ARADIGM CORP
DEF 14A, 1997-04-14
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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                            SCHEDULE 14A INFORMATION
                PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                         SECURITIES EXCHANGE ACT OF 1934
                         (Amendment No. ______________)


Filed by the Registrant    [X] 
Filed by a party other than the Registrant   [ ]

Check the appropriate box:
[ ]  Preliminary proxy statement
[ ]  Confidential, for use of the Commission only (as permitted by
     Rule 14a-6(e)(2))
[X]  Definitive proxy statement
[ ]  Definitive additional materials
[ ]  Soliciting material pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                               Aradigm Corporation
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


1.  Title of each class of securities to which transactions applies:

    ----------------------------------------------------------------------------

2.  Aggregate number of securities to which transactions applies:

    ----------------------------------------------------------------------------

3.  Per unit price or other underlying value of transaction computed pursuant to
    Exchange  Act Rule  0-11 set forth the  amount  on which the  filing  fee is


    calculated and state how it was determined):

    ----------------------------------------------------------------------------

4.  Proposed maximum aggregate value of transaction:

    ----------------------------------------------------------------------------

5.  Total fee paid:

    ----------------------------------------------------------------------------

[ ]  Fee paid previously with preliminary materials.

[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
    0-11(a)(2)  and  identify the filing for which the  offsetting  fee was paid
    previously.  Identify the previous filing by registration  statement number,
    or the Form or Schedule and the date of its filing.

1.  Amount previously paid:

    ----------------------------------------------------------------------------

2.  Form, Schedule or Registration Statement No.:

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3.  Filing party:

    ----------------------------------------------------------------------------

4.  Date filed:

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<PAGE>


                               ARADIGM CORPORATION
                             26219 Eden Landing Road
                            Hayward, California 94545

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                           TO BE HELD ON MAY 20, 1997

TO THE SHAREHOLDERS OF ARADIGM CORPORATION:

   NOTICE IS HEREBY  GIVEN that the Annual  Meeting of  Shareholders  of Aradigm
Corporation, a California corporation (the "Company"),  will be held on Tuesday,
May 20, 1997 at 9:00 a.m.  local time at the  Holiday  Inn at 1221 Chess  Drive,
Foster City, California for the following purposes:

   1. To  elect  directors  to  serve  for the  ensuing  year  and  until  their
      successors are elected.

   2. To ratify the  selection of Ernst & Young LLP as  independent  auditors of
      the Company for its fiscal year ending December 31, 1997.

   3. To transact such other business as may properly come before the meeting or
      any adjournment or postponement thereof.

   The  foregoing  items of  business  are more  fully  described  in the  Proxy
Statement accompanying this Notice.

   The Board of Directors has fixed the close of business on April 4, 1997,
as the record date for the determination of shareholders entitled to notice
of and to vote at this Annual Meeting and at any adjournment or postponement
thereof.

                                        By Order of the Board of Directors

                                        Reid M. Rubsamen
                                        Secretary

Hayward, California
April 15, 1997

  ALL  SHAREHOLDERS  ARE  CORDIALLY  INVITED  TO ATTEND  THE  MEETING IN PERSON.
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND
RETURN THE  ENCLOSED  PROXY AS  PROMPTLY  AS  POSSIBLE  IN ORDER TO ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN  ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED  STATES) IS  ENCLOSED  FOR THAT  PURPOSE.  EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE  AND YOU WISH TO VOTE AT THE  MEETING,  YOU MUST  OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.


<PAGE>

                               ARADIGM CORPORATION
                             26219 Eden Landing Road
                            Hayward, California 94545

                                 PROXY STATEMENT
                       FOR ANNUAL MEETING OF SHAREHOLDERS

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

   The  enclosed  proxy is  solicited  on behalf of the  Board of  Directors  of
Aradigm Corporation,  a California  corporation (the "Company"),  for use at the
Annual  Meeting of  Shareholders  to be held on May 20, 1997, at 9:00 a.m. local
time (the "Annual Meeting"),  or at any adjournment or postponement thereof, for
the purposes set forth herein and in the accompanying  Notice of Annual Meeting.
The Annual  Meeting will be held at the Holiday Inn at 1221 Chess Drive,  Foster
City,  California.  The  Company  intends  to  mail  this  proxy  statement  and
accompanying proxy card on or about April 15, 1997, to all shareholders entitled
to vote at the Annual Meeting.

SOLICITATION

   The Company will bear the entire cost of solicitation  of proxies,  including
preparation,  assembly,  printing and mailing of this proxy statement, the proxy
and any additional information furnished to shareholders. Copies of solicitation
materials  will  be  furnished  to  banks,  brokerage  houses,  fiduciaries  and
custodians  holding in their names shares of Common Stock  beneficially owned by
others to forward to such beneficial  owners.  The Company may reimburse persons
representing  beneficial  owners of Common  Stock for their costs of  forwarding
solicitation  materials to such  beneficial  owners.  Original  solicitation  of
proxies  by  mail  may  be  supplemented  by  telephone,  telegram  or  personal
solicitation by directors,  officers or other regular  employees of the Company.
No additional compensation will be paid to directors,  officers or other regular
employees for such services.

VOTING RIGHTS AND OUTSTANDING SHARES

   Only  holders of record of Common  Stock at the close of business on April 4,
1997 will be  entitled  to notice of and to vote at the Annual  Meeting.  At the
close of business on April 4, 1997 the Company had  outstanding  and entitled to
vote 10,199,620 shares of Common Stock.

   Each  holder of record of Common  Stock on such date will be  entitled to one
vote for each share held on all  matters to be voted upon.  With  respect to the
election of directors, shareholders may exercise cumulative voting rights. Under
cumulative  voting,  each holder of Common  Stock will be entitled to nine votes
for each share  held.  Each  shareholder  may give one  candidate,  who has been
nominated prior to voting, all the votes such shareholder is entitled to cast or
may  distribute  such votes among as many such  candidates  as such  shareholder
chooses. However, no shareholder will be entitled to cumulative votes unless the
candidate's  name has been placed in nomination prior to the voting and at least
one shareholder has given notice at the meeting,  prior to the voting, of his or
her  intention  to  cumulate  votes.   Unless  the  proxyholders  are  otherwise
instructed,  shareholders,  by means of the accompanying  proxy,  will grant the
proxyholders discretionary authority to cumulative votes.

   All votes will be tabulated by the  inspector of election  appointed  for the
meeting,   who  will  separately   tabulate   affirmative  and  negative  votes,
abstentions and broker non-votes.  Abstentions and broker non- votes are counted
towards a quorum but are not counted for any  purpose in  determining  whether a
matter is approved.

REVOCABILITY OF PROXIES

   Any person  giving a proxy  pursuant  to this  solicitation  has the power to
revoke it at any time  before it is voted.  It may be revoked by filing with the
Secretary of the Company at the Company's principal

<PAGE>

executive office, 26219 Eden Landing Road, Hayward, California, a written notice
of  revocation  or a duly  executed  proxy  bearing a later  date,  or it may be
revoked by attending the meeting and voting in person. Attendance at the meeting
will not, by itself, revoke a proxy.

