APPLIED ANALYTICAL INDUSTRIES INC
424B3, 1996-11-15
MEDICAL LABORATORIES
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<PAGE>   1






                                           Filed pursuant to Rule 424(b)(3)
                                       Registration Statement No. 333-05535



Prospectus Supplement No. 2, dated November 14, 1996
            (To Prospectus dated September 19, 1996,
                as supplemented on October 23, 1996)





                                   [logo] AAI


                      APPLIED ANALYTICAL INDUSTRIES, INC.


                                  Common Stock
                          (par value $0.001 per share)




     On November 14, 1996, the Company filed its Quarterly Report on Form 10-Q
for the period ended September 30, 1996 with the Securities and Exchange
Commission.  A copy of the Quarterly Report is attached.




<PAGE>   2
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                      
                                  FORM 10-Q

[X]      QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (D) OF THE
         SECURITIES EXCHANGE ACT OF 1934

FOR THE QUARTERLY PERIOD ENDED SEPTEMBER, 30, 1996

                                       OR

[  ]     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (D) OF THE
         SECURITIES EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM__________________ TO___________________

COMMISSION FILE NUMBER   0-21185


                       APPLIED ANALYTICAL INDUSTRIES, INC.

             (Exact Name of Registrant as Specified in its Charter)

                Delaware                                   04-2687849
- -----------------------------------------       --------------------------------
     (State or Other Jurisdiction of                     (I.R.S. Employer
     Incorporation or Organization)                  Identification Number)

                              5051 New Centre Drive
                        Wilmington, North Carolina 28403
                    (Address of Principal Executive Offices)
                                   (Zip Code)

                                 (910) 392-1606
              (Registrant's Telephone Number, Including Area Code)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes    X    No
                                      --------   --------

As of October 31, 1996, there were 16,286,069 shares of Applied Analytical
Industries, Inc. common stock outstanding.


<PAGE>   3



                       APPLIED ANALYTICAL INDUSTRIES, INC.

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                 PAGE NO.
                                                                                                 --------
<S>                                                                                                  <C>
PART I.           FINANCIAL INFORMATION

ITEM 1.           FINANCIAL STATEMENTS (Unaudited)
                  Condensed Consolidated Statement of Income                                         2
                  Condensed Consolidated Balance Sheet                                               3
                  Condensed Consolidated Statement of Cash Flows                                     4
                  Notes to Condensed Consolidated Financial Statements                               5

ITEM 2.           MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                  FINANCIAL CONDITION AND RESULTS OF OPERATIONS                                      6

PART II.          OTHER INFORMATION
                  Any item which is not applicable or to which the answer is
                  negative has been omitted.

ITEM 6.           EXHIBITS AND REPORTS ON FORM 8-K                                                   9

SIGNATURES                                                                                           9
</TABLE>



                                        1

<PAGE>   4

                                       
                      APPLIED ANALYTICAL INDUSTRIES, INC.

                   CONDENSED CONSOLIDATED STATEMENT OF INCOME
                      (In thousands, except per share data)
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                        THREE MONTHS ENDED                NINE MONTHS ENDED
                                                                           SEPTEMBER 30,                    SEPTEMBER 30,
                                                                    ----------------------------       -------------------------
                                                                       1996             1995              1996          1995
                                                                    -----------       ----------       -----------   -----------
<S>                                                               <C>               <C>              <C>           <C>         
Net sales (includes related party net sales 
     of $2,608, $2,732, $7,575 and $5,802 for 
     the three months ended September 30, 1996 and
     1995 and the nine months ended September 30,
     1996 and 1995, respectively)                                 $     10,396      $     8,932      $     31,170  $     25,533

Operating costs and expenses:
     Cost of sales                                                       4,194            3,476            13,010        10,746
     Selling                                                             1,448            1,305             4,575         3,655
     General and administrative                                          2,016            1,959             6,672         5,951
     Research and development                                            1,398              939             3,189         2,294
                                                                  ------------      -----------      ------------  ------------ 
                                                                         9,056            7,679            27,446        22,646
                                                                  ------------      -----------      ------------  ------------ 
Income from operations:                                                  1,340            1,253             3,724         2,887
                                                                  ------------      -----------      ------------  ------------ 
Other income (expense)
     Interest                                                             (113)            (266)             (353)         (742)
     Other                                                                  73               46               292           118
                                                                  ------------      -----------      ------------  ------------ 
                                                                           (40)            (220)              (61)         (624)
                                                                  ------------      -----------      ------------  ------------ 
Income before income taxes                                               1,300            1,033             3,663         2,263
Provision for income taxes                                                 501             --               1,468         --
                                                                  ------------      -----------      ------------  ------------ 
                                                                  
