APPLIED ANALYTICAL INDUSTRIES INC
10-Q, 1998-05-15
MEDICAL LABORATORIES
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<PAGE>   1

                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 10-Q

[X]      QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934

                 For the quarterly period ended March 31, 1998

[ ]      TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934


                         Commission File Number 0-21185


                      APPLIED ANALYTICAL INDUSTRIES, INC.
             (Exact name of Registrant as specified in its charter)


          DELAWARE                                     04-2687849
(State or other jurisdiction of                     (I.R.S. employer
 incorporation or organization)                    identification no.)



               5051 NEW CENTRE DRIVE, WILMINGTON, NC     28403
              (Address of principal executive office)  (Zip code)


                                 (910) 392-1606
              (Registrant's telephone number, including area code)


Indicate by check mark whether the Registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. YES [X]  NO [ ]

The number of shares of the Registrant's common stock outstanding, as of May 11,
1998 was 16,302,542 shares.



<PAGE>   2


                       APPLIED ANALYTICAL INDUSTRIES, INC.
                                Table of Contents



The terms "Company", "Registrant" or "AAI" in this Form 10-Q include Applied
Analytical Industries, Inc. and its subsidiaries, except where the context may
indicate otherwise. Any item which is not applicable or to which the answer is
negative has been omitted.


                                                                        Page No.
                                                                        --------

PART I.  FINANCIAL INFORMATION

ITEM 1.  FINANCIAL STATEMENTS (unaudited)
         Condensed Consolidated Statement of Income                         2
         Condensed Consolidated Balance Sheet                               3
         Condensed Consolidated Statement of Cash Flows                     4
         Notes to Condensed Consolidated Financial Statements               5

ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
         CONDITION AND RESULTS OF OPERATIONS                                7

PART II. OTHER INFORMATION

ITEM 2.  CHANGES IN SECURITIES AND USE OF PROCEEDS                          9

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K                                   9


SIGNATURES                                                                 10


                                       1
<PAGE>   3


PART I. FINANCIAL INFORMATION

ITEM 1.   FINANCIAL STATEMENTS (unaudited)

                       APPLIED ANALYTICAL INDUSTRIES, INC.
                   Condensed Consolidated Statement of Income
                    (In thousands, except per share amounts)
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                Three months ended
                                                      March 31,
                                              -----------------------
                                                1998            1997
                                              -------         -------

<S>                                           <C>             <C>    
Net sales (includes related party net
   Sales of $407 and $1,975)                  $17,113         $15,175

Operating costs and expenses:
   Cost of sales                                8,497           7,491
   Selling                                      2,166           1,835
   General and administrative                   3,662           3,179
   Research and development                     1,403           1,618
                                              -------         -------
                                               15,728          14,123
                                              -------         -------

   Income from operations                       1,385           1,052

Other income (expense):
   Interest, net                                  132             327
   Other, net                                      11             124
                                              -------         -------
                                                  143             451
                                              -------         -------

Income before income taxes                      1,528           1,503
Provision for income taxes                        455             593
                                              -------         -------
Net income                                    $ 1,073         $   910
                                              =======         =======


Basic earnings per share                      $  0.07         $  0.06
                                              =======         =======
Weighted average shares outstanding            16,298          16,278

Diluted earnings per share                    $  0.07         $  0.06
                                              =======         =======
Weighted average shares outstanding            16,474          16,400
</TABLE>

   The accompanying notes are an integral part of these financial statements.


                                       2
<PAGE>   4

                       APPLIED ANALYTICAL INDUSTRIES, INC.
                      Condensed Consolidated Balance Sheet
                                 (In thousands)

<TABLE>
<CAPTION>
                                                                   March 31,        December 31,
                                                                     1998               1997
                                                                   --------          ---------
                                                                 (unaudited)
                                     ASSETS

<S>                                                               <C>               <C>      
Current assets:
Cash and cash equivalents                                          $ 26,123          $  26,219
Accounts receivable                                                  17,815             19,415
Work-in-progress                                                      9,819              8,968
Prepaid and other current assets                                      4,417              4,481
                                                                   --------          ---------
          Total current assets                                       58,174             59,083
                                                                   --------          ---------
Property and equipment, net                                          26,236             25,326
Goodwill and other intangibles                                       13,178             13,747
Other assets                                                          2,294              2,293
                                                                   --------          ---------
          Total assets                                             $ 99,882          $ 100,449
                                                                   ========          =========