SHAREHOLDER PROPOSALS

   Proposals of shareholders  that are intended to be presented at the Company's
1998 Annual  Meeting of  Shareholders  must be received by the Company not later
than December 17, 1997 in order to be included in the proxy  statement and proxy
relating to that Annual  Meeting.  Shareholders  are also  advised to review the
Company's Bylaws, which contain additional  requirements with respect to advance
notice of shareholder proposals and director nominations.

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

   There are nine nominees for the nine Board positions presently  authorized in
the  Company's  Bylaws.  Each  director to be elected will hold office until the
next annual meeting of  shareholders  and until his successor is elected and has
qualified, or until such director's earlier death,  resignation or removal. Each
nominee listed below is currently a director of the Company.

   Shares  represented by executed  proxies will be voted, if authority to do so
is not withheld, for the election of the nine nominees named below. In the event
that any nominee should be unavailable for election as a result of an unexpected
occurrence,  such  shares  will be voted  for the  election  of such  substitute
nominee as management may propose. Each person nominated for election has agreed
to serve if elected  and  management  has no reason to believe  that any nominee
will be unable to serve.

   Directors  are  elected  by a  plurality  of the votes  present  in person or
represented by proxy and entitled to vote.

                        THE BOARD OF DIRECTORS RECOMMENDS
                     A VOTE IN FAVOR OF EACH NAMED NOMINEE.

NOMINEES

   The names of the  nominees and certain  information  about them are set forth
below:

                                               PRINCIPAL OCCUPATION/
NAME                        AGE            POSITION HELD WITH THE COMPANY
- -------------------------- ----- -----------------------------------------------
Lester John Lloyd ......... 60     Chairman of the Board of Directors of Aradigm

Richard P. Thompson ....... 45     President  and  Chief  Executive  Officer  of
                                     Aradigm

Reid M. Rubsamen, M.D.  ... 40     Vice President, Medical Affairs and Secretary
                                     of Aradigm

Jared A. Anderson, Ph.D. .. 59     Investment Advisor to  Electronic Investments
                                     Ltd.

Ross A. Jaffe, M.D. ....... 38     General Partner, Brentwood Associates

Burton J. McMurtry, Ph.D. . 61     General Partner, Technology Venture Investors

Gordon W. Russell. ........ 63     General Partner, Sequoia Capital

Fred E. Silverstein, M.D. . 54     Professor at the University of Washington

Virgil D. Thompson ........ 57     President,   Chief   Executive   Officer  and
                                     Director of Cytel Corporation

   LESTER JOHN LLOYD has been a director of the Company  since 1991 and Chairman
of the Board of Directors  since 1992.  Mr.  Lloyd also served as the  Company's
President from 1992 to 1994 and Chief Financial Officer from 1992 to April 1996.
Mr. Lloyd holds a B.S.M.E.  from the  University of  California,  Berkeley.  Mr.
Lloyd is also a director of Molecular Dynamics.

                                        2


<PAGE>

   RICHARD P.  THOMPSON has been a director of the Company and has served as the
Company's  President and Chief Executive  Officer since 1994. From April 1996 to
February 1997, Mr. Thompson  served as the Company's  Chief  Financial  Officer.
From  1991 to 1994,  he was  President  of  LifeScan,  Inc.,  a  medical  device
manufacturing  and  development  subsidiary of Johnson & Johnson.  Mr.  Thompson
holds a B.S. in biological  sciences from the University of California at Irvine
and an M.B.A. from California Lutheran College.

   REID M. RUBSAMEN,  M.D., a founder of the Company, has been a director of the
Company and has served as the Company's  Vice  President of Medical  Affairs and
Secretary since 1991. Dr. Rubsamen is a Board Certified  anesthesiologist having
received his medical  training at Pacific  Medical  Center,  San  Francisco  and
Massachusetts  General  Hospital,  where in 1989 he served as Chief  Resident in
Anesthesia.  He was also a doctoral candidate in the computer science department
at the  Massachusetts  Institute  of  Technology,  leaving  in 1990 to found the
Company.  Dr. Rubsamen holds an A.B. in biochemistry  and computer  science from
the University of California,  Berkeley,  and an M.S. in computer science and an
M.D. from Stanford University.

   JARED A. ANDERSON, PH.D. has been a director of the Company since 1992. Since
the early 1980s,  Dr.  Anderson has managed a small portfolio of high technology
investments and works closely with members of the investment banking and venture
capital industry. Dr. Anderson is also a director of Classifieds 2000, a company
providing classified advertising over the Internet. Dr. Anderson holds a B.S. in
physics from the  University  of Texas at Austin and a Ph.D. in physics from the
University of California, Berkeley.

   ROSS A. JAFFE,  M.D.  has been a director of the  Company  since 1993.  Since
April 1993,  he has been a general  partner of Brentwood  Associates,  a venture
capital  investment firm,  which he joined in August 1990.  During the period of
1988 to 1995, Dr. Jaffe served part-time as a Clinical  Instructor and Attending
Physician in various clinics of the University of California,  San Francisco and
University of California, Irvine. Dr. Jaffe holds an A.B. in Policy Studies from
Dartmouth College, an M.D. from The Johns Hopkins University School of Medicine,
an M.B.A. from Stanford  University and is Board Certified in internal medicine.
He is also a director of several privately-held companies.

   BURTON J.  MCMURTRY,  PH.D.  has been a director of the  Company  since 1992.
Since July 1980, he has been a general partner of various  limited  partnerships
that, in turn,  are general  partners of various  Technology  Venture  Investors
venture capital partnerships. Mr. McMurtry holds a B.A. and a B.S. in electrical
engineering  from  Rice  University  and  an  M.S.  and a  Ph.D.  in  electrical
engineering  from Stanford  University.  He is also a director of Intuit,  Inc.,
Edify Corporation and SpectraLink Corp.

   GORDON W. RUSSELL has been a director of the Company  since 1992. He has been
a general partner of Sequoia Capital, a venture capital investment  partnership,
since 1979.  Mr. Russell holds an A.B. in history from  Dartmouth  College.  Mr.
Russell is Chairman of the Board of Overseers of the  Dartmouth  Medical  School
and is  Chairman  Emeritus  of the Board of  Trustees  of the Palo Alto  Medical
Foundation.  Mr. Russell is also a director of SangStat Medical Corp.,  ChemTrak
Incorporated,  Fusion  Medical  Corp.  and  several  privately-held  health care
companies.

   FRED E. SILVERSTEIN,  M.D. has been a director of the Company since 1996. Dr.
Silverstein is a Clinical Professor of Medicine at the University of Washington,
Seattle.  Since  1994,  he has been a partner  of  Frazier &  Company  L.P.,  an
investment partnership.  He holds a B.S. from Alfred University and an M.D. from
Columbia University College of Physicians and Surgeons. He is Board Certified in
internal medicine and  gastroenterology.  Dr.  Silverstein is also a director of
two medical device  development  companies,  Vision Sciences Inc. and Diametrics
Medical Inc., and several privately-held companies. He holds more than 20 United
States patents on a variety of medical devices.

