ARADIGM CORP
DEF 14A, 1999-04-15
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
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<PAGE>   1
 
                                  SCHEDULE 14A
                                 (RULE 14A-101)
 
                    INFORMATION REQUIRED IN PROXY STATEMENT
 
                            SCHEDULE 14A INFORMATION
          PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                    EXCHANGE ACT OF 1934 (AMENDMENT NO.   )
 
Filed by the Registrant [x]
 
Filed by a Party other than the Registrant [ ]
 
Check the appropriate box:
 
<TABLE>
<S>                                             <C>
[ ]  Preliminary Proxy Statement                [ ]  Confidential, for Use of the Commission
                                                     Only (as permitted by Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12
</TABLE>
 
                              ARADIGM CORPORATION
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
[X]  No fee required.
 
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.
 
     (1)  Title of each class of securities to which transaction applies:
 
     (2)  Aggregate number of securities to which transaction applies:
 
     (3)  Per unit price or other underlying value of transaction computed
          pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined):
 
     (4)  Proposed maximum aggregate value of transaction:
 
     (5)  Total fee paid:
 
[ ]  Fee paid previously with preliminary materials:
 
[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
 
     (1)  Amount Previously Paid:
 
     (2)  Form, Schedule or Registration Statement No.:
 
     (3)  Filing Party:
 
     (4)  Date Filed:
<PAGE>   2
 
                              ARADIGM CORPORATION
                              3929 POINT EDEN WAY
                           HAYWARD, CALIFORNIA 94545
                            ------------------------
 
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                           TO BE HELD ON MAY 21, 1999
 
TO THE SHAREHOLDERS OF ARADIGM CORPORATION:
 
     NOTICE IS HEREBY GIVEN that the Annual Meeting of Shareholders of Aradigm
Corporation, a California corporation (the "Company"), will be held on Friday,
May 21, 1999 at 9:00 a.m. local time at the Crowne Plaza, 1221 Chess Drive,
Foster City, California for the following purposes:
 
     1. To elect directors to serve for the ensuing year and until their
        successors are elected.
 
     2. To approve the Company's 1996 Equity Incentive Plan, as amended, to
        increase the aggregate number of shares of Common Stock authorized for
        issuance under such plan by 1,820,000.
 
     3. To approve the Company's Employee Stock Purchase Plan, as amended, to
        increase the aggregate number of shares of Common Stock authorized for
        issuance under such plan by 180,000.
 
     4. To ratify the selection of Ernst & Young LLP as independent auditors of
        the Company for its fiscal year ending December 31, 1999.
 
     5. To transact such other business as may properly come before the meeting
        or any adjournment or postponement thereof.
 
     The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.
 
     The Board of Directors has fixed the close of business on April 5, 1999, as
the record date for the determination of shareholders entitled to notice of and
to vote at this Annual Meeting and at any adjournment or postponement thereof.
 
                                          By Order of the Board of Directors
 
                                              /s/ REID M. RUBSAMEN, M.D.
 
                                          --------------------------------------
                                                     Reid M. Rubsamen
                                                        Secretary
 
Hayward, California
April 15, 1999
 
     ALL SHAREHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
REPRESENTATION AT THE MEETING. A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE. EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.
<PAGE>   3
 
                              ARADIGM CORPORATION
                              3939 POINT EDEN WAY
                           HAYWARD, CALIFORNIA 94545
                            ------------------------
 
                                PROXY STATEMENT
                       FOR ANNUAL MEETING OF SHAREHOLDERS
 
                 INFORMATION CONCERNING SOLICITATION AND VOTING
 
GENERAL
 
     The enclosed proxy is solicited on behalf of the Board of Directors of
Aradigm Corporation, a California corporation (the "Company"), for use at the
Annual Meeting of Shareholders to be held on May 21, 1999, at 9:00 a.m. local
time (the "Annual Meeting"), or at any adjournment or postponement thereof, for
the purposes set forth herein and in the accompanying Notice of Annual Meeting.
The Annual Meeting will be held at the Crowne Plaza, 1221 Chess Drive, Foster
City, California. The Company intends to mail this proxy statement and
accompanying proxy card on or about April 15, 1999, to all shareholders entitled
to vote at the Annual Meeting.
 
SOLICITATION
 
     The Company will bear the entire cost of solicitation of proxies, including
preparation, assembly, printing and mailing of this proxy statement, the proxy
and any additional information furnished to shareholders. Copies of solicitation
materials will be furnished to banks, brokerage houses, fiduciaries and
custodians holding in their names shares of Common Stock beneficially owned by
others to forward to such beneficial owners. The Company may reimburse persons
representing beneficial owners of Common Stock for their costs of forwarding
solicitation materials to such beneficial owners. Original solicitation of
proxies by mail may be supplemented by telephone, telegram or personal
solicitation by directors, officers or other regular employees of the Company.
No additional compensation will be paid to directors, officers or other regular
employees for such services.
 
VOTING RIGHTS AND OUTSTANDING SHARES
 
     Only holders of record of Common Stock at the close of business on April 5,
1999 will be entitled to notice of and to vote at the Annual Meeting. At the
close of business on April 5, 1999 the Company had outstanding and entitled to
vote 14,599,922 shares of Common Stock.
 
     Each holder of record of Common Stock on such date will be entitled to one
vote for each share held on all matters to be voted upon at the Annual Meeting.
 
     All votes will be tabulated by the inspector of election appointed for the
meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes. Abstentions and broker non-votes are counted
towards a quorum but are not counted for any purpose in determining whether a
matter is approved.
 
REVOCABILITY OF PROXIES
 
     Any person giving a proxy pursuant to this solicitation has the power to
revoke it at any time before it is voted. It may be revoked by filing with the
Secretary of the Company at the Company's principal executive office, 3929 Point
Eden Way, Hayward, California 94545, a written notice of revocation or a duly
executed proxy bearing a later date, or it may be revoked by attending the
meeting and voting in person. Attendance at the meeting will not, by itself,
revoke a proxy.
<PAGE>   4
 
SHAREHOLDER PROPOSALS
 
     Proposals of shareholders that are intended to be presented at the
Company's 2000 Annual Meeting of Shareholders must be received by the Company
not later than December 16, 1999 in order to be included in the proxy statement
and proxy relating to that Annual Meeting. Shareholders are also advised to
review the Company's Bylaws, which contain additional requirements with respect
to advance notice of shareholder proposals and director nominations."
 
                                   PROPOSAL 1
 
                             ELECTION OF DIRECTORS
 
     There are five nominees for the five Board positions presently authorized
in the Company's Bylaws. Each director to be elected will hold office until the
next annual meeting of shareholders and until his successor is elected and has
qualified, or until such director's earlier death, resignation or removal.
 
     Shares represented by executed proxies will be voted, if authority to do so
is not withheld, for the election of the five nominees named below. In the event
that any nominee should be unavailable for election as a result of an unexpected
occurrence, such shares will be voted for the election of such substitute
nominee as management may propose. Each person nominated for election has agreed
to serve if elected, and management has no reason to believe that any nominee
will be unable to serve.
 
     Directors are elected by a plurality of the votes present in person or
represented by proxy and entitled to vote.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                     A VOTE IN FAVOR OF EACH NAMED NOMINEE.
 
NOMINEES
 
     The names of the nominees and certain information about them are set forth
below:
 
<TABLE>
<CAPTION>
               NAME                 AGE   PRINCIPAL OCCUPATION/POSITION HELD WITH THE COMPANY
               ----                 ---   ---------------------------------------------------
<S>                                 <C>   <C>
Frank H. Barker...................  68    Chairman, U.S. Dermatologics, Inc.
Wayne I. Roe......................  48    Chairman, Covance Health Economics and Outcomes
                                          Services, Inc.
Reid M. Rubsamen, M.D. ...........  42    Vice President, Medical Affairs and Secretary
Richard P. Thompson...............  47    President and Chief Executive Officer
Virgil D. Thompson................  58    President, Chief Executive Officer and Director of
                                          Cytel Corporation
</TABLE>
 
     FRANK H. BARKER has been the Chairman of U.S. Dermatologics, Inc., an
over-the-counter pharmaceutical company since February 1999, and was its
President and Chief Executive Officer from October 1997 to February 1999. From
January 1989 to January 1996, Mr. Barker served as a company group chairman of
Johnson & Johnson Company, a diversified health care company. Mr. Barker holds a
B.A. in Business Administration from Rollins College, Winter Park, Florida. Mr.
Barker is also a director of Catalina Marketing Corporation, a
direct-to-consumer marketing company.
 
     WAYNE I. ROE has been the Chairman of Covance Health Economics and Outcomes
Services, Inc., a contract research and developmental services company to the
medical technology marketplace, since March 1996. From June 1988 to March 1996,
Mr. Roe was the President of Health Technology Associates, a pharmaceutical
industry consulting firm. Mr. Roe received a B.A. from Union College, an M.A.
from the State University of New York at Albany and an M.A. from the University
of Maryland. He is also a director of VitaMed, Inc., a medical device
manufacturing company.
 
     REID M. RUBSAMEN, M.D., a founder of the Company, has been a director of
the Company and has served as the Company's Vice President, Medical Affairs and
Secretary since 1991. Dr. Rubsamen is a Board
 
                                        2
<PAGE>   5
 
Certified anesthesiologist having received his medical training at Pacific
Medical Center, San Francisco and Massachusetts General Hospital, where in 1989
he served as Chief Resident in Anesthesia. He was also a doctoral candidate in
the computer science department at the Massachusetts Institute of Technology,
leaving in 1990 to found the Company. Dr. Rubsamen holds an A.B. in biochemistry
and computer science from the University of California, Berkeley, and an M.S. in
computer science and an M.D. from Stanford University. Dr. Rubsamen is also a
Consulting Associate Professor of Anesthesia at Stanford University Medical
School.
 
     RICHARD P. THOMPSON has been a director of the Company and has served as
the Company's President and Chief Executive Officer since 1994 and was Chief
Financial Officer from April 1996 until December 1996. From 1991 to 1994, he was
President of LifeScan, Inc., a Johnson & Johnson Company, a medical device
manufacturing and development company. Mr. Thompson was a founder of LifeScan
and between 1981 and 1991, he held the positions of Vice President, Operations,
and later Vice President, Sales and Marketing, at LifeScan. Mr. Thompson holds a
B.S. in biological sciences from the University of California at Irvine and an
M.B.A. from California Lutheran College.
 
     VIRGIL D. THOMPSON has been a director of the Company since 1995. Since
January 1996, he has been the President and Chief Executive Officer and a
director of Cytel Corporation, a biopharmaceutical company. From 1994 to 1996,
he was President and Chief Executive Officer of Cibus Pharmaceuticals, Inc., a
drug delivery device company. From 1991 to 1993 he was President of Syntex
Laboratories, Inc. a pharmaceutical company. Mr. Thompson holds a B.S. in
Pharmacy from Kansas University and a J.D. from The George Washington University
Law School. He is also a director of two pharmaceutical companies, Biotechnology
General Corporation and Cypros Pharmaceutical Corporation.
 
BOARD COMMITTEES AND MEETINGS
 
     During the fiscal year ended December 31, 1998, the Board of Directors held
seven meetings. The Board has an Audit Committee and a Compensation Committee.
 
     The Audit Committee monitors the corporate financial reporting and the
internal and external audits of the Company, provides the Board of Directors the
results of its examinations and recommendations, outlines to the Board of
Directors the improvements made, or to be made, in internal accounting controls,
and nominates independent auditors. The Audit Committee is composed of two
non-employee directors: Burton J. McMurtry, Ph.D. and Gordon W. Russell. The
Audit Committee met twice during 1998.
 
     The Compensation Committee recommends to the Board of Directors
compensation levels for officers of the Company, establishes compensation levels
for non-officer employees of the Company, makes recommendations to the Board of
Directors regarding stock option grants under the Company's 1996 Equity
Incentive Plan (the "1996 Plan"), and otherwise administers the Plan. The
Compensation Committee is composed of two non-employee directors: Fred E.
Silverstein, M.D. and Virgil D. Thompson. The Compensation Committee met once
during 1998.
 
     During the fiscal year ended December 31, 1998, all directors attended at
least 75% of the aggregate of the meetings of the Board and of the committees on
which each served, held during the period for which each was a director or
committee member, respectively.
 
                                   PROPOSAL 2
 
               APPROVAL OF 1996 EQUITY INCENTIVE PLAN, AS AMENDED
 
     In April 1996, the Board of Directors adopted, and the shareholders
subsequently approved, the Company's 1996 Equity Incentive Plan authorizing the
issuance of 1,980,000 shares of the Company's Common Stock. An amendment to the
Company's 1996 Plan by the Board in February 1998, approved by the shareholders
in May 1998, increased the number of shares of the Company's Common Stock
authorized for issuance under the 1996 Plan from 1,980,000 shares to 2,980,000
shares.
 
     At March 31, 1999, options (net of canceled or expired options) covering an
aggregate of 1,789,214 shares of the Company's Common Stock had been granted
under the 1996 Plan, and only 180,728 shares (plus
                                        3
<PAGE>   6
 
any shares that might in the future be returned to the plans as a result of
cancellations or expiration of options) remained available for future grant
under the 1996 Plan. During the last fiscal year, under the 1996 Plan, the
Company granted to all current executive officers as a group options to purchase
30,000 shares at an exercise price of $14.25 per share and to all employees
(excluding executive officers) as a group options to purchase 975,300 shares at
exercise prices of $9.13 to $14.63 per share.
 
     In February 1999, the Board approved an amendment to the 1996 Plan, subject
to shareholder approval, to enhance the flexibility of the Board and the
Compensation Committee in granting stock options to the Company's employees. The
amendment increases the number of shares authorized for issuance under the 1996
Plan from a total of 2,980,000 shares to 4,800,000 shares of Common Stock.
 
     The Company operates in a very competitive environment with respect to the
hiring and retaining of qualified employees. The Board adopted this amendment
(i) to ensure that the Company can continue to grant stock options at levels
determined appropriate by the Board and the Compensation Committee in order to
employ the highly qualified individuals necessary for the Company's successful
growth and to retain existing employees and (ii) to meet the Company's
anticipated growth over the next two years.
 
     Shareholders are requested in this Proposal 2 to approve the 1996 Plan, as
amended. The affirmative vote of the holders of a majority of the shares present
in person or represented by proxy and voting at the meeting will be required to
approve the 1996 Plan, as amended. For purposes of this vote, abstentions and
broker non-votes will not be counted for any purpose in determining whether this
matter has been approved.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2.
 
     The essential features of the 1996 Plan are outlined below:
 
GENERAL
 
     The 1996 Plan provides for the grant of both incentive and nonstatutory
stock options. Incentive stock options granted under the 1996 Plan are intended
to qualify as "incentive stock options" within the meaning of Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"). Nonstatutory stock
options granted under the 1996 Plan are intended not to qualify as incentive
stock options under the Code. See "Federal Income Tax Information" for a
discussion of the tax treatment of incentive and nonstatutory stock options.
 
PURPOSE
 
     The 1996 Plan was adopted to provide a means by which selected officers and
employees of and consultants to the Company and its affiliates could be given an
opportunity to purchase stock in the Company, to assist in retaining the
services of employees holding key positions, to secure and retain the services
of persons capable of filling such positions and to provide incentives for such
persons to exert maximum efforts for the success of the Company. At March 31,
1999, all of the Company's approximately 156 employees and consultants were
eligible to participate in the 1996 Plan.
 
ADMINISTRATION
 
     The 1996 Plan is administered by the Board of Directors of the Company. The
Board has the power to construe and interpret the 1996 Plan and, subject to the
provisions of the 1996 Plan, to determine the persons to whom and the dates on
which options will be granted, the number of shares to be subject to each
option, the time or times during the term of each option within which all or a
portion of such option may be exercised, the exercise price, the type of
consideration and other terms of the option. The Board of Directors is
authorized to delegate administration of the 1996 Plan to a committee composed
of not fewer than two members of the Board. The Board has delegated
administration of the 1996 Plan to the Compensation Committee of the Board. As
used herein with respect to the 1996 Plan, the "Board" refers to the
Compensation Committee as well as to the Board of Directors itself. In addition,
the 1996 Plan provides that, in the Board's discretion, directors serving on the
Compensation Committee will be "outside directors" within the meaning of
                                        4
<PAGE>   7
 
Section 162(m) of the Code ("Section 162(m)"). See "Federal Income Tax
Information" for a discussion of the application of Section 162(m).
 