                      LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities:
Current maturities of long-term debt
   and short-term debt                                             $  6,311          $   5,561
Accounts payable                                                      2,603              4,005
Customer advances                                                     7,918              7,869
Accrued wages and benefits                                            3,448              3,561
Other accrued liabilities                                             4,852              5,450
                                                                   --------          ---------
          Total current liabilities                                  25,132             26,446
                                                                   --------          ---------
Long-term debt                                                        6,268              6,578
Other liabilities                                                     1,108              1,349
Commitments and contingencies
Stockholders' equity:
  Preferred stock
  Common stock                                                           16                 16
  Paid-in capital                                                    67,706             67,550
  Accumulated deficit                                                  (263)            (1,336)
  Accumulated other comprehensive losses                                (19)                (5)
  Stock subscriptions receivable                                        (66)              (149)
                                                                   --------          ---------
          Total stockholders' equity                                 67,374             66,076
                                                                   --------          ---------
          Total liabilities and stockholders' equity               $ 99,882          $ 100,449
                                                                   ========          =========
</TABLE>


   The accompanying notes are an integral part of these financial statements.


                                       3
<PAGE>   5


                       APPLIED ANALYTICAL INDUSTRIES, INC.
                 Condensed Consolidated Statement of Cash Flows
                                 (In thousands)
                                   (Unaudited)

<TABLE>
<CAPTION>
                                                                Three months ended
                                                                     March 31,
                                                             --------------------------
                                                               1998              1997
                                                             --------          --------

<S>                                                          <C>               <C>     
Net income                                                   $  1,073          $    910
Adjustments to reconcile to net cash provided
    (used) by operating activities:
      Depreciation and amortization                             1,368             1,010

     Other                                                        384                75
     Changes in assets and liabilities:
         Trade and other receivables                            1,520              (810)
         Work-in-progress                                        (904)           (1,397)
         Prepaid and other assets, net                             46               (97)
         Accounts payable                                      (1,355)           (4,572)
         Customer advances                                        117                62
         Other accrued liabilities                               (858)           (2,200)
                                                             --------          --------
Net cash provided (used) by operating activities:               1,391            (7,019)
                                                             --------          --------
Cash flows from investing activities:
     Purchase of property and equipment                        (2,204)           (2,255)
     Other                                                        (32)             (165)
                                                             --------          --------
Net cash used by investing activities                          (2,236)           (2,420)
                                                             --------          --------
Cash flows from financing activities:
     Net proceeds short-term borrowings                           857             1,383
     Net proceeds (payments) long-term borrowings                (168)              732
     Sale of common stock                                          72                14
                                                             --------          --------
Net cash provided (used) by financing activities                  761             2,129
                                                             --------          --------
Net decrease in cash and cash equivalents                         (84)           (7,310)
Effect of exchange rate changes on cash                           (12)              (13)
Cash and cash equivalents, beginning of period                 26,219            42,186
                                                             --------          --------
Cash and cash equivalents, end of period                     $ 26,123          $ 34,863
                                                             ========          ========

Supplemental information, cash paid for:
     Interest                                                $    233          $    159
     Income taxes                                            $      0          $    317
</TABLE>

   The accompanying notes are an integral part of these financial statements.


                                       4
<PAGE>   6

                       APPLIED ANALYTICAL INDUSTRIES, INC.
              Notes to Condensed Consolidated Financial Statements
                                   (Unaudited)


1. BASIS OF PRESENTATION

The accompanying unaudited condensed consolidated financial statements have been
prepared in accordance with generally accepted accounting principles and
applicable Securities and Exchange Commission regulations for interim financial
information. These financial statements do not include all of the information
and footnotes required by generally accepted accounting principles for complete
financial statements. It is presumed that users of this interim financial
information have read or have access to the audited financial statements for the
preceding fiscal year. In the opinion of management, all adjustments (consisting
of normal recurring adjustments) considered necessary for fair presentation have
been included. Operating results for the interim periods presented are not
necessarily indicative of the results that may be expected for the full year.

2. EARNINGS PER SHARE

The weighted average shares used in the calculation of diluted earnings per
share represents the weighted average shares outstanding plus the dilutive
impact of stock options.

