APPLIED ANALYTICAL INDUSTRIES INC
8-K, 1997-01-15
MEDICAL LABORATORIES
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<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                    FORM 8-K



             CURRENT REPORT PURSUANT TO SECTION 13 OR 15 (D) OF THE
                        SECURITIES EXCHANGE ACT OF 1934



      Date of Report (Date of earliest event reported): December 31, 1996
                                                       ------------------


                      APPLIED ANALYTICAL INDUSTRIES, INC.
                      -----------------------------------
             (Exact Name of Registrant as Specified in its Charter)



                                    Delaware
                                    --------
         (State or Other Jurisdiction of Incorporation or Organization)



           0-21185                                     04-2687849
           -------                                     ----------
   (Commission File Number)             (I.R.S. Employer Identification Number)


                             5051 New Centre Drive
                        Wilmington, North Carolina 28403
                        --------------------------------
              (Address of Principal Executive Offices) (Zip Code)



                                 (910) 392-1606
                                 --------------
              (Registrant's Telephone Number, Including Area Code)



                                       1
<PAGE>   2
                      APPLIED ANALYTICAL INDUSTRIES, INC.

                                    FORM 8-K

      (Any item which is not applicable or to which the answer is negative
                               has been omitted.)


Item 2.  Acquisition or Disposition of Assets.

On December 31, 1996, Applied Analytical Industries, Inc. ("AAI"), through its
wholly-owned subsidiary, My Asset Management GmbH, exercised options to acquire
all of the outstanding ownership of L.A.B. Gesellschaft fur pharmakologische 
Untersuchungen mbH & Co. ("L.A.B."). The controlling ownership interest was 
acquired from Friedrich Herzog von Wurttemberg.

L.A.B. is a European contract research and development organization
headquartered in Neu-Ulm, Germany with operational units in Neu-Ulm, Stuttgart
and Munich, Germany as well as in France, Holland, England and Hungary. It
employs approximately 250 scientists, technicians and support personnel, 60 or
more with Ph.D. or M.D. degrees. L.A.B. focuses on both niche clinical and non-
clinical pharmaceutical product development and provides services that include
drug formulation development; chemical analysis; Phase I clinical studies;
bioanalytical testing; and European regulatory consulting. The firm also
provides controlled Phase II-A studies and multi-center trials focused in niche
therapeutic areas including hepatic disease, chemotherapeutics, and hormone
replacement therapy.

The acquisition will be accounted for using the purchase method of accounting.
The aggregate acquisition cost, including current and deferred payments to
former owners, amounts advanced to L.A.B. to retire existing bank debt and other
liabilities, contingencies and acquisition costs, is approximately $18 million.
The acquisition will be funded through the release of an escrow deposit; current
cash payments from existing cash balances of AAI, exclusive of any proceeds from
its recent initial public offering; with the remainder, including deferred
payments to former owners, payments on L.A.B. bank debt and other liabilities
and contingencies expected to be paid out over the next few years with working
capital from operations.



                                       2
<PAGE>   3
Item 7.  Financial Statements and Exhibits.

         (a) Financial statements the business acquired:

             The audited financial statements of the acquired business for the
             periods specified in Rule 3-05(b) of Regulation S-X are not
             available at this time. Such financial statements will be filed as
             an amendment to this Form 8-K on or before March 17, 1997.

         (b) Pro forma financial information:

             The pro forma financial information specified in Article 11 of
             Regulation S-X is not available at this time. Such information
             will be filed as an amendment to this Form 8-K at the time the
             above financial statements are filed.

         (c) Exhibits:

             Exhibit No.                      Description

                2.1*                Option Agreement between Applied Analytical
                                    Industries, Inc. and My Asset Management
                                    GmbH and Friedrich Herzog von Wurttemberg.

                2.2*                Purchase and Assignment Agreement between
                                    Friedrich Herzog von Wurttemberg and My
                                    Asset Management GmbH


- ------------------------------------
* Schedules and appendices to such documents have been omitted and will be
supplementally provided to the Securities and Exchange Commission upon request.



                                       3
<PAGE>   4
                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                      APPLIED ANALYTICAL INDUSTRIES, INC.

Date: January 15, 1997                By: /s/ Frederick D. Sancilio
                                         --------------------------------------
                                         Frederick D. Sancilio, Ph.D.
                                         President and Chief Executive Officer



                                       4
<PAGE>   5
                      APPLIED ANALYTICAL INDUSTRIES, INC.

                                 EXHIBIT INDEX



             Exhibit No.                      Description

                2.1*                Option Agreement between Applied Analytical
                                    Industries, Inc. and My Asset Management 
                                    GmbH and Friedrich Herzog von Wurttemberg.

                2.2*                Purchase and Assignment Agreement between 
                                    Friedrich Herzog von Wurttemberg and My
                                    Asset Management GmbH


- ------------------------------------
* Schedules and appendices to such documents have been omitted and will be
supplementally provided to the Securities and Exchange Commission upon request.




                                       5

<PAGE>   1

                                                                    EXHIBIT 2.1

                                                            English Translation


                                OPTION AGREEMENT


                                    BETWEEN


Applied Analytical Industries, Inc.
1206 North 23rd Street
Wilmington, NC 28405
U.S.A.
                                                                         ("AAI")

and

My Asset Management GmbH
(Future name: Applied Analytical Industries Deutschland GmbH)
c/o Shearmen & Sterling
CouvenstraBe 8, 40211 Dusseldorf
Germany
                                                                       ("NewCo")

                                                             - ON THE ONE SIDE -


                                     A N D


Friedrich Herzog von Wurttemberg
Schloss
88045 Friedrichshafen
Germany
                                                               (the "Hofkammer")

                                                           - ON THE OTHER SIDE -




(AAI, NewCo and the Hofkammer are hereinafter collectively referred to as the
"Parties".)
 