ELIGIBILITY
 
     Incentive stock options may be granted under the 1996 Plan only to selected
employees (including officers) of the Company and its affiliates. Selected
employees (including officers) and consultants are eligible to receive
nonstatutory stock options under the 1996 Plan. Directors who are not salaried
employees of or consultants to the Company or to any affiliate of the Company
are not eligible to participate in the 1996 Plan.
 
     No incentive stock option may be granted under the 1996 Plan to any person
who, at the time of the grant, owns (or is deemed to own) stock possessing more
than 10% of the total combined voting power of the Company or any affiliate of
the Company, unless the option exercise price is at least 110% of the fair
market value of the stock subject to the option on the date of grant, and the
term of the option does not exceed five years from the date of grant. In
addition, for incentive stock options granted under the 1996 Plan, the aggregate
fair market value, determined at the time of grant, of the shares of Common
Stock with respect to which such options are exercisable for the first time by
an optionee during any calendar year (under all such plans of the Company and
its affiliates) may not exceed $100,000.
 
STOCK SUBJECT TO THE 1996 PLAN
 
     Subject to approval of this Proposal 2 by the Company shareholders, an
aggregate of 4,800,000 shares of Common Stock are reserved for issuance under
the 1996 Plan. If options granted under the 1996 Plan expire or otherwise
terminate without being exercised, the Common Stock not purchased pursuant to
such options again becomes available for issuance under the 1996 Plan.
 
TERMS OF OPTIONS
 
     The following is a description of the permissible terms of options under
the 1996 Plan. Individual option grants may be more restrictive as to any or all
of the permissible terms described below.
 
     Exercise Price; Payment. The exercise price of incentive stock options
under the 1996 Plan may not be less than the fair market value of the Common
Stock subject to the option on the date of the option grant, and in some cases
(see "Eligibility" above), may not be less than 110% of such fair market value.
The exercise price of nonstatutory options under the 1996 Plan may not be less
than 85% of the fair market value of the Common Stock subject to the option on
the date of the option grant. However, if options were granted with exercise
prices below market value, deductions for compensation attributable to the
exercise of such options could be limited by Section 162(m). See "Federal Income
Tax Information." At March 31, 1999, the closing price of the Company's Common
Stock as reported on the Nasdaq National Market System was $9.13 per share.
 
     In the event of a decline in the value of the Company' s Common Stock, the
Board has the authority to offer employees the opportunity to replace
outstanding higher priced options, whether incentive or nonstatutory, with new
lower priced options. To the extent required by Section 162(m), an option
repriced under the 1996 Plan is deemed to be canceled and a new option granted.
 
     The exercise price of options granted under the 1996 Plan must be paid
either: (a) in cash at the time the option is exercised, or (b) at the
discretion of the Board, (i) by delivery of other Common Stock of the Company,
(ii) pursuant to a deferred payment arrangement or (c) in any other form of
legal consideration acceptable to the Board.
 
     Option Exercise. Options granted under the 1996 Plan may become exercisable
in cumulative increments ("vest") as determined by the Board. Shares covered by
currently outstanding options under the 1996 Plan granted to newly hired
employees typically vest at the rate of 25% on the one (1) year anniversary of
the vesting commencement date and in equal quarterly installments thereafter
during the optionee's employment or services as a consultant. Shares covered by
currently outstanding options under the 1996 Plan granted to existing employees
typically vest at the rate of 1/16 per quarter (25% per year) during the
optionee's
                                        5
<PAGE>   8
 
employment or services as a consultant. Shares covered by options granted in the
future under the 1996 Plan may be subject to different vesting terms. The Board
has the power to accelerate the time during which an option may be exercised. In
addition, options granted under the 1996 Plan may permit exercise prior to
vesting, but in such event the optionee may be required to enter into an early
exercise stock purchase agreement that allows the Company to repurchase shares
not yet vested at their exercise price should the optionee leave the employ of
the Company before vesting. To the extent provided by the terms of an option, an
optionee may satisfy any federal, state or local tax withholding obligation
relating to the exercise of such option by a cash payment upon exercise, by
authorizing the Company to withhold a portion of the stock otherwise issuable to
the optionee, by delivering already-owned stock of the Company or by a
combination of these means.
 
     Term. The maximum term of options under the 1996 Plan is 10 years, except
that in certain cases (see "Eligibility") the maximum term is five years.
Options under the 1996 Plan terminate three months after termination of the
optionee's employment or relationship as a consultant or director of the Company
or any affiliate of the Company, unless (a) such termination is due to such
person's disability, in which case the option may, but need not, provide that it
may be exercised at any time within 12 months of such termination; (b) the
optionee dies while employed by or serving as a consultant or director of the
Company or any affiliate of the Company, or within a period specified in the
option after termination of such relationship, in which case the option may, but
need not, provide that it may be exercised (to the extent the option was
exercisable at the time of the optionee's death) within 12 months of the
optionee's death by the person or persons to whom the rights to such option pass
by will or by the laws of descent and distribution; or (c) the option by its
terms specifically provides otherwise. Individual options by their terms may
provide for exercise within a longer period of time following termination of
employment or the consulting relationship. The option term may also be extended
in the event that exercise of the option within these periods is prohibited for
specified reasons.
 
ADJUSTMENT PROVISIONS
 
     If there is any change in the stock subject to the 1996 Plan or subject to
any option granted under the 1996 Plan (through merger, consolidation,
reorganization, recapitalization, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or otherwise), the 1996 Plan and options
outstanding thereunder will be appropriately adjusted as to the class and the
maximum number of shares subject to such plan, the maximum number of shares
which may be granted to an employee during a calendar year, and the class,
number of shares and price per share of stock subject to such outstanding
options.
 
EFFECT OF CERTAIN CORPORATE EVENTS
 
     The 1996 Plan provides that, in the event of a dissolution or liquidation
of the Company, specified type of merger or other corporate reorganization, to
the extent permitted by law, any surviving corporation will be required to
either assume options outstanding under the 1996 Plan or substitute similar
options for those outstanding under such plan, or such outstanding options will
continue in full force and effect. In the event that any surviving corporation
declines to assume or continue options outstanding under the 1996 Plan, or to
substitute similar options, then the time during which such options may be
exercised will be accelerated and the options terminated if not exercised during
such time. The acceleration of an option in the event of an acquisition or
similar corporate event may be viewed as an antitakeover provision, which may
have the effect of discouraging a proposal to acquire or otherwise obtain
control of the Company.
 
DURATION, AMENDMENT AND TERMINATION
 
     The Board may suspend or terminate the 1996 Plan without shareholder
approval or ratification at any time or from time to time. Unless sooner
terminated, the 1996 Plan will terminate on April 15, 2006.
 
     The Board may also amend the 1996 Plan at any time or from time to time.
However, no amendment will be effective unless approved by the shareholders of
the Company within 12 months before or after its adoption by the Board if the
amendment would: (a) modify the requirements as to eligibility for participation
(to the
 
                                        6
<PAGE>   9
 
extent such modification requires shareholder approval in order for the Plan to
satisfy Section 422 of the Code, if applicable, or Rule 16b-3 ("Rule 16b-3") of
the Securities Exchange Act of 1934, as amended (the "Exchange Act")); (b)
increase the number of shares reserved for issuance upon exercise of options; or
(c) change any other provision of the Plan in any other way if such modification
requires shareholder approval in order to comply with Rule 16b-3 or satisfy the
requirements of Section 422 of the Code. The Board may submit any other
amendment to the 1996 Plan for shareholder approval, including, but not limited
to, amendments intended to satisfy the requirements of Section 162(m) regarding
the exclusion of performance-based compensation from the limitation on the
deductibility of compensation paid to certain employees.
 
RESTRICTIONS ON TRANSFER
 
     Under the 1996 Plan, an incentive stock option may not be transferred by
the optionee otherwise than by will or by the laws of descent and distribution
and, during the lifetime of the optionee, may be exercised only by the optionee.
A nonstatutory stock option may not be transferred except by will or by the laws
of descent and distribution or pursuant to a domestic relations order. In any
case, the optionee may designate in writing a third party who may exercise the
option in the event of the optionee's death. In addition, shares subject to
repurchase by the Company under an early exercise stock purchase agreement may
be subject to restrictions on transfer which the Board deems appropriate.
 
FEDERAL INCOME TAX INFORMATION
 
     Incentive Stock Options. Incentive stock options under the 1996 Plan are
intended to be eligible for the favorable federal income tax treatment accorded
"incentive stock options" under the Code.
 
     There generally are no federal income tax consequences to the optionee or
the Company by reason of the grant or exercise of an incentive stock option.
However, the exercise of an incentive stock option may increase the optionee's
alternative minimum tax liability, if any.
 
     If an optionee holds stock acquired through exercise of an incentive stock
option for at least two years from the date on which the option is granted and
at least one year from the date on which the shares are transferred to the
optionee upon exercise of the option, any gain or loss on a disposition of such
stock will be long-term capital gain or loss. Generally, if the optionee
disposes of the stock before the expiration of either of these holding periods
(a "disqualifying disposition"), at the time of disposition, the optionee will
realize taxable ordinary income equal to the lesser of (a) the excess of the
stock's fair market value on the date of exercise over the exercise price, or
(b) the optionee's actual gain, if any, on the purchase and sale. The optionee's
additional gain, or any loss, upon the disqualifying disposition will be a
capital gain or loss, which will be long-term or short-term depending on whether
the stock was held for more than one year. Long-term capital gains currently are
generally subject to lower tax rates than ordinary income. The maximum capital
gains rate for federal income tax purposes is currently 28% while the maximum
ordinary income rate is effectively 39.6% at the present time. Slightly
different rules may apply to optionees who acquire stock subject to certain
repurchase options or who are subject to Section 16(b) of the Exchange Act.
 
     To the extent the optionee recognizes ordinary income by reason of a
disqualifying disposition, the Company will generally be entitled (subject to
the requirement of reasonableness, the provisions of Section 162(m) and the
satisfaction of a tax reporting obligation) to a corresponding business expense
deduction in the tax year in which the disqualifying disposition occurs.
 
     Nonstatutory Stock Options. Nonstatutory stock options granted under the
1996 Plan generally have the following federal income tax consequences: There
are no tax consequences to the optionee or the Company by reason of the grant of
a nonstatutory stock option. Upon exercise of a nonstatutory stock option, the
optionee normally will recognize taxable ordinary income equal to the excess of
the stock's fair market value on the date of exercise over the option exercise
price. Generally, with respect to employees, the Company is required to withhold
from regular wages or supplemental wage payments an amount based on the ordinary
income recognized. Subject to the requirement of reasonableness, the provisions
of Section 162(m) and the satisfaction of a tax reporting obligation, the
Company will generally be entitled to a business expense deduction equal to the
taxable ordinary income realized by the optionee. Upon disposition of the stock,
the
                                        7
<PAGE>   10
 
optionee will recognize a capital gain or loss equal to the difference between
the selling price and the sum of the amount paid for such stock plus any amount
recognized as ordinary income upon exercise of the option. Such gain or loss
will be long or short-term depending on whether the stock was held for more than
one year. Slightly different rules may apply to optionees who acquire stock
subject to certain repurchase options or who are subject to Section 16(b) of the
Exchange Act.
 
     Potential Limitation on Company Deductions. Section 162(m) denies a
deduction to any publicly held corporation for compensation paid to certain
employees in a taxable year to the extent that compensation exceeds $1,000,000
for a covered employee. It is possible that compensation attributable to stock
options, when combined with all other types of compensation received by a
covered employee from the Company, may cause this limitation to be exceeded in
any particular year.
 
     Certain kinds of compensation, including qualified "performance-based
compensation," are disregarded for purposes of the deduction limitation. In
accordance with Treasury regulations issued under Section 162(m), compensation
attributable to stock options will qualify as performance-based compensation,
provided that the option is granted by a compensation committee comprised solely
of "outside directors" and either: (i) the option plan contains a per-employee
limitation on the number of shares for which options may be granted during a
specified period, the per-employee limitation is approved by the shareholders,
and the exercise price of the option is no less than the fair market value of
the stock on the date of grant; or (ii) the option is granted (or exercisable)
only upon the achievement (as certified in writing by the compensation
committee) of an objective performance goal established in writing by the
compensation committee while the outcome is substantially uncertain, and the
option is approved by shareholders.
 
                                   PROPOSAL 3
 
              APPROVAL OF EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED
 
     In April 1996, the Board of Directors adopted, and the shareholders
subsequently approved, the Employee Stock Purchase Plan (the "Purchase Plan")
authorizing the issuance of 150,000 shares of the Company's Common Stock. An
amendment to the Company's Purchase Plan by the Board in April 1998, approved by
the shareholders in May 1998, increased the number of shares of the Company's
Common Stock authorized for issuance from 150,000 shares to 300,000 shares. At
March 31, 1999, an aggregate of 164,647 shares had been issued under the
Purchase Plan and 80,000 shares remained for the grant of future rights under
the Purchase Plan. In February 1998, the Board of Directors of the Company
adopted an amendment to the Purchase Plan to increase the number of shares
authorized for issuance under the Purchase Plan to 380,000 shares. This
amendment is intended to afford the Company greater flexibility in providing
employees with stock incentives and ensures that the Company can continue to
provide such incentives at levels determined appropriate by the Board. During
the last fiscal year, shares were purchased at prices ranging from $6.17 to
$10.74 in the following amounts under the Purchase Plan: Mr. Thompson 4,595
shares, Mr. Beers 3,161 shares, Dr. Gonda 4,096 shares, Mr. Olbert 2,852 shares,
Dr. Rubsamen 4,096 shares, all current executive officers as a group 18,800
shares, and all employees (excluding executive officers) as a group 87,887
shares.
 
     Shareholders are requested in this Proposal 3 to approve the Purchase Plan,
as amended. The affirmative vote of the holders of a majority of the shares
present in person or represented by proxy and voting at the meeting will be
required to approve the Purchase Plan, as amended. For purposes of this vote
abstentions and broker non-votes will not be counted for any purpose in
determining whether this matter has been approved.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 3.
 
                                        8
<PAGE>   11
 
     The essential features of the Purchase Plan, as amended, are outlined
below:
 
PURPOSE
 
     The purpose of the Purchase Plan is to provide a means by which key
employees of the Company (and any parent or subsidiary of the Company designated
by the Board of Directors to participate in the Purchase Plan) may be given an
opportunity to purchase Common Stock of the Company through payroll deductions,
to assist the Company in retaining the services of its employees, to secure and
retain the services of new employees, and to provide incentives for such persons
to exert maximum efforts for the success of the Company. At March 31, 1999
approximately 133 of the Company's approximately 156 employees were eligible to
participate in the Purchase Plan.
 
     The rights to purchase Common Stock granted under the Purchase Plan are
intended to qualify as options issued under an "employee stock purchase plan" as
that term is defined in Section 423(b) of the Code.
 
ADMINISTRATION
 
     The Purchase Plan is administered by the Board of Directors, which has the
final power to construe and interpret the Purchase Plan and the rights granted
under it. The Board has the power, subject to the provisions of the Purchase
Plan, to determine when and how rights to purchase Common Stock of the Company
will be granted, the provisions of each offering of such rights (which need not
be identical), and whether any parent or subsidiary of the Company shall be
eligible to participate in such plan. The Board has the power, which it has not
exercised, to delegate administration of such plan to a committee of not less
than two Board members. The Board may abolish any such committee at any time and
revest in itself the administration of the Purchase Plan.
 
OFFERINGS
 
     The Purchase Plan is implemented by offerings of rights to all eligible
employees from time to time by the Board. Generally, each such offering is two
years in duration.
 
ELIGIBILITY
 
     Any person who is customarily employed at least 20 hours per week and five
months per calendar year by the Company (or by any parent or subsidiary of the
Company designated from time to time by the Board) on the first day of an
offering period is eligible to participate in that offering under the Purchase
Plan, provided such employee has been in the continuous employ of the Company
for at least 10 days preceding the first day of the offering period.
 
     Notwithstanding the foregoing, no employee is eligible for the grant of any
rights under the Purchase Plan if, immediately after such grant, the employee
would own, directly or indirectly, stock possessing 5% or more of the total
combined voting power or value of all classes of stock of the Company or of any
parent or subsidiary of the Company (including any stock which such employee may
purchase under all outstanding rights and options), nor will any employee be
granted rights that would permit him to buy more than $25,000 worth of stock
(determined at the fair market value of the shares at the time such rights are
granted) under all employee stock purchase plans of the Company in any calendar
year.
 
