APPLIED ANALYTICAL INDUSTRIES INC
10-Q, 1996-11-14
MEDICAL LABORATORIES
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<PAGE>   1
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                      
                                  FORM 10-Q

[X]      QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (D) OF THE
         SECURITIES EXCHANGE ACT OF 1934

FOR THE QUARTERLY PERIOD ENDED SEPTEMBER, 30, 1996

                                       OR

[  ]     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (D) OF THE
         SECURITIES EXCHANGE ACT OF 1934

FOR THE TRANSITION PERIOD FROM__________________ TO___________________

COMMISSION FILE NUMBER   0-21185


                       APPLIED ANALYTICAL INDUSTRIES, INC.

             (Exact Name of Registrant as Specified in its Charter)

                Delaware                                   04-2687849
- -----------------------------------------       --------------------------------
     (State or Other Jurisdiction of                     (I.R.S. Employer
     Incorporation or Organization)                  Identification Number)

                              5051 New Centre Drive
                        Wilmington, North Carolina 28403
                    (Address of Principal Executive Offices)
                                   (Zip Code)

                                 (910) 392-1606
              (Registrant's Telephone Number, Including Area Code)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes    X    No
                                      --------   --------

As of October 31, 1996, there were 16,286,069 shares of Applied Analytical
Industries, Inc. common stock outstanding.


<PAGE>   2



                       APPLIED ANALYTICAL INDUSTRIES, INC.

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                 PAGE NO.
                                                                                                 --------
<S>                                                                                                  <C>
PART I.           FINANCIAL INFORMATION

ITEM 1.           FINANCIAL STATEMENTS (Unaudited)
                  Condensed Consolidated Statement of Income                                         2
                  Condensed Consolidated Balance Sheet                                               3
                  Condensed Consolidated Statement of Cash Flows                                     4
                  Notes to Condensed Consolidated Financial Statements                               5

ITEM 2.           MANAGEMENT'S DISCUSSION AND ANALYSIS OF
                  FINANCIAL CONDITION AND RESULTS OF OPERATIONS                                      6

PART II.          OTHER INFORMATION
                  Any item which is not applicable or to which the answer is
                  negative has been omitted.

ITEM 6.           EXHIBITS AND REPORTS ON FORM 8-K                                                   9

SIGNATURES                                                                                           9
</TABLE>



                                        1

<PAGE>   3

                                       
                      APPLIED ANALYTICAL INDUSTRIES, INC.

                   CONDENSED CONSOLIDATED STATEMENT OF INCOME
                      (In thousands, except per share data)
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                        THREE MONTHS ENDED                NINE MONTHS ENDED
                                                                           SEPTEMBER 30,                    SEPTEMBER 30,
                                                                    ----------------------------       -------------------------
                                                                       1996             1995              1996          1995
                                                                    -----------       ----------       -----------   -----------
<S>                                                               <C>               <C>              <C>           <C>         
Net sales (includes related party net sales 
     of $2,608, $2,732, $7,575 and $5,802 for 
     the three months ended September 30, 1996 and
     1995 and the nine months ended September 30,
     1996 and 1995, respectively)                                 $     10,396      $     8,932      $     31,170  $     25,533

Operating costs and expenses:
     Cost of sales                                                       4,194            3,476            13,010        10,746
     Selling                                                             1,448            1,305             4,575         3,655
     General and administrative                                          2,016            1,959             6,672         5,951
     Research and development                                            1,398              939             3,189         2,294
                                                                  ------------      -----------      ------------  ------------ 
                                                                         9,056            7,679            27,446        22,646
                                                                  ------------      -----------      ------------  ------------ 
Income from operations:                                                  1,340            1,253             3,724         2,887
                                                                  ------------      -----------      ------------  ------------ 
Other income (expense)
     Interest                                                             (113)            (266)             (353)         (742)
     Other                                                                  73               46               292           118
                                                                  ------------      -----------      ------------  ------------ 
                                                                           (40)            (220)              (61)         (624)
                                                                  ------------      -----------      ------------  ------------ 
Income before income taxes                                               1,300            1,033             3,663         2,263
Provision for income taxes                                                 501             --               1,468         --
                                                                  ------------      -----------      ------------  ------------ 
                                                                  
Income after income taxes                                                  799            1,033             2,195         2,263
Equity income (loss)                                                     --                  55             --             (359)
                                                                  ------------      -----------      ------------  ------------ 
Net income                                                        $        799      $     1,088      $      2,195  $      1,904
                                                                  ============      ===========      ============  ============ 

Earnings per share                                                $       0.06                       $       0.18
                                                                  ============                       ============
Weighted average shares outstanding                                     13,484                             12,444
                                                                  ============                       ============

Pro forma data (unaudited):
    Net income, as reported                                                         $     1,088                    $      1,904
    Pro forma income taxes                                                                  433                             937
                                                                                    ===========                    ============
    Pro forma net income                                                            $       655                    $        967
                                                                                    ===========                    ============
Pro forma earnings per share                                                        $      0.05                    $       0.08
                                                                                    ===========                    ============
Weighted average shares outstanding                                                      11,918                          11,918
                                                                                    ===========                    ============
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       2


<PAGE>   4

                       APPLIED ANALYTICAL INDUSTRIES, INC.

                      CONDENSED CONSOLIDATED BALANCE SHEET
                                 (In thousands)

<TABLE>
<CAPTION>
                                                                SEPTEMBER 30,      DECEMBER 31,
                                                                     1996              1995
                                                                -------------      -------------
                                                                 (Unaudited)
                                     ASSETS
<S>                                                            <C>                <C>          
Current assets:
    Cash and cash equivalents                                  $      47,838      $      13,081
    Accounts receivable:
        Trade and other                                                8,922              7,302
        Related parties                                                1,550                 73
    Work-in-progress                                                   2,960              4,134
    Prepaid and other current assets                                   3,334              1,238
                                                               -------------      -------------
                Total current assets                                  64,604             25,828
                                                               -------------      -------------

Property and equipment                                                25,206             20,139
    Less:  accumulated depreciation                                  (10,682)            (9,235)
                                                               -------------      -------------
                                                                      14,524             10,904
Other assets                                                           2,374              2,424
                                                               -------------      -------------
                Total assets                                   $      81,502      $      39,156
                                                               =============      =============

                      LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
    Revolving and other current loan obligations               $       1,525      $       4,081
    Current maturities of long-term debt                                 645                645
    Accounts payable and other accrued liabilities                     5,955              5,751
    Customer advances                                                    795              1,677
    Dividends payable                                                    ---              1,300
                                                               -------------      -------------
                Total current liabilities                              8,920             13,454
Long-term debt and other liabilities                                   3,266              3,712
                                                               -------------      -------------
                Total liabilities                                     12,186             17,166
                                                               -------------      -------------

Stockholders' equity:
    Preferred stock                                                      ---               ---
    Common stock                                                          16                321
    Additional paid-in-capital                                        67,383             21,510
    Retained earnings                                                  2,747                552
                                                               -------------      -------------
                                                                      70,146             22,383
    Treasury stock and other reductions                                 (830)              (393)
                                                               -------------      -------------
                Total stockholders' equity                            69,316             21,990
                                                               -------------      -------------
                Total liabilities and stockholders' equity     $      81,502      $      39,156
                                                               =============      =============
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       3


<PAGE>   5

                       APPLIED ANALYTICAL INDUSTRIES, INC.

                 CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS
                                 (In thousands)

<TABLE>
<CAPTION>
                                                                                   NINE MONTHS ENDED
                                                                                     SEPTEMBER 30,
                                                                         -----------------------------------
                                                                               1996               1995    
                                                                         --------------       --------------
                                                                                      (Unaudited)
<S>                                                                      <C>                  <C>            
Cash flows from operating activities:
   Net income                                                            $         2,195      $         1,904
   Adjustments to reconcile net income to net cash
       provided (used) by operating activities:
       Depreciation and amortization                                               1,475                1,168
       Equity (income) loss                                                        ---                    359
       Other, net                                                                     39                    5
       Changes in assets and liabilities:
           Trade and other receivables                                            (3,097)              (1,257)
           Other, net                                                             (1,616)              (1,072)

                                                                         ---------------      ---------------
Net cash provided (used) by operating activities                                  (1,004)               1,107
                                                                         ---------------      ---------------

Cash flows from investing activities:
    Purchase of property and equipment                                            (5,070)              (1,061)
    Other, net                                                                        55               (1,707)

                                                                         ---------------      ---------------
Net cash used by investing activities                                             (5,015)              (2,768)
                                                                         ---------------      ---------------

Cash flows from financing activities:
    Net (payments) proceeds on line of credit                                     (2,556)               1,961
    Net (payments) proceeds from long-term borrowings                               (446)               1,071
    Net proceeds from sale of common stock                                        44,829                ---
    Dividends                                                                     (1,051)              (1,761)

                                                                         ---------------      ---------------
Net cash provided (used) by financing activities                                  40,776                1,271
                                                                         ---------------      ---------------

Net increase (decrease) in cash                                                   34,757                 (390)
Cash and cash equivalents, beginning of period                                    13,081                  473
                                                                         ---------------      ---------------
Cash and cash equivalents, end of period                                 $        47,838      $            83
                                                                         ===============      ===============

Supplemental information - cash paid for:
      Interest                                                           $           359      $           213
      Income taxes                                                       $         1,393      $         ---
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       4


<PAGE>   6

                       APPLIED ANALYTICAL INDUSTRIES, INC.

              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS


1.       Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been
prepared in accordance with generally accepted accounting principles and
applicable Securities and Exchange Commission regulations for interim financial
information. These financial statements do not include all of the information
and footnotes required by generally accepted accounting principles for complete
financial statements. It is presumed that users of this interim financial
information have read or have access to the audited financial statements for the
preceding fiscal year. In the opinion of management, all adjustments (consisting
of normal recurring adjustments) considered necessary for fair presentation have
been included. Operating results for the interim periods presented are not
necessarily indicative of the results that may be expected for the full year.

Pro forma financial information is presented on the condensed consolidated
statement of income to reflect a pro forma income tax provision for 1995. Prior
to November 17, 1995, the Company was treated as an S Corporation for income tax
purposes and was not subject to federal and state income taxes. The pro forma
income tax provision applies federal and state income tax rates that would have
resulted if the Company had been subject to corporate income taxes from the
beginning of the year.

2.       Stockholders' Equity

On September 19, 1996, the Company completed an initial public offering ("IPO")
of 3,105,000 shares of Common Stock at $16.00 per share. The net proceeds of the
IPO, after underwriting discount and costs in connection with the sale and
distribution of the securities, were approximately $45 million. Concurrent with
the closing of the IPO, all outstanding shares of the Company's Series A
convertible preferred stock and Class B non-voting common stock were converted
into shares of the Company's voting common stock, $.001 par value per share.

The Company recorded unearned compensation of approximately $490 thousand as a
reduction to stockholder's equity for a March 1996 award under the Company's
1995 Restricted Stock Award Plan. As of September 30, 1996, approximately $53
thousand of such amount has been expensed. The remaining amount will be
recognized over the two-year vesting period following the IPO.

3.       Earnings Per Share

The weighted average shares outstanding used in the calculation of earnings per
share and pro forma earnings per share include the effect of the conversion of
convertible preferred stock and Class B common stock described above as if they
were converted as of January 1, 1995. Additionally, common stock or equivalent
shares from stock options and awards sold or issued at prices below the IPO
price per share in the twelve months preceding the initial filing have been
included in the calculation as if outstanding as of January 1, 1995.


                                        5

<PAGE>   7



ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
         CONDITION AND RESULTS OF OPERATIONS


RESULTS OF OPERATIONS

Quarter ended September 30,1996 compared to quarter ended September 30, 1995

Net sales for the third quarter of 1996 increased to $10.4 million compared to
$8.9 million in the third quarter of 1995. Revenues from fee-for-service
business increased 23% to $10.1 million from $8.2 million in the corresponding
quarter of 1995. License revenues for the third quarter of 1996 were $312
thousand as compared to $738 thousand for the third quarter of 1995. All of the
Company's license revenues for the first nine months of 1995 occurred in the
third quarter of 1995.

Costs of sales for the third quarter of 1996 increased as a percent of net sales
to 40.3% from 38.9% during the comparable period of 1995. This increase is
primarily attributable to the impact of the fluctuation in license revenues. The
Company has experienced no significant increases in the components of costs of
sales as a percentage of net sales. Excluding license revenues from net sales,
the cost of sales percentage declined slightly in 1996 compared to 1995.

Selling expense for the third quarter of 1996 increased by 11% to $1.4 million
from $1.3 million in the third quarter of 1995; however, it decreased as a
percent of net sales to 13.9% compared to 14.6% in 1995. The increase in selling
expense is primarily attributable to marketing expansions to the West Coast of
the United States and Europe.

General and administrative expense for the third quarter of 1996 increased by 3%
but decreased as a percent of net sales to 19.4% compared to 21.9% in 1995.
General and administrative expenses have been in-line with expectations and the
Company has continued its effort to control these costs.

Research and development costs for the third quarter of 1996 increased by 49% to
$1.4 million from $0.9 million in the third quarter of 1995. This increased
spending as a percentage of net sales to 13.4% compared to 10.5% in 1995. The
increase in research and development costs reflects an increase in the number of
active projects in 1996 compared to those under development in 1995.

Interest expense declined in 1996 compared to 1995 as a result of reduced
borrowings.

Net income for the third quarter of 1996 increased 22% compared to pro forma net
income for the third quarter of 1995. The increase in net income is primarily
attributable to the increase in net sales.


Nine months ended September 30, 1996 compared to nine months ended September 30,
1995

Net sales for the nine months ended September 30, 1996 increased to $31.2
million compared to $25.5 million in the corresponding period of 1995. Revenues
from fee-for-service business increased 21% to $29.9 million compared to $24.8
million in 1995. License revenues increased 69% to $1.2 million compared to $0.7
million in 1995.

                                        6

<PAGE>   8





Costs of sales for the first nine months of 1996 declined slightly as a percent
of net sales to 41.7% from 42.1% in the comparable period of 1995. The Company
has experienced no significant increases in the components of costs of sales as
a percentage of net sales.

Selling expense for the first nine months of 1996 increased by 25% to $4.6
million from $3.7 million in the corresponding period of 1995 and increased as a
percent of net sales to 14.7% compared to 14.3% in 1995. The increase in
selling expense is primarily attributable to marketing expansions to the 
West Coast of the United States and Europe.

General and administrative expense for the first nine months of 1996 increased
by 12% to $6.7 million from $6.0 million in the corresponding period of 1995;
however, it decreased as a percent of net sales to 21.4% compared to 23.3% in
1995.  The decrease as a percent of net sales is a reflection of the
Company's continued effort to control general and administrative costs.

