COLLAGENEX PHARMACEUTICALS INC
DEF 14A, 2000-04-14
PHARMACEUTICAL PREPARATIONS
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                                  SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934


Filed by the Registrant      |X|
Filed by a Party other than the Registrant   |_|

Check the appropriate box:
|_|  Preliminary Proxy Statement          |_|  Confidential, for Use of
                                               the Commission Only (as
                                               permitted by Rule 14a-6(e)(2))
|X|  Definitive Proxy Statement
|_|  Definitive Additional Materials
|_|  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

                        CollaGenex Pharmaceuticals, Inc.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
      (Name of Person(s) Filing Proxy Statement, if other than Registrant)


Payment of Filing Fee (Check the appropriate box):
  |X|  No fee required.
  |_|  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

  (1)  Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------

  (2)  Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------

  (3)  Per unit price or other underlying value of transaction computed pursuant
to  Exchange  Act Rule 0-11 (set  forth the  amount on which the  filing  fee is
calculated and state how it was determined):

- --------------------------------------------------------------------------------

  (4)  Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------

  (5)  Total fee paid:

- --------------------------------------------------------------------------------

  |_|  Fee paid previously with preliminary materials.

- --------------------------------------------------------------------------------

  |_|  Check box if any part of the fee is offset as provided  by  Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

  (1)  Amount Previously Paid:

- --------------------------------------------------------------------------------

  (2)  Form, Schedule or Registration Statement no.:

- --------------------------------------------------------------------------------

  (3)  Filing Party:

- --------------------------------------------------------------------------------

  (4)  Date Filed:

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<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940


                                            April 14, 2000

To Our Stockholders:

      You  are  cordially   invited  to  attend  the  2000  Annual   Meeting  of
Stockholders of CollaGenex  Pharmaceuticals,  Inc. at 8:30 A.M.,  local time, on
Monday,  May 8, 2000, at the Marriott Hotel,  1201 Market Street,  Philadelphia,
Pennsylvania.

      The Notice of Meeting and Proxy  Statement on the following pages describe
the matters to be presented at the meeting.

      It is important  that your shares be represented at this meeting to assure
the presence of a quorum. Whether or not you plan to attend the meeting, we hope
that you will have your stock represented by signing,  dating and returning your
proxy in the enclosed envelope, as soon as possible. Your stock will be voted in
accordance with the instructions you have given in your proxy.

      Thank you for your continued support.

                                            Sincerely,


                                            /s/ Brian M. Gallagher, Ph.D.
                                                President and
                                                Chief Executive Officer


<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                             To Be Held May 8, 2000

      The  Annual  Meeting  of   Stockholders   (the  "Meeting")  of  COLLAGENEX
PHARMACEUTICALS,  INC., a Delaware corporation (the "Company"),  will be held at
the Mariott Hotel, 1201 Market Street,  Philadelphia,  Pennsylvania,  on Monday,
May 8, 2000, at 8:30 A.M., local time, for the following purposes:

(1)   To elect  eight  directors  to serve  until  the next  Annual  Meeting  of
      Stockholders  and until their  respective  successors shall have been duly
      elected and qualified;

(2)   To ratify the appointment of KPMG LLP as independent auditors for the year
      ending December 31, 2000; and

(3)   To transact such other business as may properly come before the Meeting or
      any adjournment or adjournments thereof.

      Holders of Common  Stock and  Series D  Cumulative  Convertible  Preferred
Stock of record at the close of business on April 5, 2000 are entitled to notice
of and to vote at the Meeting,  or any  adjournment or adjournments  thereof.  A
complete  list of such  stockholders  will  be  open to the  examination  of any
stockholder at the Company's principal executive offices at 41 University Drive,
Newtown,  Pennsylvania  18940 and at the  Mariott  Hotel,  1201  Market  Street,
Philadelphia,  Pennsylvania,  for a period of 10 days prior to the Meeting.  The
Meeting  may be  adjourned  from  time  to time  without  notice  other  than by
announcement at the Meeting.

      IT IS IMPORTANT THAT YOUR SHARES BE  REPRESENTED  REGARDLESS OF THE NUMBER
OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN PERSON,
PLEASE  COMPLETE,  DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT PROMPTLY IN
THE ENCLOSED RETURN ENVELOPE.  THE PROMPT RETURN OF PROXIES WILL ENSURE A QUORUM
AND SAVE THE COMPANY THE EXPENSE OF FURTHER SOLICITATION. EACH PROXY GRANTED MAY
BE REVOKED BY THE  STOCKHOLDER  APPOINTING  SUCH PROXY AT ANY TIME  BEFORE IT IS
VOTED.  IF YOU  RECEIVE  MORE  THAN ONE  PROXY  CARD  BECAUSE  YOUR  SHARES  ARE
REGISTERED  IN  DIFFERENT  NAMES OR  ADDRESSES,  EACH SUCH PROXY CARD  SHOULD BE
SIGNED AND RETURNED TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.

                                            By Order of the Board of Directors


                                            /s/ Nancy C. Broadbent
                                                Secretary

Newtown, Pennsylvania
April 14, 2000

        THE COMPANY'S 1999 ANNUAL REPORT ACCOMPANIES THE PROXY STATEMENT.


<PAGE>


                        COLLAGENEX PHARMACEUTICALS, INC.
                               41 University Drive
                                Newtown, PA 18940

          ------------------------------------------------------------
                                 PROXY STATEMENT
          ------------------------------------------------------------

      This Proxy Statement is furnished in connection  with the  solicitation by
the Board of Directors of CollaGenex  Pharmaceuticals,  Inc. (the  "Company") of
proxies to be voted at the Annual Meeting of  Stockholders  of the Company to be
held on Monday,  May 8, 2000 (the "Meeting") at the Marriott Hotel,  1201 Market
Street,  Philadelphia,  Pennsylvania  at  8:30  A.M.,  local  time,  and  at any
adjournment or adjournments thereof. Holders of record of Common Stock, $.01 par
value (the "Common Stock"), and Series D Cumulative Convertible Preferred Stock,
$.01 par value (the "Series D Preferred Stock"),  as of the close of business on
April 5, 2000,  will be entitled to notice of and to vote at the Meeting and any
adjournment  or  adjournments  thereof.  As of that date,  there were  8,678,154
shares of Common Stock issued and  outstanding  and entitled to vote and 200,000
shares of Series D Preferred  Stock issued and outstanding and entitled to vote.
Such shares of Series D Preferred Stock were, as of such date,  convertible into
1,818,182 shares of Common Stock.  Except for the proposal to elect the Series D
Director (as  hereinafter  defined),  as set forth  below,  each share of Common
Stock is  entitled  to one vote on any  matter  presented  at the  Meeting.  The
aggregate  number of Common  Stock  votes  entitled to be cast at the Meeting is
10,496,336,  including the 1,818,182  shares  underlying  the Series D Preferred
Stock to be voted on an as converted  to Common Stock basis.  The holders of all
classes of stock will vote as a single class for all proposals generally, except
that the holders of Series D Preferred  Stock will also vote as a separate class
for the proposal to elect the Series D Director.

      If proxies in the  accompanying  form are properly  executed and returned,
the shares of Common Stock and Series D Preferred Stock represented thereby will
be voted in the manner specified therein. If not otherwise specified, the shares
of Common Stock and Series D Preferred Stock  represented by the proxies will be
voted (i) FOR, as applicable,  the election of the eight nominees named below as
directors,  (ii)  FOR  the  ratification  of  the  appointment  of  KPMG  LLP as
independent  auditors for the year ending  December  31, 2000,  and (iii) in the
discretion  of the persons  named in the  enclosed  form of proxy,  on any other
proposals  which may  properly  come  before the Meeting or any  adjournment  or
adjournments thereof. Any Stockholder who has submitted a proxy may revoke it at
any time before it is voted, by written notice  addressed to and received by the
Secretary of the Company,  by submitting a duly  executed  proxy bearing a later
date or by electing to vote in person at the Meeting.  The mere  presence at the
Meeting  of the  person  appointing  a  proxy  does  not,  however,  revoke  the
appointment.

      The presence, in person or by proxy, of holders of shares of Common Stock,
including the shares of Common Stock  underlying the Series D Preferred Stock to
be voted on an as converted to Common Stock  basis,  in the  aggregate  having a
majority of the votes  entitled to be cast by the holders of Common Stock at the
Meeting,  shall  constitute a quorum with respect to all matters  except for the
election  of the Series D  Director.  The  presence,  in person or by proxy,  of
holders of shares of Series D  Preferred  Stock  having a majority  of the votes
entitled to be cast by the  holders of Series D  Preferred  Stock at the Meeting
shall constitute a quorum with respect to the election of the Series D Director.
The affirmative vote by the holders of a plurality of the shares of Common Stock
represented  at the  Meeting,  but not  including  the  shares of  Common  Stock
underlying the Series D Preferred Stock to be voted on an as converted to Common
Stock basis,  is required for the election of directors  other than the Series D
Director,  provided  a quorum of such  Stockholders  is  present in person or by
proxy. The affirmative vote by the holders of a majority of the shares of Series
D Preferred  Stock is required  for the  election of the Series D Director.  All
actions  proposed  herein other than the election of directors may be taken upon
the  affirmative  vote of  Stockholders  possessing a majority of the  requisite
voting power represented at the Meeting,  provided a quorum is present in person
or by proxy.

