Corporation  shall not enter into or
effect  a  recapitalization,   corporate  reorganization   (including,   without
limitation,  any  distribution of assets to a subsidiary of the  Corporation) or
liquidation,  sell,  assign,  lease or otherwise  dispose  (including  by way of
mortgage, license, encumbrance or any lien) of any assets or securities,  except
for (i)  transactions  in the  ordinary  course of  business or (ii) any pledge,
assignment,  encumbrance,  lien or other  disposition of working  capital assets
(accounts receivable and inventory) directly related to the Working Capital Loan
(as defined in Section 2(b)(ii) above), or effectuate any split,  subdivision or
combination  of any Equity  Securities,  or enter into a  material  contract  or
release or relinquish any material contract rights not in the ordinary course of
business, or make any amendments, or modifications thereto.  Notwithstanding the
foregoing,  the  Corporation  shall not,  at any time,  sell,  assign,  lease or
otherwise dispose (including by way of pledge, mortgage, license, encumbrance or
any lien) of any license,  patent or Intellectual  Property of the  Corporation,
except in the ordinary course of business,  without the express written approval
of the  holders of a majority  of the  shares of Series D  Preferred  Stock then
outstanding. For purposes of the foregoing sentence, ordinary course of business
shall  include,  without  limitation,  (a)  licenses  for  purposes of research,
development,   manufacturing,   marketing   and/or   distribution  and  (b)  the
abandonment of any Intellectual Property which the Corporation  determines is of
insignificant benefit to the Corporation and which could not, individually or in
the aggregate, have a Material Adverse Effect on the Corporation.

                    (D) RESEARCH AND DEVELOPMENT  EXPENDITURES.  The Corporation
shall not make research and development  expenditures in excess of Seven Million
Dollars ($7,000,000) in any one (1) continuous twelve (12) month period,  unless
the Corporation has reported positive net income  (calculated in accordance with
generally accepted accounting principles  consistently applied,  reported on all
necessary  and  appropriate  filings of SEC  Documents  and only  excluding  any
extraordinary  or unusual gains) for four (4) consecutive  quarters  immediately
prior to such twelve (12) month period.

                    (E)  ACQUISITIONS.   The  Corporation  shall  not  merge  or
consolidate  with,  purchase,  lease or otherwise make any acquisition of all or
substantially  all of the assets,  properties  or  securities  of, any person or
entity in a transaction or series of related transactions with any calendar year
period in excess of Ten Million Dollars ($10,000,000).

                    (F) PROTECTIVE  AGREEMENTS.  The Corporation  shall not: (i)
enter into any non-disclosure  agreement,  that is not substantially in the form
utilized by the  Corporation  as of the effective  date of this  Certificate  of
Designation,  with each new employee  hired after the date of Closing;  and (ii)
enter into any non-competition  agreement, that is not substantially in the form
utilized  by the  Corporation,  with each new  officer  hired  after the date of
Closing.  The Corporation  shall not terminate,  amend or modify in any material
respect any agreement relating to matters of non-disclosure or non-competition.

                    (G) BENEFIT PLANS. The Corporation  shall not adopt or amend
in any  material  respect any  collective  bargaining  agreement or any Employee
Benefit Plan of the Corporation which,  individually or in the aggregate,  could
reasonably by expected to have a Material Adverse Effect.

          (c) BOARD OF  DIRECTORS.  The Board of  Directors  of the  Corporation
shall consist of not less than five (5) and not more than nine (9) directors. At
each annual meeting of the stockholders of the Corporation,  and at each special
meeting  of the  stockholders  of the  Corporation  called  for the  purpose  of
electing directors of the Corporation,  and at any time at which stockholders of
the  Corporation  shall  have the right to, or  shall,  vote for or  consent  in
writing to the election of directors of the Corporation,  then, and in each such
event, until the occurrence of an Event of Default, (i) the holders of record of
shares of Series D Preferred  Stock voting together as a separate class shall be
entitled,  but not obligated,  to elect one (1) director, who shall be nominated
by the holders of record of a majority of the shares of Series D Preferred Stock
then outstanding (the "Series D Preferred Stock Director"), and (ii) the holders
of record of shares of Common Stock shall elect the remaining directors, up to a
maximum of eight (8),  all of whom shall be  nominated by the Board of Directors
of the Corporation (collectively,  the "Common Directors").  At any such meeting
called for the purpose of electing directors, the presence in person or by proxy
of (i) the  holders of record of a majority  of the shares of Series D Preferred
Stock then  outstanding,  in the case of the  election of the Series D Preferred
Stock  Director  and (ii) the  holders of record of a majority  of the shares of
each of the Common  Stock,  in the case of the  election  of a Common