Research and development costs for the first nine months of 1996 increased by
39% to $3.2 million from $2.3 million in the corresponding period of 1995. This
increased spending to 10.2% of net sales compared to 9.0% of net sales in 1995.
The increase in research and development costs reflects an increase in the
number of active projects in 1996 compared to those under development in 1995.

Interest expense declined in 1996 compared to 1995 as a result of reduced
borrowings.

Net income for the first nine months of 1996 increased 127% compared to pro
forma net income for the corresponding period of 1995. The increase in net
income is primarily attributable to the increase in net sales in 1996 and not
recognizing any loss on its equity investment in Endeavor. During the nine
months ended September 30,1995, the Company recognized a net loss of $359
thousand from its equity investment in Endeavor.


Quarterly Results

The Company's quarterly results have been, and are expected to continue to be,
subject to fluctuations. Quarterly results can fluctuate as a result of a number
of factors, including the commencement, completion or cancellation of large
contracts, progress of ongoing contracts, recognition of licensing revenue,
potential acquisitions, the timing of start-up expenses for new facilities and
changes in the mix of services. Since a large percentage of the Company's
operating costs are relatively fixed, variations in the timing and progress of
large contracts or the recognition of licensing revenue (on projects for which
associated expense may have been recognized in prior periods) can materially
affect quarterly results. The Company believes that comparisons of its quarterly
financial results are not necessarily meaningful and should not be relied upon
as an indication of future performance.



                                        7

<PAGE>   9



LIQUIDITY AND CAPITAL RESOURCES

The Company has funded its business through operating cash flows, proceeds from
borrowings and the issuance of equity. On September 19, 1996, the Company
completed an IPO of common stock with net proceeds to the Company of
approximately $45 million. Working capital at September 30, 1996 was
approximately $55.7 million compared to $12.4 million at December 31, 1995. The
increase is primarily attributable to the IPO proceeds.

Capital expenditures for the first nine months of 1996 were $5.1 million
compared to $1.1 million for the corresponding period of 1995. The increase in
1996 is primarily attributable to the expansion of clinical supply manufacturing
facilities and formulation development facilities, and additional scientific
instrumentation acquired to expand the capacity of laboratory operations.

In May 1996, the Company acquired an option to purchase the outstanding stock of
a European contract research and development organization. The Company paid
approximately $1.0 million to acquire such option, which amount is held in
escrow and will be applied to the purchase price if the Company elects to
exercise such option or returned to the Company if, prior to the expiration of
the option, certain substantial conditions are not satisfied. The Company is
currently conducting its due diligence review and, at this time, does not have
sufficient information to determine if this option will be exercised.  The
option terminates on November 28, 1996.

The Company expects to continue expanding its operations through internal growth
and strategic acquisitions. The Company expects such activities will be funded
from existing cash and cash equivalents, cash flow from operations and
borrowings under its credit line. The Company believes that such sources of cash
will be sufficient to fund operations for the foreseeable future and to pay
existing debt and other capital obligations as they become due. Although the
Company has no present acquisition agreements or arrangements other than
described above, there may be acquisition or other growth opportunities that
require additional external financing, and the Company may from time to time
seek to obtain funds from public or private issuances of equity or debt
securities. There can be no assurances that such financings will be available on
terms acceptable to the Company.



                                        8

<PAGE>   10



PART II  OTHER INFORMATION

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

         (a)      Exhibits

                  A list of the exhibits required to be filed as part of this
                  Report on Form 10-Q is set forth in the "Exhibit Index", which
                  immediately precedes such exhibits, and is incorporated herein
                  by reference.

         (b)      Reports on Form 8-K  (Not Applicable)




SIGNATURES


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                            APPLIED ANALYTICAL INDUSTRIES, INC.

Date:  November 14, 1996    By:    /s/ R. Forrest Waldon
                                   --------------------------------------------
                                   R. Forrest Waldon
                                   Vice President and Secretary
                                   (Duly Authorized Officer)

Date:  November 14, 1996    By:    /s/ Mark P. Colonnese
                                   --------------------------------------------
                                   Mark P. Colonnese
                                   Vice President and Chief Financial Officer
                                   (Principal Financial and Accounting Officer)



                                        9

<PAGE>   11
 
                                 EXHIBIT INDEX
 
<TABLE>
<CAPTION>
EXHIBIT                                                                               
  NO.                                     DESCRIPTION                        
- ------          --------------------------------------------------------------------- 
<C>        <C>  <S>                                                                   
  3.1        -- Amended and Restated Certificate of Incorporation of the Company
  3.2        -- Restated By-laws of the Company (incorporated by reference to 
                Exhibit 3.2 to the Company's Registration Statement on Form S-1 
                (Registration Statement No. 333-05535))
  4.1        -- Articles Fourth, Seventh, Eleventh and Twelfth of the Amended
                and Restated Certificate of Incorporation of the Company (included in
                Exhibit 3.1)
  4.2        -- Article II of the Restated By-laws of the Company (included
                in Exhibit 3.2)
  4.3        -- Specimen Certificate for shares of Common Stock, $.001 par value, of
                the Company (incorporated by reference to Exhibit 4.3
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.1        -- Employment Agreement dated November 17, 1995 between the Company and
                Frederick D. Sancilio (incorporated by reference to Exhibit 10.1
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.2        -- Applied Analytical Industries, Inc. 1995 Restricted Stock Award Plan 
                (incorporated by reference to Exhibit 10.2 to the Company's Registration 
                Statement on Form S-1 (Registration No. 333-05535))       
 10.3        -- Applied Analytical Industries, Inc. 1995 Stock Option Plan (incorporated 
                by reference to Exhibit 10.3 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.4        -- Applied Analytical Industries, Inc. 1996 Stock Option Plan (incorporated 
                by reference to Exhibit 10.4 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.5        -- Stockholder Agreement dated as of November 17, 1995 among the
                Company, GS Capital Partners II, L.P., GS Capital Partners II
                Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street
                Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley Partners
                III, L.P., Wakefield Group Limited Partnership, James L. Waters,
                Frederick D. Sancilio and the parties listed on Schedule 1 thereto 
                (incorporated by reference to Exhibit 10.5 to the Company's Registration 
                Statement on Form S-1 (Registration No. 333-05535))       
 10.6        -- Preferred Stock Purchase Agreement dated as of November 17, 1995
                among the Company, GS Capital Partners II, L.P., GS Capital Partners
                II Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone
                Street Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley
                Partners III, L.P., Wakefield Group Limited Partnership and James L.
                Waters (incorporated by reference to Exhibit 10.6 to the Company's 
                Registration Statement on Form S-1 (Registration No. 333-05535))       
 10.7        -- Loan Agreement dated as of December 21, 1992 between NationsBank, N.A.
                and the Company, together with the First Amendment and Second Amendment 
                thereto and agreement extending the term thereof (incorporated by 
                reference to Exhibit 10.7 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.8        -- Loan Agreement dated as of November 1, 1988 between the Company and
                The New Hanover County Industrial Facilities and Pollution Control
                Financing Authority (incorporated by reference to Exhibit 10.8
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.9        -- Letter of Credit Reimbursement Agreement dated November 1, 1988
                between NationsBank, N.A. and the Company (incorporated by 
                reference to Exhibit 10.9 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.10       -- Lease Agreement dated as of March 7, 1994 between 5051 New Centre
                Drive, L.L.C., as landlord, and the Company, as tenant (incorporated 
                by reference to Exhibit 10.10 to the Company's Registration Statement 
                on Form S-1 (Registration No. 333-05535))       
 10.11       -- Lease Agreement dated as of December 23, 1993 between I-40
                Properties, as landlord, and the Company, as tenant (incorporated by 
                reference to Exhibit 10.11 to the Company's Registration Statement on 
                Form S-1 (Registration No. 333-05535))       
 10.12       -- Development Agreement dated as of April 25, 1994 between the Company
                and Endeavor Pharmaceuticals, Inc. (f/n/a GenerEst, Inc.) 
                (incorporated by reference to Exhibit 10.12 to the Company's 
                Registration Statement on Form S-1 (Registration No. 333-05535))       
 10.13       -- Development Agreement dated as of April 4, 1995 between the Company
                and Aesgen, Inc. (incorporated by reference to Exhibit 10.13
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
 10.14*      -- Option Agreement dated May 28, 1996 with respect to an option granted
                to the Company to acquire a certain European contract research and
                development organization (incorporated by reference to Exhibit 10.14
                to the Company's Registration Statement on Form S-1 (Registration 
                No. 333-05535))       
</TABLE>

<PAGE>   12
 
<TABLE>
<CAPTION>
EXHIBIT                                                                               
  NO.                                     DESCRIPTION                        
- ------          --------------------------------------------------------------------- 
<C>        <C>  <S>                                                                   
 10.15       -- Letter dated August 22, 1996 from NationsBank, N.A. to the Company
                extending the maturity of certain indebtedness (incorporated by 
                reference to Exhibit 10.15 to the Company's Registration Statement 
                on Form S-1 (Registration No. 333-05535))       
 10.16       -- Registration Rights Agreement dated as of November 17, 1996 among the 
                Company, GS Capital Partners II, L.P., GS Capital Partners II 
                Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street 
                Fund 1995, L.P., Bridge Street Fund 1995, L.P., Noro-Moseley 
                Partners III, L.P., Wakefield Group Limited Partnership, James L. Waters, 
                Frederick D. Sancilio and the parties listed on Schedule 1 thereto 
                (incorporated by reference to Exhibit 10.16 to Post-effective
                Amendment No. 1 to the Company's Registration Statement on Form S-1 
                (Registration No. 333-05535))       
 10.17       -- Underwriting Agreement dated September 19, 1996 between the Company and 
                Goldman, Sachs & Co., Cowen & Company and Lehman Brothers, Inc., as 
                representatives of the underwriters listed on Schedule 1 thereto
 27          -- Financial Data Schedule (for SEC use only)
</TABLE>
 
- ---------------
 
  * Certain information has been omitted from this exhibit pursuant to a request
    for confidential treatment granted by the Securities and Exchange
    Commission on September 18, 1996.

<PAGE>   1
                                                                   EXHIBIT 3.1


                     RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                      APPLIED ANALYTICAL INDUSTRIES, INC.

                        PURSUANT TO SECTIONS 242 AND 245
                         OF THE GENERAL CORPORATION LAW
                            OF THE STATE OF DELAWARE


         APPLIED ANALYTICAL INDUSTRIES, INC., (the "Corporation"), a
corporation organized and existing under and by virtue of the General
Corporation Law of the State of Delaware (the "General Corporation Law"),
hereby certifies as follows:

         1.      The name of the Corporation is Applied Analytical Industries,
Inc.  The original Certificate of Incorporation was filed with the Secretary of
State of Delaware on September 29, 1986.

         2.      Pursuant to Section 103(d) of the General Corporation Law,
this Restated Certificate of Incorporation shall become effective at 10:00 a.m.,
Wilmington, Delaware time, on September 25, 1996.

         3.      This Restated Certificate of Incorporation: (a) restates and
integrates and further amends the Restated Certificate of Incorporation of the
Corporation that was adopted on November 17, 1995, (b) was duly adopted in
accordance with the provisions of Section 242 and 245 of the General
Corporation Law and (c) was approved by written consent of the stockholders of
the Corporation given in accordance with the provisions of Section 228 of the
General Corporation Law (prompt notice of such action having been given to
those stockholders who did not consent in writing).  The text of the
Corporation's Certificate of Incorporation as previously amended, supplemented
or restated is hereby further restated and further amended to read in its
entirety as follows:

         FIRST.  The name of the Corporation is:

                      Applied Analytical Industries, Inc.

         SECOND.  The address of its registered office in the State of Delaware
is Corporation Trust Center, 1209 Orange Street, in the City of Wilmington,
County of New Castle.  The name of its registered agent at such address is The
Corporation Trust Company.

         THIRD.  The nature of the business or purposes to be conducted or
promoted by the Corporation is as follows:

                 To engage in any lawful act or activity for which corporations
         may be organized under the General Corporation Law of Delaware.

         FOURTH.  The total number of shares of all classes of stock that the
Corporation shall have authority to issue is 105,000,000 shares, consisting of
(i) 100,000,000 shares of Common Stock, $.001 par value per share ("Common
Stock"), and (ii) 5,000,000 shares of Preferred Stock, $.001 par value per
share ("Preferred Stock").


<PAGE>   2

         The following is a statement of the designations and the powers,
privileges and rights, and the qualifications, limitations or restrictions
thereof in respect of each class of capital stock of the Corporation.

A.       COMMON STOCK

         1.      General.  The voting, dividend and liquidation rights of the
holders of the Common Stock are subject to and qualified by the rights of the
holders of the Preferred Stock of any series as may be designated by the Board
of Directors upon any issuance of the Preferred Stock of any series.

         2.      Voting.  The holders of the Common Stock are entitled to one
vote for each share held at all meetings of stockholders (and written actions
in lieu of meetings).  There shall be no cumulative voting.

         The number of authorized shares of Common Stock may be increased or
decreased (but not below the number of shares thereof then outstanding) by the
affirmative vote of the holders of a majority of the stock of the Corporation
entitled to vote, irrespective of the provisions of Section 242(b)(2) of the
General Corporation Law.

         3.      Dividends.  Dividends may be declared and paid on the Common
Stock from funds lawfully available therefor as and when determined by the
Board of Directors and subject to any preferential dividend rights of any then
outstanding Preferred Stock.

         4.      Liquidation.  Upon the dissolution or liquidation of the
Corporation, whether voluntary or involuntary, holders of Common Stock will be
entitled to receive all assets of the Corporation available for distribution to
its stockholders, subject to any preferential rights of any then outstanding
Preferred Stock.

B.       PREFERRED STOCK.

         Preferred Stock may be issued from time to time in one or more series,
each of such series to have such terms as stated or expressed herein and in the
resolution or resolutions providing for the issue of such series adopted by the
Board of Directors of the Corporation as hereinafter provided.  Any shares of
Preferred Stock that may be redeemed, purchased or acquired by the Corporation
may be reissued except as otherwise provided by law or this Certificate of
Incorporation.  Different series of Preferred Stock shall not be construed to
constitute different classes of shares for the purposes of voting by classes
unless expressly provided.