      Abstentions are included in the shares present at the Meeting for purposes
of  determining  whether a quorum is present,  and are counted as a vote against
for purposes of  determining  whether a proposal is approved.  Broker



<PAGE>


non-votes  (when shares are  represented at the Meeting by a proxy  specifically
conferring only limited authority to vote on certain matters and no authority to
vote on other matters) are included in the determination of the number of shares
represented  at the Meeting  for  purposes  of  determining  whether a quorum is
present but are not counted for purposes of  determining  whether a proposal has
been approved and thus have no effect on the outcome.

      This Proxy  Statement,  together  with the related  proxy cards,  is being
mailed to the Stockholders of the Company on or about April 14, 2000. The Annual
Report to  Stockholders  of the Company for the year ended  December  31,  1999,
including financial  statements (the "Annual Report"),  is being mailed together
with this Proxy Statement to all  Stockholders of record as of April 5, 2000. In
addition, the Company has provided brokers,  dealers, banks, voting trustees and
their nominees,  at the Company's expense,  with additional copies of the Annual
Report so that such record  holders  could supply such  materials to  beneficial
owners as of April 5, 2000.


                                       2

<PAGE>


                              ELECTION OF DIRECTORS

      At the Meeting,  eight  directors  are to be elected  (which  number shall
constitute  the entire  Board of  Directors of the Company) to hold office until
the next Annual Meeting of Stockholders  and until their  successors  shall have
been elected and qualified. The holders of Common Stock, voting as a class, will
elect seven  directors.  The holders of Series D  Preferred  Stock,  voting as a
class, will elect one director (the "Series D Director").

      It is the  intention of the persons named in the enclosed form of proxy to
vote the stock represented thereby, unless otherwise specified in the proxy, for
the  election as  directors of the persons  whose names and  biographies  appear
below.  All such persons are at present  directors of the Company.  In the event
any of the nominees should become  unavailable or unable to serve as a director,
it is intended  that votes will be cast for a substitute  nominee  designated by
the Board of Directors. The Board of Directors has no reason to believe that the
nominees  named will be unable to serve if  elected.  Each of the  nominees  has
consented to being named in this Proxy Statement and to serve if elected.

      The current  members of the Board of Directors  who are also  nominees for
election to the Board of Directors are as follows:

Common Stock Directors:
- -----------------------
                                        Served as a       Positions with
Name                             Age   Director Since      the Company
- ----                             ---   --------------     ---------------

Brian M. Gallagher, Ph.D.......   52       1994           President, Chief
                                                          Executive Officer,
                                                          Chairman of the Board

Helmer P.K. Agersborg, Ph.D....   71       1992           Director

Peter R. Barnett, D.M.D........   48       1997           Director

Robert C. Black................   57       1999           Director

James E. Daverman..............   50       1995           Director

Robert J. Easton...............   55       1993           Director

Terence E. Winters, Ph.D.......   57       1992           Director


Series D Preferred Stock Director:
- ----------------------------------

Stephen A. Kaplan..............   41       1999           Director

      The  principal  occupations  and business  experience,  for at least the
past five years, of each nominee are as follows:

      Dr.  Gallagher  joined the  Company in April 1994 as  President  and Chief
Executive Officer and was elected to the Board of Directors in November 1994. On
March 10, 2000, Dr. Gallagher was appointed  Chairman of the Board of Directors.
From 1988 until joining the Company, Dr. Gallagher was employed by Bristol-Myers
Squibb Company and its predecessor,  Squibb  Corporation,  in various  executive
positions  including   strategic   planning,   worldwide  product  and  business
development and marketing.  From 1991 until joining the Company,  Dr.  Gallagher
was Vice  President  and  General  Manager  of Squibb  Diagnostics,  the in vivo
imaging  pharmaceutical  division.  Prior to that, Dr.  Gallagher served for ten
years with E.I. DuPont de Nemours & Co. in a variety of pharmaceutical research,
development, marketing and business management positions.


                                       3

<PAGE>


      Dr.  Agersborg has been a director of the Company since 1992 having served
as Chairman of the Board until March 10, 2000. Dr.  Agersborg also served as the
Company's Chief Executive  Officer and President until March 1994. Dr. Agersborg
serves  as  Chairman,   President  and  Chief  Scientific   Officer  of  Afferon
Corporation and Vice Chairman and Chief Scientific Officer of Maret Corporation,
having joined such companies in September 1992 and September 1994, respectively.
Dr.  Agersborg  has also  served as a  director  of Lidak  Pharmaceutical  since
October 1992. Each of such companies engages in pharmaceutical development. From
May 1987 until his retirement in June 1990,  Dr.  Agersborg was the President of
Wyeth-Ayerst Research Division of American Home Products  Corporation.  Prior to
that, and beginning in 1975, he was a Vice President, and then an Executive Vice
President of Wyeth-Ayerst Laboratories Research Division.

      Dr.  Barnett has been a director of the Company since  February 1997. He
is Chief  Operating  Officer of United  Dental Care,  Inc.,  a managed  dental
benefits firm,  where he has served in such capacity since January 1995.  From
August 1994 to January 1995, Dr. Barnett was Executive  Director of Prudential
DMO,  and  from  March  1993 to  August  1994,  he  served  as an  independent
consultant  in the managed care field.  From  January 1985 to March 1993,  Dr.
Barnett was a Senior Vice President with Pearle Vision, Inc.

      Mr. Black has been a director of the Company since  September,  1999. He
was President of the Zeneca Pharmaceuticals  Division of AstraZeneca,  Inc., a
pharmaceutical  company,  until  his  retirement  on July 1,  1999.  He joined
AstraZeneca,  Inc. in 1965 as a pharmaceutical  sales  representative and held
numerous  positions of increasing  responsibility in sales and marketing prior
to becoming President of the Zeneca Pharmaceuticals Division in 1991.

      Mr. Daverman has been a director of the Company since November 1995. He is
a managing  general  partner of Marquette  Venture  Partners,  a venture capital
investment  company  which he founded in 1987.  Mr.  Daverman  is  President  of
Marquette  Management  Partners,  LLC, the general partner of Marquette  Venture
Partners,  L.P.  and a general  partner of MG II, L.P.,  the general  partner of
Marquette  Venture  Partners II, L.P. and MVP II Affiliates  Fund,  L.P. He is a
member  of the  Board  of  Directors  of the  Technology  Advisory  Group of the
Technology  Management  Office of the University of Michigan.  Mr. Daverman is a
member of the Board of Directors  of  Endocardial  Solutions,  Inc. and numerous
privately  held  companies,  for all of  which  he  serves  on the  compensation
committee.

      Mr. Easton has been a director of the Company since  November  1993. He is
Managing  Director  of IBM  Healthcare  Consulting,  Inc.,  a major  health care
consulting  firm, where he has served in such capacity since 1981. Mr. Easton is
a former President of the Biomedical Marketing Association.

      Dr.  Winters  has been a director  of the  Company  since its  founding in
January  1992. He is a general  partner of Columbine  Venture  Funds,  a venture
capital fund, of which he was a founder in 1983. He also serves as a director of
Afferon Corporation, Maret Corporation and iPhysiciansNet, Inc. Dr Winters is on
the Compensation Committee of the Board of Directors of iPhysiciansNet, Inc.

      Mr. Kaplan has been a director of the Company since  September  1999. He
is a principal  and  portfolio  manager of Oaktree  Capital  Management,  LLC,
which is the general  partner of OCM  Principal  Opportunities  Fund,  L.P., a
venture  capital  fund.  He has  held  such  positions  since  June  1995  and
November  1993,  respectively.  From November 1993 to May 1995 he was Managing
Director  of Trust  Company of The West.  Mr.  Kaplan  serves as a director of
Acorn  Products,  Inc.,  Biopure  Corporation,   Cherokee  International  LLC,
Geologistics  Corporation,  KinderCare Learning Center Inc. and Roller Bearing
Holding Company, Inc.

      Pursuant  to  the  terms  of the  Company's  Certificate  of  Designation,
Preferences and Rights of Series D Cumulative  Convertible  Preferred Stock, the
holders of the Series D  Preferred  Stock,  acting as a single  class,  have the
right to designate and elect one member of the Board of Directors.  Such holders
have exercised such right by designating  Mr. Kaplan to serve as a member of the
Board of Directors.