   VIRGIL D.  THOMPSON  has been a director  of the Company  since  1995.  Since
January  1996,  he has been the  President  and Chief  Executive  Officer  and a
director of Cytel Corporation, a biopharmaceutical company. From 1991 to 1993 he
was  President  of Syntex  Laboratories,  Inc.  a  pharmaceutical  company.  Mr.
Thompson  holds a B.S. in Pharmacy  from Kansas  University  and a J.D. from The
George  Washington  University  Law  School.  He  is  also  a  director  of  two
pharmaceutical   companies,   Biotechnology   General   Corporation  and  Cypros
Pharmaceutical Corporation.

                                        3


<PAGE>

BOARD COMMITTEES AND MEETINGS

   During the fiscal year ended December 31, 1996 the Board of Directors held 11
meetings. The Board has an Audit Committee and a Compensation Committee.

   The Audit  Committee  monitors  the  corporate  financial  reporting  and the
internal and external audits of the Company, provides the Board of Directors the
results  of its  examinations  and  recommendations,  outlines  to the  Board of
Directors the improvements made, or to be made, in internal accounting controls,
and  nominates  independent  auditors.  The Audit  Committee  is composed of two
non-employee  directors:  Burton J. McMurtry,  Ph.D. and Gordon W. Russell.  The
Audit Committee met once during the fiscal year ended December 31, 1996.

   The Compensation  Committee recommends to the Board of Directors compensation
levels  for  officers  of  the  Company,  establishes  compensation  levels  for
non-officer  employees of the  Company,  makes  recommendations  to the Board of
Directors  regarding  stock  option  grants  under  the  Company's  1996  Equity
Incentive Plan (the "Incentive Plan"),  and otherwise  administers the Incentive
Plan. The Compensation  Committee is composed of three  non-employee  directors:
Jared A.  Anderson,  Ph.D.,  Ross A. Jaffe,  M.D.  and Virgil D.  Thompson.  The
Compensation Committee met once during the fiscal year ending December 31, 1996.

   During the fiscal year ended December 31, 1996,  each director  except Virgil
D. Thompson  attended at least 75% of the aggregate of the meetings of the Board
and of the  committees  on which he served,  held during the period for which he
was a director or committee member, respectively.

                                   PROPOSAL 2

                RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

   The  Board of  Directors  has  selected  Ernst & Young  LLP as the  Company's
independent  auditors  for the fiscal  year  ending  December  31,  1997 and has
further  directed that management  submit the selection of independent  auditors
for  ratification by the  shareholders at the Annual Meeting.  Ernst & Young LLP
has audited the Company's  financial  statements since 1995.  Representatives of
Ernst & Young LLP are expected to be present at the Annual Meeting, will have an
opportunity  to make a  statement  if they so desire  and will be  available  to
respond to appropriate questions.

   Shareholder  ratification  of the  selection  of  Ernst  &  Young  LLP as the
Company's  independent  auditors  is not  required  by the  Company's  Bylaws or
otherwise.  However,  the Board is submitting the selection of Ernst & Young LLP
to the shareholders for ratification as a matter of good corporate practice.  If
the shareholders fail to ratify the selection, the Audit Committee and the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Audit Committee and the Board in their  discretion may direct the
appointment  of  different  independent  auditors at any time during the year if
they  determine that such a change would be in the best interests of the Company
and its shareholders.

   The  affirmative  vote of the holders of a majority of the shares  present in
person or represented by proxy and voting at the Annual Meeting will be required
to ratify the selection of Ernst & Young LLP.

   At a meeting  held on March 14,  1995,  the Board of Directors of the Company
approved the engagement of Ernst & Young LLP as its independent auditors for the
fiscal year ended  December 31, 1994.  Prior to the  engagement of Ernst & Young
LLP, Bregante + Company LLP served as independent  auditors of the Company.  The
Audit  Committee  of the Board of  Directors  approved the change in auditors on
that date.

   The report of Bregante + Company LLP on the  Company's  financial  statements
for the year ended  December  31, 1993 did not  contain an adverse  opinion or a
disclaimer of opinion and was not qualified or modified as to uncertainty, audit
scope, or accounting principles.

   In connection  with the audit of the Company's  financial  statements for the
fiscal year ended December 31, 1993, there were no disagreements with Bregante +
Company LLP on any matters of  accounting  principles  or  practices,  financial
statement disclosure, or auditing scope and procedures which, if not resolved to
the satisfaction of Bregante + Company LLP, would have caused Bregante + Company
LLP to make reference to the matter in their report.

                                        4


<PAGE>

                        THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2.

                              SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

   The following table sets forth certain information regarding the ownership of
the  Company's  Common  Stock as of January 31, 1997 by: (i) each  director  and
nominee for director;  (ii) each of the executive  officers named in the Summary
Compensation  Table who was employed by the Company in that  capacity on January
31, 1997; (iii) all executive  officers and directors of the Company as a group;
and (iv) all those  known by the  Company to be  beneficial  owners of more than
five percent of its Common Stock.

                                                        BENEFICIAL OWNERSHIP(1)
                                                       ------------------------
                                                       NUMBER OF   PERCENT OF
              BENEFICIAL OWNER                         SHARES(#)    TOTAL(%)
- --------------------------------------------------------------------------------
Burton J. McMurtry, Ph.D. .............................1,217,010     11.9%
 Technology Venture Investors-4, L.P.
 2480 Sand Hill Road, Suite 101
 Menlo Park, CA 94025(2)

Sprout Group ..........................................1,073,644     10.5
 3000 Sand Hill Road
 Menlo Park, CA 94025(3)
 Building 4, Suite 270

Fred E. Silverstein, M.D. .............................  636,363      6.2
 Frazier & Company
 Two Union Square
 601 Union Street, Suite 2110
 Seattle, WA 98101(4)

Ross A. Jaffe, M.D. ...................................  604,863      5.9
 Brentwood Associates VI, L.P.
 2730 Sand Hill Road, Suite 250
 Menlo Park, CA 94025(5)

Jared A. Anderson, Ph.D. ..............................  430,207      4.2
 Electronic Investments Ltd.
 140 Sunrise Drive
 Woodside, CA 94062(6)

Richard P. Thompson(7) ................................  362,595      3.5

Reid M. Rubsamen, M.D.(8) .............................  338,315      3.3

Gordon W. Russell(9) ..................................  291,133      2.9

Igor Gonda, Ph.D.(10) .................................  171,000      1.7

Max D. Fiore(11) ......................................  116,825      1.1

Lester John Lloyd(12) .................................  104,231      1.0

R. Ray Cummings(13) ...................................   72,557       *

Virgil D. Thompson(14) ................................   12,000       *

All executive officers and directors as 
 a group (13 persons) .................................4,422,099     42.6%

- ----------
 
*  Less than one percent.

(1)  This table is based upon  information  supplied by officers,  directors and
     principal  shareholders and Schedules 13D and 13G filed with the Securities
     and Exchange  Commission  (the "SEC").  Unless  otherwise  indicated in the
     footnotes  to this  table and  subject  to  community  property  laws where
     applicable,  the Company  believes that each of the  shareholders  named in
     this table has sole voting and investment  power with respect to the shares
     indicated  as  beneficially  owned.  Applicable  percentages  are  based on
     10,214,057 shares outstanding on January 31, 1997,  adjusted as required by
     rules promulgated by the SEC.

                                         (Footnotes continued on the next page.)