         Authority is hereby expressly granted to the Board of Directors from
time to time to issue the Preferred Stock in one or more series, and in
connection with the creation of any such series, by resolution or resolutions
providing for the issue of the shares thereof, to determine and fix such voting
powers, full or limited, or no voting powers, and such designations,
preferences and relative participating, optional or other special rights, and
qualifications, limitations or restrictions thereof, including without
limitation, dividend rights, conversion rights, redemption privileges and
liquidation preferences, as shall be stated and expressed in such resolutions,
all to the full extent now or hereafter permitted by the General Corporation
Law.  Without limiting the generality of the foregoing, the resolutions
providing for issuance of any series of Preferred Stock may provide that such
series shall be superior or rank equally or be junior to the Preferred Stock of
any other series to the extent permitted





                                      -2-
<PAGE>   3


by law and this Certificate of Incorporation.  Except as otherwise provided in
this Certificate of Incorporation, no vote of the holders of the Preferred
Stock or Common Stock shall be a prerequisite to the designation or issuance of
any shares of any series of the Preferred Stock authorized by and complying
with the conditions of this Certificate of Incorporation, the right to have
such vote being expressly waived by all present and future holders of the
capital stock of the Corporation.

         FIFTH.  The Corporation shall have a perpetual existence.

         SIXTH.  In furtherance of and not in limitation of powers conferred by
statute, the board of directors is expressly authorized to adopt, amend or
repeal the by-laws of the Corporation.

         SEVENTH.  Whenever a compromise or arrangement is proposed between
this Corporation and its creditors or any class of them and/or between this
Corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this Corporation or of any creditor or stockholder thereof, or on the
application of any receiver or receivers appointed for this Corporation under
the provisions of Section 291 of Title 8 of the Delaware Code or on the
application of trustees in dissolution or of any receiver or receivers
appointed for this Corporation under the provisions of section 279 of Title 8
of the Delaware Code order a meeting of the creditors or class of creditors,
and/or of the stockholders or class of stockholders of this Corporation, as the
case may be, to be summoned in such manner as the said court directs.  If a
majority in number representing three-fourths in value of the creditors or
class of creditors, and/or of the stockholders or class of stockholders of this
Corporation, as the case may be, agree to any compromise or arrangement and to
any reorganization of this Corporation as a consequence of such compromise or
arrangement, the said compromise or arrangement and the said reorganization
shall, if sanctioned by the court to which the said application has been made,
be binding on all the creditors or class of creditors, and/or on all the
stockholders or class of stockholders, of this Corporation, as the case may be,
and also on this Corporation.

         EIGHTH.  Except to the extent that the General Corporation Law
prohibits the elimination or limitation of liability of directors for breaches
of fiduciary duty, no director of the Corporation shall be personally liable to
the Corporation or its stockholders for monetary damages for any breach of
fiduciary duty as a director, notwithstanding any other provision of law
imposing such liability.  No amendment to or repeal of this provision shall
apply to or have any effect on the liability or alleged liability of any
director of the Corporation for or with respect to any acts or omissions of
such director occurring prior to such amendment.

         NINTH.  The Corporation reserves the right to amend, alter, change or
repeal any provision contained in this Restated Certificate of Incorporation,
in the manner now or hereafter prescribed by statute and this Restated
Certificate of Incorporation, and all rights conferred upon stockholders herein
are granted subject to this reservation.

         TENTH:  This Article is inserted for the management of the business
and for the conduct of the affairs of the Corporation.

         1.      Number of Directors.  The number of directors of the
Corporation shall not be less than three (3) nor more than seven (7).  The
exact number of directors within the limitations specified in the preceding
sentence shall be fixed from time to time by, or in the manner provided in, the
Corporation's By-Laws.





                                      -3-
<PAGE>   4


         2.      Classes of Directors.  The Board of Directors shall be and is
divided into three classes:  Class I, Class II and Class III.  No one class
shall have more than one director more than any other class.  If a fraction is
contained in the quotient arrived at by dividing the designated number of
directors by three, then, if such fraction is one-third, the extra director
shall be a member of Class I, and if such fraction is two-thirds, one of the
extra directors shall be a member of Class I and one of the extra directors
shall be a member of Class II, unless otherwise provided from time to time by
resolution adopted by the Board of Directors.

   3.      Election of Directors.  Elections of directors must be by written
ballot.

         4.      Terms of Office.  Each director shall serve for a term ending
on the date of the third annual meeting following the annual meeting at which
such director was elected; provided, that each initial director in Class I
shall serve for a term ending on the date of the annual meeting in 1997; each
initial director in Class II shall serve for a term ending on the date of the
annual meeting in 1998; and each initial director in Class III shall serve for
a term ending on the date of the annual meeting in 1999; and provided further,
that the term of each director shall be subject to the election and
qualification of his successor and to his earlier death, resignation or
removal.

         5.      Allocation of Directors Among Classes in the Event of
Increases or Decreases in the Number of Directors.  In the event of any
increase or decrease in the authorized number of directors, (i) each director
then serving as such shall nevertheless continue as a director of the class of
which he is a member and (ii) the newly created or eliminated directorships
resulting from such increase or decrease shall be apportioned by the Board of
Directors among the three classes of directors so as to ensure that no one
class has more than one director more than any other class.  To the extent
possible, consistent with the foregoing rule, any newly created directorships
shall be added to those classes whose terms of office are to expire at the
latest dates following such allocation, and any newly eliminated directorships
shall be subtracted from those classes whose terms of offices are to expire at
the earliest dates following such allocation, unless otherwise provided from
time to time by resolution adopted by the Board of Directors.

         6.      Quorum; Action at Meeting.  A majority of the directors at any
time in office shall constitute a quorum for the transaction of business.  In
the event one or more of the directors shall be disqualified to vote at any
meeting, then the required quorum shall be reduced by one for each director so
disqualified, provided that in no case shall less than one-third of the number
of directors fixed pursuant to Section 1 above constitute a quorum.  If at any
meeting of the Board of Directors there shall be less than such a quorum, a
majority of those present may adjourn the meeting from time to time.  Every act
or decision done or made by a majority of the directors present at a meeting
duly held at which a quorum is present shall be regarded as the act of the
Board of Directors unless a greater number is required by law, by the By-Laws
of the Corporation or by this Restated Certificate of Incorporation.

         7.      Resignation; Removal.  Any director may resign at any time
upon written notice to the attention of the secretary of the corporation.
Directors of the Corporation may be removed only for cause by the affirmative
vote of the holders of at least two-thirds of the shares of the capital stock
of the Corporation issued and outstanding and entitled to vote.

         8.      Vacancies.  Any vacancy in the Board of Directors, however
occurring, including a vacancy resulting from an enlargement of the board,
shall be filled only by a vote of a majority of the directors then in office,
although less than a quorum, or by a sole remaining director.  A director
elected





                                      -4-
<PAGE>   5


to fill a vacancy shall be elected to hold office until the next election of
the class for which such director shall have been chosen, subject to the
election and qualification of his successor and to his earlier death,
resignation or removal.

         9.      Amendments to Article.  Notwithstanding any other provisions
of law, this Restated Certificate of Incorporation or the By-Laws of the
Corporation, each as amended, and notwithstanding the fact that a lesser
percentage may be specified by law, the affirmative vote of the holders of at
least seventy-five percent (75%) of the shares of capital stock of the
Corporation issued and outstanding and entitled to vote shall be required to
amend or repeal, or to adopt any provision inconsistent with, this Article
TENTH.

         ELEVENTH.  Stockholders of the Corporation may not take any action by
written consent in lieu of a meeting.  Notwithstanding any other provisions of
law, this Restated Certificate of Incorporation or the By-Laws of the
Corporation, each as amended, and notwithstanding the fact that a lesser
percentage may be specified by law, the affirmative vote of the holders of at
least seventy-five percent (75%) of the shares of capital stock of the
Corporation issued and outstanding and entitled to vote shall be required to
amend or repeal, or to adopt any provision inconsistent with, this Article
ELEVENTH.

         TWELFTH.  Special meetings of stockholders may be called at any time
by (and only by) the Board of Directors.  Business transacted at any special
meeting of stockholders shall be limited to matters relating to the purpose or
purposes stated in the notice of meeting.  Notwithstanding any other provision
of law, this Restated Certificate of Incorporation or the By-Laws of the
Corporation, each as amended, and notwithstanding the fact that a lesser
percentage may be specified by law, the affirmative vote of the holders of at
least seventy-five percent (75%) of the shares of capital stock of the
Corporation issued and outstanding and entitled to vote shall be required to
amend or repeal, or to adopt any provisions inconsistent with, this Article
TWELFTH.

         THIRTEENTH.  In anticipation that the Corporation may enter into
contracts or otherwise transact business with entities in which any directors
of the Corporation own a financial interest ("Related Entities"), the
provisions of this Article THIRTEENTH are set forth to regulate and guide such
contracts or other business.  These provisions are in addition to, and not in
limitation of, the provisions of the General Corporation Law and the other
provisions of this Restated Certificate of Incorporation.  Any contract or
other business that does not comply with the procedures set forth in this
Article THIRTEENTH shall not by reason thereof be deemed void or voidable or
result in any breach of any duty or the derivation of any improper personal
benefit by any person but shall be governed by the provisions of this Restated
Certificate of Incorporation, the By-laws of the Corporation, the General
Corporation Law and other applicable law.

         No contract, agreement, arrangement or transaction between the
Corporation and a Related Entity (a "Related Transaction") shall be void or
voidable solely for the reason that such persons or entities are parties
thereto, if:

         (i)     the material facts of the Related Transaction are disclosed or
                 are known to the Board of Directors of the Corporation (or a
                 committee thereof) and such board (or committee) in good faith
                 authorizes, approves or ratifies the Related Transaction by
                 the affirmative vote of a majority of the disinterested
                 directors on the Board of Directors (or such committee), even
                 though the disinterested directors may be less than a quorum;





                                      -5-
<PAGE>   6


         (ii)    the material facts of the Related Transaction are disclosed or
                 are known to the holders of the then outstanding voting shares
                 of the Corporation entitled to vote thereon, and the Related
                 Transaction is specifically approved or ratified in good faith
                 by the affirmative vote of the holders of a majority of the
                 then outstanding voting shares not owned by the interested
                 directors or Related Entity, as the case may be, even though
                 such holders may be less than a quorum;

         (iii)   such Related Transaction is effected pursuant to and
                 consistent with terms and conditions specified in any
                 arrangements, standards or guidelines that are in good faith
                 authorized, approved or ratified, after disclosure or
                 knowledge of the material facts related thereto, by the
                 affirmative vote of a majority of the disinterested directors
                 on the Board of Directors (or committee thereof), or by the
                 affirmative vote of the holders of a majority of the then
                 outstanding voting shares of the Corporation not owned by the
                 interested directors or Related Entity, as the case may be,
                 even though the disinterested directors or such holders may be
                 less than a quorum; or

         (iv)    The Related Transaction was fair to the Company.

         In addition, each Related Transaction authorized, approved or
effected, and each of such arrangements, standards or guidelines so authorized
or approved, as described in (i), (ii) or (iii) above, shall be conclusively
deemed to be fair to the Corporation and its stockholders; provided, however,
that if such authorization or approval is not obtained, or such Related
Transaction is not so effected, no presumption shall arise that such Related
Transaction, or such arrangements, standards or guidelines, are not fair to the
Corporation and its stockholders.

         Any person or entity purchasing or otherwise acquiring any interest in
any shares of the Corporation shall be deemed to have notice of and to have
consented to the provisions of this Article THIRTEENTH.

         IN WITNESS WHEREOF, the Corporation has caused its corporate seal to
be affixed hereto and this Restated Certificate of Incorporation to be signed
by its President this 20th day of September, 1996.



                                        APPLIED ANALYTICAL INDUSTRIES, INC.


                                        By: /s/ Frederick D. Sancilio
                                            --------------------------------
                                            Frederick D. Sancilio, President



ATTEST:

     /s/ R. Forrest Waldon
- ---------------------------------
   R. Forrest Waldon, Secretary





                                      -6-

<PAGE>   1
                                                                 EXHIBIT 10.17


                      APPLIED ANALYTICAL INDUSTRIES, INC.

                                  COMMON STOCK

                          (PAR VALUE $.001 PER SHARE)

                                  -------------



                             UNDERWRITING AGREEMENT
                             ----------------------



                                                           September 19, 1996

Goldman, Sachs & Co.,
Cowen & Company,
Lehman Brothers Inc.,
 As representatives of the several Underwriters
  named in Schedule I hereto,
c/o Goldman, Sachs & Co.,
85 Broad Street,
New York, New York 10004

Ladies and Gentlemen:

     Applied Analytical Industries, Inc., a Delaware corporation (the
"Company"), proposes, subject to the terms and conditions stated herein, to
issue and sell to the Underwriters named in Schedule I hereto (the
"Underwriters") an aggregate of 2,700,000 shares (the "Firm Shares") and, at the
election of the Underwriters, up to 405,000 additional shares (the "Optional
Shares") of Common Stock, par value $.001 per share ("Stock"), of the Company
(the Firm Shares and the Optional Shares that the Underwriters elect to
purchase pursuant to Section 2 hereof being collectively called the "Shares").