      All  directors   will  hold  office  until  the  next  annual  meeting  of
Stockholders  and until  their  successors  shall  have been  duly  elected  and
qualified.  None of the Company's directors are related to any other director or
to any executive officer of the Company.


                                       4

<PAGE>


      THE BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS,  AS APPLICABLE,  VOTE
FOR EACH OF THE NOMINEES FOR THE BOARD OF DIRECTORS.


Committees and Meetings of the Board
- ------------------------------------

      The  Board  of  Directors  has a  Compensation  Committee  which  approves
salaries and incentive  compensation  for executive  officers of the Company and
which  administers the Company's stock option plans, an Audit  Committee,  which
reviews the results  and scope of the audit and other  services  provided by the
Company's independent accountants, and a Nominating Committee, which reviews and
nominates  candidates for election to the Board of Directors.  The  Compensation
Committee currently consists of Robert J. Easton,  Stephen W. Ritterbush,  Ph.D.
and Terence E. Winters,  Ph.D.  The  Compensation  Committee was  established in
March 1996 and held two meetings in 1999. The Audit Committee currently consists
of James E. Daverman,  Stephen W. Ritterbush,  Ph.D. and Stephen A. Kaplan.  The
Audit  Committee was established in March 1996 and held one meeting in 1999. Dr.
Ritterbush  is not  standing  for  re-election  to the Board of  Directors  and,
accordingly, will not serve on either of the Compensation Committee or the Audit
Committee subsequent to the Meeting. The Board of Directors intends to appoint a
replacement  member to each such  committee in a timely  manner.  The Nominating
Committee  was  established  in March 2000 and  currently  consists of Robert C.
Black,  who serves as Chairman,  Peter R.  Barnett and Stephen A. Kaplan.  There
were four  meetings  of the  Board of  Directors  during  1999.  Each  incumbent
director  attended at least 75% of the aggregate of all meetings of the Board of
Directors  held during the period in which he served as a director and the total
number of meetings  held by the  committee on which he served during the period,
if applicable.


Compensation of Directors
- -------------------------

      Helmer  P.K.  Agersborg  was  paid  $36,000  in 1999 for his  services  as
Chairman of the Board. Peter R. Barnett and Robert C. Black each receives $1,500
per meeting for each meeting of the Board of Directors attended.  IBM Healthcare
Consulting,  Inc.  receives  $1,500 per meeting for each meeting of the Board of
Directors  attended by Mr. Easton.  No other directors receive cash compensation
for services on the Board of Directors.  The Company  provides  reimbursement to
directors for  reasonable  and necessary  expenses  incurred in connection  with
attendance at meetings of the Board of Directors and other Company business.

      From  time-to-time,  members of the Board of  Directors  have been granted
options  to  purchase  shares  of Common  Stock of the  Company.  See  "SECURITY
OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT."

      Pursuant to the Company's  1996  Non-Employee  Director  Stock Option Plan
(the  "Non-Employee  Plan"),  each new  non-employee  director of the Company is
automatically granted an option to purchase 25,000 shares of Common Stock, at an
exercise  price per share equal to the then current fair market value per share.
All such options become exercisable in five equal annual installments commencing
one year  after the date of grant  provided  that the  optionee  then  remains a
director  at the time of  vesting  of the  installments.  The right to  exercise
annual  installments  of  options  under the  Non-Employee  Plan will be reduced
proportionately based on the optionee's actual attendance at Directors' meetings
if the optionee fails to attend at least 75% of the Directors'  meetings held in
any calendar year. On January 15, 1999, Dr. Gallagher was granted 75,000 options
outside of any stock option plan at an exercise price of $10.0625 per share. All
of such options become exercisable in five equal annual  installments  beginning
on the first anniversary of such grant date.


                                       5

<PAGE>


                               EXECUTIVE OFFICERS

      The  following  table  identifies  the current  executive  officers of the
Company:


                                          Capacities in        In Current
Name                             Age      Which Served        Position Since
- ----                             ---      ------------        --------------

Brian M. Gallagher, Ph.D.....    52       President, Chief    April 1994
                                          Executive Officer   (Director since
                                          and Chairman of     November 1994 and
                                          the Board           Chairman since
                                                              March 2000)

Robert A. Ashley(1)..........   42       Senior Vice          January 1999
                                         President

Nancy C. Broadbent(2)........   44       Chief Financial      March 1996
                                         Officer, Treasurer
                                         and Secretary

Douglas C. Gehrig(3).........   55       Vice President,      June 1997
                                         Sales

David P. Pfeiffer(4).........   37       Vice President,      June 1997
                                         Marketing
- -----------

(1)   Mr.  Ashley  joined  the  Company  in  September  1994 as Vice  President,
      Commercial  Development.  He was  promoted  to Senior  Vice  President  in
      January  1999.  From 1989 until  joining the  Company,  he was employed by
      Bristol-Myers Squibb Company and its predecessor,  Squibb Corporation,  in
      various positions including product  development,  commercial and business
      development and, most recently, as Director, Business Development where he
      was  responsible  for the  worldwide  product  and market  development  of
      several new drugs. From 1979 to 1989, Mr. Ashley held various positions at
      Amersham   International  (UK)  Ltd.,  including  research,   development,
      manufacturing, sales and marketing positions, as well as worldwide product
      development and product launch positions.

(2)   Ms. Broadbent joined the Company in March 1996 as Chief Financial Officer,
      Treasurer and Secretary.  From October 1994 until joining the Company, Ms.
      Broadbent  served as Senior Vice President,  Chief  Financial  Officer and
      director of Human Genome Sciences,  Inc., a pharmaceuticals  company. From
      January  1993 to  October  1994,  she served as Vice  President  and Chief
      Financial  Officer of Cangene,  Inc., a  biopharmaceutical  company.  From
      January 1992 through December 1992, Ms. Broadbent served as an independent
      financial  consultant.  From March 1990 to December 1991, she was employed
      by Baring  Brothers & Co.,  Inc.,  initially as Senior Vice  President and
      then  as  Executive  Director,  Corporate  Finance.  Prior  to  that,  Ms.
      Broadbent  served  for nine  years in  corporate  finance  positions  with
      Salomon Brothers, Inc. and PaineWebber Incorporated.

(3)   Mr. Gehrig joined the Company in June 1997 as Vice President,  Sales. From
      September  1991  until  joining  the  Company,  he  was  employed  by  the
      Musculoskeletal  Transplant  Foundation,  most recently as Vice President,
      Hospital  Sales.  From January 1990 until  September  1991, Mr. Gehrig was
      Director of Sales for the  Consumer  Product  Division of Warner  Lambert.
      Prior to that,  he served for 19 years in  various  sales,  marketing  and
      sales management positions with Johnson & Johnson.

(4)   Mr. Pfeiffer joined the Company in June 1997 as Vice President, Marketing.
      From September 1995 until June 1997,  Mr.  Pfeiffer  served as Director of
      Marketing,  Health Management Services,  for SmithKline Beecham.  From May
      1994  to  September  1995,  Mr.  Pfeiffer  served  as  Director,   Disease
      Management Services of Stuart Disease Management  Services,  a division of
      Zeneca  Pharmaceuticals.  From October 1991 to May 1994 he was employed in
      various product management  positions with Zeneca  Pharmaceuticals  Group.
      From July 1988 to October 1991,  Mr.  Pfeiffer held various  marketing and
      product  management  positions with the Lederle  Laboratories  Division of
      American Cyanamid.


                                       6

<PAGE>

      None of the Company's executive officers is related to any other executive
officer or to any director of the Company. Executive officers of the Company are
elected  annually by the Board of Directors and serve until their successors are
duly elected and qualified.


Section 16(a) Beneficial Ownership Reporting Compliance
- -------------------------------------------------------

      Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended (the
"Exchange Act"), requires the Company's directors, officers and stockholders who
beneficially own more than 10% of any class of equity  securities of the Company
registered pursuant to Section 12 of the Exchange Act to file initial reports of
ownership  and reports of changes in  ownership  with  respect to the  Company's
equity securities with the Securities and Exchange  Commission (the "SEC").  All
reporting  persons are  required by SEC  regulation  to furnish the Company with
copies of all reports that such reporting  persons file with the SEC pursuant to
Section 16(a).

