MAXIM PHARMACEUTICALS INC
4, 1998-08-04
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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FORM 4

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                     FORM 4

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
       Section 17(a) of the Public Utility Holding Company Act of 1935 or
               Section 30(f) of the Investment Company Act of 1940

|_| Check this box if no longer subject to Section 16. Form 4 or Form 5
    obligations may continue. See Instruction 1(b).

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1. Name and Address of Reporting Person

     Clearwater Offshore Fund Ltd.
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   (Last)               (First)                 (Middle)

     c/o New World Trustees (Bahamas) Ltd.,
     Euro-Canadian Centre, Marlboro Street
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                                    (Street)

     P.O. Box N-4465, Nassau, Bahamas
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   (City)               (State)                 (Zip)


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2. Issuer Name and Ticker or Trading Symbol

     Maxim Pharmaceuticals, Inc. - MAXM
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3. IRS or Social Security Number of Reporting Person (Voluntary)

     
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4. Statement for Month/Year

     December 1997
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5. If Amendment, Date of Original (Month/Year)

   
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6. Relationship of Reporting Person to Issuer
   (Check all applicable)

   |_|   Director                             |_|   10%
   |_|   Officer (give title below)           |X|   Other (specify below)(1)

(1)  Member of 13(d) group owning more than 10%
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7. Individual or Joint/Group Filing (Check Applicable Line)
   |_|  Form filed by One Reporting Person
   |_|  Form filed by More than One Reporting Person

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<PAGE>

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           Table I -- Non-Derivative Securities Acquired, Disposed of,
                             or Beneficially Owned
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<TABLE>
<CAPTION>
                                                                                                                6.
                                                                 4.                              5.             Owner-
                                                                 Securities Acquired (A) or      Amount of      ship
                                                    3.           Disposed of (D)                 Securities     Form:     7.
                                                    Transaction  (Instr. 3, 4 and 5)             Beneficially   Direct    Nature of
                                      2.            Code         ------------------------------- Owned at End   (D) or    Indirect
1.                                    Transaction   (Instr. 8)                   (A)             of Month       Indirect  Beneficial
Title of Security                     Date          ------------     Amount      or     Price    (Instr. 3      (I)       Ownership
(Instr. 3)                            (mm/dd/yy)     Code     V                  (D)             and 4)         (Instr.4) (Instr. 4)
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<S>                                   <C>            <C>      <C>    <C>         <C>    <C>       <C>           <C>       <C>
Common Stock                          10/30/97       P4              6,824        A     $14.1096                 D
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Common Stock                          10/31/97       P4             10,500        A     $15.0905                 D
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Common Stock                          11/26/97       P4              8,000        A     $15.0281                 D
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Common Stock                          11/28/97       P4             23,600        A     $15.3093                 D
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Common Stock                          12/29/97       P4              1,000        A     $15.375                  D
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Common Stock                          12/31/97       P4              3,200        A     $16.3736  200,183        D
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====================================================================================================================================
</TABLE>

(1) Clearwater Offshore Fund, Ltd. ("Clearwater Offshore") and Clearwater Fund
IV, LLC ("Clearwater LLC"), constitute a "group" owning more than 10% of the
Common Stock of the Issuer for purposes of Section 13(d) of the Securities
Exchange Act of 1934, as amended, by virtue of the fact that Hans Frederic Heye,
the Managing Member of Clearwater LLC is the President of Clearwater Futures,
Inc., the trading manager of Clearwater Offshore.

Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly.

<PAGE>


FORM 4 (continued)

Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned
            (e.g., puts, calls, warrants, options, convertible securities)

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<TABLE>
<CAPTION>
                                                                                                          9.        10.    
                                                                                                          Number    Owner- 
                                                                                                          of        ship   
                    2.                                                                                    Deriv-    of     
                    Conver-                    5.                              7.                         ative     Deriv-   11.    
                    sion                       Number of                       Title and Amount           Secur-    ative    Nature 
                    of                         Derivative    6.                of Underlying     8.       ities     Secur-   of     
                    Exer-             4.       Securities    Date              Securities        Price    Bene-     ity:     In-    
                    cise     3.       Trans-   Acquired (A)  Exercisable and   (Instr. 3 and 4)  of       ficially  Direct   direct 
                    Price    Trans-   action   or Disposed   Expiration Date   ----------------  Deriv-   Owned     (D) or   Bene-  
1.                  of       action   Code     of(D)         (Month/Day/Year)            Amount  ative    at End    In-      ficial 
Title of            Deriv-   Date     (Instr.  (Instr. 3,    ----------------            or      Secur-   of        direct   Owner- 
Derivative          ative    (Month/  8)       4 and 5)      Date     Expira-            Number  ity      Month     (I)      ship   
Security            Secur-   Day/     ------   ------------  Exer-    tion               of      (Instr.  (Instr.   (Instr.  (Instr.
(Instr. 3)          ity      Year)    Code V    (A)   (D)    cisable  Date     Title     Shares  5)       4)        4)       4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>      <C>      <C>  <C>  <C>   <C>    <C>      <C>      <C>       <C>     <C>      <C>       <C>      <C>


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====================================================================================================================================
</TABLE>

Explanation of Responses:

CLEARWATER OFFSHORE FUND LTD.
By: MANNING CONSULTANTS LTD., a Director
By: FALKIRK S.A., as Attorney-in-Fact


/s/ Carol Goodwin
- ---------------------------
Name: Carol Goodwin                                              6/29/98
Title: Director                                          -----------------------
                                                                  Date

**    Signature of Reporting Person

**    Intentional misstatements or omissions of facts constitute Federal
      Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If
      space provided is insufficient, see Instruction 6 for procedures.




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