     1. The Company represents and warrants to, and agrees with, each of the
Underwriters that:

          (a) A registration statement on Form S-1 (File No. 333-05535) (the
     "Initial Registration Statement") in respect of the Shares, and as part
     thereof the respective forms of prospectus relating to the initial
     distribution of the Shares by the Underwriters in an underwritten public
     offering and to offers and sales of Stock by Goldman, Sachs & Co. in
     secondary transactions, has been filed with the Securities and Exchange
     Commission (the "Commission"); the Initial Registration Statement and any
     post-effective amendment thereto, each in the form heretofore delivered to
     you, and, excluding exhibits thereto, to you for each of the other
     Underwriters, have been declared effective by the Commission in such form;
     other than a registration statement, if any, increasing the size of the
     offering (a "Rule 462(b) Registration Statement"), filed pursuant to Rule
     462(b) under the Securities Act of 1933, as amended (the 


<PAGE>   2




     "Act") which became effective upon filing, no other document with
     respect to the Initial Registration Statement has heretofore been filed
     with the Commission; and no stop order suspending the effectiveness of the
     Initial Registration Statement, any post-effective amendment thereto or
     the Rule 462(b) Registration Statement, if any, has been issued and no
     proceeding for that purpose has been initiated or threatened by the
     Commission (any preliminary prospectus included in the Initial
     Registration Statement or filed with the Commission pursuant to Rule
     424(a) of the rules and regulations of the Commission under the Act, is
     hereinafter called a "Preliminary Prospectus"; the various parts of the
     September 16, 1996 Initial Registration Statement and the Rule 462(b)
     Registration Statement, if any, including all exhibits thereto and
     including the information contained in the form of final prospectus filed
     with the Commission pursuant to Rule 424(b) under the Act in accordance
     with Section 5(a) hereof and deemed by virtue of Rule 430A under the Act
     to be part of the Initial Registration Statement at the time it was
     declared effective or such part of the Rule 462(b) Registration Statement,
     if any, which became or hereafter becomes effective, each as amended at
     the time such part of the registration statement became effective, is
     hereinafter collectively called the "Registration Statement"; and such
     forms of final prospectus relating to the initial distribution of the
     Shares by the Underwriters in an underwritten public offering in the form
     first filed pursuant to Rule 424(b) under the Act and to offers and sales
     of Stock by Goldman, Sachs & Co. in secondary transactions in the most
     recent form filed pursuant to Rule 424(b) under the Act, are hereinafter
     called the "Public Offering Prospectus" and the "Secondary Transactions
     Prospectus", respectively, and collectively, the "Prospectus");

          (b) No order preventing or suspending the use of any Preliminary
     Prospectus has been issued by the Commission, and each Preliminary
     Prospectus, at the time of filing thereof, conformed in all material
     respects to the requirements of the Act and the rules and regulations of
     the Commission thereunder, and did not contain an untrue statement of a
     material fact or omit to state a material fact required to be stated
     therein or necessary to make the statements therein, in the light of the
     circumstances under which they were made, not misleading; provided,
     however, that this representation and warranty shall not apply to any
     statements or omissions made in reliance upon and in conformity with
     information furnished in writing to the Company by an Underwriter through
     Goldman, Sachs & Co. expressly for use therein;

          (c) The Registration Statement conforms, and the Prospectus and any
     further amendments or supplements to the Registration Statement or the
     Prospectus will conform, in all material respects to the requirements of
     the Act and the rules and regulations of the Commission thereunder and do
     not and will not, as of the applicable effective date as to the
     Registration Statement and any amendment thereto, and as of the applicable
     filing date as to the Prospectus and any amendment or supplement thereto,
     contain an untrue statement of a material fact or omit to state a material
     fact required to be stated therein or necessary to make the statements
     therein not misleading; provided, however, that this representation and
     warranty shall not apply to any statements or omissions made in reliance
     upon and in conformity with information furnished in writing to the
     Company by an Underwriter through Goldman, Sachs & Co. expressly for use
     therein;

          (d) Neither the Company nor any entity 50% or more of the outstanding
     voting securities of which are owned directly or indirectly by the Company
     (each, a "subsidiary"), has sustained since the date of the latest audited
     financial statements included in the Prospectus any material loss or
     interference with its business from fire, explosion, flood or other
     calamity, 


                                      2

<PAGE>   3




     whether or not covered by insurance, or from any labor dispute or court
     or governmental action, order or decree, otherwise than as set forth or
     contemplated in the Prospectus; and, since the respective dates as of
     which information is given in the Registration Statement and the
     Prospectus, there has not been any change in the capital stock or any
     increase in excess of $250,000 in the long-term debt of the Company or any
     of its subsidiaries or any material adverse change, or any development
     involving a prospective material adverse change, in or affecting the
     general affairs, management, financial position, stockholders' equity or
     results of operations of the Company and its subsidiaries, taken as a
     whole, otherwise than as set forth or contemplated in the Prospectus;

          (e) The Company and its subsidiaries have good and marketable title
     in fee simple to all real property and good and marketable title to all
     personal property owned by them, in each case free and clear of all liens,
     encumbrances and defects except such as are described in the Prospectus or
     such as do not materially affect the value of such property and do not
     interfere with the use made and proposed to be made of such property by
     the Company and its subsidiaries; and any real property and buildings held
     under lease by the Company and its subsidiaries are held by them under
     valid, subsisting and enforceable leases with such exceptions as are not
     material and do not interfere with the use made and proposed to be made of
     such property and buildings by the Company and its subsidiaries;

          (f) The Company has been duly incorporated and is validly existing as
     a corporation in good standing under the laws of the State of Delaware,
     with power and authority (corporate and other) to own its properties and
     conduct its business as described in the Prospectus, and has been duly
     qualified as a foreign corporation for the transaction of business and is
     in good standing under the laws of each other jurisdiction in which it
     owns or leases properties or conducts any business so as to require such
     qualification, or is subject to no material liability or disability by
     reason of the failure to be so qualified in any such jurisdiction or is
     subject to no material liability or disability by reason of the failure to
     be so qualified in any such jurisdiction; and each subsidiary of the
     Company has been duly incorporated and is validly existing as a
     corporation in good standing under the laws of its jurisdiction of
     incorporation;

          (g) The Company has an authorized capitalization as set forth in the
     Prospectus, and all of the issued shares of capital stock of the Company
     have been duly and validly authorized and issued, are fully paid and
     non-assessable and conform to the description of the Stock contained in
     the Prospectus; and all of the issued shares of capital stock of each
     subsidiary of the Company have been duly and validly authorized and
     issued, are fully paid and non-assessable and (except for directors'
     qualifying shares) are owned directly or indirectly by the Company, free
     and clear of all liens, encumbrances, equities or claims;

          (h) The unissued Shares to be issued and sold by the Company to the
     Underwriters hereunder have been duly and validly authorized and, when
     issued and delivered against payment therefor as provided herein, will be
     duly and validly issued and fully paid and non-assessable and will conform
     to the description of the Stock contained in the Prospectus;

          (i) The issue and sale of the Shares by the Company and the
     compliance by the Company with all of the provisions of this Agreement and
     the consummation of the transactions herein contemplated will not conflict
     with or result in a breach or violation of any of the terms or provisions
     of, or constitute a default under, any indenture, mortgage, deed of trust,
     loan agreement or other agreement or instrument to which the Company or
     any of its subsidiaries is a party or by which the Company or any of its



                                      3

<PAGE>   4



     subsidiaries is bound or to which any of the property or assets of the
     Company or any of its subsidiaries is subject, nor will such action result
     in any violation of the provisions of the Certificate of Incorporation or
     By-laws of the Company or any statute or any order, rule or regulation of
     any court or governmental agency or body having jurisdiction over the
     Company or any of its subsidiaries or any of their properties; and no
     consent, approval, authorization, order, registration or qualification of
     or with any such court or governmental agency or body is required for the
     issue and sale of the Shares or the consummation by the Company of the
     transactions contemplated by this Agreement, except the registration under
     the Act of the Shares, registration of Stock under the Securities Exchange
     Act of 1934 (the "1934 Act") and such consents, approvals, authorizations,
     registrations or qualifications as may be required under state securities
     or Blue Sky laws in connection with the purchase and distribution of the
     Shares by the Underwriters;

          (j) Neither the Company nor any of its subsidiaries is in violation
     of its Certificate of Incorporation or By-laws or in default in the
     performance or observance of any material obligation, agreement, covenant
     or condition contained in any indenture, mortgage, deed of trust, loan
     agreement, lease or other agreement or instrument to which it is a party
     or by which it or any of its properties may be bound;

          (k) The statements set forth in the Prospectus under the caption
     "Description of Capital Stock", insofar as they purport to constitute a
     summary of the terms of the Stock, and under the caption "Underwriting",
     insofar as they purport to describe the provisions of the laws and
     documents referred to therein, are accurate, complete and fair;

          (l) Other than as set forth in the Prospectus, there are no legal or
     governmental proceedings (other than pending review by the U.S. Food and
     Drug Administration (the "FDA") of any abbreviated new drug application
     and related filings submitted by the Company and routine FDA audits of the
     Company, its facilities and data supporting filings made by clients of the
     Company) pending to which the Company or any of its subsidiaries is a
     party or of which any property of the Company or any of its subsidiaries
     is the subject which, if determined adversely to the Company or any of its
     subsidiaries, would individually or in the aggregate have a material
     adverse effect on the current or future consolidated financial position,
     stockholders' equity or results of operations of the Company and its
     subsidiaries; and, to the best of the Company's knowledge, no such
     proceedings are threatened or contemplated by governmental authorities or
     threatened by others;

          (m) The Company is not and, after giving effect to the offering and
     sale of the Shares, will not be an "investment company" or an entity
     "controlled" by an "investment company", as such terms are defined in the
     Investment Company Act of 1940, as amended (the "Investment Company Act");

          (n) Neither the Company nor any of its affiliates does business with
     the government of Cuba or with any person or affiliate located in Cuba
     within the meaning of Section 517.075, Florida Statutes; and

          (o) Price Waterhouse, LLP, who have certified certain financial
     statements of the Company and its subsidiaries, and McGladrey & Pullen,
     who have certified certain financial statements of the Company and its
     subsidiaries, are each independent public accountants as required by the
     Act and the rules and regulations of the Commission thereunder.


                                      4

<PAGE>   5




          (p) The Company and its subsidiaries are in material compliance with
     all current applicable statutes, rules, regulations, standards, guides or
     orders administered or issued by the FDA and any agency of any foreign
     government, to the extent applicable; neither the Company nor any of its
     subsidiaries has received any communication (including, any warning
     letter) or is otherwise aware of any action, proceeding or investigation
     pending or, to the best knowledge of the Company, threatened, including,
     without limitation, any warning letter, prosecution, injunction, seizure,
     civil fine or recall, alleging that the Company is not in compliance in
     all material respects with any and all applicable laws, regulations or
     orders implemented by the FDA, or implemented by the relevant state, local
     or international agency responsible for regulating the pharmaceutical
     industry, including but not limited to, allegations related to drug
     development establishments operated by the Company or its subsidiaries and
     drug applications submitted directly by the Company or its subsidiaries,
     other than non-material correspondence received from the FDA in connection
     with the filing and review of applications; with regard to all abbreviated
     new drug applications and related filings by the Company or any of its
     subsidiaries in its own name or, to its knowledge, all abbreviated new
     drug applications and related filings by third parties in connection with
     which the Company expects to receive revenue pending before the FDA, there
     is no correspondence or other communications from the FDA questioning the
     approvability of such applications other than as would not have a material
     adverse effect on the current or future consolidated financial position,
     stockholders' equity or results of operations of the Company and its
     subsidiaries;

          (q) (A) The Company and its subsidiaries own or have valid, binding,
     enforceable licenses or other rights to use any patents, trademarks,
     trade names, service marks, service names, copyrights, and other
     proprietary intellectual property rights ("Intellectual Property")
     necessary to conduct the business of the Company and its subsidiaries in
     the manner presently conducted and, to the best knowledge of the Company,
     proposed to be conducted, in the United States and to conduct the business
     of the Company and its subsidiaries in the manner presently conducted and,
     to the best knowledge of the Company proposed to be conducted, outside the
     United States other than as would not have a material adverse effect on
     the current or future consolidated financial position, stockholders'
     equity or results of operations of the Company and its subsidiaries, in
     each case without any conflict with the rights of others; and (B) the
     information contained in the Registration Statement and Prospectus
     concerning patents issued or licensed to, or patent applications filed on
     behalf of, the Company and its subsidiaries is accurate in all material
     respects; and (C) neither the Company nor its subsidiaries has received
     any notice from any other person of infringment of or conflict with (and
     knows of no such infringement of or conflict with) asserted rights of
     others with respect to any Intellectual Property or any trade secrets,
     proprietary information, inventions, know-how, processes and procedures
     owned or used by or licensed to the Company or its subsidiaries;

          (r) The Company and its subsidiaries are insured by insurers of
     recognized financial responsibility against losses and risks and in
     amounts as are prudent and customary in the businesses in which they are
     engaged; and neither the Company nor any of its subsidiaries has any
     reason to believe that they will not be able to renew their existing
     insurance coverage as and when such coverage expires or to obtain similar
     coverage from similar insurers as may be necessary to continue their
     businesses at a cost that would not have a material adverse effect on the
     current or future consolidated financial position, stockholders' equity or
     results of 



                                      5

<PAGE>   6




     operations of the Company and its subsidiaries except as described or 
     contemplated in the Prospectus;

          (s) The Company and its subsidiaries are in compliance with all
     applicable existing Federal, state, local, and foreign laws and
     regulations relating to protection of human health or the environment or
     imposing liability or standards of conduct concerning any Hazardous
     Material (as hereinafter defined) ("Environmental Laws"), except where
     such noncompliance with Environmental Laws would not, individually or in
     the aggregate, have a material adverse effect on the current or future
     consolidated financial position, stockholders' equity or results of
     operations of the Company and its subsidiaries.  The term "Hazardous
     Material" means (1) any "hazardous substance" as defined by the
     Comprehensive Environmental Response, Compensation and Liability Act of
     1980, as amended, (2) any "hazardous waste" as defined by the Resource
     Conservation and Recovery Act, as amended, (3) any petroleum or petroleum
     product, (4) any polychlorinated biphenyl, and (5) any pollutant or
     contaminant or hazardous, dangerous, or toxic chemical, material, waste or
     substance regulated under or within the meaning of any other Environmental
     Law; and

          (t) There are no debt securities or preferred stock of the Company
     which are rated by any "nationally recognized statistical rating
     organization", as that term is defined by the Commission for purposes of
     Rule 436(g)(2) under the Act.

     2. Subject to the terms and conditions herein set forth, (a) the Company
agrees to issue and sell to each of the Underwriters, and each of the
Underwriters agrees, severally and not jointly, to purchase from the Company, at
a purchase price per share of $14.88, the number of Firm Shares set forth
opposite the name of such Underwriter in Schedule I hereto and (b) in the event
and to the extent that the Underwriters shall exercise the election to purchase
Optional Shares as provided below, the Company agrees to issue and sell to each
of the Underwriters, and each of the Underwriters agrees, severally and not
jointly, to purchase from the Company, at the purchase price per share set forth
in clause (a) of this Section 2, that portion of the number of Optional Shares
as to which such election shall have been exercised (to be adjusted by you so as
to eliminate fractional shares) determined by multiplying such number of
Optional Shares by a fraction, the numerator of which is the maximum number of
Optional Shares which such Underwriter is entitled to purchase as set forth
opposite the name of such Underwriter in Schedule I hereto and the denominator
of which is the maximum number of Optional Shares that all of the Underwriters
are entitled to purchase hereunder.

     The Company hereby grants to the Underwriters the right to purchase at
their election up to 405,000 Optional Shares, at the purchase price per share
set forth in the paragraph above, for the sole purpose of covering
overallotments in the sale of the Firm Shares.  Any such election to purchase
Optional Shares may be exercised only by written notice from you to the Company,
given within a period of 30 calendar days after the date of this Agreement,
setting forth the aggregate number of Optional Shares to be purchased and the
date on which such Optional Shares are to be delivered, as determined by you but
in no event earlier than the First Time of Delivery (as defined in Section 4
hereof) or, unless you and the Company otherwise agree in writing, earlier than
two or later than ten business days after the date of such notice.

     3. Upon the authorization by you of the release of the Firm Shares, the
several Underwriters propose to offer the Firm Shares for sale upon the terms
and conditions set forth in the Public Offering Prospectus.


