COLLAGENEX PHARMACEUTICALS INC
8-K, 1999-05-26
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                       ----------------------------------

                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


Date of report (Date of earliest event reported)   May 12, 1999
                                                --------------------------------


                        COLLAGENEX PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
               (Exact Name of Registrant as Specified in Charter)


       Delaware                     0-28308                     52-1758016
- --------------------------------------------------------------------------------
(State or Other Jurisdiction    (Commission File               (IRS Employer
 of Incorporation)                  Number)                  Identification No.)


41 University Drive
Newtown, Pennsylvania                                              18940
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)                        (Zip Code)


Registrant's telephone number, including area code (215) 579-7388
                                                  ------------------------------


301 South State Street
Newtown, Pennsylvania                                              18940
- --------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)


<PAGE>


ITEM 5.   OTHER EVENTS.


      On  May  12,  1999,  CollaGenex  Pharmaceuticals,   Inc.  (the  "Company")
consummated a $20.0 million financing (the "Financing")  through the issuance of
its Series D Cumulative Convertible Preferred Stock (the "Preferred Stock"). OCM
Principal  Opportunities  Fund, L.P. ("OCM") led the investor group,  which also
included certain current stockholders of the Company.

      The  issuance  of the  Preferred  Stock was  approved by a majority of the
Company's  stockholders  at the Company's  Annual Meeting of Stockholders on May
11,  1999.  The  proceeds of such  Financing  will be used for  general  working
capital  purposes,  including  the  prepayment of a $10 million  Senior  Secured
Convertible  Note  provided  by OCM on March  19,  1999 in  connection  with the
Financing.

      The Preferred Stock is convertible at any time into shares of Common Stock
of the Company at an initial  conversion  price of $11.00 per common share.  The
conversion  price is not  subject to reset  except in the event that the Company
should fail to declare and pay  dividends  when due or the Company  should issue
new equity securities or convertible securities at a price per share or having a
conversion  price per share lower than the then applicable  conversion  price of
the Preferred Stock.

      During the first three years following issuance,  holders of the Preferred
Stock  will be  entitled  to  receive  dividends  payable  in  shares  of  fully
registered Common Stock at a rate of 8.4% per annum. Thereafter,  dividends will
be payable in cash at a rate of 8.0% per annum.


                                      -2-
<PAGE>


ITEM 7.   FINANCIAL  STATEMENTS,  PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

       (c)  Exhibits

            Exhibit No.                         Document
            -----------                         --------

                4.1           Certificate of Designation, Preferences and Rights
                              of Series D Cumulative Convertible Preferred stock
                              of CollaGenex Pharmaceuticals, Inc.

               10.1           Stock Purchase Agreement, dated March 19, 1999, by
                              and among  CollaGenex  Pharmaceuticals,  Inc., OCM
                              Principal   Opportunities   Fund,   L.P.  and  the
                              Purchasers set forth therein  (Incorporated herein
                              by reference to the  Company's  Current  Report on
                              Form 8-K filed with the  Securities  and  Exchange
                              Commission on March 25, 1999.)

               10.2           Stockholders  and Registration  Rights  Agreement,
                              dated  March 19,  1999,  by and  among  CollaGenex
                              Pharmaceuticals, Inc., OCM Principal Opportunities
                              Fund, L.P. and the Purchasers set forth therein.


                                      -3-
<PAGE>


                                    SIGNATURE
                                    ---------


      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.



                               COLLAGENEX PHARMACEUTICALS, INC.


                               By: /s/ Brian M. Gallagher, Ph.D.
                                  --------------------------------------------
                               Name:   Brian M. Gallagher, Ph.D.
                               Title:  President, Chief Executive Officer and
                                       Director


May 25, 1999


                                      -4-
<PAGE>


                                  EXHIBIT INDEX

            Exhibit No.                         Document
            -----------                         --------

                4.1           Certificate of Designation, Preferences and Rights
                              of Series D Cumulative Convertible Preferred stock
                              of CollaGenex Pharmaceuticals, Inc.

               10.1           Stock Purchase Agreement, dated March 19, 1999, by
                              and among  CollaGenex  Pharmaceuticals,  Inc., OCM
                              Principal   Opportunities   Fund,   L.P.  and  the
                              Purchasers set forth therein  (Incorporated herein
                              by reference to the  Company's  Current  Report on
                              Form 8-K filed with the  Securities  and  Exchange
                              Commission on March 25, 1999.)

               10.2           Stockholders  and Registration  Rights  Agreement,
                              dated  March 19,  1999,  by and  among  CollaGenex
                              Pharmaceuticals, Inc., OCM Principal Opportunities
                              Fund, L.P. and the Purchasers set forth therein.


                                      -5-













                                   Exhibit 4.1

               Certificate of Designation, Preferences and Rights
               of Series D Cumulative Convertible Preferred Stock


<PAGE>


                                                                       Exhibit A


              CERTIFICATE OF DESIGNATION, PREFERENCES AND RIGHTS
              OF SERIES D CUMULATIVE CONVERTIBLE PREFERRED STOCK
                                       OF
                        COLLAGENEX PHARMACEUTICALS, INC.

          CollaGenex   Pharmaceuticals,   Inc.,  a  Delaware   corporation  (the
"Corporation"),  pursuant  to the  provisions  of  Section  151  of the  General
Corporation  Law of the State of Delaware  (the  "DGCL"),  does hereby make this
Certificate of Designation  under the corporate seal of the Corporation and does
hereby state and certify that pursuant to the  authority  vested in the Board of
Directors of the Corporation by the Certificate of  Incorporation,  the Board of
Directors has duly adopted the following resolutions:

          RESOLVED,  that  pursuant  to  Article  Fifth  of the  Certificate  of
Incorporation,  as amended (which authorizes five million  (5,000,000) shares of
Preferred  Stock,  par value $0.01 per share,  none of which is presently issued
and  outstanding),  the Board of  Directors  hereby fixes the  designations  and
preferences  and relative  participating,  optional and other special rights and
qualifications,  limitations  and  restrictions  of a series of Preferred  Stock
consisting of 200,000 shares to be designated as Series D Cumulative Convertible
Preferred Stock.

Series D Convertible Preferred Stock
- ------------------------------------

          RESOLVED,   that  the  holders  of  Series  D  Cumulative  Convertible
Preferred Stock, except as otherwise provided by law, shall have and possess the
following rights and preferences.

A. Series D Convertible Preferred Stock.
   ------------------------------------

          1. DESIGNATION, NUMBER OF SHARES. This series of Preferred Stock shall
be  designated as Series D Cumulative  Convertible  Preferred  Stock  ("Series D
Preferred  Stock"),  and the number of shares that shall  constitute such series
shall be 200,000.  The par value of Series D Preferred  Stock shall be $0.01 per
share.

          2. RANK.  With respect to dividend  rights and rights on  liquidation,
winding up and  dissolution of the  Corporation,  Series D Preferred Stock shall
rank senior to:

          (i) the Common Stock, par value $0.01 per share ("Common  Stock"),  of
the Corporation; and

          (ii) each other class of capital stock or class or series of preferred
stock  issued by the  Corporation  after the date  hereof  (in  accordance  with
Paragraph  A.8.(b)(ii)  hereof),  the terms of which shall specifically  provide
that such class or series  shall rank junior to Series D  Preferred  Stock as to
dividend  distributions  or  distributions  upon  liquidation,  winding  up  and
dissolution of the  Corporation  (each of the securities in clauses (i) and (ii)
above collectively referred to as "Junior Securities").


<PAGE>


     3. DIVIDEND PROVISIONS.

          (a) Each  holder of Series D  Preferred  Stock  shall be  entitled  to
receive,  when,  as and if  declared  by the  Board of  Directors,  out of funds
legally available therefor,  dividends on each share of Series D Preferred Stock
as follows:  (i) during the first three (3) years after the date of the original
issuance of the Series D Preferred  Stock (the "Common Stock Dividend  Period"),
the Company  shall pay such  dividends at a rate equal to eight and  four-tenths
percent  (8.4%) per share per annum in fully  paid,  registered,  non-assessable
shares of Common  Stock which shares of such Common Stock shall be valued at one
hundred  percent  (100%) of the  average  trading  price on the NASDAQ  National
Market  ("NASDAQ")  for the  five  (5)  trading  days  immediately  prior to the
Dividend  Declaration  Date (as defined in Paragraph B. hereof);  and (ii) after
the Common Stock Dividend  Period,  the Company shall pay cash dividends on each
share of Series D  Preferred  Stock at a rate  equal to eight  percent  (8%) per
share per annum.  At all times,  dividends  paid in cash shall be paid at a rate
equal to eight  percent  (8%) per share per annum and  dividends  paid in Common
Stock shall be paid at a rate of eight and four-tenths  percent (8.4%) per share
per annum.

          (b) All  dividends,  whether  payable  in cash or in  shares of Common
Stock, shall be cumulative,  whether or not earned or declared, and shall accrue
on a daily  basis  beginning  on the date of the  original  issuance of Series D
Preferred Stock (whether or not funds are legally  available for the declaration
and/or payment of such dividends), and shall be payable semi-annually in arrears
on each Dividend Payment Date (as defined in Paragraph B. hereof), commencing on
the first Dividend Payment Date after the date of the original  issuance of such
Series D Preferred  Stock.  Each  dividend on Series D Preferred  Stock shall be
payable to the holders of record of Series D  Preferred  Stock as they appear on
the stock register of the Corporation on such record date as may be fixed by the
Board of  Directors,  which record date shall not be less than ten (10) nor more
than sixty (60) calendar days prior to the applicable Dividend Payment Date.

          (c)  Commencing  on the  sixth  (6th)  anniversary  of the date of the
original  issuance of the Series D Preferred  Stock,  the annual  dividend  rate
referenced  above in Paragraph  A.3.(a)  shall  increase by one percent (1%) per
annum until the earlier of the date that all of the shares of Series D Preferred
Stock are (i) converted into shares of Common Stock in accordance with Paragraph
A.5. hereof, or (ii) redeemed in accordance with Paragraph A.6. hereof.

          (d) Dividends shall cease to accrue in respect of any shares of Series
D  Preferred  Stock on the date such  shares are (i)  converted  into  shares of
Common Stock in accordance with Paragraph A.5.  hereof,  or (ii) are redeemed in
accordance with Paragraph A.6. hereof.

          (e) Accrued  dividends on the Series D Preferred Stock, if not paid on
the first or any  subsequent  Dividend  Payment Date  following  accrual,  shall
thereafter  accrue  additional  dividends  ("Additional  Dividends")  in respect
thereof,  compounded  semi-annually,   at  the  rate  specified  hereinabove  in
Paragraph  A.3.(a)  hereof or as  specified  hereinbelow  in  Paragraph  A.3.(h)
hereof;  during the first six (6) years after the date of the original  issuance


                                     - 2 -
<PAGE>


of the Series D Preferred Stock, and at the applicable  increased  dividend rate
for each year thereafter.

          (f) All  dividends  paid with  respect to shares of Series D Preferred
Stock  pursuant to  Paragraph  A.3.(a)  shall be paid pro rata to the holders of
Series D Preferred Stock of record entitled thereto.

          (g) Dividends on account of arrears for any past  Dividend  Period may
be declared  and paid at any time,  without  reference  to any regular  Dividend
Payment Date,  to the holders of Series D Preferred  Stock of record on any date
as may be fixed by the Board of  Directors,  which date is not more than  thirty
(30) calendar days prior to the payment of such dividends.

          (h) The dividend payable to holders of Series D Preferred Stock as set
forth above in Paragraph  A.3.(a)  shall be doubled (the  "Default  Dividends"),
which Default  Dividends  shall be payable in either cash or Common Stock at the
choosing  of each  holder of Series D Preferred  Stock upon the  occurrence  and
during  the  continuance  of any of the  following  events  (each an  "Event  of
Default" and  collectively  the "Events of  Default")  not cured or not curable,
upon the giving of written notice thereof to the Corporation by the holders of a
majority of the shares of Series D Preferred Stock then outstanding:

               (i) in the event that the  Corporation  does not (A)  declare the
dividend  payable on the shares of Series D Preferred Stock within (30) calendar
days  of the  Dividend  Declaration  Date,  (B)  fulfill  its  dividend  payment
obligation in full for the Series D Preferred Stock, as set forth herein, within
thirty (30) calendar days after said dividend payment is due and payable, or (C)
fulfill its dividend  payment  obligation in the form of either cash or stock as
required herein; or

               (ii) in the event  that the  Corporation  shall  have  materially
breached any of the representations and warranties contained in any of the Stock
Purchase Agreement or the Stockholders and Registration Rights Agreement and any
registration statement filed by the Company in relation thereto; or

               (iii) in the event that the  Corporation  shall  have  materially
breached  any of the  covenants  or  agreements  contained  in any of the  Stock
Purchase  Agreement or the Stockholders  and  Registration  Rights Agreement and
such  breach  shall not have been cured to the  satisfaction  of the  holders of
record of a majority of the shares of Series D Preferred Stock then  outstanding
within  thirty  (30)  calendar  days  after the date of giving of notice of such
breach to the Corporation; or

               (iv) in the event of the  acceleration of any indebtedness of the
Corporation   with  a  principal   amount  in  excess  of  One  Million  Dollars
($1,000,000); or

               (v) in  the  event  of  the  receipt  of a  final  non-appealable
judgment against the Corporation in an amount that is uninsured in excess of One
Million Dollars ($1,000,000); or


                                     - 3 -
<PAGE>


               (vi) in the  event  that the  Corporation  shall (A) apply for or
consent  to the  appointment  of a  receiver,  trustee  or  liquidator  for  the
Corporation  or any of its  property;  (B) admit in writing its inability to pay
debts  as  they  mature;  (C)  make a  general  assignment  for the  benefit  of
Creditors;  (D) be  adjudicated  bankrupt  or  insolvent;  (E) file a  voluntary
petition  in  bankruptcy,  a petition  or answer  seeking  reorganization  or an
arrangement with creditors to take advantage of any bankruptcy,  reorganization,
insolvency,  readjustment of debt, dissolution or liquidation law or statute, or
an answer  admitting the material  allegations of a petition filed against it in
any  proceeding  under any such law; or (F) have  failed to have an  involuntary
petition in bankruptcy  filed against it dismissed and  discharged  within sixty
(60)  calendar  days after the date of such filing;  corporate  actions shall be
taken for the purpose of effecting any of the foregoing;  or an order,  judgment
or decree shall be entered without the  application,  approval or consent of the
Corporation,  by any  court of  competent  jurisdiction,  approving  a  petition
seeking reorganization of the Corporation or of all or a substantial part of its
assets, and such order, judgment or decree shall continue unstayed and in effect
for sixty (60) calendar days (a "Bankruptcy"); or

               (vii)  in the  event  that  either  (A) any  court  of  competent
jurisdiction  finds that any of the patents owned or licensed by the Corporation
are invalid in any material respect; or (B) any of the patents owned or licensed
by the Corporation materially infringe upon any other patent; provided, however,
that in the event of either (A) or (B), Investor, in good faith, determines that
such finding will have a Material Adverse Effect on the Corporation; or

               (viii) if at any time after the date the first  share of Series D
Preferred  Stock is issued,  shares of Common  Stock are not  actively  publicly
traded on the American Stock Exchange, NASDAQ or NYSE; or

               (ix) in the event that the Corporation consolidates or merges the
Corporation  with or into any  other  corporation  or  corporations,  or  sells,
conveys or disposes of all or substantially all of the assets of the Corporation
or enters into a  transaction  or series of related  transactions  in which more
than fifty  percent  (50%) of the  voting  power of the  Corporation  is sold or
otherwise disposed of (a "Change in Control").

               In  addition  to the  foregoing,  in the event  that the Board of
Directors  continues to fail to declare and pay accrued dividends and/or Default
Dividends on the shares of Series D Preferred  Stock after the  Corporation  has
been notified of an Event of Default in  accordance  with  Paragraph  A.3.(h)(i)
hereof,  which is not  curable or has not been  cured  within the period of time
prescribed for the  Corporation to effectuate such a cure, the holders of record
of a majority  of shares of Series D  Preferred  Stock  shall  have the  option,
during  the  continuance  of such an  Event  of  Default,  to  elect to have the
Conversion  Price reset to the then fair market value of the Common Stock of the
Corporation,  as determined by using the five (5) day trailing  average  closing
price of the Common Stock of the Corporation,  as reported on NASDAQ.  Any reset
of the  Conversion  Price  hereunder  shall be effective on the day  immediately
after the date of the holders' notice to the Corporation.

               Notwithstanding the foregoing,  in the event that the Corporation
is  unable  to meet its  obligation  to pay cash  dividends  in the form of cash
because of (a) a deficiency in the cash


                                     - 4 -
<PAGE>


position  of the  Corporation  such that the payment of such  dividends  in cash
would have a Material Adverse Effect on the Corporation, or (b) a prohibition by
the DGCL,  then the Corporation  shall be permitted to pay Default  Dividends in
shares  of  Common  Stock  during  such  time the  condition  described  in this
paragraph continues.

               (i) The holders of Series D Preferred  Stock shall be entitled to
receive the dividends  provided for in Paragraph A.3.(a) hereof in preference to
and in  priority  over any  dividends  upon any of the Junior  Securities.  Such
dividends on the Series D Preferred  Stock shall be  cumulative,  whether or not
earned  or  declared,  so that if at any time  full  Accumulated  Dividends  (as
defined in Paragraph B. of this  Agreement)  on all shares of Series D Preferred
Stock then  outstanding have not been paid for all Dividend Periods then elapsed
and a prorated  dividend on the Series D Preferred  Stock at the rate  aforesaid
from the Dividend Payment Date immediately preceding the Junior Payment Date (as
defined  below) to the Junior  Payment  Date have not been paid or set aside for
payment,  the amount of such unpaid dividends shall be paid before any sum shall
be set aside for or applied by the  Corporation  to the purchase,  redemption or
other acquisition for value of any shares of Junior Securities  (either pursuant
to any  applicable  sinking fund  requirement  or  otherwise) or any dividend or
other  distribution  shall be paid or declared  and set apart for payment on any
Junior Securities (the date of any such actions to be referred to as the "Junior
Payment  Date");  provided,  however,  that the  restrictions  set forth in this
sentence  shall  not  apply to the  purchase  or  other  acquisition  of  Junior
Securities  pursuant to any  employee or director  incentive  or benefit plan or
arrangement (including any employment, severance or consulting agreement) of the
Corporation  or  any  subsidiary  of the  Corporation  heretofore  or  hereafter
adopted.

