COLLAGENEX PHARMACEUTICALS INC
S-3, EX-5, 2001-01-16
PHARMACEUTICAL PREPARATIONS
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                                                                      EXHIBIT 5

                                HALE AND DORR LLP
                               Counsellors At Law
                               214 Carnegie Center
                           Princeton, New Jersey 08540

                                January 16, 2001

CollaGenex Pharmaceuticals, Inc.
41 University Drive
Newtown, Pennsylvania 18940

Gentlemen:

     This  opinion  is  furnished  to you  in  connection  with  a  Registration
Statement  on Form  S-3 (the  "Registration  Statement")  to be  filed  with the
Securities and Exchange  Commission (the "Commission")  under the Securities Act
of 1933, as amended (the "Securities Act"), for the registration of an aggregate
of 259,462 shares of the common stock,  $.01 par value per share (the "Shares"),
of CollaGenex Pharmaceuticals, Inc., a Delaware corporation (the "Company"). All
of the Shares are being  registered  on behalf of  certain  stockholders  of the
Company (the "Selling Stockholders").

     We  have  acted  as  counsel  for  the  Company  in  connection   with  the
registration  for resale of the Shares.  We have  examined  signed copies of the
Registration  Statement to be filed with the  Commission.  We have also examined
and relied upon the minutes of  meetings  of the  stockholders  and the Board of
Directors of the Company as provided to us by the Company, stock record books of
the Company as provided to us by the Company,  the Certificate of  Incorporation
and By-Laws of the Company,  each as restated  and/or  amended to date, and such
other  documents  as we have deemed  necessary  for  purposes of  rendering  the
opinions hereinafter set forth.

     In  our  examination  of the  foregoing  documents,  we  have  assumed  the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to
us as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

     We assume that the appropriate action will be taken, prior to the offer and
sale of the  Shares,  to  register  and  qualify  the  Shares for sale under all
applicable state securities or "blue sky" laws.

     We express no  opinion  herein as to the laws of any state or  jurisdiction
other than the Delaware General Corporation Law.

     Based upon and subject to the  foregoing,  we are of the  opinion  that the
Shares have been duly  authorized  and, when issued in accordance with the terms
of the Company's  Certificate of  Incorporation,  will be validly issued,  fully
paid and nonassessable.


<PAGE>


CollaGenex Pharmaceuticals, Inc.
January 16, 2001
Page -2-


     It is understood  that this opinion is to be used only in  connection  with
the offer and sale of the Shares while the Registration Statement is in effect.

     Please note that we are opining only as to the matters  expressly set forth
herein, and no opinion should be inferred as to any other matters.

     We hereby  consent to the filing of this opinion with the  Commission as an
exhibit to the  Registration  Statement in accordance  with the  requirements of
Item  601(b)(5) of Regulation S-K under the Securities Act and to the use of our
name therein and in the related prospectus under the caption "Legal Matters." In
giving  such  consent,  we do not hereby  admit that we are in the  category  of
persons whose consent is required  under Section 7 of the  Securities Act or the
rules and regulations of the Commission.

                                       Very truly yours,


                                       /s/  Hale and Dorr LLP


                                       HALE AND DORR LLP





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