                                      6

<PAGE>   7




4.      (a) The Shares to be purchased by each Underwriter hereunder, in
definitive form, and in such authorized denominations and registered in
such names as Goldman, Sachs & Co. may request upon at least forty-eight
hours' prior notice to the Company, shall be delivered by or on behalf of
the Company to Goldman, Sachs & Co., for the account of such Underwriter,
against payment by or on behalf of such Underwriter of the purchase price
therefor by wire transfer, payable to the order of the Company in Federal
(same day) funds.  The Company will cause the certificates representing
the Shares to be made available for checking and packaging at least
twenty-four hours prior to the Time of Delivery (as defined below) with
respect thereto at the office of Goldman, Sachs & Co., 85 Broad Street,
New York, New York 10004 (the "Designated Office").  The time and date of
such delivery and payment shall be, with respect to the Firm Shares, 9:30
a.m., New York City time, on September 25, 1996 or such other time and
date as Goldman, Sachs & Co. and the Company may agree upon in writing,
and, with respect to the Optional Shares, 9:30 a.m., New York City time,
on the date specified by Goldman, Sachs & Co. in the written notice given
by Goldman, Sachs & Co. of the Underwriters' election to purchase such
Optional Shares in accordance with Section 2 hereof, or such other time
and date as Goldman, Sachs & Co. and the Company may agree upon in
writing.  Such time and date for delivery of the Firm Shares is herein
called the "First Time of Delivery", such time and date for delivery of
the Optional Shares, if not the First Time of Delivery, is herein called
the "Second Time of Delivery", and each such time and date for delivery is
herein called a "Time of Delivery".

        (b) The documents to be delivered at each Time of Delivery by or on
behalf of the parties hereto pursuant to Section 8 hereof, including the
cross receipt for the Shares and any additional documents requested by the
Underwriters pursuant to Section 8(l) hereof, will be delivered at the
offices of Fried, Frank, Harris, Shriver & Jacobson, One New York Plaza,
New York, New York 10004 (the "Closing Location"), and the Shares will be
delivered at the Designated Office, all at such Time of Delivery.  A
meeting will be held at the Closing Location at 2:00 p.m., New York City
time, on the New York Business Day next preceding such Time of Delivery,
at which meeting the final drafts of the documents to be delivered
pursuant to the preceding sentence will be available for review by the
parties hereto.  For the purposes of this Section 4, "New York Business
Day" shall mean each Monday, Tuesday, Wednesday, Thursday and Friday which
is not a day on which banking institutions in New York are generally
authorized or obligated by law or executive order to close.

5.      The Company agrees with each of the Underwriters:

        (a) To prepare the Public Offering Prospectus in a form approved by
you and to file the Public Offering Prospectus pursuant to Rule 424(b)
under the Act not later than the Commission's close of business on the
second business day following the execution and delivery of this
Agreement, or, if applicable, such earlier time as may be required by Rule
430A(a)(3) under the Act; to make no further amendment or any supplement
to the Registration Statement or the Public Offering Prospectus during the
Public Offering Period (as defined below) which shall be disapproved by
you promptly after reasonable notice thereof; to advise you, promptly
after it receives notice thereof during the Public Offering Period, of the
time when any amendment to the Registration Statement has been filed or
becomes effective during such period or any supplement to the Public
Offering Prospectus or any amended Public Offering Prospectus has been
filed during such period and to furnish you with copies thereof; to advise
you, promptly after it receives notice thereof during the Public Offering


                                      7

<PAGE>   8




Period, of the issuance by the Commission of any stop order or of any
order preventing or suspending the use of any Preliminary Prospectus or
prospectus, of the suspension of the qualification of the Shares for offering
or sale in any jurisdiction, of the initiation or threatening of any proceeding
for any such purpose, or of any request by the Commission for the amending or
supplementing of the Registration Statement or the Public Offering Prospectus
or for additional information; and, in the event of the issuance of any stop
order or of any order preventing or suspending the use of any Preliminary
Prospectus or prospectus or suspending any such qualification during the Public
Offering Period, promptly to use its best efforts to obtain the withdrawal of
such order (the period beginning on the date hereof and continuing for as long
as the delivery of a prospectus is required in connection with the initial
offering and sale of the Shares by the Underwriters as contemplated by the
Public Offering Prospectus, or in connection with any subsequent offer or sale
of Stock by a dealer other than Goldman, Sachs & Co. during the period
specified in Rule 174 under the Act is herein called the "Public Offering
Period");

        (b) Promptly during the Public Offering Period from time to time to
take such action as you may reasonably request to qualify the Shares for
offering and sale under the securities laws of such jurisdictions as you
may request and to comply with such laws so as to permit the continuance
of sales and dealings therein in such jurisdictions during such period,
provided that in connection therewith the Company shall not be required to
qualify as a foreign corporation or to file a general consent to service
of process in any jurisdiction;

        (c) Prior to 10:00 a.m., New York City time, on the New York Business
Day next succeeding the date of this Agreement and from time to time
during the Public Offering Period, to furnish the Underwriters with copies
of the Public Offering Prospectus in New York City in such quantities as
you may reasonably request, and, if the delivery of a prospectus is
required at any time prior to the expiration of nine months after the time
of issue of the Public Offering Prospectus in connection with any offering
or sale of the Shares by the Underwriters and if at such time any event
shall have occurred as a result of which the Public Offering Prospectus as
then amended or supplemented would include an untrue statement of a
material fact or omit to state any material fact necessary in order to
make the statements therein, in the light of the circumstances under which
they were made when such Public Offering Prospectus is delivered, not
misleading, or, if for any other reason it shall be necessary during such
period to amend or supplement the Public Offering Prospectus in order to
comply with the Act, to notify you and upon your request to prepare and
furnish without charge to each Underwriter and to any dealer in securities
as many copies as you may reasonably request of an amended Public Offering
Prospectus or a supplement to the Public Offering Prospectus which will
correct such statement or omission or effect such compliance, and in case
any Underwriter is required to deliver a prospectus in connection with any
offering or sale of any of the Shares by the Underwriters at any time nine
months or more after the time of issue of the Public Offering Prospectus,
upon your request but at the expense of such Underwriter, to prepare and
deliver to such Underwriter as many copies as you may request of an
amended or supplemented Public Offering Prospectus complying with Section
10(a)(3) of the Act;

        (d) To make generally available to its securityholders as soon as
practicable, but in any event not later than eighteen months after the
effective date of the Registration Statement (as defined in Rule 158(c)
under the Act), an earnings statement of the Company and its 



                                      8

<PAGE>   9



subsidiaries (which need not be audited) complying with Section 11(a)
of the Act and the rules and regulations thereunder (including, at the option
of the Company, Rule 158);

        (e) During the period beginning from the date hereof and continuing to
and including the date 180 days after the date of the Prospectus, (i) not to
offer, sell, contract to sell or otherwise dispose of, except as provided
hereunder any securities of the Company that are substantially similar to the
Shares, including but not limited to any securities that are convertible into
or exchangeable for, or that represent the right to receive, Stock or any such
substantially similar securities (other than pursuant to employee stock option
plans existing on, or upon the conversion or exchange of convertible or
exchangeable securities outstanding as of, the date of this Agreement), without
your prior written consent and (ii) during such 180-day period, not to
accelerate the vesting of any shares of Common Stock awarded under the 1995
Restricted Stock Award Plan and not to deliver certificates representing any
shares of Common Stock under the 1995 Restricted Stock Award Plan;

        (f) To furnish to its stockholders as soon as practicable after the end
of each fiscal year an annual report (including a balance sheet and statements
of income, stockholders' equity and cash flows of the Company and its
consolidated subsidiaries certified by independent public accountants) and, as
soon as practicable after the end of each of the first three quarters of each
fiscal year (beginning with the fiscal quarter ending after the effective date
of the Registration Statement), consolidated summary financial information of
the Company and its subsidiaries for such quarter in reasonable detail;

        (g) During a period of five years from the effective date of the
Registration Statement, to furnish to you copies of all reports or other
communications (financial or other) furnished to stockholders, and to deliver
to you (i) as soon as they are available, copies of any reports and financial
statements furnished to or filed with the Commission or any inter-dealer
quotation system or any national securities exchange on which any class of
securities of the Company is listed; and (ii) such additional information
concerning the business and financial condition of the Company as you may from
time to time reasonably request (such financial statements to be on a
consolidated basis to the extent the accounts of the Company and its
subsidiaries are consolidated in reports furnished to its stockholders
generally or to the Commission);

        (h) To use the net proceeds received by it from the sale of the Shares
pursuant to this Agreement in the manner specified in the Prospectus under the
caption "Use of Proceeds";

        (i) To use its best efforts to list for quotation the Shares on the
National Association of Securities Dealers Automated Quotations National Market
System ("NASDAQ");

        (j) To file with the Commission such reports on Form SR as may be
required by Rule 463 under the Act; and

        (k) If the Company elects to rely upon Rule 462(b), to file a Rule
462(b) Registration Statement with the Commission in compliance with Rule
462(b) by 10:00 P.M., Washington, D.C. time, on the date of this Agreement, and
at the time of filing to either pay to the Commission the filing fee for the
462(b) Registration Statement or give irrevocable instructions for the payment
of such fee pursuant to Rule 111(b) under the Act.


                                      9

<PAGE>   10





6.      The Company agrees with Goldman, Sachs & Co.:

        (a) To prepare the Secondary Transactions Prospectus in a form approved
by Goldman, Sachs & Co. and to file such Prospectus pursuant to Rule 424(b)
under the Act not later than the Commission's close of business on the second
business day following the execution and delivery of this Agreement, or, if
applicable, such earlier time as may be required by Rule 430A(a)(3) under the
Act; to make no further amendment or any supplement to the Registration
Statement or the Secondary Transactions Prospectus during the Secondary
Transactions Period (as defined below) which shall be disapproved by Goldman,
Sachs & Co. promptly after reasonable notice thereof (it being understood that,
when Form S-2 or S-3 under the Act is available to the Company, the Company may
amend the Registration Statement so as to be on such form, or may file a new
registration statement on such form (in which case any reference herein to the
Registration Statement or the Prospectus shall include such new registration
and the prospectus contained therein in the form first filed pursuant to Rule
424(b) under the Act, respectively), and thereafter any information required to
be included in the Registration Statement or the Secondary Transactions
Prospectus may be incorporated therein by reference as permitted by such form);
to advise Goldman, Sachs & Co., promptly after the Company receives notice
thereof, of the time when the Registration Statement, or any amendment thereto,
has been filed or becomes effective during the Secondary Transactions Period,
or any supplement to the Secondary Transactions Prospectus or any amended
Secondary Transactions Prospectus has been filed during such period, and to
furnish Goldman, Sachs & Co. with copies thereof; to advise Goldman, Sachs &
Co., promptly after the Company receives notice thereof during the Secondary
Transactions Period, of the issuance by the Commission of any stop order or of
any order preventing or suspending the use of any Preliminary Prospectus or
Prospectus, of the suspension of the qualification of the Shares for offering
or sale in any jurisdiction, of the initiation or threatening of any proceeding
for any such purpose, or of any request by the Commission for the amending or
supplementing of the Registration Statement or Prospectus or for additional
information; and, in the event of the issuance of any stop order or of any
order preventing or suspending the use of any Preliminary Prospectus or
Prospectus or suspending any such qualification during the Secondary
Transactions Period, to use promptly its reasonable efforts to obtain the
withdrawal of such order (the period beginning on the date hereof and
continuing for as long as may be required under applicable law, in the
reasonable judgment of Goldman, Sachs & Co. after consultation with the
Company, in order to offer and sell Stock as contemplated by the Secondary
Transactions Prospectus, is herein called the "Secondary Transactions Period");

        (b) Promptly from time to time to take such action as Goldman, Sachs & 
Co. may reasonably request to qualify the Shares for offering and sale during
the Secondary Transactions Period under the securities laws of such
jurisdictions as Goldman, Sachs & Co. may request and to comply with such laws
so as to permit the continuance of sales and dealings therein in such
jurisdictions during such period, provided that in connection therewith the
Company shall not be required to qualify as a foreign corporation or to file a
general consent to service of process in any jurisdiction;

        (c) Prior to 10:00 a.m., New York City time, on the New York Business 
Day next succeeding the date of this Agreement and from time to time during the
Secondary Transactions Period, to furnish Goldman, Sachs & Co. with copies of
the Secondary 


                                       10




<PAGE>   11




         Transactions Prospectus in such quantities as Goldman, Sachs &
         Co. may reasonably request, and, if at any time during such period any
         event shall have occurred as a result of which the Secondary
         Transactions Prospectus as then amended or supplemented would include
         an untrue statement of a material fact or omit to state any material
         fact necessary in order to make the statements therein, in the light
         of the circumstances under which they were made when such Prospectus
         is to be delivered during such period, not misleading, or, if for any
         other reason it shall be necessary during such period to amend or
         supplement the Secondary Transactions Prospectus or to amend the
         Registration Statement in order to comply with the Act or to file
         under the 1934 Act any document incorporated by reference in such
         Prospectus in order to comply with the Act or the 1934 Act, to notify
         Goldman, Sachs & Co. and upon its request to file such document and to
         prepare and furnish without charge to Goldman, Sachs & Co. as many
         copies as it may from time to time during such period reasonably
         request of an amended Secondary Transactions Prospectus or a
         supplement to the Secondary Transactions Prospectus which will correct
         such statement or omission or effect such compliance;

                (d) During the Secondary Transactions Period, to furnish to
         Goldman, Sachs & Co. copies of all reports or other communications
         (financial or other) furnished to stockholders generally, and to
         deliver to Goldman, Sachs & Co. (i) as soon as they are available,
         copies of any reports and financial statements furnished to or filed
         with the Commission or any inter-dealer quotation system or any
         national securities exchange on which any class of securities of the
         Company is listed; and (ii) such additional information concerning the
         business and financial condition of the Company as Goldman, Sachs &
         Co. may from time to time reasonably request (such financial
         statements to be on a consolidated basis to the extent the accounts of
         the Company and its subsidiaries are consolidated in reports furnished
         to its stockholders generally or to the Commission); and

                (e) To use its reasonable efforts to furnish or cause to be
         furnished to Goldman, Sachs & Co. upon its request at reasonable
         intervals, when the Registration Statement or the Secondary
         Transactions Prospectus shall be amended or supplemented during the
         Secondary Transactions Period, written opinions of counsel for the
         Company, a letter from the independent accountants who have certified
         the financial statements included in the Registration Statement as
         then amended and certificates of officers of the Company, in each case
         in form and substance reasonably satisfactory to you, all to the
         effect specified in subsections (c), (d), (e), (f), (g) and (l),
         respectively, of Section 8 hereof (as modified to relate to the
         Registration Statement and the Secondary Transactions Prospectus as
         then amended or supplemented).