3. COMPREHENSIVE INCOME

The Company is required, effective fiscal year 1998, to report comprehensive
income and its components in accordance with the provisions of Statement of
Financial Accounting Standards No. 130, "Reporting Comprehensive Income."
Comprehensive income is defined as the change in equity during a period from
transactions and other events and circumstances from non-owner sources. The
following table presents the components of the Company's comprehensive income.


<TABLE>
<CAPTION>
                                            Three months ended
                                                 March 31,
                                           ----------------------
                                             (In thousands)
                                             1998          1997
                                           -------         ----

<S>                                        <C>             <C> 
Net income                                 $ 1,073          $910

Other comprehensive income (loss):
  Currency translation adjustments             (14)          --

                                           -------          ----
Comprehensive income                       $ 1,059          $910
                                           =======          ====

</TABLE>


                                       5
<PAGE>   7


4. FINANCIAL INFORMATION BY BUSINESS SEGMENT AND GEOGRAPHIC AREA

<TABLE>
<CAPTION>
                                           Three months ended
                                                March 31,
                                       --------------------------
                                             (In thousands)
                                         1998              1997
                                       --------          --------
<S>                                    <C>               <C>     
NET SALES:
Fee-for-service                        $ 15,577          $ 13,746
Internal product development              1,536             1,429
                                       --------          --------
                                       $ 17,113          $ 15,175
                                       ========          ========

United States                          $ 12,776          $ 11,682
Non-U.S.                                  4,786             3,739
Less inter-geographic sales                (449)             (246)
                                       --------          --------
                                       $ 17,113          $ 15,175
                                       ========          ========

INCOME (LOSS) FROM OPERATIONS:
Fee-for-service                        $  1,199          $  1,644
Internal product development                133              (189)
Corporate                                    53              (403)
                                       --------          --------
                                       $  1,385          $  1,052
                                       ========          ========

United States                          $  1,302          $  1,124
Non-U.S.                                     83               (72)
                                       --------          --------
                                       $  1,385          $  1,052
                                       ========          ========
</TABLE>


                                       6
<PAGE>   8

ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
        RESULTS OF OPERATIONS.

The Company's quarterly results have been, and are expected to continue to be,
subject to fluctuations. Quarterly results can fluctuate as a result of a number
of factors, including without limitation, the commencement, completion or
cancellation of large contracts, progress of ongoing contracts, achieving
expected levels of licensing and royalty revenues, potential acquisitions, the
timing of start-up expenses for new facilities and changes in the mix of
services. Since a large percentage of the Company's operating costs are
relatively fixed, variations in the timing and progress of large contracts or
the recognition of licensing and royalty revenues (on projects for which
associated expense may have been recognized in prior periods) can materially
affect quarterly results. Accordingly, the Company believes that comparisons of
its quarterly financial results may not be meaningful.

RESULTS OF OPERATIONS - FIRST QUARTER 1998 COMPARED TO FIRST QUARTER 1997

Net sales for the first quarter of 1998 increased 13% to $17.1 million compared
to $15.2 million in 1997. The core fee-for-service revenues were $15.6 million
in 1998, up 13% from $13.7 million in 1997. Revenues from licensing and
royalties were $1.5 million in 1998 compared to $1.4 million last year.
Although the 1998 internal product development revenues were comparable to
1997, the Company did not finalize any new domestic license agreements.

Overall gross margin, of 50%, was approximately the same for both the first
quarter of 1998 and 1997, but was up slightly from the fourth quarter 1997 gross
margin of 49%. The gross margin from fee-for-service work was approximately 46%
for both the first quarter of 1998 and 1997 which was also slightly better than
the fourth quarter 1997 level of 43%.

Selling expense as a percentage of net sales increased to 13% compared to 12.0%
last year. The increase primarily resulted from the additions to the European
marketing activities implemented during 1997. General and administrative
expenses as a percentage of net sales were approximately even, at 21% in both
1998 and 1997. The 1998 general and administrative expenses include a gain of
approximately $540,000 resulting from the sale of certain corporate assets. The
Company expects to continue its efforts at controlling general and
administrative expenses in line with overall growth.

Research and development expenses were $1.4 million in 1998 compared to $1.6
million in 1997. The Company has continued spending on internal development
projects. The lower 1998 spending reflects the cost efficiency of using internal
facilities rather than outside third parties for certain clinical work.