               (j) Dividends  payable on Series D Preferred Stock for any period
less  than one (1) year  shall  be  computed  on the  basis  of a  360-day  year
consisting  of twelve  30-day  months plus the actual  number of  calendar  days
elapsed in the month for which such dividends are payable.

     4. LIQUIDATION PREFERENCE.  Upon any voluntary or involuntary  liquidation,
dissolution  or  winding  up of the  Corporation,  the  holders of all shares of
Series D Preferred  Stock then  outstanding  shall be entitled to be paid out of
the assets of the Corporation  available for distribution to its stockholders an
amount in cash equal to One Hundred Dollars ($100.00) in cash per share, plus an
amount equal to full  cumulative  dividends  (whether or not earned or declared)
accrued  and  unpaid  thereon,   including   Default  Dividends  and  Additional
Dividends,   to  the  date  of  final  distribution  and  no  more,  before  any
distribution is made on any Junior Securities. After payment in full pursuant to
this  Paragraph  A.4.,  the  holders of Series D  Preferred  Stock  shall not be
entitled  to any  further  participation  in any  distribution  in the  event of
liquidation, dissolution or winding up of the affairs of the Corporation.

     5. CONVERSION.

          (a) RIGHT OF CONVERSION.  Each share of Series D Preferred Stock shall
be convertible,  at the option of the holder thereof, at any time, and from time
to  time,  after  the date of  issuance  of such  share,  at the  office  of the
Corporation  or any transfer agent for the Series D Preferred  Stock,  into such
number of fully paid,  registered,  non-assessable  shares of Common Stock as is
determined by dividing One Hundred  Dollars  ($100.00) by the Conversion  Price.


                                     - 5 -
<PAGE>


The "Conversion  Price" for the Series D Preferred Stock shall be Eleven Dollars
($11.00) per share.  The Conversion Price for the Series D Preferred Stock shall
be subject to adjustment as set forth in Paragraph A.5.(c) hereof.

          (b) PROCEDURES FOR VOLUNTARY  CONVERSION.  Before any holder of shares
of Series D Preferred Stock shall be entitled to convert any of such shares into
shares  of  Common  Stock,  such  holder  shall  surrender  the  certificate  or
certificates therefor, duly endorsed, at the office of the Corporation or of any
transfer agent for the Series D Preferred  Stock,  and shall give written notice
by mail, postage prepaid, or hand delivery,  to the Corporation at its principal
corporate  office,  of the election to convert the same and shall state  therein
the name or names in which the certificate or certificates  for shares of Common
Stock  are  to  be  issued.  The  Corporation  shall,  as  soon  as  practicable
thereafter, issue and deliver at such office to such holders of shares of Series
D Preferred Stock, or to the nominee or nominees of such holders,  a certificate
or  certificates  for the number of shares of Common  Stock to which such holder
shall be entitled as  aforesaid.  Such  conversion  shall be deemed to have been
made immediately prior to the close of business on the date of such surrender of
the  shares of  Series D  Preferred  Stock to be  converted,  and the  person or
persons  entitled  to receive  the  shares of Common  Stock  issuable  upon such
conversion  shall be treated for all purposes as the record holder or holders of
such shares of Common Stock as of such date. If the  conversion is in connection
with  an  underwritten   offering  of  securities  registered  pursuant  to  the
Securities  Act of 1933, as amended,  the  conversion  may, at the option of any
holder  tendering the Series D Preferred  Stock for  conversion,  be conditioned
upon the effectiveness of such offering,  in which event the person(s)  entitled
to receive Common Stock issuable upon such  conversion of the Series D Preferred
Stock shall not be deemed to have converted such Series D Preferred  Stock until
immediately  prior to the  effectiveness  of such  offering and the  Corporation
shall deliver to such holders  tendering Series D Preferred Stock for conversion
written notice of the anticipated  date of such  effectiveness  no less than ten
(10) calendar days prior thereto.

          (c) ADJUSTMENTS OF CONVERSION PRICE. So long as any shares of Series D
Preferred Stock are outstanding,  the Conversion Price of the Series D Preferred
Stock shall be subject to adjustment from time to time as follows:

               (i)  (A)  Upon  issuance  (or  deemed  issuance  pursuant  to the
provisions hereof) by the Corporation of any Additional Stock (as defined below)
after the date of issuance of Series D Preferred Stock, without consideration or
for an Effective Price per share, or, in the case of Convertible  Securities,  a
conversion  price per  share,  less than the  Conversion  Price for the Series D
Preferred Stock in effect immediately prior to the issuance (or deemed issuance)
of such Additional  Stock,  then the Conversion Price for the Series D Preferred
Stock in effect  immediately  prior to each (such  issuance or deemed  issuance)
shall be adjusted,  if the issuance  occurs after the initial  twelve (12) month
period after the date of original issuance of the Series D Preferred Stock, to a
price determined by the following  formula:  (A + B) / (C + D), where "A" equals
the  number  of shares of Common  Stock  outstanding  immediately  prior to such
issuance or sale multiplied by the then applicable  Conversion Price,  where "B"
equals the consideration, if any, received by the Corporation upon such issuance
or sale, where "C" equals the total number of shares of Common Stock outstanding
prior to issuance of the  additional  shares and where "D" equals any Additional
Stock or any conversion  shares, or any other shares


                                     - 6 -
<PAGE>


reserved for issuance  which are  associated  with such  financing,  immediately
after such issuance or sale.  See Exhibit A hereto for an example of the formula
set forth herein.

                    (B) No  adjustment  of the  Conversion  Price  for  Series D
Preferred  Stock  shall be made in an  amount  less  than  one-half  of One Cent
($0.005) per share,  provided that any adjustments  which are not required to be
made by reason of this sentence shall be carried forward and shall be taken into
account in any subsequent  adjustment to the Conversion  Price. No adjustment of
the Conversion Price for the Series D Preferred Stock pursuant to this Paragraph
A.5.(c)(i)  shall have the effect of increasing  such  Conversion  Price for the
Series D Preferred Stock above the Conversion Price in effect  immediately prior
to such adjustment.

                    (C) In  the  case  of  the  issuance  of  securities  of the
Corporation  for cash, the amount of  consideration  received by the Corporation
for such  securities  shall be  deemed to be the  amount  of cash paid  therefor
before deducting any discounts,  commissions or other expenses allowed,  paid or
incurred by the Corporation for any underwriting or otherwise in connection with
the issuance and sale thereof.

                    (D) In  the  case  of  the  issuance  of  securities  of the
Corporation  for a  consideration  in  whole or in part  other  than  cash,  the
consideration  other than cash shall be deemed to have a dollar  value  equal to
the  fair  market  value of such  non-cash  consideration,  irrespective  of any
accounting  treatment  thereof,  as  determined by a vote of the majority of the
Board of  Directors  including  the  affirmative  vote of the Series D Preferred
Director.

                    (E) In the case of the issuance (whether before, on or after
the date of  issuance  of Series D  Preferred  Stock) of Options or  Convertible
Securities,  the  following  provisions  shall  apply for all  purposes  of this
Paragraph A.5.(c)(i) and Paragraph A.5.(c)(ii) hereof:

          (1) With respect to Options to purchase  Common  Stock,  the aggregate
          maximum number of shares of Common Stock  deliverable upon exercise of
          such  Options  shall be deemed  to have  been  issued at the time such
          Options were issued and for a consideration equal to the consideration
          (determined in the manner provided in Subparagraph  A.5.(c)(i)(C)  and
          Subparagraph   A.5.(c)(i)(D)   hereof),   if  any,   received  by  the
          Corporation for such Options plus the minimum  exercise price provided
          in such Options for Common Stock issuable thereunder.

          (2) With  respect to  Convertible  Securities  and Options to purchase
          Convertible  Securities,  the  aggregate  maximum  number of shares of
          Common Stock  deliverable  upon the conversion or exchange of any such
          Convertible  Securities and the aggregate  maximum number of shares of
          Common  Stock  issuable  upon the exercise of such Options to purchase
          Convertible  Securities and the  subsequent  conversion or exchange of
          such Convertible Securities shall be deemed to have been issued at the
          time such Convertible Securities or such Options were issued and for a
          consideration  equal to the  consideration,  if any,  received  by the
          Corporation for any such Convertible  Securities and Options, plus


                                     - 7 -
<PAGE>


          the minimum  additional  consideration,  if any, to be received by the
          Corporation  upon  the  conversion  or  exchange  of such  Convertible
          Securities  or the  exercise  of such  Options and the  conversion  or
          exchange of the Convertible  Securities issuable upon exercise of such
          Options (the consideration in each case to be determined in the manner
          provided in Subparagraphs A.5.(c)(i)(C) and A.5.(c)(i)(D) hereof).

          (3) In the event of any change in the number of shares of Common Stock
          deliverable, or in the consideration payable to the Corporation,  upon
          exercise  of such  Options  or upon  conversion  or  exchange  of such
          Convertible  Securities,  including,  but not  limited  to,  a  change
          resulting from the  antidilution  provisions  thereof,  the Conversion
          Price of the  Series  D  Preferred  Stock,  to the  extent  in any way
          affected by or computed using such Options or Convertible  Securities,
          shall be recomputed to reflect such change,  but no further adjustment
          shall be made for the actual  issuance of Common  Stock or any payment
          of such  consideration  upon the  exercise of any such  Options or the
          conversion or exchange of such Convertible Securities.

          (4) Upon the expiration or termination of any such Options or any such
          rights to convert or exchange Convertible  Securities,  the Conversion
          Price of the  Series  D  Preferred  Stock,  to the  extent  in any way
          affected by or computed using such Options or Convertible  Securities,
          shall be  recomputed  to reflect  the  issuance  of only the number of
          shares of Common Stock (and Options and Convertible  Securities  which
          remain in effect) that were actually  issued upon the exercise of such
          Options  or upon  the  conversion  or  exchange  of  such  Convertible
          Securities.

          (5) The  number  of  shares  of Common  Stock  deemed  issued  and the
          consideration   deemed  paid   therefor   pursuant  to   Subparagraphs
          A.5.(c)(i)(E)(1)  and (2) hereof  shall be  appropriately  adjusted to
          reflect any change, termination or expiration of the type described in
          either Subparagraph A.5.(c)(i)(E)(3) or (4) hereof.

               (ii) "Additional  Stock" shall mean any shares of Common Stock or
shares of Common Stock  issuable  pursuant to Convertible  Securities  issued or
Options  (or deemed to have been  issued  pursuant  to  Paragraph  A.5.(c)(i)(E)
hereof) by the  Corporation  after the date of  issuance  of Series D  Preferred
Stock, except:

                    (A) Common Stock issued pursuant to a transaction  described
in Paragraph A.5.(c)(iii) hereof;

                    (B) Common  Stock or options to purchase  such Common  Stock
issued  to  officers,   employees  or  directors  of,  or  consultants  to,  the
Corporation,  pursuant to any  agreement,  plan or  arrangement  approved by the
Board of  Directors  of the  Corporation;  provided,  however,  that the maximum
number of shares of Common  Stock  heretofore  or  hereafter  issued or issuable
pursuant  to all such  agreements,  plans and  arrangements  shall not exceed an
aggregate (as  constituted  on the date hereof) of Two Million Three Hundred Two
Thousand (2,302,000) shares of Common Stock ("Permitted Options"); and


                                     - 8 -
<PAGE>


                    (C) Common  Stock  issued or  issuable  upon  conversion  of
shares of Series D Preferred Stock.

               (iii) In the  event the  Corporation  at any time or from time to
time after the date of issuance of Series D Preferred  Stock fixes a record date
for the  effectuation  of a split or  subdivision of the  outstanding  shares of
Common Stock or the  determination of holders of shares of Common Stock entitled
to receive a dividend  or other  distribution  payable in  additional  shares of
Common Stock or other  securities or rights  convertible  into, or entitling the
holder thereof to receive  directly or indirectly,  additional  shares of Common
Stock (hereinafter referred to as "Common Stock Equivalents") without payment of
any  consideration  by such holder for the additional  shares of Common Stock or
Common  Stock  Equivalents  (including  the  additional  shares of Common  Stock
issuable upon conversion or exercise thereof),  then, as of such record date (or
the date of such dividend,  distribution, split or subdivision if no record date
is  fixed),  the  Conversion  Price of the  Series D  Preferred  Stock  shall be
appropriately decreased so that the number of shares of Common Stock issuable on
conversion  of each share of Series D  Preferred  Stock  shall be  increased  in
proportion  to such  increase in the  aggregate  number of shares  issuable with
respect to Common Stock  Equivalents,  with the number of shares  issuable  with
respect to Common Stock  Equivalents  determined from time to time in the manner
provided for deemed issuances in Subparagraph A.5.(c)(i)(E) hereof.

               (iv) If the number of shares of Common Stock  outstanding  at any
time after the date of issuance of Series D Preferred  Stock is  decreased  by a
combination  of the  outstanding  shares of Common  Stock,  then,  following the
record date of such combination, the Conversion Price for the Series D Preferred
Stock shall be  appropriately  increased  so that the number of shares of Common
Stock issuable on conversion of each share of Series D Preferred  Stock shall be
decreased in  proportion to such  decrease in the  outstanding  shares of Common
Stock.

          (d) OTHER DISTRIBUTIONS.  In the event the Corporation shall declare a
distribution  payable in securities of other persons,  evidences of indebtedness
issued by the Corporation or other persons, assets (excluding cash dividends) or
options or rights not referred to in Paragraph  A.5.(c)(iii)  hereof,  then,  in
each such case for the purpose of this Paragraph A.5.(d),  the holders of shares
of Series D Preferred  Stock shall be entitled to a  proportionate  share of any
such  distribution as though they were holders of the number of shares of Common
Stock into which their shares of Series D Preferred  Stock are convertible as of
the record date fixed for the  determination  of the holders of shares of Common
Stock entitled to receive such distribution.

          (e) RECAPITALIZATION.  If at any time or from time to time there shall
be a  recapitalization  or  reclassification  of  Common  Stock  (other  than  a
subdivision,  combination  or  consolidation,  merger or sale of assets or stock
transaction  provided for in Paragraph A.6. hereof),  provision shall be made so
that each  holder of shares of Series D  Preferred  Stock  shall  thereafter  be
entitled to receive, upon conversion of the Series D Preferred Stock, the number
of  shares  of stock or other  securities  or  property  of the  Corporation  or
otherwise, receivable upon such recapitalization or reclassification by a holder
of the  number of shares of Common  Stock  into  which  such  shares of Series D
Preferred   Stock  could  have  been   converted   immediately   prior  to  such
recapitalization.  In any such case, appropriate adjustment shall be made in the


                                     - 9 -
<PAGE>


application  of the provisions of this Paragraph A.5. with respect to the rights
of the holders of shares of Series D Preferred Stock after the  recapitalization
or  reclassification  to the end  that the  provisions  of this  Paragraph  A.5.
(including  adjustments of the Conversion Price then in effect and the number of
shares  purchasable  upon  conversion of the Series D Preferred  Stock) shall be
applicable after that event as nearly equivalent as may be practicable.

          (f) NO  IMPAIRMENT.  The  Corporation  will not, by  amendment of this
Certificate of Incorporation or through any reorganization,  recapitalization or
any other voluntary action, avoid or seek to avoid the observance or performance
of any of the terms to be observed or performed  hereunder  by the  Corporation,
but will at all  times  in good  faith  assist  in the  carrying  out of all the
provisions of this Paragraph A.5. and in the taking of all such action as may be
necessary  or  appropriate  in order to  protect  the  conversion  rights of the
holders of shares of Series D Preferred Stock against impairment.

          (g) NO FRACTIONAL  SHARES.  No fractional  shares shall be issued upon
conversion of the Series D Preferred  Stock,  and the number of shares of Common
Stock to be issued shall be rounded upward to the nearest whole share, and there
shall be no  payment to a holder of shares of Series D  Preferred  Stock for any
such rounded fractional share. Whether or not fractional shares result from such
conversion  shall be  determined  on the basis of the total  number of shares of
Series D Preferred  Stock the holder is at the time converting into Common Stock
and  the  number  of  shares  of  Common  Stock  issuable  upon  such  aggregate
conversion.

          (h)  CERTIFICATE  AS TO  ADJUSTMENTS.  Upon  the  occurrence  of  each
adjustment or  readjustment  of the  Conversion  Price of the Series D Preferred
Stock pursuant to this Paragraph A.5., the  Corporation,  at its expense,  shall
promptly  compute such  adjustment or  readjustment in accordance with the terms
hereof and  prepare  and  furnish to each holder of shares of Series D Preferred
Stock a certificate setting forth such adjustment or readjustment and showing in
detail the facts upon which such adjustment or readjustment is based,  certified
by the  Corporation's  President or Chief  Financial  Officer.  The  Corporation
shall,  upon the written request at any time of any holder of shares of Series D
Preferred  Stock,  furnish  or  cause  to be  furnished  to such  holder  a like
certificate  setting  forth  (i)  such  adjustment  and  readjustment,  (ii) the
Conversion Price at the time in effect, and (iii) the number of shares of Common
Stock and the  amount,  if any,  of other  property  which at the time  would be
received upon the conversion of a share of Series D Preferred Stock.

          (i)  NOTICES  OF  RECORD  DATE.  In the  event  of any  taking  by the
Corporation  of a record  of the  holders  of any  class of  securities  for the
purpose of  determining  the  holders  thereof  who are  entitled to receive any
dividend  (other  than a cash  dividend)  or other  distribution,  any  right to
subscribe for, purchase or otherwise acquire any shares of stock of any class or
any other securities or property, or to receive any other right, the Corporation
shall mail to each holder of shares of Series D Preferred Stock, at least twenty
(20) calendar days prior to the date specified  therein, a notice specifying the
date on which any such record is to be taken for the  purpose of such  dividend,
distribution  or  right,   and  the  amount  and  character  of  such  dividend,
distribution or right.