PARTICIPATION IN THE PLAN
 
     Eligible employees become participants in the Purchase Plan by delivering
to the Company, prior to the date selected by the Board as the offering date for
the offering, an agreement authorizing payroll deductions of up to 15% of such
employees' total compensation during the purchase period.
 
                                        9
<PAGE>   12
 
PURCHASE PRICE
 
     The purchase price per share at which shares are sold in an offering under
the Purchase Plan is the lower of (a) 85% of the fair market value of a share of
Common Stock on the date of commencement of the offering, or (b) 85% of the fair
market value of a share of Common Stock on any purchase date.
 
PAYMENT OF PURCHASE PRICE; PAYROLL DEDUCTIONS
 
     The purchase price of the shares is accumulated by payroll deductions over
the offering period. At any time during the purchase period, a participant may
reduce or terminate his or her payroll deductions. A participant may not
increase or begin such payroll deductions after the beginning of any purchase
period, except, if the Board provides, in the case of an employee who first
becomes eligible to participate as of a date specified during the purchase
period. All payroll deductions made for a participant are credited to his or her
account under the Purchase Plan and deposited with the general funds of the
Company. A participant may not make any additional payments into such account.
 
PURCHASE OF STOCK
 
     By executing an agreement to participate in the Purchase Plan, the employee
is entitled to purchase shares under such plan. In connection with offerings
made under the Purchase Plan, the Board specifies a maximum number of shares any
employee may be granted the right to purchase and the maximum aggregate number
of shares which may be purchased pursuant to such offering by all participants.
If the aggregate number of shares to be purchased upon exercise of rights
granted in the offering would exceed the maximum aggregate number, the Board
would make a pro rata allocation of shares available in a uniform and equitable
manner. Unless the employee's participation is discontinued, his right to
purchase shares is exercised automatically at the end of the purchase period at
the applicable price. See "Withdrawal" below.
 
WITHDRAWAL
 
     While each participant in the Purchase Plan is required to sign an
agreement authorizing payroll deductions, the participant may withdraw from a
given offering by terminating his or her payroll deductions and by delivering to
the Company a notice of withdrawal from the Purchase Plan. Such withdrawal may
be elected at any time prior to the end of the applicable offering period.
 
     Upon any withdrawal from an offering by the employee, the Company will
distribute to the employee his or her accumulated payroll deductions without
interest, less any accumulated deductions previously applied to the purchase of
stock on the employee's behalf during such offering, and such employee's
interest in the offering will be automatically terminated. The employee is not
entitled to again participate in such offering. An employee's withdrawal from an
offering will not have any effect upon such employee's eligibility to
participate in subsequent offerings under the Purchase Plan.
 
TERMINATION OF EMPLOYMENT
 
     Rights granted pursuant to any offering under the Purchase Plan terminate
immediately upon cessation of an employee's employment for any reason, and the
Company will distribute to such employee all of his or her accumulated payroll
deductions, without interest.
 
RESTRICTIONS ON TRANSFER
 
     Rights granted under the Purchase Plan are not transferable and may be
exercised only by the person to whom such rights are granted.
 
DURATION, AMENDMENT AND TERMINATION
 
     The Board may suspend or terminate the Purchase Plan at any time. Unless
terminated earlier, such plan will terminate in April 2006.
 
                                       10
<PAGE>   13
 
     The Board may amend the Purchase Plan at any time. Any amendment of the
Purchase Plan must be approved by the shareholders within 12 months of its
adoption by the Board if the amendment would (a) increase the number of shares
of Common Stock reserved for issuance under the Purchase Plan, (b) modify the
requirements relating to eligibility for participation in the Purchase Plan, or
(c) modify any other provision of the Purchase Plan in a manner that would
materially increase the benefits accruing to participants under the Purchase
Plan, if such approval is required in order to comply with the requirements of
Rule 16b-3 under the Exchange Act.
 
     Rights granted before amendment or termination of the Purchase Plan will
not be altered or impaired by any amendment or termination of such plan without
consent of the person to whom such rights were granted.
 
EFFECT OF CERTAIN CORPORATE EVENTS
 
     In the event of a dissolution, liquidation or specified type of merger of
the Company, the surviving corporation either will assume the rights under the
Purchase Plan or substitute similar rights, or the exercise date of any ongoing
offering will be accelerated such that the outstanding rights may be exercised
immediately prior to, or concurrent with, any such event.
 
STOCK SUBJECT TO PURCHASE PLAN
 
     If rights granted under the Purchase Plan expire, lapse or otherwise
terminate without being exercised, the Common Stock not purchased under such
rights again becomes available for issuance under such plan.
 
FEDERAL INCOME TAX INFORMATION
 
     Rights granted under the Purchase Plan are intended to qualify for
favorable federal income tax treatment associated with rights granted under an
employee stock purchase plan which qualifies under provisions of Section 423 of
the Code.
 
     A participant will be taxed on amounts withheld for the purchase of shares
as if such amounts were actually received. Other than this, no income will be
taxable to a participant until disposition of the shares acquired, and the
method of taxation will depend upon the holding period of the purchase shares.
 
     If the stock is disposed of at least two years after the beginning of the
offering period and at least one year after the stock is transferred to the
participant, then the lesser of (a) the excess of the fair market value of the
stock at the time of such disposition over the exercise price or (b) the excess
of the fair market value of the stock as of the beginning of the offering period
over the exercise price (determined as of the beginning of the offering period)
will be treated as ordinary income. Any further gain or any loss will be taxed
as a capital gain or loss. Capital gains currently are generally subject to
lower tax rates than ordinary income.
 
     If the stock is sold or disposed of before the expiration of either of the
holding periods described above, then the excess of the fair market value of the
stock on the exercise date over the exercise price will be treated as ordinary
income at the time of such disposition, and the Company may, in the future, be
required to withhold income taxes relating to such ordinary income from other
payments made to the participant. The balance of any gain will be treated as
capital gain. Even if the stock is later disposed of for less than its fair
market value on the exercise date, the same amount of ordinary income is
attributed to the participant, and a capital loss is recognized equal to the
difference between the sales price and the fair market value of the stock on
such exercise date.
 
     There are no federal income tax consequences to the Company by reason of
the grant or exercise of rights under the Purchase Plan. The Company is entitled
to a deduction to the extent amounts are taxed as ordinary income to a
participant (subject to the requirement of reasonableness, the provisions of
Section 162(m) and the satisfaction of a tax reporting obligation).
 
                                       11
<PAGE>   14
 
NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN
 
     In addition to the 1996 Plan and the Purchase Plan, the Company has a 1996
Non-Employee Directors' Stock Option Plan (the "Directors' Plan") under which
newly elected non-employee directors of the Company receive an automatic grant
of 7,500 shares of Common Stock upon the date such person becomes a non-employee
director and under which existing non-employee directors receive automatic
grants of 7,500 on the day following each annual meeting of shareholders of the
Company (pro-rated for non-employee directors with less than a full year's
tenure). A total of 225,000 shares of Common Stock have been reserved for grant
under the Directors' Plan, of which 97,500 were issued as of March 31, 1999.
 
                                   PROPOSAL 4
 
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS
 
     The Board of Directors has selected Ernst & Young LLP as the Company's
independent auditors for the fiscal year ending December 31, 1999 and has
further directed that management submit the selection of independent auditors
for ratification by the shareholders at the Annual Meeting. Ernst & Young LLP
has audited the Company's financial statements since 1995. Representatives of
Ernst & Young LLP are expected to be present at the Annual Meeting, will have an
opportunity to make a statement if they so desire and will be available to
respond to appropriate questions.
 
     Shareholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's Bylaws or
otherwise. However, the Board is submitting the selection of Ernst & Young LLP
to the shareholders for ratification as a matter of good corporate practice. If
the shareholders fail to ratify the selection, the Audit Committee and the Board
will reconsider whether or not to retain that firm. Even if the selection is
ratified, the Audit Committee and the Board in their discretion may direct the
appointment of different independent auditors at any time during the year if
they determine that such a change would be in the best interests of the Company
and its shareholders.
 
     The affirmative vote of the holders of a majority of the shares present in
person or represented by proxy and voting at the Annual Meeting will be required
to ratify the selection of Ernst & Young LLP.
 
                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 4.
 
                                       12
<PAGE>   15
 
                             SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information regarding the ownership
of the Company's Common Stock as of March 31, 1999 by: (i) each director and
nominee for director; (ii) each of the executive officers named in the Summary
Compensation Table employed by the Company in that capacity on March 31, 1999;
(iii) all executive officers and directors of the Company as a group; and (iv)
all those known by the Company to be beneficial owners of more than five percent
(5%) of its Common Stock.
 
<TABLE>
<CAPTION>
                                                              BENEFICIAL OWNERSHIP(1)
                                                              -----------------------
                                                              NUMBER OF    PERCENT OF
                      BENEFICIAL OWNER                        SHARES(#)     TOTAL(%)
                      ----------------                        ---------    ----------
<S>                                                           <C>          <C>
Sprout Group................................................  1,073,644       7.4%
  3000 Sand Hill Road Bldg. 4
  Suite 270
  Menlo Park, CA 94025
Alliance Capital Management L.P. ...........................  1,029,100       7.0%
  The Equitable Companies, Inc.
  1290 Avenue of the Americas
  New York, NY 10104(2)
Zesiger Capital Group LLC...................................    983,100       6.7%
  320 Park Avenue, 30th Floor
  New York, NY 10022(3)
Reid M. Rubsamen, M.D.(4)...................................    353,797       2.4%
Richard P. Thompson(5)......................................    352,595       2.4%
Igor Gonda, Ph.D.(6)........................................    177,096       1.2%
R. Jerald Beers(7)..........................................    123,161         *
Mark A. Olbert(8)...........................................    109,352         *
Burton J. McMurtry, Ph.D.(9)................................     73,020         *
Virgil D. Thompson(10)......................................     27,000         *
Gordon W. Russell(11).......................................     26,411         *
Fred E. Silverstein, M.D.(12)...............................     15,000         *
Wayne I. Roe(13)............................................      8,500         *
Frank H. Barker(14).........................................      7,500         *
All executive officers and directors as a group (11           1,273,432       8.8%
  persons)(15)..............................................
</TABLE>
 
- ---------------
  *  Less than one percent.
 
 (1) Represents 640,823 shares held by Sprout Capital VII, L.P. ("Sprout VII"),
     374,125 shares held by Sprout Capital VI, L.P. ("Sprout VI") and 58,696
     shares held by DLJ Capital Corporation ("DLJCC"). DLJCC is the Managing
     General Partner of Sprout VII and Sprout VI and, as such, may be deemed to
     share voting and investment power with respect to the shares beneficially
     owned by Sprout VII and Sprout VI. Donaldson, Lufkin & Jenrette, Inc.
     ("DLJ") directly owns all of the capital stock of DLJCC and, as such, may
     be deemed to share voting and investment power with respect to the shares
     held by DLJCC, Sprout VII and Sprout VI. As of March 31, 1999, the
     Equitable Companies Incorporated ("Equitable") beneficially owns, directly
     and indirectly, 71.3% of DLJ and, as such, may be deemed to share voting
     and investment power with respect to the shares held by DLJCC, Sprout VII
     and Sprout VI.
 
 (2) This table is based upon information supplied by officers, directors and
     principal shareholders and Schedules 13D and 13G filed with the Securities
     and Exchange Commission (the "SEC"). Unless otherwise indicated in the
     footnotes to this table and subject to community property laws where
     applicable, the Company believes that each of the shareholders named in
     this table has sole voting and investment power with respect to the shares
     indicated as beneficially owned. Applicable percentages are based on
     14,599,922 shares outstanding on March 31, 1999, adjusted as required by
     rules promulgated by the SEC.
 
                                       13
<PAGE>   16
 
 (3) Represents 1,029,100 shares held by Alliance Capital Management L.P. solely
     for investment purposes on behalf of client discretionary investing
     advisory accounts.
 
 (4) Represents 983,100 shares held by Zesiger Capital Group LLC solely for
     investment purposes on behalf of client discretionary investing advisory
     accounts.
 
 (5) Includes 75,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
 (6) Represents 233,158 shares held by Mr. Thompson, 400 shares held by members
     of Mr. Thompson's immediate family, 64,037 shares held by the Thompson
     Family Trust and 15,000 shares held by Thompson Family Partners. Mr.
     Thompson is a Trustee of the Thompson Family Trust and a General Partner of
     Thompson Family Partners and, as such, may be deemed to share voting and
     investment power with respect to the shares held by the Thompson Family
     Trust and Thompson Family Partners. Mr. Thompson disclaims beneficial
     ownership of the shares held by his family members, the Thompson Family
     Trust and Thompson Family Partnership except to the extent of his pecuniary
     and proportionate partnership interest arising from his interest therein.
     Includes 140,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
 (7) Represents 121,296 shares held by Dr. Gonda and 800 shares held by members
     of Dr. Gonda's immediate family. Dr. Gonda disclaims beneficial ownership
     of such shares. Includes 55,000 shares subject to options exercisable
     within 60 days of March 31, 1999, subject to repurchase of unvested shares.
 
 (8) Includes 120,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
 (9) Includes 102,500 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(10) Represents 58,020 shares held by The McMurtry Family Trust. Mr. McMurtry, a
     director of the Company, is a Co-Trustee of The McMurtry Family Trust, and,
     as such, may be deemed to share voting and investment power with respect to
     such shares. Mr. McMurtry disclaims beneficial ownership of such shares
     except to the extent of his pecuniary interest in such shares arising from
     his interest therein. Includes 15,000 shares subject to options exercisable
     within 60 days of March 31, 1999, subject to repurchase of unvested shares.
 
(11) Represents 27,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(12) Represents 678 shares held by Mr. Russell, 8,915 shares held by Sequoia
     XXIV and 1,818 shares held by Sequoia 1995, L.L.C. Mr. Russell, a director
     of the Company, is an investment advisor of Sequoia XXIV and Sequoia 1995,
     L.L.C., and, as such, may be deemed to share voting and investment power
     with respect to such shares. Mr. Russell disclaims beneficial ownership of
     the shares held by Sequoia XXIV and Sequoia 1995, L.L.C. except to the
     extent of his pecuniary and proportionate partnership interest in such
     shares arising from his interest in the entities referred to herein.
     Includes 15,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(13) Represents 15,000 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(14) Includes 7,500 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(15) Represents 7,500 shares subject to options exercisable within 60 days of
     March 31, 1999, subject to repurchase of unvested shares.
 
(16) See Notes (1) through (15) above, as applicable.
 
                                       14
<PAGE>   17
 
            SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
     Section 16(a) of the Exchange Act requires the Company's directors and
executive officers, and persons who own more than ten percent (10%) of a
registered class of the Company's equity securities, to file with the SEC
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company. Officers, directors and greater than
ten percent (10%) shareholders are required by SEC regulation to furnish the
Company with copies of all Section 16(a) forms they file.
 
     To the Company's knowledge, based solely on a review of the copies of such
reports furnished to the Company and written representations that no other
reports were required, during the fiscal year ended December 31 1998, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than ten percent (10%) beneficial owners were complied with; except that
one report covering one transaction was filed late by each of Fred E.
Silverstein, M.D., a director of the Company, and Bikash Chatterjee, the
Company's Vice President, Operations.
 
                             EXECUTIVE COMPENSATION
 
COMPENSATION OF DIRECTORS
 
     Directors do not currently receive any cash compensation from the Company
for their service as members of the Board of Directors, although they are
reimbursed for certain expenses incurred in connection with attendance at Board
and Committee meetings in accordance with Company policy.
 
     Each non-employee director of the Company also receives stock option grants
under the Non-Employee Directors' Stock Option Plan (the "Directors' Plan").
Only non-employee directors of the Company are eligible to receive options under
the Directors' Plan. Options granted under the Directors' Plan are intended by
the Company not to qualify as incentive stock options under the Code.
 
     Option grants under the Directors' Plan are non-discretionary. On June 19
of each year (or the next business day should such date be a legal holiday)
beginning with June 19, 1997, each member of the Company's Board of Directors
who is not an employee of the Company is automatically granted under the
Directors' Plan, without further action by the Company, the Board of Directors
or the shareholders of the Company, an option to purchase 7,500 shares of Common
Stock of the Company (pro-rated for non-employee directors with less than a full
year's tenure).
 