Income after income taxes                                                  799            1,033             2,195         2,263
Equity income (loss)                                                     --                  55             --             (359)
                                                                  ------------      -----------      ------------  ------------ 
Net income                                                        $        799      $     1,088      $      2,195  $      1,904
                                                                  ============      ===========      ============  ============ 

Earnings per share                                                $       0.06                       $       0.18
                                                                  ============                       ============
Weighted average shares outstanding                                     13,484                             12,444
                                                                  ============                       ============

Pro forma data (unaudited):
    Net income, as reported                                                         $     1,088                    $      1,904
    Pro forma income taxes                                                                  433                             937
                                                                                    ===========                    ============
    Pro forma net income                                                            $       655                    $        967
                                                                                    ===========                    ============
Pro forma earnings per share                                                        $      0.05                    $       0.08
                                                                                    ===========                    ============
Weighted average shares outstanding                                                      11,918                          11,918
                                                                                    ===========                    ============
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       2


<PAGE>   5

                       APPLIED ANALYTICAL INDUSTRIES, INC.

                      CONDENSED CONSOLIDATED BALANCE SHEET
                                 (In thousands)

<TABLE>
<CAPTION>
                                                                SEPTEMBER 30,      DECEMBER 31,
                                                                     1996              1995
                                                                -------------      -------------
                                                                 (Unaudited)
                                     ASSETS
<S>                                                            <C>                <C>          
Current assets:
    Cash and cash equivalents                                  $      47,838      $      13,081
    Accounts receivable:
        Trade and other                                                8,922              7,302
        Related parties                                                1,550                 73
    Work-in-progress                                                   2,960              4,134
    Prepaid and other current assets                                   3,334              1,238
                                                               -------------      -------------
                Total current assets                                  64,604             25,828
                                                               -------------      -------------

Property and equipment                                                25,206             20,139
    Less:  accumulated depreciation                                  (10,682)            (9,235)
                                                               -------------      -------------
                                                                      14,524             10,904
Other assets                                                           2,374              2,424
                                                               -------------      -------------
                Total assets                                   $      81,502      $      39,156
                                                               =============      =============

                      LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
    Revolving and other current loan obligations               $       1,525      $       4,081
    Current maturities of long-term debt                                 645                645
    Accounts payable and other accrued liabilities                     5,955              5,751
    Customer advances                                                    795              1,677
    Dividends payable                                                    ---              1,300
                                                               -------------      -------------
                Total current liabilities                              8,920             13,454
Long-term debt and other liabilities                                   3,266              3,712
                                                               -------------      -------------
                Total liabilities                                     12,186             17,166
                                                               -------------      -------------

Stockholders' equity:
    Preferred stock                                                      ---               ---
    Common stock                                                          16                321
    Additional paid-in-capital                                        67,383             21,510
    Retained earnings                                                  2,747                552
                                                               -------------      -------------
                                                                      70,146             22,383
    Treasury stock and other reductions                                 (830)              (393)
                                                               -------------      -------------
                Total stockholders' equity                            69,316             21,990
                                                               -------------      -------------
                Total liabilities and stockholders' equity     $      81,502      $      39,156
                                                               =============      =============
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       3


<PAGE>   6

                       APPLIED ANALYTICAL INDUSTRIES, INC.