          (j)  RESERVATION OF STOCK  ISSUABLE UPON  CONVERSION,  DIVIDENDS.  The
Corporation  shall at all  times  take  appropriate  steps to  reserve  and keep
available out of its


                                     - 10 -
<PAGE>


authorized  but unissued  shares of Common Stock,  solely for the purpose of (i)
effecting the conversion of the shares of Series D Preferred Stock,  such number
of its shares of Common Stock as shall from time to time be sufficient to effect
the conversion of all outstanding  shares of Series D Preferred  Stock, and (ii)
the payment of dividends as  contemplated in Paragraph  A.3.(a).  If at any time
the  number of  authorized  but  unissued  shares of Common  Stock  shall not be
sufficient to effect the conversion of all then  outstanding  shares of Series D
Preferred  Stock or the  payment of  dividends,  then in  addition to such other
remedies  as shall  be  available  to the  holder  of such  shares  of  Series D
Preferred  Stock, the Corporation will take such corporate action as may, in the
opinion of its counsel,  be necessary  to increase its  authorized  but unissued
shares of Common Stock to such number of shares as shall be sufficient  for such
purposes.

          (k) NOTICES.  Any notice  required by the provisions of this Paragraph
A.5. to be given to the  holders of shares of Series D Preferred  Stock shall be
deemed given when  received if delivered  via courier or sent by  facsimile,  by
telex, or by United States mail,  postage prepaid,  and addressed to each holder
of record at his, her or its address appearing on the books of the Corporation.

          (l) MANDATORY CONVERSION.

               (i) All or a portion  of the shares of Series D  Preferred  Stock
shall,  at the  option  of the  Corporation  (as  determined  by  the  Board  of
Directors),   automatically  be  converted  into  fully  paid,   registered  and
non-assessable  shares of Common Stock in accordance  with Paragraph  A.5.(a)(i)
above, if at any time after the date the first share of Series D Preferred Stock
is issued, the following two conditions are met:

                    (A) the Closing  Common  Stock  Market  Price (as defined in
Paragraph B.(d) hereof) for forty (40) consecutive  trading days is at least two
hundred percent (200%) of the Conversion Price then in effect; and

                    (B) an effective  shelf  registration  (in  accordance  with
Section 5(b) of the Stockholders and Registration Rights Agreement) is in effect
for the shares of Common  Stock to be issued  upon  conversion  of the shares of
Series D Preferred Stock.

               (ii) If the Corporation has elected to convert Series D Preferred
Stock into Common Stock pursuant to Paragraph  A.5.(l)(i) above, the Corporation
will  provide  written  notice  of  mandatory  conversion  of shares of Series D
Preferred  Stock to each  holder of record of Series D  Preferred  Stock no less
than thirty (30) nor more than sixty (60)  calendar days prior to the date fixed
for  conversion  by first class mail,  postage  prepaid,  to each holder at such
holder's  address as it appears on the stock  register of the  Corporation.  The
Corporation's  obligation  to  deliver  shares of Common  Stock  shall be deemed
fulfilled if, on the mandatory  conversion  date, the Corporation  shall deposit
with a bank or trust  company in New York,  New York having  capital of at least
One  Hundred  Million  Dollars  ($100,000,000),  such number of shares of Common
Stock as are required to be delivered by the Corporation  upon the conversion of
the shares of Series D Preferred  Stock so called for  conversion.  Provided the
Corporation  has fulfilled its  obligation to deposit  shares as provided in the
foregoing  sentence,  effective on the  mandatory  conversion  date fixed by the
Corporation  and  notified  to the  holders of Series D  Preferred  Stock,  each
outstanding  share of Series D Preferred  Stock shall be converted  into a


                                     - 11 -
<PAGE>


fully  paid,  registered,  and  non-assessable  share  of  Common  Stock  at the
Conversion  Price then in effect,  automatically  and  without any action on the
part of any holder of shares of Series D Preferred Stock, and each such share of
Common Stock shall be deemed outstanding from and after the mandatory conversion
date.

     6. OPTIONAL REDEMPTION.

          (a) If at any time after the date of  original  issuance of the shares
of Series D Preferred  Stock less than five percent (5%) of the shares of Series
D Preferred Stock originally  issued are outstanding,  the Corporation  shall be
entitled,  at the  Corporation's  option,  to  redeem  the  shares  of  Series D
Preferred  Stock then  outstanding  for an amount  equal to one hundred  percent
(100%) of the  original  issue  price per share plus an amount  equal in full to
cumulative  accrued  dividends and Default  Dividends  (whether or not earned or
declared) accrued and unpaid thereon.

          (b) In the event that on and after the third (3rd)  anniversary of the
date of the  original  issuance of the Series D Preferred  Stock and  continuing
until the fifth  (5th)  anniversary  thereof a Change  in  Control  occurs,  the
Corporation  shall be  entitled,  at its option,  to redeem all of the shares of
Series D Preferred  Stock then  outstanding  for an amount  equal to one hundred
twenty percent  (120%) per share of the  liquidation  preference  plus an amount
equal in full to cumulative  accrued dividends and Default Dividends (whether or
not earned or  declared)  accrued and unpaid  thereon  from the date of original
issuance of the Series D Preferred Stock until the date of redemption.

          (c) If at any time after the fifth  (5th)  anniversary  of the date of
the  original  issuance  of the  Series D  Preferred  Stock a Change in  Control
occurs,  the Corporation shall be entitled,  at its option, to redeem all of the
shares of Series D Preferred  Stock then  outstanding for an amount equal to one
hundred  percent (100%) per share of the  liquidation  preference plus an amount
equal in full to  cumulative  dividends  and Default  Dividends  (whether or not
earned  or  declared)  accrued  and  unpaid  thereon  from the date of  original
issuance of the Series D Preferred Stock until the date of redemption.

          (d) If the  Corporation  elects to  redeem  Series D  Preferred  Stock
pursuant to this  Paragraph  6A.(a),  (b) or (c), the  Corporation  will provide
written notice of such optional redemption of shares of Series D Preferred Stock
to each holder of record of Series D  Preferred  Stock not less than thirty (30)
calendar  days  prior to the date  fixed for  redemption  by first  class  mail,
postage  prepaid,  to each holder and such holder's address as it appears on the
stock register of the Corporation.

     7. STATUS OF CONVERTED STOCK. In the event any shares of Series D Preferred
Stock are converted to Common Stock  pursuant to Paragraph A.5.  hereof,  or are
redeemed by the  Corporation  pursuant to Paragraph A.6.  hereof,  the shares so
converted or so redeemed shall be canceled, retired and eliminated and shall not
be  reissued  by  the  Corporation.  The  Certificate  of  Incorporation  of the
Corporation shall be appropriately amended to effect the corresponding reduction
in the Corporation's authorized capital stock.

     8. VOTING RIGHTS.


                                     - 12 -
<PAGE>


          (a) GENERAL. The holders of Series D Preferred Stock shall be entitled
to vote  together with the holders of Common Stock on all matters to be voted on
by the Corporation on an as-converted basis.

          (b) CLASS VOTING RIGHTS.

               (i)  Except as  otherwise  provided  below,  a vote of at least a
majority of the shares of the Series D Preferred Stock then outstanding shall be
sufficient to take any action requiring the vote of the Series D Preferred Stock
as a separate  class.  At any meeting  where the Series D Preferred  Stock shall
have the right to vote as a separate class, the presence, in person or by proxy,
of a majority of the then  outstanding  shares of Series D Preferred Stock shall
constitute a quorum of such class.

               (ii) So long as any Series D Preferred Stock is outstanding,  the
Corporation  shall not,  without the affirmative vote of the holders of at least
sixty-six and two-thirds percent (66 2/3%) of all outstanding shares of Series D
Preferred  Stock  voting  separately  as a class,  given in  person or by proxy,
either in writing  or by  resolution  adopted  at an annual or  special  meeting
called  for this  purpose  (A)  amend,  alter or  repeal  any  provision  of the
Certificate of Incorporation or By-laws of the Corporation,  each as amended, so
as to affect,  in any manner adverse to the holders of Series D Preferred Stock,
the relative rights, preferences, qualifications, limitations or restrictions of
the Series D Preferred Stock; (B) create, authorize, designate or reclassify any
authorized stock of the Corporation  into, or increase the authorized amount of,
or issue any capital  stock that ranks senior to or pari passu with the Series D
Preferred Stock, or any Junior Securities,  whether voluntary or involuntary, or
any security  convertible into such a class or series,  which are required to be
redeemed  by the  Corporation  at any time that any shares of Series D Preferred
Stock are  outstanding;  (C) during the first twelve (12) months  after  Closing
issue Common  Stock or  securities  convertible  into Common Stock at a price or
conversion  price (except  options under the Option Plans) below the  Conversion
Price  then in  effect;  or (D) take any other  action on which the  holders  of
Series D Preferred Stock shall be entitled by law to vote separately as a class.

               (iii) The  Corporation  shall not,  without the  express  written
approval  of the  holders  of record  of a  majority  of the  shares of Series D
Preferred Stock then outstanding take any of the following actions:

                    (A) DIVIDENDS.  The Corporation shall not declare or pay any
dividend or distribution on any shares of capital stock of the Corporation other
than dividends on Series D Preferred Stock.

                    (B)  INDEBTEDNESS.  The Corporation and its subsidiary shall
not (x)  incur  any  indebtedness  for  borrowed  money  or  guarantee  any such
indebtedness of another person, issue or sell any debt securities or warrants or
other rights to acquire any debt  securities of the  Corporation,  guarantee any
debt securities of another person, enter into any "keep well" or other agreement
to maintain any financial  statement  condition of another  person or enter into
any arrangement having the economic effect of any of the foregoing,  except that
the  Corporation  may incur  such  indebtedness  in any amount not to exceed Ten
Million Dollars  ($10,000,000) in the aggregate outstanding at any time only for
the  Corporation's  working


                                     - 13 -
<PAGE>


capital  requirements  in the  ordinary  course of  business  ("Working  Capital
Loans");  or (y) make any  loans,  advances  of  capital  contributions  to,  or
investments  in,  any  other  person,  other  than  to  the  Corporation  or its
subsidiaries.

                    (C)  DISPOSITIONS.  The Corporation  shall not enter into or
effect  a  recapitalization,   corporate  reorganization   (including,   without
limitation,  any  distribution of assets to a subsidiary of the  Corporation) or
liquidation,  sell,  assign,  lease or otherwise  dispose  (including  by way of
mortgage, license, encumbrance or any lien) of any assets or securities,  except
for (i)  transactions  in the  ordinary  course of  business or (ii) any pledge,
assignment,  encumbrance,  lien or other  disposition of working  capital assets
(accounts receivable and inventory) directly related to the Working Capital Loan
(as defined in Section 2(b)(ii) above), or effectuate any split,  subdivision or
combination  of any Equity  Securities,  or enter into a  material  contract  or
release or relinquish any material contract rights not in the ordinary course of
business, or make any amendments, or modifications thereto.  Notwithstanding the
foregoing,  the  Corporation  shall not,  at any time,  sell,  assign,  lease or
otherwise dispose (including by way of pledge, mortgage, license, encumbrance or
any lien) of any license,  patent or Intellectual  Property of the  Corporation,
except in the ordinary course of business,  without the express written approval
of the  holders of a majority  of the  shares of Series D  Preferred  Stock then
outstanding. For purposes of the foregoing sentence, ordinary course of business
shall  include,  without  limitation,  (a)  licenses  for  purposes of research,
development,   manufacturing,   marketing   and/or   distribution  and  (b)  the
abandonment of any Intellectual Property which the Corporation  determines is of
insignificant benefit to the Corporation and which could not, individually or in
the aggregate, have a Material Adverse Effect on the Corporation.

                    (D) RESEARCH AND DEVELOPMENT  EXPENDITURES.  The Corporation
shall not make research and development  expenditures in excess of Seven Million
Dollars ($7,000,000) in any one (1) continuous twelve (12) month period,  unless
the Corporation has reported positive net income  (calculated in accordance with
generally accepted accounting principles  consistently applied,  reported on all
necessary  and  appropriate  filings of SEC  Documents  and only  excluding  any
extraordinary  or unusual gains) for four (4) consecutive  quarters  immediately
prior to such twelve (12) month period.

                    (E)  ACQUISITIONS.   The  Corporation  shall  not  merge  or
consolidate  with,  purchase,  lease or otherwise make any acquisition of all or
substantially  all of the assets,  properties  or  securities  of, any person or
entity in a transaction or series of related transactions with any calendar year
period in excess of Ten Million Dollars ($10,000,000).

                    (F) PROTECTIVE  AGREEMENTS.  The Corporation  shall not: (i)
enter into any non-disclosure  agreement,  that is not substantially in the form
utilized by the  Corporation  as of the effective  date of this  Certificate  of
Designation,  with each new employee  hired after the date of Closing;  and (ii)
enter into any non-competition  agreement, that is not substantially in the form
utilized  by the  Corporation,  with each new  officer  hired  after the date of
Closing.  The Corporation  shall not terminate,  amend or modify in any material
respect any agreement relating to matters of non-disclosure or non-competition.


                                     - 14 -
<PAGE>


                    (G) BENEFIT PLANS. The Corporation  shall not adopt or amend
in any  material  respect any  collective  bargaining  agreement or any Employee
Benefit Plan of the Corporation which,  individually or in the aggregate,  could
reasonably by expected to have a Material Adverse Effect.

          (c) BOARD OF  DIRECTORS.  The Board of  Directors  of the  Corporation
shall consist of not less than five (5) and not more than nine (9) directors. At
each annual meeting of the stockholders of the Corporation,  and at each special
meeting  of the  stockholders  of the  Corporation  called  for the  purpose  of
electing directors of the Corporation,  and at any time at which stockholders of
the  Corporation  shall  have the right to, or  shall,  vote for or  consent  in
writing to the election of directors of the Corporation,  then, and in each such
event, until the occurrence of an Event of Default, (i) the holders of record of
shares of Series D Preferred  Stock voting together as a separate class shall be
entitled,  but not obligated,  to elect one (1) director, who shall be nominated
by the holders of record of a majority of the shares of Series D Preferred Stock
then outstanding (the "Series D Preferred Stock Director"), and (ii) the holders
of record of shares of Common Stock shall elect the remaining directors, up to a
maximum of eight (8),  all of whom shall be  nominated by the Board of Directors
of the Corporation (collectively,  the "Common Directors").  At any such meeting
called for the purpose of electing directors, the presence in person or by proxy
of (i) the  holders of record of a majority  of the shares of Series D Preferred
Stock then  outstanding,  in the case of the  election of the Series D Preferred
Stock  Director  and (ii) the  holders of record of a majority  of the shares of
each of the Common  Stock,  in the case of the  election  of a Common  Director,
shall  constitute  a quorum for the  election of directors to be elected by such
holders. A vacancy in any directorship  entitled to be elected by the holders of
record of shares of Series D Preferred Stock (including  without  limitation,  a
vacancy resulting from the decision during an earlier election by the holders of
the  Series D  Preferred  Stock not to fill the  directorship  to be held by the
Series D  Preferred  Stock  Director)  shall be filled  only by vote or  written
consent of the holders of record of shares of Series D Preferred  Stock,  in the
manner set forth herein. A vacancy in any directorship elected by the holders of
record of Common  Stock shall be filled  only by vote or written  consent of the
holders of record of shares of Common  Stock,  in the  manner set forth  herein.
Each Common  Director who shall have been elected as provided in this  Paragraph
A.8.(c) may be removed during his or her term of office, whether with or without
cause, only by the holders of record of a majority of the shares of Common Stock
then outstanding, and each Series D Preferred Stock Director who shall have been
elected as provided in this  Paragraph  A.8.(c) may be removed during his or her
term of office,  whether  with or without  cause,  by the holders of record of a
majority of the shares of Series D Preferred Stock then outstanding. Each Common
Director and the Series D Preferred  Stock Director shall be entitled to one (1)
vote on all  matters  which  directors  are  entitled to vote on. The holders of
record of a majority of the shares of Series D Preferred Stock then  outstanding
shall have the right to call meetings of the Board of Directors  and  management
of the  Corporation,  upon no less than five (5)  calendar  days' prior  written
notice; provided, that such meetings are called no more frequently than once per
fiscal  quarter;  and,  provided,  further,  so long as no Event of Default  has
occurred  or is  continuing,  a  meeting  may be  called  only if the  Board  of
Directors  has not held a board  meeting or  scheduled  a board  meeting for the
calendar  quarter in which such holders of Series D Preferred Stock seek to call
a meeting.  During  such time as holders of record of a majority of the Series D
Preferred  Stock then  outstanding  are entitled to elect the Series D Preferred
Stock Director to the Board of Directors, such holders


                                     - 15 -
<PAGE>


shall also be entitled to have such Series D Preferred  Stock  Director serve on
the compensation  committee of the Board of Directors and any special  committee
created by the Board of Directors not in the ordinary course of business and the
Corporation  shall  cause  such  Series  D  Preferred  Stock  Director  to be so
appointed;  provided,  however,  that if such Series D Preferred  Stock Director
would not be considered "independent" or "disinterested" (i) for purposes of any
applicable rule of NASDAQ or (ii) for purposes of any special  committee  formed
in  connection  with any  transaction  or potential  transaction  involving  the
Corporation  and Investor or any Purchaser,  then such Series D Preferred  Stock
Director shall not be eligible to be appointed to such committee.

     9. LACK OF PUBLIC MARKET. If the Common Stock of the Corporation  ceases to
be listed or authorized to be quoted on any national  securities exchange or the
public market for the Common Stock of the Corporation otherwise ceases to exist,
the Corporation  shall engage an investment bank,  reasonably  acceptable to the
Corporation  and the holders of record of a majority of the shares of the Series
D Preferred Stock, to determine the fair market value price of the Common Stock,
from time to time, in connection with Paragraphs A.3., A.5. and A.6.

B.   Definitions.  As used herein,  the following terms shall have the following
     -----------
     definitions:

               (a)  "Accumulated  Dividends"  means with respect to any share of
Series D Preferred  Stock,  the dividends that have accrued on such shares as of
such specific date for Dividend Periods ending on or prior to such date and that
have not  previously  been  paid in cash,  including  Additional  Dividends  and
Default Dividends.