<PAGE>   2
                                      4
 

TABLE OF CONTENTS


<TABLE>
<S>                                                                                                                    <C>
Directory of Annexes  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

Introduction  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

1        Call Option  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7

2        Financial Commitments by the Hofkammer Towards NewCo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

3        Financial Commitments by AAI Towards Hofkammer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

4        Lease Agreement  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

5        Prior Agreements; Distribution of Escrow Funds; Option Fee . . . . . . . . . . . . . . . . . . . . . . . . .  11

6        Miscellaneous  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  12
</TABLE>


 
<PAGE>   3
                                      5



DIRECTORY OF ANNEXES

Annex 1.3 - Purchase Agreement

Annex 4.1 - Lease Agreement


 
<PAGE>   4
                                       6


INTRODUCTION

A.       Since May 10, 1995, the Hofkammer is holding a limited partnership
         interest of DM 1,500,000 representing 75% of the limited liability
         capital in L.A.B. Gesellschaft fur pharmakologische Untersuchungen mbH
         & Co., Neu-Ulm ("L.A.B."). Since July 31, 1995, the Hofkammer is
         holding three shares with an aggregate nominal value of DM 50,000 in
         L.A.B. GmbH & Co. KG's general partner, L.A.B. Verwaltungsgesellschaft
         mbH, Neu-Ulm (the Partner GmbH ), representing all of the share
         capital of the  Partner GmbH. Before that time the Hofkammer did not
         hold any interest in either L.A.B. or the Partner GmbH. The
         Hofkammer's sole aim in acquiring these interests was to secure for
         the time being L.A.B. as a going concern including the preservation of
         jobs and thereby avoiding the loss of its own claims against L.A.B.,
         including payment of outstanding rent. Hofkammer was not active in the
         business of L.A.B., nor will be in the future and wishes therefore to
         sell its interests in L.A.B. and the Partner GmbH.

B.       AAI is active in the same business as L.A.B. and intends to expand its
         operations in Europe. AAI therefore is interested to purchase the
         aforementioned interests of Hofkammer.

C.       On May 28, 1996 the Parties entered into an Exclusive Option Agreement
         which was notarized by Notary Dr.  Patrick Wamister in Bale on July 8,
         1996. This Exclusive Option Agreement granted AAI a six-month
         exclusive option period which in the meantime was extended until
         December 9, 1996. Under such agreement AAI was entitled to request
         that Hofkammer sells its interests in the Partner GmbH and L.A.B.,
         which interests at the time of such sale would represent all of its
         interests in and to L.A.B. and the Partner GmbH (the "Transaction").
         By letter agreement dated December 9, 1996, the Hofkammer granted to
         AAI exclusivity for a period until December 24, 1996.
 
<PAGE>   5
                                       7


In consideration thereof, the Parties agree as follows:



1        CALL OPTION

         1.1     The Hofkammer hereby irrevocably grants to NewCo, subject to
                 the terms and conditions stated hereinafter, an option (the
                 "Call Option") to require the Hofkammer to sell to NewCo

                 (i)      all outstanding shares in the Partner GmbH
                          representing a total nominal capital (Stammkapital)
                          of DM 50,000 (the "GmbH Shares") and,

                 (ii)     all of Hofkammer's partnership interest in L.A.B.
                          representing today a 75% participation in L.A.B.,
                          with a registered limited liability amount
                          (Haftkapital) of DM 1,500,000 (the "L.A.B.
                          Partnership Interest"),

                 (The GmbH Shares and the L.A.B. Partnership Interest are
                 hereinafter collectively referred to as the "L.A.B.
                 Interests".)

         1.2     NewCo may only exercise the Call Option until January 2, 1997
                 (the Call Option Period ). For the purpose of executing the
                 Call Option, the Hofkammer hereby irrevocably offers to NewCo
                 to sell the L.A.B. Interests within the Call Option Period by
                 accepting the offer of the Hofkammer by notarial deed. NewCo
                 shall give a notice to the Hofkammer promptly after having
                 accepted the offer.

         1.3     The purchase of the L.A.B. Interests by NewCo pursuant to the
                 exercise of the Call Option shall take place pursuant to the
                 purchase agreement attached as Annex 1.3 (the "Purchase
                 Agreement"). Such Purchase Agreement shall become effective on
                 January 1, 1997, 00:00 o'clock or on December 31, 1996, 23:59
                 o'clock, at the choice of NewCo (the "Effective Date").
 
<PAGE>   6
                                       8


         1.4     Any exercise of the Call Option by NewCo shall in no way
                 constitute a waiver of any warranty rights or otherwise affect
                 any rights of NewCo under the Purchase Agreement unless
                 specifically otherwise stipulated.


2        FINANCIAL COMMITMENTS BY THE HOFKAMMER TOWARDS NEWCO

         In case the Call Option is validly exercised and NewCo pays the
         Purchase Price under clause 4.2 (i) of the Purchase Agreement, the
         Hofkammer herewith agrees as part of a global finacial reorganization
         (Sanierung)

                 (i)      to waive all of its claims against L.A.B. or against
                          any other company of L.A.B. (the "L.A.B.  Group")
                          with effect as of the day preceding the Effective
                          Date except for an amount of DM 2,928,000 plus V.A.T.
                          if applicable (the "Hofkammer Entitlement") which is
                          part of the Purchase Price under the Purchase
                          Agreement,,

                 (ii)     that neither L.A.B. nor any other company of the
                          L.A.B. Group shall make any payments for outstanding
                          rent or otherwise to the Hofkammer after November 26,
                          1996, and that Hofkammer shall reimburse to NewCo any
                          excess payments received thereafter, if any, plus
                          interest in an amount of 5.5% p.a.

3        FINANCIAL COMMITMENTS BY AAI TOWARDS HOFKAMMER

         In case the Call Option is validly exercised, AAI herewith guarantees
         that NewCo will pay the full amount of the purchase price as stated in
         clause 4 of the Purchase Agreement. Upon request AAI shall provide to
         Hofkammer a bank guarantee of a German bank of Hofkammer's choice
         securing outstanding payments of the Purchase Price, provided that
         Hofkammer bears the cost of such a bank guarantee.
 
