ARADIGM CORP
S-8, 1996-11-12
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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As filed with the Securities and Exchange Commission on
November  12, 1996       Registration No. 333-_____


                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM S-8
                            REGISTRATION STATEMENT
                                    UNDER
                          THE SECURITIES ACT OF 1933


                             Aradigm Corporation
            (Exact name of registrant as specified in its charter)

           California                    94-3133088
(State  of  Incorporation)  (I.R.S.  Employer  Identification No.)


                           26219 Eden Landing Road
                          Hayward, California 94545
                                (510) 783-3100
        (Address and telephone number of principal executive offices)



                                
                   1996 Equity Incentive Plan
                  Employee Stock Purchase Plan
         1996 Non-Employee Directors' Stock Option Plan
                                
                       Richard P. Thompson
              President and Chief Executive Officer
                       Aradigm Corporation
                     26219 Eden Landing Road
                    Hayward, California 94545
                         (510) 783-0100
    (Name, address, including zip code, and telephone number,
           including area code, of agent for service)
                                
                           Copies to:
                     Jeffrey S. Zimman, Esq.
                      Jamie E. Chung, Esq.
                       Cooley Godward llp
                 One Maritime Plaza, 20th Floor
                    San Francisco, CA  94111
                         (415) 693-2000
                                
                                
                 CALCULATION OF REGISTRATION FEE
                                
   Title of     Amount to be     Proposed       Proposed       Amount of
  Securities     Registered       Maximum        Maximum      Registration
    to be                        Offering       Aggregate         Fee
  Registered                     Price Per      Offering
                                 Share(1)       Price(1)

Stock Options     1,341,490       $5.00 -    $12,057,788.50   $3,653.51
and Common                       $10.0625
Stock (no par
value)

(1)  Estimated  solely for the purpose of calculating the  amount
     of  the registration fee.  The offering price per share  and
     aggregate  offering price are based upon  (a)  the  weighted
     average  exercise  price,  for  shares  subject  to  options
     previously  granted under the Aradigm Corporation ("Company"
     or  "Registrant")  1996  Equity Incentive  Plan  (the  "1996
     Plan") (pursuant to Rule 457(h) under the Securities Act  of
     1933,  as  amended (the "Act")) (b) the average of the  high
     and low prices of the Company's Common Stock as reported  on
     the  Nasdaq  National Market on November  8,  1996  for  (i)
     shares available for grant pursuant to the 1996 Non-Employee
     Directors'  Stock  Option Plan, (ii)  shares  available  for
     grant  pursuant to the 1996 Plan and (iii) shares  available
     for  grant  pursuant  to the Employee  Stock  Purchase  Plan
     (pursuant  to  Rule  457(c) under the Act).   The  following
     chart shows the calculation of the registration fee:


     Type of Shares        Number of  Offering     Aggregate
                           Shares     Price        Offering Price
                                      Per Share
Shares issuable pursuant    284,633  $5.00(1)(a)   $1,423,165.00
to outstanding options
under the 1996 Equity
Incentive Plan

Shares issuable pursuant    681,857      (1)(b)    $6,861,186.00
to the 1996 Equity
Incentive Plan

Shares issuable pursuant    225,000      (1)(b)    $2,264,062.50
to the 1996 Non-Employee
Directors' Stock Option
Plan

Shares issuable pursuant    150,000      (1)(b)    $1,509,375.00
to the Employee Stock
Purchase Plan

Proposed Maximum                                  $12,057,788.50
Aggregate Offering Price                                          
                                                       x .000303

Registration Fee                                       $3,653.51

______________

   Approximate  date  of  commencement of proposed  sale  to  the
public:  As soon as practicable after this Registration Statement
becomes effective.