     Options under the Directors' Plan will vest in four equal, quarterly
installments commencing on the date of grant of the option. The exercise price
of the options granted under the Directors' Plan is the fair market value of the
Common Stock granted on the date of grant. No option granted under the
Directors' Plan may be exercised after the expiration of 10 years from the date
it was granted. Options granted under the Directors' Plan are generally
non-transferable except pursuant to a qualified domestic relations order in
beneficiary descriptions. The Directors' Plan will terminate at the direction of
the Board.
 
     In the event of certain changes of control, options outstanding under the
Directors' Plan will automatically become fully vested and will terminate if not
exercised prior to such change of control.
 
     As of March 31, 1999, 97,500 options to purchase Common Stock have been
granted pursuant to the Directors' Plan and 127,500 shares remained available
for grant thereunder.
 
                                       15
<PAGE>   18
 
COMPENSATION OF EXECUTIVE OFFICERS
 
                            SUMMARY OF COMPENSATION
 
     The following table shows for the fiscal years ended December 31, 1996,
1997 and 1998, compensation awarded or paid to, or earned by, the Company's
Chief Executive Officer and its other four most highly compensated executive
officers (the "Named Executive Officers"):
 
                         SUMMARY COMPENSATION TABLE(1)
 
<TABLE>
<CAPTION>
                                                                                  LONG-TERM COMPENSATION
                                                       ANNUAL COMPENSATION                AWARDS
                                                  -----------------------------   ----------------------
                                                  FISCAL                          SECURITIES UNDERLYING
          NAME AND PRINCIPAL POSITION              YEAR    SALARY($)   BONUS($)         OPTIONS(#)
          ---------------------------             ------   ---------   --------   ----------------------
<S>                                               <C>      <C>         <C>        <C>
Richard P. Thompson.............................   1998     260,000     78,975           100,000
  President, Chief Executive                       1997     225,000     55,553            40,000
  Officer and Director                             1996     185,000     62,221           106,596
R. Jerald Beers.................................   1998     208,000     48,601                --
  Executive Vice President,                        1997      92,307         --           120,000
  Marketing and Business                           1996          --         --                --
  Development
Reid M. Rubsamen, M.D. .........................   1998     180,000     43,741            55,000
  Vice President, Medical                          1997     160,000     31,604            20,000
  Affairs, Secretary and                           1996     132,000     35,592            28,065
  Director
Igor Gonda, Ph.D. ..............................   1998     180,000     43,741            35,000
  Vice President, Research                         1997     160,000     31,604            20,000
  and Development                                  1996     144,000     39,012                --
Mark A. Olbert..................................   1998     160,000     38,881            20,000
  Vice President, Finance                          1997     162,573     28,170            65,000
  and Administration and                           1996          --         --                --
  Chief Financial Officer
</TABLE>
 
- ---------------
(1) In accordance with the rules of the Commission, the compensation described
    in this table does not include medical, group life insurance or other
    benefits received by the Named Executive Officers which are available
    generally to all salaried employees of the Company, and certain perquisites
    and other personal benefits received by the Named Executive Officers which
    do not exceed the lesser of $50,000 or 10% of any such officer's salary and
    bonus disclosed in this table.
 
                                       16
<PAGE>   19
 
                       STOCK OPTION GRANTS AND EXERCISES
 
     The Company grants options to its executive officers under its 1996 Plan.
As of March 31, 1999, options to purchase a total of 1,789,214 shares were
outstanding under the 1996 Plan and options to purchase 180,728 shares remained
available for grant thereunder.
 
     The following tables show for the fiscal year ended December 31, 1998,
certain information regarding options granted to, exercised by, and held at year
end by, the Named Executive Officers:
 
                          OPTION GRANTS IN FISCAL 1998
 
<TABLE>
<CAPTION>
                                                 INDIVIDUAL GRANTS
                                  -----------------------------------------------
                                               PERCENTAGE
                                  NUMBER OF     OF TOTAL                             POTENTIAL REALIZABLE VALUE
                                  SECURITIES    OPTIONS                               AT ASSUMED ANNUAL RATES
                                  UNDERLYING   GRANTED TO   EXERCISE                OF STOCK PRICE APPRECIATION
                                   OPTIONS     EMPLOYEES    OR BASE                      FOR OPTION TERM(3)
                                   GRANTED     IN FISCAL     PRICE     EXPIRATION   ----------------------------
              NAME                  (#)(1)     1998(%)(2)    ($/SH)       DATE        5%($)            10%($)
              ----                ----------   ----------   --------   ----------   ----------      ------------
<S>                               <C>          <C>          <C>        <C>          <C>             <C>
Richard P.Thompson..............   100,000        10.3       12.25      03/29/08      77,175           194,775
R. Jerald Beers.................        --          --          --            --          --                --
Reid M. Rubsamen, M.D...........    55,000         5.7       12.25      03/29/08     424,463         1,071,263
Igor Gonda, Ph.D................    35,000         3.6       12.25      03/29/08     270,113           681,713
Mark A. Olbert..................    20,000         2.1       12.25      03/29/08     154,350           389,550
</TABLE>
 
- ---------------
(1) Options vest quarterly over a four-year period. The options will fully vest
    upon a change of control, as defined in the 1996 Plan, unless the acquiring
    company assumes the options or substitutes similar options. The Board of
    Directors may reprice options under the terms of the 1996 Plan.
 
(2) Based on options to purchase 975,300 shares granted to employees, directors
    or consultants in 1998.
 
(3) The potential realizable value is based on the term of the option at its
    time of grant (10 years). It is calculated by assuming that the stock price
    on the date of grant appreciates at the indicated annual rate, compounded
    annually for the entire term of the option and that the option is exercised
    and sold on the last day of its term for the appreciated stock price. These
    amounts represent certain assumed rates of appreciation only, in accordance
    with the rules of the SEC, and do not reflect the Company's estimate or
    projection of future stock price performance. Actual gains, if any, are
    dependent on the actual future performance of the Company's Common Stock and
    no gain to the optionee is possible unless the stock price increases over
    the option term, which will benefit all shareholders.
 
                     VALUE OF OPTIONS AT END OF FISCAL 1998
 
<TABLE>
<CAPTION>
                                                NUMBER OF SECURITIES            VALUE OF UNEXERCISED
                                               UNDERLYING UNEXERCISED         IN-THE-MONEY OPTIONS/SARS
                                            OPTIONS/SARS AT 12/31/98 (#)           AT 12/31/98 ($)
                   NAME                     EXERCISABLE/UNEXERCISABLE(1)   EXERCISABLE/UNEXERCISABLE(1)(2)
                   ----                     ----------------------------   -------------------------------
<S>                                         <C>                            <C>
Richard P. Thompson.......................           140,000/0                       $175,000/0
R. Jerald Beers...........................           120,000/0                        660,000/0
Reid M. Rubsamen, M.D.....................            75,000/0                         88,750/0
Igor Gonda, Ph.D..........................            55,000/0                         83,750/0
Mark A. Olbert............................            85,000/0                        228,750/0
</TABLE>
 
- ---------------
(1) Reflects shares vested and unvested at December 31, 1998. Options granted
    under the 1996 Plan and the Directors' Plan are immediately exercisable, but
    are subject to the Company's right to repurchase unvested shares at the
    original exercise price paid per share upon termination of employment.
 
(2) Calculated as the fair market value of the Company's Common Stock at
    December 31, 1998 ($12.50) minus the exercise price of the options.
 
                                       17
<PAGE>   20
 
         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS
                          ON EXECUTIVE COMPENSATION(1)
 
     The Compensation Committee of the Board of Directors (the "Committee") is
composed of two non-employee directors. The Committee is responsible for setting
and administering the policies that govern annual executive salaries, bonuses
and stock option grants. The Committee annually evaluates the performance, and
determines the level of compensation, of the Chief Executive Officer ("CEO"),
and the other executive officers of the Company based upon a mix of the
achievement of the corporate goals, individual performance and comparisons with
other biotechnology companies. The CEO is not present during the discussion of
his compensation.
 
     The policies of the Committee with respect to executive officers, including
the CEO, are to provide compensation sufficient to attract, motivate and retain
executives of outstanding ability and potential and to establish an appropriate
relationship between executive compensation and the creation of shareholder
value. To meet these goals, the Committee has adopted a mix among the
compensation elements of salary, bonus and stock options, with a bias toward
stock options to emphasize the link between executive incentives and the
creation of shareholder value as measured by the equity markets.
 
     In general, the salaries of executive officers are based upon a review of
surveys of publicly-held biotechnology companies of a similar size to the
Company in terms of number of persons employed. Based upon such surveys, the
executive officers' salaries are set at the beginning of a fiscal year in the
low- to mid-range as compared to other biotechnology companies described above.
The salaries are adjusted at such time within such range based upon whether an
executive officer met specific individual performance goals. Such individual
performance goals are based upon the officer's contribution toward Company
goals. For the fiscal year ended December 31, 1998, the average increase in the
salaries of the executive officers, including the CEO, was 10.2%.
 
     Target bonuses of executive officers are based upon the surveys of other
biotechnology companies described above and are set at the beginning of each
fiscal year as a percentage of base salary, which percentage is in the mid-range
as compared to such other biotechnology companies. Actual bonuses are paid at
the end of each fiscal year and may be above or below target depending on
whether certain corporate goals have been met during the year. The set of
corporate goals is the same for all executive officers. Because the Company is a
development stage company, the corporate goals are based upon product
development and financing objectives rather than the operating performance of
the Company. The Committee assigns a weight to each goal according to whether it
was attained or surpassed. The bonus is capped at 150% of the target percentage
based on maximum goal achievement.
 
     In recommending stock options for executive officers, the Committee
considers individual performance, overall contribution to the Company and the
total number of stock options to be awarded. The level of stock option awards is
also based upon the surveys of other biotechnology companies described above.
After considering the criteria relating to awarding stock options, the Committee
determined that four executive officers, including the CEO, would receive option
grants in the fiscal year ended December 31, 1998.
 
     The Committee uses the same procedures described above for the other
executive officers in setting the annual salary, bonus and stock option awards
for the CEO, except that the CEO's salary is adjusted according to whether
corporate, rather than individual, goals are met. The corporate goals used in
adjusting the salary of the CEO are the same as the corporate goals utilized in
adjusting the bonuses of all executive officers. The CEO's salary and bonus are
determined based on comparisons with other biotechnology companies and adjusted
according to corporate performance as described above. BECAUSE MOST OF THE
CORPORATE GOALS WERE MET IN 1998, THE CEO RECEIVED AN INCREASE IN SALARY OF 16%
AND A BONUS THAT WAS 101.25% OF THE TARGET BONUS. In awarding stock options, the
Committee considers the CEO's performance, overall contribution to the Company,
the total number of options awarded and the level of options granted by other
biotechnology companies as described above. Based on such criteria, the CEO
received options to purchase an aggregate of 100,000 shares of the Company's
Common Stock for the fiscal year ended December 31, 1998. Compared to other
biotechnology companies as described above, the CEO's salary and stock options
are in the low- to mid-range.
                                       18
<PAGE>   21
 
     Section 162(m) limits the Company to a deduction for federal income tax
purposes of no more than $1 million of compensation paid to certain Named
Executive Officers during a taxable year. Compensation above $1 million may be
deducted if it is "performance-based compensation" within the meaning of the
Code. The Compensation Committee believes that at the present time it is
unlikely that the compensation paid to any Named Executive Officer in a taxable
year which is subject to the deduction limit will exceed $1 million. Therefore,
the Committee has not yet established a policy for determining which forms of
incentive compensation awarded to its Named Executive Officers shall be designed
to qualify as "performance-based compensation." The Committee intends to
continue to evaluate the effects of the statute and any United State Treasury
regulations and to comply with Section 162(m) in the future to the extent
consistent with the best interests of the Company.
 
     From the members of the Compensation Committee of Aradigm Corporation:
 
                                          Fred E. Silverstein, M.D.
                                          Virgil D. Thompson
- ---------------
 
(1) This Section is not "soliciting material," is not deemed "filed" with the
    SEC and is not to be incorporated by reference in any filing of the Company
    under the Securities Act of 1933, as amended (the "Securities Act") or the
    Exchange Act whether made before or after the date hereof and irrespective
    of any general incorporation language in any such filing.
 
                                       19
<PAGE>   22
 
                     PERFORMANCE MEASUREMENT COMPARISON(1)
 
     The following graph compares total shareholder returns of the Company since
its initial public offering of Common Stock on June 20, 1996 to two indices; the
Nasdaq CRSP Total Return Index for the Nasdaq Stock Market (U.S. companies) (the
"Nasdaq-US") and the Nasdaq Pharmaceutical Index (the "Nasdaq-Pharmaceutical").
The total return for the Company's stock and for each index assumes the
reinvestment of dividends, although dividends have never been declared on the
Company's stock, and is based on the returns of the component companies weighted
according to their capitalizations as of the end of each quarterly period. The
Nasdaq-US tracks the aggregate price performance of equity securities of U.S.
companies traded on the Nasdaq National Market (the "NM"). The
Nasdaq-Pharmaceutical tracks the aggregate price performance of equity
securities of pharmaceutical companies traded on the NM. The Company's Common
Stock is traded on the NM and is a component of both the Nasdaq-US and the
Nasdaq-Pharmaceutical.
 
  COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT SINCE THE QUARTER ENDING
                                JUNE 20, 1996(2)
                                      LOGO
- ---------------
 
(1) This Section is not "soliciting material," is not deemed "filed" with the
    SEC and is not to be incorporated by reference in any filing of the Company
    under the Securities Act or the Exchange Act whether made before or after
    the date hereof and irrespective of any general incorporation language in
    any such filing.
 
(2) Shows the cumulative total return on investment assuming an investment of
    $100 in each of the Company, the Nasdaq-US and the Nasdaq-Pharmaceutical on
    June 20, 1996. The cumulative total return on the Company's stock has been
    computed based on an initial price of $11.00 per share, the price at which
    the Company's shares were sold in its initial public offering on June 20,
    1996.
 
                              CERTAIN TRANSACTIONS
 
     In May 1994, the Company issued and sold to Richard P. Thompson, President,
Chief Executive Officer and a director of the Company, an aggregate of 225,000
shares of its Common Stock for an aggregate purchase price of $82,500, payable
pursuant to a secured promissory note bearing interest at the rate of 7% per
annum, with accrued but unpaid interest due and payable annually and the
principal and remaining interest due and payable on July 1, 1999. In February
1996, the Company issued and sold to Mr. Thompson an aggregate of
 
                                       20
<PAGE>   23
 
106,596 shares of its Common Stock for an aggregate purchase price of $60,404,
$54,364 of which was paid pursuant to a secured promissory note bearing interest
at the rate of 5.45% per annum, with the principal and accrued but unpaid
interest due and payable on February 28, 2001. The largest aggregate amount of
Mr. Thompson's indebtedness to the Company during fiscal 1998 was $128,706. The
outstanding balance of the loans to Mr. Thompson was $112,175 as of February 28,
1999.
 
     In December 1995, the Company issued and sold to Dr. Gonda, Vice President
of Research and Development of the Company, 150,000 shares of its Common Stock
for an aggregate purchase price of $65,000, $58,500 of which was paid pursuant
to a secured promissory note bearing interest at the rate of 5.91% per annum,
with the principal and accrued but unpaid interest due and payable on December
27, 2000. In October 1995, the Company loaned Dr. Gonda $90,000 pursuant to an
interest-free promissory note, with the principal amount due and payable in
October 1998. The largest aggregate amount of Dr. Gonda's indebtedness to the
Company during fiscal 1998 was $134,290. The aggregate outstanding balance of
the loans to Dr. Gonda was $44,290 as of February 28, 1999.
 
     The Company has entered into indemnity agreements with certain officers and
directors which provide, among other things, that the Company will indemnify
such officer or director, under the circumstances and to the extent provided for
therein, for expenses, damages, judgments, fines and settlements he may be
required to pay in actions or proceedings which he is or may be made a party be
reason of his position as a director, officer or other agent of the Company, and
otherwise to the full extent permitted under California law and the Company's
Bylaws.
 
     The Company believes that the foregoing transactions were in its best
interests. As a matter of policy these transactions were, and all future
transactions between the Company and any of its officers, directors or principal
shareholders will be, approved by a majority of the independent and
disinterested members of the Board of Directors, will be on terms no less
favorable to the Company than could be obtained from unaffiliated third parties
and will be in connection with bona fide business purposes of the Company.
 
                                 OTHER MATTERS
 
     The Board of Directors knows of no other matters that will be presented for
consideration at the Annual Meeting. If any other matters are properly brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote on such matters in accordance with their best judgment.
 