<PAGE>   7
                                       9


4        LEASE AGREEMENT

         4.1     If the Call Option is validly exercised and NewCo pays the
                 Purchase Price under clause 4.2 (i) of the Purchase Agreement,
                 the Hofkammer and NewCo will take responsibility that the
                 Hofkammer Grundstucksgesellschaft GBR mbH and L.A.B. shall
                 amend the current two lease agreements relating to the head
                 offices of L.A.B. (the "Property") which are attached as Annex
                 4.1 (the Lease Agreements) as follows with effect as of the
                 Effective Date (the "Lease Commencement Date"):

                 4.1.1    The term of the Lease Agreements shall unitarily end
                          five years after the Lease Commencement Date. L.A.B.
                          has an option to extend the Lease Agreements for one
                          additional period of five years. Such option to be
                          exercised by written notice to the Hofkammer
                          Grundstucksgesellschaft GBR mbH at least 18 months
                          before expiration of the first five-year term.

                 4.1.2    As of the Lease Commencement Date the aggregate
                          yearly rent due for the first three years under the
                          Lease Agreements shall amount to DM 1,000,000 plus
                          V.A.T., payable on a monthly basis not later than on
                          the 15th of each month. After the third anniversary
                          of the Lease Commencement Date, such rent shall be
                          adjusted to market conditions in the Ulm area, if
                          possible on the basis of comparable properties at
                          comparable locations. In determining such market rent
                          any structural measures and installations financed by
                          the lessor which increase the value of the Property
                          shall be taken into consideration when fixing the
                          rent, but it shall not include improvements financed
                          by the lessee. In each such case, any rent adjustment
                          will be implemented on a forward looking basis only.

                          In case L.A.B. and the Hofkammer
                          Grundstucksverwaltungsgesellschaft cannot agree on
                          such adjustment of the rent, the amount of the rent
                          shall be determined by a pub-
<PAGE>   8
                                       10


                          licly sworn expert to be jointly commissioned by the
                          Parties who shall act as an appraiser
                          (Schiedsgutachter) in the meaning of sect. 317 Civil
                          Code (BGB). The appraiser's determination shall be
                          binding. If the Parties are unable to agree on such
                          an appraiser, then he/she shall be appointed by the
                          President of the Ulm Chamber of Industry and Commerce
                          after hearing of the parties. The costs of the
                          appraisal shall be borne by the Parties in accordance
                          with sect. 91 Civil Procedure Act (ZPO).

                          The rent adjusted as described shall be applicable
                          until the end of the first five-year term.  If L.A.B.
                          exercises the option for another five-year term, the
                          rent for such additional term shall be determined by
                          the same procedure as described in clause 4.1.2,
                          second sentence, above, including a customary index
                          clause.

                 4.1.3    In case that more than 50% of the property is
                          destroyed or otherwise not useable as intended,
                          L.A.B. may terminate the Lease Agreements with
                          immediate effect and is in any case entitled to
                          reduce the rent adequately.

                 4.1.4    All other terms of the Lease Agreements shall remain
                          in full force and effect. In the event of differences
                          between the two lease agreements, the one dated
                          October 22, 1992/January 4, 1993 shall prevail.

         4.2     Any rent owed by L.A.B. pursuant to clause 4.1 is herewith
                 guaranteed by NewCo. For this purpose AAI declares the
                 following:

                 NewCo is a wholly owned subsidiary of AAI. NewCo is entrusted
                 with all of the activities of AAI in Germany. AAI intends to
                 continue to control NewCo and to entrust NewCo with its future
                 business activities in Germany. If AAI decides to cause
                 changes with respect to the control of NewCo and/or NewCo's
                 entrustment with AAI's business activities in Germany, AAI
                 will give the Hofkammer prior written notice upon which the
                 Hofkammer and AAI will
<PAGE>   9
                                       11


                 agree on a solution which is comparable for the Hofkammer with
                 the situation as mentioned in the first two sentences.

         4.3     AAI and the Hofkammer shall procure that L.A.B. and Hofkammer
                 Grundstucksgesellschaft GBR mbH shall execute as soon as
                 possible a new lease agreement in due form reflecting the
                 terms of this clause 4. As part of such new lease agreement
                 the Hofkammer shall procure NewCo or its assignee one option
                 to acquire of the three buildings presently used by L.A.B. and
                 the underlying land.  The conditions for such purchase shall
                 be based on market value; such option to be registered at the
                 land register (Grundbuch). In case the parties cannot agree on
                 market value, an independent expert acting as an appraiser
                 shall determine such market conditions.  Until said option is
                 duly registered Hofkammer shall take responsibility that the
                 property will not be sold or otherwise transferred to a third
                 party.


5        Prior Agreements; Distribution of Escrow Funds; Option Fee

         5.1     This Agreement supersedes in its entirety the Exclusive Option
                 Agreement, except for the Escrow Agreement which is part of
                 the Exclusive Option Agreement and which will remain in full
                 force and effect.

         5.2     It is understood that in case the Call Option is not validly
                 exercised, the Hofkammer is obliged to agree that the Escrow
                 Fund as defined in the Escrow Agreement including interest
                 shall be distributed to AAI, except for an amount in the
                 equivalent of $15,000 (currency value as of the Effective
                 Date); such amount to be regarded as an option fee for the
                 Hofkammer as consideration for the granting of the Call Option
                 hereunder.

         5.3     In case that the Call Option is validly exercised, AAI is
                 obliged to agree that the Escrow Fund shall be distributed to
                 the Hofkammer as satisfaction of the purchase price stated
                 under clause 4.2 (i) of the Purchase Agreement.
<PAGE>   10
                                       12


6        MISCELLANEOUS

         6.1     In case the Call Option is validly exercised, only NewCo is
                 entitled and obliged to inform the Partner GmbH about the
                 transfer of the GmbH Shares pursuant to sect. 16 (1) Limited
                 Corporation Act (GmbHG).