               (b) "Additional  Dividends" has the meaning given to such term in
Paragraph A.(3)(e).

               (c)  "Additional  Stock" has the meaning  set forth in  Paragraph
A.(5)(c)(ii).

               (d) "Closing  Common  Stock  Market  Price" for any day means the
last sale price  regular  way, or, in case no such sale takes place on such day,
the average of the closing bid and asked  prices  regular way, in either case as
reported  on  American  Stock  Exchange,  NASDAQ,  NYSE  or any  other  national
securities market.

               (e)  "Common  Stock  Equivalents"  has the  meaning  set forth in
Paragraph A.(5)(c)(iii) hereof.

               (f)  "Conversion  Price" has the meaning  set forth in  Paragraph
A.(5)(a) hereof.

               (g) "Convertible  Securities" means any indebtedness or shares of
stock convertible into or exchangeable for Common Stock.


                                     - 16 -
<PAGE>


               (h)  "Dividend  Declaration  Date" means the last  trading day on
NASDAQ  immediately  prior to June 30 and  December 31 of each year in which any
shares of the Series D Preferred Stock are outstanding.

               (i) "Dividend Payment Dates" means July 31 and January 31 of each
year (or, if such day is not a business day, the next  succeeding  day that is a
business  day);  provided,  however,  that with  respect to July 31,  1999,  the
Dividend  Declaration  Date shall be the later to occur of (i) July 31, 1999, or
(ii) the date on which the Corporation's  registration statement with respect to
the Common Stock with which dividends are then to be paid is declared  effective
by the Securities and Exchange Commission.

               (j)  "Dividend  Period"  means the Initial  Dividend  Period and,
thereafter, each Semi-Annual Dividend Period.

               (k)  "Effective  Price" of shares of  Additional  Stock means the
quotient  determined  by  dividing  (i)  the  total  number  of such  shares  of
Additional  Stock issued or sold,  or deemed to have been issued or sold, by the
Corporation  under  Paragraph  A.(5)(c)  hereof,  into  (ii)  the  consideration
received by the Corporation under Paragraph  A.(5)(c) hereof for the issuance of
such shares of Additional Stock.

               (l)  "Initial   Dividend   Period"  means  the  dividend   period
commencing on the date of issuance of the Series D Preferred Stock and ending on
the first Dividend Payment Date to occur thereafter.

               (m) "Investor" means OCM Principal Opportunities Fund, L.P.

               (n)  "Intellectual  Property"  has the  meaning  set forth in the
Stock Purchase Agreement.

               (o) "Junior  Payment Date" has the meaning set forth in Paragraph
A.(3)(i) hereof.

               (p) "Junior  Securities"  has the meaning set forth in  Paragraph
A.(2) hereof.

               (q) "Material  Adverse  Effect" shall mean (i) any adverse change
in  the  condition   (financial  or  otherwise),   assets  (including,   without
limitation, patents and licenses to patents), liabilities,  business, results of
operations  or  prospects  of  the  Company  or  its  Subsidiary,  which  change
individually or in the aggregate,  is material to the Company or its Subsidiary,
or (ii) any event, matter,  condition or effect which impairs the ability of the
Company  or  its  Subsidiary  to  perform  on a  timely  basis  its  obligations
hereunder.  Materiality  under clauses (i) or (ii) hereof shall be determined in
good  faith by the  holders  of record of a  majority  of the shares of Series D
Preferred Stock.

               (r) "NASDAQ" shall have the meaning set forth in Paragraph A.3(a)
hereof.

               (s) "NYSE" shall mean the New York Stock Exchange.


                                     - 17 -
<PAGE>


               (t) "Option" means rights,  options or warrants to subscribe for,
purchase or otherwise acquire Common Stock or Convertible Securities.

               (u)  "Purchaser"  and  "Purchasers"  shall  mean  those  persons,
individually  and  collectively,  other than  Investor the  Corporation  who are
parties to the Stock Purchase Agreement, as identified on Exhibit D to the Stock
Purchase Agreement.

               (v)  "Permitted  Options"  has the meaning set forth in Paragraph
A.(5)(c)(ii)(B) hereof.

               (w) "Semi-Annual  Dividend Periods" means the semi-annual periods
(1)  commencing on each January 1 and ending on each June 30 and (2)  commencing
on July 1 and ending on each December 31.

               (x)  "Stockholders  and Registration  Rights Agreement" means the
Stockholders  and  Registration  Rights  Agreement  dated as of March 19,  1999,
between the  Corporation,  the Investor and the Purchasers  named  therein,  the
Schedules and Exhibits  thereto,  and any certificate or other document required
thereby, as the same may be amended from time to time.

               (y) "Stock Purchase Agreement" means the Stock Purchase Agreement
dated as of March 19, 1999, between the Corporation, Investor and the Purchasers
named therein,  the Schedules and Exhibits thereto, and any certificate or other
document required thereby, as the same may be amended from time to time.

          IN WITNESS WHEREOF,  the undersigned has caused this Certificate to be
signed on the 11th day of May, 1999.



                                          /s/ Brian M. Gallagher
                                          ------------------------------
                                          Brian M. Gallagher
                                          President and Chief Executive Officer











                                     - 18 -
<PAGE>


                                    EXHIBIT A

      Example of Application of Formula for Adjustment of Conversion Price.

          If,  twelve (12) months  after the  original  issuance of the Series D
Preferred Stock,  9,000,000 shares of Common Stock were then outstanding and the
Company were to issue 100,000 shares of Common Stock (the Additional  Stock) for
$10.00  per share  (and thus,  less than the $11  Conversion  Price for Series D
Preferred  Stock than in  effect),  the  Conversion  Price  would be adjusted as
follows:


                               [(A+B)] / [(C +D)]

[(9,000,000 x $11) + (100,000 x $10)] /  [(9,000,000) +(100,000)]

         [(99,000,000)+($1,000,000 )] /  [(9,100,000)]

                      [(100,000,000)] /  [(9,100,000)]

                                     = $10.99
















                                  Exhibit 10.2

                  Stockholders & Registration Rights Agreement


<PAGE>











                 STOCKHOLDERS AND REGISTRATION RIGHTS AGREEMENT

                                  BY AND AMONG

                        COLLAGENEX PHARMACEUTICALS, INC.,

                     OCM PRINCIPAL OPPORTUNITIES FUND, L.P.,

                                       AND

                           THE PURCHASERS NAMED HEREIN

                           Dated as of March 19, 1999





<PAGE>


                                TABLE OF CONTENTS


                                                                           Page


SECTION 1.     Definitions...................................................2

SECTION 2.     Covenants Not Surviving Conversion............................6

SECTION 3.     Covenants Surviving Conversion................................9

SECTION 4.     Right of First Refusal.......................................11

SECTION 5.     Registration Rights..........................................13

SECTION 6.     Duration of Agreement........................................27

SECTION 7.     Severability; Governing Law..................................27

SECTION 8.     Benefits of Agreement........................................27

SECTION 9.     Notices......................................................28

SECTION 10.    Changes......................................................29

SECTION 11.    Captions.....................................................29

SECTION 12.    Nouns and Pronouns...........................................29

SECTION 13.    Merger Provision.............................................29

SECTION 14.    Counterparts.................................................29

SCHEDULE I...................................................................3

EXHIBIT A....................................................................4

EXHIBIT B....................................................................6

EXHIBIT C....................................................................7






                                      -i-
<PAGE>


                 STOCKHOLDERS AND REGISTRATION RIGHTS AGREEMENT


            THIS   STOCKHOLDERS   AND   REGISTRATION   RIGHTS   AGREEMENT  (this
"Agreement")  made as of this 19th day of March,  1999, by and among  CollaGenex
Pharmaceuticals,  Inc., a Delaware corporation (the  "Corporation"),  having its
principal office at 301 South State Street, Newtown,  Pennsylvania 18940 and OCM
Principal  Opportunities Fund, L.P., a Delaware limited partnership,  having its
principal office at c/o Oaktree Capital Management, LLC, 333 South Grand Avenue,
28th Floor,  Los Angeles,  California  90071 (the  "Investor"),  and the persons
named  on  Exhibit  A  to  this  Agreement   (individually   a  "Purchaser"  and
collectively the "Purchasers").

                                   BACKGROUND

            The  Corporation is a corporation  duly organized and existing under
the  laws  of the  State  of  Delaware  with  an  authorized  capitalization  of
30,000,000  shares  of which  (a)  200,000  shares  are  designated  as Series D
Preferred  Stock,  par value $.01 per share,  all of which shares are issued and
outstanding as of this date; and (b) 25,000,000  shares are designated as Common
Stock,  par value $.01 per share,  of which (i) 8,587,204  shares are issued and
outstanding  as of this  date,  (ii)  1,818,182  shares  are duly  reserved  for
issuance in connection  with the conversion of Series D Preferred  Stock,  (iii)
458,182 shares are duly reserved for issuance in connection  with the payment of
dividends  in Common  Stock on  shares of the  Series D  Preferred  Stock;  (iv)
291,000  shares are duly  reserved  for  issuance to  directors,  employees  and
consultants of the Corporation in connection with the  Corporation's  1992 Stock
Option Plan, (v) 1,500,000 shares (subject to  stockholders'  approval) are duly
reserved  for  issuance to  employees  and  consultants  of the  Corporation  in
connection  with the  Corporation's  1996 Stock Option Plan, (vi) 300,000 shares
are reserved  for issuance to  non-employee  directors  under the  Corporation's
Non-Employee Director Stock Option Plan and (vii) 11,000 shares are reserved for
issuance pursuant to options granted outside any plan.

            Investor and each Purchaser owns (or will own in connection with the
Closing of the Stock Purchase Agreement, as defined below) that number of shares
of Common Stock and Series D Preferred  Stock (together with any other shares of
capital stock of the  Corporation  now owned or hereafter  acquired by Investor,
each  Purchaser,  and their  successors or assigns from any person by any means,
including  without  limitation,  any  acquisition by gift,  purchase,  dividend,
conversion, stock split,  recapitalization or otherwise at or before the Closing
Date,  collectively,  the "Shares") set forth  opposite the name of Investor and
each such  Purchaser  on Schedule I attached  hereto.  It is deemed to be in the
best interest of the Corporation,  Investor and each Purchaser that provision be
made for the  continuity  and  stability  of the  business  and  policies of the
Corporation  and, to that end, the Corporation,  Investor and Purchasers  hereby
set forth their agreement with respect to the Shares.

            Simultaneous with the execution and delivery of this Agreement,  the
Corporation  is entering into a Loan Agreement (as defined below) with Investor,
pursuant  to which  Investor


<PAGE>


will lend ten million  dollars to the  Corporation  evidenced by the Convertible
Note (as defined below). In the event that the sale and purchase of the Series D
Preferred  Stock are not  consummated  as  contemplated  in the  Stock  Purchase
Agreement,  Investor at its option,  will be entitled to convert the Convertible
Note into shares of the Corporation's  Common Stock in accordance with the terms
and conditions of the Convertible Note.

            NOW,  THEREFORE,  in consideration of the premises and of the mutual
consents  and  obligations  hereinafter  set forth,  the parties  hereto  hereby
further agree as follows:


            SECTION 1. DEFINITIONS. All capitalized terms used in this Agreement
shall have the  meanings  assigned to them  elsewhere  in this  Agreement  or as
specified below:

            "Affiliate"  of a person  shall mean (i) a person  that  directly or
indirectly, through one or more intermediaries, controls, is controlled by or is
under common control with, the first mentioned person,  and (ii) "an associate",
as the term is defined in Rule 12b-2  promulgated  under the  Exchange Act as in
effect as of the date of this Agreement.

            "Certificate of Designation" shall have the meaning set forth in the
Stock Purchase  Agreement.  A copy of the Certificate of Designation is attached
hereto as Exhibit C.

            "Certificate of Incorporation" shall mean the Corporation's  Amended
and Restated Certificate of Incorporation,  filed in the Office of the Secretary
of State of the State of Delaware on April 10, 1996,  as amended to date, a copy
of which is attached hereto as Exhibit B.

            "Closing"  shall mean the closing of the  transactions  contemplated
under the Stock  Purchase  Agreement,  which  shall take place at the offices of
Dechert  Price  &  Rhoads,   4000  Bell  Atlantic   Tower,   1717  Arch  Street,
Philadelphia,  Pennsylvania 19103-2793 on or before June 30, 1999, or such other
time as shall be mutually agreed upon by the parties hereto in writing.

            "Closing  Date" shall mean the date on which the  Closing  under the
Stock Purchase Agreement occurs.

            "Commission"  shall mean the United States  Securities  and Exchange
Commission.

            "Common Stock" shall mean (a) the  Corporation's  Common Stock,  par
value $.01 per share, as authorized on the date of this Agreement, (b) any other
capital stock of any class or classes  (however  designated) of the Corporation,
authorized  on or after the date  hereof,  the  holders of which  shall have the
right,  without  limitation  as to  amount,  either  to all or to a share of the
balance of current dividends and liquidating  distributions after the payment of
dividends  and  distributions  on any shares  entitled to  preference  under the
Certificate of Incorporation (as the same may be amended from time to time after
the Closing),  and (c) any other  securities  into which or for which any of the
securities described in clause (a) or (b) of this definition may be converted or
exchanged pursuant to a plan of recapitalization,  reorganization,  merger, sale
of assets or otherwise.


                                     - 2 -
<PAGE>


            "Conversion Price" shall mean, with respect to the conversion of the
Series D Preferred Stock to Common Stock,  Eleven Dollars ($11.00) per share, as
of the date of execution of this Agreement, subject to adjustment as provided in
the Certificate of Designation.

            "Convertible  Note"  shall mean the 12% Senior  Secured  Convertible
Note due March 18, 2000 issued by the Corporation,  dated as of the date hereof,
in favor of Investor.

            "Default  Dividends"  shall  have  the  meaning  set  forth  in  the
Certificate of Designation.

            "Documents" shall mean this Agreement, the Stock Purchase Agreement,
the Certificate of Designation, the Loan Agreement and the Convertible Note.

            "Employee  Benefit  Plan"  shall have the  meaning  set forth in the
Stock Purchase Agreement.

            "ERISA"  shall  have the  meaning  set forth in the  Stock  Purchase
Agreement.

            "Event  of  Default"  shall  have  the  meaning  set  forth  in  the
Certificate of Designation.

            "Equity Securities" shall have the meaning set forth in Section 4(a)
hereof.

            "Exchange  Act" shall mean the  Securities  Exchange Act of 1934, as
amended, and the rules and regulations of the Commission promulgated thereunder,
all as the same shall be in effect at the time.

            "Exchange  Act  Registration  Statement"  shall mean a  registration
statement  filed  pursuant to the Exchange Act,  relating to any class of equity
securities of the Corporation.

            "Excluded  Form" shall mean a registration  statement filed pursuant
to the Securities Act on Form S-8, S-4 or any similar or successor forms.

            "Excluded  Securities"  shall mean  those  securities  described  in
Section 4(g) hereof.

            "Form S-3" shall  mean the form  under the  Securities  Act as is in
effect  on the  date  hereof  or any  successor  registration  forms  under  the
Securities Act subsequently  adopted by the Commission which permit inclusion or
incorporation  of substantial  information by reference to other documents filed
by the Corporation with the Commission.

            "Holder" shall mean any holder of Series D Preferred Stock owning of
record  Registrable  Securities  that have not been sold to the public and,  for
purposes of this  Agreement,  a record  holder of the Series D  Preferred  Stock
convertible into such Registrable Securities shall be deemed to be the Holder of
such Registrable Securities; provided, however, that the Corporation shall in no
event be obligated to register the Series D Preferred Stock, and that Holders of


                                     - 3 -
<PAGE>



Registrable Securities shall not be required to convert their shares of Series D
Preferred Stock into Common Stock in order to exercise the  registration  rights
granted under Section 6 hereof,  until  immediately  before the effectiveness of
the offering to which the registration relates.

            "Initiating  Holders"  shall have the  meaning  set forth in Section
5(c)(ii) hereof.

            "Investor Notice of Acceptance"  shall have the meaning set forth in
Section 4(c) hereof.

            "Loan  Agreement"  shall  mean the  Convertible  Loan  and  Security
Agreement,  dated as of the date  hereof,  by and  between the  Corporation,  as
borrower, and Investor, as lender, under such agreement.

            "Material  Adverse  Effect" shall mean (i) any adverse change in the
condition  (financial  or  otherwise),  assets  (including  without  limitation,
patents and licenses to patents),  liabilities,  business, results of operations
or prospects of the Corporation and its subsidiary,  which change,  individually
or in the aggregate,  is material to the Corporation or its subsidiary,  or (ii)
any  event,  matter,  condition  or effect  which  impairs  the  ability  of the
Corporation or its subsidiary to perform on a timely basis its obligations under
this  Agreement  or the Stock  Purchase  Agreement  or the  consummation  of the
transactions  contemplated  by this Agreement and the Stock Purchase  Agreement.
Materiality  under  clauses (i) or (ii) hereof  shall be as  determined  in good
faith by Investor.

            "NASDAQ" shall mean the NASDAQ National Market.

            "Note  Conversion  Price" shall mean, with respect to the conversion
of the Convertible  Note to Common Stock, the Note Conversion Price specified in
the  Convertible  Note, as the same may be adjusted in accordance with the terms
thereof.

            "NYSE" shall mean the New York Stock Exchange.

            "Person"  shall mean and include an  individual,  a  corporation,  a
partnership,  a trust, an  unincorporated  organization  and a government or any
department, agency or political subdivision thereof.

            "Register",   "registered"  and  "registration"  shall  refer  to  a
registration  effected  by  preparing  and filing a  registration  statement  in
compliance  with  the  Securities  Act,  and  the  declaration  or  ordering  of
effectiveness of such registration statement.