                                      -11-
<PAGE>

Director,  shall constitute a quorum for the election of directors to be elected
by such  holders.  A vacancy in any  directorship  entitled to be elected by the
holders  of record of shares of  Series D  Preferred  Stock  (including  without
limitation,  a vacancy resulting from the decision during an earlier election by
the holders of the Series D Preferred  Stock not to fill the  directorship to be
held by the Series D Preferred  Stock  Director) shall be filled only by vote or
written consent of the holders of record of shares of Series D Preferred  Stock,
in the manner set forth  herein.  A vacancy in any  directorship  elected by the
holders  of record  of Common  Stock  shall be  filled  only by vote or  written
consent of the  holders of record of shares of Common  Stock,  in the manner set
forth  herein.  Each Common  Director who shall have been elected as provided in
this Paragraph A.8.(c) may be removed during his or her term of office,  whether
with or without cause, only by the holders of record of a majority of the shares
of Common Stock then outstanding, and each Series D Preferred Stock Director who
shall have been  elected as  provided in this  Paragraph  A.8.(c) may be removed
during his or her term of office,  whether with or without cause, by the holders
of  record  of a  majority  of the  shares  of  Series D  Preferred  Stock  then
outstanding.  Each Common  Director  and the Series D Preferred  Stock  Director
shall be entitled to one (1) vote on all matters which directors are entitled to
vote on. The holders of record of a majority of the shares of Series D Preferred
Stock then  outstanding  shall have the right to call  meetings  of the Board of
Directors and management of the Corporation, upon no less than five (5) calendar
days' prior  written  notice;  provided,  that such  meetings are called no more
                               --------
frequently than once per fiscal quarter;  and, provided,  further, so long as no
Event of Default has occurred or is continuing,  a meeting may be called only if
the Board of Directors has not held a board meeting or scheduled a board meeting
for the calendar  quarter in which such holders of Series D Preferred Stock seek
to call a meeting.  During  such time as holders of record of a majority  of the
Series D Preferred  Stock then  outstanding  are  entitled to elect the Series D
Preferred  Stock Director to the Board of Directors,  such holders shall also be
entitled  to  have  such  Series  D  Preferred   Stock  Director  serve  on  the
compensation  committee  of the Board of  Directors  and any  special  committee
created by the Board of Directors not in the ordinary course of business and the
Corporation  shall  cause  such  Series  D  Preferred  Stock  Director  to be so
appointed;  provided,  however,  that if such Series D Preferred  Stock Director
            --------   -------
would not be considered "independent" or "disinterested" (i) for purposes of any
applicable rule of NASDAQ or (ii) for purposes of any special  committee  formed
in  connection  with any  transaction  or potential  transaction  involving  the
Corporation  and Investor or any Purchaser,  then such Series D Preferred  Stock
Director shall not be eligible to be appointed to such committee.

     9. LACK OF PUBLIC MARKET. If the Common Stock of the Corporation  ceases to
be listed or authorized to be quoted on any national  securities exchange or the
public market for the Common Stock of the Corporation otherwise ceases to exist,
the Corporation  shall engage an investment bank,  reasonably  acceptable to the
Corporation  and the holders of record of a majority of the shares of the Series
D Preferred Stock, to determine the fair market value price of the Common Stock,
from time to time, in connection with Paragraphs A.3., A.5. and A.6.

B.   Definitions.  As used herein,  the following terms shall have the following
     -----------
     definitions:

               (a)  "Accumulated  Dividends"  means with respect to any share of
Series D Preferred  Stock,  the dividends that have accrued on such shares as of
such specific date for Dividend Periods ending on or prior to such date and that
have not  previously  been  paid in cash,  including  Additional  Dividends  and
Default Dividends.

               (b) "Additional  Dividends" has the meaning given to such term in
Paragraph A.(3)(e).

               (c)  "Additional  Stock" has the meaning  set forth in  Paragraph
A.(5)(c)(ii).

               (d) "Closing  Common  Stock  Market  Price" for any day means the
last sale price  regular  way, or, in case no such sale takes place on such day,
the average of the closing bid and asked  prices  regular way, in either case as
reported  on  American  Stock  Exchange,  NASDAQ,  NYSE  or any  other  national
securities market.

                                      -12-
<PAGE>

               (e)  "Common  Stock  Equivalents"  has the  meaning  set forth in
Paragraph A.(5)(c)(iii) hereof.

               (f)  "Conversion  Price" has the meaning  set forth in  Paragraph
A.(5)(a) hereof.

               (g) "Convertible  Securities" means any indebtedness or shares of
stock convertible into or exchangeable for Common Stock.

               (h)  "Dividend  Declaration  Date" means the last  trading day on
NASDAQ  immediately  prior to June 30 and  December 31 of each year in which any
shares of the Series D Preferred Stock are outstanding.

               (i) "Dividend Payment Dates" means July 31 and January 31 of each
year (or, if such day is not a business day, the next  succeeding  day that is a
business  day);  provided,  however,  that with  respect to July 31,  1999,  the
                 --------   -------
Dividend  Declaration  Date shall be the later to occur of (i) July 31, 1999, or
(ii) the date on which the Corporation's  registration statement with respect to
the Common Stock with which dividends are then to be paid is declared  effective
by the Securities and Exchange Commission.

               (j)  "Dividend  Period"  means the Initial  Dividend  Period and,
thereafter, each Semi-Annual Dividend Period.

               (k)  "Effective  Price" of shares of  Additional  Stock means the
quotient  determined  by  dividing  (i)  the  total  number  of such  shares  of
Additional  Stock issued or sold,  or deemed to have been issued or sold, by the
Corporation  under  Paragraph  A.(5)(c)  hereof,  into  (ii)  the  consideration
received by the Corporation under Paragraph  A.(5)(c) hereof for the issuance of
such shares of Additional Stock.

               (l)  "Initial   Dividend   Period"  means  the  dividend   period
commencing on the date of issuance of the Series D Preferred Stock and ending on
the first Dividend Payment Date to occur thereafter.

               (m) "Investor" means OCM Principal Opportunities Fund, L.P.

               (n)  "Intellectual  Property"  has the  meaning  set forth in the
Stock Purchase Agreement.

               (o) "Junior  Payment Date" has the meaning set forth in Paragraph
A.(3)(i) hereof.

               (p) "Junior  Securities"  has the meaning set forth in  Paragraph
A.(2) hereof.