                 CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS
                                 (In thousands)

<TABLE>
<CAPTION>
                                                                                   NINE MONTHS ENDED
                                                                                     SEPTEMBER 30,
                                                                         -----------------------------------
                                                                               1996               1995    
                                                                         --------------       --------------
                                                                                      (Unaudited)
<S>                                                                      <C>                  <C>            
Cash flows from operating activities:
   Net income                                                            $         2,195      $         1,904
   Adjustments to reconcile net income to net cash
       provided (used) by operating activities:
       Depreciation and amortization                                               1,475                1,168
       Equity (income) loss                                                        ---                    359
       Other, net                                                                     39                    5
       Changes in assets and liabilities:
           Trade and other receivables                                            (3,097)              (1,257)
           Other, net                                                             (1,616)              (1,072)

                                                                         ---------------      ---------------
Net cash provided (used) by operating activities                                  (1,004)               1,107
                                                                         ---------------      ---------------

Cash flows from investing activities:
    Purchase of property and equipment                                            (5,070)              (1,061)
    Other, net                                                                        55               (1,707)

                                                                         ---------------      ---------------
Net cash used by investing activities                                             (5,015)              (2,768)
                                                                         ---------------      ---------------

Cash flows from financing activities:
    Net (payments) proceeds on line of credit                                     (2,556)               1,961
    Net (payments) proceeds from long-term borrowings                               (446)               1,071
    Net proceeds from sale of common stock                                        44,829                ---
    Dividends                                                                     (1,051)              (1,761)

                                                                         ---------------      ---------------
Net cash provided (used) by financing activities                                  40,776                1,271
                                                                         ---------------      ---------------

Net increase (decrease) in cash                                                   34,757                 (390)
Cash and cash equivalents, beginning of period                                    13,081                  473
                                                                         ---------------      ---------------
Cash and cash equivalents, end of period                                 $        47,838      $            83
                                                                         ===============      ===============

Supplemental information - cash paid for:
      Interest                                                           $           359      $           213
      Income taxes                                                       $         1,393      $         ---
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       4


<PAGE>   7

                       APPLIED ANALYTICAL INDUSTRIES, INC.

              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS


1.       Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been
prepared in accordance with generally accepted accounting principles and
applicable Securities and Exchange Commission regulations for interim financial
information. These financial statements do not include all of the information
and footnotes required by generally accepted accounting principles for complete
financial statements. It is presumed that users of this interim financial
information have read or have access to the audited financial statements for the
preceding fiscal year. In the opinion of management, all adjustments (consisting
of normal recurring adjustments) considered necessary for fair presentation have
been included. Operating results for the interim periods presented are not
necessarily indicative of the results that may be expected for the full year.

Pro forma financial information is presented on the condensed consolidated
statement of income to reflect a pro forma income tax provision for 1995. Prior
to November 17, 1995, the Company was treated as an S Corporation for income tax
purposes and was not subject to federal and state income taxes. The pro forma
income tax provision applies federal and state income tax rates that would have
resulted if the Company had been subject to corporate income taxes from the
beginning of the year.

2.       Stockholders' Equity

On September 19, 1996, the Company completed an initial public offering ("IPO")
of 3,105,000 shares of Common Stock at $16.00 per share. The net proceeds of the
IPO, after underwriting discount and costs in connection with the sale and
distribution of the securities, were approximately $45 million. Concurrent with
the closing of the IPO, all outstanding shares of the Company's Series A
convertible preferred stock and Class B non-voting common stock were converted
into shares of the Company's voting common stock, $.001 par value per share.

The Company recorded unearned compensation of approximately $490 thousand as a
reduction to stockholder's equity for a March 1996 award under the Company's
1995 Restricted Stock Award Plan. As of September 30, 1996, approximately $53
thousand of such amount has been expensed. The remaining amount will be
recognized over the two-year vesting period following the IPO.

3.       Earnings Per Share

The weighted average shares outstanding used in the calculation of earnings per
share and pro forma earnings per share include the effect of the conversion of
convertible preferred stock and Class B common stock described above as if they
were converted as of January 1, 1995. Additionally, common stock or equivalent
shares from stock options and awards sold or issued at prices below the IPO
price per share in the twelve months preceding the initial filing have been
included in the calculation as if outstanding as of January 1, 1995.


                                        5

<PAGE>   8



ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
         CONDITION AND RESULTS OF OPERATIONS


RESULTS OF OPERATIONS

Quarter ended September 30,1996 compared to quarter ended September 30, 1995

Net sales for the third quarter of 1996 increased to $10.4 million compared to
$8.9 million in the third quarter of 1995. Revenues from fee-for-service
business increased 23% to $10.1 million from $8.2 million in the corresponding
quarter of 1995. License revenues for the third quarter of 1996 were $312
thousand as compared to $738 thousand for the third quarter of 1995. All of the
Company's license revenues for the first nine months of 1995 occurred in the
third quarter of 1995.