                                          By Order of the Board of Directors
 
                                          /s/ REID M. RUBSAMEN, M.D.
                                          --------------------------------------
                                          Reid M. Rubsamen
                                          Secretary
 
April 15, 1999
 
     A COPY OF THE COMPANY'S ANNUAL REPORT TO THE SECURITIES AND EXCHANGE
COMMISSION ON FORM 10-K FOR THE FISCAL YEAR ENDED DECEMBER 31, 1998 IS AVAILABLE
WITHOUT CHARGE UPON WRITTEN REQUEST TO: CORPORATE SECRETARY, ARADIGM
CORPORATION, 3929 POINT EDEN WAY, HAYWARD, CA 94545. COPIES MAY ALSO BE OBTAINED
WITHOUT CHARGE THROUGH THE SEC'S WORLD WIDE WEB ADDRESS AT HTTP://WWW.SEC.GOV.
 
                                       21
<PAGE>   24
 
                              ARADIGM CORPORATION
 
                          EMPLOYEE STOCK PURCHASE PLAN
 
                             ADOPTED APRIL 16, 1996
                  APPROVED BY THE SHAREHOLDERS ON JUNE 5, 1996
               AMENDED BY THE BOARD OF DIRECTORS ON APRIL 7, 1998
                  APPROVED BY THE SHAREHOLDERS ON MAY 15, 1998
             AMENDED BY THE BOARD OF DIRECTORS ON FEBRUARY 2, 1999
               APPROVED BY THE SHAREHOLDERS ON             , 1999
 
 1. PURPOSE.
 
     (a) The purpose of the Employee Stock Purchase Plan (the "Plan") is to
provide a means by which employees of Aradigm Corporation, a California
corporation (the "Company"), and its Affiliates, as defined in subparagraph
1(b), which are designated as provided in subparagraph 2(b), may be given an
opportunity to purchase stock of the Company.
 
     (b) The word "Affiliate" as used in the Plan means any parent corporation
or subsidiary corporation of the Company, as those terms are defined in Sections
424(e) and (f), respectively, of the Internal Revenue Code of 1986, as amended
(the "Code").
 
     (c) The Company, by means of the Plan, seeks to retain the services of its
employees, to secure and retain the services of new employees, and to provide
incentives for such persons to exert maximum efforts for the success of the
Company.
 
     (d) The Company intends that the rights to purchase stock of the Company
granted under the Plan be considered options issued under an "employee stock
purchase plan" as that term is defined in Section 423(b) of the Code.
 
 2. ADMINISTRATION.
 
     (a) The Plan shall be administered by the Board of Directors (the "Board")
of the Company unless and until the Board delegates administration to a
Committee, as provided in subparagraph 2(c). Whether or not the Board has
delegated administration, the Board shall have the final power to determine all
questions of policy and expediency that may arise in the administration of the
Plan.
 
     (b) The Board shall have the power, subject to, and within the limitations
of, the express provisions of the Plan:
 
          (i) To determine when and how rights to purchase stock of the Company
     shall be granted and the provisions of each offering of such rights (which
     need not be identical).
 
          (ii) To designate from time to time which Affiliates of the Company
     shall be eligible to participate in the Plan.
 
          (iii) To construe and interpret the Plan and rights granted under it,
     and to establish, amend and revoke rules and regulations for its
     administration. The Board, in the exercise of this power, may correct any
     defect, omission or inconsistency in the Plan, in a manner and to the
     extent it shall deem necessary or expedient to make the Plan fully
     effective.
 
          (iv) To amend the Plan as provided in paragraph 13.
 
          (v) Generally, to exercise such powers and to perform such acts as the
     Board deems necessary or expedient to promote the best interests of the
     Company and its Affiliates and to carry out the intent that the Plan be
     treated as an "employee stock purchase plan" within the meaning of Section
     423 of the Code.
 
     (c) The Board may delegate administration of the Plan to a Committee
composed of not fewer than two (2) members of the Board (the "Committee")
constituted in accordance with the requirements of Rule 16b-3
 
                                       22
<PAGE>   25
 
under the Exchange Act. If administration is delegated to a Committee, the
Committee shall have, in connection with the administration of the Plan, the
powers theretofore possessed by the Board, subject, however, to such
resolutions, not inconsistent with the provisions of the Plan, as may be adopted
from time to time by the Board. The Board may abolish the Committee at any time
and revest in the Board the administration of the Plan.
 
 3. SHARES SUBJECT TO THE PLAN.
 
     (a) Subject to the provisions of paragraph 12 relating to adjustments upon
changes in stock, the stock that may be sold pursuant to rights granted under
the Plan shall not exceed in the aggregate three hundred eighty thousand
(380,000) shares of the Company's common stock (the "Common Stock"). If any
right granted under the Plan shall for any reason terminate without having been
exercised, the Common Stock not purchased under such right shall again become
available for the Plan.
 
     (b) The stock subject to the Plan may be unissued shares or reacquired
shares, bought on the market or otherwise.
 
 4. GRANT OF RIGHTS; OFFERING.
 
     The Board or the Committee may from time to time grant or provide for the
grant of rights to purchase Common Stock of the Company under the Plan to
eligible employees (an "Offering") on a date or dates (the "Offering Date(s)")
selected by the Board or the Committee. Each Offering shall be in such form and
shall contain such terms and conditions as the Board or the Committee shall deem
appropriate, which shall comply with the requirements of Section 423(b)(5) of
the Code that all employees granted rights to purchase stock under the Plan
shall have the same rights and privileges. The terms and conditions of an
Offering shall be incorporated by reference into the Plan and treated as part of
the Plan. The provisions of separate Offerings need not be identical, but each
Offering shall include (through incorporation of the provisions of this Plan by
reference in the document comprising the Offering or otherwise) the period
during which the Offering shall be effective, which period shall not exceed
twenty-seven (27) months beginning with the Offering Date, and the substance of
the provisions contained in paragraphs 5 through 8, inclusive.
 
 5. ELIGIBILITY.
 
     (a) Rights may be granted only to employees of the Company or, as the Board
or the Committee may designate as provided in subparagraph 2(b), to employees of
any Affiliate of the Company. Except as provided in subparagraph 5(b), an
employee of the Company or any Affiliate shall not be eligible to be granted
rights under the Plan, unless, on the Offering Date, such employee has been in
the employ of the Company or any Affiliate for such continuous period preceding
such grant as the Board or the Committee may require, but in no event shall the
required period of continuous employment be equal to or greater than two (2)
years. In addition, unless otherwise determined by the Board or the Committee
and set forth in the terms of the applicable Offering, no employee of the
Company or any Affiliate shall be eligible to be granted rights under the Plan,
unless, on the Offering Date, such employee's customary employment with the
Company or such Affiliate is for at least twenty (20) hours per week and at
least five (5) months per calendar year.
 
     (b) The Board or the Committee may provide that, each person who, during
the course of an Offering, first becomes an eligible employee of the Company or
designated Affiliate will, on a date or dates specified in the Offering which
coincides with the day on which such person becomes an eligible employee or
occurs thereafter, receive a right under that Offering, which right shall
thereafter be deemed to be a part of that Offering. Such right shall have the
same characteristics as any rights originally granted under that Offering, as
described herein, except that:
 
          (i) the date on which such right is granted shall be the "Offering
     Date" of such right for all purposes, including determination of the
     exercise price of such right;
 
          (ii) the period of the Offering with respect to such right shall begin
     on its Offering Date and end coincident with the end of such Offering; and
 
                                       23
<PAGE>   26
 
          (iii) the Board or the Committee may provide that if such person first
     becomes an eligible employee within a specified period of time before the
     end of the Offering, he or she will not receive any right under that
     Offering.
 
     (c) No employee shall be eligible for the grant of any rights under the
Plan if, immediately after any such rights are granted, such employee owns stock
possessing five percent (5%) or more of the total combined voting power or value
of all classes of stock of the Company or of any Affiliate. For purposes of this
subparagraph 5(c), the rules of Section 424(d) of the Code shall apply in
determining the stock ownership of any employee, and stock which such employee
may purchase under all outstanding rights and options shall be treated as stock
owned by such employee.
 
     (d) An eligible employee may be granted rights under the Plan only if such
rights, together with any other rights granted under "employee stock purchase
plans" of the Company and any Affiliates, as specified by Section 423(b)(8) of
the Code, do not permit such employee's rights to purchase stock of the Company
or any Affiliate to accrue at a rate which exceeds twenty five thousand dollars
($25,000) of fair market value of such stock (determined at the time such rights
are granted) for each calendar year in which such rights are outstanding at any
time.
 
     (e) Officers of the Company and any designated Affiliate shall be eligible
to participate in Offerings under the Plan, provided, however, that the Board
may provide in an Offering that certain employees who are highly compensated
employees within the meaning of Section 423(b)(4)(D) of the Code shall not be
eligible to participate.
 
 6. RIGHTS; PURCHASE PRICE.
 
     (a) On each Offering Date, each eligible employee, pursuant to an Offering
made under the Plan, shall be granted the right to purchase up to the number of
shares of Common Stock of the Company purchasable with a percentage designated
by the Board or the Committee not exceeding fifteen percent (15%) of such
employee's Earnings (as defined by the Board or the Committee in each Offering)
during the period which begins on the Offering Date (or such later date as the
Board or the Committee determines for a particular Offering) and ends on the
date stated in the Offering, which date shall be no later than the end of the
Offering. The Board or the Committee shall establish one or more dates during an
Offering (the "Purchase Date(s)") on which rights granted under the Plan shall
be exercised and purchases of Common Stock carried out in accordance with such
Offering.
 
     (b) In connection with each Offering made under the Plan, the Board or the
Committee may specify a maximum number of shares that may be purchased by any
employee as well as a maximum aggregate number of shares that may be purchased
by all eligible employees pursuant to such Offering. In addition, in connection
with each Offering that contains more than one Purchase Date, the Board or the
Committee may specify a maximum aggregate number of shares which may be
purchased by all eligible employees on any given Purchase Date under the
Offering. If the aggregate purchase of shares upon exercise of rights granted
under the Offering would exceed any such maximum aggregate number, the Board or
the Committee shall make a pro rata allocation of the shares available in as
nearly a uniform manner as shall be practicable and as it shall deem to be
equitable.
 
     (c) The purchase price of stock acquired pursuant to rights granted under
the Plan shall be not less than the lesser of:
 
          (i) an amount equal to eighty-five percent (85%) of the fair market
     value of the stock on the Offering Date; or
 
          (ii) an amount equal to eighty-five percent (85%) of the fair market
     value of the stock on the Purchase Date.
 
                                       24
<PAGE>   27
 
 7. PARTICIPATION; WITHDRAWAL; TERMINATION.
 
     (a) An eligible employee may become a participant in the Plan pursuant to
an Offering by delivering a participation agreement to the Company within the
time specified in the Offering, in such form as the Company provides. Each such
agreement shall authorize payroll deductions of up to the maximum percentage
specified by the Board or the Committee of such employee's Earnings during the
Offering (as defined by the Board or Committee in each Offering). The payroll
deductions made for each participant shall be credited to an account for such
participant under the Plan and shall be deposited with the general funds of the
Company. A participant may reduce (including to zero) or increase such payroll
deductions, and an eligible employee may begin such payroll deductions, after
the beginning of any Offering only as provided for in the Offering. A
participant may make additional payments into his or her account only if
specifically provided for in the Offering and only if the participant has not
had the maximum amount withheld during the Offering.
 
     (b) At any time during an Offering, a participant may terminate his or her
payroll deductions under the Plan and withdraw from the Offering by delivering
to the Company a notice of withdrawal in such form as the Company provides. Such
withdrawal may be elected at any time prior to the end of the Offering except as
provided by the Board or the Committee in the Offering. Upon such withdrawal
from the Offering by a participant, the Company shall distribute to such
participant all of his or her accumulated payroll deductions (reduced to the
extent, if any, such deductions have been used to acquire stock for the
participant) under the Offering, without interest, and such participant's
interest in that Offering shall be automatically terminated. A participant's
withdrawal from an Offering will have no effect upon such participant's
eligibility to participate in any other Offerings under the Plan but such
participant will be required to deliver a new participation agreement in order
to participate in subsequent Offerings under the Plan.
 
     (c) Rights granted pursuant to any Offering under the Plan shall terminate
immediately upon cessation of any participating employee's employment with the
Company and any designated Affiliate, for any reason, and the Company shall
distribute to such terminated employee all of his or her accumulated payroll
deductions (reduced to the extent, if any, such deductions have been used to
acquire stock for the terminated employee) under the Offering, without interest.
 
     (d) Rights granted under the Plan shall not be transferable by a
participant otherwise than by will or the laws of descent and distribution, or
by a beneficiary designation as provided in paragraph 14 and, otherwise during
his or her lifetime, shall be exercisable only by the person to whom such rights
are granted.
 
 8. EXERCISE.
 
     (a) On each Purchase Date specified therefor in the relevant Offering, each
participant's accumulated payroll deductions and other additional payments
specifically provided for in the Offering (without any increase for interest)
will be applied to the purchase of whole shares of stock of the Company, up to
the maximum number of shares permitted pursuant to the terms of the Plan and the
applicable Offering, at the purchase price specified in the Offering. No
fractional shares shall be issued upon the exercise of rights granted under the
Plan. The amount, if any, of accumulated payroll deductions remaining in each
participant's account after the purchase of shares which is less than the amount
required to purchase one share of stock on the final Purchase Date of an
Offering shall be held in each such participant's account for the purchase of
shares under the next Offering under the Plan, unless such participant withdraws
from such next Offering, as provided in subparagraph 7(b), or is no longer
eligible to be granted rights under the Plan, as provided in paragraph 5, in
which case such amount shall be distributed to the participant after such final
Purchase Date, without interest. The amount, if any, of accumulated payroll
deductions remaining in any participant's account after the purchase of shares
which is equal to the amount required to purchase whole shares of stock on the
final Purchase Date of an Offering shall be distributed in full to the
participant after such Purchase Date, without interest.
 
     (b) No rights granted under the Plan may be exercised to any extent unless
the shares to be issued upon such exercise under the Plan (including rights
granted thereunder) are covered by an effective registration statement pursuant
to the Securities Act of 1933, as amended (the "Securities Act") and the Plan is
in material compliance with all applicable state, foreign and other securities
and other laws applicable to the
                                       25
<PAGE>   28
 
Plan. If on a Purchase Date in any Offering hereunder the Plan is not so
registered or in such compliance, no rights granted under the Plan or any
Offering shall be exercised on such Purchase Date, and the Purchase Date shall
be delayed until the Plan is subject to such an effective registration statement
and such compliance, except that the Purchase Date shall not be delayed more
than twelve (12) months and the Purchase Date shall in no event be more than
twenty-seven (27) months from the Offering Date. If on the Purchase Date of any
Offering hereunder, as delayed to the maximum extent permissible, the Plan is
not registered and in such compliance, no rights granted under the Plan or any
Offering shall be exercised and all payroll deductions accumulated during the
Offering (reduced to the extent, if any, such deductions have been used to
acquire stock) shall be distributed to the participants, without interest.
 
 9. COVENANTS OF THE COMPANY.
 
     (a) During the terms of the rights granted under the Plan, the Company
shall keep available at all times the number of shares of stock required to
satisfy such rights.
 
     (b) The Company shall seek to obtain from each federal, state, foreign or
other regulatory commission or agency having jurisdiction over the Plan such
authority as may be required to issue and sell shares of stock upon exercise of
the rights granted under the Plan. If, after reasonable efforts, the Company is
unable to obtain from any such regulatory commission or agency the authority
which counsel for the Company deems necessary for the lawful issuance and sale
of stock under the Plan, the Company shall be relieved from any liability for
failure to issue and sell stock upon exercise of such rights unless and until
such authority is obtained.
 
10. USE OF PROCEEDS FROM STOCK.
 
     Proceeds from the sale of stock pursuant to rights granted under the Plan
shall constitute general funds of the Company.
 
11. RIGHTS AS A SHAREHOLDER.
 
     A participant shall not be deemed to be the holder of, or to have any of
the rights of a holder with respect to, any shares subject to rights granted
under the Plan unless and until the participant's shareholdings acquired upon
exercise of rights under the Plan are recorded in the books of the Company.
 