         6.2     Each Party shall bear its own costs and expenses in connection
                 with the negotiation, preparation and implementation of this
                 Agreement with the exception of notarial and court costs and
                 similar charges which shall be shared equally between the
                 Parties. Transfer taxes will be borne by NewCo.

         6.3     If any of the provisions contained in this Agreement are or
                 become invalid or impracticable for any reason, including by
                 virtue of the omission of any other provision, the validity of
                 the remaining provisions shall remain unaffected. The invalid
                 or impracticable provision shall be substituted or
                 supplemented by provisions that ensure the economic purpose of
                 the invalid or impracticable provision as far as possible.

         6.4     Unless otherwise specified in this Agreement, all notices and
                 other communications hereunder shall be in writing and in
                 English.

                          IF TO THE HOFKAMMER:
                                Hofkammer des Hauses Wurttemberg
                                - Direktion -
                                SchloB
                                88045 Friedrichshafen
                                Fax (+49-7541) 307-126

                          IF TO NEWCO:
                                Applied Analytical Industries Deutschland GmbH
                                c/o Shearman & Sterling
                                CouvenstraBe 8
                                40211 Dusseldorf
                                Fax (+49-211) 1 78 88-88
<PAGE>   11
                                       13



                          IF TO AAI:
                                Applied Analytical Industries, Inc.
                                attn. General Counsel
                                5051 New Centre Drive
                                Wilmington, NC 28403
                                U.S.A.
                                Fax: (+1-910) 392-6557

                 6.5      All Annexes in this Agreement are considered a part
                          hereof.

                 6.6      Each of the Parties shall execute and deliver all
                          such further documents and agreements and do such
                          further acts as are reasonably required hereby and
                          are not inconsistent with any other provisions of
                          this Agreement.

                 6.7      The Parties agree to keep confidential all
                          information obtained in connection with this
                          Agreement and its performance as long as and to the
                          extent that it has not been made known to the public
                          without fault of any of the Parties. If this
                          Agreement is terminated for any reason, this
                          confidentiality obligation shall remain in effect
                          indefinitely.

                 6.8      Neither this Agreement nor any right hereunder may be
                          assigned without the prior written consent of the
                          other Parties unless specifically stated otherwise.
                          Any attempt to assign any right hereunder without
                          such approval will be void unless it is an assignment
                          or transfer by operation of law. Subject to the
                          preceding sentence, this Agreement is binding upon,
                          inures to the benefit of, and is enforceable by the
                          Parties and their respective successors and
                          assignees.

                 6.9      Each Party shall execute any further legal acts which
                          are required to achieve the goal of this agreement.
                          This also includes that the Hofkammer, upon request,
                          will render all necessary statements so that for the
                          Buyer no undesirable consequences will result from
                          the exclusion of the Jaegers agreed on by the
                          shareholders' meeting.  This clause 6.9 contains no
                          financial commitments for either Party.
 
<PAGE>   12
                                       14


                 6.10     This Agreement shall be governed by the laws of the
                          Federal Republic of Germany. The exclusive place of
                          jurisdiction is Frankfurt am Main.


IN WITNESS THEREOF, this public deed and the Annexes have been read out in
their entirety in the presence of the appeared persons and in my presence.
After reading, this public deed and the Annexes have been found to be correct
and approved. After that the appeared persons have signed the public deed in my
presence, thereupon I, the notary public, have also signed this public deed and
affixed my official seal.


BALE, this 23rd (twenty-third) day of December 1996 (nineteen hundred and
ninety-six)


[Signatures and seal of notary public.]

<PAGE>   1

                                                                    EXHIBIT 2.2

                                                            ENGLISH TRANSLATION



                                                                       ANNEX 1.3
                                                         OF THE OPTION AGREEMENT




                       PURCHASE AND ASSIGNMENT AGREEMENT




                                    BETWEEN


Friedrich Herzog von Wurttemberg
Schloss
88045 Friedrichshafen
Germany
                                                               (the "Hofkammer")



                                     A N D



My Asset Management GmbH
c/o Shearman & Sterling
Couvenstr. 8
40211 Dusseldorf
Germany
                                                                       ("NewCo")



(The Hofkammer and NewCo are hereinafter collectively referred to as the
"Parties".)


<PAGE>   2
                                       2


INTRODUCTION

Applied Analytical Industries, Inc. ("AAI"), being the sole shareholder of
NewCo, the Hofkammer and Baden-Wurttembergische Bank AG have entered into an
escrow agreement (the "Escrow Agreement") in July 1996 as stipulated in the
Exclusive Option Agreement (notarial deed Allg. Prot. No. 133 of the notary
public Dr. Patrick Wamister, Bale) which was entered into by AAI and the
Hofkammer.

AAI has deposited under the Escrow Agreement at Baden-Wurttembergische Bank AG
an amount of DM 1,575,000 (the "Escrow Fund") to be applied to any purchase of
L.A.B. by AAI or a subsidiary.

In consideration hereof, the Parties agree as follows:


1.       FACTS AS OF THE EFFECTIVE DATE

         1.1     The Hofkammer is a limited partner (Kommanditistin) of L.A.B.
                 Gesellschaft fur pharmakologische Untersuchungen mbH & Co. (
                 "L.A.B."). The Hofkammer's limited partnership interest (the
                 "Limited Partnership Interest") with a registered liability
                 amount of DM 1,500,000 has been fully paid in cash.  L.A.B. is
                 registered at the commercial register of Amtsgericht Memmingen
                 under HR A 6951.