Costs of sales for the third quarter of 1996 increased as a percent of net sales
to 40.3% from 38.9% during the comparable period of 1995. This increase is
primarily attributable to the impact of the fluctuation in license revenues. The
Company has experienced no significant increases in the components of costs of
sales as a percentage of net sales. Excluding license revenues from net sales,
the cost of sales percentage declined slightly in 1996 compared to 1995.

Selling expense for the third quarter of 1996 increased by 11% to $1.4 million
from $1.3 million in the third quarter of 1995; however, it decreased as a
percent of net sales to 13.9% compared to 14.6% in 1995. The increase in selling
expense is primarily attributable to marketing expansions to the West Coast of
the United States and Europe.

General and administrative expense for the third quarter of 1996 increased by 3%
but decreased as a percent of net sales to 19.4% compared to 21.9% in 1995.
General and administrative expenses have been in-line with expectations and the
Company has continued its effort to control these costs.

Research and development costs for the third quarter of 1996 increased by 49% to
$1.4 million from $0.9 million in the third quarter of 1995. This increased
spending as a percentage of net sales to 13.4% compared to 10.5% in 1995. The
increase in research and development costs reflects an increase in the number of
active projects in 1996 compared to those under development in 1995.

Interest expense declined in 1996 compared to 1995 as a result of reduced
borrowings.

Net income for the third quarter of 1996 increased 22% compared to pro forma net
income for the third quarter of 1995. The increase in net income is primarily
attributable to the increase in net sales.


Nine months ended September 30, 1996 compared to nine months ended September 30,
1995

Net sales for the nine months ended September 30, 1996 increased to $31.2
million compared to $25.5 million in the corresponding period of 1995. Revenues
from fee-for-service business increased 21% to $29.9 million compared to $24.8
million in 1995. License revenues increased 69% to $1.2 million compared to $0.7
million in 1995.

                                        6

<PAGE>   9





Costs of sales for the first nine months of 1996 declined slightly as a percent
of net sales to 41.7% from 42.1% in the comparable period of 1995. The Company
has experienced no significant increases in the components of costs of sales as
a percentage of net sales.

Selling expense for the first nine months of 1996 increased by 25% to $4.6
million from $3.7 million in the corresponding period of 1995 and increased as a
percent of net sales to 14.7% compared to 14.3% in 1995. The increase in
selling expense is primarily attributable to marketing expansions to the 
West Coast of the United States and Europe.

General and administrative expense for the first nine months of 1996 increased
by 12% to $6.7 million from $6.0 million in the corresponding period of 1995;
however, it decreased as a percent of net sales to 21.4% compared to 23.3% in
1995.  The decrease as a percent of net sales is a reflection of the
Company's continued effort to control general and administrative costs.

Research and development costs for the first nine months of 1996 increased by
39% to $3.2 million from $2.3 million in the corresponding period of 1995. This
increased spending to 10.2% of net sales compared to 9.0% of net sales in 1995.
The increase in research and development costs reflects an increase in the
number of active projects in 1996 compared to those under development in 1995.

Interest expense declined in 1996 compared to 1995 as a result of reduced
borrowings.

Net income for the first nine months of 1996 increased 127% compared to pro
forma net income for the corresponding period of 1995. The increase in net
income is primarily attributable to the increase in net sales in 1996 and not
recognizing any loss on its equity investment in Endeavor. During the nine
months ended September 30,1995, the Company recognized a net loss of $359
thousand from its equity investment in Endeavor.


Quarterly Results

The Company's quarterly results have been, and are expected to continue to be,
subject to fluctuations. Quarterly results can fluctuate as a result of a number
of factors, including the commencement, completion or cancellation of large
contracts, progress of ongoing contracts, recognition of licensing revenue,
potential acquisitions, the timing of start-up expenses for new facilities and
changes in the mix of services. Since a large percentage of the Company's
operating costs are relatively fixed, variations in the timing and progress of
large contracts or the recognition of licensing revenue (on projects for which
associated expense may have been recognized in prior periods) can materially
affect quarterly results. The Company believes that comparisons of its quarterly
financial results are not necessarily meaningful and should not be relied upon
as an indication of future performance.