12. ADJUSTMENTS UPON CHANGES IN STOCK.
 
     (a) If any change is made in the stock subject to the Plan, or subject to
any rights granted under the Plan (through merger, consolidation,
reorganization, recapitalization, reincorporation, stock dividend, dividend in
property other than cash, stock split, liquidating dividend, combination of
shares, exchange of shares, change in corporate structure or other transaction
not involving the receipt of consideration by the Company), the Plan and
outstanding rights will be appropriately adjusted in the class(es) and maximum
number of shares subject to the Plan and the class(es) and number of shares and
price per share of stock subject to outstanding rights. Such adjustments shall
be made by the Board or the Committee, the determination of which shall be
final, binding and conclusive. (The conversion of any convertible securities of
the Company shall not be treated as a "transaction not involving the receipt of
consideration by the Company.")
 
     (b) In the event of: (1) a dissolution or liquidation of the Company; (2) a
merger or consolidation in which the Company is not the surviving corporation;
(3) a reverse merger in which the Company is the surviving corporation but the
shares of the Company's Common Stock outstanding immediately preceding the
merger are converted by virtue of the merger into other property, whether in the
form of securities, cash or otherwise; or (4) the acquisition by any person,
entity or group within the meaning of Section 13(d) or 14(d) of the Exchange Act
or any comparable successor provisions (excluding any employee benefit plan, or
related trust, sponsored or maintained by the Company or any Affiliate of the
Company) of the beneficial ownership (within the meaning of Rule 13d-3
promulgated under the Exchange Act, or comparable successor rule) of securities
of the Company representing at least fifty percent (50%) of the combined voting
power entitled to vote in the election of directors, then, as determined by the
Board in its sole discretion (i) any surviving or
                                       26
<PAGE>   29
 
acquiring corporation may assume outstanding rights or substitute similar rights
for those under the Plan, (ii) such rights may continue in full force and
effect, or (iii) participants' accumulated payroll deductions may be used to
purchase Common Stock immediately prior to the transaction described above and
the participants' rights under the ongoing Offering terminated.
 
13. AMENDMENT OF THE PLAN.
 
     (a) The Board at any time, and from time to time, may amend the Plan.
However, except as provided in paragraph 12 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the shareholders of
the Company within twelve (12) months before or after the adoption of the
amendment, where the amendment will:
 
          (i) Increase the number of shares reserved for rights under the Plan;
 
          (ii) Modify the provisions as to eligibility for participation in the
     Plan (to the extent such modification requires shareholder approval in
     order for the Plan to obtain employee stock purchase plan treatment under
     Section 423 of the Code or to comply with the requirements of Rule 16b-3
     promulgated under the Exchange Act as amended ("Rule 16b-3")); or
 
          (iii) Modify the Plan in any other way if such modification requires
     shareholder approval in order for the Plan to obtain employee stock
     purchase plan treatment under Section 423 of the Code or to comply with the
     requirements of Rule 16b-3.
 
It is expressly contemplated that the Board may amend the Plan in any respect
the Board deems necessary or advisable to provide eligible employees with the
maximum benefits provided or to be provided under the provisions of the Code and
the regulations promulgated thereunder relating to employee stock purchase plans
and/or to bring the Plan and/or rights granted under it into compliance
therewith.
 
     (b) Rights and obligations under any rights granted before amendment of the
Plan shall not be impaired by any amendment of the Plan, except with the consent
of the person to whom such rights were granted, or except as necessary to comply
with any laws or governmental regulations, or except as necessary to ensure that
the Plan and/or rights granted under the Plan comply with the requirements of
Section 423 of the Code.
 
14. DESIGNATION OF BENEFICIARY.
 
     (a) A participant may file a written designation of a beneficiary who is to
receive any shares and cash, if any, from the participant's account under the
Plan in the event of such participant's death subsequent to the end of an
Offering but prior to delivery to the participant of such shares and cash. In
addition, a participant may file a written designation of a beneficiary who is
to receive any cash from the participant's account under the Plan in the event
of such participant's death during an Offering.
 
     (b) Such designation of beneficiary may be changed by the participant at
any time by written notice. In the event of the death of a participant and in
the absence of a beneficiary validly designated under the Plan who is living at
the time of such participant's death, the Company shall deliver such shares
and/or cash to the executor or administrator of the estate of the participant,
or if no such executor or administrator has been appointed (to the knowledge of
the Company), the Company, in its sole discretion, may deliver such shares
and/or cash to the spouse or to any one or more dependents or relatives of the
participant, or if no spouse, dependent or relative is known to the Company,
then to such other person as the Company may designate.
 
15. TERMINATION OR SUSPENSION OF THE PLAN.
 
     (a) The Board in its discretion, may suspend or terminate the Plan at any
time. No rights may be granted under the Plan while the Plan is suspended or
after it is terminated.
 
     (b) Rights and obligations under any rights granted while the Plan is in
effect shall not be impaired by suspension or termination of the Plan, except as
expressly provided in the Plan or with the consent of the person to whom such
rights were granted, or except as necessary to comply with any laws or
governmental
 
                                       27
<PAGE>   30
 
regulation, or except as necessary to ensure that the Plan and/or rights granted
under the Plan comply with the requirements of Section 423 of the Code.
 
16. EFFECTIVE DATE OF PLAN.
 
     The Plan shall become effective on the same day that the Company's initial
public offering of shares of common stock becomes effective (the "Effective
Date"), but no rights granted under the Plan shall be exercised unless and until
the Plan has been approved by the shareholders of the Company within twelve (12)
months before or after the date the Plan is adopted by the Board or the
Committee, which date may be prior to the Effective Date.
 
                                       28
<PAGE>   31
 
                              ARADIGM CORPORATION
 
                           1996 EQUITY INCENTIVE PLAN
 
               AS AMENDED AND RESTATED BY THE BOARD OF DIRECTORS
                               ON APRIL 16, 1996
                  APPROVED BY THE SHAREHOLDERS ON JUNE 5, 1996
             AMENDED BY THE BOARD OF DIRECTORS ON FEBRUARY 11, 1998
                  APPROVED BY THE SHAREHOLDERS ON MAY 15, 1998
             AMENDED BY THE BOARD OF DIRECTORS ON FEBRUARY 2, 1999
               APPROVED BY THE SHAREHOLDERS ON             , 1999
 
 1. PURPOSES.
 
     (a) The purpose of the Plan is to provide a means by which selected
Employees of and Consultants to the Company and its Affiliates may be given an
opportunity to benefit from increases in value of the stock of the Company
through the granting of (i) Incentive Stock Options, (ii) Nonstatutory Stock
Options, (iii) stock bonuses, (iv) rights to purchase restricted stock, and (v)
stock appreciation rights, all as defined below.
 
     (b) The Company, by means of the Plan, seeks to retain the services of
persons who are now Employees or Consultants, to secure and retain the services
of new Employees and Consultants, and to provide incentives for such persons to
exert maximum efforts for the success of the Company and its Affiliates.
 
     (c) The Company intends that the Stock Awards issued under the Plan shall,
in the discretion of the Board or any Committee to which responsibility for
administration of the Plan has been delegated pursuant to subsection 3(c), be
either (i) Options granted pursuant to Section 6 hereof, including Incentive
Stock Options and Nonstatutory Stock Options, (ii) stock bonuses or rights to
purchase restricted stock granted pursuant to Section 7 hereof, or (iii) stock
appreciation rights granted pursuant to Section 8 hereof. All Options shall be
separately designated Incentive Stock Options or Nonstatutory Stock Options at
the time of grant, and in such form as issued pursuant to Section 6, and a
separate certificate or certificates will be issued for shares purchased on
exercise of each type of Option.
 
 2. DEFINITIONS.
 
     (a) "AFFILIATE" means any parent corporation or subsidiary corporation,
whether now or hereafter existing, as those terms are defined in Sections 424(e)
and (f) respectively, of the Code.
 
     (b) "BOARD" means the Board of Directors of the Company.
 
     (c) "CODE" means the Internal Revenue Code of 1986, as amended.
 
     (d) "COMMITTEE" means a Committee appointed by the Board in accordance with
subsection 3(c) of the Plan.
 
     (e) "COMPANY" means Aradigm Corporation, a California corporation.
 
     (f) "CONCURRENT STOCK APPRECIATION RIGHT" or "CONCURRENT RIGHT" means a
right granted pursuant to subsection 8(b)(2) of the Plan.
 
     (g) "CONSULTANT" means any person, including an advisor, engaged by the
Company or an Affiliate to render consulting services and who is compensated for
such services, provided that the term "Consultant" shall not include Directors
who are paid only a director's fee by the Company or who are not compensated by
the Company for their services as Directors.
 
     (h) "CONTINUOUS STATUS AS AN EMPLOYEE, DIRECTOR OR CONSULTANT" means the
employment or relationship as a Director or Consultant is not interrupted or
terminated. The Board, in its sole discretion, may determine whether Continuous
Status as an Employee, Director or Consultant shall be considered interrupted in
the case of: (i) any leave of absence approved by the Board, including sick
leave, military leave, or any other personal
                                       29
<PAGE>   32
 
leave; or (ii) transfers between locations of the Company or between the
Company, Affiliates or their successors.
 
     (i) "COVERED EMPLOYEE" means the chief executive officer and the four (4)
other highest compensated officers of the Company for whom total compensation is
required to be reported to shareholders under the Exchange Act, as determined
for purposes of Section 162(m) of the Code.
 
     (j) "DIRECTOR" means a member of the Board.
 
     (k) "DISINTERESTED PERSON" means a Director who either: (i) was not during
the one year prior to service as an administrator of the Plan granted or awarded
equity securities pursuant to the Plan or any other plan of the Company or any
Affiliate entitling the participants therein to acquire equity securities of the
Company or any Affiliate except as permitted by Rule 16b-3(c)(2)(i); or (ii) is
otherwise considered to be a "disinterested person" in accordance with Rule
16b-3(c)(2)(i), or any other applicable rules, regulations or interpretations of
the Securities and Exchange Commission.
 
     (l) "EMPLOYEE" means any person, including Officers and Directors, employed
by the Company or any Affiliate of the Company. Neither service as a Director
nor payment of a director's fee by the Company shall be sufficient to constitute
"employment" by the Company.
 
     (m) "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.
 
     (n) "FAIR MARKET VALUE" means, as of any date, the value of the Common
Stock of the Company determined as follows:
 
          (1) If the Common Stock is listed on any established stock exchange or
     a national market system, including without limitation the National Market
     of The Nasdaq Stock Market, the Fair Market Value of a share of Common
     Stock shall be the closing sales price for such stock (or the closing bid,
     if no sales were reported) as quoted on such system or exchange (or the
     exchange with the greatest volume of trading in Common Stock) on the last
     market trading day prior to the day of determination, as reported in the
     Wall Street Journal or such other source as the Board deems reliable;
 
          (2) If the Common Stock is quoted on The Nasdaq Stock Market (but not
     on the National Market thereof) or is regularly quoted by a recognized
     securities dealer but selling prices are not reported, the Fair Market
     Value of a share of Common Stock shall be the mean between the bid and
     asked prices for the Common Stock on the last market trading day prior to
     the day of determination, as reported in the Wall Street Journal or such
     other source as the Board deems reliable;
 
          (3) In the absence of an established market for the Common Stock, the
     Fair Market Value shall be determined in good faith by the Board.
 
     (o) "INCENTIVE STOCK OPTION" means an Option intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code and the
regulations promulgated thereunder.
 
     (p) "INDEPENDENT STOCK APPRECIATION RIGHT" or "INDEPENDENT RIGHT" means a
right granted pursuant to subsection 8(b)(3) of the Plan.
 
     (q) "NONSTATUTORY STOCK OPTION" means an Option not intended to qualify as
an Incentive Stock Option.
 
     (r) "OFFICER" means a person who is an officer of the Company within the
meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.
 
     (s) "OPTION" means a stock option granted pursuant to the Plan.
 
     (t) "OPTION AGREEMENT" means a written agreement between the Company and an
Optionee evidencing the terms and conditions of an individual Option grant. Each
Option Agreement shall be subject to the terms and conditions of the Plan.
 
     (u) "OPTIONEE" means an Employee or Consultant who holds an outstanding
Option.
 
                                       30
<PAGE>   33
 
     (v) "OUTSIDE DIRECTOR" means a Director who either (i) is not a current
employee of the Company or an "affiliated corporation" (within the meaning of
Treasury regulations promulgated under Section 162(m) of the Code), is not a
former employee of the Company or an "affiliated corporation" receiving
compensation for prior services (other than benefits under a tax qualified
pension plan), was not an officer of the Company or an "affiliated corporation"
at any time, and is not currently receiving direct or indirect remuneration from
the Company or an "affiliated corporation" for services in any capacity other
than as a Director, or (ii) is otherwise considered an "outside director" for
purposes of Section 162(m) of the Code.
 
     (w) "PLAN" means this Aradigm Corporation 1996 Equity Incentive Plan.
 
     (x) "RULE 16B-3" means Rule 16b-3 of the Exchange Act or any successor to
Rule 16b-3, as in effect when discretion is being exercised with respect to the
Plan.
 
     (y) "STOCK APPRECIATION RIGHT" means any of the various types of rights
which may be granted under Section 8 of the Plan.
 
     (z) "STOCK AWARD" means any right granted under the Plan, including any
Option, any stock bonus, any right to purchase restricted stock, and any Stock
Appreciation Right.
 
     (aa) "STOCK AWARD AGREEMENT" means a written agreement between the Company
and a holder of a Stock Award evidencing the terms and conditions of an
individual Stock Award grant. Each Stock Award Agreement shall be subject to the
terms and conditions of the Plan.
 
     (bb) "TANDEM STOCK APPRECIATION RIGHT" or "TANDEM RIGHT" means a right
granted pursuant to subsection 8(b)(1) of the Plan.
 
 3. ADMINISTRATION.
 
     (a) The Plan shall be administered by the Board unless and until the Board
delegates administration to a Committee, as provided in subsection 3(c).
 
     (b) The Board shall have the power, subject to, and within the limitations
of, the express provisions of the Plan:
 
          (1) To determine from time to time which of the persons eligible under
     the Plan shall be granted Stock Awards; when and how each Stock Award shall
     be granted; whether a Stock Award will be an Incentive Stock Option, a
     Nonstatutory Stock Option, a stock bonus, a right to purchase restricted
     stock, a Stock Appreciation Right, or a combination of the foregoing; the
     provisions of each Stock Award granted (which need not be identical),
     including the time or times when a person shall be permitted to receive
     stock pursuant to a Stock Award; whether a person shall be permitted to
     receive stock upon exercise of an Independent Stock Appreciation Right; and
     the number of shares with respect to which a Stock Award shall be granted
     to each such person.
 
          (2) To construe and interpret the Plan and Stock Awards granted under
     it, and to establish, amend and revoke rules and regulations for its
     administration. The Board, in the exercise of this power, may correct any
     defect, omission or inconsistency in the Plan or in any Stock Award
     Agreement, in a manner and to the extent it shall deem necessary or
     expedient to make the Plan fully effective.
 
          (3) To amend the Plan or a Stock Award as provided in Section 14.
 
          (4) Generally, to exercise such powers and to perform such acts as the
     Board deems necessary or expedient to promote the best interests of the
     Company which are not in conflict with the provisions of the Plan.
 
     (c) The Board may delegate administration of the Plan to a committee
composed of not fewer than two (2) members (the "Committee"), all of the members
of which Committee shall be Disinterested Persons and may also be, in the
discretion of the Board, Outside Directors. If administration is delegated to a
Committee, the Committee shall have, in connection with the administration of
the Plan, the powers theretofore possessed by the Board (and references in this
Plan to the Board shall thereafter be to the Committee), subject,
 
                                       31
<PAGE>   34
 
however, to such resolutions, not inconsistent with the provisions of the Plan,
as may be adopted from time to time by the Board. The Board may abolish the
Committee at any time and revest in the Board the administration of the Plan.
Notwithstanding anything in this Section 3 to the contrary, at any time the
Board or the Committee may delegate to a committee of one or more members of the
Board the authority to grant Stock Awards to eligible persons who (1) are not
then subject to Section 16 of the Exchange Act and/or (2) are either (i) not
then Covered Employees and are not expected to be Covered Employees at the time
of recognition of income resulting from such Stock Award, or (ii) not persons
with respect to whom the Company wishes to avoid the application of Section
162(m) of the Code.
 
     (d) Any requirement that an administrator of the Plan be a Disinterested
Person shall not apply if the Board or the Committee expressly declares that
such requirement shall not apply. Any Disinterested Person shall otherwise
comply with the requirements of Rule 16b-3.
 