         Notwithstanding the foregoing provisions, if at any time the Company
determines in the exercise of its reasonable judgment that it is in possession
of material, non-public information that it would not be required to disclose
publicly in the absence of a registration of Stock under the Act, the Company
may, upon notice to Goldman, Sachs & Co., cease to comply with any of its
obligations under this Section 6, but only for a period or periods that the
Company reasonably determines are necessary in order to avoid such premature
disclosure and in any event not to exceed 90 days in the aggregate during any
period of 12 consecutive calendar months.  Upon receipt of any such notice,
Goldman, Sachs & Co. shall cease using the Secondary Transactions Prospectus or
any amendment or supplement thereto until it receives notice from the Company
that it may resume using such document.

                                       11



<PAGE>   12





        7. The Company covenants and agrees with the several Underwriters that 
the Company will pay or cause to be paid the following: (i) the fees,
disbursements and expenses of the Company's counsel and accountants in
connection with the registration of the Shares under the Act and all other
expenses in connection with the preparation, printing and filing of the
Registration Statement, any Preliminary Prospectus and the Prospectus and
amendments and supplements thereto and the mailing and delivering of copies
thereof to the Underwriters and dealers; (ii) the cost of printing or producing
any Agreement among Underwriters, this Agreement, the Blue Sky Memorandum and
closing documents (including any compilations thereof) for the sale of the
Shares by the Underwriters pursuant to the Public Offering Prospectus and any
other documents in connection with the offering, purchase, sale and delivery of
the Shares; (iii) all expenses in connection with the qualification of the
Shares for offering and sale under state securities laws as provided in Section
5(b) hereof, including the fees and disbursements of counsel for the
Underwriters, and counsel for Goldman, Sachs & Co. during the Secondary
Transactions Period, in connection with such qualification and in connection
with the Blue Sky survey; (iv) all fees and expenses in connection with listing
the Shares on the NASDAQ; (v) the filing fees incident to, and the fees and
disbursements of counsel for the Underwriters in connection with, securing any
required review by the National Association of Securities Dealers, Inc. of the
terms of the sale of the Shares by the Underwriters pursuant to the Public
Offering Prospectus; (vi) the cost of preparing stock certificates; (vii) the
cost and charges of any transfer agent or registrar; (viii) all reasonable
fees, disbursements and expenses incurred pursuant to Section 6(e) hereof; and
(ix) all other costs and expenses incident to the performance of its
obligations hereunder which are not otherwise specifically provided for in this
Section. It is understood, however, that, except as provided in this Section,
and Sections 9 and 12 hereof, the Underwriters will pay all of their own costs
and expenses, including the fees of their counsel, stock transfer taxes on
resale of any of the Shares by them, and any advertising expenses connected
with any offers they may make.

        8. The obligations of the Underwriters hereunder, as to the Shares to be
delivered at each Time of Delivery, shall be subject, in their discretion, to
the condition that all representations and warranties and other statements of
the Company herein are, at and as of such Time of Delivery, true and correct,
the condition that the Company shall have performed all of its obligations
hereunder theretofore to be performed, and the following additional conditions:

          (a) The Prospectus shall have been filed with the Commission pursuant
     to Rule 424(b) within the applicable time period prescribed for such
     filing by the rules and regulations under the Act and in accordance with
     Section 5(a) hereof; if the Company has elected to rely upon Rule 462(b),
     the Rule 462(b) Registration Statement shall have become effective by
     10:00 P.M., Washington, D.C. time, on the date of this Agreement; no stop
     order suspending the effectiveness of the Registration Statement or any
     part thereof shall have been issued and no proceeding for that purpose
     shall have been initiated or threatened by the Commission; and all
     requests for additional information on the part of the Commission shall
     have been complied with to your reasonable satisfaction;

          (b) Fried, Frank, Harris, Shriver & Jacobson, counsel for the
     Underwriters, shall have furnished to you such opinion or opinions (a
     draft of such opinion is attached as Annex II(a) hereto) dated such Time
     of Delivery, with respect to the incorporation of the Company, the
     validity of the Shares being delivered at such Time of Delivery, the
     Registration Statement, the Prospectus and such other related matters as
     you may reasonably request, and such counsel


                                       12



<PAGE>   13




     shall have received such papers and information as they may reasonably 
     request to enable them to pass upon such matters;

          (c) Robinson, Bradshaw & Hinson, P.A., counsel for the Company, shall
     have furnished to you their written opinion (a draft of such opinion is
     attached as Annex II(b) hereto), dated such Time of Delivery, in form and
     substance satisfactory to you, to the effect that:

                  (i) The Company has been duly incorporated and is validly
             existing as a corporation in good standing under the laws of the
             State of Delaware, with power and authority (corporate and other)
             to own its properties and conduct its business as described in the
             Prospectus;

                  (ii) The Company has an authorized capitalization as set
             forth in the Prospectus, and all of the issued shares of capital
             stock of the Company have been duly and validly authorized and
             issued and are fully paid and non-assessable, and all of the
             Shares have been duly and validly authorized and, when issued and
             delivered against payment therefor as provided in this Agreement,
             will be duly and validly issued and fully paid and non-assessable;
             and the Shares conform to the description of the Stock contained
             in the Prospectus;

                  (iii) The Company has been duly qualified as a foreign
             corporation for the transaction of business and is in good
             standing under the laws of each jurisdiction in which it owns or
             leases properties or conducts any business so as to require such
             qualification or is subject to no material liability or disability
             by reason of failure to be so qualified in any such jurisdiction
             (such counsel being entitled to rely in respect of the opinion in
             this clause upon opinions of local counsel and in respect of
             matters of fact upon certificates of officers of the Company,
             provided that such counsel shall state that they believe that both
             you and they are justified in relying upon such opinions and
             certificates);

                  (iv) Each subsidiary of the Company is listed on Annex A to
             such opinion (such counsel being entitled to rely in respect of
             the opinion in the foregoing clause upon certificates of officers
             of the Company or its subsidiaries provided that such counsel
             shall state that they believe that both you and they are justified
             in relying upon such certificates) and each United States
             subsidiary has been duly incorporated and is validly existing as a
             corporation in good standing under the laws of its jurisdiction of
             incorporation; and all of the issued shares of capital stock of
             each such subsidiary have been duly and validly authorized and
             issued, are fully paid and non-assessable, and (except for
             directors' qualifying shares) are owned directly or indirectly by
             the Company, free and clear of all liens, encumbrances, equities
             or claims (such counsel being entitled to rely in respect of the
             opinion in this clause upon opinions of local counsel and in
             respect to matters of fact upon certificates of officers of the
             Company or its subsidiaries, provided that such counsel shall
             state that they believe that both you and they are justified in
             relying upon such opinions and certificates);

                  (v) To the best of such counsel's knowledge and other than as
             set forth in the Prospectus, there are no legal or governmental
             proceedings pending to which the Company or any of its subsidiaries
             is a party or of which any property of the Company or any of its
             subsidiaries is the subject which, if determined 


                                     13

<PAGE>   14




             adversely to the Company or any of its subsidiaries, would 
             individually or in the aggregate have a material adverse effect 
             on the current or future consolidated financial position, 
             stockholders' equity or results of operations of the Company and 
             its subsidiaries; and, to the best of such counsel's knowledge, 
             no such proceedings are threatened or contemplated by governmental
             authorities or threatened by others;

                  (vi) This Agreement has been duly authorized, executed and
             delivered by the Company;

                  (vii) The issue and sale of the Shares being delivered at
             such Time of Delivery by the Company and the compliance by the
             Company with all of the provisions of this Agreement and
             the consummation of the transactions herein contemplated will not
             (1) conflict with or result in a breach or violation of any of the
             terms or provisions of, or constitute a default under, any
             indenture, mortgage, deed of trust, loan agreement, lease,
             judgment or other agreement or instrument listed on Annex B to
             such opinion or of the provisions of the Certificate of
             Incorporation or By-laws of the Company or (2) violate any federal
             law of the United States, any law of the State of North Carolina
             or the Delaware General Corporation Law applicable to the Company
             or any order known to such counsel of any court or governmental
             agency or body having jurisdiction over the Company or any of its
             subsidiaries or any of their properties; provided, however, that,
             for the purpose of this clause (2), such counsel need not express
             an opinion with respect to state securities laws and federal
             securities laws, to the extent such federal securities laws are
             covered in the opinion in subsection (xi) hereof;

                  (viii) No consent, approval, authorization, order,
             registration or qualification of or with any such court or
             governmental agency or body is required for the issue and sale of
             the Shares or the consummation by the Company of the transactions
             contemplated by this Agreement, except the registration under the
             Act of the Shares, registration of the Stock under the 1934 Act
             and such consents, approvals, authorizations, registrations or
             qualifications as may be required under state securities or Blue
             Sky laws in connection with the purchase and distribution of the
             Shares by the Underwriters;

                  (ix) The statements set forth in the Prospectus under the
             caption "Description of Capital Stock", insofar as they purport to
             constitute a summary of the terms of the Stock, and under the 
             caption "Underwriting", insofar as they purport to describe the 
             provisions of the laws and documents referred to therein, are 
             accurate, complete and fair;

                  (x) The Company is not an "investment company" or an entity
             "controlled" by an "investment company", as such terms are defined
             in the Investment Company Act; and

                  (xi) The Registration Statement, as of its effective date,
             and the Prospectus and any further amendments and supplements
             thereto made by the Company prior to such Time of Delivery, as of
             the date thereof, (other than the financial statements and related
             schedules or other financial information therein, as to which such
             counsel need express no opinion) appear on their face to be
             appropriately 

                                       14

<PAGE>   15



             responsive in all material respects to the requirements of the
             Act and the rules and regulations thereunder; although they do
             not assume any responsibility for the accuracy, completeness or
             fairness of the statements contained in the Registration
             Statement or the Prospectus, except for those referred to in the
             opinion in subsection (ix) of this section 8(c), nothing has come
             to their attention that has caused them to believe that, as of
             its effective date, the Registration Statement or any further
             amendment thereto made by the Company prior to such Time of
             Delivery (other than the financial statements and related
             schedules or other financial information therein, as to which such
             counsel need express no opinion) contained an untrue statement of
             a material fact or omitted to state a material fact required to be
             stated therein or necessary to make the statements therein not
             misleading or that, as of its date, the Prospectus or any further
             amendment or supplement thereto made by the Company prior to such
             Time of Delivery (other than the financial statements and related
             schedules or other financial information therein, as to which such
             counsel need express no opinion) contained an untrue statement of
             a material fact or omitted to state a material fact necessary to
             make the statements therein, in the light of the circumstances
             under which they were made, not misleading or that, as of such
             Time of Delivery, either the Registration Statement or the
             Prospectus or any further amendment or supplement thereto made by
             the Company prior to such Time of Delivery (other than the
             financial statements and related schedules or other financial
             information therein, as to which such counsel need express no
             opinion) contains an untrue statement of a material fact or omits
             to state a material fact necessary to make the statements therein,
             in the light of the circumstances under which they were made, not
             misleading; and they do not know of any amendment the
             Registration Statement required to be filed or of any contracts
             or other documents of a character required to be filed as an
             exhibit to the Registration Statement or required to be described
             in the Registration Statement or the Prospectus which are not
             filed or described as required;

          (d) R. Forrest Waldon, Vice President and General Counsel of the
     Company, shall have furnished to you his written opinion (a draft of such
     opinion is attached as Annex II(c) hereto), dated such Time of Delivery,
     in form and substance satisfactory to you, to the effect that:

                  (i) The issue and sale of the Shares being delivered at such
             Time of Delivery by the Company and the compliance by the Company
             with all of the provisions of this Agreement and the consummation
             of the transactions herein contemplated will not conflict with or
             result in a breach or violation of any of the terms or provisions
             of, or constitute a default under, any indenture, mortgage, deed
             of trust, loan agreement, lease, judgment or other agreement or
             instrument known to such counsel to which the Company or any of
             its subsidiaries is a party or by which the Company or any of its
             subsidiaries is bound or to which any of the property or assets of
             the Company or any of its subsidiaries is subject, nor will such
             action result in any violation of the provisions of the
             Certificate of Incorporation or By-laws of the Company or any
             statute or any order, rule or regulation known to such counsel of
             any court or governmental agency or body having jurisdiction over
             the Company or any of its subsidiaries or any of their properties;

                                     15
<PAGE>   16


                  (ii) The Company and its subsidiaries have good and
             marketable title in fee simple to all real property owned by them,
             in each case free and clear of all liens, encumbrances and defects
             except such as are described in the Prospectus or such as do not
             materially affect the value of such property and do not interfere
             with the use made and proposed to be made of such property by the
             Company and its subsidiaries; and any real property and buildings
             held under lease by the Company and its subsidiaries are held by
             them under valid, subsisting and enforceable leases with such
             exceptions as are not material and do not interfere with the use
             made and proposed to be made of such property and buildings by the
             Company and its subsidiaries (in giving the opinion in this
             clause, such counsel may state that he is relying upon a general
             review of the titles of the Company and its subsidiaries, upon
             opinions of local counsel and abstracts, reports and policies of
             title companies rendered or issued at or subsequent to the time of
             acquisition of such property by the Company or its subsidiaries,
             upon opinions of counsel to the lessors of such property and, in
             respect to matters of fact, upon certificates of officers of the
             Company or its subsidiaries, provided that such counsel shall
             state that he believes that both you and he are justified in
             relying upon such opinions, abstracts, reports, policies and
             certificates);

                  (iii) Neither the Company nor any of its subsidiaries is in
             violation of its Certificate of Incorporation or, to his knowledge
             after due inquiry, By-laws or in default in the performance or
             observance of any obligation, agreement, covenant or condition
             contained in any indenture, mortgage, deed of trust, loan
             agreement, lease, judgment or other agreement or instrument to
             which it is a party or by which it or any of its properties may be
             bound, except where such a default would not, individually or in
             the aggregate, have a material adverse effect on the current or
             future consolidated financial position, business prospects,
             stockholders' equity or results of operations of the Company and
             its subsidiaries; and

                  (iv) Although he does not assume any responsibility for the
             accuracy, completeness or fairness of the statements contained in
             the Registration Statement or the Prospectus, nothing has come to
             his attention that has caused him to believe that, as of its
             effective date, the Registration Statement or any further
             amendment thereto made by the Company prior to such Time of
             Delivery (other than the financial statements and related
             schedules or other financial information therein, as to which
             such counsel need express no opinion) contained an untrue
             statement of a material fact or omitted to state a material fact
             required to be stated therein or necessary to make the statements
             therein not misleading or that, as of its date, the Prospectus or
             any further amendment or supplement thereto made by the Company
             prior to such Time of Delivery (other than the financial
             statements and related schedules or other financial information
             therein, as to which such counsel need express no opinion)
             contained an untrue statement of a material fact or omitted to
             state a material fact necessary to make the statements therein, in
             the light of the circumstances under which they were made, not     
             misleading or that, as of such Time of Delivery, either the
             Registration Statement or the Prospectus or any further amendment
             or supplement thereto made by the Company prior to such Time of
             Delivery (other than the financial statements and related
             schedules or other financial information therein, as to which 