         1.2     The Hofkammer is also the sole shareholder of L.A.B.
                 Verwaltungsgesellschaft mbH ( Partner GmbH ) and is holding
                 three shares, one share with a nominal value of DM 25,000 and
                 two shares each with a nominal value of DM 12,500 representing
                 100% of the stated capital (Stammkapital) in the amount of DM
                 50,000 of Partner GmbH (hereinafter the GmbH Shares ). The
                 Partner GmbH is registered at the commercial register of
                 Memmingen under HR B 6885.
<PAGE>   3
                                       3


         1.3     The Partner GmbH is the sole general partner (Komplementarin)
                 of L.A.B.


2.       SALE AND ASSIGNMENT

         2.1     The Hofkammer hereby sells to NewCo and NewCo hereby purchases
                 from the Hofkammer the GmbH Shares. The transfer of the GmbH
                 Shares shall have economic effect as of the Effective Date, as
                 defined hereinafter. NewCo shall be entitled to all dividend
                 rights and all other secondary rights of the Shares.

                 The Hofkammer hereby assigns to NewCo the GmbH Shares with
                 effect in rem as of the Effective Date, as defined hereinafter
                 and NewCo accepts such assignment.

         2.2     The Hofkammer hereby sells to NewCo and NewCo hereby purchases
                 from the Hofkammer the L.A.B.  partnership interest including
                 all capital accounts and any other rights the Hofkammer may
                 have in L.A.B. The transfer of the Limited Partnership
                 Interest shall have economic effect as of the Effective Date.

                 The Hofkammer hereby assigns to NewCo the Limited Partnership
                 Interest with effect in rem as of registration of NewCo in the
                 commercial register as successor in law
                 (Sonderrechtsnachfolgerin) of the Hofkammer.


3.       EFFECTIVE DATE

         The Effective Date of this Agreement is January 1, 1997, 0:00 o'clock
         or December 31, 1996, 23:59 o'clock, at the choice of NewCo.
 
<PAGE>   4
                                       4


4.       PURCHASE PRICE

         4.1     The purchase price owed by NewCo for the GmbH Share and the
                 L.A.B. Limited Partnership Interest amounts to DM 6,553,000
                 (in words: Deutsche Mark six million five hundred and
                 fifty-three thousand) (the "Purchase Price").

         4.2     The Purchase Price is due and payable as follows:

                 (i)      DM 4,503,000 15 banking days in Baden-Wurttemberg
                          after the Effective Date from a distribution of the
                          Escrow Fund plus additional cash;

                 (ii)     DM 600,000 on January 2, 1998;

                 (iii)    DM 700,000 on January 2, 1999;

                 (iv)     DM 750,000 on January 2, 2000.

         4.3     AAI may offset counterclaims against Hofkammer, whatever their
                 cause in law, only insofar as such counterclaims are finally
                 and absolutly judicially determined or are acknowledged by
                 Hofkammer.  This also applies to counterclaims for warranty or
                 damages claims asserted on the basis of this Agreement.


5.       HOFKAMMER'S REPRESENTATION AND WARRANTIES

         5.1     The Hofkammer represents and warrants in form of an
                 independent guarantee (selbstandiges Garantieversprechen) as
                 of the Effective Date that:

                 5.1.1    it is the sole owner of the fully paid in GmbH Shares
                          and of the fully paid in Limited Partnership Interest
                          (hereinafter
<PAGE>   5
                                       5


                          collectively the "L.A.B. Interests") and is entitled
                          to sell and transfer to NewCo the full legal and
                          beneficial ownership of the L.A.B. Interests, and
                          NewCo hereby will own such interests free and clear
                          from any encumbrances and will thereby become the
                          sole owner of the L.A.B. Interests;

                 5.1.2    no third party has any interest in the Partner GmbH
                          and in L.A.B., provided, however, that this
                          representation shall not apply to Ms. Jaeger's and
                          Dr. Jaeger's interests in L.A.B. with a registered
                          liability amount of DM 125,000 and DM 375,000,
                          respectively;

                 5.1.3    the Partner GmbH has a net equity (Eigenkapital in
                          the meaning of sect. 266 III A HGB) in the amount of
                          at least DM 50,000 notwithstanding any liabilities
                          connected with its position as a general partner of
                          L.A.B.;

                 5.1.4    the L.A.B. Interests are not subject to any
                          restrictions on disposition, any preemptive rights,
                          option rights, rights of first refusal or similar
                          rights of third parties;

                 5.1.5    the facts stated in clause 1 are true and correct;

                 5.1.6    the capital represented by the L.A.B. Interests have
                          not been paid back at any time after May 10, 1995,
                          and no additional contribution obligations in cash or
                          in kind (NachschuBpflichten) exist with respect to
                          the L.A.B. Interests;

                 5.1.7    there are no voting trusts, stockholder agreements,
                          proxies or other agreements or understandings in
                          effect with respect to the voting or transfer of the
                          L.A.B. Interests except as provided for in the
                          articles of incorporation of the Partner GmbH and the
                          partnership agreement of L.A.B.; for the avoidance of
                          doubt: the purchase price in the amount of
<PAGE>   6
                                       6


                          DM 5,000 paid by the Hofkammer to Dr. Jaeger for the
                          GmbH shares is not deemed to be a repayment as such;

                 5.1.8    the L.A.B. Interests do not constitute the entire
                          property of the Hofkammer within the meaning of sect.
                          419 of the Civil Code (BGB);

                 5.1.9    APPENDIX 5.1.9 contains a true and correct copy of
                          the articles of incorporation (Gesellschaftsvertrag)
                          of the Partner GmbH;

                 5.1.10   APPENDIX 5.1.10 contains a true and correct copy of
                          the partnership agreement of L.A.B.; this, however,
                          shall not be a guarantee that the changes to the
                          Partnership Agreement dated March 27, 1996, and
                          September 9, 1996, are effective and binding;

                 5.1.11   APPENDIX 5.1.11 contains a true and correct list of
                          all of the subsidiaries of L.A.B. and the Partner
                          GmbH including the amount of shareholding (the
                          "Subsidiaries");