 4. SHARES SUBJECT TO THE PLAN.
 
     (a) Subject to the provisions of Section 13 relating to adjustments upon
changes in stock, the stock that may be issued pursuant to Stock Awards shall
not exceed in the aggregate four million eight hundred thousand (4,800,000)
shares of the Company's Common Stock. If any Stock Award shall for any reason
expire or otherwise terminate, in whole or in part, without having been
exercised in full, the stock not acquired under such Stock Award shall revert to
and again become available for issuance under the Plan. Shares subject to Stock
Appreciation Rights exercised in accordance with Section 8 of the Plan shall not
be available for subsequent issuance under the Plan.
 
     (b) The stock subject to the Plan may be unissued shares or reacquired
shares, bought on the market or otherwise.
 
 5. ELIGIBILITY.
 
     (a) Incentive Stock Options and Stock Appreciation Rights appurtenant
thereto may be granted only to Employees. Stock Awards other than Incentive
Stock Options and Stock Appreciation Rights appurtenant thereto may be granted
only to Employees or Consultants.
 
     (b) A Director shall in no event be eligible for the benefits of the Plan
unless at the time of grant the Director is also an Employee or Consultant.
 
     (c) No person shall be eligible for the grant of an Incentive Stock Option
if, at the time of grant, such person owns (or is deemed to own pursuant to
Section 424(d) of the Code) stock possessing more than ten percent (10%) of the
total combined voting power of all classes of stock of the Company or of any of
its Affiliates unless the exercise price of such Option is at least one hundred
ten percent (110%) of the Fair Market Value of such stock at the date of grant
and the Option is not exercisable after the expiration of five (5) years from
the date of grant, or in the case of a restricted stock purchase award, the
purchase price is at least one hundred percent (100%) of the Fair Market Value
of such stock at the date of grant.
 
 6. OPTION PROVISIONS.
 
     Each Option shall be in such form and shall contain such terms and
conditions as the Board shall deem appropriate. The provisions of separate
Options need not be identical, but each Option shall include (through
incorporation of provisions hereof by reference in the Option or otherwise) the
substance of each of the following provisions:
 
     (a) TERM. No Option shall be exercisable after the expiration of ten (10)
years from the date it was granted.
 
     (b) PRICE. The exercise price of each Incentive Stock Option shall be not
less than one hundred percent (100%) of the Fair Market Value of the stock
subject to the Option on the date the Option is granted, and the exercise price
of a Nonstatutory Stock Option shall be not less than eighty-five percent (85%)
of the Fair Market Value of the stock subject to the Option on the date the
Option is granted. Notwithstanding the
 
                                       32
<PAGE>   35
 
foregoing, an Incentive Stock Option may be granted with an exercise price lower
than that set forth in the preceding sentence if such Option is granted pursuant
to an assumption or substitution for another option in a manner satisfying the
provisions of Section 424(a) of the Code.
 
     (c) CONSIDERATION. The purchase price of stock acquired pursuant to an
Option shall be paid, to the extent permitted by applicable statutes and
regulations, either (i) in cash at the time the Option is exercised, or (ii) at
the discretion of the Board or the Committee, at the time of the grant of the
Option, (A) by delivery to the Company of other Common Stock of the Company, (B)
according to a deferred payment or other arrangement (which may include, without
limiting the generality of the foregoing, the use of other Common Stock of the
Company) with the person to whom the Option is granted or to whom the Option is
transferred pursuant to subsection 6(d), or (C) in any other form of legal
consideration that may be acceptable to the Board.
 
     In the case of any deferred payment arrangement, interest shall be payable
at least annually and shall be charged at the minimum rate of interest necessary
to avoid the treatment as interest, under any applicable provisions of the Code,
of any amounts other than amounts stated to be interest under the deferred
payment arrangement.
 
     (d) TRANSFERABILITY. An Incentive Stock Option shall not be transferable
except by will or by the laws of descent and distribution, and shall be
exercisable during the lifetime of the person to whom the Incentive Stock Option
is granted only by such person. A Nonstatutory Stock Option shall not be
transferable except by will, by the laws of descent and distribution or pursuant
to a qualified domestic relations order satisfying the requirements of Rule
16b-3 and any administrative interpretations or pronouncements thereunder (a
"QDRO"), and shall be exercisable during the lifetime of the person to whom the
Option is granted only by such person or any transferee pursuant to a QDRO.
Notwithstanding the foregoing, the person to whom the Option is granted may, by
delivering written notice to the Company, in a form satisfactory to the Company,
designate a third party who, in the event of the death of the Optionee, shall
thereafter be entitled to exercise the Option.
 
     (e) VESTING. The total number of shares of stock subject to an Option may,
but need not, be allotted in periodic installments (which may, but need not, be
equal). The Option Agreement may provide that from time to time during each of
such installment periods, the Option may become exercisable ("vest") with
respect to some or all of the shares allotted to that period, and may be
exercised with respect to some or all of the shares allotted to such period
and/or any prior period as to which the Option became vested but was not fully
exercised. The Option may be subject to such other terms and conditions on the
time or times when it may be exercised (which may be based on performance or
other criteria) as the Board may deem appropriate. The provisions of this
subsection 6(e) are subject to any Option provisions governing the minimum
number of shares as to which an Option may be exercised.
 
     (f) TERMINATION OF EMPLOYMENT OR RELATIONSHIP AS A DIRECTOR OR
CONSULTANT. In the event an Optionee's Continuous Status as an Employee,
Director or Consultant terminates (other than upon the Optionee's death or
disability), the Optionee may exercise his or her Option (to the extent that the
Optionee was entitled to exercise it at the date of termination) but only within
such period of time ending on the earlier of (i) the date three (3) months after
the termination of the Optionee's Continuous Status as an Employee, Director or
Consultant (or such longer or shorter period specified in the Option Agreement),
or (ii) the expiration of the term of the Option as set forth in the Option
Agreement. If, after termination, the Optionee does not exercise his or her
Option within the time specified in the Option Agreement, the Option shall
terminate, and the shares covered by such Option shall revert to and again
become available for issuance under the Plan.
 
     An Optionee's Option Agreement may also provide that if the exercise of the
Option following the termination of the Optionee's Continuous Status as an
Employee, Director, or Consultant (other than upon the Optionee's death or
disability) would result in liability under Section 16(b) of the Exchange Act,
then the Option shall terminate on the earlier of (i) the expiration of the term
of the Option set forth in the Option Agreement, or (ii) the tenth (10th) day
after the last date on which such exercise would result in such liability under
Section 16(b) of the Exchange Act. Finally, an Optionee's Option Agreement may
also provide
                                       33
<PAGE>   36
 
that if the exercise of the Option following the termination of the Optionee's
Continuous Status as an Employee, Director or Consultant (other than upon the
Optionee's death or disability) would be prohibited at any time solely because
the issuance of shares would violate the registration requirements under the
Act, then the Option shall terminate on the earlier of (i) the expiration of the
term of the Option set forth in the first paragraph of this subsection 6(f), or
(ii) the expiration of a period of three (3) months after the termination of the
Optionee's Continuous Status as an Employee, Director or Consultant during which
the exercise of the Option would not be in violation of such registration
requirements.
 
     (g) DISABILITY OF OPTIONEE. In the event an Optionee's Continuous Status as
an Employee, Director or Consultant terminates as a result of the Optionee's
disability, the Optionee may exercise his or her Option (to the extent that the
Optionee was entitled to exercise it at the date of termination), but only
within such period of time ending on the earlier of (i) the date twelve (12)
months following such termination (or such longer or shorter period specified in
the Option Agreement), or (ii) the expiration of the term of the Option as set
forth in the Option Agreement. If, at the date of termination, the Optionee is
not entitled to exercise his or her entire Option, the shares covered by the
unexercisable portion of the Option shall revert to and again become available
for issuance under the Plan. If, after termination, the Optionee does not
exercise his or her Option within the time specified herein, the Option shall
terminate, and the shares covered by such Option shall revert to and again
become available for issuance under the Plan.
 
     (h) DEATH OF OPTIONEE. In the event of the death of an Optionee during, or
within a period specified in the Option after the termination of, the Optionee's
Continuous Status as an Employee, Director or Consultant, the Option may be
exercised (to the extent the Optionee was entitled to exercise the Option at the
date of death) by the Optionee's estate, by a person who acquired the right to
exercise the Option by bequest or inheritance or by a person designated to
exercise the option upon the Optionee's death pursuant to subsection 6(d), but
only within the period ending on the earlier of (i) the date twelve (12) months
following the date of death (or such longer or shorter period specified in the
Option Agreement), or (ii) the expiration of the term of such Option as set
forth in the Option Agreement. If, at the time of death, the Optionee was not
entitled to exercise his or her entire Option, the shares covered by the
unexercisable portion of the Option shall revert to and again become available
for issuance under the Plan. If, after death, the Option is not exercised within
the time specified herein, the Option shall terminate, and the shares covered by
such Option shall revert to and again become available for issuance under the
Plan.
 
     (i) EARLY EXERCISE. The Option may, but need not, include a provision
whereby the Optionee may elect at any time while an Employee, Director or
Consultant to exercise the Option as to any part or all of the shares subject to
the Option prior to the full vesting of the Option. Any unvested shares so
purchased may be subject to a repurchase right in favor of the Company or to any
other restriction the Board determines to be appropriate.
 
     (j) RE-LOAD OPTIONS. Without in any way limiting the authority of the Board
or Committee to make or not to make grants of Options hereunder, the Board or
Committee shall have the authority (but not an obligation) to include as part of
any Option Agreement a provision entitling the Optionee to a further Option (a
"Re-Load Option") in the event the Optionee exercises the Option evidenced by
the Option agreement, in whole or in part, by surrendering other shares of
Common Stock in accordance with this Plan and the terms and conditions of the
Option Agreement. Any such Re-Load Option (i) shall be for a number of shares
equal to the number of shares surrendered as part or all of the exercise price
of such Option; (ii) shall have an expiration date which is the same as the
expiration date of the Option the exercise of which gave rise to such Re-Load
Option; and (iii) shall have an exercise price which is equal to one hundred
percent (100%) of the Fair Market Value of the Common Stock subject to the
Re-Load Option on the date of exercise of the original Option. Notwithstanding
the foregoing, a Re-Load Option which is an Incentive Stock Option and which is
granted to a 10% shareholder (as described in subsection 5(c)), shall have an
exercise price which is equal to one hundred ten percent (110%) of the Fair
Market Value of the stock subject to the Re-Load Option on the date of exercise
of the original Option and shall have a term which is no longer than five (5)
years.
 
     Any such Re-Load Option may be an Incentive Stock Option or a Nonstatutory
Stock Option, as the Board or Committee may designate at the time of the grant
of the original Option; provided, however, that the
 
                                       34
<PAGE>   37
 
designation of any Re-Load Option as an Incentive Stock Option shall be subject
to the one hundred thousand dollar ($100,000) annual limitation on
exercisability of Incentive Stock Options described in subsection 12(d) of the
Plan and in Section 422(d) of the Code. There shall be no Re-Load Options on a
Re-Load Option. Any such Re-Load Option shall be subject to the availability of
sufficient shares under subsection 4(a) and shall be subject to such other terms
and conditions as the Board or Committee may determine which are not
inconsistent with the express provisions of the Plan regarding the terms of
Options.
 
 7. TERMS OF STOCK BONUSES AND PURCHASES OF RESTRICTED STOCK.
 
     Each stock bonus or restricted stock purchase agreement shall be in such
form and shall contain such terms and conditions as the Board or the Committee
shall deem appropriate. The terms and conditions of stock bonus or restricted
stock purchase agreements may change from time to time, and the terms and
conditions of separate agreements need not be identical, but each stock bonus or
restricted stock purchase agreement shall include (through incorporation of
provisions hereof by reference in the agreement or otherwise) the substance of
each of the following provisions as appropriate:
 
     (a) PURCHASE PRICE. The purchase price under each restricted stock purchase
agreement shall be such amount as the Board or Committee shall determine and
designate in such agreement but in no event shall the purchase price be less
than eighty-five percent (85%) of the stock's Fair Market Value on the date such
award is made. Notwithstanding the foregoing, the Board or the Committee may
determine that eligible participants in the Plan may be awarded stock pursuant
to a stock bonus agreement in consideration for past services actually rendered
to the Company for its benefit.
 
     (b) TRANSFERABILITY. No rights under a stock bonus or restricted stock
purchase agreement shall be transferable except by will or the laws of descent
and distribution or pursuant to a qualified domestic relations order satisfying
the requirements of Rule 16b-3 and any administrative interpretations or
pronouncements thereunder, so long as stock awarded under such agreement remains
subject to the terms of the agreement.
 
     (c) CONSIDERATION. The purchase price of stock acquired pursuant to a stock
purchase agreement shall be paid either: (i) in cash at the time of purchase;
(ii) at the discretion of the Board or the Committee, according to a deferred
payment or other arrangement with the person to whom the stock is sold; or (iii)
in any other form of legal consideration that may be acceptable to the Board or
the Committee in its discretion. Notwithstanding the foregoing, the Board or the
Committee to which administration of the Plan has been delegated may award stock
pursuant to a stock bonus agreement in consideration for past services actually
rendered to the Company or for its benefit.
 
     (d) VESTING. Shares of stock sold or awarded under the Plan may, but need
not, be subject to a repurchase option in favor of the Company in accordance
with a vesting schedule to be determined by the Board or the Committee.
 
     (e) TERMINATION OF EMPLOYMENT OR RELATIONSHIP AS A DIRECTOR OR
CONSULTANT. In the event a Participant's Continuous Status as an Employee,
Director or Consultant terminates, the Company may repurchase or otherwise
reacquire any or all of the shares of stock held by that person which have not
vested as of the date of termination under the terms of the stock bonus or
restricted stock purchase agreement between the Company and such person.
 
 8. STOCK APPRECIATION RIGHTS.
 
     (a) The Board or Committee shall have full power and authority, exercisable
in its sole discretion, to grant Stock Appreciation Rights under the Plan to
Employees and Consultants. To exercise any outstanding Stock Appreciation Right,
the holder must provide written notice of exercise to the Company in compliance
with the provisions of the Stock Award Agreement evidencing such right. If a
Stock Appreciation Right is granted to an individual who is at the time subject
to Section 16(b) of the Exchange Act (a "Section 16(b) Insider"), the Stock
Award Agreement of grant shall incorporate all the terms and conditions at the
time necessary to assure that the subsequent exercise of such right shall
qualify for the safe-harbor exemption from short-swing profit liability provided
by Rule 16b-3 promulgated under the Exchange Act (or any successor
 
                                       35
<PAGE>   38
 
rule or regulation). No limitation shall exist on the aggregate amount of cash
payments the Company may make under the Plan in connection with the exercise of
a Stock Appreciation Rights.
 
     (b) Three types of Stock Appreciation Rights shall be authorized for
issuance under the Plan:
 
          (1) TANDEM STOCK APPRECIATION RIGHTS. Tandem Stock Appreciation Rights
     will be granted appurtenant to an Option, and shall, except as specifically
     set forth in this Section 8, be subject to the same terms and conditions
     applicable to the particular Option grant to which it pertains. Tandem
     Stock Appreciation Rights will require the holder to elect between the
     exercise of the underlying Option for shares of stock and the surrender, in
     whole or in part, of such Option for an appreciation distribution. The
     appreciation distribution payable on the exercised Tandem Right shall be in
     cash (or, if so provided, in an equivalent number of shares of stock based
     on Fair Market Value on the date of the Option surrender) in an amount up
     to the excess of (A) the Fair Market Value (on the date of the Option
     surrender) of the number of shares of stock covered by that portion of the
     surrendered Option in which the Optionee is vested over (B) the aggregate
     exercise price payable for such vested shares.
 
          (2) CONCURRENT STOCK APPRECIATION RIGHTS. Concurrent Rights will be
     granted appurtenant to an Option and may apply to all or any portion of the
     shares of stock subject to the underlying Option and shall, except as
     specifically set forth in this Section 8, be subject to the same terms and
     conditions applicable to the particular Option grant to which it pertains.
     A Concurrent Right shall be exercised automatically at the same time the
     underlying Option is exercised with respect to the particular shares of
     stock to which the Concurrent Right pertains. The appreciation distribution
     payable on an exercised Concurrent Right shall be in cash (or, if so
     provided, in an equivalent number of shares of stock based on Fair Market
     Value on the date of the exercise of the Concurrent Right) in an amount
     equal to such portion as shall be determined by the Board or the Committee
     at the time of the grant of the excess of (A) the aggregate Fair Market
     Value (on the date of the exercise of the Concurrent Right) of the vested
     shares of stock purchased under the underlying Option which have Concurrent
     Rights appurtenant to them over (B) the aggregate exercise price paid for
     such shares.
 