                                     16
<PAGE>   17


             such counsel need express no opinion) contains an untrue
             statement of a material fact or omits to state a material fact
             necessary to make the statements therein, in the light of the
             circumstances under which they were made, not misleading; and he
             does not know of any amendment to the Registration Statement
             required to be filed or of any contracts or other documents of a
             character required to be filed as an exhibit to the Registration
             Statement or required to be described in the Registration
             Statement or the Prospectus which are not filed or described as
             required;

          (e) On the date of the Public Offering Prospectus at a time prior to
     the execution of this Agreement, at 9:30 a.m., New York City time, on the
     effective date of any post-effective amendment to the Registration
     Statement filed subsequent to the date of this Agreement and during the
     Public Offering Period and also at each Time of Delivery, Price
     Waterhouse, LLP shall have furnished to you a letter or letters, dated the
     respective dates of delivery thereof, in form and substance satisfactory
     to you, to the effect set forth in Annex I hereto (the executed copy of
     the letter delivered prior to the execution of this Agreement is attached
     as Annex I(a) hereto and a draft of the form of letter to be delivered on
     the effective date of any post-effective amendment to the Registration
     Statement and as of each Time of Delivery is attached as Annex I(b)
     hereto);

          (f) On the date of the Public Offering Prospectus at a time prior to
     the execution of this Agreement, at 9:30 a.m., New York City time, on the
     effective date of any post-effective amendment to the Registration
     Statement filed subsequent to the date of this Agreement and during the
     Public Offering Period and also at each Time of Delivery, McGladrey &
     Pullen, LLP shall have furnished to you a letter or letters, dated the
     respective dates of delivery thereof, in form and substance satisfactory
     to you, to the effect set forth in Annex I(c) hereto;

          (g) (i) Neither the Company nor any of its subsidiaries shall have
     sustained since the date of the latest audited financial statements
     included in the Prospectus any loss or interference with its business from
     fire, explosion, flood or other calamity, whether or not covered by
     insurance, or from any labor dispute or court or governmental action,
     order or decree, otherwise than as set forth or contemplated in the
     Prospectus, and (ii) since the respective dates as of which information is
     given in the Prospectus there shall not have been any change in the
     capital stock or any increase in excess of $250,000 in the long-term debt
     of the Company or any of its subsidiaries or any change, or any
     development involving a prospective change, in or affecting the general
     affairs, management, financial position, stockholders' equity or results
     of operations of the Company and its subsidiaries, otherwise than as set
     forth or contemplated in the Prospectus, the effect of which, in any such
     case described in Clause (i) or (ii), is in the judgment of the
     Representatives so material and adverse as to make it impracticable or
     inadvisable to proceed with the public offering or the delivery of the
     Shares being delivered at such Time of Delivery on the terms and in the
     manner contemplated in the Prospectus;

          (h) On or after the date hereof there shall not have occurred any of
     the following: (i) a suspension or material limitation in trading in
     securities generally on the New York Stock Exchange or on NASDAQ; (ii) a
     suspension or material limitation in trading in the Company's securities   
     on NASDAQ; (iii) a general moratorium on commercial banking activities
     declared by either Federal or New York State authorities; or (iv) the
     outbreak or escalation of hostilities involving the United States or the
     declaration by the United States of a national emergency or

                                     17
<PAGE>   18
 

     war, if the effect of any such event specified in this Clause (iv)
     in the judgment of the Representatives makes it impracticable or
     inadvisable to proceed with the public offering or the delivery of the
     Shares being delivered at such Time of Delivery on the terms and in the
     manner contemplated in the Prospectus;

          (i) The Shares to be sold at such Time of Delivery shall have been
     duly approved for quotation on NASDAQ;

          (j) The Company has obtained and delivered to the Underwriters
     executed copies of an agreement from each of the Stockholders named in
     Schedule II hereto, substantially to the effect set forth in Section 5(e)
     hereof in form and substance satisfactory to you;

          (k) The Company shall have complied with the provisions of Section
     5(c) hereof with respect to the furnishing of prospectuses on the New York
     Business Day next succeeding the date of this Agreement; and

          (l) The Company shall have furnished or caused to be furnished to you
     at such Time of Delivery certificates of officers of the Company
     satisfactory to you as to the accuracy of the representations and
     warranties of the Company herein at and as of such Time of Delivery, as to
     the performance by the Company of all of its obligations hereunder to be
     performed at or prior to such Time of Delivery, as to the matters set
     forth in subsections (a) and (g) of this Section and as to such other
     matters as you may reasonably request.

          9. (a) The Company will indemnify and hold harmless each Underwriter
     against any losses, claims, damages or liabilities, joint or several, to
     which such Underwriter may become subject, under the Act or otherwise,
     insofar as such losses, claims, damages or liabilities (or actions in
     respect thereof) arise out of or are based upon an untrue statement or
     alleged untrue statement of a material fact contained in any Preliminary
     Prospectus, the Registration Statement or the Prospectus, or any amendment
     or supplement thereto, or arise out of or are based upon the omission or
     alleged omission to state therein a material fact required to be stated
     therein or necessary to make the statements therein not misleading, and
     will reimburse each Underwriter for any legal or other expenses reasonably
     incurred by such Underwriter in connection with investigating or defending
     any such action or claim as such expenses are incurred; provided, however,
     that the Company shall not be liable in any such case to the extent that
     any such loss, claim, damage or liability arises out of or is based upon
     an untrue statement or alleged untrue statement or omission or alleged
     omission made in any Preliminary Prospectus, the Registration Statement or
     the Prospectus or any such amendment or supplement in reliance upon and in
     conformity with written information furnished to the Company by any
     Underwriter through Goldman, Sachs & Co. expressly for use therein.

          (b) Each Underwriter will indemnify and hold harmless the Company
     against any losses, claims, damages or liabilities to which the Company
     may become subject, under the Act or otherwise, insofar as such losses,
     claims, damages or liabilities (or actions in respect thereof) arise out
     of or are based upon an untrue statement or alleged untrue statement of a
     material fact contained in any Preliminary Prospectus, the Registration
     Statement or the Prospectus, or any amendment or supplement thereto, or
     arise out of or are based upon the omission or alleged omission to state
     therein a material fact required to be stated therein or necessary to make
     the statements therein not misleading, in each case to the extent, but
     only to the extent,

                                     18
<PAGE>   19
 

     that such untrue statement or alleged untrue statement or omission or
     alleged omission was made in any Preliminary Prospectus, the Registration
     Statement or the Prospectus or any such amendment or supplement in
     reliance upon and in conformity with written information furnished to the
     Company by such Underwriter through Goldman, Sachs & Co. expressly for use
     therein; and will reimburse the Company for any legal or other expenses
     reasonably incurred by the Company in connection with investigating or
     defending any such action or claim as such expenses are incurred.
     
          (c) Promptly after receipt by an indemnified party under subsection
     (a) or (b) above of notice of the commencement of any action, such
     indemnified party shall, if a claim in respect thereof is to be made
     against the indemnifying party under such subsection, notify the
     indemnifying party in writing of the commencement thereof; but the
     omission so to notify the indemnifying party shall not relieve it from any
     liability which it may have to any indemnified party otherwise than under
     such subsection.  In case any such action shall be brought against any
     indemnified party and it shall notify the indemnifying party of the
     commencement thereof, the indemnifying party shall be entitled to
     participate therein and, to the extent that it shall wish, jointly with
     any other indemnifying party similarly notified, to assume the defense
     thereof, with counsel satisfactory to such indemnified party (who shall
     not, except with the consent of the indemnified party, be counsel to the
     indemnifying party), and, after notice from the indemnifying party to such
     indemnified party of its election so to assume the defense thereof, the
     indemnifying party shall not be liable to such indemnified party under
     such subsection for any legal expenses of other counsel or any other
     expenses, in each case subsequently incurred by such indemnified party, in
     connection with the defense thereof other than reasonable costs of
     investigation.  No indemnifying party shall, in connection with any one
     action or claim, or separate but substantially similar actions or claims
     arising out of the same general allegations, be liable for the fees and
     expenses of more than one separate firm of attorneys at any time for all
     indemnified parties, except to the extent that local counsel, in addition
     to regular counsel, is required in order to defend effectively against
     such action or claim.  No indemnifying party shall, without the written
     consent of the indemnified party, effect the settlement or compromise of,
     or consent to the entry of any judgment with respect to, any pending or
     threatened action or claim in respect of which indemnification or
     contribution may be sought hereunder (whether or not the indemnified party
     is an actual or potential party to such action or claim) unless such
     settlement, compromise or judgment (i) includes an unconditional release
     of the indemnified party from all liability arising out of such action or
     claim and (ii) does not include a statement as to or an admission of
     fault, culpability or a failure to act, by or on behalf of any indemnified
     party.

          (d) If the indemnification provided for in this Section 9 is
     unavailable to or insufficient to hold harmless an indemnified party under
     subsection (a) or (b) above in respect of any losses, claims, damages or
     liabilities (or actions in respect thereof) referred to therein, then each
     indemnifying party shall contribute to the amount paid or payable by such
     indemnified party as a result of such losses, claims, damages or
     liabilities (or actions in respect thereof) in such proportion as is
     appropriate to reflect the relative benefits received by the Company on
     the one hand and the Underwriters on the other from the offering of the
     Shares.  If, however, the allocation provided by the immediately preceding
     sentence is not permitted by applicable law or if the indemnified party
     failed to give the notice required under subsection (c) above, then each
     indemnifying party shall contribute to such amount paid or payable by such
     indemnified


                                     19
<PAGE>   20
 

     party in such proportion as is appropriate to reflect not only such
     relative benefits but also the relative fault of the Company on the one
     hand and the Underwriters on the other in connection with the statements
     or omissions which resulted in such losses, claims, damages or liabilities
     (or actions in respect thereof), as well as any other relevant equitable
     considerations.  The relative benefits received by the Company on the one
     hand and the Underwriters on the other shall be deemed to be in the same
     proportion as the total net proceeds from the sale of the Shares (before
     deducting expenses) received by the Company in the underwritten public
     offering bear to the total underwriting discounts and commissions received
     by the Underwriters with respect to the Shares purchased in the
     underwritten public offering, in each case as set forth in the table on
     the cover page of the Public Offering Prospectus.  The relative fault
     shall be determined by reference to, among other things, whether the
     untrue or alleged untrue statement of a material fact or the omission or
     alleged omission to state a material fact relates to information supplied
     by the Company on the one hand or the Underwriters on the other and the
     parties' relative intent, knowledge, access to information and opportunity
     to correct or prevent such statement or omission.  The Company and the
     Underwriters agree that it would not be just and equitable if
     contributions pursuant to this subsection (d) were determined by pro rata
     allocation (even if the Underwriters were treated as one entity for such   
     purpose) or by any other method of allocation which  does not take account
     of the equitable considerations referred to above in this subsection (d). 
     The amount paid or payable by an indemnified party as a result of the
     losses, claims, damages or liabilities (or actions in respect thereof)
     referred to above in this subsection (d) shall be deemed to include any
     legal or other expenses reasonably incurred by such indemnified party in
     connection with investigating or defending any such action or claim. 
     Notwithstanding the provisions of this subsection (d), no Underwriter
     shall be required to contribute any amount in excess of the amount by
     which the total price at which the Shares underwritten by it and
     distributed to the public were offered to the public exceeds the amount of
     any damages which such Underwriter has otherwise been required to pay by
     reason of such untrue or alleged untrue statement or omission or alleged
     omission.  No person guilty of fraudulent misrepresentation (within the
     meaning of Section 11(f) of the Act) shall be entitled to contribution
     from any person who was not guilty of such fraudulent misrepresentation.
     The Underwriters' obligations in this subsection (d) to contribute are
     several in proportion to their respective underwriting obligations and not
     joint.

          (e) The obligations of the Company under this Section 9 shall be in
     addition to any liability which the Company may otherwise have and shall
     extend, upon the same terms and conditions, to each person, if any, who
     controls any Underwriter within the meaning of the Act; and the
     obligations of the Underwriters under this Section 9 shall be in addition
     to any liability which the respective Underwriters may otherwise have and
     shall extend, upon the same terms and conditions, to each officer and
     director of the Company and to each person, if any, who controls the
     Company within the meaning of the Act.

          10. (a)  If any Underwriter shall default in its obligation to
     purchase the Shares which it has agreed to purchase hereunder at a Time of
     Delivery, you may in your discretion arrange for you or another party or
     other parties to purchase such Shares on the terms contained herein.  If
     within thirty-six hours after such default by any Underwriter you do not
     arrange for the purchase of such Shares, then the Company shall be
     entitled to a further period of thirty-six hours within which to procure
     another party or other parties satisfactory to you to


                                     20
<PAGE>   21
 

     purchase such Shares on such terms.  In the event that, within the
     respective prescribed periods, you notify the Company that you have so
     arranged for the purchase of such Shares, or the Company notifies you that
     it has so arranged for the purchase of such Shares, you or the Company
     shall have the right to postpone such Time of Delivery for a period of not
     more than seven days, in order to effect whatever changes may thereby be
     made necessary in the Registration Statement or the Prospectus, or in any
     other documents or arrangements, and the Company agrees to file promptly
     any amendments to the Registration Statement or the Prospectus which in
     your opinion may thereby be made necessary. The term "Underwriter" as used
     in this Agreement shall include any person substituted under this Section
     with like effect as if such person had originally been a party to this
     Agreement with respect to such Shares.

          (b) If, after giving effect to any arrangements for the purchase of
     the Shares of a defaulting Underwriter or Underwriters by you and the
     Company as provided in subsection (a) above, the aggregate number of such
     Shares which remains unpurchased does not exceed one-eleventh of the
     aggregate number of all the Shares to be purchased at such Time of
     Delivery, then the Company shall have the right to require each
     non-defaulting Underwriter to purchase the number of shares which such
     Underwriter agreed to purchase hereunder at such Time of Delivery and, in
     addition, to require each non-defaulting Underwriter to purchase its pro
     rata share (based on the number of Shares which such Underwriter agreed to
     purchase hereunder) of the Shares of such defaulting Underwriter or
     Underwriters for which such arrangements have not been made; but nothing
     herein shall relieve a defaulting Underwriter from liability for its
     default.