LIQUIDITY AND CAPITAL RESOURCES

The Company has historically funded its business through operating cash flows,
proceeds from borrowings and the issuance of equity securities. Working capital
was approximately $33.0 million at March 31, 1998 compared to approximately
$32.6 million at December 31, 1997. Additionally, the Company has available a
$20 million credit facility to supplement its liquidity needs.

                                       7
<PAGE>   9

Capital expenditures were approximately $2.2 million during the first quarter of
1998 compared to approximately $2.3 million during the same period last year.
The Company anticipates total capital expenditures for 1998 to be at or below
1997 levels.

AAI expects to continue expanding its operations through internal growth and
strategic acquisitions. The Company expects such activities will be funded from
existing cash and cash equivalents, cash flow from operations and borrowings.
The Company believes that such sources of cash will be sufficient to fund
operations for the current and foreseeable future and to pay existing debt as it
becomes due and other capital obligations. The Company is constantly evaluating
acquisition or growth opportunities. At some point in the future there may be
opportunities that require additional external financing, and the Company may
from time-to-time seek to obtain funds through the public or private issuance of
equity or debt securities. There can be no assurances that such financing will
be available on terms acceptable to the Company.

YEAR 2000 DISCLOSURE

The Company is in the process of completing its assessment of the impact to
computer systems and equipment when the year 2000 arrives. Over the past few
years a number of computer systems that were not year 2000 compatible have
either been upgraded or replaced. While management does not believe this issue
will materially affect its products, services or competitive condition, it has
not fully completed its assessment at this time.

FORWARD LOOKING STATEMENTS

This quarterly report may contain certain forward-looking statements, within the
meaning of Section 27A of the Securities Act of 1933, as amended, and Section
21E of the Securities Exchange Act of 1934, as amended, that are based on the
Company's belief and assumptions, as well as information currently available to
the Company. When or if used herein, the words "anticipate," "estimate,"
"expect," and similar expressions may identify forward-looking statements.
Although the Company believes that the expectations reflected in any such
forward-looking statements are reasonable, there can be no assurance that such
expectations will prove to be correct. Any such statements are subject to
certain risks and uncertainties. Should one or more of these risks or
uncertainties materialize, or should underlying assumptions prove incorrect,
actual results, performance or financial condition may vary materially from
those anticipated, estimated or expected. Key factors that may have a direct
bearing on the Company's results, performance and financial condition include,
but are not limited to, the Company's dependence on and effect of government
regulation; its management of growth and acquisition risks, including its
integration of acquired operations; the level of outsourcing of research,
development and testing activities in the pharmaceutical and biotechnology
industries; its dependence on key personnel, and its dependence on third-party
marketing and distribution of internally developed drugs.


                                       8
<PAGE>   10

PART II. OTHER INFORMATION

ITEM 2.  CHANGES IN SECURITIES AND USE OF PROCEEDS

USE OF PROCEEDS.

In 1996, the Company completed the sale of 3,105,000 shares of common stock
through an offering filed on Registration Statement Form S-1 (No. 333-5535)
which became effective on September 19, 1996. The net offering proceeds to the
Company after underwriting discounts and other expenses, as previously disclosed
in other Company filings, was $44,793,000. A reasonable estimate for the
application of such proceeds is described below. Such information represents
cumulative totals through the reporting date of this periodic report and all
amounts, unless indicated otherwise, are for direct or indirect payments to
others.

<TABLE>
<S>                                                          <C>        
Construction of plant, building and facilities               $ 4,980,000
Purchase and installation of machinery and equipment          10,805,000
Repayment of indebtedness                                      1,471,000
Working capital                                                6,654,000
Research and development                                      10,448,000
Temporary investments (short-term, investment grade,
 Interest-bearing)                                            10,435,000
                                                             -----------
          Use of proceeds                                    $44,793,000
                                                             ===========
</TABLE>


ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K.

EXHIBITS:

A list of the exhibits required to be filed as part of this Report on Form 10-Q
is set forth in the "Exhibit Index", which immediately precedes such exhibits,
and is incorporated herein by reference.

REPORTS ON FORM 8-K:

No reports on Form 8-K were filed during the quarter ended March 31, 1998;
however, the Company did file a report on Form 8-K, dated April 30, 1998, to
report the change in independent accountants.


                                       9
<PAGE>   11

                                   SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange
Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized.

                             APPLIED ANALYTICAL INDUSTRIES, INC.