          (3) INDEPENDENT STOCK APPRECIATION RIGHTS. Independent Rights will be
     granted independently of any Option and shall, except as specifically set
     forth in this Section 8, be subject to the same terms and conditions
     applicable to Nonstatutory Stock Options as set forth in Section 6. They
     shall be denominated in share equivalents. The appreciation distribution
     payable on the exercised Independent Right shall be not greater than an
     amount equal to the excess of (A) the aggregate Fair Market Value (on the
     date of the exercise of the Independent Right) of a number of shares of
     Company stock equal to the number of share equivalents in which the holder
     is vested under such Independent Right, and with respect to which the
     holder is exercising the Independent Right on such date, over (B) the
     aggregate Fair Market Value (on the date of the grant of the Independent
     Right) of such number of shares of Company stock. The appreciation
     distribution payable on the exercised Independent Right shall be in cash
     or, if so provided, in an equivalent number of shares of stock based on
     Fair Market Value on the date of the exercise of the Independent Right.
 
 9. CANCELLATION AND RE-GRANT OF OPTIONS.
 
     The Board or the Committee shall have the authority to effect, at any time
and from time to time, (i) the repricing of any outstanding Options and/or any
Stock Appreciation Rights under the Plan and/or (ii) with the consent of any
adversely affected holders of Options and/or Stock Appreciation Rights, the
cancellation of any outstanding Options and/or any Stock Appreciation Rights
under the Plan and the grant in substitution therefor of new Options and/or
Stock Appreciation Rights under the Plan covering the same or different numbers
of shares of stock, but having an exercise price per share not less than:
eighty-five percent (85%) of the Fair Market Value for a Nonstatutory Stock
Option, one hundred percent (100%) of the Fair Market Value in the case of an
Incentive Stock Option or, in the case of an Incentive Stock Option held by a
10% shareholder (as described in subsection 5(c)), not less than one hundred ten
percent (110%) of the Fair Market Value per share of stock on the new grant
date. Notwithstanding the foregoing, the Board or the Committee may grant an
Option and/or Stock Appreciation Right with an exercise price lower than that
set
 
                                       36
<PAGE>   39
 
forth above if such Option and/or Stock Appreciation Right is granted as part of
a transaction to which section 424(a) of the Code applies.
 
10. COVENANTS OF THE COMPANY.
 
     (a) During the terms of the Stock Awards, the Company shall keep available
at all times the number of shares of stock required to satisfy such Stock
Awards.
 
     (b) The Company shall seek to obtain from each regulatory commission or
agency having jurisdiction over the Plan such authority as may be required to
issue and sell shares of stock upon exercise of the Stock Award; provided,
however, that this undertaking shall not require the Company to register under
the Securities Act of 1933, as amended (the "Securities Act") either the Plan,
any Stock Award or any stock issued or issuable pursuant to any such Stock
Award. If, after reasonable efforts, the Company is unable to obtain from any
such regulatory commission or agency the authority which counsel for the Company
deems necessary for the lawful issuance and sale of stock under the Plan, the
Company shall be relieved from any liability for failure to issue and sell stock
upon exercise of such Stock Awards unless and until such authority is obtained.
 
11. USE OF PROCEEDS FROM STOCK.
 
     Proceeds from the sale of stock pursuant to Stock Awards shall constitute
general funds of the Company.
 
12. MISCELLANEOUS.
 
     (a) The Board shall have the power to accelerate the time at which a Stock
Award may first be exercised or the time during which a Stock Award or any part
thereof will vest pursuant to subsection 6(e), 7(d) or 8(b), notwithstanding the
provisions in the Stock Award stating the time at which it may first be
exercised or the time during which it will vest.
 
     (b) Neither an Employee, a Consultant nor any person to whom a Stock Award
is transferred in accordance with the Plan shall be deemed to be the holder of,
or to have any of the rights of a holder with respect to, any shares subject to
such Stock Award unless and until such person has satisfied all requirements for
exercise of the Stock Award pursuant to its terms.
 
     (c) Nothing in the Plan or any instrument executed or Stock Award granted
pursuant thereto shall confer upon any Employee, Consultant or other holder of
Stock Awards any right to continue in the employ of the Company or any Affiliate
or to continue acting as a Consultant or shall affect the right of the Company
or any Affiliate to terminate the employment of any Employee with or without
notice and with or without cause, or the right to terminate the relationship of
any Consultant pursuant to the terms of such Consultant's agreement with the
Company or Affiliate.
 
     (d) To the extent that the aggregate Fair Market Value (determined at the
time of grant) of stock with respect to which Incentive Stock Options are
exercisable for the first time by any Optionee during any calendar year under
all plans of the Company and its Affiliates exceeds one hundred thousand dollars
($100,000), the Options or portions thereof which exceed such limit (according
to the order in which they were granted) shall be treated as Nonstatutory Stock
Options.
 
     (e) The Company may require any person to whom a Stock Award is granted, or
any person to whom a Stock Award is transferred in accordance with the Plan, as
a condition of exercising or acquiring stock under any Stock Award, (1) to give
written assurances satisfactory to the Company as to such person's knowledge and
experience in financial and business matters and/or to employ a purchaser
representative reasonably satisfactory to the Company who is knowledgeable and
experienced in financial and business matters, and that he or she is capable of
evaluating, alone or together with the purchaser representative, the merits and
risks of exercising the Stock Award; and (2) to give written assurances
satisfactory to the Company stating that such person is acquiring the stock
subject to the Stock Award for such person's own account and not with any
present intention of selling or otherwise distributing the stock. The foregoing
requirements, and any assurances given pursuant to such requirements, shall be
inoperative if (i) the issuance of the shares upon the exercise or
                                       37
<PAGE>   40
 
acquisition of stock under the Stock Award has been registered under a then
currently effective registration statement under the Securities Act, or (ii) as
to any particular requirement, a determination is made by counsel for the
Company that such requirement need not be met in the circumstances under the
then applicable securities laws. The Company may, upon advice of counsel to the
Company, place legends on stock certificates issued under the Plan as such
counsel deems necessary or appropriate in order to comply with applicable
securities laws, including, but not limited to, legends restricting the transfer
of the stock.
 
     (f) To the extent provided by the terms of a Stock Award Agreement, the
person to whom a Stock Award is granted may satisfy any federal, state or local
tax withholding obligation relating to the exercise or acquisition of stock
under a Stock Award by any of the following means or by a combination of such
means: (1) tendering a cash payment; (2) authorizing the Company to withhold
shares from the shares of the Common Stock otherwise issuable to the participant
as a result of the exercise or acquisition of stock under the Stock Award; or
(3) delivering to the Company owned and unencumbered shares of the Common Stock
of the Company.
 
13. ADJUSTMENTS UPON CHANGES IN STOCK.
 
     (a) If any change is made in the stock subject to the Plan, or subject to
any Stock Award, without the receipt of consideration by the Company (through
merger, consolidation, reorganization, recapitalization, reincorporation, stock
dividend, dividend in property other than cash, stock split, liquidating
dividend, combination of shares, exchange of shares, change in corporate
structure or other transaction not involving the receipt of consideration by the
Company), the Plan will be appropriately adjusted in the class(es) and maximum
number of shares subject to the Plan pursuant to subsection 4(a), and the
outstanding Stock Awards will be appropriately adjusted in the class(es) and
number of shares and price per share of stock subject to such outstanding Stock
Awards. Such adjustments shall be made by the Board or the Committee, the
determination of which shall be final, binding and conclusive. (The conversion
of any convertible securities of the Company shall not be treated as a
"transaction not involving the receipt of consideration by the Company".)
 
     (b) In the event of: (1) a dissolution, liquidation or sale of
substantially all of the assets of the Company; (2) a merger or consolidation in
which the Company is not the surviving corporation; or (3) a reverse merger in
which the Company is the surviving corporation but the shares of the Company's
Common Stock outstanding immediately preceding the merger are converted by
virtue of the merger into other property, whether in the form of securities,
cash or otherwise, then to the extent permitted by applicable law: (i) any
surviving corporation or an Affiliate of such surviving corporation shall assume
any Stock Awards outstanding under the Plan or shall substitute similar Stock
Awards for those outstanding under the Plan, or (ii) such Stock Awards shall
continue in full force and effect. In the event any surviving corporation and
its Affiliates refuse to assume or continue such Stock Awards, or to substitute
similar options for those outstanding under the Plan, then, with respect to
Stock Awards held by persons then performing services as Employees, Directors or
Consultants, the time during which such Stock Awards may be exercised shall be
accelerated and the Stock Awards terminated if not exercised prior to such
event.
 
14. AMENDMENT OF THE PLAN AND STOCK AWARDS.
 
     (a) The Board at any time, and from time to time, may amend the Plan.
However, except as provided in Section 13 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the shareholders of
the Company within twelve (12) months before or after the adoption of the
amendment, where the amendment will:
 
          (i) Increase the number of shares reserved for Stock Awards under the
     Plan;
 
          (ii) Modify the requirements as to eligibility for participation in
     the Plan (to the extent such modification requires shareholder approval in
     order for the Plan to satisfy the requirements of Section 422 of the Code);
     or
 
                                       38
<PAGE>   41
 
          (iii) Modify the Plan in any other way if such modification requires
     shareholder approval in order for the Plan to satisfy the requirements of
     Section 422 of the Code or to comply with the requirements of Rule 16b-3.
 
     (b) The Board may in its sole discretion submit any other amendment to the
Plan for shareholder approval, including, but not limited to, amendments to the
Plan intended to satisfy the requirements of Section 162(m) of the Code and the
regulations promulgated thereunder regarding the exclusion of performance-based
compensation from the limit on corporate deductibility of compensation paid to
certain executive officers.
 
     (c) It is expressly contemplated that the Board may amend the Plan in any
respect the Board deems necessary or advisable to provide eligible Employees or
Consultants with the maximum benefits provided or to be provided under the
provisions of the Code and the regulations promulgated thereunder relating to
Incentive Stock Options and/or to bring the Plan and/or Incentive Stock Options
granted under it into compliance therewith.
 
     (d) Rights and obligations under any Stock Award granted before amendment
of the Plan shall not be impaired by any amendment of the Plan unless (i) the
Company requests the consent of the person to whom the Stock Award was granted
and (ii) such person consents in writing.
 
     (e) The Board at any time, and from time to time, may amend the terms of
any one or more Stock Award; provided, however, that the rights and obligations
under any Stock Award shall not be impaired by any such amendment unless (i) the
Company requests the consent of the person to whom the Stock Award was granted
and (ii) such person consents in writing.
 
15. TERMINATION OR SUSPENSION OF THE PLAN.
 
     (a) The Board may suspend or terminate the Plan at any time. Unless sooner
terminated, the Plan shall terminate ten (10) years from the date the Plan is
adopted by the Board or approved by the shareholders of the Company, whichever
is earlier. No Stock Awards may be granted under the Plan while the Plan is
suspended or after it is terminated.
 
     (b) Rights and obligations under any Stock Award granted while the Plan is
in effect shall not be impaired by suspension or termination of the Plan, except
with the consent of the person to whom the Stock Award was granted.
 
16. EFFECTIVE DATE OF PLAN.
 
     The Plan shall become effective on the same day that the Company's initial
public offering of shares of Common Stock becomes effective, but no Stock Awards
granted under the Plan shall be exercised unless and until the Plan has been
approved by the shareholders of the Company, which approval shall be within
twelve (12) months before or after the date the Plan is adopted by the Board.
 
                                       39
<PAGE>   42
 
                                                                      1536-PS-99
<PAGE>   43



























                                     PROXY

                              ARADIGM CORPORATION

                   PROXY SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF SHAREHOLDERS
                           TO BE HELD ON MAY 21, 1999

     The undersigned hereby appoints Richard P. Thompson, Reid M. Rubsamen and
Mark A. Olbert, and each of them, as attorneys and proxies of the undersigned,
with full power of substitution, to vote all shares of stock of Aradigm
Corporation which the undersigned may be entitled to vote at the Annual Meeting
of Shareholders of Aradigm Corporation to be held at the Crowne Plaza, 1221
Chess Drive, Foster City, California on Friday, May 21, 1999 at 9:00 a.m. local
time, and at any and all postponements, continuations and adjournments thereof,
with all powers that the undersigned would possess if personally present, upon
and in respect of the following matters and in accordance with the following
instructions, with discretionary authority as to any and all other matters that
may properly come before the meeting.


                   CONTINUED AND TO BE SIGNED ON REVERSE SIDE


SEE REVERSE SIDE                                                SEE REVERSE SIDE
<PAGE>   44

ARADIGM CORPORATION
c/o EquiServe
P.O. Box 8040
Boston, MA 02266-8040


          Dear Fellow Aradigm Shareholder,

          This last year saw significant expansion of our company's development 
     programs, and of our capabilities. We entered into a major commercial 
     collaboration with Novo Nordisk, the world leader in diabetes therapy, on 
     the AERx(TM) Diabetes Management System. By year-end, both our AERx Pain 
     Management System, developed in collaboration with SmithKline Beecham and 
     the AERx Diabetes Management System were well into phase II clinical 
     testing. Aradigm believes it now has more programs in phase II testing 
     than any other similar pulmonary drug delivery company. In addition, we 
     put in place the pilot manufacturing facilities we will need to support 
     our growing clinical programs, and launch the AERx Pain Management System 
     once it is approved.

          We look forward to building upon this growing momentum in 1999 and 
     beyond.

          Very truly yours,


          /s/ Richard P. Thompson
          -------------------------------------
          Richard P. Thompson
          President and Chief Executive Officer
          Aradigm Corporation


                                  DETACH HERE
- --------------------------------------------------------------------------------
[1536 - ARADIGM CORPORATION] [FILE NAME: ARD69AELX] [VERSION - 3] [4/12/99]

<TABLE>
<CAPTION>
<S>                                                                  <C>

  [X] Please mark
      votes as in
      this example.

MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEES FOR DIRECTOR LISTED BELOW AND FOR PROPOSALS 2, 3 AND 4.

UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED FOR ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2,
3 AND 4, AS MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE
VOTED IN ACCORDANCE THEREWITH.
                                                                                                               FOR  AGAINST  ABSTAIN

1. To elect Frank N. Barker, Wayne L. Roe, Reid M. Rubsamen,         2. To approve the Company's 1996 Equity   [ ]    [ ]      [ ]
   Richard P. Thompson and Virgil D. Thompson, directors to             Incentive Plan, as amended to increase
   hold office until the next Annual Meeting of Shareholders            the aggregate number of shares of 
   and until their successors are elected.                              Common Stock authorized for issuance
                                                                        under such plan by 1,820,000 shares.

          FOR                    WITHHELD
          ALL    [ ]        [ ]  FROM ALL
       NOMINEES                  NOMINEES
                                                                                                                 
                                             MARK HERE               3. To approve the Company's Employee      FOR  AGAINST  ABSTAIN
                                           FOR ADDRESS  [ ]             Stock Purchase Plan, as amended
                                            CHANGE AND                  to increase the aggregate number       [ ]    [ ]      [ ]
                                            NOTE BELOW                  of shares of Common Stock authorized
[ ]                                                                     for issuance under such plan by
   _______________________________________                              180,000 shares.
   For all nominees except as noted above                                                                      FOR  AGAINST  ABSTAIN
                                                                     4. To ratify the selection of Ernst &
                                                                        Young LLP as independent auditors      [ ]    [ ]      [ ]
                                                                        of the Company for its fiscal year
                                                                        ending December 31, 1999.

                                                                     Please vote, date and promptly return this proxy in the 
                                                                     enclosed return envelope which is postage prepaid if mailed
                                                                     in the United States.

                                                                     Please sign exactly as your name appears hereon. If stock is
                                                                     registered in the names of two or more persons, each should
                                                                     sign. Executors, administrators, trustees, guardians and
                                                                     attorneys-in-fact should add their titles. If signer is a
                                                                     corporation, please give full corporate name and have a
                                                                     duly authorized officer sign, stating title. If signer is a 
                                                                     partnership, please sign in partnership name by authorized
                                                                     person.


Signature: _________________ Date: __________________ Signature: ___________________________________________ Date:__________________
</TABLE>


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