          (c) If, after giving effect to any arrangements for the purchase of   
     the Shares of a defaulting Underwriter or Underwriters by you and the
     Company as provided in subsection (a) above, the aggregate number of such
     Shares which remains unpurchased exceeds one-eleventh of the aggregate
     number of all the Shares to be purchased at such Time of Delivery, or if
     the Company shall not exercise the right described in subsection (b) above
     to require non-defaulting Underwriters to purchase Shares of       a
     defaulting Underwriter or Underwriters, then this Agreement (or, with
     respect to the Second Time of Delivery, the obligations of the
     Underwriters to purchase and of the Company to sell the Optional Shares)
     shall thereupon terminate, without liability on the part of any
     non-defaulting Underwriter or the Company, except for the expenses to be
     borne by the Company and the Underwriters as provided in Section 7 hereof
     and the indemnity and contribution agreements in Section 9 hereof; but
     nothing herein shall relieve a defaulting Underwriter from liability for
     its default.

     11. The respective indemnities, agreements, representations, warranties
and other statements of the Company and the several Underwriters, as set forth
in this Agreement or made by or on behalf of them, respectively, pursuant to
this Agreement, shall remain in full force and effect, regardless of any
investigation (or any statement as to the results thereof) made by or on behalf
of any Underwriter or any controlling person of any Underwriter, or the
Company, or any officer or director or controlling person of the Company, and
shall survive delivery of and payment for the Shares.

     Anything herein to the contrary notwithstanding, the indemnity agreement
of the Company in subsection (a) of Section 9 hereof, the representations and
warranties in subsections (b) and (c) of Section 1 hereof and any
representation or warranty as to the accuracy of the Registration Statement or
the Prospectus contained in any certificate furnished by the Company pursuant
to Section 8


                                     21
<PAGE>   22
 

hereof, insofar as they may constitute a basis for indemnification for
liabilities (other than payment by the Company of expenses incurred or paid in
the successful defense of any action, suit or proceeding) arising under the
Act, shall not extend to the extent of any interest therein of a controlling
person or partner of an Underwriter who is a director, officer or controlling
person of the Company when the Registration Statement has become effective,
except in each case to the extent that an interest of such character shall have
been determined by a court of appropriate jurisdiction as not against public
policy as expressed in the Act.  Unless in the opinion of counsel for the
Company the matter has been settled by controlling precedent, the Company will,
if a claim for such indemnification is asserted, submit to a court of
appropriate jurisdiction the question of whether such interest is against
public policy as expressed in the Act and will be governed by the final
adjudication of such issue.

     12. If this Agreement shall be terminated pursuant to Section 10 hereof,
the Company shall not then be under any liability to any Underwriter except as
provided in Sections 7 and 9 hereof; but, if for any other reason, any Shares
are not delivered by or on behalf of the Company as provided herein, the
Company will reimburse the Underwriters through you for all out-of-pocket
expenses approved in writing by you, including fees and disbursements of
counsel, reasonably incurred by the Underwriters in making preparations for the
purchase, sale and delivery of the Shares not so delivered, but the Company
shall then be under no further liability to any Underwriter except as provided
in Sections 7 and 9 hereof.

     13. In all dealings hereunder, you shall act on behalf of each of the
Underwriters, and the parties hereto shall be entitled to act and rely upon any
statement, request, notice or agreement on behalf of any Underwriter made or
given by you jointly or by Goldman, Sachs & Co. on behalf of you as the
representatives.

     All statements, requests, notices and agreements hereunder shall be in
writing, and if to the Underwriters shall be delivered or sent by mail, telex
or facsimile transmission to you as the representatives in care of Goldman,
Sachs & Co., 85 Broad Street, New York, New York  10004, Attention:
Registration Department; and if to the Company shall be delivered or sent by
mail to the address of the Company set forth in the Registration Statement,
Attention: Secretary; provided, however, that any notice to an Underwriter
pursuant to Section 9(c) hereof shall be delivered or sent by mail, telex or
facsimile transmission to such Underwriter at its address set forth in its
Underwriters' Questionnaire, or telex constituting such Questionnaire, which
address will be supplied to the Company by you upon request.  Any such
statements, requests, notices or agreements shall take effect upon receipt
thereof.

     14. This Agreement shall be binding upon, and inure solely to the benefit
of, the Underwriters, the Company and, to the extent provided in Sections 9
and 11 hereof, the officers and directors of the Company and each person who
controls the Company or any Underwriter, and their respective heirs, executors,
administrators, successors and assigns, and no other person shall acquire or    
have any right under or by virtue of this Agreement. No purchaser of any of the
Shares from any Underwriter shall be deemed a successor or assign by reason
merely of such purchase.

     15. Time shall be of the essence of this Agreement.  As used herein, the
term "business day" shall mean any day when the Commission's office in
Washington, D.C.  is open for business.

     16. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH
THE LAWS OF THE STATE OF NEW YORK.


                                     22
<PAGE>   23
 

     17. This Agreement may be executed by any one or more of the parties
hereto in any number of counterparts, each of which shall be deemed to be an
original, but all such counterparts shall together constitute one and the same
instrument.

     If the foregoing is in accordance with your understanding, please sign and
return to us six counterparts hereof, and upon the acceptance hereof by you, on
behalf of each of the Underwriters, this letter and such acceptance hereof
shall constitute a binding agreement between each of the Underwriters and the
Company.  It is understood that your acceptance of this letter on behalf of
each of the Underwriters is pursuant to the authority set forth in a form of
Agreement among Underwriters, the form of which shall be submitted to the
Company for examination upon request, but without warranty on your part as to
the authority of the signers thereof.


                                        Very truly yours,

                                        Applied Analytical Industries, Inc.

                                        By:  /s/ Frederick D. Sancilio
                                             ---------------------------------
                                             Name:  Frederick D. Sancilio
                                             Title: President and Chief
                                                    Executive Officer

Accepted as of the date hereof:

Goldman, Sachs & Co.
Cowen & Company
Lehman Brothers Inc.


     /s/  Goldman, Sachs & Co.
- ---------------------------------------
         (Goldman, Sachs & Co.)

  On behalf of each of the Underwriters



                                       23


<PAGE>   24
 
                                                         
                                                         
                                   SCHEDULE I


<TABLE>
<CAPTION>
                                                        NUMBER OF OPTIONAL
                                                           SHARES TO BE
                                       TOTAL NUMBER OF     PURCHASED IF
                                         FIRM SHARES      MAXIMUM OPTION
         UNDERWRITER                   TO BE PURCHASED      EXERCISED
         -----------                   ---------------  ------------------
<S>                                       <C>                 <C>
Goldman, Sachs & Co.                        650,000            97,500
Cowen & Company                             650,000            97,500
Lehman Brothers Inc.                        650,000            97,500
Adams, Harkness & Hill, Inc.                 70,000            10,500
William Blair & Company                      70,000            10,500
Alex. Brown & Sons Incorporated             110,000            16,500
Dean Witter Reynolds Inc.                   110,000            16,500
Furman Selz LLC                              70,000            10,500
Hambrecht & Quist LLC                       110,000            16,500
Morgan Keegan & Company, Inc.                70,000            10,500
The Robinson-Humphrey Company, Inc.          70,000            10,500
Scott & Stringfellow, Inc.                   70,000            10,500
                                          ---------           -------
       Total........................      2,700,000           405,000
                                          =========           =======
</TABLE>




                                       24


<PAGE>   25
 


                                                                         ANNEX I

     Pursuant to Section 8(e) of the Underwriting Agreement, the accountants
shall furnish letters to the Underwriters to the effect that:

          (i) They are independent certified public accountants with respect to
     the Company and its subsidiaries within the meaning of the Act and the
     applicable published rules and regulations thereunder;

          (ii) In their opinion, the financial statements and any supplementary
     financial information and schedules (and, if applicable, financial
     forecasts and/or pro forma financial information) examined by them and
     included in the Prospectus or the Registration Statement comply as to form
     in all material respects with the applicable accounting requirements of
     the Act and the related published rules and regulations thereunder; and,
     if applicable, they have made a review in accordance with standards
     established by the American Institute of Certified Public Accountants of
     the unaudited consolidated interim financial statements, selected
     financial data, pro forma financial information, financial forecasts
     and/or condensed financial statements derived from audited financial
     statements of the Company for the periods specified in such letter, as
     indicated in their reports thereon, copies of which have been separately
     furnished to the representatives of the Underwriters (the
     "Representatives");

          (iii) They have made a review in accordance with standards
     established by the American Institute of Certified Public Accountants of
     the unaudited condensed consolidated statements of income, consolidated
     balance sheets and consolidated statements of cash flows included in the
     Prospectus as indicated in their reports thereon copies of which have been
     separately furnished to the Representatives and on the basis of specified
     procedures including inquiries of officials of the Company who have
     responsibility for financial and accounting matters regarding whether the
     unaudited condensed consolidated financial statements referred to in
     paragraph (vi)(A)(i) below comply as to form in all material respects with
     the applicable accounting requirements of the Act and the related
     published rules and regulations, nothing came to their attention that
     cause them to believe that the unaudited condensed consolidated financial
     statements do not comply as to form in all material respects with the
     applicable accounting requirements of the Act and the related published
     rules and regulations;

          (iv) The unaudited selected financial information with respect to the
     consolidated results of operations and financial position of the Company
     for the five most recent fiscal years included in the Prospectus agrees
     with the corresponding amounts (after restatements where applicable) in
     the audited consolidated financial statements for such five fiscal years
     which were included or incorporated by reference in the Company's Annual
     Reports on Form 10-K for such fiscal years;

          (v) They have compared the information in the Prospectus under
     selected captions with the disclosure requirements of Regulation S-K and
     on the basis of limited procedures specified in such letter nothing came
     to their attention as a result of the foregoing procedures that caused
     them to believe that this information does not conform in all material
     respects with the disclosure requirements of Items 301, 302, 402 and
     503(d), respectively, of Regulation S-K;

          (vi) On the basis of limited procedures, not constituting an
     examination in accordance with generally accepted auditing standards,
     consisting of a reading of the unaudited financial


                                     F-1
<PAGE>   26
 

     statements and other information referred to below, a reading of the
     latest available interim financial statements of the Company and its
     subsidiaries, inspection of the minute books of the Company and its
     subsidiaries since the date of the latest audited financial statements
     included in the Prospectus, inquiries of officials of the Company and its
     subsidiaries responsible for financial and accounting matters and such
     other inquiries and procedures as may be specified in such letter, nothing
     came to their attention that caused them to believe that:

                  (A) (i) the unaudited consolidated statements of income,
             consolidated balance sheets and consolidated statements of cash
             flows included in the Prospectus do not comply as to
             form in all material respects with the applicable accounting
             requirements of the Act and the related published rules and
             regulations, or (ii) any material modifications should be made to
             the unaudited condensed consolidated statements of income,
             consolidated balance sheets and consolidated statements of cash
             flows included in the Prospectus for them to be in conformity with
             generally accepted accounting principles;

                  (B) any other unaudited income statement data and balance
             sheet items included in the Prospectus do not agree with the
             corresponding items in the unaudited consolidated financial
             statements from which such data and items were derived, and any
             such unaudited data and items were not determined on a basis
             substantially consistent with the basis for the corresponding
             amounts in the audited consolidated financial statements included
             in the Prospectus;

                  (C) the unaudited financial statements which were not
             included in the Prospectus but from which were derived any
             unaudited condensed financial statements referred to in Clause (A)
             and any unaudited income statement data and balance sheet items
             included in the Prospectus and referred to in Clause (B) were not
             determined on a basis substantially consistent with the basis for
             the audited consolidated financial statements included in the
             Prospectus;

                  (D) any unaudited pro forma consolidated condensed financial
             statements included in the Prospectus do not comply as to form in
             all material respects with the applicable accounting requirements
             of the Act and the published rules and regulations thereunder or
             the pro forma adjustments have not been properly applied to the
             historical amounts in the compilation of those statements;

                  (E) as of a specified date not more than five days prior to
             the date of such letter, there have been any changes in the
             consolidated capital stock (other than issuances of capital stock
             upon exercise of options and stock appreciation rights, upon
             earn-outs of performance shares and upon conversions of
             convertible securities, in each case which were outstanding on the
             date of the latest financial statements included in the
             Prospectus) or any increase in the consolidated long-term debt of
             the Company and its subsidiaries, or any decreases in consolidated
             net current assets or stockholders' equity or other items
             specified by the Representatives, or any increases in any items
             specified by the Representatives, in each case as compared with
             amounts shown in the latest balance sheet included in the
             Prospectus, except in each case for changes, increases or
             decreases which the


                                     F-2
<PAGE>   27
 

            Prospectus discloses have occurred or may occur or which are
            described in such letter; and

                  (F) for the period from the date of the latest financial
             statements included in the Prospectus to the specified date
             referred to in Clause (E) there were any decreases in consolidated
             net revenues or operating profit or the total or per share amounts
             of consolidated net income or other items specified by the
             Representatives, or any increases in any items specified by the
             Representatives, in each case as compared with the comparable
             period of the preceding year and with any other period of
             corresponding length specified by the Representatives, except in
             each case for decreases or increases which the Prospectus
             discloses have occurred or may occur or which are described in
             such letter; and

     (vii) In addition to the examination referred to in their report(s)
     included in the Prospectus and the limited procedures, inspection of
     minute books, inquiries and other procedures referred to in paragraphs
     (iii) and (vi) above, they have carried out certain specified procedures,
     not constituting an examination in accordance with generally accepted
     auditing standards, with respect to certain amounts, percentages and
     financial information specified by the Representatives, which are derived
     from the general accounting records of the Company and its subsidiaries,
     which appear in the Prospectus, or in Part II of, or in exhibits and
     schedules to, the Registration Statement specified by the Representatives, 
     and have compared certain of such amounts, percentages and financial
     information with the accounting records of the Company and its
     subsidiaries and have found them to be in agreement.




                                      F-3

                                      

<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
FINANCIAL STATEMENTS OF APPLIED ANALYTICAL INDUSTRIES, INC. AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-START>                             JAN-01-1996
<PERIOD-END>                               SEP-30-1996
<CASH>                                          47,838
<SECURITIES>                                         0
<RECEIVABLES>                                   10,562
<ALLOWANCES>                                        90
<INVENTORY>                                          0
<CURRENT-ASSETS>                                64,604
<PP&E>                                          25,206
<DEPRECIATION>                                  10,682
<TOTAL-ASSETS>                                  81,502
<CURRENT-LIABILITIES>                            8,920
<BONDS>                                              0
                                0
                                          0
<COMMON>                                            16
<OTHER-SE>                                      69,300
<TOTAL-LIABILITY-AND-EQUITY>                    81,502
<SALES>                                         31,170
<TOTAL-REVENUES>                                31,170
<CGS>                                           13,010
<TOTAL-COSTS>                                   13,010
<OTHER-EXPENSES>                                14,436
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 353
<INCOME-PRETAX>                                  3,663
<INCOME-TAX>                                     1,468
<INCOME-CONTINUING>                              2,195
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     2,195
<EPS-PRIMARY>                                     0.18
<EPS-DILUTED>                                     0.18
        

</TABLE>


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