                                        5


<PAGE>
(Footnotes continued from previous page.)

(2)  Represents  1,217,010 shares held by Technology  Venture  Investors-IV,  as
     nominee for various TVI funds. Mr. McMurtry,  a director of the Company, is
     a general  partner  of TVI  Management-4,  L.P.,  the  General  Partner  of
     Technology  Venture  Investors-IV,  and,  as such,  may be  deemed to share
     voting and  investment  power with  respect to such  shares.  Mr.  McMurtry
     disclaims  beneficial  ownership of such shares except to the extent of his
     pecuniary interest in such shares arising from his interest in the entities
     referred to herein.

(3)  Represents  640,823 shares held by Sprout Capital VII, L.P. ("Sprout VII"),
     374,125  shares held by Sprout  Capital VI, L.P.  ("Sprout  VI") and 58,696
     shares held by DLJ Capital  Corporation  ("DLJCC").  DLJCC is the  Managing
     General  Partner of Sprout VII and Sprout VI and, as such, may be deemed to
     share voting and investment  power with respect to the shares  beneficially
     owned by Sprout VII and  Sprout  VI.  Donaldson,  Lufkin &  Jenrette,  Inc.
     ("DLJ")  directly owns all of the capital stock of DLJCC and, as such,  may
     be deemed to share voting and  investment  power with respect to the shares
     held by DLJCC,  Sprout  VII and  Sprout VI. As of  February  3,  1997,  The
     Equitable Companies Incorporated  ("Equitable") beneficially owns, directly
     and  indirectly,  78.2% of DLJ and, as such,  may be deemed to share voting
     and investment  power with respect to the shares held by DLJCC,  Sprout VII
     and Sprout VI.

(4)  Represents   636,363  shares  held  by  Frazier  Healthcare  II,  L.P.  Dr.
     Silverstein,  a director of the Company, is a member of Frazier Management,
     L.L.C.,  the  Managing  Member of FHM II,  L.L.C.,  the General  Partner of
     Frazier  Healthcare  II, L.P.,  and, as such, may be deemed to share voting
     and investment power with respect to such shares. Dr. Silverstein disclaims
     beneficial  ownership of such shares  except to the extent of his pecuniary
     interest in such shares arising from his interest in Frazier Healthcare II,
     L.P.

(5)  Represents 604,863 shares held by Brentwood  Associates VI, L.P. Dr. Jaffe,
     a director of the Company,  is a general  partner of Brentwood VI Ventures,
     L.P., the General  Partner of Brentwood  Associates VI, L.P., and, as such,
     may be deemed to share  voting and  investment  power with  respect to such
     shares. Dr. Jaffe disclaims  beneficial  ownership of such shares except to
     the  extent of his  pecuniary  interest  in such  shares  arising  from his
     interest in the entities referred to herein.

(6)  Represents 430,207 shares held by Electronic Investments Ltd. Dr. Anderson,
     a  director  of  the  Company,   is  the   Attorney-in-Fact  of  Electronic
     Investments  Ltd.,  and,  as  such,  may be  deemed  to  share  voting  and
     investment  power  with  respect to such  shares.  Dr.  Anderson  disclaims
     beneficial  ownership of such shares  except to the extent of his pecuniary
     interest arising from his interest in Electronic Investments Ltd.

(7)  Represents 233,158 shares held by Mr. Thompson,  400 shares held by members
     of Mr.  Thompson's  immediate  family,  74,037  shares held by the Thompson
     Family  Trust and 15,000  shares  held by  Thompson  Family  Partners.  Mr.
     Thompson is a Trustee of the Thompson Family Trust and a General Partner of
     Thompson  Family  Partners and, as such,  may be deemed to share voting and
     investment  power with  respect to the shares held by the  Thompson  Family
     Trust and Thompson  Family  Partners.  Mr.  Thompson  disclaims  beneficial
     ownership of the shares held by his family  members,  the  Thompson  Family
     Trust and Thompson Family Partnership except to the extent of his pecuniary
     and proportionate  partnership  interest arising from his interest therein.
     Includes 40,000 shares subject to an option  exercisable  within 60 days of
     January 31, 1997.

(8)  Includes 20,000 shares subject to an option  exercisable  within 60 days of
     January 31, 1997.

(9)  Represents 678 shares held by Mr.  Russell,  250,478 shares held by Sequoia
     Capital V, 7,120  shares  held by Sequoia  Technology  Partners  V,  13,792
     shares held by Sequoia XXII, 8,332 shares held by Sequoia XXIIII and 10,733
     shares held by Sequoia XXIV. Mr. Russell,  a director of the Company,  is a
     general partner of Sequoia Technology Partners V and Sequoia Partners F.R.,
     the  General  Partner of Sequoia  Capital V, and an  investment  advisor of
     Sequoia XXII,  Sequoia XXIII and Sequoia XXIV,  and, as such, may be deemed
     to share  voting and  investment  power with  respect to such  shares.  Mr.
     Russell  disclaims  beneficial  ownership  of the  shares  held by  Sequoia
     Capital V, Sequoia  Technology  Partners V, Sequoia XXII, Sequoia XXIII and
     Sequoia  XXIV  except to the  extent  of his  pecuniary  and  proportionate
     partnership  interest  in such  shares  arising  from his  interest  in the
     entities referred to herein.

(10) Represents  150,200  shares held by Dr. Gonda.  Also  represents 800 shares
     held by  members of Dr.  Gonda's  immediate  family.  Dr.  Gonda  disclaims
     beneficial  ownership of such shares.  Includes 20,000 shares subject to an
     option exercisable within 60 days of January 31, 1997.

(11) Includes 10,000 shares subject to an option  exercisable  within 60 days of
     January 31, 1997.
                                         (Footnotes continued on the next page.)

                                        6
<PAGE>

(Footnotes continued from previous page.)

(12) Represents  95,611  shares held by Mr.  Lloyd and 8,620  shares held by The
     Lloyd Trust. Mr. Lloyd,  Chairman of the Board of Directors of the Company,
     is Trustee of The Lloyd Trust and, as such,  may be deemed to share  voting
     and  investment  power with  respect to the shares held by The Lloyd Trust.
     Mr. Lloyd disclaims  beneficiary  ownership of the shares held by The Lloyd
     Trust  except to the  extent of his  pecuniary  interest  arising  from his
     interest in such entity.  Mr. Lloyd is an investment advisor of Farm Street
     Investments Ltd. and disclaims  beneficial  ownership of the 293,823 shares
     held by Farm Street Investments Ltd.

(13) Represents  71,857  shares held by Mr.  Cummings and 700 shares held by Mr.
     Cummings's spouse.

(14) Represents 12,000 shares subject to an option exercisable within 60 days of
     January 31, 1997.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

   Section  16(a)  of the  Securities  Exchange  Act of 1934  (the  "1934  Act")
requires the Company's  directors and  executive  officers,  and persons who own
more than ten percent of a registered class of the Company's equity  securities,
to file with the SEC  initial  reports of  ownership  and  reports of changes in
ownership of Common Stock and other equity securities of the Company.  Officers,
directors  and  greater  than  ten  percent  shareholders  are  required  by SEC
regulation  to furnish the Company  with copies of all Section  16(a) forms they
file.