               (q) "Material  Adverse  Effect" shall mean (i) any adverse change
in  the  condition   (financial  or  otherwise),   assets  (including,   without
limitation, patents and licenses to patents), liabilities,  business, results of
operations  or  prospects  of  the  Company  or  its  Subsidiary,  which  change
individually or in the aggregate,  is material to the Company or its Subsidiary,
or (ii) any event, matter,  condition or effect which impairs the ability of the
Company  or  its  Subsidiary  to  perform  on a  timely  basis  its  obligations
hereunder.  Materiality  under clauses (i) or (ii) hereof shall be determined in
good  faith by the  holders  of record of a  majority  of the shares of Series D
Preferred Stock.

               (r) "NASDAQ" shall have the meaning set forth in Paragraph A.3(a)
hereof.

               (s) "NYSE" shall mean the New York Stock Exchange.

               (t) "Option" means rights,  options or warrants to subscribe for,
purchase or otherwise acquire Common Stock or Convertible Securities.

                                      -13-
<PAGE>

               (u)  "Purchaser"  and  "Purchasers"  shall  mean  those  persons,
individually  and  collectively,  other than  Investor the  Corporation  who are
parties to the Stock Purchase Agreement, as identified on Exhibit D to the Stock
Purchase Agreement.

               (v)  "Permitted  Options"  has the meaning set forth in Paragraph
A.(5)(c)(ii)(B) hereof.

               (w) "Semi-Annual  Dividend Periods" means the semi-annual periods
(1)  commencing on each January 1 and ending on each June 30 and (2)  commencing
on July 1 and ending on each December 31.

               (x)  "Stockholders  and Registration  Rights Agreement" means the
Stockholders  and  Registration  Rights  Agreement  dated as of March __,  1999,
between the  Corporation,  the Investor and the Purchasers  named  therein,  the
Schedules and Exhibits  thereto,  and any certificate or other document required
thereby, as the same may be amended from time to time.

               (y) "Stock Purchase Agreement" means the Stock Purchase Agreement
dated as of March __, 1999, between the Corporation, Investor and the Purchasers
named therein,  the Schedules and Exhibits thereto, and any certificate or other
document required thereby, as the same may be amended from time to time.

          IN WITNESS WHEREOF,  the undersigned has caused this Certificate to be
signed on the _____ day of _____, 1999.




                                          ------------------------------
                                          OFFICER












                                     - 18 -
<PAGE>


                                    EXHIBIT A

      Example of Application of Formula for Adjustment of Conversion Price.

          If,  twelve (12) months  after the  original  issuance of the Series D
Preferred Stock,  9,000,000 shares of Common Stock were then outstanding and the
Company were to issue 100,000 shares of Common Stock (the Additional  Stock) for
$10.00  per share  (and thus,  less than the $11  Conversion  Price for Series D
Preferred  Stock then in  effect),  the  Conversion  Price  would be adjusted as
follows:


                               [(A+B)] / [(C +D)]

[(9,000,000 x $11) + (100,000 x $10)] /  [(9,000,000) +(100,000)]

         [(99,000,000)+($1,000,000 )] /  [(9,100,000)]

                      [(100,000,000)] /  [(9,100,000)]

                                     = $10.99






                        COLLAGENEX PHARMACEUTICALS, INC.

                                 1996 STOCK PLAN



     1. PURPOSES OF THE PLAN. The purposes of this Stock Plan are to attract and
retain the best available personnel for positions of substantial responsibility,
to provide additional incentive to Employees,  non-Employee members of the Board
and Consultants of the Company and its  Subsidiaries  and to promote the success
of the Company's business. Options granted under the Plan may be incentive stock
options  (as  defined  under  Section  422 of the Code) or  non-statutory  stock
options,  as determined by the  Administrator  at the time of grant of an option
and subject to the applicable provisions of Section 422 of the Code, as amended,
and the regulations  promulgated  thereunder.  Stock purchase rights may also be
granted under the Plan.

     2. CERTAIN  DEFINITIONS.  As used herein,  the following  definitions shall
apply:

     (a)  "Administrator"  means  the Board or any of its  Committees  appointed
pursuant to Section 4 of the Plan.

     (b) "Board" means the Board of Directors of the Company.

     (c) "Code" means the Internal Revenue Code of 1986, as amended.

     (d) "Committee" means the Committee  appointed by the Board of Directors in
accordance with paragraph (a) of Section 4 of the Plan.

     (e) "Common Stock" means the Common Stock of the Company.

     (f)  "Company"   means   CollaGenex   Pharmaceuticals,   Inc.,  a  Delaware
corporation.

     (g) "Consultant" means any person,  including an advisor, who is engaged by
the Company or any Parent or  subsidiary to render  services and is  compensated
for such services,  and any director of the Company whether compensated for such
services or not.

     (h)   "Continuous   Status  as  an  Employee"  means  the  absence  of  any
interruption or termination of the employment relationship by the Company or any
Subsidiary. Continuous Status as an Employee shall not be considered interrupted
in the case of: (i) sick leave;  (ii) military  leave;  (iii) any other leave of
absence  approved by the Board,  provided that such leave is for a period of not
more than ninety (90) days,  unless  reemployment  upon the  expiration  of such
leave is  guaranteed  by  contract  or  statute,  or unless  provided  otherwise
pursuant to Company policy adopted from time to time; or (iv) transfers  between
locations  of the  Company or  between  the  Company,  its  Subsidiaries  or its
successor.


<PAGE>


     (i) "Employee" means any person, including officers and directors, employed
by the  Company or any Parent or  Subsidiary  of the  Company.  The payment of a
director's fee by the Company shall not be sufficient to constitute "employment"
by the Company.