      Based solely on the Company's  review of the copies of such forms received
by the Company  and upon  written  representations  of the  Company's  reporting
persons received by the Company,  except as described below, each such reporting
person has filed all of their respective  reports pursuant to Section 16(a) on a
timely  basis.  Each of Marquette  Venture  Partners II, L.P., a 10%  beneficial
owner,  and MVP II Affiliated  Fund,  L.P., a 10%  beneficial  owner,  failed to
timely file a Form 4 for  transactions  occurring on May 12, 1999 with regard to
their respective  acquisitions of the Company's  Series D Preferred Stock.  Such
Forms 4 were filed on August 18, 1999.  Robert J. Easton, a director,  failed to
timely file a Form 4 related to his  acquisition of Series D Preferred  Stock on
May 12,  1999,  for which he filed a Form 4 on  September  14,  1999.  Marquette
General II L.P.  Fund, a 10%  beneficial  owner,  failed to timely file a Form 4
related to its  disposition of shares of the Company's  Common Stock on December
23, 1999, for which it filed a Form 4 on January 20, 2000.  Stephen A. Kaplan, a
director  and 10%  beneficial  owner  failed to  timely  file a Form 3 - Initial
Statement of Beneficial  Ownership of Securities  upon his election to the Board
of  Directors of the Company on  September  10,  1999.  Such Form 3 was filed on
October 7, 1999.


                                       7

<PAGE>


                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal 1999, 1998 and 1997
- -----------------------------------------------------

      The following Summary Compensation Table sets forth information concerning
compensation  for services in all  capacities  awarded to,  earned by or paid to
each  person who served as the  Company's  Chief  Executive  Officer at any time
during 1999 and each other executive officer of the Company whose aggregate cash
compensation  exceeded  $100,000  at the end of 1999  (collectively,  the "Named
Executives") during the years ended December 31, 1999, 1998 and 1997.

<TABLE>
<CAPTION>

                                                 SUMMARY COMPENSATION TABLE(1)

- ----------------------------------------------------------------------------------------------------------------------------------
                                                                                         Long-Term Compensation
                                                            Annual Compensation                 Awards

                                                 -------------------------------------   ----------------------
                                                                                              Securities
                                                       Salary                Bonus            Underlying               All Other
    Name and Principal Position         Year                                                    Options              Compensation
                                                        ($)                   ($)                  (#)                    ($)
                (a)                     (b)             (c)                   (d)                  (g)                    (i)
- ------------------------------------ ----------- ------------------- -----------------   ----------------------      -------------

<S>                                   <C>            <C>                    <C>                <C>                   <C>
Brian M. Gallagher, Ph.D.(2)........  1999           268,000                81,021             75,000                       --
 President and Chief                  1998           262,500                53,074             75,000                       --
 Executive Officer                    1997           250,000                42,536             50,000                       --

Robert A. Ashley....................  1999           190,000                63,542             35,000                       --
 Senior Vice President                1998           175,000                36,701             25,000                       --
                                      1997           157,500                36,125             25,000                       --

Nancy C. Broadbent..................  1999           186,000                43,916             25,000                       --
  Chief Financial Officer,            1998           182,000                36,789             25,000                       --
  Treasurer and Secretary             1997           173,250                31,380             25,000                       --

Douglas C. Gehrig(3)................  1999           157,000                43,021             25,000                       --
 Vice President, Sales                1998           153,500                36,413             20,000                       --
                                      1997            78,977                   800             60,000                       --

David F. Pfeiffer(4)................  1999           157,000                43,263             25,000                       --
 Vice President, Marketing            1998           153,500                36,544             20,000                   35,000(5)
                                      1997            84,375                   656             60,000                       --
</TABLE>
- -----------

(1)   The  costs of  certain  benefits  are not  included  because  they did not
      exceed, in the case of each Named Executive,  the lesser of $50,000 or 10%
      of the total annual salary and bonus reported in the above table.

(2)   In November 1994, Dr. Gallagher  purchased 125,000 shares of the Company's
      restricted  Common Stock at $0.335 per share.  Such shares were subject to
      the Company's  right of first  refusal,  pursuant to which the Company was
      permitted to buy such shares back from Dr.  Gallagher at $0.335 per share,
      if Dr.  Gallagher was terminated for cause, and at the then current market
      value per share,  if he was  terminated  for any other reason.  On May 11,
      1999,  the Board of  Directors  unanimously  voted to remove  the right of
      first refusal  restriction from the 125,000 shares.  At December 31, 1999,
      Dr. Gallagher held all of such restricted shares, with a year-end value of
      $3,083,125  based on the value of the Common Stock as of such date ($25.00
      per share), less the purchase price per share paid for such shares ($0.335
      per share).

(3)   Mr. Gehrig joined the Company in June 1997 as Vice President, Sales.

(4)   Mr. Pfeiffer joined the Company in June 1997 as Vice President, Marketing.

(5)   Represents reimbursable relocation allowance.


                                       8

<PAGE>


Option Grants in 1999
- ---------------------

      The following table sets forth information concerning individual grants of
stock options made during 1999 to each of the Named Executives.


<TABLE>
<CAPTION>
                        OPTION GRANTS IN LAST FISCAL YEAR

- ------------------------------------------------------------------------------------------- ---------------------------
                                       Individual Grants

                                                                                            ---------------------------
- -------------------------------- --------------- ------------- ------------- -------------- ---------------------------
                                                                                               Potential Realizable
                                                  Percent of                                         Value at
                                   Number of        Total                                    Assumed Annual Rates of
                                   Securities      Options                                            Stock
                                   Underlying     Granted to   Exercise or                    Price Appreciation for
                                    Options       Employees     Base Price                            Option
                                    Granted       in Fiscal                   Expiration             Term (3)
                                                                                            ---------------------------
             Name                    (#)(1)        Year (2)       ($/Sh)         Date           5%($)         10%($)
              (a)                     (b)            (c)           (d)            (e)            (f)           (g)
- -------------------------------- --------------- ------------- ------------- -------------- --------------- -----------

<S>                                  <C>              <C>         <C>           <C>            <C>          <C>
Brian M. Gallagher, Ph.D........     75,000(3)        15.8%        $10.63       1/15/09      474,642        1,202,837

Robert A. Ashley................     35,000(3)         7.4%        $10.63       1/15/09      221,500          561,324

Nancy C. Broadbent..............     25,000(3)         5.3%        $10.63       1/15/09      158,214          400,946

Douglas C. Gehrig...............     25,000(3)         5.3%        $10.63       1/15/09      158,214          400,946

David F. Pfeiffer...............     25,000(3)         5.3%        $10.63       1/15/09      158,214          400,946

</TABLE>
- -----------

(1)   Based on an  aggregate  of 475,150  options  granted to employees in 1999,
      including options granted to Named Executives.

(2)   Based on a grant date fair market value of $10.063 per share.

(3)   Such options were issued outside of any  stock option plan.


                                       9

<PAGE>


Aggregated Option Exercises in 1999 and Year End Option Values
- --------------------------------------------------------------

      The following  table sets forth  information  concerning  each exercise of
options  during 1999 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.

<TABLE>
<CAPTION>

                                      AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                                             AND FISCAL YEAR END OPTION VALUES

- -------------------------------------------------------------------------------------------------------------------------
                                                                                Number of
                                                                          Securities Underlying            Value of
                                                                               Unexercised               Unexercised
                                                                                Options at               In-the-Money
                                                                                  Fiscal                  Options at
                                                                                 Year-End                   Fiscal
                                         Shares                                    (#)                     Year-End
                                       Acquired on           Value             Exercisable/                ($) (1)
                                        Exercise           Realized           Unexercisable              Exercisable/
               Name                        (#)                ($)                  (d)                  Unexercisable
               (a)                         (b)                (c)                                            (e)
- --------------------------------    ------------------ ------------------ -------------------      ----------------------
<S>                                         <C>            <C>            <C>                      <C>
Brian M. Gallagher, Ph.D........            --             --             135,000/165,000          $3,024,500/$2,725,275

Robert A. Ashley................            --             --              61,875/70,000           $1,377,484/$1,137,795

Nancy C. Broadbent..............            --             --              39,000/72,000           $  805,750/$1,264,425

Douglas L. Gehrig...............            --             --              40,000/65,000           $  592,500/$1,018,425

David P. Pfeiffer...............            --             --              40,000/65,000           $  592,500/$1,018,425

</TABLE>
- -----------

(1)   Based on a year end fair market value of the underlying  securities  equal
      to $25.00 per share, less the exercise price payable for such shares.


Employment   Contracts,   Termination   of  Employment   and   Change-in-Control
Arrangements
- --------------------------------------------------------------------------------

      The  Company  has  executed  indemnification  agreements  with each of its
executive  officers  and  directors  pursuant to which the Company has agreed to
indemnify such parties to the full extent  permitted by law,  subject to certain
exceptions,  if such party becomes  subject to an action because such party is a
director,  officer, employee, agent or fiduciary of the Company. In general, the
Company's employees are covered by confidentiality agreements.