                            PART II


Item 3.  Incorporation Of Certain Documents By Reference

    The  following  documents  filed  by  the  Company  with  the
Securities and Exchange Commission are incorporated by  reference
into this Registration Statement:

     (a)    The Company's latest annual report on Form 10-K filed
pursuant  to  Sections 13(a) or 15(d) of the Securities  Exchange
Act  of 1934, as amended (the "Exchange Act"), or either (1)  the
Company's  latest prospectus filed pursuant to Rule 424(b)  under
the Securities Act of 1933, as amended (the "Act"), that contains
audited financial statements for the Company's latest fiscal year
for  which  such statements have been filed, or (2) the Company's
effective  registration statement on Form 10 or 20-F filed  under
the  Exchange Act containing audited financial statements for the
Company's latest fiscal year.

(b)     All  other  reports filed pursuant to Sections  13(a)  or
15(d)  of  the  Exchange Act since the end  of  the  fiscal  year
covered by the annual reports, the prospectus or the registration
statement referred to in (a) above.
(c)     The  description of the Company's Common Stock  which  is
contained  in  a registration statement filed under the  Exchange
Act,  including any amendment or report filed for the purpose  of
updating such description.
   All  reports  and other documents subsequently  filed  by  the
Company  pursuant to Sections 13(a), 13(c), 14 and 15(d)  of  the
Exchange  Act  prior to the filing of a post-effective  amendment
which  indicates that all securities offered have  been  sold  or
which deregisters all securities then remaining unsold, shall  be
deemed to be incorporated by reference herein and to be a part of
this  registration statement from the date of the filing of  such
reports and documents.

Item 6.  Indemnification Of Directors And Officers

   The  Company's Amended and Restated Articles of  Incorporation
and  Bylaws  include  provisions to (i)  eliminate  the  personal
liability  of  its directors for monetary damages resulting  from
breaches  of  their  fiduciary duty to the  extent  permitted  by
California  law  and  (ii) permit the Company  to  indemnify  its
directors and officers, employees and other agents to the fullest
extent  permitted  by  the  California  Corporations  Code   (the
"Corporations   Code").   Pursuant  to   Section   317   of   the
Corporations  Code,  a corporation generally  has  the  power  to
indemnify  its present and former directors, officers,  employees
and  agents  against any expenses incurred by them in  connection
with any suit to which they are, or are threatened to be made,  a
party  by  reason of their serving in such positions so  long  as
they acted in good faith and in a manner they reasonably believed
to be in, or not opposed to, the best interests of a corporation,
and  with  respect to any criminal action, they had no reasonable
cause  to  believe  their  conduct  was  unlawful.   The  Company
believes  that  these  provisions are necessary  to  attract  and
retain  qualified  persons  as  directors  and  officers.   These
provisions  do  not  eliminate  liability  for  breach   of   the
director's  duty  of loyalty to the Company or its  shareholders,
for  acts or omissions not in good faith or involving intentional
misconduct or knowing violations of law, for any transaction from
which  the director derived an improper personal benefit  or  for
any willful or negligent payment of any unlawful dividend.

   The Company has entered into agreements with its directors and
executive  officers that require the Company  to  indemnify  such
persons against expenses, judgments, fines, settlements and other
amounts  that  such  person  becomes  legally  obligated  to  pay
(including  expenses of a derivative action) in  connection  with
any  proceeding, whether actual or threatened, to which any  such
person may be made a party by reason of the fact that such person
is  or  was  a director or officer of the Company or any  of  its
affiliated enterprises, provided such person acted in good  faith
and  in a manner such person reasonably believed to be in or  not
opposed   to   the   best   interests  of   the   Company.    The
indemnification agreements also set forth certain procedures that
will   apply   in  the  event  of  a  claim  for  indemnification
thereunder.