     (j) "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     (k) "Fair Market  Value" means,  as of any date,  the value of Common Stock
determined as follows:

          (i) If the Common Stock is listed on any established stock exchange or
     a national market system including  without  limitation the National Market
     System of the National  Association of Securities  Dealers,  Inc. Automated
     Quotation  ("Nasdaq")  System,  its Fair Market  Value shall be the closing
     sales price for such stock (or the closing bid, if no sales were  reported)
     as quoted on such system or exchange for the last market  trading day prior
     to the time of determination as reported in the Wall Street Journal or such
     other source as the Administrator deems reliable or;

          (ii) If the Common  Stock is quoted on Nasdaq (but not on the National
     Market  System  thereof) or  regularly  quoted by a  recognized  securities
     dealer but selling prices are not reported,  its Fair Market Value shall be
     the mean between the high and low asked prices for the Common Stock or;

          (iii) In the absence of an  established  market for the Common  Stock,
     the Fair Market  Value  thereof  shall be  determined  in good faith by the
     Administrator.

     (l)  "Incentive  Stock  Option"  means an Option  intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code.

     (m) "Nonstatutory  Stock Option" means an Option not intended to qualify as
an Incentive Stock Option.

     (n) "Option" means a stock option granted pursuant to the Plan.

     (o) "Optioned Stock" means the Common Stock subject to an Option.

     (p) "Optionee" means an Employee or Consultant who receives an Option.

     (q)  "Parent"  means  a  "parent  corporation",  whether  now or  hereafter
existing, as defined in Section 424(e) of the Code.

     (r) "Plan" means this 1996 Stock Plan.

     (s) "Restricted  Stock" means shares of Common Stock acquired pursuant to a
grant of stock purchase rights under Section 11 below.


                                      -2-
<PAGE>


     (t) "Share"  means a share of the Common  Stock,  as adjusted in accordance
with Section 13 of the Plan.

     (u) "Subsidiary" means a "subsidiary corporation", whether now or hereafter
existing, as defined in Section 424(f) of the Code.

     3. STOCK  SUBJECT TO THE PLAN.  Subject to the  provisions of Section 13 of
the Plan, the maximum  aggregate number of shares which may be optioned and sold
under  the Plan is  750,000  shares  of  Common  Stock,  such  number  of shares
determined  on  a  post-reverse   stock  split   recapitalization   basis,  such
recapitalization  to be completed upon  consummation  of the Company's  proposed
initial  public  offering of Common  Stock.  The shares may be  authorized,  but
unissued, or reacquired Common Stock.

          If an  option  should expire or  become  unexercisable  for any reason
without having been exercised in full, the unpurchased Shares which were subject
thereto shall, unless the Plan shall have been terminated,  become available for
future grant under the Plan.

     4. ADMINISTRATION OF THE PLAN.

     (a) PROCEDURE.

          (i)  Administration  With  Respect to  Directors  and  officers.  With
     respect to grants of Options or stock purchase  rights to Employees who are
     also officers or directors of the Company,  the Plan shall be  administered
     by (A) the Board if the Board may  administer  the Plan in compliance  with
     Rule 16b-3  promulgated  under the  Exchange Act or any  successor  thereto
     ("Rule  16b-3") with respect to a plan intended to qualify  thereunder as a
     discretionary  plan,  or  (B)  a  Committee  designated  by  the  Board  to
     administer the Plan,  which Committee shall be constituted in such a manner
     as to permit  the Plan to comply  with Rule  16b-3  with  respect to a plan
     intended to qualify  thereunder as a  discretionary  plan.  Once appointed,
     such Committee  shall  continue to serve in its  designated  capacity until
     otherwise  directed by the Board.  From time to time the Board may increase
     the size of the Committee and appoint  additional  members thereof,  remove
     members  (with or without  cause) and appoint  new members in  substitution
     therefor,  fill vacancies,  however  caused,  and remove all members of the
     Committee and  thereafter  directly  administer the Plan, all to the extent
     permitted  by  Rule  16b-3  with  respect  to a plan  intended  to  qualify
     thereunder as a discretionary plan.

          (ii) Multiple  Administrative  Bodies. If permitted by Rule 16b-3, the
     Plan may be  administered  by different  bodies with respect to  directors,
     non-director officers and Employees who are neither directors nor officers.

          (iii)  Administration With Respect to Consultants and Other Employees.
     With respect to grants of Options or stock purchase rights to Employees who
     are neither  directors nor officers of the Company or to  Consultants,  the
     Plan shall be  administered  by (A) the Board,  if the Board may administer
     the Plan in compliance  with Rule 16b-3,  or (B) a Committee  designated by


                                      -3-
<PAGE>


     the Board,  which  Committee  shall be  constituted  in such a manner as to
     satisfy the legal requirements  relating to the administration of incentive
     stock  option  plans,  if any, of  Delaware  corporate  law and  applicable
     securities laws and of the Code (the  "Applicable  Laws").  Once appointed,
     such Committee  shall  continue to serve in its  designated  capacity until
     otherwise  directed by the Board.  From time to time the Board may increase
     the size of the Committee and appoint  additional  members thereof,  remove
     members  (with or without  cause) and appoint  new members in  substitution
     therefor,  fill vacancies,  however  caused,  and remove all members of the
     Committee and  thereafter  directly  administer the Plan, all to the extent
     permitted by the Applicable Laws.