Date:  May 15, 1998          By:  /s/   FREDERICK D. SANCILIO
                                 ---------------------------------
                                 Frederick D. Sancilio, Ph.D.
                                 Chairman of the Board and Chief Executive
                                 Officer (Principal Executive Officer)

Date:  May 15, 1998          By:  /s/  EUGENE T. HALEY
                                 ---------------------------------
                                 Eugene T. Haley
                                 Executive Vice President and 
                                 Chief Financial Officer
                                 (Principal Financial Officer)



                                       10
<PAGE>   12

                       APPLIED ANALYTICAL INDUSTRIES, INC.
                                  EXHIBIT INDEX

EXHIBIT
   NO.                             DESCRIPTION
   ---                             -----------

 3.1    -Amended and Restated Certificate of Incorporation of the Company
         (incorporated by reference to Exhibit 3.1 to the Company's Quarterly
         Report on Form 10-Q for the quarter ended September 30, 1996)

 3.2    -Restated By-laws of the Company (incorporated by reference to Exhibit
         3.2 to the Company's Registration Statement on Form S-1 (Registration
         No. 333-5535))

 4.1    -Articles Fourth, Seventh, Eleventh and Twelfth of the form of Amended
         and Restated Certificate of Incorporation of the Company (included in
         Exhibit 3.1)

 4.2    -Article II of the form of Restated By-laws of the Company (included in
         Exhibit 3.2)

 4.3    -Specimen Certificate for shares of Common Stock, $.001 par value, of
         the Company (incorporated by reference to Exhibit 4.3 to the Company's
         Registration Statement on Form S-1 (Registration No. 333-5535))

10.1    -Employment Agreement dated November 17, 1995 between the Company and
         Frederick D. Sancilio (incorporated by reference to Exhibit 10.1 to the
         Company's Registration Statement on Form S-1 (Registration No.
         333-5535))

10.2    -Applied Analytical Industries, Inc. 1995 Stock Option Plan
         (incorporated by reference to Exhibit 10.3 to the Company's
         Registration Statement on Form S-1 (Registration No. 333-5535))

10.3    -Applied Analytical Industries, Inc. 1996 Stock Option Plan
         (incorporated by reference to Exhibit 10.4 to the Company's
         Registration Statement on Form S-1 (Registration No. 333-5535))


10.4    -Applied Analytical Industries, Inc. 1997 Stock Option Plan
         (incorporated by reference to Exhibit 10.5 to the Company's Quarterly
         Report on Form 10-Q for the quarter ended September 30, 1997)

10.5    -Stockholder Agreement dated as of November 17, 1995 among the
         Company, GS Capital Partners II, L.P., GS Capital Partners II Offshore,
         L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street Fund 1995,
         L.P., Bridge Street Fund 1995, L.P., Noro-Moseley Partners III, L.P.,
         Wakefield Group Limited Partnership, James L. Waters, Frederick D.
         Sancilio and the parties listed on Schedule 1 thereto (incorporated by
         reference to Exhibit 10.5 to the Company's Registration Statement on
         Form S-1 (Registration No. 333-5535))

10.6    -Lease Agreement dated as of March 7, 1994 between 5051 New Centre
         Drive, L.L.C., as landlord, and the Company, as tenant (incorporated by
         reference to Exhibit 10.10 to the Company's Registration Statement on
         Form S-1 (Registration No. 333-5535))

                                       11
<PAGE>   13

10.7    -Development Agreement dated as of April 25, 1994 between the Company
         and Endeavor Pharmaceuticals Inc. (formerly, GenerEst, Inc.)
         (incorporated by reference to Exhibit 10.12 to the Company's
         Registration Statement on Form S-1 (Registration No. 333-5535))


10.8    -Development Agreement dated as of April 4, 1995 between the Company
         and Aesgen, Inc. (incorporated by reference to Exhibit 10.13 to the
         Company's Registration Statement on Form S-1 (Registration No. 333-
         5535))

10.9    -Loan Agreement dated as of December 30, 1996 between NationsBank, N.A.
         and the Company (incorporated by reference to Exhibit 10.14 to the
         Company's Annual Report on Form 10-K for the year ended December 31,
         1996)

10.10   -Amendment No. 1, dated as of February 13, 1998, to the Loan Agreement
         dated as of December 30, 1996 between NationsBank, N.A. and the Company