                            EXHIBITS

Exhibit
Number

5.1         Opinion of Cooley Godward llp.
24.1        Consent of Ernst & Young llp, independent auditors.
24.2         Consent  of  Bregante  +  Company  llp,  independent
          auditors
24.3        Consent of Cooley Godward llp.  Reference is made to
                 Exhibit 5.1.
25.1          Power  of  Attorney.   Reference  is  made  to  the
          signature pages.
99.1*       Registrant's 1996 Equity Incentive Plan (the "1996
            Plan").
99.2*       Form of Incentive Stock Option under the 1996 Plan.
99.3*       Form of Non-Statutory Stock Option under the 1996
            Plan.
99.4*       Registrant's Employee Stock Purchase Plan.
99.5*       Registrant's 1996 Non-Employee Directors' Stock
            Option Plan (the "Directors' Plan").
99.6*       Form of Non-Statutory Stock Option under the
            Directors' Plan.


*    Documents  incorporated by reference from  the  Registrant's
     Form S-1 Registration Statement (File No. 333-4236) filed on
     April 30, 1996.



Item 9.  Undertakings

(d)    The undersigned registrant hereby undertakes:

  a.      To file, during any period in which offers or sales are
being  made,  a  post-effective amendment  to  this  registration
statement:

          i.     To include any prospectus required by section 10(a)(3) of
the Securities Act;

               ii.       To reflect in the prospectus any facts or events
          arising after the effective date of the registration statement
          (or the most recent post-effective amendment thereof) which,
          individually or in the aggregate, represent a fundamental change
          in the information set forth in the registration statement.
          Notwithstanding the foregoing, any increase or decrease in volume
          of securities offered (if the total dollar value of securities
          offered would not exceed that which was registered) and any
          deviation from the low or high end of the estimated maximum
          offering range may be reflected in the form of prospectus filed
          with the Commission pursuant to Rule 424(b) ( 230.424(b) of this
          chapter) if, in the aggregate, the changes in volume and price
          represent no more than a 20% change in the maximum aggregate
          offering price set forth in the "Calculation of Registration Fee"
          table in the effective registration statement.

               iii.      To include any material information with respect to the
          plan of distribution not previously disclosed in the registration
          statement or any material change to such information in the
          registration statement;

   Provided, however, that paragraphs (A)(1)(a) and (A)(1)(b)  do
not  apply  if  the  registration statement is  on  Form  S-3  or
Form  S-8 and the information required to be included in a  post-
effective amendment by those paragraphs is contained in  periodic
reports   filed  by  the  issuer  pursuant  to  section   13   or
section  15(d)  of  the  Exchange Act that  are  incorporated  by
reference in the registration statement.

  b.     That, for the purpose of determining any liability under
the  Securities  Act of 1933, each such post-effective  amendment
shall  be  deemed to be a new registration statement relating  to
the   securities  offered  therein,  and  the  offering  of  such
securities  at that time shall be deemed to be the  initial  bona
fide offering thereof.

  c.     To remove from registration by means of a post-effective
amendment  any  of the securities being registered  which  remain
unsold at the termination of the offering.

     (e)    The undersigned registrant hereby undertakes that, for
purposes of determining any liability under the Securities Act of
1933,  each filing of the registrant's annual report pursuant  to
Section  13(a) or Section 15(d) of the Exchange Act  (and,  where
applicable,  each  filing of an employee  benefit  plan's  annual
report  pursuant to section 15(d) of the Exchange  Act  of  1934)
that  is  incorporated by reference in the registration statement
shall  be  deemed to be a new registration statement relating  to
the   securities  offered  therein,  and  the  offering  of  such
securities  at that time shall be deemed to be the  initial  bona
fide offering thereof.

     (f)    Insofar as indemnification for liabilities arising under
the  Securities  Act  of  1933  may be  permitted  to  directors,
officers  and controlling persons of the registrant  pursuant  to
the  foregoing provisions, or otherwise, the registrant has  been
advised  that  in  the  opinion of the  Securities  and  Exchange
Commission  such  indemnification is  against  public  policy  as
expressed in the Securities Act and is, therefore, unenforceable.
In  the  event  that  a  claim for indemnification  against  such
liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person  of
the  registrant in the successful defense of any action, suit  or
proceeding)  is asserted by such director, officer or controlling
person  in  connection with the securities being registered,  the
registrant will, unless in the opinion of its counsel the  matter
has  been settled by controlling precedent, submit to a court  of
appropriate    jurisdiction    the    question    whether    such
indemnification  by it is against public policy as  expressed  in
the Securities Act and will be governed by the final adjudication
of such issue.