     (b) POWERS OF THE ADMINISTRATOR.  Subject to the provisions of the Plan and
in the case of a Committee,  the specific duties  delegated by the Board to such
Committee, the Administrator shall have the authority, in its discretion:

          (i) to  determine  the Fair  Market  Value  of the  Common  Stock,  in
     accordance with Section 2(k) of the Plan;

          (ii) to select the officers, Consultants and Employees to whom Options
     and stock purchase rights may from time to time be granted hereunder;

          (iii) to  determine  whether  and to what  extent  Options  and  stock
     purchase rights or any combination thereof, are granted hereunder;

          (iv) to  determine  the number of shares of Common Stock to be covered
     by each such award granted hereunder;

          (v) to approve forms of agreement for use under the Plan;

          (vi) to determine the terms and conditions,  not inconsistent with the
     terms of the  Plan,  of any award  granted  hereunder  (including,  but not
     limited to, the share price and any  restriction or limitation or waiver of
     forfeiture  restrictions  regarding  any Option or other  award  and/or the
     shares of Common Stock relating thereto, based in each case on such factors
     as the Administrator shall determine, in its sole discretion);

          (vii) to determine whether and under what  circumstances an Option may
     be settled in cash under subsection 9(f) instead of Common Stock;

          (viii)  to   determine   whether,   to  what  extent  and  under  what
     circumstances  Common  Stock and other  amounts  payable with respect to an
     award  under this Plan shall be  deferred  either  automatically  or at the
     election of the  participant  (including  providing for and determining the
     amount,  if any, of any deemed  earnings on any deferred  amount during any
     deferral period);


                                      -4-
<PAGE>


          (ix) to reduce the  exercise  price of any Option to the then  current
     Fair Market Value if the Fair Market  Value of the Common Stock  covered by
     such Option shall have declined since the date the Option was granted; and

          (x) to  determine  the  terms  and  restrictions  applicable  to stock
     purchase rights and the Restricted Stock purchased by exercising such stock
     purchase rights.

     (c) EFFECT OF  COMMITTEE'S  DECISION.  All  decisions,  determinations  and
interpretations of the Administrator shall be final and binding on all Optionees
and any other holders of any Options.

     5. ELIGIBILITY.

     (a) Nonstatutory Stock Options may be granted to Employees and Consultants.
Incentive  Stock  Options  may be granted  only to  Employees.  An  Employee  or
Consultant who has been granted an Option may, if he is otherwise  eligible,  be
granted an additional Option or Options.

     (b) Each Option  shall be  designated  in the written  option  agreement as
either an  Incentive  Stock  Option or a  Nonstatutory  Stock  Option.  However,
notwithstanding such designations,  to the extent that the aggregate Fair Market
Value of the Shares with respect to which Options  designated as Incentive Stock
Options are  exercisable  for the first time by any optionee during any calendar
year  (under  all plans of the  Company  or any  Parent or  Subsidiary)  exceeds
$100,000, such excess Options shall be treated as Nonstatutory Stock Options.

     (c) For purposes of Section  5(b),  Incentive  Stock Options shall be taken
into account in the order in which they were granted,  and the Fair Market Value
of the Shares shall be determined as of the time the Option with respect to such
Shares is granted.

     (d) The Plan shall not confer upon any  Optionee  any right with respect to
continuation  of  employment or consulting  relationship  with the Company,  nor
shall it interfere in any way with his right or the Company's right to terminate
his employment or consulting relationship at any time, with or without cause.

     6. TERM OF PLAN. The Plan shall become  effective upon the earlier to occur
of its adoption by the Board of Directors or its approval by the shareholders of
the Company as described in Section 19 of the Plan. It shall  continue in effect
for a term of ten (10) years unless  sooner  terminated  under Section 15 of the
Plan.


                                      -5-
<PAGE>


     7. TERM OF OPTION.  The term of each Option shall be the term stated in the
Option  Agreement;  provided,  however,  that in the case of an Incentive  Stock
Option,  the term  shall be no more than ten (10)  years  from the date of grant
thereof  or  such  shorter  term as may be  provided  in the  Option  Agreement.
However,  in the case of an Option  granted to an Optionee  who, at the time the
Option is granted,  owns stock  representing  more than ten percent (10%) of the
voting power of all classes of stock of the Company or any Parent or Subsidiary,
the term of the Option shall be five (5) years from the date of grant thereof or
such shorter term as may be provided in the Option Agreement.

     8. OPTION EXERCISE PRICE AND CONSIDERATION.

     (a) The per share  exercise  price for the Shares to be issued  pursuant to
exercise of an Option  shall be such price as is  determined  by the Board,  but
shall be subject to the following:

          (i) In the case of an Incentive Stock Option

               (A) granted to an Employee  who, at the time of the grant of such
               Incentive  Stock Option,  owns stock  representing  more than ten
               percent  (10%) of the voting power of all classes of stock of the
               Company or any Parent or Subsidiary, the per Share exercise price
               shall be no less than 110% of the Fair Market  Value per Share on
               the date of grant.

               (B) granted to any Employee,  the per Share  exercise price shall
               be no less  than 100% of the Fair  Market  Value per Share on the
               date of grant.

          (ii) In the case of a Nonstatutory Stock Option

               (A)  granted  to a person  who,  at the time of the grant of such
               Option,  owns stock  representing  more than ten percent (10%) of
               the voting  power of all  classes of stock of the  Company or any
               Parent or  Subsidiary,  the per Share  exercise price shall be no
               less than 110% of the Fair Market  Value per Share on the date of
               the grant.

               (B) granted to any person,  the per Share exercise price shall be
               no less than 85% of the Fair  Market  Value per Share on the date
               of grant.