      In addition,  each of Dr.  Gallagher,  Ms.  Broadbent and Messrs.  Ashley,
Gehrig and  Pfeiffer  have agreed that during the term of his or her  employment
and for a period of two years  thereafter,  such  person  will not  directly  or
indirectly provide services to or for any business engaged in research regarding
the  development,   manufacture,  testing,  marketing  or  sale  of  collagenase
inhibiting drugs for application in periodontal disease or any other application
which, during the period of such person's employment with the Company, is either
marketed or in advanced clinical development by the Company.


Compensation Committee Interlocks and Insider Participation
- -----------------------------------------------------------

      The  Compensation   Committee  currently  consists  of,  and  during  1999
consisted  of, Robert J. Easton,  Stephen W.  Ritterbush,  Ph.D.  and Terence E.
Winters,  Ph.D. Dr.  Ritterbush is not standing for  re-election to the Board of
Directors  and,  accordingly,  will  not  serve  on the  Compensation  Committee
subsequent  to the  Meeting.  The


                                       10

<PAGE>


Board of Directors intends to appoint a replacement  member to such committee in
a timely  manner.  There are no,  and during  1999  there were no,  Compensation
Committee Interlocks.

      As of April 1, 2000, Columbine Venture Fund II, L.P. and Columbine Venture
Management II, L.P., with which Dr. Winters is affiliated,  held an aggregate of
713,446 shares of the Company's  Common Stock which were issued upon  conversion
of certain  shares of the  Company's  Series A, Series B or Series C  Redeemable
Preferred Stock previously held by such entities.  Mr. Easton, in his individual
capacity, held 2,000 shares of the Company's Series D Preferred Stock which were
convertible  into 18,182 shares of Common Stock as of such date. All such shares
of Common Stock are entitled to certain  registration  rights or have previously
been registered by the Company and are entitled to certain rights to participate
in certain future offerings undertaken by the Company as set forth below.

      In  September  1995,  the  Company and the then  holders of the  Company's
Series A,  Series B and  Series C  Redeemable  Preferred  Stock  entered  into a
Registration  Rights  Agreement (the "Rights  Agreement")  pursuant to which the
Company has granted certain  registration rights to such Stockholders.  Pursuant
to the Rights  Agreement,  at any time beginning six months after June 20, 1996,
the effective date of the Company's  initial public offering,  the holders of at
least a majority of the Common Stock issued upon the conversion of the Series A,
Series B and Series C Redeemable Preferred Stock (the "Registrable  Securities")
have the  right,  subject  to  certain  restrictions  set  forth  in the  Rights
Agreement,  to require  that the Company  register  the  Registrable  Securities
requested  by  such  holders  at the  Company's  expense  (on no more  than  two
occasions)  on either a Form S-1,  Form S-2 or Form S-3  Registration  Statement
under the Securities Act of 1933, as amended (the "Securities Act"). The Company
is not,  however,  required to register any Registrable  Securities  unless such
shares  represent  at least 10% of the  Company's  outstanding  shares of Common
Stock, or, if less than 10%, if the anticipated aggregate offering price exceeds
$1,000,000.

      The holders of Registrable  Securities also have the right to an unlimited
number of  registrations  on Form S-3 under the  Securities  Act. The Company is
not,  however,  required to effect  such a  registration  unless the  requesting
holders reasonably  anticipate having an aggregate disposition price of at least
$500,000.

      Also  pursuant  to the  Rights  Agreement,  if,  at any  time  during  the
seven-year  period  commencing  on the effective  date of the Company's  initial
public offering,  the Company proposes to register any of its Common Stock under
the  Securities  Act for sale to the  public,  the  holders  of the  Registrable
Securities  have  unlimited  piggyback  registration  rights  at  the  Company's
expense, subject to certain restrictions set forth in the Rights Agreement.

      Also in September  1995, the Company granted to the then holders of Series
A,  Series  B  and  Series  C  Redeemable  Preferred  Stock  certain  rights  to
participate in certain future offerings  undertaken by the Company.  Such rights
to participate require that, with certain exceptions including,  but not limited
to, an underwritten  public  offering,  any time the Company  proposes to issue,
sell or exchange,  or reserve therefor,  any securities,  the Company must first
offer to sell to each of the  pre-conversion  holders of Series A,  Series B and
Series C  Redeemable  Preferred  Stock their  respective  pro rata share of such
securities  at a price  and on terms  identical  to the  price  and terms of the
securities proposed to be issued, sold or exchanged in the applicable offering.

      In May 1999,  the Company and the holders of the Series D Preferred  Stock
entered into a Stockholder  and  Registration  Rights  Agreement  (the "Series D
Rights   Agreement")   pursuant  to  which,  among  other  things,  the  Company
registered,  on a  Registration  Statement  on a Form S-3,  all of the shares of
Common Stock  underlying the shares of Series D Preferred  Stock then issued and
outstanding.  The Series D Rights  Agreement  further  obligates  the Company to
register,  on a Registration  Statement on Form S-3, all of the shares of Common
Stock issued,  or to be issued,  as dividends on the Series D Preferred Stock to
the  holders  thereof  and  within a  reasonable  period of time after each such
dividend  payment is made.  The Company is  obligated  to keep current each such
Registration  Statement  on Form S-3  until  such  time as all of the  shares of
Common Stock  registered  thereunder have been sold or are otherwise exempt from
registration.

      The holders of at least a majority  of the Series D  Preferred  Stock also
have the right,  subject  to certain  restrictions,  to require  the  Company to
register the shares of Common Stock underlying their Series D Preferred


                                       11

<PAGE>


Stock on a Registration  Statement on Form S-1 at the Company's  expenses (on no
more than 2 occasions).  Also, pursuant to the Series D Rights Agreement, if the
Company  proposes to register any of its securities  under the Securities Act of
1933, as amended,  for sale to the public, the holders of the Series D Preferred
Stock have certain piggyback  registration  rights with respect to the shares of
Common Stock underlying their Series D Preferred Stock at the Company's expense,
subject to certain restrictions. In addition, if the Company grants registration
rights to the holders of any  security of the  Company  that are more  favorable
than the registration  rights granted under the Series D Rights Agreement,  then
the holders of the Series D Preferred Stock shall be deemed to have been granted
such superior  registration  rights as well with respect to the shares of Common
Stock underlying  their Series D Preferred Stock.  Also pursuant to the terms of
the Series D Rights  Agreement,  the  holders of Series D  Preferred  Stock have
certain  rights of first refusal with respect to certain stock  issuances by the
Company,  beginning  twelve  months  after the date of initial  issuance  of the
Series D Preferred Stock.


                                       12

<PAGE>


Performance Graph
- -----------------

      The following graph compares the cumulative  total  Stockholder  return on
the  Company's  Common  Stock  with the  cumulative  total  return on the Nasdaq
Composite Index and the Nasdaq  Pharmaceutical Index  (capitalization  weighted)
for the  period  beginning  on the date on which  the  Securities  and  Exchange
Commission  declared  effective the Company's  Form 8-A  Registration  Statement
pursuant  to  Section 12 of the  Exchange  Act and ending on the last day of the
Company's last completed fiscal year.

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

              Among the Company, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)


                                  [ Graphic ]






<TABLE>
<CAPTION>

     Company/      Base Period    December      June    December       June       December      June      December
    Index Name      June 1996      1996         1997      1997         1998         1998        1999        1999

<S>                   <C>         <C>         <C>       <C>           <C>         <C>          <C>         <C>
CGPI............      $100        $ 89.04     $131.51   $136.99       $ 94.52     $105.48      $109.59     $273.97
NASDAQ..........      $100        $110.46     $123.67   $135.61       $162.98     $190.29      $234.00     $353.10
NASDAQ PHAR.....      $100        $ 98.41     $101.11   $101.87       $104.04     $130.72      $145.19     $241.69

</TABLE>
- -----------

(1)   Graph  assumes  $100  invested  on June 20, 1996 in the  Company's  Common
      Stock,  the Nasdaq  Composite  Index and the Nasdaq  Pharmaceutical  Index
      (capitalization weighted).

(2)   Total return assumes reinvestment of dividends.

(3)   Year ended December 31.


                                       13

<PAGE>


Compensation Committee Report on Executive Compensation
- -------------------------------------------------------

      The Compensation Committee has furnished the following report:

      The Compensation  Committee is composed of three  non-employee  directors.
The  Compensation  Committee  recommends,  and the Board  approves,  all matters
relating to executive compensation, including setting and administering policies
governing executive salaries, bonuses (if any) and stock option awards (if any).
The  Compensation  Committee meets twice annually to set performance  objectives
for the Chief Executive Officer ("CEO") and to determine the annual compensation
of the CEO and other senior  executives  of the Company.  The CEO is not present
during the discussion of his compensation.