                           SIGNATURES

      The  Registrant.   Pursuant  to  the  requirements  of  the
Securities Act of 1933, as amended, the Registrant certifies that
it  has  reasonable grounds to believe that it meets all  of  the
requirements  for  filing on Form S-8 and has  duly  caused  this
Registration  Statement  to  be  signed  on  its  behalf  by  the
undersigned, thereunto duly authorized, in the City  of  Hayward,
State of California, on November 8, 1996.


                                  ARADIGM CORPORATION
                                  By:/s/ Richard P. Thompson
                                  Richard P. Thompson
                                  President and Chief
                                  Executive Officer
                                  (Principal Executive
                                  Officer)

                       POWER OF ATTORNEY

      KNOW  ALL PERSONS BY THESE PRESENTS, that each person whose
signature  appears  below  constitutes and  appoints  Richard  P.
Thompson  and Reid M. Rubsamen, and each or any one of them,  his
true  and  lawful attorney-in-fact and agent, with full power  of
substitution and resubstitution, for him and in his  name,  place
and  stead,  in  any  and all capacities, to  sign  any  and  all
amendments   (including  post-effective   amendments)   to   this
Registration  Statement, and to file the same, with all  exhibits
thereto,  and other documents in connection therewith,  with  the
Securities and Exchange Commission, granting unto said attorneys-
in-fact and agents, and each of them, full power and authority to
do  and  perform  each  and  every act and  thing  requisite  and
necessary  to  be done in connection therewith, as fully  to  all
intents  and  purposes as he might or could do in person,  hereby
ratifying  and  confirming  all that said  attorneys-in-fact  and
agents,  or  any  of  them,  or  their  or  his  substitutes   or
substitute, may lawfully do or cause to be done by virtue hereof.

      Pursuant to the requirements of the Securities Act of 1933,
this  Registration  Statement  has  been  signed  below  by   the
following persons in the capacities and on the dates indicated.
                                                               
          Signature                 Title                    Date
                                                               
  /s/ Richard P. Thompson        President, Chief           November 8,
  Richard P. Thompson            Executive Officer and         1996
                                 Director (Principal
                                 Executive Officer and
                                 Principal Financial
                                 Officer)
                                                               
  /s/ Reid M. Rubsamen, M.D.     Vice President,            November 8,
  Reid M. Rubsamen, M.D.         Medical Affairs,              1996
                                 Secretary and Director
                                                               
  /s/ Lester John Lloyd          Chairman of the Board      November 8,
  Lester John Lloyd              of Directors                  1996
                                                               
  /s/ Burton J. McMurtry, Ph.D.  Director                   November 8,
  Burton J. McMurtry, Ph.D.                                    1996
                                                               
  /s/ Gordon Russell             Director                   November 8,
  Gordon Russell                                               1996
                                                               
  /s/ Jared A. Anderson, Ph.D.    Director                   November 8,
  Jared A. Anderson, Ph.D.                                     1996
                                                               
  /s/ Ross A. Jaffe, M.D.         Director                   November 8,
  Ross A. Jaffe, M.D.                                          1996
                                                               
  /s/ Virgil Thompson             Director                   November 8,
  Virgil Thompson                                              1996
                                                               
  /s/ Fred Silverstein, M.D.      Director                   November 8,
  Fred Silverstein, M.D.                                       1996