                 5.1.12   except for the bonus entitlements
                          (Erfolgsbeteiligung) of Mr. Feichter and Dr. Kappler
                          and certain employees, all as further described in
                          Appendix 5.1.12, neither the Partner GmbH nor L.A.B.
                          is bound by any control, profit transfer or other
                          agreements of the type referred to in sect. 291, 292
                          et seq. of the Stock Corporation Act (Aktiengesetz),
                          and no silent participations (stille Beteiligungen),
                          profit participating loans (partiarische Darlehen),
                          profit participations of management or employees or
                          other similar obligations exist with respect to the
                          profits of L.A.B. and/or the Partner GmbH;

                 5.1.13   between the date of this notarial deed and the
                          Effective Date, the business will be conducted in the
                          ordinary course
<PAGE>   7
                                       7


                          and consistent with past practice, and the Hofkammer
                          shall cause the Partner GmbH, L.A.B. and the
                          Subsidiaries not to enter into any transaction
                          outside the ordinary course of business without the
                          prior consent of NewCo. As amplification and not
                          limitation of the foregoing, the Partner GmbH, L.A.B.
                          and/or the Subsidiaries will not:

                          (i)     make any loan to, guarantee any indebtedness
                                  of or otherwise incur any indebtedness on
                                  behalf of the Hofkammer or any third party or
                                  assume any other unusual obligations;

                          (ii)    redeem any of the capital or declare, make or
                                  pay any profit distributions (whether in
                                  cash, securities or other property);

                          (iii)   enter into any arrangement under or similar
                                  to the Transformation Law
                                  (Umwandlungsgesetz);

                          (iv)    purchase any assets or make any investments
                                  in excess of DM 50,000 (in words: Deutsche
                                  Mark fifty thousand), without the prior
                                  written consent of NewCo;

                          (v)     hire new employees;

                          clause 6.2, second half sentence, shall remain
                          unaffected.

                 5.1.14   neither L.A.B. nor any of its Subsidiaries has, or
                          will have, any liability (whether actual, contingent
                          or disputed and whether having arisen before or
                          arising after September 30, 1996) effectively
                          attributable to the period on or before September 30,
                          1996 (the "Unrecorded Liabilities"), except to the
                          extent reflected in the interim financial statements
                          as of
<PAGE>   8
                                       8


                          September 30, 1996, contained in Appendix 5.2.3,
                          provided that Unrecorded Liabilities up to an amount
                          of DM 3,200,000 shall not constitute a breach of this
                          clause  5.1.14. Unrecorded Liabilities as used herein
                          do not include

                          (i)     liabilities of L.A.B. connected with the law
                                  suit filed by Apotex, Inc. against various
                                  companies including L.A.B. and the Partner
                                  GmbH, at the Ontario Court (General
                                  Division), Canada, in an amount of
                                  US$188,306.80 and Canadian $40,000,000 (Court
                                  File No. 94-CQ-50477), and

                          (ii)    tax liabilities of IPA-Internationale
                                  Pharmaagentur GmbH and Inpharmco GmbH
                                  Gesellschaft zur Vermarktung von
                                  Arzneimitteln up to an amount of DM 1,300,000
                                  in the aggregate for the business years up to
                                  1992, regardless to which extent reflected in
                                  the Reference Balance Sheet, and

                          (iii)   any kind of liabilities other than tax
                                  liabilities which AAI or any of the persons
                                  who acted in the interest of AAI during the
                                  negotiations and the due diligence have
                                  knowledge of.

                          The Hofkammer shall not be liable for any of  the
                          liabilities stated under (i) through  (iii).

         5.2     The Hofkammer herewith warrants and represents to its best
                 knowledge, whereby only the knowledge of Hofkammerprasident
                 Dr. Hans-Joachim Kay and of Dr. Martin Schockenhoff is
                 attributable to the Hofkammer, and provided that neither the
                 Hofkammer nor its officers, advisors or agents have any duty
                 to make affirmative inquiry into any facts or circumstances
                 except after due inquiry with Mr. Josef Feichter and Dr.
                 Joachim Kappler, both managing direc-
<PAGE>   9
                                       9


                 tors of the Partner GmbH as of the date hereof and having
                 confirmed in writing that as of the date hereof

                 5.2.1    sufficient insurance policies have been concluded and
                          maintained to secure against risk arising in
                          connection with the business of L.A.B. and the
                          Subsidiaries until the Effective Date;

                 5.2.2    neither the execution, delivery and performance of
                          this Agreement by the Hofkammer nor the consummation
                          of the transactions contemplated hereby and thereby,
                          will

                          (i)     violate or conflict with, result in a breach
                                  of, or result in or permit the acceleration
                                  or termination of or constitute a default
                                  under (whether with notice or lapse of time
                                  or both) any agreement, instrument,
                                  indenture, mortgage, lien, lease or other
                                  contract to which L.A.B. or the Partner GmbH
                                  or a Subsidiary is a party or by which any of
                                  them or their property or assets is bound,
                                  provided such violation, conflict,
                                  acceleration, termination of default
                                  individually or in the aggregate would have a
                                  material adverse effect on their business;

                          (ii)    result in the creation of any lien, charge,
                                  or encumbrance on any of the property or
                                  assets of said companies which individually
                                  or in the aggregate would have an adverse
                                  effect on their business;

                 5.2.3    the financial statements contained in APPENDIX 5.2.3
                          fairly present the financial position and results of
                          operation of L.A.B. at the respective dates and for
                          the respective periods to which they apply;
<PAGE>   10
                                       10