EXECUTIVE COMPENSATION POLICY

      The goal of the Company's executive  compensation policy is to ensure that
an  appropriate  relationship  exists  between  executive  compensation  and the
creation of stockholder  value,  while at the same time attracting and retaining
qualified senior management.  In order to continually  attract and retain highly
experienced   executives,   the  Company's   compensation  packages  for  senior
executives  are  highly  competitive  with  those  paid to  executives  of other
emerging pharmaceutical companies.

COMPENSATION MIX

      The Company's  executive  compensation  packages  generally  include three
components: base salary, a discretionary annual cash bonus and stock options.

BASE SALARY

      The  Compensation  Committee  seeks to  establish  base  salaries for each
position  and  level of  responsibility  which  are  competitive  with  those of
executive officers at other emerging pharmaceutical companies.

DISCRETIONARY CASH BONUS

      The Compensation  Committee  believes that  discretionary cash bonuses are
important to motivate and reward executive officers.  However,  cash bonuses are
not  guaranteed.  Annual cash bonuses are awarded to  executives  based on their
achievements  against a stated list of objectives  developed at the beginning of
each year by senior management and the Compensation  Committee.  Such objectives
are reviewed and approved by the Board of Directors.

STOCK OPTIONS

      Stock option grants under the Company's stock option plans are designed to
align the long term  interests  of the  Company's  executives  with those of its
Stockholders  by rewarding  executives for  increasing  stockholder  value.  All
executive  officers are awarded option grants upon joining the Company which are
competitive  with those at  comparable  emerging  pharmaceutical  companies.  In
addition,  the  Compensation  Committee may award additional stock option grants
annually.  When granting stock options, the Compensation Committee considers the
recommendation  of the  Company's  Chief  Executive  Officer  and  the  relative
performance and contributions of each officer compared to that of other officers
within the Company with similar levels of responsibility.

COMPENSATION OF THE CHIEF EXECUTIVE OFFICER

      In establishing Dr.  Gallagher's  compensation  package,  the Compensation
Committee  seeks  to  maintain  a level of total  current  compensation  that is
competitive  with  that paid to chief  executive  officers  of other  comparable
emerging   pharmaceutical   companies.  In  addition,  in  order  to  align  Dr.
Gallagher's  interests  with the  interests of the Company's  Stockholders,  the
Compensation  Committee  attempts to make a substantial  portion of the value of
his total  compensation  dependent on the  appreciation  of the Company's  stock
price.


                                       14

<PAGE>


      Dr.  Gallagher's  performance  is evaluated  annually by the  Compensation
Committee  against a stated  list of  short,  medium  and long  term  objectives
developed  by the  Compensation  Committee  at the  beginning  of each  year and
approved by the Board of Directors.  Based on his achievements relating to these
objectives,  the Compensation Committee  recommended,  and the Board approved, a
bonus to Dr.  Gallagher  of  $135,000  for 1999,  which is paid in 2000,  and an
increase in base salary from $268,000 to $300,000 effective January 1, 2000.

      Section 162(m) of the Internal Revenue Code disallows the deductibility by
the  Company of any  compensation  over $1 million  paid to the Chief  Executive
Officer  or any of the other four most  highly  compensated  executives,  unless
certain  criteria are satisfied.  The Company's Chief Executive  Officer and the
other named  executives have not received annual  compensation  over $1 million,
and the  Company has not  determined  what  measures,  if any, it should take to
comply with Section 162.

                                            Compensation Committee Members:

                                            Robert J. Easton
                                            Stephen W. Ritterbush, Ph.D.
                                            Terence E. Winters, Ph.D.


                                       15

<PAGE>


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      There were, as of February 15, 2000,  approximately  115 holders of record
and 3,400 beneficial  holders of the Company's Common Stock. The following table
sets forth  certain  information,  as of  February  15,  2000,  with  respect to
holdings of the Company's  capital stock by (i) each person known by the Company
to be the beneficial  owner of more than 5% of the total number of shares of the
capital stock outstanding as of such date, (ii) each of the Company's  directors
(which includes all nominees) and Named Executives,  and (iii) all directors and
officers as a group.

                                            Amount and Nature of      Percent
                                                Beneficial              of
Name and Address of Beneficial Owner(1)        Ownership(1)           Class(2)
- -----------------------------------------   --------------------      --------

(i)   Certain Beneficial Owners:

OCM Principal Opportunities Fund, L.P.
333 South Grand Avenue, 78th Floor
Los Angeles, California 90071............      1,662,630(3)             16.2%

Zesiger Capital Group LLC
320 Park Avenue, 30th Floor
New York, New York 10022.................        877,275                10.1

Columbine Venture Fund II, L.P. and
  Columbine Venture Management II, L.P.
6155 N. Scottsdale Road, Suite 100
Scottsdale, Arizona 85250................        713,446(4)              8.2

Marquette Venture Partners II, L.P.
  and MVP II Affiliates Fund, L.P.
520 Lake Cook Road, Suite 450
Deerfield, Illinois 60015................        984,795(5)             11.2

Thomson Horstmann & Bryant, Inc.
Park 80 West Plaza Two
Saddle Brook, NJ 07663...................        542,700                 6.3

(ii)  Directors (which includes all
      nominees) and Named Executives:

Brian M. Gallagher, Ph.D.................        520,000(6)              5.7
Robert A. Ashley.........................        190,100(7)              2.2
Nancy C. Broadbent.......................        151,000(8)              1.7
Douglas C. Gehrig........................        123,320(9)              1.4
David F. Pfeiffer........................        133,000(10)             1.5
Helmer P.K. Agersborg, Ph.D..............        131,209(11)             1.5
Peter R. Barnett, D.M.D..................         17,000(12)              *
Robert Black.............................             --                  *
James E. Daverman........................      1,019,795(13)            11.6
Robert J. Easton.........................         66,083(14)              *
Stephen Kaplan...........................      1,665,630(15)            16.2
Stephen W. Ritterbush, Ph.D..............         18,100(16)              *
Terence E. Winters, Ph.D.................        728,446(17)             8.4

(iii) All Directors and officers as a
      group (13 persons).................      4,763,683 (18)           41.7%

- -----------

*     Less than 1%

(1)   Except  as set  forth  in the  footnotes  to this  table  and  subject  to
      applicable  community  property law, the persons and entities named in the
      table have sole voting and investment power with respect to all shares.


                                       16

<PAGE>


(2)   Applicable  percentage  of ownership for each holder is based on 8,665,729
      shares of Common Stock  outstanding on February 15, 2000,  plus any Common
      Stock equivalents and presently exercisable stock options or warrants held
      by each such  holder,  and  options or  warrants  held by each such holder
      which will become exercisable within 60 days after February 15, 2000.

(3)   Includes  1,609,091 shares of Common Stock issuable upon the conversion of
      177,000 shares the Series D Preferred Stock held thereby and 53,539 shares
      of Common  Stock  issued in payment of dividends on the Series D Preferred
      Stock.

(4)   Includes 654,082 shares and 59,364 shares owned by Columbine  Venture Fund
      II, L.P. and Columbine Venture Management II, L.P., respectively.

(5)   Includes  an  aggregate  of  982,183  shares  owned by  Marquette  Venture
      Partners II, L.P.  (which  includes 88,382 shares of Common Stock issuable
      upon the  conversion of 9,722 shares of the Series D Preferred  Stock held
      thereby,  2,941  shares of Common  Stock issued in payment of dividends on
      the Series D Preferred  Stock and 890,860 shares of Common Stock otherwise
      held thereby), and an aggregate of 2,612 shares owned by MVP II Affiliates
      Fund,  L.P (which  includes 2,527 shares of Common Stock issuable upon the
      conversion of 278 shares of the Series D Preferred Stock held thereby, and
      85 shares of Common  Stock  issued in payment of dividends on the Series D
      Preferred Stock).

(6)   Includes  395,000 shares of Common Stock  underlying  options which are or
      may be exercisable as of February 15, 2000 or 60 days after such date.

(7)   Includes  162,500 shares of Common Stock  underlying  options which are or
      may be exercisable as of February 15, 2000 or 60 days after such date.

(8)   Includes  136,000 shares of Common Stock  underlying  options which are or
      may be  exercisable  as of  February  15, 2000 or 60 days after such date.
      Also includes 1,000 shares held as custodian for minor child.

(9)   Includes  121,000 shares of Common Stock  underlying  options which are or
      may be exercisable as of February 15, 2000 or 60 days after such date.

(10)  Includes  131,000  shares of Common  Stock  underlying  options  which are
      exercisable as of February 15, 2000 or 60 days after such date.

(11)  Includes  42,500  shares  of Common  Stock  underlying  options  which are
      exercisable as of February 15, 2000 or 60 days after such date.

(12)  Includes  15,000 shares  underlying  options which are  exercisable  as of
      February 15, 2000 or 60 days after such date.