                                        7

<PAGE>   10



LIQUIDITY AND CAPITAL RESOURCES

The Company has funded its business through operating cash flows, proceeds from
borrowings and the issuance of equity. On September 19, 1996, the Company
completed an IPO of common stock with net proceeds to the Company of
approximately $45 million. Working capital at September 30, 1996 was
approximately $55.7 million compared to $12.4 million at December 31, 1995. The
increase is primarily attributable to the IPO proceeds.

Capital expenditures for the first nine months of 1996 were $5.1 million
compared to $1.1 million for the corresponding period of 1995. The increase in
1996 is primarily attributable to the expansion of clinical supply manufacturing
facilities and formulation development facilities, and additional scientific
instrumentation acquired to expand the capacity of laboratory operations.

In May 1996, the Company acquired an option to purchase the outstanding stock of
a European contract research and development organization. The Company paid
approximately $1.0 million to acquire such option, which amount is held in
escrow and will be applied to the purchase price if the Company elects to
exercise such option or returned to the Company if, prior to the expiration of
the option, certain substantial conditions are not satisfied. The Company is
currently conducting its due diligence review and, at this time, does not have
sufficient information to determine if this option will be exercised.  The
option terminates on November 28, 1996.

The Company expects to continue expanding its operations through internal growth
and strategic acquisitions. The Company expects such activities will be funded
from existing cash and cash equivalents, cash flow from operations and
borrowings under its credit line. The Company believes that such sources of cash
will be sufficient to fund operations for the foreseeable future and to pay
existing debt and other capital obligations as they become due. Although the
Company has no present acquisition agreements or arrangements other than
described above, there may be acquisition or other growth opportunities that
require additional external financing, and the Company may from time to time
seek to obtain funds from public or private issuances of equity or debt
securities. There can be no assurances that such financings will be available on
terms acceptable to the Company.



                                        8

<PAGE>   11



PART II  OTHER INFORMATION

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

         (a)      Exhibits

                  A list of the exhibits required to be filed as part of this
                  Report on Form 10-Q is set forth in the "Exhibit Index", which
                  immediately precedes such exhibits, and is incorporated herein
                  by reference.

         (b)      Reports on Form 8-K  (Not Applicable)




SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                            APPLIED ANALYTICAL INDUSTRIES, INC.

Date:  November 14, 1996    By:    /s/ R. Forrest Waldon
                                   --------------------------------------------
                                   R. Forrest Waldon
                                   Vice President and Secretary
                                   (Duly Authorized Officer)

Date:  November 14, 1996    By:    /s/ Mark P. Colonnese
                                   --------------------------------------------
                                   Mark P. Colonnese
                                   Vice President and Chief Financial Officer
                                   (Principal Financial and Accounting Officer)