     (b) The  consideration to be paid for the Shares to be issued upon exercise
of an  Option,  including  the method of  payment,  shall be  determined  by the
Administrator  (and,  in  the  case  of an  Incentive  Stock  Option,  shall  be
determined  at the time of grant)  and may  consist  entirely  of (1) cash,  (2)
check,  (3)  promissory  note,  (4) other Shares which (x) in the case of Shares
acquired  upon  exercise of an Option either have been owned by the Optionee for
more than six months on the date of surrender or were not acquired,  directly or
indirectly,  from the  Company,  and (y) have a Fair Market Value on the date of
surrender  equal to the aggregate  exercise price of the Shares as to which said
Option shall be exercised, (5) authorization from the Company to retain from the
total number of Shares as to which the Option is exercised that number of Shares
having a Fair Market Value on the date of exercise equal to the exercise price

                                      -6-
<PAGE>


for the total number of Shares as to which the option is exercised, (6) delivery
of a properly executed exercise notice together with irrevocable instructions to
a broker to promptly  deliver to the Company the amount of sale or loan proceeds
required  to  pay  the  exercise   price,   (7)  by  delivering  an  irrevocable
subscription  agreement  for the Shares which  irrevocably  obligates the option
holder to take and pay for the Shares not more than twelve months after the date
of delivery of the subscription agreement,  (8) any combination of the foregoing
methods of payment,  or (9) such other  consideration  and method of payment for
the issuance of Shares to the extent  permitted under Applicable Laws. In making
its  determination as to the type of consideration to accept,  the Administrator
shall consider if acceptance of such consideration may be reasonably expected to
benefit the Company.

     9. EXERCISE OF OPTION.

     (a) PROCEDURE FOR EXERCISE;  RIGHTS AS A  SHAREHOLDER.  Any Option  granted
hereunder  shall be  exercisable  at such  times and under  such  conditions  as
determined by the Administrator,  including performance criteria with respect to
the Company and/or the Optionee,  and as shall be permissible under the terms of
the Plan.

         An Option may not be exercised for a fraction of a Share.

         An Option shall be deemed to be exercised  when written  notice of such
exercise  has been  given to the  Company  in  accordance  with the terms of the
Option by the person  entitled to exercise  the Option and full  payment for the
Shares with  respect to which the Option is exercised  has been  received by the
Company.  Full payment may, as authorized by the  Administrator,  consist of any
consideration  and method of payment  allowable  under Section 8(b) of the Plan.
Until the issuance (as  evidenced by the  appropriate  entry on the books of the
Company or of a duly  authorized  transfer  agent of the  Company)  of the stock
certificate evidencing such Shares, no right to vote or receive dividends or any
other rights as a  shareholder  shall exist with respect to the Optioned  Stock,
notwithstanding the exercise of the Option. The Company shall issue (or cause to
be issued)  such stock  certificate  promptly  upon  exercise of the Option.  No
adjustment  will be made for a dividend or other right for which the record date
is prior to the date the stock  certificate  is issued,  except as  provided  in
Section 11 of the Plan.

         Exercise of an Option in any manner  shall  result in a decrease in the
number of Shares which  thereafter  may be  available,  both for purposes of the
Plan and for sale  under  the  Option,  by the  number of Shares as to which the
Option is exercised.

     (b) TERMINATION OF EMPLOYMENT. In the event of termination of an Optionee's
consulting relationship or Continuous Status as an Employee with the Company (as
the case may be),  such  Optionee may, but only within ninety (90) days (or such
other period of time as is determined by the Board,  with such  determination in
the case of an  Incentive  Stock  Option  being made at the time of grant of the
Option and not  exceeding  ninety (90) days) after the date of such  termination
(but in no event  later than the  expiration  date of the term of such Option as
set forth in the Option  Agreement),  exercise  his  Option to the  extent  that
Optionee was entitled to exercise

                                      -7-
<PAGE>

it at the date of such termination. To the extent that Optionee was not entitled
to exercise the Option at the date of such termination,  or if Optionee does not
exercise such Option to the extent so entitled within the time specified herein,
the Option shall terminate.

     (c) DISABILITY OF OPTIONEE. Notwithstanding the provisions of Section 9(b)
above, in the event of termination of an Optionee's  consulting  relationship or
Continuous  Status  as an  Employee  as a  result  of his  total  and  permanent
disability (as defined in Section 22(e)(3) of the Code),  Optionee may, but only
within  twelve (12) months  from the date of such  termination  (but in no event
later than the  expiration  date of the term of such  Option as set forth in the
Option  Agreement),  exercise  the Option to the extent  otherwise  entitled  to
exercise it at the date of such termination. To the extent that Optionee was not
entitled to exercise the Option at the date of termination,  or if Optionee does
not  exercise  such Option to the extent so entitled  within the time  specified
herein, the Option shall terminate.

     (d) DEATH OF OPTIONEE. In the event of the death of an Optionee, the Option
may be exercised,  at any time within  twelve (12) months  following the date of
death (but in no event later than the expiration date of the term of such Option
as set forth in the Option  Agreement),  by the Optionee's estate or by a person
who  acquired the right to exercise  the Option by bequest or  inheritance,  but
only to the extent the  Optionee was entitled to exercise the Option at the date
of death. To the extent that Optionee was not entitled to exercise the Option at
the date of  termination,  or if Optionee  does not exercise  such Option to the
extent so entitled within the time specified herein, the Option shall terminate.

     (e) RULE 16b-3.  Options granted to persons subject to Section 16(b) of the
Exchange  Act must  comply  with Rule 16b-3 and shall  contain  such  additional
conditions  or  restrictions  as may be required  thereunder  to qualify for the
maximum  exemption  from  Section 16 of the  Exchange  Act with  respect to Plan
transactions.

     (f) BUYOUT  PROVISIONS.  The Administrator may at any time offer to buy out
for a payment in cash or Shares,  an Option  previously  granted,  based on such
terms and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     10.  NON-TRANSFERABILITY  OF OPTIONS.  The Option may not be sold, pledged,
assigned, hypothecated,  transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution and may be exercised,  during the
lifetime of the Optionee, only by the Optionee. The terms of the Option shall be
binding upon the executors, administrators, heirs, successors and assigns of the
Optionee.