(13)  James E. Daverman is President of Marquette Management Partners,  LLC, the
      general partner of Marquette Venture Partners,  L.P. and a general partner
      of MG II, L.P., the general partner of Marquette Venture Partners II, L.P.
      and MVP II Affiliates  Fund,  L.P. and, as such,  has the power to vote or
      direct  the vote of and to dispose  of or direct  the  disposition  of the
      shares owned by Marquette  Venture Partners II, L.P. and MVP II Affiliates
      Fund, L.P. Mr. Daverman expressly disclaims  beneficial  ownership of such
      shares,  except as to his  proportionate  interest  in  Marquette  Venture
      Partners II, L.P. and MVP II Affiliates Fund, L.P.  Includes 15,000 shares
      of Common Stock  underlying  options which are  exercisable as of February
      15,  2000 or 60 days  after such date and  20,000  shares of Common  Stock
      otherwise held by Mr. Daverman, individually.

(14)  Includes  15,000  shares  of Common  Stock  underlying  options  which are
      exercisable  as of  February  15,  2000 or 60 days after  such date.  Also
      includes  18,182 shares of Common Stock  issuable  upon the  conversion of
      2,000  shares of the Series D Preferred  Stock held by Mr.  Easton and 606
      shares of Common  Stock  issued in  payment


                                       17

<PAGE>

      of dividends on the Series D Preferred  Stock.  Also includes 6,400 shares
      of Common Stock held as trustee for Second Easton Family  Charitable Trust
      and 25,895 shares of Common Stock otherwise held by Mr. Easton.

(15)  Stephen Kaplan is a principal of OCM Principal  Opportunities  Fund,  L.P.
      and,  as such,  has the power to vote or direct the vote of and to dispose
      of or  direct  the  disposition  of the  shares  owned  by  OCM  Principal
      Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly  disclaims   beneficial
      ownership of such shares,  except as to his proportionate  interest in OCM
      Principal  Opportunities  Fund, L.P. Includes 3,000 shares of Common Stock
      held by Mr. Kaplan in his individual capacity.

(16)  Includes  15,000  shares  of Common  Stock  underlying  options  which are
      exercisable  as of February 15, 2000 or 60 days after such date.  Includes
      2,186 shares of  restricted  Common  Stock and 914 shares of  unrestricted
      Common  Stock  held by Dr.  Ritterbush  in his  individual  capacity.  Dr.
      Ritterbush is not standing for re-election to the Board of Directors.

(17)  Terence E. Winters,  Ph.D. is a general partner of Columbine  Venture Fund
      II, L.P. and Columbine  Venture  Management II, L.P. and, as such, has the
      power  to vote or  direct  the vote of and to  dispose  of or  direct  the
      disposition of the shares owned by each such entity. Dr. Winters expressly
      disclaims  beneficial   ownership  of  such  shares,   except  as  to  his
      proportionate  interest in each such  entity.  Includes  15,000  shares of
      Common Stock  underlying  options which are exercisable as of February 15,
      2000 or 60 days after such date.

(18)  See Notes 6 through 17.


Series D Preferred Stock
- ------------------------

      There were,  as of February 15, 2000, 6 holders of record of the Company's
Series D Preferred Stock. The following table sets forth certain information, as
of February 15, 2000, with respect to the beneficial  ownership of the Company's
Series D  Preferred  Stock by (i) each  person  known by the  Company  to be the
beneficial  owner of more  than 5% of the  total  number  of  shares of Series D
Preferred  Stock  outstanding  as of  such  date,  (ii)  each  of the  Company's
directors  (which includes all nominees) and Named  Executives who  beneficially
own shares of Series D Preferred  Stock, and (iii) all directors and officers as
a group.

                                            Amount and Nature of      Percent
                                                Beneficial              of
Name and Address of Beneficial Owner(1)        Ownership(1)           Class(2)
- -----------------------------------------   --------------------      --------

(i)   Certain Beneficial Owners:

OCM Principal Opportunities Fund, L.P....        177,000(3)             88.5%
Richard A. Horstmann.....................         10,000(4)              5.0
Marquette Venture Partners II, L.P.
  and MVP II Affiliates Fund, L.P........         10,000(5)              5.0

(ii)  Directors (which includes all
      nominees) and Named Executives:

Robert J. Easton.........................          2,000(6)              1.0
Stephen Kaplan...........................        177,000(7)             88.5

(iii) All Directors and officers as a
      group (13 persons).................        199,000(6) (7)        99.5%

- -----------

(1)   Except  as set  forth  in the  footnotes  to this  table  and  subject  to
      applicable  community  property law, the persons and entities named in the
      table have sole voting and investment power with respect to all shares.

(2)   Applicable  percentage of ownership is based on 200,000 shares of Series D
      Preferred Stock outstanding on February 15, 2000.

(3)   Such shares of Series D Preferred  Stock are  convertible  into  1,609,091
      shares of Common Stock.

(4)   Such shares of Series D Preferred Stock are convertible into 90,909 shares
      of Common Stock.


                                       18

<PAGE>


(5)   Of such  shares of Series D  Preferred  Stock,  9,722  shares  are held by
      Marquette Venture Partners II, L.P. and are convertible into 88,382 shares
      of Common  Stock.  Also, of such shares of Series D Preferred  Stock,  278
      shares are held by MVP II Affiliates  Fund, L.P. and are convertible  into
      2,527 shares of Common Stock.

(6)   Such shares of Series D Preferred Stock are convertible into 18,182 shares
      of Common Stock.

(7)   Stephen Kaplan is a principal of OCM Principal  Opportunities  Fund,  L.P.
      and,  as such,  has the power to vote or direct the vote of and to dispose
      of or  direct  the  disposition  of the  shares  owned  by  OCM  Principal
      Opportunities  Fund,  L.P.  Mr.  Kaplan  expressly  disclaims   beneficial
      ownership of such shares,  except as to his proportionate  interest in OCM
      Principal Opportunities Fund, L.P.


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      For transactions and information  relating to certain  registration rights
and rights to participate in certain future offerings undertaken by the Company,
for each of Mr.  Easton and Drs.  Ritterbush  and Winters,  each a member of the
Company's  Compensation   Committee,   please  see  "EXECUTIVE   COMPENSATION  -
Compensation Committee Interlocks and Insider Participation."

      As of April 1, 2000,  Marquette  Venture Partners II, L.P., with which Mr.
Daverman is affiliated,  held 890,860 shares of the Company's Common Stock which
were  previously  issued upon  conversion  of the  Company's  Series A Preferred
Stock,  Series B Preferred Stock and Series C Preferred Stock previously held by
each such entity. Such entities are,  therefore,  with respect to such shares of
Common  Stock,  entitled  to the  identical  registration  rights  and rights to
participate  in  certain  future  offerings  undertaken  by the  Company  as are
Columbine Venture Fund II, L.P. and Columbine Venture  Management II, L.P., with
which Dr. Winters is affiliated.

      As of April 1, 2000, each of Marquette  Venture  Partners II, L.P. and MVP
II  Affiliates  Fund,  L.P.,  with which Mr.  Daverman  is  affiliated,  and OCM
Principal  Opportunities  Fund, L.P., with which Mr. Kaplan is affiliated,  held
9,722,  278 and  177,000  shares  of the  Company's  Series D  Preferred  Stock,
respectively.  Such  entities  are,  therefore,  with  respect to such shares of
Series D Preferred Stock,  entitled to identical  registration rights and rights
of participation as is Robert Easton.

      In April 1998 and February 1999 the Company loaned to Robert  Ashley,  its
Senior Vice President, $56,195 and $10,000,  respectively. All such amounts were
repaid by Mr. Ashley to the Company in March 2000, with accrued interest thereon
at an annual rate of 6.58%.


               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

      The Board of  Directors  of the Company  intends,  subject to  Stockholder
approval, to retain KPMG LLP as independent auditors of the Company for the year
ending  December 31, 2000.  KPMG LLP also served as independent  auditors of the
Company  for 1999.  Neither  the firm nor any of its  members  has any direct or
indirect financial interest in the Company.

      THE  BOARD OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF KPMG LLP AS THE INDEPENDENT  AUDITORS OF THE COMPANY FOR THE YEAR
ENDING DECEMBER 31, 2000.

      One or more  representatives of KPMG LLP is expected to attend the Meeting
and have an  opportunity  to make a  statement  and/or  respond  to  appropriate
questions from Stockholders.


                                       19

<PAGE>


                             STOCKHOLDERS' PROPOSALS

      Proposals  of  Stockholders  intended to be  presented  at the 2001 Annual
Meeting of Stockholders must be received by the Company no later than January 8,
2001 to be  included in the  Company's  2001 Proxy  Statement  and form of proxy
relating to that meeting.  Stockholders  who intend to present a proposal at the
2001 Annual Meeting of  Stockholders  without  inclusion of such proposal to the
Company's  2001 proxy  materials are required to provide notice of such proposal
to the Company no later than March 24, 2001.  The Company  reserves the right to
reject,  rule out of order, or take other appropriate action with respect to any
proposal that does not comply with these other applicable requirements.