                                        9

<PAGE>   12
 
                                 EXHIBIT INDEX
 
<TABLE>
<CAPTION>
EXHIBIT                                                                               
  NO.                                     DESCRIPTION                        
- ------          --------------------------------------------------------------------- 
<C>        <C>  <S>                                                                   
  3.1        -- Amended and Restated Certificate of Incorporation of the Company
  3.2        -- Restated By-laws of the Company (incorporated by reference to 
                Exhibit 3.2 to the Company's Registration Statement on Form S-1 
                (Registration Statement No. 333-05535))
  4.1        -- Articles Fourth, Seventh, Eleventh and Twelfth of the Amended
                and Restated Certificate of Incorporation of the Company (included in
                Exhibit 3.1)
  4.2        -- Article II of the Restated By-laws of the Company (included
                in Exhibit 3.2)
  4.3        -- Specimen Certificate for shares of Common Stock, $.001 par value, of
                the Company (incorporated by reference to Exhibit 4.3
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.1        -- Employment Agreement dated November 17, 1995 between the Company and
                Frederick D. Sancilio (incorporated by reference to Exhibit 10.1
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.2        -- Applied Analytical Industries, Inc. 1995 Restricted Stock Award Plan 
                (incorporated by reference to Exhibit 10.2 to the Company's Registration 
                Statement on Form S-1 (Registration No. 333-05535))       
 10.3        -- Applied Analytical Industries, Inc. 1995 Stock Option Plan (incorporated 
                by reference to Exhibit 10.3 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.4        -- Applied Analytical Industries, Inc. 1996 Stock Option Plan (incorporated 
                by reference to Exhibit 10.4 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.5        -- Stockholder Agreement dated as of November 17, 1995 among the
                Company, GS Capital Partners II, L.P., GS Capital Partners II
                Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street
                Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley Partners
                III, L.P., Wakefield Group Limited Partnership, James L. Waters,
                Frederick D. Sancilio and the parties listed on Schedule 1 thereto 
                (incorporated by reference to Exhibit 10.5 to the Company's Registration 
                Statement on Form S-1 (Registration No. 333-05535))       
 10.6        -- Preferred Stock Purchase Agreement dated as of November 17, 1995
                among the Company, GS Capital Partners II, L.P., GS Capital Partners
                II Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone
                Street Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley
                Partners III, L.P., Wakefield Group Limited Partnership and James L.
                Waters (incorporated by reference to Exhibit 10.6 to the Company's 
                Registration Statement on Form S-1 (Registration No. 333-05535))       
 10.7        -- Loan Agreement dated as of December 21, 1992 between NationsBank, N.A.
                and the Company, together with the First Amendment and Second Amendment 
                thereto and agreement extending the term thereof (incorporated by 
                reference to Exhibit 10.7 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.8        -- Loan Agreement dated as of November 1, 1988 between the Company and
                The New Hanover County Industrial Facilities and Pollution Control
                Financing Authority (incorporated by reference to Exhibit 10.8
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.9        -- Letter of Credit Reimbursement Agreement dated November 1, 1988
                between NationsBank, N.A. and the Company (incorporated by 
                reference to Exhibit 10.9 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.10       -- Lease Agreement dated as of March 7, 1994 between 5051 New Centre
                Drive, L.L.C., as landlord, and the Company, as tenant (incorporated 
                by reference to Exhibit 10.10 to the Company's Registration Statement 
                on Form S-1 (Registration No. 333-05535))       
 10.11       -- Lease Agreement dated as of December 23, 1993 between I-40
                Properties, as landlord, and the Company, as tenant (incorporated by 
                reference to Exhibit 10.11 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.12       -- Development Agreement dated as of April 25, 1994 between the Company
                and Endeavor Pharmaceuticals, Inc. (f/n/a GenerEst, Inc.) 
                (incorporated by reference to Exhibit 10.12 to the Company's 
                Registration Statement on Form S-1 (Registration No. 333-05535))       
 10.13       -- Development Agreement dated as of April 4, 1995 between the Company
                and Aesgen, Inc. (incorporated by reference to Exhibit 10.13
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.14*      -- Option Agreement dated May 28, 1996 with respect to an option granted
                to the Company to acquire a certain European contract research and
                development organization (incorporated by reference to Exhibit 10.14
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
</TABLE>

<PAGE>   13
 
<TABLE>
<CAPTION>
EXHIBIT                                                                               
  NO.                                     DESCRIPTION                        
- ------          --------------------------------------------------------------------- 
<C>        <C>  <S>                                                                   
 10.15       -- Letter dated August 22, 1996 from NationsBank, N.A. to the Company
                extending the maturity of certain indebtedness (incorporated by 
                reference to Exhibit 10.15 to the Company's Registration Statement 
                on Form S-1 (Registration No. 333-05535))       
 10.16       -- Registration Rights Agreement dated as of November 17, 1996 among the 
                Company, GS Capital Partners II, L.P., GS Capital Partners II 
                Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street 
                Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley 
                Partners III, L.P., Wakefield Group Limited Partnership, James L. Waters, 
                Frederick D. Sancilio and the parties listed on Schedule 1 thereto 
                (incorporated by reference to Exhibit 10.16 to Post-effective
                Amendment No. 1 to the Company's Registration Statement on Form S-1 
                (Registration No. 333-05535))       
 10.17       -- Underwriting Agreement dated September 19, 1996 between the Company and 
                Goldman, Sachs & Co., Cowen & Company and Lehman Brothers, Inc., as 
                representatives of the underwriters listed on Schedule 1 thereto
 27          -- Financial Data Schedule (for SEC use only)
</TABLE>
 
- ---------------
 
  * Certain information has been omitted from this exhibit pursuant to a request
    for confidential treatment granted by the Securities and Exchange
    Commission on September 18, 1996.


                            [EXHIBITS NOT ATTACHED]


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