10.11   -Underwriting Agreement dated September 19, 1996 between the Company
         and Goldman Sachs & Co., Cowen & Company and Lehman Brothers, Inc., as
         representatives of the underwriters listed on Schedule 1 thereto
         (incorporated by reference to Exhibit 10.17 to the Company's Quarterly
         Report on Form 10-Q for the quarter ended September 30, 1996)

27       Financial Data Schedule (for SEC use only)



                                       12

<PAGE>   1


                                                                   EXHIBIT 10.10


                        FIRST AMENDMENT TO LOAN AGREEMENT

         THIS FIRST AMENDMENT TO LOAN AGREEMENT, dated as of February 13, 1998
(the "First Amendment") is by and between

         APPLIED ANALYTICAL INDUSTRIES, INC., a corporation organized and
existing under the laws of the State of Delaware and having its principal place
of business in Wilmington, North Carolina (the "Borrower"); and

         NATIONSBANK, N.A., a national banking association organized and
existing under the laws of the United States and having offices in Wilmington,
North Carolina (the "Bank").

RECITALS

         A. The Bank and the Borrower have entered into that certain Loan
Agreement, dated as of December 30, 1996 (the "Loan Agreement").

         B. The Bank and the Borrower have agreed to make changes to the Loan
Agreement as provided for herein.

         NOW, THEREFORE, the parties hereto agree as follows:

         1. The Loan Agreement is hereby amended as follows:

         (a) Section 1.01 is amended by deleting the references to "Adjusted CD
Rate" and "CD Rate" contained therein;

         (b) Section 1.01 is further amended by amending in their entirety the
definitions of "Adjusted LIBOR Rate", "Applicable Percentage", "EBITDA", "Funded
Debt" and "Revolving Loan Maturity Date" so that such definitions now read as
follows:

         "Adjusted LIBOR Rate" means the rate as determined by the Bank at which
deposits in the requested amount and for one month interest periods are offered
to prime banks in the London Interbank Market, as published weekly by the
Federal Reserve Bank of New York in its H-15 Statistical Release, such rate
being adjusted for the cost of reserve requirements as prescribed by the Federal
Reserve System. The Adjusted LIBOR rate for any Saturday or Sunday or any other
day on which the London Interbank Market is not open shall be the Adjusted LIBOR
rate for the immediately preceding day on which the London Interbank Market is
open.

         "Applicable Percentage" means for the Revolving Loans, the appropriate
applicable percentages corresponding to the ratio of Funded Debt to EBITDA in
effect as of the most recent Calculation Date as shown below (with such ratio to
be computed for the four consecutive quarterly periods ending as of the
applicable Calculation Date):



<PAGE>   2


             Tier              Ratio of Funded Debt          LIBOR Margin
                               to EBITDA
             -------------------------------------------------------------------
             One               equal to or                       0.50%
                               less than 1.0
                               to 1.0

             Two               greater than                      0.75%
                               1.0 to 1.0
                               but equal
                               to or less
                               than 2.0 to 1.0

             Three             greater than                      1.00%
                               2.0 to 1.0

         The Applicable Percentage for Revolving Loans shall, in each case, be
determined and adjusted quarterly on each March 1, June 1, September 1 and
December 1 (each a "Calculation Date"); provided that the initial Applicable
Percentage shall be based on Tier Three and shall remain at Tier Three until the
Calculation Date on March 1, 1998, and, thereafter, the Applicable Percentage
shall be determined by the then current Leverage Ratio. Each Applicable
Percentage shall be effective from one Calculation Date until the next
Calculation Date.

         "EBITDA" means for any period of computation, earnings before interest
expense, provision for income taxes, depreciation, amortization, other non-cash
charges and lease expense under the tax retention operating lease (or similar
agreement) entered into with the Bank or any of its affiliates;

         "Funded Debt" means (i) all interest bearing obligations of the
Borrower including, without limitation, all obligations evidenced by promissory
notes or other similar contracts but excluding such items as trade payables and
accruals and (ii) all outstanding obligations under the tax retention operating
lease (or similar agreement) entered into with the Bank or any of its
affiliates.

         "Revolving Loan Maturity Date" means May 31, 1999.