   To the  Company's  knowledge,  based solely on a review of the copies of such
reports  furnished  to the  Company and  written  representations  that no other
reports  were  required,  during the fiscal  year ended  December  31 1996,  all
Section 16(a) filing  requirements  applicable  to its  officers,  directors and
greater than ten percent  beneficial  owners were complied with; except that one
report,  each  covering  one  transaction,  was filed late by each of Richard P.
Thompson, Igor Gonda, Ph.D., R. Ray Cummings, Jared A. Anderson,  Ph.D., Ross A.
Jaffe, M.D., Lester John Lloyd, Burton J. McMurtry, Ph.D. and Technology Venture
Investors-4, L.P.

                             EXECUTIVE COMPENSATION

COMPENSATION OF DIRECTORS

   Directors do not currently receive any cash compensation from the Company for
their service as members of the Board of Directors, although they are reimbursed
for certain expenses incurred in connection with attendance at Board meetings in
accordance with Company policy.

   Each  non-employee  director of the Company also receives stock option grants
under the Non- Employee  Directors' Stock Option Plan (the  "Directors'  Plan").
Only non-employee directors of the Company are eligible to receive options under
the Directors'  Plan.  Options granted under the Directors' Plan are intended by
the Company not to qualify as incentive stock options under the Code.

   Option  grants under the  Directors'  Plan are  non-discretionary.  Under the
Directors'  Plan, each person who is elected for the first time to be a director
of the Company after the  Company's  initial  public  offering and who is not an
employee of the Company is automatically granted,  without further action by the
Company, the Board of Directors or the shareholders of the Company, an option to
purchase 7,500 shares of Common Stock of the Company.  On June 19th of each year
(or the next business day should such date be a legal  holiday)  beginning  with
June 19, 1997,  each member of the  Company's  Board of Directors  who is not an
employee of the Company is also automatically granted under the Directors' Plan,
without  further  action  by  the  Company,   the  Board  of  Directors  or  the
shareholders of the Company,  an option to purchase 7,500 shares of Common Stock
of the  Company  (pro-rated  for  non-employee  directors  with less than a full
year's tenure).

   Options  under  the  Directors'  Plan  will  vest  in four  equal,  quarterly
installments  commencing  on the date of the grant of the option.  The  exercise
price of the options  granted under the Directors' Plan is the fair market value
of the Common Stock  granted on the date of grant.  No option  granted under the
Directors' Plan may be exercised after the expiration of ten years from the date
it was  granted.  Options  granted  under  the  Directors'  Plan  are  generally
non-transferable  except  pursuant to a qualified  domestic  relations  order in
beneficiary  descriptions.  In the event of certain changes of control,  options
outstanding

                                        7


<PAGE>

under the  Directors'  Plan will  automatically  become  fully  vested  and will
terminate if not exercised prior to such change of control.  The Directors' Plan
will  terminate  at the  direction of the Board.  As of December  31,  1996,  no
options to purchase  Common Stock have been granted  pursuant to the  Director's
Plan. 

COMPENSATION OF EXECUTIVE OFFICERS

                             SUMMARY OF COMPENSATION

   The  following  table shows for the fiscal years ended  December 31, 1995 and
1996,  compensation  awarded  or paid to,  or earned  by,  the  Company's  Chief
Executive Officer and its other four most highly compensated  executive officers
(the "Named Executive Officers"):

                           SUMMARY COMPENSATION TABLE

                                                               LONG TERM
                                                              COMPENSATION
                                                                 AWARDS   
                                                ANNUAL      --------------
                                             COMPENSATION     SECURITIES 
                                          -----------------   UNDERLYING
   NAME AND PRINCIPAL POSITION      YEAR  SALARY($) BONUS($) OPTIONS(#)(1)
- --------------------------------- ------ --------- -------- --------------
Richard P. Thompson .............. 1996   185,000   62,221     106,596
 President, Chief Executive        1995   150,000   30,000         --
 Officer and Director                                          
                                                               
Reid M. Rubsamen, M.D. ........... 1996   132,000   35,592      28,065
 Vice President, Medical Affairs,  1995   120,000      --          --
 Secretary and Director                                        
                                                               
Max D. Fiore(4) .................. 1996   130,000   35,074      28,075
 Vice President, Engineering       1995   115,000   15,000         --
                                                               
Igor Gonda, Ph.D.(2) ............. 1996   144,000   39,012         --
 Vice President, Research          1995    33,230      --      150,000
 and Development                   
                                                               
R. Ray Cummings(3) ............... 1996   130,195   35,239       4,357
 Vice President, Business          1995    61,200      --       67,500
 Development                                                 

- ----------

(1)  The Company has not issued any stock appreciation rights (SARs).

(2)  Dr. Gonda joined the Company as Vice  President,  Research & Development in
     September 1995. The amounts for 1995 represent  compensation from such date
     to December 31, 1995.

(3)  Mr. Cummings joined the Company as Vice President,  Business Development in
     April 1995. The amounts for 1995 represent  compensation  from such date to
     December 31, 1995.

                                        8


<PAGE>

                        STOCK OPTION GRANTS AND EXERCISES

   The Company  grants  options to its  executive  officers  under its Incentive
Plan. As of January 31, 1997, options to purchase a total of 313,133 shares were
outstanding  under the  Incentive  Plan and options to purchase  653,357  shares
remained available for grant thereunder.

   The  following  tables  show for the fiscal  year ended  December  31,  1996,
certain information regarding options granted to, exercised by, and held at year
end by, the Named Executive Officers:
<TABLE>

                          OPTION GRANTS IN FISCAL 1996
<CAPTION>

                                             INDIVIDUAL GRANTS
                       ------------------------------------------------------------
                                      PERCENTAGE
                         NUMBER OF     OF TOTAL                                       POTENTIAL REALIZABLE VALUE AT
                         SECURITIES    OPTIONS                                        ASSUMED ANNUAL RATES OF STOCK
                         UNDERLYING   GRANTED TO   EXERCISE    DEEMED                 PRICE APPRECIATION FOR OPTION
                          OPTIONS     EMPLOYEES    OR BASE    VALUE OF                           TERM(5)
                          GRANTED     IN FISCAL     PRICE     DATE OF    EXPIRATION   -----------------------------
          NAME              (#)       1996(%)(3)    ($/SH)  GRANT($)(4)     DATE       0%($)     5%($)      10%($)
- ---------------------- ------------ ------------ ---------- ---------- ------------ --------- ---------- ----------
<S>                     <C>             <C>       <C>         <C>        <C>        <C>       <C>        <C>     
RICHARD P. THOMPSON...  97,500(1)       19.1%     $0.57       $1.57      1/22/06    $97,500   $193,937   $340,889
                         9,096(2)        1.8       0.57        1.57      1/22/06      9,096     18,093     31,802
                                                             
REID M. RUBSAMEN, M.D.  22,500(1)        4.4       0.57        1.57      1/22/06     22,500     44,755     78,667
                         5,565(2)        1.1       0.57        1.57      1/22/06      5,565     11,069     19,457
                                                             
MAX D. FIORE .........  22,500(1)        4.4       0.57        1.57      1/22/06     22,500     44,755     78,667
                         5,575(2)        1.1       0.57        1.57      1/22/06      5,575     11,089     19,492
                                                             
IGOR GONDA, PH.D......     --            --         --          --          --         --         --         --
                                                             
R. RAY CUMMINGS ......   4,357(2)        0.9       0.57        1.57      1/22/06      4,357      8,667     15,233
<FN>                                                         
- ----------                                                   
                                                           
(1)  Option vests quarterly over a four year period.  The option will fully vest
     upon a change of  control,  as defined in the  Incentive  Plan,  unless the
     acquiring company assumes the options or substitutes  similar options.  The
     Board of Directors  may reprice  options  under the terms of the  Incentive
     Plan.