                                      -8-
<PAGE>


     11. STOCK PURCHASE RIGHTS.

     (a) RIGHTS TO PURCHASE.  Stock purchase  rights may be issued either alone,
in addition  to, or in tandem with other  awards  granted  under the Plan and/or
cash awards made outside of the Plan. After the Administrator determines that it
will offer stock purchase  rights under the Plan, it shall advise the offeree in
writing  of the  terms,  conditions  and  restrictions  related  to  the  offer,
including  the number of Shares that such person  shall be entitled to purchase,
the price to be paid (which  price shall not be less than 50% of the Fair Market
Value of the Shares as of the date of the offer), and the time within which such
person must accept such offer,  which shall in no event exceed  thirty (30) days
from the date upon which the  Administrator  made the determination to grant the
stock purchase  right.  The offer shall be accepted by execution of a Restricted
Stock purchase agreement in the form determined by the Administrator.

     (b) REPURCHASE OPTION. Unless the Administrator  determines otherwise,  the
Restricted Stock purchase  agreement shall grant the Company a repurchase option
exercisable  upon the voluntary or involuntary  termination  of the  purchaser's
employment with the Company for any reason (including death or Disability).  The
purchase price for Shares repurchased  pursuant to the Restricted Stock purchase
agreement  shall be the original  price paid by the purchaser and may be paid by
cancellation of any indebtedness of the purchaser to the Company. The repurchase
option shall lapse at such rate as the Committee may determine.

     (c) OTHER PROVISIONS. The Restricted Stock purchase agreement shall contain
such other terms,  provisions and conditions not  inconsistent  with the Plan as
may be determined by the Administrator in its sole discretion.  In addition, the
provisions of Restricted  Stock  purchase  agreements  need not be the same with
respect to each purchaser.

     (d) RIGHTS AS A  SHAREHOLDER.  Once the stock  purchase right is exercised,
the purchaser  shall have the rights  equivalent to those of a shareholder,  and
shall be a  shareholder  when his or her purchase is entered upon the records of
the duly  authorized  transfer agent of the Company.  No adjustment will be made
for a dividend or other right for which the record date is prior to the date the
stock purchase right is exercised, except as provided in Section 13 of the Plan.

     12.  STOCK  WITHHOLDING  TO SATISFY  WITHHOLDING  TAX  OBLIGATIONS.  At the
discretion of the Administrator,  Optionees may satisfy withholding  obligations
as  provided  in this  paragraph.  When an  Optionee  incurs  tax  liability  in
connection  with an Option or stock  purchase  right,  which  tax  liability  is
subject to tax  withholding  under  applicable  tax laws,  and the  Optionee  is
obligated to pay the Company an amount required to be withheld under  applicable
tax laws, the Optionee may satisfy the withholding tax obligation by electing to
have the Company withhold


                                      -9-
<PAGE>


from the Shares to be issued upon  exercise  of the Option,  or the Shares to be
issued in  connection  with the stock  purchase  right,  if any,  that number of
Shares  having a Fair Market Value equal to the amount  required to be withheld.
The Fair Market Value of the Shares to be withheld  shall be  determined  on the
date that the amount of tax to be withheld is to be determined (the "Tax Date").

         All  elections by an Optionee to have Shares  withheld for this purpose
shall be made in writing in a form acceptable to the  Administrator and shall be
subject to the following restrictions:

         (a) the election must be made on or prior to the applicable Tax Date;

         (b) once made,  the election  shall be irrevocable as to the particular
Shares of the Option or Right as to which the election is made;

         (c) all elections shall be subject to the consent or disapproval of the
Administrator;

         (d) if the Optionee is subject to Rule 16b-3,  the election must comply
with the  applicable  provisions  of Rule  16b-3  and shall be  subject  to such
additional  conditions or restrictions as may be required  thereunder to qualify
for the maximum  exemption  from  Section 16 of the Exchange Act with respect to
Plan transactions.

         In the  event  the  election  to  have  Shares  withheld  is made by an
Optionee  and the Tax Date is deferred  under  Section 83 of the Code because no
election is filed under  Section 83(b) of the Code,  the Optionee  shall receive
the full  number of Shares  with  respect to which the Option or stock  purchase
right is  exercised  but such  Optionee  shall be  unconditionally  obligated to
tender back to the Company the proper number of Shares on the Tax Date.

     13.  ADJUSTMENTS UPON CHANGES IN CAPITALIZATION  OR MERGER.  Subject to any
required  action by the  shareholders  of the  Company,  the number of shares of
Common Stock  covered by each  outstanding  Option,  and the number of shares of
Common Stock which have been  authorized  for issuance  under the Plan but as to
which no Options have yet been  granted or which have been  returned to the Plan
upon  cancellation or expiration of an Option, as well as the price per share of
Common Stock covered by each such outstanding  Option,  shall be proportionately
adjusted for any  increase or decrease in the number of issued  shares of Common
Stock  resulting  from a stock  split,  reverse  stock  split,  stock  dividend,
combination or  reclassification  of the Common Stock,  or any other increase or
decrease in the number of issued shares of Common Stock effected without receipt
of  consideration  by the Company;  provided,  however,  that  conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of  consideration."  Such adjustment shall be made by the Board,
whose  determination  in that respect  shall be final,  binding and  conclusive.
Except as  expressly  provided  herein,  no issuance by the Company of shares of
stock of any class, or securities convertible into


                                      -10-
<PAGE>


shares of stock of any class,  shall affect, and no adjustment by reason thereof
shall be made with  respect  to, the  number or price of shares of Common  Stock
subject to an Option.