                         EXHIBIT INDEX


                                              
 Exhibit   Description                
 Number
 
 5.1       Opinion of Cooley Godward llp.                   
 24.1      Consent of Ernst & Young llp,                    
           independent auditors.
 24.2      Consent of Bregante + Company llp,               
           independent auditors.
 24.3      Consent of Cooley Godward llp.                   
           Reference is made to Exhibit 5.1.
 25.1      Power of Attorney.  Reference is made            
           to the signature pages.
 99.1*     Registrant's 1996 Equity Incentive               
           Plan (the "1996 Plan").
 99.2*     Form of Incentive Stock Option under             
           the 1996 Plan.
 99.3*     Form of Non-Statutory Stock Option               
           under the 1996 Plan.
 99.4*     Registrant's Employee Stock Purchase             
           Plan.
 99.5*     Registrant's 1996 Non-Employee                   
           Directors' Stock Option Plan (the
           "Directors' Plan").
 99.6*     Form of Non-Statutory Stock Option               
           under the Directors' Plan.


*    Documents  incorporated by reference from  the  Registrant's
     Form S-1 Registration Statement (File No. 333-4236) filed on
     April 30, 1996.


 Exhibit 5.1  OPINION OF COOLEY GODWARD LLP



November 8, 1996


Aradigm Corporation
26219 Eden Landing Road
Hayward, CA  94545

Ladies and Gentlemen:

You have requested our opinion with respect to certain matters in
connection with the filing by Aradigm Corporation (the "Company")
of  a  Registration  Statement  on Form  S-8  (the  "Registration
Statement") with the Securities and Exchange Commission  covering
the  offering  of up to 1,341,490 shares of the Company's  Common
Stock,  no  par value, (the "Shares") pursuant to its  1996  Non-
Employee  Directors'  Plan,   1996  Equity  Incentive  Plan   and
Employee Stock Purchase Plan (collectively, the "Plans").

In   connection   with  this  opinion,  we  have   examined   the
Registration  Statement and related Prospectus, the  Plans,  your
Articles of Incorporation and Bylaws, as amended, and such  other
documents, records, certificates, memoranda and other instruments
as  we  deem  necessary  as a basis for this  opinion.   We  have
assumed   the  genuineness  and  authenticity  of  all  documents
submitted to us as originals, the conformity to originals of  all
documents  submitted  to  us  as  copies  thereof,  and  the  due
execution  and delivery of all documents where due execution  and
delivery are a prerequisite to the effectiveness thereof.

On the basis of the foregoing, and in reliance thereon, we are of
the  opinion  that  the  Shares, when  issued  and  paid  for  in
accordance with the Plans, the Registration Statement and Related
Prospectus  will be validly issued, fully paid, and nonassessable
(except  as to shares issued pursuant to certain deferred payment
arrangements,  which  will be fully paid and  nonassessable  when
such deferred payments are made in full).

We  consent  to the filing of this opinion as an exhibit  to  the
Registration Statement.

Very truly yours,

COOLEY GODWARD LLP


By:   /s/ Jeffrey S. Zimman
     Jeffrey S. Zimman



Exhibit 24.1   CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We  consent to the incorporation by reference in the Registration
Statement  (Form  S-8)  pertaining to the 1996  Equity  Incentive
Plan,  the Employee Stock Purchase Plan and the 1996 Non-Employee
Directors'  Stock Option Plan, of our report, dated February  23,
1996,  except Note 8 as to which the date is June 11, 1996,  with
respect  to  the  financial  statements  of  Aradigm  Corporation
included  in its Registration Statement and Prospectus (Form  S-1
No. 333-4236) filed with the Securities and Exchange Commission.


Palo Alto, California
November 8, 1996




Exhibit 24.2   CONSENT OF BREGANTE + COMPANY LLP, INDEPENDENT AUDITORS

We  consent to the incorporation by reference in the Registration
Statement  (Form  S-8)  pertaining to the 1996  Equity  Incentive
Plan,  the Employee Stock Purchase Plan and the 1996 Non-Employee
Directors'  Stock Option Plan, of our report, dated February  22,
1994,  with  respect  to  the  financial  statements  of  Aradigm
Corporation included in its Registration Statement and Prospectus
(Form  S-1  No. 333-4236) filed with the Securities and  Exchange
Commission.


San Francisco, California
November 8, 1996



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