(2)  Option vests on date of grant.  The Board of Directors may reprice  options
     under the terms of the Incentive Plan.

(3)  Based on options to purchase 510,024 shares granted in 1996.

(4)  The deemed value for the date of grant was determined  solely for financial
     accounting purposes.

(5)  The  potential  realizable  value is based on the term of the option at its
     time of grant (10 years). It is calculated by assuming that the stock price
     on the date of grant  appreciates at the indicated annual rate,  compounded
     annually for the entire term of the option and that the option is exercised
     and sold on the last day of its term for the appreciated stock price. These
     amounts represent certain assumed rates of appreciation only, in accordance
     with the rules of the SEC,  and do not  reflect the  Company's  estimate or
     projection of future stock price  performance.  Actual  gains,  if any, are
     dependent on the actual future  performance  of the Company's  Common Stock
     and no gain to the  optionee is possible  unless the stock price  increases
     over the option term, which will benefit all shareholders.
</FN>
</TABLE>

                                        9



<PAGE>

<TABLE>

                 AGGREGATED OPTION EXERCISES IN FISCAL 1996, AND
                     VALUE OF OPTIONS AT END OF FISCAL 1996
<CAPTION>

                                                            NUMBER OF
                                                           SECURITIES       VALUE OF
                                                           UNDERLYING      UNEXERCISED
                                                           UNEXERCISED    IN-THE-MONEY
                                                          OPTIONS/SARS    OPTIONS/SARS
                                                          AT FY-END (#)   AT FY-END ($)
                           SHARES ACQUIRED     VALUE      EXERCISABLE/    EXERCISABLE/
NAME                        ON EXERCISE(#) REALIZED($)(1) UNEXERCISABLE   UNEXERCISABLE
- -------------------------- --------------- ------------ --------------- ---------------
<S>                          <C>             <C>              <C>              <C>
Richard P. Thompson(2)....   106,596         $466,890          --              --

Reid M. Rubsamen, M.D.(3).    28,065          122,924          --              --
 
Max D. Fiore(4)...........   106,825          473,789          --              --

Igor Gonda, Ph.D..........       --               --           --              --

R. Ray Cummings ..........     4,357           19,084          --              --
- ----------
<FN>
(1)  Value  realized is based on the per share  deemed  values of the  Company's
     Common  Stock on the date of exercise,  determined  after the date of grant
     solely for financial accounting purposes,  minus the exercise price without
     taking into  account any taxes that may be payable in  connection  with the
     transaction.

(2)  Options  exercised  pursuant to an Early Exercise Stock Purchase  Agreement
     executed by Mr. Thompson and the Company.  As of December 31, 1996,  79,221
     shares were subject to the Company's right of repurchase.

(3)  Options  exercised  pursuant to an Early Exercise Stock Purchase  Agreement
     executed by Dr. Rubsamen and the Company.  As of December 31, 1996,  18,284
     shares were subject to the Company's right of repurchase.

(4)  Options  exercised  pursuant to an Early Exercise Stock Purchase  Agreement
     executed by Mr.  Fiore and the Company.  As of December  31,  1996,  52,738
     shares were subject to the Company's right of repurchase.
</FN>
</TABLE>

              REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF

                       DIRECTORS ON EXECUTIVE COMPENSATION(1)

   The  Compensation  Committee of the Board of Directors (the  "Committee")  is
composed of three  non-employee  directors.  The  Committee is  responsible  for
setting and  administering  the policies that govern annual executive  salaries,
bonuses  and  stock  option  grants.   The  Committee   annually  evaluates  the
performance,  and determines the level of  compensation,  of the Chief Executive
Officer  ("CEO"),  and the other executive  officers of the Company based upon a
mix of the  achievement  of the  corporate  goals,  individual  performance  and
comparisons with other  biotechnology  companies.  The CEO is not present during
the discussion of his compensation.

   The policies of the Committee with respect to executive  officers,  including
the CEO, are to provide compensation sufficient to attract,  motivate and retain
executives of outstanding  ability and potential and to establish an appropriate
relationship  between  executive  compensation  and the creation of  shareholder
value.  To  meet  these  goals,  the  Committee  has  adopted  a mix  among  the
compensation  elements of salary,  bonus and stock  options,  with a bias toward
stock  options  to  emphasize  the link  between  executive  incentives  and the
creation of shareholder value as measured by the equity markets.

   In general,  the  salaries of  executive  officers are based upon a review of
surveys  of  publicly-held  biotechnology  companies  of a  similar  size to the
Company in terms of number of persons  employed.  Based upon such  surveys,  the
executive  officers'  salaries are set at the  beginning of a fiscal year in the
low-

- ----------
(1)  This Section is not  "soliciting  material," is not deemed "filed" with the
     SEC and is not to be incorporated by reference in any filing of the Company
     under the 1933 Act or the 1934 Act  whether  made  before or after the date
     hereof and irrespective of any general  incorporation  language in any such
     filing.

                                       10


<PAGE>

to mid-range as compared to other  biotechnology  companies described above. The
salaries  are  adjusted at such time  within  such range  based upon  whether an
executive  officer met specific  individual  performance  goals. Such individual
performance  goals are based  upon the  officer's  contribution  toward  Company
goals.  For the fiscal year ended December 31, 1996, the average increase in the
salaries of the executive officers, including the CEO, was 16%.

   Target  bonuses of  executive  officers  are based upon the  surveys of other
biotechnology  companies  described  above and are set at the  beginning of each
fiscal year as a percentage of base salary, which percentage is in the mid-range
as compared to such other  biotechnology  companies.  Actual bonuses are paid at
the end of each  fiscal  year  and may be above or  below  target  depending  on
whether  certain  corporate  goals  have been met  during  the year.  The set of
corporate goals is the same for all executive officers. Because the Company is a
development   stage  company,   the  corporate  goals  are  based  upon  product
development and financing  objectives  rather than the operating  performance of
the Company. The Committee assigns a weight to each goal according to whether it
was attained or surpassed.  The bonus is capped at 150% of the target percentage
based on maximum goal achievement.

   For the fiscal year ended December 31, 1996, the target bonus for the CEO was
set at 30% of base  salary  while  the  target  bonus  for all  other  executive
officers was set at 24% of base salary.  For the bonus for services  rendered in
1996,  the corporate  performance  goals related to: (i) the execution of AERxtm
feasibility  and product  development  agreements,  (ii) the  execution of a key
product  commercialization  agreement with a partner,  (iii) the completion of a
short term feasibility  study  demonstrating the effectiveness of a key product,
(iv)  the  development  of  stand-alone  clinical  supply  capability,  (v)  the
completion of a program demonstrating the feasibility of a new product, (vi) the
completion of a study on the human  bioavailability  of insulin  administered by
AERxtm and (vii) the  completion  of  additional  financing  to fund  additional
development.  Because  most of the  corporate  goals  were  either  attained  or
surpassed  during 1996  according  to  information  obtained by  management  and
approved  by the  Compensation  Committee,  the actual  bonus  awarded  for each
executive officer, including the CEO, was 109% of the target.