                                  OTHER MATTERS

      The Board of  Directors  is not aware of any  matter to be  presented  for
action at the  Meeting  other than the  matters  referred  to above and does not
intend to bring any other matters before the Meeting.  However, if other matters
should come before the Meeting,  it is intended that holders of the proxies will
vote thereon in their discretion.


                                     GENERAL

      The  accompanying  proxy is  solicited  by and on  behalf  of the Board of
Directors  of the  Company,  whose  notice of meeting is  attached to this Proxy
Statement,  and the  entire  cost  of such  solicitation  will be  borne  by the
Company.

      In addition to the use of the mails,  proxies may be solicited by personal
interview,  telephone and telegram by directors, officers and other employees of
the  Company  who will not be  specially  compensated  for these  services.  The
Company  will  also  request  that  brokers,  nominees,   custodians  and  other
fiduciaries forward soliciting materials to the beneficial owners of shares held
of record by such  brokers,  nominees,  custodians  and other  fiduciaries.  The
Company will reimburse such persons for their reasonable  expenses in connection
therewith.

      Certain  information  contained  in this Proxy  Statement  relating to the
occupations  and security  holdings of directors  and officers of the Company is
based upon information received from the individual directors and officers.

      COLLAGENEX  PHARMACEUTICALS,  INC. WILL FURNISH, WITHOUT CHARGE, A COPY OF
ITS  REPORT  ON FORM  10-K FOR THE  YEAR  ENDED  DECEMBER  31,  1999,  INCLUDING
CONSOLIDATED  FINANCIAL  STATEMENTS  AND  SCHEDULE  THERETO  BUT  NOT  INCLUDING
EXHIBITS,  TO EACH OF ITS  STOCKHOLDERS  OF RECORD ON APRIL 5, 2000, AND TO EACH
BENEFICIAL  STOCKHOLDER  ON THAT DATE UPON WRITTEN  REQUEST MADE TO MS. NANCY C.
BROADBENT, SECRETARY, COLLAGENEX PHARMACEUTICALS,  INC., 301 SOUTH STATE STREET,
NEWTOWN,  PENNSYLVANIA  18940.  A  REASONABLE  FEE WILL BE CHARGED FOR COPIES OF
REQUESTED EXHIBITS.

      PLEASE DATE,  SIGN AND RETURN THE PROXY CARD AT YOUR EARLIEST  CONVENIENCE
IN THE  ENCLOSED  RETURN  ENVELOPE.  A PROMPT  RETURN OF YOUR PROXY CARD WILL BE
APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.

                                       By Order of the Board of Directors

                                       /s/ Nancy C. Broadbent,
                                           Secretary

Newtown, Pennsylvania
April 14, 2000


                                       20

<PAGE>
                                                                      Appendix A



                                  COMMON STOCK

                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

      The undersigned hereby constitutes and appoints Brian M. Gallagher,  Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of  Stockholders  of the Company to be held at the Marriott  Hotel,  1201 Market
Street,  Philadelphia,  Pennsylvania at 8:30 A.M., local time, on Monday, May 8,
2000,  and at any  adjournment  or  adjournments  thereof,  upon  the  following
proposals more fully  described in the Notice of Annual Meeting of  Stockholders
and Proxy Statement for the Meeting (receipt of which is hereby acknowledged).

     THIS  PROXY WHEN  PROPERLY  EXECUTED  WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1 AND 2.

                    (continued and to be signed on reverse side)



<PAGE>


                         Please date, sign and mail your
                      proxy card back as soon as possible!

                         Annual Meeting of Stockholders
                         COLLAGEX PHARACEUTICALS, INC.

                                  COMMON STOCK

                                  May 8, 2000




                Please Detatch and mail in the Envelope Provided

- --------------------------------------------------------------------------------
A [X]Please mark your votes as in this example.

1.   ELECTION OF             FOR         WITHHELD   Nominees:
     DIRECTORS.              [  ]          [   ]    Brian M. Gallagher, Ph.D.
     VOTE FOR all the nominees listed at right;     Helmer P.K. Agersborg, Ph.D.
     except vote withheld from the following        Peter R. Barnett, D.M.D.
     nominee(s) (if any).                           Robert C. Black
                                                    James E. Daverman
                                                    Robert J. Easton
                                                    Terrence E. Winters. Ph.D.
     ------------------------------

2.   APPROVAL  OF  PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF  KPMG  LLP AS THE
     INDEPENDENT AUDITORS OF THE COMPANY FOR THE YEAR ENDING DECEMBER 31, 2000

          FOR                 AGAINST                  ABSTAIN
        [     ]              [       ]                 [      ]

3.   In his or her  discretion,  the proxy is  authorized  to vote  upon  other
     matters as may properly come before the Meeting.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY,  USING THE ENCLOSED
ENVELOPE.



                              I will              I will not
                              [    ]              [        ]
                                   attend the Meeting.

Signature of Common Stockholder
                               -----------------------------
Signature of Common Stockholder
                               -----------------------------
Dated:
      -------------------

NOTE: THIS PROXY MUST BE SIGNED EXACTLY AS THE NAME APPEARS HEREON.  WHEN SHARES
      ARE  HELD  BY  JOINT  TENANTS,  BOTH  SHOULD  SIGN.  IF  THE  SIGNER  IS A
      CORPORATION,  PLEASE SIGN FULL CORPORATE NAME BY DULY AUTHORIZED  OFFICER,
      GIVING FULL TITLE AS SUCH. IF THE SIGNER IS A PARTNERSHIP,  PLEASE SIGN IN
      PARTNERSHIP NAME BY AUTHORIZED PERSON.

<PAGE>


                                 PREFERRED STOCK

                        COLLAGENEX PHARMACEUTICALS, INC.

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

      The undersigned hereby constitutes and appoints Brian M. Gallagher,  Ph.D.
and Nancy C.  Broadbent,  and each of them, his or her true and lawful agent and
proxy with full  power of  substitution  in each,  to  represent  and to vote on
behalf of the undersigned all of the shares of CollaGenex Pharmaceuticals,  Inc.
(the "Company")  which the undersigned is entitled to vote at the Annual Meeting
of  Stockholders  of the Company to be held at the Marriott  Hotel,  1201 Market
Street,  Philadelphia,  Pennsylvania at 8:30 A.M., local time, on Monday, May 8,
2000,  and at any  adjournment  or  adjournments  thereof,  upon  the  following
proposals more fully  described in the Notice of Annual Meeting of  Stockholders
and Proxy Statement for the Meeting (receipt of which is hereby acknowledged).

     THIS  PROXY WHEN  PROPERLY  EXECUTED  WILL BE VOTED IN THE MANNER  DIRECTED
HEREIN BY THE UNDERSIGNED STOCKHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR PROPOSALS 1 AND 2.

                    (continued and to be signed on reverse side)



<PAGE>


                         Please date, sign and mail your
                      proxy card back as soon as possible!

                         Annual Meeting of Stockholders
                         COLLAGEX PHARACEUTICALS, INC.

                                 PREFERRED STOCK

                                  May 8, 2000




                Please Detatch and mail in the Envelope Provided

- --------------------------------------------------------------------------------
A [X]Please mark your votes as in this example.

1.   ELECTION OF                        FOR         WITHHELD
     STEPHEN A. KAPLAN AS DIRECTOR.     [  ]          [   ]


2.   APPROVAL  OF  PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF  KPMG  LLP AS THE
     INDEPENDENT AUDITORS OF THE COMPANY FOR THE YEAR ENDING DECEMBER 31, 2000

          FOR                 AGAINST                  ABSTAIN
        [     ]              [       ]                 [      ]

3.   In his or her  discretion,  the proxy is  authorized  to vote  upon  other
     matters as may properly come before the Meeting.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY,  USING THE ENCLOSED
ENVELOPE.



                              I will              I will not
                              [    ]              [        ]
                                   attend the Meeting.


Signature of Preferred Stockholder
                                  -----------------------------
Signature of Preferred Stockholder
                                  -----------------------------
Dated:
      -------------------

NOTE: THIS PROXY MUST BE SIGNED EXACTLY AS THE NAME APPEARS HEREON.  WHEN SHARES
      ARE  HELD  BY  JOINT  TENANTS,  BOTH  SHOULD  SIGN.  IF  THE  SIGNER  IS A
      CORPORATION,  PLEASE SIGN FULL CORPORATE NAME BY DULY AUTHORIZED  OFFICER,
      GIVING FULL TITLE AS SUCH. IF THE SIGNER IS A PARTNERSHIP,  PLEASE SIGN IN
      PARTNERSHIP NAME BY AUTHORIZED PERSON.




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