         (c) Section 2.01 is amended in its entirety so that such Section now
reads as follows:



<PAGE>   3


         2.01 Revolving Loans. Subject to the terms and conditions and relying
upon the representations and warranties herein set forth, the Bank agrees to
make Revolving Loans to the Borrower, at any time or from time to time on or
after the date hereof and until the Revolving Loan Maturity Date, in an
aggregate principal amount at any time outstanding not to exceed TWENTY MILLION
DOLLARS ($20,000,000.00) (the "Revolving Loan Committed Amount") for purposes of
financing the Borrower's capital expenditures, acquisitions and working capital
needs. The Borrower may borrow, repay and reborrow hereunder on or after the
date hereof and prior to the Revolving Loan Maturity Date, subject to the terms,
provisions and limitations set forth herein. The outstanding principal balance
of the Revolving Loans on the Revolving Loan Maturity Date (the "Outstanding
Balance") shall be paid in 60 consecutive installments, the first 59 of which
shall be in an amount equal to 1/60th of the Outstanding Balance and the 60th of
which shall be in an amount equal to the then remaining portion of the
Outstanding Balance. Such principal installments shall commence on June 30, 1999
and shall continue thereafter through and including the final principal
installment due on May 31, 2004.

         (d) Section 2.03 is amended in its entirety so that such Section now
reads as follows:

         2.03 Interest. The outstanding principal balance of the Revolving Loans
shall bear interest at a rate equal to the Adjusted LIBOR Rate plus the
Applicable Margin. Interest calculated at the foregoing rates shall be due and
payable monthly in arrears on the last day of each month.

         (e) Sections 6.01(p)(ii) and (iv) are deleted in their entirety.

         C. The Borrower hereby represents and warrants that:

         1. the "Representations and Warranties" set forth in Article V of the
Loan Agreement, as amended, are true and correct as of the date of this First
Amendment except for the information included in the attached revised Exhibits
5.05, 5.08(a) and 5.10;

         2. no Event of Default exists under the Loan Agreement or the other
Loan Documents (as defined in the Loan Agreement) and no event or condition
exists under the Loan Agreement or the other Loan Documents that, but for the
giving of notice or lapse of time or both, would result in such and Event of
Default as of the date of this First Amendment.

         D. Except as modified hereby, all of the terms and provisions of the
Loan Agreement (and Exhibits) remain in full force and effect.

         E. This First Amendment may be executed in any number of counterparts,
each of which when so executed and delivered shall be deemed an original.

         F. This First Amendment and the Loan Agreement, as amended hereby,
shall be deemed to be contracts made under, and for all purposes shall be
construed in accordance with, the laws of the State of North Carolina.


<PAGE>   4


         IN WITNESS WHEREOF, the parties hereto have caused this First Amendment
to be executed by their duly authorized corporate officers as of the day and
year first above written.

                                     APPLIED ANALYTICAL INDUSTRIES, INC.

ATTEST:

By: /s/ Albert N. Cavagnaro           By:   /s/ Stephen F. Rizzo

Title:  Assistant Secretary           Title: Vice President




      (Corporate Seal)

                                      By: /s/ Charles A. Deignan

                                      Title: Assistant Treasurer


                                      NATIONSBANK, N.A.

                                      By: /s/ David C. Houston

                                      Title: Vice President



<TABLE> <S> <C>

<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
FINANCIAL STATEMENTS OF APPLIED ANALYTICAL INDUSTRIES, INC. AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-START>                             JAN-01-1998
<PERIOD-END>                               MAR-31-1998
<CASH>                                          26,123
<SECURITIES>                                         0
<RECEIVABLES>                                   17,999
<ALLOWANCES>                                       184
<INVENTORY>                                          0
<CURRENT-ASSETS>                                58,174
<PP&E>                                          42,307
<DEPRECIATION>                                  16,307
<TOTAL-ASSETS>                                  99,882
<CURRENT-LIABILITIES>                           25,132
<BONDS>                                              0
                                0
                                          0
<COMMON>                                            16
<OTHER-SE>                                      67,358
<TOTAL-LIABILITY-AND-EQUITY>                    99,882
<SALES>                                         17,113
<TOTAL-REVENUES>                                17,113
<CGS>                                            8,497
<TOTAL-COSTS>                                    8,497
<OTHER-EXPENSES>                                 7,231
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 233
<INCOME-PRETAX>                                  1,528
<INCOME-TAX>                                       455
<INCOME-CONTINUING>                                  0
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                     1,073
<EPS-PRIMARY>                                     0.07
<EPS-DILUTED>                                     0.07
        

</TABLE>


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