         In the event of the proposed dissolution or liquidation of the Company,
the Board shall  notify the  Optionee at least  fifteen  (15) days prior to such
proposed action. To the extent it has not been previously exercised,  the Option
will terminate immediately prior to the consummation of such proposed action. In
the event of a merger  or  consolidation  of the  Company  with or into  another
corporation  or the sale of all or  substantially  all of the  Company's  assets
(hereinafter,  a "merger"),  the Option shall be assumed or an equivalent option
shall be substituted by such successor  corporation or a parent or subsidiary of
such successor  corporation.  In the event that such successor  corporation does
not agree to assume the Option or to substitute an equivalent  option, the Board
shall, in lieu of such assumption or  substitution,  provide for the Optionee to
have the right to exercise the Option as to all of the Optioned Stock, including
Shares as to which the Option would not otherwise be  exercisable.  If the Board
makes an Option fully  exercisable in lieu of assumption or  substitution in the
event of a merger,  the Board shall notify the Optionee that the Option shall be
fully  exercisable  for a period  of  fifteen  (15)  days  from the date of such
notice,  and the Option will terminate  upon the expiration of such period.  For
the  purposes of this  paragraph,  the Option  shall be  considered  assumed if,
following  the merger,  the Option or right  confers the right to purchase,  for
each Share of stock subject to the Option  immediately prior to the merger,  the
consideration (whether stock, cash, or other securities or property) received in
the merger by holders of Common Stock for each Share held on the effective  date
of the transaction (and if holders were offered a choice of  consideration,  the
type of  consideration  chosen by the holders of a majority  of the  outstanding
Shares);  provided,  however, that if such consideration  received in the merger
was not solely  common stock of the  successor  corporation  or its Parent,  the
Board may, with the consent of the successor  corporation  and the  participant,
provide for the  consideration  to be received  upon the exercise of the Option,
for each Share of stock subject to the Option,  to be solely common stock of the
successor  corporation or its Parent equal in Fair Market Value to the per share
consideration  received  by  holders  of Common  Stock in the  merger or sale of
assets.

     14. TIME OF GRANTING OPTIONS. The date of grant of an Option shall, for all
purposes,  be the  date on  which  the  Administrator  makes  the  determination
granting such Option,  or such other date as is determined by the Board.  Notice
of the  determination  shall be given to each  Employee or Consultant to whom an
Option is so granted within a reasonable time after the date of such grant.

     15. AMENDMENT AND TERMINATION OF THE PLAN.

     (a)  AMENDMENT  AND  TERMINATION.  The Board may at any time amend,  alter,
suspend or  discontinue  the Plan, but no amendment,  alteration,  suspension or
discontinuation  shall be made which  would  impair  the rights of any  Optionee
under any grant theretofore made,  without his or her consent.  In addition,  to
the extent  necessary and desirable to comply with Rule 16b-3 under the Exchange
Act or with Section 422 of the Code (or any other  applicable law or regulation,
including the requirements of the NASD or an established  stock  exchange),  the


                                      -11-
<PAGE>

Company shall obtain shareholder approval of any Plan amendment in such a manner
and to such a degree as required.

     (b) EFFECT OF AMENDMENT OR  TERMINATION.  Any such amendment or termination
of the Plan shall not affect  Options  already  granted and such  Options  shall
remain  in full  force  and  effect  as if this  Plan  had not been  amended  or
terminated, unless mutually agreed otherwise between the Optionee and the Board,
which agreement must be in writing and signed by the Optionee and the Company.

     16. CONDITIONS UPON ISSUANCE OF SHARES. Shares shall not be issued pursuant
to the exercise of an Option unless the exercise of such Option and the issuance
and  delivery of such Shares  pursuant  thereto  shall  comply with all relevant
provisions of law, including, without limitation, the Securities Act of 1933, as
amended, the Exchange Act, the rules and regulations promulgated thereunder, and
the requirements of any stock exchange upon which the Shares may then be listed,
and shall be further  subject to the  approval of counsel  for the Company  with
respect to such compliance.

         As a condition  to the  exercise of an Option,  the Company may require
the person  exercising  such Option to represent  and warrant at the time of any
such  exercise  that the  Shares are being  purchased  only for  investment  and
without  any  present  intention  to sell or  distribute  such Shares if, in the
opinion of counsel for the Company,  such a representation is required by any of
the aforementioned relevant provisions of law.

     17. RESERVATION OF SHARES. The Company,  during the term of this Plan, will
at all  times  reserve  and keep  available  such  number  of Shares as shall be
sufficient to satisfy the requirements of the Plan.

         The inability of the Company to obtain  authority  from any  regulatory
body having jurisdiction,  which authority is deemed by the Company's counsel to
be necessary  to the lawful  issuance  and sale of any Shares  hereunder,  shall
relieve the Company of any  liability in respect of the failure to issue or sell
such Shares as to which such requisite authority shall not have been obtained.

     18.  AGREEMENTS.  Options and stock  purchase  rights shall be evidenced by
written agreements in such form as the Board shall approve from time to time.

     19.  SHAREHOLDER  APPROVAL.  Continuance  of the Plan  shall be  subject to
approval by the  shareholders of the Company within twelve (12) months before or
after the date the Plan is adopted.  Such shareholder approval shall be obtained
in the degree and manner required under applicable state and federal law.


                                      -12-
<PAGE>


     20.  INFORMATION TO OPTIONEES.  The Company shall provide to each Optionee,
during the period for which such  Optionee has one or more Options  outstanding,
copies of all annual  reports and other  information  which are  provided to all
shareholders  of the Company.  The Company shall not be required to provide such
information  if the  issuance  of  Options  under  the  Plan is  limited  to key
employees  whose duties in  connection  with the Company  assure their access to
equivalent information.


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