            "Registrable  Securities"  shall mean:  (a) all the shares of Common
Stock of the Corporation issued or issuable upon the conversion of the shares of
Series D Preferred  Stock that are now owned or may hereafter be acquired by any
Holder or its permitted  successors and assigns,  all the shares of Common Stock
of the  Corporation  issued or issuable upon the  conversion of the  Convertible
Note that are now owned or  hereafter  acquired  by  Investor  or its


                                     - 4 -
<PAGE>


permitted  successors  and assigns and any other shares of Common Stock acquired
by such Holder  pursuant to Section 4 of this  Agreement;  and (b) any shares of
Common Stock of the  Corporation  issued as (or issuable upon the  conversion or
exercise of any warrant,  right or other security which is issued as) a dividend
or other  distribution  with respect to, or in exchange for or in replacement of
all such  shares of Common  Stock  described  in clause (a) of this  definition;
excluding in all cases, however, (i) any Registrable Securities sold pursuant to
registration  under the Securities Act or (ii) any Registrable  Securities sold,
subsequent to the Corporation's initial public offering of securities registered
under the Securities  Act,  pursuant to Rule 144 (or similar or successor  rule)
promulgated under the Securities Act.

            "Registrable  Securities then outstanding"  shall mean the number of
shares of  Registrable  Securities  that are then issued and  outstanding or are
then issuable  pursuant to the exercise or conversion  of then  outstanding  and
then exercisable options, warrants or convertible securities.

            "Registration  Expenses" shall have the meaning set forth in Section
5(d) hereof.

            "Remaining  Securities"  shall have the meaning set forth in Section
4(d) hereof.

            "Securities  Act" shall mean the Securities Act of 1933, as amended,
and the rules and regulations of the Commission promulgated  thereunder,  all as
the same shall be in effect at the time.

            "Series D Preferred Stock Director" shall have the meaning set forth
in the Certificate of Designation.

            "Series D Preferred Stock" shall mean the  Corporation's  authorized
200,000  shares of Series D  Convertible  Preferred  Stock,  par value  $.01 per
share,  having  the  designations,   rights,   preferences  and  privileges  and
qualifications, limitations and restrictions of preferred stock set forth in the
Certificate of Designation.

            "Shareholder   Protection   Rights   Agreement"   shall   mean  that
Shareholder Protection Rights Agreement dated September 15, 1997, by and between
the Corporation and the American Stock Transfer & Trust Company.

            "Subsidiary"  means any corporation with respect to which a majority
of the voting stock is owned directly or indirectly by the Corporation.

            "Stock Purchase  Agreement" shall mean the Stock Purchase  Agreement
dated as of the date  hereof,  by and among the  Corporation,  Investor  and the
Purchasers named therein, as the same may be amended from time to time.

            "Violation"  shall have the  meaning  set forth in  Section  5(h)(i)
hereof.


                                     - 5 -
<PAGE>



            SECTION 2. COVENANTS OF THE CORPORATION NOT SURVIVING CONVERSION. So
long as any  shares  of the  Series  D  Preferred  Stock  are  outstanding,  the
Corporation hereby covenants and agrees as follows:

            (a) Reserve for  Reserved  Shares.  The  Corporation  currently  has
reserved an aggregate of (i) Two Million Two Hundred Seventy-Six  Thousand Three
Hundred  Sixty-Four  (2,276,364) shares of its authorized but unissued shares of
Common Stock for purposes of effecting the  conversion of the shares of Series D
Preferred  Stock and paying  Investor and  Purchasers  dividends in Common Stock
during the three (3) years  immediately  following the date of original issuance
of Series D Preferred  Stock;  and (ii) One Million  Five  Hundred  Thirty-Eight
Thousand  Four  Hundred  Sixty-Two  (1,538,462)  shares  of its  authorized  but
unissued   Common  Stock  for  purposes  of  effecting  the  conversion  of  the
Convertible  Note. The Corporation  shall at all times take appropriate steps to
reserve and keep available out of its  authorized but unissued  shares of Common
Stock,  for the purpose of effecting  the  conversion  of the shares of Series D
Preferred Stock, paying Investor and Purchasers dividends in Common Stock during
the three (3) years  following  the date of  original  issuance  of the Series D
Preferred  Stock  and  paying  Default  Dividends  in  respect  to the  Series D
Preferred  Stock  in  accordance  with  the  Certificate  of  Designation,   the
conversion of the  Convertible  Note and otherwise  complying  with the terms of
this  Agreement,  such  additional  number of its duly  authorized  but unissued
shares of Common Stock as shall be  sufficient  to effect the  conversion of the
shares of Series D Preferred Stock from time to time outstanding, the conversion
of the Convertible Note or otherwise to comply with the terms of this Agreement.
If at any time the number of  authorized  but  unissued  shares of Common  Stock
shall not be  sufficient  to effect  the  conversion  of the  shares of Series D
Preferred  Stock,  the conversion of the Convertible Note or otherwise to comply
with the terms of this  Agreement,  the  Corporation  shall  forthwith take such
corporate  action as may be necessary to increase  its  authorized  but unissued
shares of Common Stock to such number of shares as shall be sufficient  for such
purposes. The Corporation shall obtain any authorization,  consent,  approval or
other  action by or make any filing with any court or  administrative  body that
may be required under  applicable  state  securities laws in connection with the
issuance  of shares of Common  Stock upon  conversion  of the shares of Series D
Preferred Stock or upon conversion of the Convertible Note.

            (b) Financial  Reports.  The Corporation shall furnish Investor with
the following:

                 (i) Monthly  Reports.  As soon as practicable,  and in any case
within  thirty (30)  calendar  days after the end of each  calendar  month,  the
Corporation  shall  furnish each holder of twenty  percent  (20%) or more of the
Series D Preferred  Stock then  outstanding  with  monthly  unaudited  financial
statements  (all  prepared in  accordance  with  generally  accepted  accounting
principles consistently applied), including (A) an unaudited balance sheet as of
the last day of such month, (B) an unaudited statement of income for such month,
together  with a  cumulative  statement of income from the first day of the then
current fiscal year to the last day of such month, (C) a cash flow statement for
such month,  together with a cash flow  statement from the first day of the then
current fiscal year to the last day of such month, (D) a schedule showing

                                     - 6 -
<PAGE>


all  prescription  data on new and  existing  users,  (E) an aging  schedule (or
summary  thereof) of all accounts  receivable  and accounts  payable,  and (F) a
comparison  between the actual figures for such month,  the  comparable  figures
(with  respect to clauses  (A),  (B) and (C) only) for the prior year period and
the  comparable  figures in the  Budget.  For the  purposes  of this  Agreement,
"Budget" shall mean the  Corporation's  annual operating and capital budget with
monthly  breakdowns  prepared by  management  and signed by the President or the
Chief Financial Officer of the Corporation.  The foregoing financial  statements
shall  be  certified  by  the  President  or  Chief  Financial  Officer  of  the
Corporation  to the effect that such  statements  fairly  present the  financial
position and financial results of the Corporation for the fiscal period covered,
and  shall  be  accompanied  by  a  written  explanation  of  (A)  any  material
differences  between the operating and financial results and the Budget,  (B) an
analysis  of  any  significant  problems,   changes,  events  and  achievements,
including without limitation, those involving sales and marketing activities and
staffing and (C) a commentary on developing  changes in the business  outlook of
the  Corporation,  together with a statement as to their  anticipated  effect on
future operations and previous forecasts.

                 (ii) Annual  Reports.  As soon as  practicable  and in any case
within ninety (90)  calendar  days after the end of each fiscal year  (beginning
with the fiscal year ending December 31, 1998),  the  Corporation  shall furnish
Investor  with a balance sheet as of the end of such fiscal year, a statement of
income and a statement of cash flows of the Corporation  for such year,  setting
forth in each  case in  comparative  form  the  figures  from the  Corporation's
previous  fiscal  year,  all  prepared in  accordance  with  generally  accepted
accounting principles  consistently applied and audited by independent auditors.
With the financial  statements referred to in Sections 2(b)(i),  the Corporation
shall  deliver to  Investor a  certificate  executed by the  President  or Chief
Financial Officer of the Corporation, and with the financial statements referred
to in Section  2(b)(ii),  there shall be delivered to Investor a certificate  of
the form of certified public accountants  auditing such financial  statements of
the Corporation, in each case, to the effect that no knowledge has been obtained
of any  violation  or  default  by the  Corporation  in the  performance  of its
agreements or covenants contained herein, in the Certificate of Incorporation or
in any other  material  agreement to which the  Corporation is a party or of the
occurrence of any condition, event or act which, with or without notice or lapse
of time, or both,  would  constitute a violation or an event of default,  or, if
such firm or  officer  shall  have  obtained  knowledge  of any such  violation,
condition,  event or act,  it or he (as the case may be) shall  specify  in such
certificate all such violations,  conditions, events and acts and the nature and
status thereof.

                 (iii) Budget and  Operating  Forecast.  For each fiscal year of
the  Corporation,  commencing  with the fiscal year ending  December  31,  1998,
within  thirty (30)  calendar  days before the last day of such fiscal year (and
with respect to the fiscal year ending  December 31, 1998, on or before the date
of Closing),  and at least thirty (30) calendar days before the last day of each
fiscal year thereafter,  management of the Corporation  shall prepare and submit
the Budget for the immediately succeeding fiscal year to the Board of Directors.
The Budget shall be accepted as the Budget for such fiscal year when it has been
approved  by a majority  vote of the Board of  Directors  (the  Budget  approval
process shall hereinafter be referred


                                     - 7 -
<PAGE>


to as the "Budget Vote").  The Corporation shall furnish Investor with a copy of
the approved  Budget no later than ten (10) business days after the Budget Vote.
The approved  Budget shall be reviewed by the Corporation  periodically  and all
necessary  changes or revisions to the Budget shall be  resubmitted to the Board
of Directors and shall be accepted when  approved in  accordance  with,  and the
Corporation  shall not make any such changes to, the Budget without  approval in
accordance with, the Budget Vote.

                 (iv)  Auditor's  Letters.  No later than five (5) business days
following  receipt by the  Corporation,  the Corporation  shall furnish Investor
with each  audit  response  letter,  accountant's  management  letter  and other
written  report   submitted  to  the  Corporation  by  its  independent   public
accountants  in  connection  with an annual or interim audit of the books of the
Corporation.

                 (v) Notice of  Actions.  No later than five (5)  business  days
after the  commencement  thereof,  the Corporation  shall furnish  Investor with
written notice of all actions,  suits, claims,  proceedings,  investigations and
that could have, individually or in the aggregate, a Material Adverse Effect.

                 (vi)  Other  Information.  Promptly,  from  time to  time,  the
Corporation  shall furnish  Investor with such other  information  regarding the
business, prospects, financial condition, operations, property or affairs of the
Corporation as Investor reasonably may request.

                 (vii)  Subsidiaries.  If for any period the  Corporation  shall
have any subsidiary or subsidiaries  whose accounts are consolidated  with those
of the  Corporation,  then in  respect of such  period,  the  Corporation  shall
furnish  Investor  with the  financial  statements,  letters,  notices and other
information  delivered  pursuant  to  the  foregoing  Sections  2(b)(i)  through
2(b)(vi) shall be the consolidated  financial  statements of the Corporation and
all  such  consolidated   subsidiaries  and  the  letters,   notices  and  other
information relating to the Corporation and all such subsidiaries, as well.

            (c) System of Accounting. The Corporation shall maintain a system of
accounting  established and  administered in accordance with generally  accepted
accounting principles consistently applied, and shall set aside on its books all
such  proper  reserves as shall be required  by  generally  accepted  accounting
principles consistently applied.

            (d) Related  Transactions.  The Corporation  shall not,  without the
approval by a majority vote of the Board of Directors (including the approval of
two (2) independent  directors),  directly or indirectly,  except for employment
arrangements with its officers, enter into any Related Transactions in excess of
the amount set forth in Item 404(a) of  Regulation  S-K of the  Exchange  Act in
effect as of the date hereof.  All such Related  Transactions shall be conducted
only on an arm's length basis and on terms no less favorable to the  Corporation
than could be obtained from non-related persons.


                                     - 8 -
<PAGE>


            (e) Rule 144. As set forth in Section 5(l) hereto,  the  Corporation
shall take all  necessary  action to comply  with the  requirements  of Rule 144
under the Securities Act.


            SECTION 3. COVENANTS OF THE CORPORATION SURVIVING CONVERSION. At all
times  from the date of this  Agreement  the  Corporation  hereby  agrees to the
following covenants:

            (a) NASDAQ Listing. The Corporation shall take all actions necessary
or appropriate  to ensure that the shares of stock  issuable upon  conversion of
the Series D Preferred  Stock or upon  conversion  of the  Convertible  Note are
listed  or  authorized  to be quoted  on the  NASDAQ  or listed on any  national
securities  exchange  on which  shares of  Common  Stock  are then  listed.  The
Corporation  will take all actions  necessary or  appropriate  to ensure that it
maintains a public market for its Common Stock on the American  Stock  Exchange,
NASDAQ or the NYSE. If the Common Stock of the  Corporation  ceases to be listed
or  authorized  to be quoted on any national  securities  exchange or the public
market for the Common Stock of the Corporation  otherwise  ceases to exist,  the
Corporation  shall  engage an  investment  bank,  reasonably  acceptable  to the
Corporation  and the holders of record of a majority of the shares of the Series
D  Preferred  Stock  then  outstanding  (or if  applicable,  the  Holder  of the
Convertible Note), to determine the fair market value price of the Common Stock,
from time to time in  connection  with  Paragraphs  A.3.,  A.5.  and A.6. of the
Certificate of  Designation,  or in connection with Section 3 of the Convertible
Note.

            (b) VCOC  Qualification.  So long as Investor owns any fully-diluted
voting stock of the  Corporation  (assuming  conversion  in full of the share of
Series D Preferred  Common Stock),  such  investment  shall qualify as a venture
capital operation company under applicable ERISA laws ("VCOC").  The Corporation
covenants and agrees Investor shall  therefore be entitled to meet  periodically
with the  management  of  Corporation  on a timely  basis to  discuss  financial
results, business prospects and other matters upon Investor's reasonable request
and that Investor or its  designated  representative  shall be afforded free and
full access,  at all reasonable  times, and with reasonable prior notice, to all
of the books,  records and  properties of the  Corporation  and to all officers,
employees and  accountants or auditors of the  Corporation and to make proposals
to the  Corporation,  the Board of Directors of the  Corporation  and/or  senior
management of the Corporation.

            (c) Representation of the Board of Directors.

                 (i) So long as the holders of record of a majority of shares of
Series D  Preferred  Stock  have the  right  to elect  one (1) or more  Series D
Preferred Stock Director (as set forth in the Certificate of Designation),  then
provided  that such  Series D  Preferred  Stock  Director(s)  is (or are) not an
employee of Investor,  the  Corporation  shall pay the Series D Preferred  Stock
Director a director's fee equal to the fees received by  non-employee  directors
of the  Corporation  and shall be entitled to receive the same  indemnification,
officers and  directors  insurance  coverage and other  protections  as are made
available by the Corporation to non-employee  directors of the  Corporation.  So
long as no Event of Default has  occurred or is


                                     - 9 -
<PAGE>


continuing, and so long as the proposed Series D Preferred Stock Director is not
an employee of  Investor,  the  Corporation  shall have the right to approve the
Series D Preferred  Stock Director  (which  approval  shall not be  unreasonably
withheld or delayed).  The  Corporation  shall  reimburse the Series D Preferred
Stock Director for all reasonable  out-of-pocket  expenses  associated  with all
activities related to the Series D Preferred Stock Director's duties as a member
of the Board of Directors  or any  committee  thereof.  The  Corporation  hereby
agrees to take any and all steps  necessary to effectuate  the rights granted to
the holders of record of Series D Preferred Stock set forth in Paragraph A.8.(c)
of the Certificate of Designation.

                 (ii) So long as Investor  owns ten percent  (10%) of the shares
of the fully  diluted  voting stock of the  Corporation  then  outstanding,  the
Corporation shall take such necessary action to ensure that Investor is entitled
to elect one (1) director to the Board of Directors of the Corporation.

            (d) Registration  Rights.  The Corporation  shall take all necessary
action to give effect to the registration rights set forth in Section 5 hereto.

            (e) Antitakeover Statute;  Shareholder  Protection Rights Agreement.
The Corporation  and its Board of Directors shall (i) take all action  necessary
to guarantee that no state takeover  statute or similar statute or regulation is
or becomes applicable to this Agreement or any of the transactions  contemplated
hereby and (ii) if any state takeover  statute or similar  statute or regulation
becomes  applicable to this  Agreement or any of the  transactions  contemplated
hereby,   take  all  action   necessary  to  guarantee  that  the   transactions
contemplated  by this Agreement may be consummated as promptly as practicable on
the terms contemplated by this Agreement and otherwise to minimize the effect of
such statute or regulation on the  transactions  contemplated by this Agreement.
The Corporation  and its Board of Directors  shall take all necessary  action to
guarantee  that no rights  distributed  pursuant to the  Shareholder  Protection
Rights Agreement become exercisable as a result of the transactions contemplated
by the Documents. The Corporation shall not take any action to create any new or
additional  rights  similar  to those  set forth in the  Shareholder  Protection
Rights Agreement, or in addition, any anti-takeover measures that could have the
effect of restricting the rights of Holders under the Documents.

            (f) Securities Filings.  The Corporation shall take all necessary or
appropriate  actions  requested by Investor to assist Investor in complying with
Investor's obligations to make

any and all securities filings under the Exchange Act, the Securities Act or the
applicable  state  securities  laws of any state required in connection with the
transactions contemplated herein.

            (g) Protective  Agreements.  The Corporation  shall, and shall cause
its Subsidiary to, enter into agreements  (substantially in the form utilized by
the  Corporation as of the date of execution of this Agreement) with all Persons
with  whom the  Corporation  or its  Subsidiary  plans  to  share,  disclose  or
otherwise  make  available  its  Confidential  Information  (as  defined  below)
pursuant  to which such  Persons  will be bound  contractually  to protect  from
disclosure  and keep  confidential  such the  Corporation'  or its  subsidiary's
Confidential  Information


                                     - 10 -
<PAGE>


and not to use any such  Confidential  Information for any purpose other than as
may be  specifically  provided in such  agreement.  For purposes of this Section
3(g) "Confidential Information" shall mean the Corporation's or its Subsidiary's
trade secrets,  business plans, technology,  procedures,  manuals,  confidential
reports and  communications,  lists of  potential  customers  and  clients,  any
information  and materials  received by the  Corporation or its Subsidiary  from
third parties in confidence (or subject to non-disclosure or similar covenants),
production  processes,  product designs,  marketing techniques and arrangements,
mailing lists,  purchasing  information,  pricing policies,  quoting procedures,
non-public financial information,  customer and prospect names and requirements,
employee,  customer,  supplier  and  distributor  data and  other  materials  or
information  relating to the  Corporation's  or its  Subsidiary's  business  and
activities  and the  manner  in which the  Corporation  or its  Subsidiary  does
business,  discoveries,  concepts, and ideas, including, without limitation, the
nature and results of research and development activities,  processes, formulas,
inventions,  techniques  and  "know-how,"  any other  materials  or  information
related to the business or  activities  of the  Corporation  or its  Subsidiary,
which are not  generally  known to  others  engaged  in  similar  businesses  or
activities  and all ideas which are derived from or relate to the  Corporation's
or  its  Subsidiary's  access  to  any  of the  above  mentioned  materials  and
information.