                 5.2.4    APPENDIX 5.2.4 completely and correctly identifies
                          all contracts with licensors, contracts with
                          licensees, leases and other contracts relating to
                          L.A.B., the Partner GmbH or the Subsidiaries (other
                          (i) than contracts with employeees of L.A.B. listed
                          in APPENDIX 5.2.14 (a), including the service
                          agreements with Dr. Kappler and Mr. Feichter, (ii)
                          the two lease agreements with the Hofkammer referred
                          to in clause 4.1 of the Option Agreement, and (iii)
                          contracts with a monthly payment obligation of no
                          more than DM 10,000 and a term of less than one
                          year). Except as disclosed in such Appendix, neither
                          the Partner GmbH nor L.A.B. nor any Subsidiary is a
                          party or otherwise subject to

                          (i)     any contract, agreement or instrument
                                  evidencing or relating to any material amount
                                  of indebtedness for borrowed money or the
                                  deferred purchase price of property, or any
                                  direct or indirect guarantee of any such
                                  indebtedness or deferred purchase price, or

                          (ii)    any secrecy or other agreement or any
                                  injunction, judgment, order or award that (x)
                                  restricts the right of the Partner GmbH or
                                  L.A.B. or any Subsidiary to engage in any
                                  place in any line of business or (y) would
                                  restrict the right of the Partner GmbH or
                                  L.A.B. or any Subsidiary to engage in any
                                  place in any line of business after the
                                  Effective Date;

                 5.2.5    L.A.B. is the owner of the know-how incorporated in
                          the dossiers, listed in APPENDIX 5.2.5, all such
                          know-how is free and clear of any liens, pledges,
                          usufruct, and other encumbrances and L.A.B. can
                          freely dispose of such knowhow;
<PAGE>   11
                                       11


                 5.2.6    the Partner GmbH, L.A.B. and the Subsidiaries are
                          each in compliance in all material respects with all
                          laws, regulations, orders, judgments and decrees of
                          any court or governmental or administrative authority
                          applicable to their business so that there will be no
                          material detrimental impact for said companies in the
                          future;

                 5.2.7    either L.A.B. or the Partner GmbH, as the case may
                          be, owns, leases or has the legal right to use all
                          the properties and assets, including, without
                          limitation, the intellectual property and the real
                          property, used or intended to be used in the conduct
                          of its business or otherwise owned, leased or used by
                          said companies and, with respect to contract rights,
                          is a party to and enjoys the right to the benefits of
                          all contracts, agreements and other arrangements used
                          or intended to be used by said companies (all such
                          properties, assets and contract rights being the
                          "Assets"). Either L.A.B. or the Partner GmbH, as the
                          case may be, has good and marketable title to, or, in
                          the case of leased or subleased Assets, valid and
                          subsisting leasehold interests in, all the Assets,
                          free and clear of all encumbrances;

                          L.A.B. has caused the Assets to be maintained in
                          accordance with good business practice, and all
                          the Assets are in good operating condition and repair
                          and are suitable for the purposes for which they are
                          used and intended;

                 5.2.8    neither L.A.B. nor the Partner GmbH nor any
                          Subsidiary has entered into any agreement with the
                          Hofkammer, Dr. Jaeger and/or Ms. Jaeger or with any
                          company, trust or other entity controlled by the
                          aforesaid persons, with the exception of a
                          transaction with L.A.B. Canada in the amount of
                          approximately DM 1,000,000 in 1996, from which
                          transaction, however, there are no open claims;
 
<PAGE>   12
                                       12


                 5.2.9    neither L.A.B. nor the Partner GmbH nor any of its
                          Subsidiaries is a party to any contract in violation
                          of Section 1 of the Act Against Restraints on
                          Competition (Gesetz gegen Wettbewerbsbeschrankungen)
                          or respective foreign laws or requiring approval of
                          the Federal Cartel Office (Bundeskartellamt) or other
                          respective national authorities or the European
                          Commission without having duly filed a respective
                          application to receive such approval;

                 5.2.10   neither L.A.B. nor the Partner GmbH nor any of its
                          Subsidiaries has entered into any speculative
                          transactions including foreign exchange, options,
                          futures, or other derivative financial instruments;

                 5.2.11   other than normal salary there are no outstanding
                          amounts due to Mr. Feichter and Dr. Kappler except
                          for possible claims of Dr. Kappler for bonus payments
                          in the amount of approximately DM 220,000, for the
                          business years 1994, 1995, 1996, and for which an
                          accrual has been created in the interim balance sheet
                          of L.A.B.;

                 5.2.12   neither L.A.B. nor the Partner GmbH nor any of their

                          Subsidiaries is party to any proceeding pending or
                          threatened (including notification of customers for
                          malperformance) before any courts, government 
                          agencies or arbitration courts; said companies are
                          not subject to, in violation of or in default with
                          respect to any judgment, order writ or injunction and
                          such companies have no knowledge of to potentially
                          becoming subject to any official investigation, claim
                          or action which might be detrimental to the business
                          (e.g., conditions (Auflagen) to or revocation of
                          permits), all except the Apotex claims 
                          (US $ 188,306.80 and Can $ 40,000,000) and
                          any claims of the tax authorities;
<PAGE>   13
                                       13


                 5.2.13   L.A.B. has paid all social contributions, V.A.T. and
                          trade tax when due except for health insurance
                          payments for November 1996 (amounting to
                          approximately DM 650,000) and possible tax
                          liabilities referred to in clause 5.1.14 (ii);

                 5.2.14   Appendix 5.2.14 (a) contains a true and complete list
                          of all employees of L.A.B., the Partner GmbH and
                          their Subsidiaries; none of the key employees listed
                          in Appendix 5.2.14 (b) have communicated that they
                          intend to leave;

                 5.2.15   neither L.A.B. nor the Partner GmbH nor any of their
                          Subsidiaries has sold since January 1, 1996, any
                          assets outside the ordinary course of business; for
                          the avoidance of doubt: L.A.B. KK (Japan) has been
                          shut down for tax purposes and all assets (book value
                          DM 1 in the balance sheet 1994) have been transferred
                          to the Japanese tax authorities;

                 5.2.16   the Hofkammer has disclosed all facts and
                          circumstances which can reasonably be expected to be
                          material to NewCo.