   In recommending stock options for executive officers, the Committee considers
individual performance, overall contribution to the Company and the total number
of stock  options to be awarded.  The level of stock option awards is also based
upon the  surveys  of  other  biotechnology  companies  described  above.  After
considering  the criteria  relating to awarding  stock  options,  the  Committee
determined that four executive officers, including the CEO, would receive option
grants in the fiscal year ended December 31, 1996.

   The  Committee  uses  the  same  procedures  described  above  for the  other
executive  officers in setting the annual salary,  bonus and stock option awards
for the CEO,  except  that the CEO's  salary is  adjusted  according  to whether
corporate  rather than  individual  goals are met. The  corporate  goals used in
adjusting the salary of the CEO are the same as the corporate  goals utilized in
adjusting the bonuses of all executive officers.  The CEO's salary and bonus are
determined based on comparisons with other biotechnology  companies and adjusted
according  to  corporate  performance  described  above.  Because  most  of  the
corporate  goals were met in 1996, the CEO received an increase in salary of 23%
and a bonus that was 109% of the target bonus.  In awarding stock  options,  the
Committee considers the CEO's performance,  overall contribution to the Company,
the total  number of options  awarded and the level of options  granted by other
biotechnology  companies  described  above.  Based  on  such  criteria,  the CEO
received  options to purchase an  aggregate of 106,596  shares of the  Company's
Common Stock during the fiscal year ended  December 31, 1996.  Compared to other
biotechnology  companies described above, the CEO's salary and stock options are
in the low- to mid-range.

   Section  162(m) of the Internal  Revenue Code (the "Code") limits the Company
to a  deduction  for federal  income tax  purposes of no more than $1 million of
compensation  paid to certain Named  Executive  Officers  during a taxable year.
Compensation  above $1 million  may be  deducted  if it is  "performance-  based
compensation"  within  the  meaning  of the  Code.  The  Compensation  Committee
believes that at the present time it is unlikely that the  compensation  paid to
any Named Executive  Officer in a taxable year which is subject to the deduction
limit will exceed $1 million. Therefore, the Committee has not yet

                                       11


<PAGE>

established  a policy for  determining  which  forms of  incentive  compensation
awarded  to its  Named  Executive  Officers  shall be  designed  to  qualify  as
"performance-based  compensation." The Committee intends to continue to evaluate
the effects of the statute and any Treasury  regulations and to comply with Code
Section 162(m) in the future to the extent consistent with the best interests of
the Company.

   From the members of the Compensation Committee of Aradigm Corporation:

                                          Jared A. Anderson, Ph.D.
                                          Ross A. Jaffe, M.D.
                                          Virgil D. Thompson

                                       12



<PAGE>

<TABLE>
                      PERFORMANCE MEASUREMENT COMPARISON(1)

   The following graph compares total  stockholder  returns of the Company since
its initial public offering of Common Stock on June 20, 1996 to two indices: the
Nasdaq CRSP Total Return Index for the Nasdaq Stock Market (U.S. companies) (the
"Nasdaq-US") and the Nasdaq Pharmaceutical Index (the  "Nasdaq-Pharmaceutical").
The  total  return  for the  Company's  stock  and for each  index  assumes  the
reinvestment  of dividends,  although  dividends have never been declared on the
Company's stock, and is based on the returns of the component companies weighted
according to their  capitalizations  as of the end of each monthly  period.  The
Nasdaq-US  tracks the aggregate price  performance of equity  securities of U.S.
companies   traded   on   the   Nasdaq   National   Market   (the   "NM").   The
Nasdaq-Pharmaceutical   tracks  the  aggregate   price   performance  of  equity
securities of  pharmaceutical  companies  traded on the NM. The Company's Common
Stock is  traded  on the NM and is a  component  of both the  Nasdaq-US  and the
Nasdaq-Pharmaceutical.

            COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT SINCE
            THE COMPANY'S INITIAL PUBLIC OFFERING ON JUNE 20, 1996(2)


[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]
<CAPTION>

                           6/28/96   7/21/96   8/30/96   9/30/96   10/31/96   11/29/96   12/31/96
                           -------   -------   -------   -------   --------   --------   --------
<S>                         <C>         <C>       <C>      <C>        <C>        <C>        <C>
Nasdaq US                   100         91        96       104        102        109        109
Nasdaq Pharmaceutical       100         89        96       102         98         96         99
Aradigm                     100         82        80        95        102         96         96

<FN>

- ----------

(1)  This Section is not  "soliciting  material," is not deemed "filed" with the
     SEC and is not to be incorporated by reference in any filing of the Company
     under the 1933 Act or the 1934 Act  whether  made  before or after the date
     hereof and irrespective of any general  incorporation  language in any such
     filing.

(2)  Shows the cumulative  total return on investment  assuming an investment of
     $100 in each of the Company, the Nasdaq-US and the Nasdaq-Pharmaceutical on
     June 20, 1996. The cumulative  total return on the Company's stock has been
     computed based on an initial price of $11.00 per share,  the price at which
     the Company's  shares were sold in its initial public  offering on June 20,
     1996.
</FN>
</TABLE>

                                       13



<PAGE>

                              CERTAIN TRANSACTIONS

   In May 1994, the Company  issued and sold to Richard P. Thompson,  President,
Chief Executive Officer,  Chief Financial Officer and a director of the Company,
an  aggregate of 225,000  shares of its Common  Stock for an aggregate  purchase
price of $82,500, payable pursuant to a secured promissory note bearing interest
at the rate of 7% per annum,  with  accrued but unpaid  interest due and payable
annually and the  principal  and  remaining  interest due and payable on July 1,
1999. In January 1996, the Company  granted  options to purchase an aggregate of
106,596 shares of the Company's Common Stock with an exercise price of $0.57 per
share to Mr. Thompson. In February 1996, Mr. Thompson exercised such options for
an  aggregate  exercise  price  of  $60,404,  with  $6,040  paid in cash and the
remaining $54,364 payable pursuant to a secured promissory note bearing interest
at the rate of 5.45% per  annum,  with the  principal  and  accrued  but  unpaid
interest due and payable on February 28, 2001. The largest  aggregate  amount of
Mr. Thompson's  indebtedness to the Company during fiscal 1996 was $142,701. The
outstanding balance of the loans to Mr. Thompson was $142,701 as of December 31,
1996.