            SECTION 4. RIGHT OF FIRST REFUSAL. Investor shall be entitled to the
following right of first refusal:

            (a) Except in the case of Excluded Securities, in the event that the
Corporation,  after the initial  twelve (12) months from the date of issuance of
the Series D Preferred Stock, issues, sells or exchanges,  agrees to issue, sell
or exchange, or reserves or sets aside for issuance,  sale or exchange,  (i) any
shares of Common Stock, (ii) any other equity security of the Corporation, (iii)
any debt security of the Corporation  which by its terms is convertible  into or
exchangeable  for,  with or without  consideration,  any equity  security of the
Corporation,  (iv) any security of the Corporation that is a combination of debt
and equity or (v) any option,  warrant or other right to subscribe for, purchase
or  otherwise  acquire  any equity  security  or any such debt  security  of the
Corporation  (collectively,  the  "Equity  Securities"),  at a  price  or with a
conversion  price  below the  Conversion  Price while any shares of the Series D
Preferred  Stock are outstanding  (or, at any time that the Convertible  Note is
outstanding  or shares of Common Stock are  outstanding  upon  conversion of the
Convertible Note, at a price per share less than the Note Conversion Price), the
Corporation  shall  first  offer to sell to Investor  the

Equity  Securities  by giving  Investor  Written  Notice  thereof  delivered  to
Investor  (the  "Offer"),  which  Offer  by its  terms  shall  remain  open  and
irrevocable for a period of twenty (20) business days from the date the Offer is
received by Investor.

            (b)  Investor  shall  have the  right,  but not the  obligation,  to
purchase any or all of the Equity  Securities  on the same terms as specified in
the Offer to purchase the Equity Securities.


                                     - 11 -
<PAGE>


            (c) Notice of Investor's  intention to accept,  in whole or in part,
an Offer shall be evidenced by a writing signed by Investor and delivered to the
Corporation  at or prior  to the end of the  twenty  (20)  business  day  period
commencing with the date the Offer is received by Investor (or, if later, within
ten (10)  calendar  days  after the giving of any  written  notice of a material
change in such Offer),  setting forth such portion (specifying number of shares,
principal amount or the like) of the Equity Securities as the Investor elects to
purchase (the "Investor Notice of Acceptance").

            (d) The  Corporation  shall have ninety (90)  calendar days from the
expiration of the  foregoing  twenty (20) business day period to sell all or any
part of such Equity  Securities as to which an Investor Notice of Acceptance has
not been given by Investor (the  "Remaining  Securities") to any other person or
persons, but only upon terms and conditions in all material respects,  including
without  limitation,  unit price and interest  rates (but  excluding  payment of
legal fees of counsel of the  purchaser),  which are no more  favorable,  in the
aggregate, to such other person or persons or less favorable to Corporation than
those set forth in the Offer.  Upon the closing of the sale to such other person
or persons of all the Remaining  Securities,  which shall include payment of the
purchase price to the  Corporation in accordance with the terms of the Offer, if
Investor has timely  submitted an Investor Notice of Acceptance,  Investor shall
purchase from the Corporation,  and the Corporation shall sell to Investor,  the
Equity  Securities  in respect of which an  Investor  Notice of  Acceptance  was
delivered to the  Corporation by Investor,  at the terms specified in the Offer.
The purchase by Investor of any Equity Securities is subject in all cases to the
preparation, execution and delivery by the Corporation and Investor of customary
documentation  relating to such Equity Securities as is satisfactory in form and
substance to Investor and its counsel.

            (e) In each case, any Equity Securities not purchased by Investor or
by a person  or  persons  in  accordance  with  Section  4(d) may not be sold or
otherwise  disposed  of until  they are  again  offered  to  Investor  under the
procedures specified in Sections 4(a), (b), (c), and (d) hereof.

            (f) The  Corporation  hereby agrees that on or prior to the issuance
to any person of any Equity Securities not purchased by Investor hereunder,  but
excluding  issuances made pursuant to a public offering,  the Corporation  shall
cause  such  person to  acknowledge  in  writing  Investor's  rights  under this
Agreement.

            (g) The rights of Investor  under this  Section 4 shall not apply to
the following securities (the "Excluded Securities"):

                 (i) Common Stock or options to purchase shares of Common Stock,
issued  to  officers,   employees  or  directors  of,  or  consultants  to,  the
Corporation, pursuant to the 1992 Stock Option Plan, the 1996 Stock Option Plan,
the  Non-Employee  Director  Stock  Option  Plan or any other plan  subsequently
approved by the  Corporation;  provided,  however,  that the  maximum  number of
shares of Common Stock  heretofore or hereafter  issued or issuable  pursuant


                                     - 12 -
<PAGE>


to all such agreements, plans and arrangements shall not exceed an aggregate (as
constituted  on  the  date  hereof)  Two  Million  Three  Hundred  Two  Thousand
(2,302,000) shares of Common Stock;

                 (ii) Common Stock issued as a stock  dividend or upon any stock
split or other subdivision or combination of shares of Common Stock;

                 (iii)  Common  Stock  issued upon  conversion  of any shares of
Series D Preferred Stock; and

                 (iv) any securities  issued for  consideration  other than cash
pursuant  to  a  merger,   consolidation,   acquisition   or  similar   business
combination.


            SECTION 5. REGISTRATION RIGHTS.

            (a) Restrictive  Legend. Each certificate for the Series D Preferred
Stock  and  each  certificate  for any  such  securities  issued  to  subsequent
transferees of any such certificate shall be stamped or otherwise imprinted with
the following legend and shall not be transferable  except in compliance with or
a valid exception from the Securities Act and applicable state "blue sky" laws:

            "THE SECURITIES  REPRESENTED BY THIS  CERTIFICATE HAVE BEEN ACQUIRED
FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED,  OR ANY APPLICABLE  STATE  SECURITIES LAW. THESE  SECURITIES MAY NOT BE
SOLD  OR  TRANSFERRED  IN THE  ABSENCE  OF  SUCH  REGISTRATION  OR AN  EXEMPTION
THEREFROM UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW."

            (b) Shelf Registration.

                 (i)  The  Corporation   shall,  at  its  cost,  file  with  the
Commission  and  thereafter  shall use its best  efforts to cause to be declared
effective,  not later than 150 days after Closing, a registration statement (the
"Shelf Registration Statement"), on a Form S-3 or any successor form thereto, if
the Company is then eligible,  or in connection with the Convertible  Note in no
event later than one hundred  fifty (150) days after the Date of  Conversion  of
the  Convertible  Note,  on a Form S-3 or any  successor  form  thereto,  if the
Company is then eligible, relating to the offer and sale of the shares of Common
Stock  issuable upon  conversion  of the shares of Series D Preferred  Stock and
Common Stock issuable in respect of any dividends  described in the  Certificate
of  Designation  on the shares of Series D Preferred  Stock as well as shares of
Common Stock issuable upon conversion of the Convertible Note (the "Securities")
by the  Holders  thereof  from time to time in  accordance  with the  methods of
distribution  set forth in the Shelf  Registration  Statement and Rule 415 under
the Securities Act (hereinafter,  the "Shelf Registration");  provided, however,
that no Holder of  Securities  (other than Investor or any  Purchaser)  shall be
entitled to have the Securities covered by such Shelf  Registration  Statement


                                     - 13 -
<PAGE>


unless  such  Holder  of  Securities  agrees in  writing  to be bound by all the
provisions of this Agreement applicable to such Holder of Securities.

                 (ii) The  Corporation  shall use its best  efforts  to keep the
Shelf  Registration  Statement  continuously  effective  in order to permit  the
prospectus  included  therein  to  be  lawfully  delivered  by  the  Holders  of
Securities  until the  expiration  of the  holding  period  with  respect to the
Securities set forth in clause (k) of Rule 144 promulgated  under the Securities
Act or such shorter period that will terminate when all the shares of Securities
covered by the Shelf Registration Statement have been sold pursuant thereto. The
Corporation  shall be deemed not to have used its best efforts to keep the Shelf
Registration  Statement  effective during the requisite period if it voluntarily
takes any action that would result in Holders of the Securities  covered thereby
not being able to offer and sell such Securities during that period, unless such
action is required by applicable law. (iii).Notwithstanding any other provisions
of this  Agreement  to the  contrary,  the  Corporation  shall  cause  the Shelf
Registration   Statement  and  the  related  prospectus  and  any  amendment  or
supplement  thereto,  as  of  the  effective  date  of  the  Shelf  Registration
Statement,  amendment or supplement, (i) to comply in all material respects with
the applicable  requirements of the Securities Act and the rules and regulations
of the  Commission  and (ii) not to contain any untrue  statement  of a material
fact or omit to state a material fact required to be stated therein or necessary
in order to make the statements  therein,  in light of the  circumstances  under
which they were made, not misleading.

            (c) Shelf  Registration  Procedures.  In  connection  with any Shelf
Registration contemplated by Section 5(b) hereof, the following provisions shall
apply:

                 (i)  The  Corporation  shall  (A)  furnish  to  Investor,  each
Purchaser,  and each Holder of Securities  prior to the filing  thereof with the
Commission,  a copy of the  Shelf  Registration  Statement  and  each  amendment
thereof and each supplement,  if any, to the prospectus included therein and, in
the  event  that  Investor,  any  Purchaser  or  any  Holder  of  Securities  is
participating in the Shelf Registration Statement, shall use its best efforts to
reflect in each such document, when so filed with the Commission,  such comments
as such Investor,  Purchaser or any Holder of Securities reasonably may propose;
and (B)  include  the names of the  Holders of  Securities  who  propose to sell
Securities  pursuant to the Shelf  Registration  Statement  as selling  security
holders.

                 (ii) The  Corporation  shall advise (and confirm such advice in
writing if requested by the recipient of the advice) Investor, Purchaser and the
Holders of Securities:

                    (A) when the Shelf  Registration  Statement or any amendment
thereto  has been  filed  with the  Commission  and when the Shelf  Registration
Statement or any post-effective amendment thereto has become effective;


                                     - 14 -
<PAGE>


                    (B) of any  request  by the  Commission  for  amendments  or
supplements  to the Shelf  Registration  Statement  or the  prospectus  included
therein or for additional information;

                    (C) of the  issuance  by the  Commission  of any stop  order
suspending  the  effectiveness  of  the  Shelf  Registration  Statement  or  the
initiation of any proceedings for that purpose;

                    (D) of the receipt of the  Corporation  or its legal counsel
of any notification  with respect to the suspension of the  qualification of the
Securities for sale in any  jurisdiction or the initiation or threatening of any
proceeding for such purpose; and

                    (E)  of  the  happening  of  any  event  that  requires  the
Corporation  to  make  changes  in  the  Shelf  Registration  Statement  or  the
prospectus in order that the Shelf Registration Statement or the prospectus does
not contain an untrue  statement of a material fact nor omit to state a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading.

                 (iii) The Corporation  shall use its best efforts to obtain the
withdrawal  at  the  earliest   possible  time  of  any  order   suspending  the
effectiveness of the Shelf Registration Statement.

                 (iv) The Corporation shall furnish to each Holder of Securities
included within the coverage of the Shelf Registration, without charge, at least
one copy of the Shelf Registration  Statement and any  post-effective  amendment
thereto,  including  financial  statements and schedules,  and, if the Holder of
Securities so requests in writing,  all exhibits  thereto  (including  those, if
any, incorporated by reference).

                 (v) The Corporation  shall deliver to each Holder of Securities
included within the coverage of the Shelf Registration,  without charge, as many
copies of the prospectus (including each preliminary prospectus) included in the
Shelf  Registration  Statement and any  amendment or supplement  thereto as such
person  may  reasonably  request.  The  Corporation  consents,  subject  to  the
provisions of this  Agreement,  to the use of the prospectus or any amendment or
supplement thereto included in the Shelf  Registration  Statement by each of the
selling  Holders of the  Securities in connection  with the offering and sale of
the Securities covered by such prospectus or any such amendment or supplement.

                 (vi) Prior to any public  offering of the shares of Securities,
pursuant to any Shelf Registration Statement,  the Corporation shall register or
qualify or cooperate with the Holders of Securities  included  therein and their
respective  counsel in connection with the  registration or qualification of the
Securities  for offer and sale under the  securities  or "blue sky" laws of such
states of the United  States as any Holder of  Securities  covered by such Shelf
Registration  Statement;  provided,  however,  that the Corporation shall not be
required to (A) qualify generally to do business in any jurisdiction where it is
not then so qualified  or (B) take any


                                     - 15 -
<PAGE>


action  which would  subject it to general  service of process or to taxation in
any jurisdiction where it is not then so subject.

                 (vii) The  Corporation  shall  cooperate  with the  Holders  of
Securities to facilitate  the timely  preparation  and delivery of  certificates
representing  the  Securities  to be sold  pursuant  to any  Shelf  Registration
Statement  free  of any  restrictive  legends  and  in  such  denominations  and
registered in such names as the Holders of  Securities  may request a reasonable
period  of time  prior  to  sales  of the  Securities  pursuant  to  such  Shelf
Registration Statement.

                 (viii)  Upon  the  occurrence  of  any  event  contemplated  by
paragraphs (B) through (E) of Section 5(c)(ii) above during the period for which
the  Corporation  is  required  to  maintain  an  effective  Shelf  Registration
Statement,  the  Corporation  shall promptly  prepare and file a  post-effective
amendment to the Shelf  Registration  Statement  or a supplement  to the related
prospectus and any other required  document so that, as thereafter  delivered to
Holders of Securities,  the prospectus will not contain an untrue statement of a
material fact or omit to state any material  fact required to be stated  therein
or necessary to make the statements therein, in light of the circumstances under
which they were made, not  misleading.  If the  Corporation  notifies  Investor,
Purchasers  and the Holders of  Securities  then  Investor,  Purchasers  and the
Holders of Securities  shall suspend use of such  prospectus,  and the period of
effectiveness of the Shelf  Registration  Statement provided for in Section 5(b)
above shall be extended by the number of days from and including the date of the
giving of such notice to and including the date when  Investor,  Purchasers  and
the Holders of  Securities  shall have  received  such  amended or  supplemented
prospectus pursuant to this Section 5(c)(viii).

                 (ix) The Corporation will comply with all rules and regulations
of the  Commission to the extent and so long as they are applicable to the Shelf
Registration  and will make  generally  available  to its  security  holders (or
otherwise  provide in accordance  with Section 11(a) of the  Securities  Act) an
earnings  statement  (which need not be audited)  satisfying  the  provisions of
Section  11(a) of the  Securities  Act, no later than 45 days after the end of a
12-month period (or 90 days, if such period is a fiscal year) beginning with the
first month of the  Corporation's  first  fiscal  quarter  commencing  after the
effective date of the Registration  Statement,  which statement shall cover such
12-month period.

                 (x) Each Holder of  Securities to be sold pursuant to the Shelf
Registration  Statement  shall  furnish  to  the  Corporation  such  information
regarding the Holder and the  distribution  of the Securities as the Corporation
may from time to time reasonably  require and request for inclusion in the Shelf
Registration  Statement (and shall promptly  correct any information  previously
furnished  if the  inclusion  of such  information  in such  Shelf  Registration
Statement would be materially misleading), and the Securities of any Holder that
unreasonably  fails to  furnish  such  information  that  unreasonably  fails to
furnish such information within a reasonable time after receiving such request.


                                     - 16 -
<PAGE>


                 (xi) The Corporation shall enter into such customary agreements
(including if requested an  underwriting  agreement in customary  form) and take
all such other  action,  if any, as any Holder of  Securities  shall  reasonably
request in order to facilitate the disposition of the Securities pursuant to any
Shelf  Registration.  If an  underwriting  agreement is entered into pursuant to
this  paragraph,  the  Corporation  shall  cause any such  agreement  to contain
indemnification  provisions  and procedures  substantially  similar to those set
forth in Section 5(j) hereof (or such other procedures acceptable to the Holders
of a majority of the aggregate  principal  amount of the  Securities  registered
under the applicable Shelf Registration Statement and the managing underwriters,
if any) with respect to all parties to be  indemnified  pursuant to Section 5(j)
hereof.

                 (xii) In the case of any Shelf  Registration,  the  Corporation
shall (A) make reasonably available for inspection by the Holders of Securities,
any  underwriter   participating  in  any  disposition  pursuant  to  the  Shelf
Registration  Statement and any attorney,  accountant or other agent retained by
the Holders of Securities  or any such  underwriter  all relevant  financial and
other records,  pertinent  corporate documents and properties of the Corporation
and (B) cause the Corporation's officers, directors, employees,  accountants and
auditors to supply all relevant information  reasonably requested by the Holders
of  Securities  or any  such  underwriter,  attorney,  accountant  or  agent  in
connection  with the  Shelf  Registration  Statement,  in each  case as shall be
reasonably  necessary,  in the  judgment of the Holder or any such  underwriter,
attorney,  accountant  or agent  referred  to in this  paragraph,  to  conduct a
reasonable investigation within the meaning of Section 11 of the Securities Act;
provided, however, that the foregoing inspection and information gathering shall
be coordinated  on behalf of the Investor,  Purchasers and Holders of Securities
by one counsel  designated  by and on behalf of such other parties and provided,
further,  that  as to any  information  that is  designated  in  writing  by the
Corporation,  in good  faith,  as  confidential  at the time of  delivery,  such
information  shall be kept  confidential  by the Holders of Securities or by any
such underwriter, attorney, accountant or other agent.