         5.3     In case of a breach of any of the representations and
                 warranties under clause 5.1 and/or 5.2 the following applies:

                 5.3.1    In the event of an incorrect representation, the
                          Hofkammer is entitled to put NewCo in such position
                          as if the representation had been correct. If the
                          Hofkammer fails to cure the breach within a period of
                          three months after notification by NewCo, or if
                          immediate action is necessary (Gefahr im Verzug), the
                          Hofkammer shall refund to NewCo the damage in order
                          to establish the represented status. However, the
                          liability in case of a breach of a representation
                          shall be limited to DM 3,650,000, provided, that a
                          breach of the representation under clause 5.1.14
                          shall be limited to an amount of DM 1,575,000 with
                          prejudice to liabilities pursuant to the
<PAGE>   14
                                       14


                          other representations. It is understood that the
                          Hofkammer is entitled to offset any remedies owed
                          hereunder against any installments of the Purchase
                          Price not yet due for payment.

                 5.3.2    Claims of NewCo pursuant to this clause 5 shall
                          become time-barred 15 months after the Effective
                          Date, except for breach of warranties in connection
                          with clause 5.1.14, which remedies become time-barred
                          6 months after final tax assessments for L.A.B., the
                          Partner GmbH and their Subsidiaries have been
                          rendered after a tax audit with respect to the tax
                          periods until and including 1996. The limitation
                          period stops running if claims are asserted in
                          writing by NewCo against the Hofkammer and if the
                          reasons on which such claim is based are reasonably
                          identified. On request by the Hofkammer NewCo shall
                          lodge an appeal against tax assessments.  The Parties
                          shall mutually consent to the splitting of costs.


6.       COVENANTS

         6.1     Hofkammer agrees that neither it nor any of its associated
                 undertakings shall do business for a period of three years
                 after the Effective Date in the product or geographical
                 markets in which L.A.B. or any of its Subsidiaries operates at
                 the time of entry into this Agreement.

         6.2     Between the date of this notarial deed and the Effective Date
                 the Hofkammer shall instruct Mr. Feichter and Dr. Kappler not
                 to file for bankruptcy, provided, that the Hofkammer shall
                 have no liability if such bankruptcy will be filed.

         6.3     NewCo shall give the Hofkammer the opportunity to accompany
                 and have representatives at and participating in any tax
                 audits.
 
<PAGE>   15
                                       15


7.       MISCELLANEOUS

         7.1     Each Party shall bear its own costs and expenses in connection
                 with the negotiation, preparation and implementation of this
                 Agreement with the exception of notarial and court costs and
                 similar charges which shall be shared equally between the
                 Parties. Transfer taxes will be borne by NewCo.

         7.2     If any of the provisions contained in this Agreement are or
                 become invalid or impracticable for any reason, including by
                 virtue of the omission of any other provision, the validity of
                 the remaining provisions shall remain unaffected. The invalid
                 or impracticable provision shall be substituted or
                 supplemented by provisions that ensure the economic purpose of
                 the invalid or impracticable provision as far as possible.

         7.3     Unless otherwise specified in this Agreement, all notices and
                 other communications hereunder shall be in writing and in
                 English.

                          IF TO THE HOFKAMMER:
                                Hofkammer des Hauses Wurttemberg
                                - Direktion -
                                SchloB
                                88045 Friedrichshafen
                                Fax (+49-7541) 307-126

                          IF TO NEWCO:
                                Applied Analytical Industries Deutschland GmbH
                                c/o Shearman & Sterling
                                CouvenstraBe 8
                                40211 Dusseldorf
                                Fax (+49-211) 1 78 88-88
<PAGE>   16
                                       16


                          IF TO AAI:
                                Applied Analytical Industries, Inc.
                                attn. General Counsel
                                5051 New Centre Drive
                                Wilmington, NC 28403
                                U.S.A.
                                Fax: (+1-910) 392-6557

         7.4     All Annexes in this Agreement are considered a part hereof.

         7.5     Each of the Parties shall execute and deliver all such further
                 documents and agreements and do such further acts as are
                 reasonably required hereby and are not inconsistent with any
                 other provisions of this Agreement.

         7.6     The Parties agree to keep confidential all information
                 obtained in connection with this Agreement and its performance
                 as long as and to the extent that it has not been made known
                 to the public without fault of any of the Parties. If this
                 Agreement is terminated for any reason, this confidentiality
                 obligation shall remain in effect indefinitely.

         7.7     Neither this Agreement nor any right hereunder may be assigned
                 without the prior written consent of the other Parties unless
                 specifically stated otherwise. Any attempt to assign any right
                 hereunder without such approval will be void unless it is an
                 assignment or transfer by operation of law. Subject to the
                 preceding sentence, this Agreement is binding upon, inures to
                 the benefit of, and is enforceable by the Parties and their
                 respective successors and assignees.

         7.8     Each Party shall execute any further legal acts which are
                 required to achieve the goal of this agreement. This also
                 includes that the Hofkammer, upon request, will render all
                 necessary statements so that for the Buyer no undesirable
                 consequences will result from the exclusion of the Jaegers
                 agreed on by the shareholders' meeting.  This clause 7.8
                 contains no financial commitments for either Party.
<PAGE>   17
                                       17


         7.9     This Agreement shall be governed by the laws of the Federal
                 Republic of Germany. The exclusive place of jurisdiction is
                 Frankfurt am Main.


IN WITNESS THEREOF, this public deed and the Annexes have been read out in
their entirety in the presence of the appeared persons and in my presence.
After reading, this public deed and the Annexes have been found to be correct
and approved. After that the appeared persons have signed the public deed in my
presence, thereupon I, the notary public, have also signed this public deed and
affixed my official seal.


BALE, this 23rd (twenty-third) day of December 1996 (nineteen hundred and
ninety-six)


[Signatures and seal of notary public]


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