   In May 1995, the Company  issued and sold to R. Ray Cummings,  Vice President
of Business  Development  of the Company,  an aggregate of 67,500  shares of its
Common Stock for an aggregate  purchase price of $29,250,  payable pursuant to a
secured  promissory note bearing  interest at the rate of 7.12% per annum,  with
accrued but unpaid  interest  due and payable  annually  and the  principal  and
remaining  interest  due and payable on July 1, 2000.  In May 1995,  the Company
loaned Mr.  Cummings  $53,235  pursuant to a Promissory  Note Secured by Deed of
Trust,  with the  principal and 6% interest due and payable on February 7, 2001.
In January 1996,  the Company  granted an option to purchase 4,357 shares of the
Company's  Common  Stock  with an  exercise  price  of  $0.57  per  share to Mr.
Cummings.  In March 1996,  Mr.  Cummings  exercised  such option for an exercise
price of  $2,469,  with  $247  paid in cash  and the  remaining  $2,222  payable
pursuant to a secured  promissory note bearing interest at the rate of 5.45% per
annum,  with the  principal  and accrued but unpaid  interest due and payable on
March 10, 2001. The largest  aggregate amount of Mr.  Cummings'  indebtedness to
the Company during fiscal 1996 was $91,357. The aggregate outstanding balance of
the loans to Mr. Cummings was $91,357 as of December 31, 1996.

   In September 1995, the Company  granted an option to purchase  150,000 shares
of the Company's  Common Stock with an exercise price of $0.43 per share to Igor
Gonda,  Ph.D.,  Vice President of Research and  Development  of the Company.  In
December 1995, Dr. Gonda  exercised such option for an aggregate  exercise price
of $65,000,  with $6,500 paid in cash and the remaining $58,500 payable pursuant
to a secured  promissory  note bearing  interest at the rate of 5.91% per annum,
with the principal  and accrued but unpaid  interest due and payable on December
27, 2000. In October 1995, the Company  loaned Dr. Gonda $90,000  pursuant to an
interest-free  promissory  note,  with the  principal  amount due and payable in
October 1998. The largest  aggregate  amount of Dr. Gonda's  indebtedness to the
Company during fiscal 1996 was $152,595.  The aggregate  outstanding  balance of
the loans to Dr. Gonda was $152,595 as of December 31, 1996.

   The Company has entered into indemnity  agreements with certain  officers and
directors  which  provide,  among other things,  that the Company will indemnify
such officer or director, under the circumstances and to the extent provided for
therein,  for expenses,  damages,  judgments,  fines and  settlements  he may be
required to pay in actions or proceedings  which he is or may be made a party be
reason of his position as a director, officer or other agent of the Company, and
otherwise to the full extent  permitted  under  California law and the Company's
Bylaws.

   The  Company  believes  that  the  foregoing  transactions  were in its  best
interests.  As a matter  of  policy  these  transactions  were,  and all  future
transactions between the Company and any of its officers, directors or principal
shareholders   will  be,   approved  by  a  majority  of  the   independent  and
disinterested members of the Board of Directors,  and will be in connection with
bona fide business purposes of the Company.

                                       14


<PAGE>

                                  OTHER MATTERS

   The Board of Directors  knows of no other  matters that will be presented for
consideration  at the Annual Meeting.  If any other matters are properly brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote on such matters in accordance  with their best judgment.  


                                        By Order of the Board of Directors


                                        REID M. RUBSAMEN
                                        Secretary

April 15, 1997


   A  COPY  OF THE  COMPANY'S  ANNUAL  REPORT  TO THE  SECURITIES  AND  EXCHANGE
COMMISSION ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 1996 IS AVAILABLE
WITHOUT  CHARGE  UPON  WRITTEN   REQUEST  TO:   CORPORATE   SECRETARY,   ARADIGM
CORPORATION, 26219 EDEN LANDING ROAD, HAYWARD, CA 94545.

                                       15
<PAGE>
                                                                      APPENDIX A

                              Aradigm Corporation
P
R                           26219 Eden Landing Road
O                          Hayward, California 94545
X
Y                     SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF SHAREHOLDERS


     The undersigned hereby appoints Lester John Lloyd,  Richard P. Thompson and
Mark A.  Olbert,  each with the power to  appoint  his  substitute,  and  hereby
authorizes them to represent and to vote, as designated on the reverse side, all
shares of common stock of Aradigm  Corporation (the "Company") held of record by
the  undersigned on April 4th, 1997 at the Annual Meeting of  Shareholders to be
held on May 20th, 1997 and any  adjournments  thereof,  with all powers that the
undersigned  would  possess if  personally  present,  upon and in respect of the
following   matters  in  accordance  with  the  following   instructions,   with
discretionary  authority as to any and all other  matters that may properly come
before the meeting.

     THIS  PROXY  WHEN  PROPERLY  EXECUTED  WILL BE  VOTED  AS  DIRECTED.  IF NO
DIRECTION  IS GIVEN WITH RESPECT TO A  PARTICULAR  PROPOSAL,  THIS PROXY WILL BE
VOTED FOR SUCH PROPOSAL.

     PLEASE  MARK,  DATE,  SIGN AND RETURN THIS PROXY CARD  PROMPTLY,  USING THE
ENCLOSED ENVELOPE. NO POSTAGE IS REQUIRED IF MAILED IN THE UNITED STATES.

                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE
                                                                     -----------
                                                                     SEE REVERSE
                                                                        SIDE
                                                                     -----------
<PAGE>

Dear Fellow Aradigm Shareholder:

Accompanying  this proxy card is Aradigm's 1996 Annual Report and its 1997 Proxy
Statement. As you will see when you read the Annual Report, we achieved a number
of  important  goals in  1996,  and are  working  hard to make  1997 an  equally
important year for your company.

I would  appreciate  your  taking a minute to review the  important  information
enclosed  with this  Proxy.  There are a number of issues  related to  Aradigm's
operation that require your prompt attention.  Your vote counts,  and I strongly
encourage you to exercise your right to vote your shares.

Please  mark the boxes on the proxy card to  indicate  how your  shares  will be
voted,  sign the card,  detach it and return your proxy in the enclosed  postage
paid envelope.

Sincerely,

/s/ Richard P. Thompson
- ------------------------
Richard P. Thompson
President and Chief Executive Officer
Aradigm Corporation

<TABLE>
<CAPTION>
<S>                                                      <C>  

[X] Please mark
    votes as in
    this example.

1. Election of Directors

Elect the      Lester John Lloyd, Jared A. Anderson,
following      Ross A. Jaffe, Burton J. McMurtry,
nominees       Reid M. Rubsamen,                                                                      FOR   AGAINST   ABSTAIN 
whether by     Gordon W. Russell,                        2.  Ratify the appointment of Ernst &       [   ]   [   ]     [   ]  
cumulative     Fred E. Silverstein,                          Young LLP as independent auditors                                
voting or      Richard P. Thompson                           for 1997.                                                        
otherwise:     and Virgil D. Thompson                    

               [  ] FOR      [  ] WITHHELD

[  ] ______________________________________
     For all nominees except as noted above                       MARK HERE
                                                                 FOR ADDRESS  [  ]
                                                                 CHANGE AND
                                                                 NOTE AT LEFT

                                                           Please sign exactly as name appears hereon. Joint owners should 
                                                           each sign. Executors, administrators, trustees, guardians or other 
                                                           fiduciaries should give full title as such. If signing for a corporation,
                                                           please sign in full corporate name by a duly authorized officer.


Signature:_______________________________ Date __________________ Signature ______________________________ Date ___________________

</TABLE>



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