                 (xiii)  In  the  case  of  any  Shelf  Registration,   (A)  the
Corporation,  if reasonably requested by Holders of a majority of the Securities
covered by such Shelf  Registration,  which  request  shall not be more frequent
than once per fiscal quarter,  shall cause its counsel to deliver an opinion and
updates  thereof  relating to the Securities in customary form addressed to such
Holders  of  Securities  and  dated,  in the case of the  initial  opinion,  the
effective date of such Shelf  Registration  Statement,  provided such opinion is
requested  prior to the  effective  date (it being agreed that the matters to be
covered by such opinion shall include such matters as are  customarily  included
in opinions requested in underwritten  offerings);  and (B) the Corporation,  if
requested  by any  majority  of  Holders  of  Securities  covered  by such Shelf
Registration,  shall cause its  officers  to execute  and deliver all  customary
documents and certificates and updates thereof reasonably requested.

                 (xiv) In the event that any broker-dealer  registered under the
Exchange Act shall  underwrite  any  Securities or participate as a member of an
underwriting syndicate or


                                     - 17 -
<PAGE>


selling group or "assist in the  distribution"  (within the meaning of the Rules
of Fair  Practice  and the By-Laws of the  National  Association  of  Securities
Dealers, Inc. ("NASD")) thereof, whether as a Holder of such Securities or as an
underwriter,  a  placement  or sales  agent or a broker  or  dealer  in  respect
thereof, or otherwise, the Corporation shall use its best efforts to assist such
broker-dealer  in  complying  with the  requirements  of such Rules and By-Laws,
including, without limitation, by (A) if such Rules or By-Laws shall so require,
engaging a  "qualified  independent  underwriter"  (as  defined in Section  2720
thereof)  to  participate  in  the  preparation  of the  Registration  Statement
relating to such  Securities,  to exercise  usual  standards of due diligence in
respect  thereto and, if any portion of the offering  contemplated by such Shelf
Registration  Statement  is an  underwritten  offering  or  is  made  through  a
placement  or sales  agent,  to  recommend  the  yield of such  Securities,  (B)
indemnifying  any such  qualified  independent  underwriter to the extent of the
indemnification  of  underwriters  provided  in  Section  5(j)  hereof  and  (C)
providing such information to such broker-dealer as may be required in order for
such broker-dealer to comply with the requirements of the Rules of Fair Practice
of the NASD.

                 (xv) The  Corporation  shall use its best  efforts  to take all
other steps necessary to effect the registration of the Securities  covered by a
Shelf Registration Statement contemplated hereby.

            (d) Demand  Registration.  In the event of the  occurrence of any of
the  following  (1)  the  Corporation  fails  to  file  the  Shelf  Registration
Statement,  (2) the Corporation fails to cause the Shelf Registration  Statement
to be  continuously  effective,  or (3) the  expiration  of the  holding  period
referred to in Section 5(b)(ii), provided, however, that the Holders of at least
fifty percent (50%) of the  Registrable  Securities  then  outstanding  shall be
required in order to request  registration of the Registrable  Securities  under
Section 5(d)(3):

                 (i) If the  Corporation  receives  a written  request  from the
Holders of at least  fifty  percent  (50%) of the  Registrable  Securities  then
outstanding that the Corporation  file a registration  statement on Form S-1 (or
similar  successor  forms) under the Securities Act covering the registration of
the Registrable Securities, then the Corporation shall, within ten (10) business
days after the  receipt  thereof,  give  written  notice of such  request to all
Holders,  and  effect,  as soon  as  practicable,  the  registration  under  the
Securities Act of all  Registrable  Securities  which the Holders  request to be
registered and included in such registration, subject only to the limitations of
this Section 5(d).

                 (ii) If the Holders  initiating the registration  request under
this Section 5(d)  ("Initiating  Holders")  intend to distribute the Registrable
Securities  covered by their request by means of an underwriting,  they shall so
advise the  Corporation as a part of their request made pursuant to this Section
5(d) and the  Corporation  shall include such  information in the written notice
referred to in Section 5(d)(i) hereof. In such event, the right of any Holder to
include such  Holder's  Registrable  Securities  in such  registration  shall be
conditioned  upon  such  Holder's  participation  in such  underwriting  and the
inclusion of such Holder's  Registrable  Securities in the underwriting  (unless
otherwise  mutually  agreed by a majority in interest of the Initiating  Holders


                                     - 18 -
<PAGE>


and such  Holder)  to the extent  provided  herein.  All  Holders  proposing  to
distribute  their  securities  through  such  underwriting  shall  enter into an
underwriting  agreement  in  customary  form with the  managing  underwriter  or
underwriters selected for such underwriting.

                 (iii) The  Corporation is obligated to effect only two (2) such
registrations  pursuant to Section 5(d)(3) set forth above;  provided,  however,
that no such limitation shall apply with respect to the  circumstances set forth
in Section 5(d)(1) or 5(d)(2) set forth above.

                 (iv) All  expenses  incurred  in  connection  with  the  demand
registrations   effected  pursuant  to  this  Section  5(d),  including  without
limitation  all  federal and "blue sky"  registration  and  qualification  fees,
printers'  and  accounting  fees,  fees and  disbursements  of  counsel  for the
Corporation,  and of one counsel for the  participating  Holders  together  (the
"Registration Expenses") shall be borne by the Corporation.

                 (v) Notwithstanding  the requirement in Section 5(d)(i),  under
the  circumstances set forth in Section 5(d)(3) above, the Corporation may elect
to  effect  the   registration  of  the  Registrable   Securities  by  filing  a
registration  statement  on  Form  S-3  (or  similar  successor  forms)  if such
registration is not an underwritten offering of the Registrable Securities.

            (e) Piggyback Registrations.

                 (i) The  Corporation  shall  notify all Holders of  Registrable
Securities in writing at least forty-five (45) calendar days prior to filing any
registration  statement  under the  Securities  Act for  purposes of effecting a
public offering of securities of the Corporation (including, but not limited to,
registration  statements  relating to secondary  offerings of  securities of the
Corporation,  but  excluding  registration  statements  on an  Excluded  Form or
relating to any employee benefit plan or a corporate  reorganization)  and shall
afford each such Holder an opportunity to include in such registration statement
all or any part of the  Registrable  Securities  then held by such Holder.  Each
Holder desiring to include in any such registration statement all or any part of
the  Registrable  Securities  held by such  Holder  shall,  within  twenty  (20)
calendar days after receipt of the above-described  notice from the Corporation,
so notify the  Corporation  in  writing,  and in such  notice  shall  inform the
Corporation  of the  number of  Registrable  Securities  such  Holder  wishes to
include in such registration  statement.  If a Holder decides not to include all
of its Registrable  Securities in any registration statement thereafter filed by
the Corporation,  such Holder shall  nevertheless  continue to have the right to
include any Registrable  Securities in any subsequent  registration statement or
registration  statements  as may be filed by the  Corporation  with  respect  to
offerings of its securities, all upon the terms and conditions set forth herein.

                 (ii) If the registration  statement under which the Corporation
gives notice under this Section 5(e) (the  "Piggyback  Registration")  is for an
underwritten   offering,   the  Corporation  shall  so  advise  the  Holders  of
Registrable  Securities.   In  such  event,  the  right  of  any  such  Holder's
Registrable Securities to be included in a registration pursuant to this Section
5(e)


                                     - 19 -
<PAGE>


shall be conditioned upon such Holder's  participation in such  underwriting and
the inclusion of such Holder's Registrable Securities in the underwriting to the
extent provided herein.  All Holders  proposing to distribute their  Registrable
Securities through such underwriting shall enter into an underwriting  agreement
in such customary form with the managing  underwriter or  underwriters  selected
for  such  underwriting.  If any  Holder  disapproves  of the  terms of any such
underwriting,  such Holder may elect to withdraw  therefrom by written notice to
the Corporation and the  underwriter,  delivered at least five (5) business days
prior to the  effective  date of the  registration  statement.  Any  Registrable
Securities  excluded or withdrawn from such  underwriting  shall be excluded and
withdrawn from the registration.

                 (iii) If any of the Registrable  Securities registered pursuant
to any  Piggyback  Registration  are to be sold in one or more  firm  commitment
underwritten  offerings,  and the  managing  underwriters  advise in writing the
Corporation and the holders of such Registrable  Securities that in its or their
opinion or, in the case of a Piggyback Registration not being underwritten,  the
Corporation  shall  reasonably  determine (and notify the holders of Registrable
Securities of such determination),  after consultation with an investment banker
of  nationally  recognized  standing,  that the number of shares of Common Stock
(including Registrable  Securities) proposed to be sold in such offering exceeds
the maximum  number of shares of Common Stock that can be sold in such offering,
the Corporation  shall include in such  registration only such maximum number of
shares of Common Stock (including Registrable  Securities) which, in the opinion
of such  underwriter or underwriters,  or the  Corporation,  as the case may be,
selected in the  following  order of priority:  (i) first,  all of the shares of
Common Stock that the Corporation  proposes to sell for its own account, if any,
and (ii) second, the securities requested to be included in such registration by
Holders  and the Prior  Holders (as defined  below)  that have  requested  their
securities to be included therein, and which the managing  underwriters shall in
their reasonable  discretion deem advisable,  allocated pro rata, based upon the
number of shares of Common Stock that each such person  shall have  requested to
be included therein,  among (X) the Holders and (Y) persons having  registration
rights pursuant that certain Registration Rights Agreement,  dated September 29,
1995,  between  the  Corporation  and the  persons  named  therein  (the  "Prior
Holders").

                 (iv) All  Registration  Expenses  incurred in connection with a
registration pursuant to this Section 5(e) shall be borne by the Corporation.

            (f)  Additional  Registration  Rights.  If  the  Corporation  grants
registration rights to holders of any security of the Corporation which are more
favorable to such holders than the registration  rights granted hereunder,  then
such more  favorable  registration  rights shall also be deemed to be granted to
the  Holders  of the  Registrable  Securities  hereunder,  and  the  Corporation
covenants and agrees to take any and all steps  necessary to modify the terms of
this Agreement to so provide.


                                     - 20 -
<PAGE>


            (g) Obligations of the Corporation.  Whenever required to effect the
registration of any Registrable Securities under this Agreement, the Corporation
shall, as expeditiously as reasonably possible:

                 (i)  Prepare  and  file  with  the  Commission  a  registration
statement with respect to such  Registrable  Securities and use its best efforts
to cause such  registration  statement to become and remain effective within one
hundred  fifty  (150)  days  of  notice  from  the  Holders  of the  Registrable
Securities;

                 (ii) Prepare and file with the Commission  such  amendments and
supplements to such registration statement and the prospectus used in connection
with  such  registration  statement  as may be  necessary  to  comply  with  the
provisions  of  the  Securities  Act  with  respect  to the  disposition  of all
securities covered by such registration  statement and to keep such registration
statement effective, in the case of a firm commitment  underwriting,  until each
underwriter  has completed the  distribution  of all securities  purchased by it
and,  in the case of any other  offering,  until the  earlier of the sale of all
Registrable Securities covered thereby or one hundred eighty (180) calendar days
after the effective date thereof;  provided,  however,  that such 180-day period
shall be extended  for a period of time equal to the period the Holder  refrains
from selling any  Registrable  Securities  included in such  registration at the
request of an underwriter of the Common Stock or if the Corporation has provided
the notice described in subparagraph (vii) below;

                 (iii)  Furnish  to the  Holders  such  number  of  copies  of a
prospectus,   including  a  preliminary  prospectus,   in  conformity  with  the
requirements  of the  Securities  Act,  and  such  other  documents  as they may
reasonably  request in order to facilitate the  disposition  of the  Registrable
Securities owned by them that are included in such registration;

                 (iv)  Use  its  best   efforts  to  register  and  qualify  the
securities covered by such registration statement under such other securities or
blue sky laws of such  jurisdictions  as shall be  reasonably  requested  by the
Holders,  provided,  that the  Corporation  shall not be required in  connection
therewith  or as a  condition  thereto to qualify  to do  business  or to file a
general consent to service of process in any such states or jurisdictions;

                 (v) Use its best efforts to list the securities covered by such
registration statement with any securities exchange, if any, on which the Common
Stock of the Corporation is then listed;

                 (vi) In the event of any underwritten  public  offering,  enter
into and perform its obligations under an underwriting  agreement,  in usual and
customary form, with the managing  underwriter(s) of such offering.  Each Holder
participating  in such  underwriting  shall  also  enter  into and  perform  its
obligations under such an agreement;

                 (vii)  Notify each Holder of  Registrable  Securities  and each
underwriter  under such  registration  statement  at any time when a  prospectus
relating  thereto is required to be


                                     - 21 -
<PAGE>


delivered  under the Securities Act of the happening of any event as a result of
which the prospectus included in such registration statement, as then in effect,
includes  an untrue  statement  of a material  fact or omits to state a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading in the light of the  circumstances  then  existing,  and promptly
thereafter,  prepare and furnish to all Holders a reasonable number of copies of
an amended or supplemental prospectus as may be necessary so that, as thereafter
delivered to the  purchasers of such  Registrable  Securities,  such  prospectus
shall not  include an untrue  statement  of a  material  fact or omit to state a
material fact required to be stated  therein or necessary to make the statements
therein not misleading in the light of the circumstances then existing;

                 (viii)  Furnish,  at  the  request  of  any  Holder  requesting
registration  of  Registrable  Securities,  on the date  that  such  Registrable
Securities are delivered to the  underwriters  for sale, if such  securities are
being  sold  through  underwriters,  or, if such  securities  are not being sold
through underwriters,  on the date that the registration  statement with respect
to such securities becomes effective,  (A) an opinion, dated as of such date, of
the counsel representing the Corporation, for the purposes of such registration,
in form and substance as is customarily given to underwriters in an underwritten
public  offering and  reasonably  satisfactory  to a majority in interest of the
Holders requesting registration,  addressed to the underwriters,  if any, and to
the  Holders  requesting  registration  of  Registrable  Securities  and  (B)  a
"comfort"  letter dated as of such date, from the independent  certified  public
accountants of the Corporation, in form and substance as is customarily given by
independent  certified  public  accountants to  underwriters  in an underwritten
public  offering and  reasonably  satisfactory  to a majority in interest of the
Holders requesting registration,  addressed to the underwriters,  if any, and to
the Holders requesting registration of the Registrable Securities; and

                 (ix)  Make   available   for   inspection  by  each  seller  of
Registrable  Securities,  any  underwriter  participating  in  any  distribution
pursuant to such registration statement,  and any attorney,  accountant or other
agent retained by such seller or  underwriter,  all financial and other records,
pertinent corporate  documents and properties of the Corporation,  and cause the
Corporation's  officers,  directors  and  employees  to supply  all  information
reasonably requested by any such seller,  underwriter,  attorney,  accountant or
agent in connection with such registration statement.

            (h) Furnish  Information.  It shall be a condition  precedent to the
obligations  of the  Corporation  to take any action  pursuant to Sections 5(b),
5(d) and 5(e) that the selling  Holders  shall furnish to the  Corporation  such
information regarding themselves,  the Registrable  Securities held by them, and
the intended  method of disposition  of such  securities as shall be required to
effect the registration of their Registrable Securities.

            (i)  Indemnification.  In the event any  Registrable  Securities are
included in a registration statement under Sections 5(b), 5(d) or 5(e):


                                     - 22 -
<PAGE>


                 (i) To the  extent  permitted  by law,  the  Corporation  shall
indemnify and hold harmless each Holder, the partners, officers and directors of
each Holder,  any underwriter (as defined in the Securities Act) for such Holder
and each  person,  if any, who controls  such Holder or  underwriter  within the
meaning of the Securities Act or the Exchange Act,  against any losses,  claims,
damages,  or  liabilities  (joint or several)  to which they may become  subject
under the  Securities  Act,  the  Exchange  Act or other  federal  or state law,
insofar as such losses,  claims,  damages or liabilities  (or actions in respect
thereof)  arise  out of or are  based  upon  any  of the  following  statements,
omissions or violations (collectively, a "Violation"):

                    (A) any untrue  statement or alleged  untrue  statement of a
material  fact  contained  in  such   registration   statement,   including  any
preliminary  prospectus or final prospectus  contained therein or any amendments
or supplements thereto,

                    (B) the  omission  or alleged  omission  to state  therein a
material fact required to be stated therein, or necessary to make the statements
therein not misleading, or

                    (C) any violation or alleged violation by the Corporation of
the Securities Act, the Exchange Act, any federal or state securities law or any
rule or regulation promulgated under the Securities Act, the Exchange Act or any
federal or state  securities law in connection with the offering covered by such
registration statement,

            and the Corporation  shall reimburse each such Holder, or a partner,
officer or director,  underwriter or  controlling  person of such Holder for any
legal or other expenses reasonably incurred by them, as incurred,  in connection
with  investigating  or defending  any such loss,  claim,  damage,  liability or
action;  provided,  however,  that the  indemnity  agreement  contained  in this
Section  5(j) shall not apply to amounts  paid in  settlement  of any such loss,
claim,  damage,  liability or action if such settlement is effected  without the
consent of the Corporation (which consent shall not be unreasonably  withheld or
delayed),  nor shall the  Corporation  be liable in any case for any such  loss,
claim,  damage,  liability  or action to the extent  that it arises out of or is
based upon a Violation  which  occurs in reliance  upon and in  conformity  with
written  information  furnished  expressly  for  use  in  connection  with  such
registration by such Holder,  or a partner,  officer,  director,  underwriter or
controlling person of such Holder.

                 (ii) To the extent  permitted by law, each selling Holder shall
indemnify and hold harmless the Corporation,  each of its directors and officers
who have signed the registration  statement,  each person,  if any, who controls
the  Corporation  within the meaning of the Securities  Act, any underwriter and
any other Holder selling securities under such registration  statement or any of
such other Holder's  partners,  directors or officers or any person who controls
such  Holder  within the  meaning of the  Securities  Act or the  Exchange  Act,
against any losses,  claims,  damages or liabilities (joint or several) to which
the Corporation or any such director,  officer,  controlling person, underwriter
or other such Holder, or a partner,  director,  officer or controlling person of
such other Holder may become subject under the Securities  Act, the Exchange Act
or other  federal  or state  law,  insofar as such  losses,  claims,  damages or
liabilities


                                     - 23 -
<PAGE>



(or actions in respect thereto) arise out of or are based upon any Violation, in
each case to the extent (and only to the extent) that such  Violation  occurs in
reliance  upon and in  conformity  with  written  information  furnished by such
Holder  expressly for use in connection  with such  registration;  and each such
Holder shall  reimburse any legal or other expenses  reasonably  incurred by the
Corporation or any such director,  officer,  controlling person,  underwriter or
other Holder,  partner,  officer,  director or controlling  person of such other
Holder in  connection  with  investigating  or defending  any such loss,  claim,
damage,  liability or action;  provided,  however,  that the indemnity agreement
contained in this Section 5(j) shall not apply to amounts paid in  settlement of
any such loss, claim, damage, liability or action if such settlement is effected
without the  consent of the  Holder,  which  consent  shall not be  unreasonably
withheld; and provided,  further, that the total amounts payable in indemnity by
a Holder  under this  Section  5(j)(ii)  in respect of any  Violation  shall not
exceed the net proceeds  received by such Holder in the registered  offering out
of which such Violation arises.

                 (iii) Promptly after receipt by an indemnified party under this
Section  5(j)  of  notice  of the  commencement  of any  action  (including  any
governmental  action),  such  indemnified  party  shall,  if a claim in  respect
thereof is to be made against any  indemnifying  party under this Section  5(j),
deliver to the indemnifying  party a written notice of the commencement  thereof
and the  indemnifying  party shall have the right to participate in, and, to the
extent the indemnifying  party so desires,  jointly with any other  indemnifying
party similarly  noticed,  to assume the defense  thereof with counsel  mutually
satisfactory to the parties; provided,  however, that an indemnified party shall
have the right to retain its own counsel,  with the fees and expenses to be paid
by the indemnifying  party, if  representation  of such indemnified party by the
counsel retained by the indemnifying  party would be inappropriate due to actual
or potential  differing  interests  between such indemnified party and any other
party  represented  by such counsel in such  proceeding.  The failure to deliver
written  notice  to the  indemnifying  party  within  a  reasonable  time of the
commencement  of any such action,  if  prejudicial to its ability to defend such
action,   shall  relieve  such  indemnifying  party  of  any  liability  to  the
indemnified  party  under this  Section  5(j),  but the  omission  so to deliver
written notice to the  indemnifying  party shall not relieve it of any liability
that it may have to any  indemnified  party  otherwise  than under this  Section
5(j).

                 (iv) In order to provide for just and equitable contribution to
joint  liability  under the  Securities  Act in any case in which either (A) any
Holder exercising rights under this Agreement,  or any controlling person of any
such Holder, makes a claim for indemnification pursuant to this Section 5(j) but
it is  judicially  determined  (by the entry of a final  judgment or decree by a
court of  competent  jurisdiction  and the  expiration  of time to appeal or the
denial  of the last  right  of  appeal)  that  such  indemnification  may not be
enforced in such case  notwithstanding  the fact that this Section 5(j) provides
for  indemnification  in such case, or (B) contribution under the Securities Act
may be required on the part of any such selling  Holder or any such  controlling
person in circumstances for which indemnification is provided under this Section
5(j),  then,  and in each  such  case,  the  Corporation  or such  Holder  shall
contribute  to the  aggregate  losses,  claims,  damages  or  liabilities  as is
appropriate  to  reflect  not  only  the  relative   benefits  received  by  the
indemnified party and the indemnifying party, but also the relative fault of


                                     - 24 -
<PAGE>


the indemnified party and the indemnifying  party, as well as any other relevant
equitable  considerations.  The relative  fault of such  indemnifying  party and
indemnified  parties  shall be  determined  by reference to, among other things,
whether any action in question, including any untrue or alleged untrue statement
of a material fact or omission or alleged omission to state a material fact, has
been made by, or relates to information  supplied by, such indemnifying party or
indemnified  parties,  and the parties'  relative intent,  knowledge,  access to
information  and  opportunity  to  correct  or prevent  such  action;  provided,
however,  that,  in any such  case,  (1) no such  Holder  shall be  required  to
contribute  any  amount  in  excess  of the  public  offering  price of all such
Registrable  Securities  offered  and  sold  by  such  Holder  pursuant  to such
registration statement; and (2) no person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution   from  any  person   who  was  not   guilty  of  such   fraudulent
misrepresentation.

                 (v) The  obligations of the  Corporation and Holders under this
Section  5(j) shall  survive  the  completion  of any  offering  of  Registrable
Securities in a registration statement, and the termination of this Agreement.

            (j) "Market Stand-Off" Agreement. Holder hereby agrees that it shall
not, to the extent  requested by the  Corporation  and an  underwriter of Common
Stock  of  the  Corporation,  sell  or  otherwise  transfer  or  dispose  of any
Registrable  Securities  (other than Registrable  Securities being registered in
such  offering) for up to that period of time  following the effective date of a
registration  statement of the Corporation  filed under the Securities Act as is
requested by the managing  underwriter(s)  of such  offering,  not to exceed one
hundred twenty (120) calendar days; provided, however, that:

                 (i) such agreement  shall be applicable  only to the first such
registration  statement of the Corporation which covers securities to be sold on
its  behalf to the public in an  underwritten  offering  but not to  Registrable
Securities sold pursuant to such registration statement; and

                 (ii) all  officers,  directors and ten percent (10%) or greater
stockholders of the Corporation,  provided such  stockholders have acquired such
securities  directly  from the  Corporation,  then  holding  Common Stock of the
Corporation, shall enter into similar agreements.

            In order to enforce the  foregoing  covenant,  the  Corporation  may
impose stop transfer instructions with respect to the then-remaining Registrable
Securities  of each Holder (and the shares or  securities  of every other person
subject to the foregoing restriction) until the end of such period.

            (k) Rule 144 Reporting. With a view to making available the benefits
of certain rules and regulations of the Commission  which may at any time permit
the sale of the Registrable  Securities to the public without registration,  the
Corporation agrees to:


                                     - 25 -
<PAGE>


                 (i) Make and keep public information available,  as those terms
are understood and defined in Rule 144 under the Securities Act;

                 (ii) File with the  Commission  in a timely  manner all reports
and other documents required of the Corporation under the Securities Act and the
Exchange Act; and

                 (iii) So long as a  Holder  owns  any  Registrable  Securities,
furnish  to the  Holder  forthwith  upon  request  a  written  statement  by the
Corporation as to its compliance  with the reporting  requirements  of said Rule
144, and of the  Securities  Act and the Exchange Act, a copy of the most recent
annual or  quarterly  report of the  Corporation,  and such  other  reports  and
documents  of the  Corporation  as a Holder may  reasonably  request in availing
itself of any rule or regulation of the Commission allowing a Holder to sell any
such securities without registration.

            (l)  Removal  of  Legends,   Etc.   Notwithstanding   the  foregoing
provisions  of this Section 5, the  restrictions  imposed by this Section 5 upon
the transferability of any Registrable Securities shall cease and terminate when
any such Registrable  Securities are sold or otherwise disposed of in accordance
with the intended  method of  disposition  by the seller or sellers  thereof set
forth in the  registration  statement which does not require that the securities
transferred bear the legend set forth in Section 5(a). Whenever the restrictions
imposed by this Section 6 shall terminate as herein provided,  the Holder of any
Registrable  Securities as to which such  restrictions  have terminated shall be
entitled  to receive  from the  Corporation,  without  expense,  one or more new
certificates  not bearing the  restrictive  legend set forth in Section 5(a) and
not containing any other reference to the  restrictions  imposed by this Section
5.

            (m) Filing of Reports Under the Exchange Act. The Corporation  shall
give prompt notice to the Investor and Purchasers of:

                 (i) the filing of an Exchange Act Registration Statement; and

                 (ii)  the  effectiveness  of  such  Exchange  Act  Registration
Statement  and  the  number  of  shares  of  such  class  of  equity  securities
outstanding as reported in such Exchange Act Registration Statement, in order to
enable the parties to this  Agreement to comply with any reporting  requirements
under the Exchange Act or the Securities Act. The Corporation shall, at any time
after the  Corporation  shall  register  any  shares of Common  Stock  under the
Securities Act and upon the written  request of Investor or any Purchaser,  file
an  Exchange  Act  Registration  Statement  relating  to  any  class  of  Equity
Securities of the Corporation then held by Investor or Purchaser, whether or not
the class of equity  securities with respect to which such request is made shall
be held by at least the number of persons  which  would  require the filing of a
registration   statement  under  Section  12(g)(1)  of  the  Exchange  Act.  The
Corporation  shall comply with all the  reporting  requirements  of the Exchange
Act, and shall comply with all other public information  reporting  requirements
of the  Commission as a condition to the  availability  of an exemption from the
Securities  Act  (under  Rule 144  thereof,  as  amended  from time to time,  or
successor rule thereto or otherwise) for the sale of Common Stock by Investor or
the Purchasers.  The Corporation shall cooperate with Investor and Purchasers in
supplying  such  information  as may be


                                     - 26 -
<PAGE>


necessary  for  Investor  or  Purchasers  to complete  and file any  information
reporting forms presently or hereafter required by the Commission as a condition
to the  availability  of an exemption  from the  Securities  Act (under Rule 144
thereof or otherwise) for the sale of Common Stock by Investor or any Purchaser.

            (n) Underwritten Registration.  If any of the Registrable Securities
are to be sold in an underwritten  offering, the investment banker or investment
bankers  and manager or  managers  that will  administer  the  offering  will be
selected by the  Corporation  and, in the case of a registration  effected under
Sections  5(b),  5(d) or 5(f),  approved  in writing by the  Holders of at least
fifty (50%) percent of the Registrable  Securities requesting inclusion of their
Registrable Securities in such registration statement.


            SECTION 6. DURATION OF AGREEMENT.  Except for those provisions that,
by their terms, terminate sooner, all rights and obligations of Investor or each
Purchaser under this Agreement shall terminate as to Investor and each Purchaser
upon written  consent of the holders of at least  sixty-six  and 67/100  percent
(66.67%) of the shares of Series D Preferred Stock  (including  shares of Common
Stock into which converted).


            SECTION 7.  SEVERABILITY;  GOVERNING  LAW. If any provisions of this
Agreement  shall be determined to be illegal and  unenforceable  by any court of
law, the remaining  provisions  shall be severable and enforceable in accordance
with  their  terms.   The  parties  hereto  agree  that  Investor  would  suffer
irreparable  damage would occur in the event that any of the  provisions of this
Agreement  were not performed in accordance  with their  specific  terms or were
otherwise  breached by the Corporation.  It is accordingly  agreed that Investor
shall be entitled to an injunction or  injunctions  to prevent  breaches of this
Agreement and to enforce  specifically  the terms and  provisions  hereof in any
state  court  located in the State of New York,  or the United  States  District
Court for the Southern District of New York or any federal court in the State of
New York (as to which the Corporation  agrees to submit to jurisdiction  for the
purposes  of such or any other  action),  this  being in  addition  to any other
remedy to which  Investor is  entitled at law or in equity,  and, if Investor is
successful  on the  merits  in any such  action,  that the  costs  and  expenses
(including   reasonable   attorneys'  fees)  incurred  by  Investor  in  seeking
enforcement  of this Agreement or the  Certificate  of Designation  shall be the
sole and exclusive  responsibility  of the Corporation.  This Agreement shall be
governed by, and construed in accordance with, the laws of the State of Delaware
excluding its principles of conflicts of law.


            SECTION 8. BENEFITS OF AGREEMENT.  This  Agreement  shall be binding
upon and inure to the benefit of the parties and their respective successors and
assigns,  legal  representatives  and  heirs.  Subject  to  the  terms  of  this
Agreement,  including the five percent (5%) limitation set forth below, Investor
or any  Purchaser  may  transfer  any or all  of  its  rights  hereunder  to any
purchaser or transferee of all or a portion of the currently  outstanding shares
of Series D Preferred Stock,  including any right or interest  therein,  without
the  prior  written  consent  of  the  Corporation  or  any  stockholder  of the
Corporation. In the event that a transfer involves at least five percent (5%) of
the  currently  outstanding  shares of Series D Preferred  Stock,  including any


                                     - 27 -
<PAGE>


right or interest therein,  such transferee shall be deemed to be "Investor," or
"Purchaser" and a "Holder", as appropriate,  for purposes of this Agreement, and
may again transfer such rights in accordance  with, and subject to, the terms of
this Agreement.


            SECTION 9. NOTICES. All notices, requests, claims, demands and other
communications  hereunder  shall be in writing  and shall be deemed to have been
duly given when delivered in person, by cable, telegram,  facsimile transmission
with  confirmation  of receipt,  or telex,  or by registered  or certified  mail
(postage  prepaid,  return  receipt  requested)  to the  respective  parties  as
follows:

                        if to Investor:
                        ---------------

                        OCM Principal Opportunities Fund, L.P.
                        c/o Oaktree Capital Management, LLC
                        333 South Grand Avenue, 28th Floor
                        Los Angeles, CA 90071
                        Attention:  Stephen Kaplan, Principal
                                    Phone:  213-830-6350
                                    Michael P. Harmon, Vice President
                                    Phone:  213-830-6352
                                    Fax:    213-830-6395

                        with a required copy to:
                        ------------------------

                        Dechert Price & Rhoads
                        4000 Bell Atlantic Tower
                        1717 Arch Street
                        Philadelphia, PA  19103
                        Attention:  Donna E. Ostroff, Esq.
                                    Phone:  215-994-4000
                                    Fax:    215-994-2222

                        If to Purchasers:

                        See Exhibit A hereto.

                        if to the Company:
                        ------------------

                        CollaGenex Pharmaceuticals, Inc.
                        301 South State St.
                        Newtown, PA 18940
                        Attention:  Nancy Broadbent,
                                    Senior Vice President and
                                     Chief Financial Officer
                                    Phone:  215-579-7388
                                    Fax:    215-579-8577


                                     - 28 -
<PAGE>


                        with a required copy to:
                        ------------------------

                        Buchanan Ingersoll Professional Corporation
                        Princeton Forrestal Center
                        500 College Road East
                        Princeton, NJ 08540
                        Attention:  David J. Sorin, Esq.
                                    Phone:  609-987-6800
                                    Fax:    609-520-0360

or to such  other  address  as the  person  to whom  notice  is  given  may have
previously  furnished  to the others in  writing  in the manner set forth  above
(provided  that  notice of any change of address  shall be  effective  only upon
receipt thereof).


            SECTION 10. CHANGES.  The terms and provisions of this Agreement may
not be modified or amended, or any of the provisions hereof waived,  temporarily
or  permanently,  except  pursuant to the  written  consent of the holders of at
least sixty-six and 67/100 percent  (66.67%) of the shares of Series D Preferred
Stock (including shares of Common Stock into which converted,  or in the case of
the Convertible  Note, the Holder of the  Convertible  Note or the holders of at
least  sixty-six and 67/100 percent  (66.67%) of the shares of Common Stock upon
conversion of the Convertible  Note).  Any rights  applicable to Investor may be
waived by Investor  without the consent of the  Corporation,  Purchasers  or the
other stockholders of the Corporation.


            SECTION  11.   CAPTIONS.   The  captions  herein  are  inserted  for
convenience  only and shall not define,  limit,  extend or describe the scope of
this Agreement or affect the construction hereof.


            SECTION 12.  NOUNS AND  PRONOUNS.  Whenever the context may require,
any pronouns used herein shall include the corresponding masculine,  feminine or
neuter  forms and the  singular  form of names and  pronouns  shall  include the
plural and vice-versa.

            SECTION 13.  MERGER  PROVISION.  This  Agreement (as the same may be
amended from time to time), the Stock Purchase  Agreement,  the Convertible Loan
Agreement  and  the  Convertible   Note  constitute  the  entire  agreement  and
understanding  among the parties  pertaining  to the subject  matter  hereof and
supersede all prior and contemporaneous agreements therewith.


            SECTION 14.  COUNTERPARTS.  This Agreement may be executed in one or
more counterparts,  each of which shall be deemed to be an original,  but all of
which taken together shall constitute one and the same instrument.


                                     - 29 -
<PAGE>


            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed on their behalf.


                                    CORPORATION:
                                    ------------

                                    COLLAGENEX PHARMACEUTICALS, INC.

                                    By: /s/ Brian M. Gallagher
                                       -----------------------------------
                                       Name:  Brian M. Gallagher
                                       Title: President and Chief Executive
                                               Officer

                                    By: /s/ Nancy C. Broadbent
                                       -----------------------------------
                                       Name:  Nancy C. Broadbent
                                       Title: Vice President and Chief Financial
                                               Officer



                                    INVESTOR:
                                    ---------

                                    OAKTREE PRINCIPAL OPPORTUNITIES FUND, L.P.

                                    By: Oaktree Capital Management, LLC, its
                                        general partner

                                    By: /s/ Stephen Kaplan
                                       -----------------------------------
                                       Name:  Stephen Kaplan
                                       Title: Principal

                                    By: /s/ Michael Harmon
                                       -----------------------------------
                                       Name:  Michael Harmon
                                       Title: Vice President



                                    PURCHASERS:
                                    -----------

                                    /s/ Richard A. Horstmann
                                    --------------------------------------
                                    Richard A. Horstmann


                   [SIGNATURES CONTINUE ON THE FOLLOWING PAGE]


                                     - 30 -
<PAGE>


                                    MARQUETTE VENTURE PARTNERS II, L.P.

                                    By: /s/ James E. Daverman
                                       -----------------------------------
                                       Name:  James E. Daverman
                                       Title: Authorized Signatory


                                    MVP II AFFILIATES FUND, L.P.

                                    By: /s/ James E. Daverman
                                       -----------------------------------
                                       Name:  James E. Daverman
                                       Title: Authorized Signatory

                                    /s/ Robert J. Easton
                                    --------------------------------------
                                    Robert J. Easton

                                    PEBBLEBROOK PARTNERS LTD


                                    By: /s/ Stuart Schube
                                       -----------------------------------
                                       Name:  Stuart Schube
                                       Title: General Partner


                                     - 31 -
<PAGE>




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